Billing system for communications services involving telephony and instant communications

Systems, methods and program products are disclosed for determining billable usage of a communications system where services are provided involving telephony and instant communications. In some exemplary embodiments, the present invention provides for authorizing the fulfillment of service requests based upon information pertaining to a billable account.

Adamantyl derivatives as therapeutic agents

The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis.

Universal communications identifier

An approach is provided for supporting a plurality of communication modes through universal identification. A core identifier is generated for uniquely identifying a user among a plurality of users within the communication system. One or more specific identifiers are derived based upon the core identifier, wherein the specific identifiers serve as addressing information to the respective communication modes. The specific identifiers and the core identifier are designated as a suite of identifiers allocated to the user.

Method and system for providing remote digital media ingest with centralized editorial control

An approach provides for remote digital media ingest with centralized editorial. A remote ingest process is initiated over a data network to create a media file from a feed (such as a live broadcast feed). The media file is stored at a central repository. A device is configured to edit the media file by using a proxy file of the media file, wherein the proxy file represents a reduced file size of the media file.

Method and system for call disposition messaging

A method and system for creating and sending call disposition messages. When a calling card call is validated by the telephone network which issued the card, the card issuing network can request a call disposition message. In response to validation of the call, a billing detail record is generated and stored. When the call is completed. an operator service record is generated. The operator service record and its corresponding billing detail record are matched with each other, then merged to form a merged operator services record. The merged operator services record is processed to add pricing information. If the card issuing network had requested a call disposition message, the merged operator services record is sent to a gateway coupled to the card issuing network where it is reformatted to create a call disposition message. The call disposition message is then sent to the card issuing network.

METHOD AND SYSTEM FOR PROVIDING A PERSONAL VIDEO RECORDER UTILIZING NETWORK-BASED DIGITAL MEDIA CONTENT

An approach provides for recording and editing digital media. A digital media stream is generated from an input signal (such as a live broadcast feed). The digital media stream is transmitted to a browser application configured to concurrently record and edit the digital media stream.

Digital media asset management system and method for supporting multiple users

An approach provides editing of digital media. A platform, as maintained by a service provider, provides a remote proxy editing capability of a plurality of media streams. A first one of the media streams is transmitted to a player of a first customer of the service provider. Further, the method comprises transmitting a second one of the media streams to a player of a second customer of the service provider.

METHOD FOR CHARGING ON-LINE DIRECTORY ASSISTANCE SERVICES

An approach for providing an on-line directory assistance service system for charging the directory assistance services that are provided over a packet switched network is disclosed. The system includes a server that tracks the number of directory listings that are transmitted to and displayed on a client access device (e.g., non-PC devices) and to prepare billing information based upon the number of directory listings. The system also includes a database that is coupled to the server and that stores the directory listings.

Method and system for dynamic control of digital media content playback and advertisement delivery

An approach provides control of digital media. A stream of digital media that includes an advertisement is received. The stream is selectively skipped to avoid the advertisement. In addition, the amount of advertisement played back is tracked. Further, tracking information is generated based on the tracking.

Method and system for providing a personal video recorder utilizing network-based digital media content

An approach provides for recording and editing digital media. A digital media stream is generated from an input signal (such as a live broadcast feed). The digital media stream is transmitted to a browser application configured to concurrently record and edit the digital media stream.

Communication converter for converting audio information/textual information to corresponding textual information/audio information

A communication converter is described for converting among speech signals and textual information, permitting communication between telephone users and textual instant communications users.

Provision of telephony caller ID service via common instant communications clients

An approach is provided for supporting telephony services over a data network. A communication network establishes a voice session from a calling station to a called station associated with a user. A service platform, in communication with the communication network, obtains Caller ID information corresponding to the voice session, and determines an instant communication client of the user. The Caller ID information is transmitted over the data network to the instant communication client for display of the Caller ID information.

Method and system for delivery of digital media experience via common instant communication clients

An approach provides delivery of digital media. One of a plurality of distribution channels is assigned to transport the digital media to an instant communications process. The digital media is transmitted to the instant communications process over the assigned distribution channel.

Provision of voice mail messaging indicator and voice mail access services via common instant communications clients

An approach is provided for supporting telephony services over a data network. The approach aggregate message waiting indication information from one or more voice mail systems for notifying a user of the presence of a voice mail message resident on any one of the voice mail systems. According to a user profile, a notification message is transmitted over the data network to one or more instant communication clients based upon the aggregated message waiting indication information, wherein the notification message specifies the presence of the voice mail message.

Method and system for providing a personal video recorder utilizing network-based digital media content

An approach provides for recording and editing digital media. A digital media stream is generated from an input signal (such as a live broadcast feed). The digital media stream is transmitted to a browser application configured to concurrently record and edit the digital media stream.

Method and system for providing remote digital media ingest with centralized editorial control

An approach provides for remote digital media ingest with centralized editorial. A remote ingest process is initiated over a data network to create a media file from a feed (such as a live broadcast feed). The media file is stored at a central repository. A device is configured to edit the media file by using a proxy file of the media file, wherein the proxy file represents a reduced file size of the media file.

Method and system for dynamic control of digital media content playback and advertisement delivery

An approach provides control of digital media. A stream of digital media that includes an advertisement is received. The stream is selectively skipped to avoid the advertisement. In addition, the amount of advertisement played back is tracked. Further, tracking information is generated based on the tracking.

Method and system for providing universal relay services

An approach for providing instant messaging (IM) services is disclosed. A request is received from a source client to establish communication with a destination client associated with a subscriber over a first IM environment, wherein the request specifies a first user name derived from a unique identifier of the subscriber. A unique identifier is determined from the first user name. Further, a profile of the subscriber is accessed based on the unique identifier to determine a second user name corresponding to a second IM environment. An IM session is established between the source client and the destination client over the first and second IM environments using the respective first user name and second user name.

Method and system for providing a personal video recorder utilizing network-based digital media content

An approach provides for recording and editing digital media. A digital media stream is generated from an input signal (such as a live broadcast feed). The digital media stream is transmitted to a browser application configured to concurrently record and edit the digital media stream.

Messaging response system providing translation and conversion written language into different spoken language

A messaging response system is disclosed wherein a service providing system provides services to users via messaging communications. In accordance with an exemplary embodiment of the present invention, multiple respondents servicing users through messaging communications may appear to simultaneously use a common screen name identifier.

Provision of telephony caller ID service via common instant communications clients

An approach is provided for supporting telephony services over a data network. A communication network establishes a voice session from a calling station to a called station associated with a user. A service platform, in communication with the communication network, obtains Caller ID information corresponding to the voice session, and determines an instant communication client of the user. The Caller ID information is transmitted over the data network to the instant communication client for display of the Caller ID information.

Comprehensive communication services system

An approach is provided for offering communication services supported by a data network and a telephony network. A primary identifier is assigned to a user for access to the communication services, wherein the primary identifier is used by a party seeking to communicate with the user via one of the communication services. The primary identifier is mapped to one of a plurality of secondary identifiers corresponding to the respective communication services. The one secondary identifier is used by at least one of the data network and the telephony network to establish a communication session between the party and the user.

DIGITAL MEDIA ASSET MANAGEMENT SYSTEM AND METHOD FOR SUPPORTING MULTIPLE USERS

An approach provides editing of digital media. A platform, as maintained by a service provider, provides a remote proxy editing capability of a plurality of media streams. A first one of the media streams is transmitted to a player of a first customer of the service provider. Further, the method comprises transmitting a second one of the media streams to a player of a second customer of the service provider.

Method and system for providing distributed editing and storage of digital media over a network

An approach provides distributed editing and storage of digital media. Video information is retrieved during recording of the video information to a video file. The video information is edited during the recording of the video information. An index file for the media is generated during the recording of the media, wherein the index file include indices for decoding the media; and periodically updating the index file throughout the recording of the media. After completion of the recording of the media, another index file is generated corresponding to the media for inclusion into the media file.

PROVISION OF TELEPHONY CALLER ID SERVICE VIA COMMON INSTANT COMMUNICATIONS CLIENTS

An approach is provided for supporting telephony services over a data network. A communication network establishes a voice session from a calling station to a called station associated with a user. A service platform, in communication with the communication network, obtains Caller ID information corresponding to the voice session, and determines an instant communication client of the user. The Caller ID information is transmitted over the data network to the instant communication client for display of the Caller ID information. 1. A system comprising:a service platform in communication with a communication network, the service platform being configured to obtain Caller Identification (Caller ID) information corresponding to a voice session established over the communication network from a calling station to a called station associated with a user, and to determine an instant communication client of the user,wherein the Caller ID information is transmitted over a data network to the instant communication client for display of the Caller ID information.2. A system according to claim 1 , wherein the called station is among a plurality of called stations associated with the user claim 1 , and the service platform obtains another Caller ID information associated with a different called station claim 1 , the other Caller ID information being forwarded to the instant communication client claim 1 , the instant communication client displaying the plurality of Caller ID information concurrently.3. A system according to claim 1 , wherein the instant communication client is among a plurality of instant communication clients claim 1 , and the service platform forwards the Caller ID information to one or more of the instant communication clients.4. A system according to claim 1 , further comprising:a user database accessible by the service platform and configured to store a profile of the user, wherein the profile specifies the called station for monitoring and the instant ...

Remote management of aircraft computer systems

The present invention includes system and methods for managing information systems on an aircraft through the use of a remote management center. At the management center, the status information from aircraft computer systems is monitored for fault conditions. The management center then performs maintenance on the computer system when a fault condition is noticed. Exemplary systems include a remote management center that manages several different computer systems on several different manned aircraft. The management center connects to the aircraft and computer system through data links.

On-line directory assistance system

An approach for providing an on-line directory assistance services is disclosed. An on-line directory assistance system includes a server that receives a request message for information over a packet switched network from an access device. The server forwards the information to the access device in response to the request message, wherein the information includes basic content data and optional enhanced content data. The system also includes a database that stores the information. Further, the server selectively receives a modification message to modify the enhanced content data associated with the information from the access device. The server then updates the database based upon the modification message.

Digital media asset management system and method for supporting multiple users

An approach provides editing of digital media. A platform, as maintained by a service provider, provides a remote proxy editing capability of a plurality of media streams. A first one of the media streams is transmitted to a player of a first customer of the service provider. Further, the method comprises transmitting a second one of the media streams to a player of a second customer of the service provider.

Method for charging on-line directory assistance services

An approach for providing an on-line directory assistance service system for charging for directory assistance services that are provided over a packet switched network is disclosed. The system includes a server that tracks the number of directory listings that are transmitted to and displayed on a client access device (e.g., non-PC devices) and to prepare billing information based upon the number of directory listings. The system also includes a database that is coupled to the server and that stores the directory listings.

Providing of presence information to a telephony services system

In support of an interactive telephony services system, a presence gateway provides presence information regarding availability of a called party to communicate using an instant communications client.

Messaging response system

A messaging response system is disclosed wherein a service providing system provides services to users via messaging communications. In accordance with an exemplary embodiment of the present invention, multiple respondents servicing users through messaging communications may appear to simultaneously use a common screen name identifier.

Method and system for providing conferencing services

An approach is provided for supporting multi-media conferencing. Textual information (e.g., text associated with a presentation) is received for display during a conference session to multiple participants. For a particular participant, configuration information corresponding to the participant specifies language assistance for the textual information. Language assistance involves augmenting the textual information according to the configuration information for comprehension of the textual information by the particular participant. In one embodiment, the augmented textual information includes language translation of the textual information. Additionally, the augmented textual information can encompass definitions of terms, including acronyms. The augmented textual information is forwarded for display to the participant during the conference session.

Stateless mechanism for data retrieval

An approach for providing retrieval of information over a packet switched network is disclosed. A client is configured to transmit a request message for information over the packet switched network. A stateless-server is configured to communicate with the client and to forward a portion of the information to the client in response to the request message, wherein the client transmits a selection message specifying whether the remaining portion of the information should be retrieved from the server. The server selectively forwards the remaining portion of the information to the client. The above approach has particular applicability to a communication system providing directory assistance services.

Call completion via instant communications client

A system is disclosed for achieving completion of a telephone call by way of an instant communications client.

Method and system for providing universal relay services

An approach for providing instant messaging (IM) services is disclosed. A request is received from a source client to establish communication with a destination client associated with a subscriber over a first IM environment, wherein the request specifies a first user name derived from a unique identifier of the subscriber. A unique identifier is determined from the first user name. Further, a profile of the subscriber is accessed based on the unique identifier to determine a second user name corresponding to a second IM environment. An IM session is established between the source client and the destination client over the first and second IM environments using the respective first user name and second user name.

System and method for providing prepaid services via an internet protocol network system

A system and method are disclosed for providing prepaid services via an open network architecture system having access to a network, such as the Internet via an Internet protocol. The architecture system is operated by a system operator and includes a customer profile database which stores various customer-related information, such as customer names and their respective payment and contact information, a plurality of databases each storing prepaid accounts for a particular prepaid service, such as telephony, Internet access, paging, and cellular, and web-site system hardware connected to the customer profile database and the plurality of databases and to a network, such as the Internet, for ubiquitously accessing the databases via the Internet for viewing and managing one's prepaid services, as well as purchasing additional prepaid services and/or usage rights. The architecture system further includes network hardware connected to the web-site system hardware for enabling outside system ...

HE4 Based Therapy For Malignant Disease

The invention provides compositions and methods for utilizing human epididymal secretory protein E4 (HE4) in the prevention and treatment of cancer and other human diseases.

Method and system for extended directory service

An approach is disclosed for providing an extended directory service over a communication system including a data network and a telephony network. A subscriber submits a request for directory information to the communication system according to a first communication mode. The system accesses a directory among multiple directories in response to the request, wherein the directories include an internal directory associated with the subscriber and an external directory not associated with the subscriber. The directory information from the selected directory is retrieved and forwarded to the subscriber according to a second communication mode.

Telephony services system with instant communications enhancements

An interactive telephony services system is provided with instant communications function. In accordance with some embodiments, presence information related to the availability of a called party to be contacted via instant communications affects the handling of telephone calls to the called party. In accordance with some embodiments, a telephone call may be connected to an instant communications client used by a called party.

Digital media asset management system and method for supporting multiple users

An approach provides editing of digital media. A platform, as maintained by a service provider, provides a remote proxy editing capability of a plurality of media streams. A first one of the media streams is transmitted to a player of a first customer of the service provider. Further, the method comprises transmitting a second one of the media streams to a player of a second customer of the service provider.

Communication converter for converting audio information/textual information to corresponding textual information/audio information

A communication converter is described for converting among speech signals and textual information, permitting communication between telephone users and textual instant communications users.

METHOD AND SYSTEM FOR PROVIDING CONFERENCING SERVICES

An approach is provided for supporting multi-media conferencing. Textual information (e.g., text associated with a presentation) is received for display during a conference session to multiple participants. For a particular participant, configuration information corresponding to the participant specifies language assistance for the textual information. Language assistance involves augmenting the textual information according to the configuration information for comprehension of the textual information by the particular participant. In one embodiment, the augmented textual information includes language translation of the textual information. Additionally, the augmented textual information can encompass definitions of terms, including acronyms. The augmented textual information is forwarded for display to the participant during the conference session. 1. A method comprising:determining that textual information corresponds to a predetermined term and associated supplemental information that includes a definition of the term, wherein the textual information is to be presented to one of a plurality of participants of a conference session;marking the textual information to notify the one participant that the supplemental information is available for presentation based on the determination; andforwarding the textual information having the marking to the one participant for presentation during the conference session.2. A method according to claim 1 , further comprising:determining that the one participant requires language assistance for the textual information.3. A method according to claim 2 , further comprising:translating the textual information according to a type of language for the one participant during the conference session.4. A method according to claim 1 , wherein the term includes an acronym.5. A method according to claim 1 , further comprising:generating a plurality of invitation messages to transmit to the participants; anddetermining confirmation status of ...

Universal communications identifier

An approach is provided for supporting a plurality of communication modes through universal identification. A core identifier is generated for uniquely identifying a user among a plurality of users within the communication system. One or more specific identifiers are derived based upon the core identifier, wherein the specific identifiers serve as addressing information to the respective communication modes. The specific identifiers and the core identifier are designated as a suite of identifiers allocated to the user.

Call completion via instant communications client

A system is disclosed for achieving completion of a telephone call by way of an instant communications client.

METHOD AND SYSTEM FOR PROVIDING A PERSONAL VIDEO RECORDER UTILIZING NETWORK-BASED DIGITAL MEDIA CONTENT

An approach provides for recording and editing digital media. A digital media stream is generated from an input signal (such as a live broadcast feed). The digital media stream is transmitted to a browser application configured to concurrently record and edit the digital media stream.

Adamantyl Derivatives as Therapeutic Agents

The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis.

On-line directory assistance system

An approach for providing an on-line directory assistance services is disclosed. An on-line directory assistance system includes a server that receives a request message for information over a packet switched network from an access device. The server forwards the information to the access device in response to the request message, wherein the information includes basic content data and optional enhanced content data. The system also includes a database that stores the information. Further, the server selectively receives a modification message to modify the enhanced content data associated with the information from the access device. The server then updates the database based upon the modification message.

Universal communications identifier

An approach is provided for supporting a plurality of communication modes through universal identification. A core identifier is generated for uniquely identifying a user among a plurality of users within the communication system. One or more specific identifiers are derived based upon the core identifier, wherein the specific identifiers serve as addressing information to the respective communication modes. The specific identifiers and the core identifier are designated as a suite of identifiers allocated to the user.

COMMUNICATION CONVERTER FOR CONVERTING AUDIO INFORMATION/TEXTUAL INFORMATION TO CORRESPONDING TEXTUAL INFORMATION/AUDIO INFORMATION

A communication converter is described for converting among speech signals and textual information, permitting communication between telephone users and textual instant communications users.

PROVIDING OF PRESENCE INFORMATION TO A TELEPHONY SERVICES SYSTEM

In support of an interactive telephony services system, a presence gateway provides presence information regarding availability of a called party to communicate using an instant communications client.

METHOD AND SYSTEM FOR DYNAMIC CONTROL OF DIGITAL MEDIA CONTENT PLAYBACK AND ADVERTISEMENT DELIVERY

An approach provides control of digital media. A stream of digital media that includes an advertisement is received. The stream is selectively skipped to avoid the advertisement. In addition, the amount of advertisement played back is tracked. Further, tracking information is generated based on the tracking.

Method and system for providing a personal video recorder utilizing network-based digital media content

An approach provides for recording and editing digital media. A digital media stream is generated from an input signal (such as a live broadcast feed). The digital media stream is transmitted to a browser application configured to concurrently record and edit the digital media stream.

Adamantyl derivatives as therapeutic agents

The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis.

Communications gateway with messaging communications interface

Methods and devices are disclosed which provide for a communications gateway to be operatively coupled to a messaging system. In accordance with an exemplary embodiment of the present invention, communications are established via the gateway responsive at least to messaging communications involving the communications gateway.

Method and system for extended directory service

An approach is disclosed for providing an extended directory service over a communication system including a data network and a telephony network. A subscriber submits a request for directory information to the communication system according to a first communication mode. The system accesses a directory among multiple directories in response to the request, wherein the directories include an internal directory associated with the subscriber and an external directory not associated with the subscriber. The directory information from the selected directory is retrieved and forwarded to the subscriber according to a second communication mode.

Comprehensive communication services system

An approach is provided for offering communication services supported by a data network and a telephony network. A primary identifier is assigned to a user for access to the communication services, wherein the primary identifier is used by a party seeking to communicate with the user via one of the communication services. The primary identifier is mapped to one of a plurality of secondary identifiers corresponding to the respective communication services. The one secondary identifier is used by at least one of the data network and the telephony network to establish a communication session between the party and the user.

Adamantyl Derivatives as Therapeutic Agents

The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis. 2. The compound of claim 1 , wherein Ris unsubstituted or substituted C-Calkyl and Rand Rare each hydrogen.3. The compound of claim 2 , wherein Xis S and Xis 0.4. The compound of claim 3 , wherein m and n are each 1 and p is 0.5. The compound of claim 4 , wherein Ris —C(O)OR.6. The compound of claim 1 , wherein R claim 1 , Rand Rare each claim 1 , independently claim 1 , hydrogen claim 1 , nitro claim 1 , unsubstituted or substituted C-Calkyl claim 1 , unsubstituted or substituted C-Caryl claim 1 , unsubstituted or substituted heteroaryl comprising 1-4 heteroatoms selected from N claim 1 , O and S claim 1 , unsubstituted or substituted C-Calkenyl claim 1 , unsubstituted or substituted Calkynyl claim 1 , hydroxyl claim 1 , halogen claim 1 , or —NRR.7. The compound of claim 1 , wherein m claim 1 , n and p are each claim 1 , independently claim 1 , integers from 0 to 10.10. The compound of claim 9 , wherein Rand R are each claim 9 , independently claim 9 , a bond or unsubstituted or substituted C-Calkyl.11. The compound of claim 10 , wherein both (AA)and (AA) claim 10 , comprise one or more α-amino acids.12. The compound of claim 11 , wherein q and r are each claim 11 , independently claim 11 , integers from 1 to 10.13. The compound of claim 12 , wherein q and r are each claim 12 , independently claim 12 , integers from 1 to 5.14. A method for treating cancer in a subject in need of such treatment claim 1 , the method comprising administering to said subject a therapeutically effective amount of a compound of .15. The method of claim 14 , wherein the cancer is selected from the group consisting of: neuroblastoma claim 14 , ovarian cancer claim 14 , breast cancer claim 14 , cervical cancer claim 14 , endometrial cancer claim 14 , prostate cancer claim 14 , pancreatic cancer ...

Novel 7-Dehydrocholesterol Derivatives and Methods Using Same

The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof. 4. The compound of claim 1 , wherein Ris N.5. The compound of claim 4 , wherein Ris N(R).8. The compound of claim 5 , wherein Ris selected from the group consisting of —O(CR)R claim 5 , —OC(═O)(CR)R claim 5 , —OC(═O)(CR)OR claim 5 , and —OC(═O)C(R)═C(R).10. The compound of claim 1 , wherein Ris CR.11. The compound of claim 10 , wherein Ris selected from the group consisting of H claim 10 , alkyl claim 10 , substituted alkyl claim 10 , cycloalkyl claim 10 , substituted cycloalkyl claim 10 , arylalkyl claim 10 , substituted arylalkyl claim 10 , heteroarylalkyl claim 10 , and substituted heteroarylalkyl.12. The compound of claim 10 , wherein Ris selected from the group consisting of R claim 10 , —O(CR)R claim 10 , OC(═O)(CR)R claim 10 , and OC(═O)C(R)═C(R); or Ris selected from the group consisting of ═O and ═S claim 10 , and H* is omitted.13. The compound of claim 1 , wherein n is 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 or 5.14. The compound of claim 1 , wherein the salt is an acid addition salt and is selected from the group consisting of sulfate claim 1 , hydrogen sulfate claim 1 , hydrochloric claim 1 , hydrobromic claim 1 , hydriodic claim 1 , nitric claim 1 , carbonic claim 1 , sulfuric claim 1 , phosphoric claim 1 , formic claim 1 , acetic claim 1 , propionic claim 1 , succinic claim 1 , glycolic claim 1 , gluconic claim 1 , lactic claim 1 , malic claim 1 , tartaric claim 1 , citric claim 1 , ascorbic claim 1 , glucuronic claim 1 , maleic claim 1 , fumaric claim 1 , pyruvic claim 1 , aspartic claim 1 , glutamic claim 1 , benzoic claim 1 , ...

THERAPY FOR MALIGNANT DISEASE

Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression. 1. A method of suppressing tumor cell growth in a subject comprising: concurrently or sequentially inhibiting(a) the activity or level of human epididymal secretory protein E4 (HE4) in said tumor cell; and(b) the activity or level of one or more immune checkpoint inhibitors (ICIs) in the cell, thereby suppressing tumor cell growth in said subject.2. The method of claim 1 , wherein said tumor cell comprises a malignant tumor cell.3. The method of claim 1 , wherein said tumor cell comprises a Müllerian cancer cell.4. The method of claim 2 , wherein said malignant tumor cell an ovarian cancer cell claim 2 , an endometrial cancer cell claim 2 , or a breast cancer cell.5. The method of claim 1 , wherein said level of HE4 in said tumor cell is inhibited by administering an effective amount of an HE4 inhibitor to said tumor cell.6. The method of claim 5 , wherein said HE4 inhibitor comprises a neutralizing anti-HE4 antibody claim 5 , an antisense oligonucleotide claim 5 , a small interfering ribonucleic acid (siRNA) claim 5 , a small hairpin RNA (shRNA) claim 5 , a non-antibody binding polypeptide claim 5 , or a small molecule chemical compound.8. The method of claim 6 , wherein said HE4 inhibitor comprises an antisense oligonucleotide.9. The method of claim 8 , wherein the antisense oligonucleotide comprises a Locked Nucleic Acid (LNA) longRNA GAPmer comprising a sequence of 5′-TTGCTGAAAGTGGTTA-3 ...

SEPTIN INHIBITORS FOR TREATMENT OF CANCERS

The present disclosure provides novel compounds, compositions, and methods for modulating one or more septin proteins, e.g., septin-2. Such compounds and compositions are useful for the treatment of a cancer, e.g., endometrial, pancreatic, lung, breast or ovarian cancer, such as serous and ovarian clear cell carcinoma. 2. (canceled)3. The compound of claim 1 , wherein Xis N.4. The compound of claim 3 , wherein both Xand Xare C.8. The compound of claim 1 , wherein{'sup': 1', '11', '11', '11', '11, 'sub': 2', '2', '1', '6', '1', '6, 'Ris F, Cl, Br, I, NO, (C═O)—R, (C═O)—OR, (C═O)—NHR, (C═O)—N(R), or C-Calkyl, wherein the C-Calkyl optionally comprises one, two, three, or more substitutions with F, Cl, Br, I, or phenyl.'}9. The compound of claim 1 , wherein{'sup': 2', '11', '11', '11', '11, 'sub': 2', '2', '1', '6', '1', '6, 'Ris F, Cl, Br, I, NO, (C═O)—R, (C═O)—OR, (C═O)—NHR, (C═O)—N(R), or C-Calkyl, wherein the C-Calkyl optionally comprises one, two, three, or more substitutions with F, Cl, Br, I, or phenyl.'}10. The compound of claim 1 , wherein{'sup': 1', '2, 'sub': 1', '6', '1', '6, 'each of Rand Ris independently F, Cl, Br, I, or C-Calkyl, wherein the C-Calkyl optionally comprises one, two, three, or more substitutions with F, Cl, Br, I, or phenyl.'}11. The compound of claim 1 , wherein{'sup': '12', 'Ris an ortho substituent.'}12. The compound of claim 1 , wherein{'sup': '12', 'sub': 1', '6', '1', '6, 'each Ris F, Cl, Br, I, or C-Calkyl, wherein the C-Calkyl optionally comprises one, two, three, or more substitutions with F, Cl, Br, or I.'}13. The compound of claim 1 , wherein{'sup': '11', 'sub': 1', '6', '2', '6', '2', '6', '6', '10', '1', '6', '2', '6', '2', '6', '6', '10', '1', '6', '1', '6', '1', '6', '1', '6', '2, 'each Ris independently C-Calkyl, C-Calkenyl, C-Calkynyl, C-Caryl or 5-10 membered heteroaryl, wherein the C-Calkyl, C-Calkenyl, C-Calkynyl, C-Caryl or 5-10 membered heteroaryl optionally comprises one, two, three, or more substitutions with F, Cl, ...

Adamantyl Derivatives as Therapeutic Agents

The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis.

SEPTIN PROTEINS AS NOVEL BIOMARKERS FOR DETECTION AND TREATMENT OF MÜLLERIAN CANCERS

Provided herein, inter alia, are septin family proteins as novel biomarkers for the detection of Müllerian cancers such as ovarian, fallopian tube, primary peritoneal, endometrial and uterine cancers as well as therapeutics targeting of septin-2 and other septin family genes and proteins via small molecule, antisense or antibody targeted treatment for treatment of the same. Thus, provided herein are molecular tools and methods for diagnosing Müllerian cancers and for identifying subjects with an increased likelihood of having Müllerian cancers. 1. A method for diagnostically evaluating a subject for Müllerian cancer , said method comprising: measuring the expression of a septin family gene or protein or fragment thereof in a sample from the subject , wherein the subject is diagnosed with Müllerian cancer if the expression of the septin family gene or protein or fragment thereof is higher in the sample than in one or more control samples acquired from one or more subjects without Müllerian cancer.2. The method of claim 1 , further comprising measuring the expression of a gene or protein or fragment thereof of one or more biomarkers selected from the group consisting of CA125 claim 1 , p21 claim 1 , HE4 claim 1 , transthyretin claim 1 , LPA claim 1 , YKL-40 and inhibin claim 1 , wherein the subject is diagnosed with Müllerian cancer if a) the expression of the septin family gene or protein or fragment thereof and b) the expression of said gene or protein or fragment thereof of said one or more biomarkers is higher in the sample than in said one or more control samples acquired from one or more subjects without Müllerian cancer.3. The method of or claim 1 , wherein said subject is pre- or post-menopausal.4. The method of any one of - claim 1 , wherein said subject has been diagnosed as having a Müllerian cancer and said method is used to determine if said Müllerian cancer has recurred or advanced.5. The method of any one of - claim 1 , wherein said subject has not been ...

NOVEL 7-DEHYDROCHOLESTEROL DERIVATIVES AND METHODS USING SAME

The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof. 119.-. (canceled)23. The method of claim 20 , wherein Ris N.24. The method of claim 23 , wherein Ris N(R).27. (canceled)29. The method of claim 20 , wherein the cancer comprises one selected from the group consisting of breast cancer claim 20 , prostate cancer claim 20 , ovarian cancer claim 20 , cervical cancer claim 20 , skin cancer claim 20 , pancreatic cancer claim 20 , colorectal cancer claim 20 , renal cancer claim 20 , liver cancer claim 20 , brain cancer claim 20 , lymphoma claim 20 , leukemia claim 20 , lung cancer claim 20 , endometrial cancer claim 20 , neuroblastoma claim 20 , and any combinations thereof.30. The method of claim 29 , wherein the cancer comprises one selected from the group consisting of prostate cancer claim 29 , breast cancer claim 29 , ovarian cancer claim 29 , endometrial cancer claim 29 , medulloblastoma claim 29 , neuroblastoma claim 29 , melanoma.31. The method of claim 20 , wherein the subject is further administered at least one additional chemotherapeutic agent.32. The method of claim 31 , wherein at least one agent comprises is selected from the group consisting of alkylating agents; nitrosoureas; antimetabolites; antitumor antibiotics; plant alkyloids; taxanes; hormonal agents; anti-angiogenesis agents claim 31 , and miscellaneous agents.33. The method of claim 31 , wherein the compound and the agent are separately administered to the subject.34. The method of claim 31 , wherein the compound and the agent are coadministered to the subject.35. The method of claim 20 , wherein the subject is a mammal.36. The ...

NOVEL 7-DEHYDROCHOLESTEROL DERIVATIVES AND METHODS USING SAME

The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof.

Method and Systems for Providing Conferencing Services

An approach is provided for supporting multi-media conferencing. Textual information (e.g., text associated with a presentation) is received for display during a conference session to multiple participants. For a particular participant, configuration information corresponding to the participant specifies language assistance for the textual information. Language assistance involves augmenting the textual information according to the configuration information for comprehension of the textual information by the particular participant. In one embodiment, the augmented textual information includes language translation of the textual information. Additionally, the augmented textual information can encompass definitions of terms, including acronyms. The augmented textual information is forwarded for display to the participant during the conference session. 1. An apparatus for annotating a conference session transmitted over a network , the apparatus comprising: process media of activity that occurs during the conference session, the conference session having an associated timeline;', 'receive an annotation associated with a point of the conference session from a user input;', 'obtain time stamp information for the point of the conference session associated with the timeline thereof;', 'associate the time stamp information with the annotation, such that subsequent playback of the media will cause the annotation to be presented in accordance with the time stamp information., 'one or more processing devices configured to2. The apparatus of claim 1 , wherein the annotation is received after the conference session has concluded.3. The apparatus of claim 1 , wherein the annotation is received from a participant of the conference session claim 1 , and the one or more processing devices are further configured to receive a list of recipients of the annotation.4. The apparatus of claim 3 , wherein the list of recipients is limited to the participant such that the annotation is a ...

Septin proteins as novel biomarkers for detection and treatment of müllerian cancers

Provided herein, inter alia , are septin family proteins as novel biomarkers for the detection of Müllerian cancers such as ovarian, fallopian tube, primary peritoneal, endometrial and uterine cancers as well as therapeutic targeting of septin-2 and other septin family genes and proteins via small molecule, antisense or antibody targeted treatment for treatment of the same. Thus, provided herein are molecular tools and methods for diagnosing Müllerian cancers and for identifying subjects with an increased likelihood of having Müllerian cancers.

Therapy for malignant disease

Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression.

Call completion via instant communications client

HE4 based therapy for malignant disease

The invention provides compositions and methods for utilizing human epididymal secretion protein E4 (HE4) in the prevention and treatment of cancer and other human diseases.

Rotary valve system for internal combustion engines

A fuel-air compression and timing device for an internal combustion engine of the Ottoman, four-stroke type wherein triangular rotors are in phased relationship with the pistons of the engine to sequence the intake and exhaust strokes and to provide a double compression of the fuel-air mixture by the rotors and the pistons.

Therapy for malignant disease comprising the inhibition of human epididymal secretory protein e4 and immune checkpoint inhibitors

Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression.

Stateless mechanism for data retrieval

Telephony services system with instant communications enhancements

Systems, methods and program products are disclosed for determining billable usage of a communication system (10) wherein services are provided via instant communications (14). In some embodiments, the present invention provides for authorizing the fulfillment of service requests based upon information pertaining to a billable account.

Media translator

Novel 7-Dehydrocholesterol Derivatives and Methods Using Same

The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof.

Method for charging on-line directory assistance services

An approach for providing an on-line directory assistance service system for charging for directory assistance services that are provided over a packet switched network. The system includes a server (106) that tracks the number of directory listings that are transmitted to and displayed on a client access device (114) and to prepare billing information based upon the number of directory listings. The system also includes a database (104) that is coupled to the server (106) and that stores the directory listings.

ONLINE DIRECTORY ASSISTANCE SYSTEM

System and method for providing prepaid services via an internet protocol network system

A system and method are disclosed for providing prepaid services via an open network architecture system having access to a network, such as the Internet via an Internet protocol. The architecture system is operated by a system operator and includes a customer profile database which stores various customer-related information, such as customer names and their respective payment and contact information, a plurality of databases each storing prepaid accounts for a particular prepaid service, such as telephony, Internet access, paging, and cellular, and web-site system hardware connected to the customer profile database and the plurality of databases and to a network, such as the Internet, for ubiquitously accessing the databases via the Internet for viewing and managing one's prepaid services, as well as purchasing additional prepaid services and/or usage rights. The architecture system further includes network hardware connected to the web-site system hardware for enabling outside system operators, e.g., wholesalers, online retailers, system developers and ISPs, to utilize the architecture system to brand their own prepaid services and offer them through the architecture system.

Method and system for providing distributed editing and storage of digital media over a network

An approach provides distributed editing and storage of digital media. Video information is retrieved during recording of the video information to a video file. The video information is edited during the recording of the video information. An index file for the media is generated during the recording of the media, wherein the index file include indices for decoding the media; and periodically updating the index file throughout the recording of the media. After completion of the recording of the media, another index file is generated corresponding to the media for inclusion into the media file.

Enhanced services call completion

Methods are disclosed for achieving completion of a telephone call by way of an instant communications client (139).

Comprehensive communication system

Therapy for malignant disease comprising the inhibition of human epididymal secretory protein e4 and immune checkpoint inhibitors

Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression.

Method for charging on-line directory assistance services

An approach for providing an on-line directory assistance service system for charging for directory assistance services that are provided over a packet switched network. The system includes a server (106) that tracks the number of directory listings that are transmitted to and displayed on a client access device (114) and to prepare billing information based upon the number of directory listings. The system also includes a database (104) that is coupled to the server (106) and that stores the directory listings.

Method for charging on-line directory assistance services

An approach for providing an on-line directory assistance service system for charging for directory assistance services that are provided over a packet switched network. The system includes a server (106) that tracks the number of directory listings that are transmitted to and displayed on a client access device (114) and to prepare billing information based upon the number of directory listings. The system also includes a database (104) that is coupled to the server (106) and that stores the directory listings.

Telephony services system with instant communications enhancements

An interactive telephony services system is provided with instant communications function. In accordance with some embodiments, presence information related to the availability of a called party to be contacted via instant communications affects the handling of telephone calls to the called party. In accordance with some embodiments, a telephone call may be connected to an instant communications client used by a called party (137).

Online-verzeichnis-unterstützungssystem

Verfahren zur vergebührung von online-rufnummern- auskunftsdiensten

7-dehydrocholesterol derivatives and methods using same

The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as in treating or preventing uncontrolled angiogenesis, in a subject. In certain embodiments of the present invention, the subject is a human. In other aspects, the present invention provides a method of preparing compounds of the invention, or a salt or solvate thereof.

Method and system for providing conferencing services

An approach is provided for supporting multi-media conferencing. Textual information (e.g., text associated with a presentation) is received for display during a conference session to multiple participants. For a particular participant, configuration information corresponding to the participant specifies language assistance for the textual information. Language assistance involves augmenting the textual information according to the configuration information for comprehension of the textual information by the particular participant. In one embodiment, the augmented textual information includes language translation of the textual information. Additionally, the augmented textual information can encompass definitions of terms, including acronyms. The augmented textual information is forwarded for display to the participant during the conference session.

Real time and in-flight dynamic personalization of an aircraft

A method and system for dynamically personalizing an aircraft is provided. Users of an aircraft store their environmental preferences in a file on a storage device. When the users use the aircraft or ride on the aircraft, the aircraft computer system communicates with and uploads the users' files containing the users' environmental preferences. The aircraft computer system then implements the users' preferences by configuring a system of modules.

Dynamic resource allocation

The present invention includes systems and methods for dynamic allocation of computing resources. Computing resources on an aircraft are divided amongst several avionics applications that are responsible for controlling sub-systems on the aircraft (e.g. the navigation system). A resource manager assigns computing resources (e.g. processor cycles) to individual applications based on the present condition of the aircraft and then instructs the throttling mechanisms to allocate the computing resources among the applications. The resource manager determines the aircraft condition by correlating inputs from the aircraft to a set of rules stored in a condition table. The resource manager then determines the computing resource allocation by correlating the aircraft condition to a set of resource allocations stored in an allocation table.