16-06-2016 дата публикации
Номер: US20160168151A1
Принадлежит:
This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof. 2. A compound according to claim 1 , wherein Ris benzyl optionally substituted with mono claim 1 , di or tri —OH.3. A compound according to claim 1 , wherein Ris phenyl optionally substituted with mono claim 1 , di or tri-OH.4. (canceled)5. (canceled)6. A compound according to claim 1 , wherein Ris C-Calkyl.7. A compound according to claim 1 , wherein Z is NRR; and Rand Rare H.8. A compound according to claim 1 , wherein Ris C-Calkyl optionally substituted with alkoxy.9. A compound according to claim 1 , wherein Ris H and Ris methyl.10. A compound according to claim 1 , wherein claim 1 , Ris phenyl optionally substituted with —CH.11. A compound according to claim 1 , wherein Ris phenyl substituted with —NH.1214.-. (canceled)17. (canceled)1819.-. (canceled)20. A pharmaceutical composition claim 1 , comprising:a pharmaceutically acceptable carrier; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a compound or pharmaceutically-acceptable salt according to .'}2144.-. (canceled) This application is a continuation of U.S. application Ser. No. 14/738,169 filed Jun. 12, 2015, which is a continuation of U.S. application Ser. No. 14/523,581 filed Oct. 24, 2014, which is a continuation of U.S. application Ser. No. 14/186,486 filed Feb. 21, 2014, which is a continuation of U.S. application Ser. No. 13/862,348 filed Apr. 12, 2013, which is a continuation of U.S. application Ser. No. 13/016,957 filed Jan. 28, 2011, which is a continuation of U.S. application Ser. No. 12/194,469 filed Aug. ...
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