22-11-2012 дата публикации
Номер: US20120296081A1
Автор:
William R. Blakemore,
Arthur D. Ballard,
Christopher J. Sewall,
James J. Modliszewski,
William A. Bubnis,
BLAKEMORE WILLIAM R,
BALLARD ARTHUR D,
SEWALL CHRISTOPHER J,
MODLISZEWSKI JAMES J,
BUBNIS WILLIAM A,
BLAKEMORE WILLIAM R.,
BALLARD ARTHUR D.,
SEWALL CHRISTOPHER J.,
MODLISZEWSKI JAMES J.,
BUBNIS WILLIAM A.
Принадлежит:
Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more carrageenans, including lambda carrageenan. Also disclosed are methods for making and using the compositions. 1. A process for making a metal carrageenate comprising precipitating carrageenan comprising a lambda carrageenan in alcohol , soaking said precipitated carrageenan in a solution containing a metal salt , alcohol and water , separating the metal carrageenate from the solution , washing and drying.2. The process of claim 1 , wherein the metal is zinc.3. The process of claim 2 , wherein said solution contains 50:50 alcohol:water and 2.5% zinc salt.4. The process of claim 2 , wherein said soaking step is repeated at least once. This application is a continuation of International Application No. PCT/US03/13456, filed on Apr. 30, 2003, which claims the benefit of the filing date of U.S. Provisional Patent Application No. 60/376,400, filed on Apr. 30, 2002, and U.S. Provisional Patent Application No. 60/377,050, filed on May , 2002, the disclosures of which are incorporated herein by reference.Carrageenans are polysaccharides obtained from the red algae commonly known as seaweed. They are a structural component of seaweed and are extracted as three main types, namely iota, kappa and lambda, although there are other types as well, including kappa-II, mu and nu carrageenans. Carrageenans have been used extensively in the food, pharmaceutical and cosmetics industries as thickeners, gelling agent, and stabilizing and dispersing agents. Extensive pharmacological and toxicological studies have been conducted. Carrageenan has been found to be non-toxic by oral, dermal, and inhalation routes of administrations even at extremely high doses. The carrageenans were therefore classified as “generally recognized as safe” (GRAS) by the FDA in 1972. Further extensive oral pharmacokinetic studies conducted in pigs, rats, mice, gerbils, guinea pigs, ferrets, hamsters, ...
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