ANTIMICROBIAL AND STRENGTHENED-GLASS ARTICLES THROUGH PRESSURIZED ION EXCHANGE

A method of treating a substrate in a pressure vessel that includes the steps: preparing an ion-exchange bath with a bath composition that comprises a polar solvent and a plurality of ion-exchanging ions in a vessel; submersing a substrate having an outer region containing a plurality of exchangeable ions in the bath; pressurizing the bath in the vessel to a predetermined pressure substantially above ambient pressure; heating the bath in the vessel to a predetermined temperature; and treating the substrate for a predetermined ion-exchange duration at the predetermined pressure and temperature such that a portion of the plurality of exchangeable ions is exchanged with a portion of the ion-exchanging ions. The substrate can consist essentially of a glass, glass-ceramic or ceramic substrate composition, and the predetermined ion-exchange duration, temperature and pressure can each be selected based at least in part on the substrate composition and the bath composition.

FUNCTIONALIZED CELL BINDING PEPTIDES AND CELL CULTURE ARTICLES

Synthetic surfaces capable of supporting culture of cells in culture, particularly cells that will be used therapeutically, are disclosed. The synthetic cell culture surfaces have a functionalized peptide, a peptide that has been functionalized to contain a polymerization moiety, and optionally a spacer, grafted to a hydrophilic polymeric base material. Methods of making the surfaces and methods of using the surfaces are also disclosed. 1. A functionalized peptide comprising:{'sub': m', 'p', 'ap, 'a composition of the formula R—S—C'}wherein R is a polymerization moiety selected from the group consisting of acrylate, methacrylate, acrylamide, methyacrylamide, maleimide, fumarate and epoxide and combinations, and m is an integer equal to or greater than 1; and,{'sub': p', '2', 'm2', '3', 'n, 'wherein Sis a spacer moiety wherein the spacer moiety comprises polyethylene oxide or polypropylene oxide having the formula (O—CHCHR′)where R′ is H or CHand m2 is an integer from 1 to 20, or Xaawherein Xaa is independently any amino acid and n is an integer from 0 to 20, or a combination; and'}{'sub': 'ap', 'wherein Cis a peptide comprising a cell adhesive sequence.'}2. The functionalized peptide of wherein Scomprises a Lys or Arg amino acid.3. The functionalized peptide of wherein the cell adhesive peptide (C) comprises the sequence: KGGGQKCIVQTTSWSQCSKS (SEQ ID NO:1); GGGQKCIVQTTSWSQCSKS(SEQ ID NO:2); KYGLALERKDHSG (SEQ ID NO:3); YGLALERKDHSG (SEQ ID NO:4); KGGSINNNRWHSIYITRFGNMGS (SEQ ID NO:5); GGSINNNRWHSIYITRFGNMGS (SEQ ID NO:6); KGGTWYKIAFQRNRK (SEQ ID NO:7); GGTWYKIAFQRNRK (SEQ ID NO:8); KGGTSIKIRGTYSER (SEQ ID NO:9); GGTSIKIRGTYSER (SEQ ID NO:10); KYGTDIRVTLNRLNTF (SEQ ID NO:11); YGTDIRVTLNRLNTF (SEQ ID NO:12); KYGSETTVKYIFRLHE (SEQ ID NO:13); YGSETTVKYIFRLHE (SEQ ID NO:14); KYGKAFDITYVRLKF (SEQ ID NO:15); YGKAFDITYVRLKF (SEQ ID NO:16); KYGAASIKVAVSADR (SEQ ID NO:17); YGAASIKVAVSADR (SEQ ID NO:18); KGGNGEPRGDTYRAY (SEQ ID NO:19); GNGEPRGDTYRAY (SEQ ID NO:20); ...

Swellable (meth)acrylate surfaces for culturing cells in chemically defined media

Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol)dimethacrylate. The conjugated peptide may include an amino acid sequence of Xaa n ProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.

Thermally stable and electrically isolating barrier film

A thermoset barrier film including: a reaction product of the formulas (I), (II), (III), (IV), or a mixture thereof, as defined herein. Also disclosed are methods of making and using the thermoset barrier film, and devices incorporating the thermoset barrier film.

ELECTRICALLY ISOLATING POLYMER COMPOSITION

An electrode coating composition that includes at least one crosslinkable monomer; at least one hydrophobic monomer; and at least one dielectric constant enhancing agent selected from dielectric enhancing monomers, ferroelectric particulates, and electroactive polymers. Coatings including the polymer of compositions, and articles including electrically isolating layers are also disclosed. 1. An electrode coating composition comprising: from 5 to 30 wt % of at least one crosslinkable monomer;', 'from 20 to 85 wt % of at least one hydrophobic monomer; and', 'at least one dielectric constant enhancing agent in from 2 to 60 wt %, based on the total weight of the coating composition,', 'wherein the one dielectric constant enhancing agent comprises a mixture of an electroactive polymer in from 2 to 20 wt % and a dielectric enhancing monomer in from 10 to 60 wt %, the coating has a dielectric constant of from 1.5 to 10 and has a breakdown voltage property of from 750 to 1,800 volts per micron., 'a polymerized product of2. The coating composition of claim 1 , wherein:the electroactive polymer is polyaniline and is present in from 5 to 10 wt %;the dielectric enhancing monomer is furfuryl methacrylate and is present in from 8 to 25 wt %the at least one hydrophobic monomer has from 6 to 23 carbon atoms; andthe at least one crosslinkable monomer is a methacryl polyhedral oligomeric silsesquioxane, acryl polyhedral oligomeric silsesquioxane, or a mixture thereof, and is present in from 5 to 30 wt %, based on the total weight of the composition.3. The coating composition of claim 1 , wherein the electrode coating has a thickness of from 10 nm to 1 mm.5. The coating composition of claim 1 , wherein:the at least one crosslinkable monomer is a dipentaerythritol pentacrylate in from 10 to 30 wt %;the at least one hydrophobic monomer is 2,2,3,3,3-pentafluoropropyl acrylate in from 45 to 85 wt %; andthe at least one dielectric constant enhancing agent is furfuryl methacrylate in from ...

Methods and Apparatus Providing A Substrate and Protective Coating Thereon

Methods and apparatus are provide for: a glass substrate having first and second opposing surfaces, and a plurality of edge surfaces extending transversely between the first and second opposing surfaces; a layer disposed on, and adhered to, at least one of the first, second, and edge surfaces of the substrate, where the layer includes: (i) one of an oligomer and resin; (ii) a monomer; and (iii) nanometer-sized silica particles of at least about 2-50 weight percent. 1. An apparatus , comprising:a glass substrate having first and second opposing surfaces, and a plurality of edge surfaces extending transversely between the first and second opposing surfaces;a layer disposed on, and adhered to, at least one of the first, second, and edge surfaces of the substrate,wherein the layer includes: (i) one of an oligomer and resin; (ii) a monomer; and (iii) nanometer-sized silica particles of at least about 2-50 weight percent.2. The apparatus of claim 1 , wherein the weight percentage of the nanometer-sized silica particles is one of: (i) between about 10-30 weight percent; (ii) between about 10-20 weight percent; (iii) between about 10-15 weight percent; and (iv) at least about 14 weight percent.3. The apparatus of claim 1 , wherein at least 70-90 percent of the nano-sized silica particles have diameters of one of: (i) between about 5-40 nm; (ii) between about 7-35 nm; (iii) between about 10-30 nm; (iv) between about 15-25 nm; (v) between about 17-23 nm; and (vi) about 20 nm.4. The apparatus of claim 1 , wherein the oligomer is a urethane acrylate of one of: (i) between about 40-60 weight percent; and (ii) about 50 weight percent.5. The apparatus of claim 1 , wherein the oligomer is an aliphatic urethane acrylate claim 1 , and the monomer is at least one of diethylacrylamide and cyclic trimethylolpropane formal acrylate.6. The apparatus of claim 1 , wherein the resin is an epoxy resin of one of: (i) between about 20-90 weight percent; (ii) between about 25-85 weight percent; ...

ANTIMICROBIAL MATERIALS INCLUDING EXCHANGED AND INFUSED ANTIMICROBIAL AGENTS

Embodiments of antimicrobial materials are provided. In one or more embodiments, the antimicrobial materials include an inorganic substrate including a surface portion surrounding an internal portion and an antimicrobial agent disposed on any one or more of the surface portion and the internal portion. In some embodiments, the inorganic substrate included alkali and at least a portion of the alkali is present on the surface portion. In another embodiment the antimicrobial agent is infused into the substrate. In some instances, non-alkali components present in the substrate are replaced with the antimicrobial agent. In some embodiments, anions in the substrate are replaced with the antimicrobial agent. Compositions including the antimicrobial materials are disclosed and methods for making the antimicrobial materials and compositions are also provided. 1. An antimicrobial material comprising:an inorganic substrate comprising alkali, the inorganic substrate comprising a surface portion surrounding an internal portion; andan antimicrobial agent disposed on any one or more of the surface portion and the internal portion,wherein at least a portion of the alkali is present on the surface portion.2. An antimicrobial material comprising:an inorganic substrate comprising a surface portion surrounding an internal portion; andan infused antimicrobial agent disposed on any one or more of the surface portion and the internal portion.3. The antimicrobial material of claim 2 , further comprising exchanged antimicrobial agents claim 2 , wherein the substrate comprises non-alkali components that are replaced with the antimicrobial agent.4. The antimicrobial material of claim 2 , wherein the inorganic substrate is substantially alkali-free.5. An antimicrobial material comprising:an inorganic substrate comprising anions and a surface portion surrounding an internal portion; andan antimicrobial agent disposed on any one or more of the surface portion and the internal portion,wherein at ...

Thermally stable and electrically isolating barrier film

A thermoset barrier film including: a reaction product of the formulas (I), (II), (III), (IV), or a mixture thereof, as defined herein. Also disclosed are methods of making and using the thermoset barrier film, and devices incorporating the thermoset barrier film.

STRENGTHENED GLASS, GLASS-CERAMIC AND CERAMIC ARTICLES AND METHODS OF MAKING THE SAME THROUGH PRESSURIZED ION EXCHANGE

A method of treating a substrate is provided that includes the steps: submersing a substrate having an outer region containing a plurality of divalent exchangeable ions in a bath that comprises a polar solvent and a plurality of divalent ion-exchanging ions, the substrate comprising a glass, glass-ceramic or ceramic; pressurizing the bath to a predetermined pressure substantially above ambient pressure; and heating the bath to a predetermined temperature above ambient temperature. The method also includes a step of treating the substrate for a predetermined ion-exchange duration such that a portion of the plurality of divalent exchangeable ions is exchanged with a portion of the divalent ion-exchanging ions. In addition, the step of treating the substrate results in a greater number of divalent ion-exchanging ions entering the substrate than divalent exchangeable ions exiting the substrate. 1. A method of treating a substrate , comprising the steps:submersing a substrate having an outer region containing a plurality of divalent exchangeable ions in a bath that comprises a polar solvent and a plurality of divalent ion-exchanging ions;pressurizing the bath to a predetermined pressure, wherein the predetermined pressure is substantially above ambient pressure;heating the bath to a predetermined temperature, wherein the predetermined temperature is above ambient temperature; andtreating the substrate for a predetermined ion-exchange duration at the predetermined pressure and temperature such that a portion of the plurality of divalent exchangeable ions is exchanged with a portion of the ion-exchanging ions, andwherein the substrate comprises a glass, glass-ceramic or ceramic.2. The method according to claim 1 , wherein the step for treating the substrate is further conducted to define a divalent ion-exchange region in the outer region that extends from a first surface to a first selected depth in the substrate.3. The method according to claim 1 , wherein the ...

ELECTRICALLY ISOLATING POLYMER COMPOSITION

An electrode coating composition that includes at least one crosslinkable monomer; at least one hydrophobic monomer; and at least one dielectric constant enhancing agent selected from dielectric enhancing monomers, ferroelectric particulates, and electroactive polymers. Coatings including the polymer of compositions, and articles including electrically isolating layers are also disclosed. 2. The coated electrode of wherein the coating has a thickness of from 10 nm to 1 mm.3. A coated electrode comprising:an electrode: anda polymerized and crosslinked thermoset product of: 'from 20 to 85 wt % of at least one hydrophobic monomer; and', 'from 5 to 30 wt % of at least one crosslinkable monomer;'}at least one dielectric constant enhancing agent in from 2 to 60 wt %, based on the total weight of the coating composition,wherein the at least one dielectric constant enhancing agent comprises a dielectric enhancing monomer in from 10 to 60 wt %, the coating has a dielectric constant of from 1.5 to 10 and has a breakdown voltage property of from 750 to 1,800 volts per micron.4. The coated electrode of wherein the dielectric enhancing monomer is selected from the group consisting of a furfuryl methacrylate claim 3 , a tris (2-hydroxyethyl) isocyanurate claim 3 , benzylmethacrylate claim 3 , 2-cyanoethylacrylate claim 3 , vinylferrocene claim 3 , a propargyl methacrylate claim 3 , and mixtures thereof.5. The coated electrode of wherein the at least one hydrophobic monomer is a fluorinated urethane hexacrylate comprised of a mixture of 5 to 20 wt % dihydroperfluoropentane having from 40 to 45 wt % acrylic esters and from 40 to 45 wt % urethane hexacrylate or a mixture thereof.6. The coated electrode of wherein the at least one hydrophobic monomer is cross-linked.7. The coated electrode of further comprising at least one optical component claim 3 , or a combination of one or more optical components.8. The coated electrode of further comprising at least one dielectric constant ...

UV-Curable Coatings

UV-curable coating compositions are provided including (in weight %) 5-50% cycloaliphatic crosslinker of the formula 2. The UV-curable coating composition of comprising 5.5-27.5% cycloaliphatic crosslinker claim 1 , 27.5-49.5% of a summed amount of oxetane crosslinker and epoxy diluent claim 1 , 39.9% epoxy functionalized silicon nanoparticles claim 1 , 3.1% epoxy silane adhesion promoter and 2% photoinitiator.3. The UV-curable coating composition of consisting of 5.5-27.5% cycloaliphatic crosslinker claim 1 , 27.5-49.5% of a summed amount of oxetane crosslinker and epoxy diluent claim 1 , 39.9% epoxy functionalized silicon nanoparticles claim 1 , 3.1% epoxy silane adhesion promoter and 2% photoinitiator.4. The UV-curable coating composition of comprising 5.5% cycloaliphatic crosslinker claim 1 , 24.75% oxetane crosslinker claim 1 , 24.75% epoxy diluent claim 1 , 39.9% epoxy functionalized silicon nanoparticles claim 1 , 3.1% epoxy silane adhesion promoter and 2% photoinitiator.5. The UV-curable coating composition of consisting of 5.5% cycloaliphatic crosslinker claim 1 , 24.75% oxetane crosslinker claim 1 , 24.75% epoxy diluent claim 1 , 39.9% epoxy functionalized silicon nanoparticles claim 1 , 3.1% epoxy silane adhesion promoter and 2% photoinitiator.6. The UV-curable coating composition of wherein the oxetane crosslinker is bis(1-ethyl-(3-oxetanyl)methyl)ether.7. The UV-curable coating composition of wherein the epoxy diluent is 3-ethyl-3-hydroxymethyl oxetane.8. The UV-curable coating composition of wherein the silicon nanoparticles of the epoxy functionalized silicon nanoparticles are in the range of 5-200 nm.9. The UV-curable coating composition of wherein the silane adhesion promoter is selected from an amino functional silane claim 1 , a ureido functional silane claim 1 , an epoxy functional silane claim 1 , a sulfur functional silane claim 1 , and mixtures thereof.10. The UV-curable coating composition of wherein the silane adhesion promoter is an amino ...

Swellable (meth)acrylate surfaces for culturing cells in chemically defined media

Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol) dimethacrylate. The conjugated peptide may include an amino acid sequence of Xaa n ProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.

Methods and apparatus providing a substrate and protective coating thereon

Methods and apparatus are provide for: a glass substrate having first and second opposing surfaces, and a plurality of edge surfaces extending transversely between the first and second opposing surfaces; a layer disposed on, and adhered to, at least one of the first, second, and edge surfaces of the substrate, where the layer includes: (i) one of an oligomer and resin; (ii) a monomer; and (iii) nanometer-sized silica particles of at least about 2 - 50 weight percent.

包含電絕緣層之電極塗層以及製品

本發明揭露了一種包含至少一種可交互連結單體、至少一種疏水性單體以及至少一種從介電增強單體、鐵電顆粒和電活性聚合物所組成之群組選出的介電常數增強劑之組成份。本發明亦揭露了包含聚合物組成份的塗層及包含電絕緣層的製品。

提供基板與其上之保護塗層的方法及設備

就以下而言提供方法及設備：一玻璃基板，其具有第一對向表面及第二對向表面，及在該第一對向表面與該第二對向表面之間橫向延伸的複數個邊緣表面；一層，其安置於該基板之該等第一表面、第二表面及邊緣表面中之至少一者上，或黏著於該等表面中之至少一者，其中該層包括：(i)一寡聚物及樹脂中之一者；(ii)一單體；及(iii)至少約2-50重量百分比之奈米大小的矽石粒子。

Thermally stable and electrically isolating barrier film

A thermoset barrier film including: a reaction product comprising an anhydride-capped fluorinated polyimide oligomer, a POSS-crosslinker having an epoxy, di-aryl or acrylat group, a tie-agent having an acrylate and an epoxy group, an epoxy silane adhesion promoter and an initiator; and being represented by one of the formulas (I), (II), (III), (IV), or a mixture thereof, as defined herein. Also disclosed are methods of making and using the thermoset barrier film, and devices incorporating the thermoset barrier film.

Uv-curable coating compositions for glass based on epoxy/oxetane compounds, epoxy functionalized silsesquioxane and epoxy functionalized nanoparticles.

UV-curable coating compositions are provided including (in weight %) 5-50% cycloaliphatic crosslinker of the formula wherein R is wherein X is a C1-4 straight chain, 20-55% of a summed amount of an oxetane crosslinker and an epoxy diluent, 35-45% epoxy functionalized silicon nanoparticles, 1-5% epoxy silane adhesion promoter and 0.5-2% photoinitiator.

Thermally stable and electrically isolating barrier film

A thermoset barrier film including: a reaction product comprising an anhydride-capped fluorinated polyimide oligomer, a POSS-crosslinker having an epoxy, di-aryl or acrylat group, a tie-agent having an acrylate and an epoxy group, an epoxy silane adhesion promoter and an initiator; and being represented by one of the formulas (I), (II), (III), (IV), or a mixture thereof, as defined herein. Also disclosed are methods of making and using the thermoset barrier film, and devices incorporating the thermoset barrier film.

Improved mechanized apparatus for the cutting and collecting of standing sugar cane

Polymerizable catonic peptide monomers and polymers

Disclosed herein are functionalized cationic peptide monomers: peptide chains of two or more positively charged amino acids chosen from lysine or arginine, or derivatives thereof, which are functionalized, meaning that they are bound to one or more polymerization moieties. The functionalized cationic peptide monomers can be described by the formula Z-Xaa n -Z 1 n1 wherein Z and Z 1 are polymerization moieties and n1 is an integer of 0 or 1; Xaa is each independently an amino acid Lys or Arg and n is an integer from 2 to 10 and wherein at least one Xaa amino acid of Xaa is Lys, wherein the carboxyl terminus of the amino acid sequence is amidated. Functionalized cationic peptide monomers can be combined and polymerized to form cell culture surfaces.

Improved mechanized apparatus for the cutting and collecting of standing sugar cane

Electrically isolating polymer composition

An electrode coating composition that includes at least one crosslinkable monomer; at least one hydrophobic monomer; and at least one dielectric constant enhancing agent selected from dielectric enhancing monomers, ferroelectric particulates, and electroactive polymers. Coatings including the polymer of compositions, and articles including electrically isolating layers are also disclosed.