03-07-2014 дата публикации
Номер: US20140186329A1
Принадлежит:
The present invention provides methods of use of polyphenol compounds for treating, preventing, mitigating and delaying ischemia or a condition where ischemia occurs. In one embodiment, the method comprises providing a polyphenol analog; and administering the polyphenol analog to a subject to treat ischemia or a condition where ischemia occurs. Various embodiments of the present invention are useful for the treatment of patients having, or at risk for, any of (1) ischemic stroke, (2) hemorrhagic stroke, (3) cardiovascular disease, (4) ischemia related spinal cord injury, (5) ischemia in diabetic patients, or (6) embolic stroke. For example, use of the polyphenol compounds can maintain glutathione levels in the patient. 3. The method of claim 2 , wherein:{'sup': 1', '2', 'a', '3', '4, 'sub': 1-6', '1-6', '3-8', '4-11', '6-10', '7-16, '(a) the compound is of Formula IIA, and wherein each of Rand R, independent of the other, is —OR; Ris H or optionally substituted Calkyl; and Ris Calkyl, Ccycloalkyl, Ccycloalkylalkyl, Caryl or Carylalkyl;'}{'sup': 1', '2', 'a', '3', 'a, 'sub': '1-6', '(b) the compound is of Formula IIIA, and wherein each of Rand R, independent of the other, is —OR; Ris H, Calkyl or —OR;'}{'sup': 1', '2', '1', '2', 'a', 'c', '3', '4, 'sub': 1-6', '2', '1-6', '1-6', '3-8', '4-11', '6-10', '7-16, '(c) the compound is of Formula IIA, and wherein one of Rand Ris optionally substituted Calkyl and the other of Rand Ris H, —ORor —N(R); Ris H or optionally substituted Calkyl; and Ris Calkyl, Ccycloalkyl, Ccycloalkylalkyl, Caryl or Carylalkyl;'}{'sup': 1', '2', '1', '2', 'a', 'c', '3', 'a, 'sub': 1-6', '2', '1-6, '(d) the compound is of Formula IIIA, and wherein one of Rand Ris optionally substituted Calkyl and the other of Rand Ris H, —ORor —N(R); and Ris H, Calkyl or —OR;'}{'sup': 1', '2', 'a', '1', '2', 'c', '1', '2', '3', '4, 'sub': 2', '1-6', '1-6', '3-8', '4-11', '6-10', '7-16, '(e) the compound is of Formula IIA, and wherein one of Rand Ris H or —ORand ...
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