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Применить Всего найдено 3. Отображено 3.
14-09-2017 дата публикации

NOVEL OXIMES FOR REACTIVATING BUTYRYLCHOLINESTERASE

Номер: US20170258774A1
Автор: Janice E. Chambers, Howard W. Chambers, Edward C. Meek, CHAMBERS JANICE E, CHAMBERS HOWARD W, MEEK EDWARD C, Chambers Janice E., Chambers Howard W., Meek Edward C.
Принадлежит: MISSISSIPPI STATE UNIVERSITY

Oxime molecules for reactivating butyrylcholinesterase (BChE) and methods for protection against and therapeutic treatment of the toxic effects of organophosphorus compounds (OP) cholinesterase inhibitors such as nerve agents and/or insecticides are provided. The oxime molecules can be administered to a subject in need thereof to treat or prevent toxic effects of OPs. The oxime molecules can allow for a dual reactivation treatment paradigm by reactivating both serum BChE and inactivated CNS AChE. 1. A method of treating the effects of exposure to an organophosphorus compound in a subject in need thereof comprising administering an effective amount of a therapeutic composition comprising one or more phenoxyalkyl pyridinium oxime molecules and at least one pharmaceutical carrier to the subject , and reactivating serum butyrylcholinesterase in the subject.3. The method of claim 2 , wherein the one or more phenoxyalkyl pyridinium oxime molecules are selected from the group consisting of{'sub': '3', '(a) n=5 and R=4-CH—O—;'}(b) n=4 and R=4-Cl—;{'sub': 3', '2, '(c) n=4 and R=4-CHCHC(:O)—;'}(d) n=3 and R=3-CH═CHCH═CH-4;{'sub': '2', '(e) n=4 and R=4-Ph—CH—O—;'}{'sub': 3', '3', '2', '3', '2, '(f) n=4 and R=4-(CH)CCHC(CH)—; and'}{'sub': 3', '3', '2', '3', '2, '(g) n=5 and R=4-(CH)CCHC(CH)—.'}4. The method of claim 2 , wherein the one or more phenoxyalkyl pyridinium oxime molecules are selected from the group consisting of (1) n=4 and R=4-l—and (2) n=4 and R=4-Ph—CH—O—.5. The method of further comprising reactivating acetylcholinesterase in the subject.6. The method of claim 1 , wherein the reactivation of the serum butyrylcholinesterase is continual during exposure to the one or more phenoxyalkyl pyridinium oxime molecules such that the serum butyrylcholinesterase in the presence of the one or more phenoxyalkyl pyridinium oxime molecules acts as a pseudo-catalytic destruction mechanism of the organophosphorus compound.7. The method of claim 1 , wherein the administering step ...

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Номер записи: 1
04-07-2013 дата публикации

PHENOXYALKYL PYRIDINIUM OXIME THERAPEUTICS FOR TREATMENT OF ORGANOPHOSPHATE POISONING

Номер: US20130172393A1
Автор: Chambers Howard W., Chambers Janice E., Meek Edward C.
Принадлежит:

Phenoxyalkyl pyridinium oxime compounds for use in treating organophosphate poisoning. 2. The composition of claim 1 , wherein R is methyl claim 1 , ethyl claim 1 , phenyl claim 1 , methoxy claim 1 , ethoxy claim 1 , trimethyl claim 1 , methylchloro claim 1 , diethyl claim 1 , diethylchloro claim 1 , ethylchloro claim 1 , phenoxy claim 1 , acetyl claim 1 , benzoyl claim 1 , bromo claim 1 , chloro claim 1 , iodo claim 1 , dichloro claim 1 , or trichloro.3. The composition of claim 1 , wherein R is one of the following substituents:{'sub': '3', '4-CH—;'}{'sub': 3', '2', '2, '2,6-([CH]CH)—;'}{'sub': '3', '4-CH—O;'}4-Cl—;4-Br—;{'sub': '2', '4-ON—;'}{'sub': '2', '3-ON—;'}{'sub': '3', '4-CHCO—;'}{'sub': 3', '2, '4-CHCHCO—;'}3-CHCH═CHCH-4;4-Ph;{'sub': 3', '3, '2,3,5-(CH)—;'}{'sub': 3', '3, '2,4,6-(CH)—;'}{'sub': '3', '3-CH-4-Cl—;'}4-Ph-CO—;{'sub': '2', '2,5-Cl—;'}4-Ph-O—;{'sub': '2', '4-Ph-CH—;'}{'sub': '2', '4,Ph-CH—O—;'}{'sub': '3', '2,4,5-Cl)—;'}{'sub': '2', '4-Ph-CHCO—;'}{'sub': '3', '2,4,6-Cl—;'}{'sub': '2', '3,4-Cl—;'}{'sub': 2', '2, '2,6-Cl-4-ON—;'}{'sub': 3', '2, '4-Cl-3,5-(CH)—;'}3-Ph-;{'sub': 3', '2, '3-CHCH-4-Cl—;'}{'sub': '3', '3-O—C(:O)—CH═C(CH)-4;'}{'sub': 3', '3', '3, '2-CH-4-(CH)C—;'}{'sub': 3', '3', '2, '2,4-[(CH)C—]—;'}{'sub': 3', '2', '3', '2, '4-CHCHC(CH)—;'}{'sub': 3', '3', '2', '2', '2, '4-(CH)CCHC(CH)—;'}2-Br-4-Cl—;2-Cl-4-Br—;{'sub': '3', '2-Br-4-CH—;'}{'sub': 3', '2, '4-Br-3,5-(CH)—;'}{'sub': 3', '2', '6, '4-CH(CH)—O—;'}{'sub': 3', '2, '4-Ph-C(CH)—;'}{'sub': 3', '2', '2, '4-CH—O—CHCH—; or'}{'sub': '2', '2,4-Cl—.'}43. The composition of any of - claims 1 , wherein X is halo claims 1 , optionally bromo.54. The composition of any of - claims 1 , wherein the composition comprises a pharmaceutically acceptable excipient in combination with the compound.65. A method of reactivating phosphorylated brain acetylcholinesterase that has been inhibited by at least one organophosphorous compound claims 1 , the method comprising administering to a subject in need ...

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Номер записи: 2
17-11-2011 дата публикации

Phenoxyalkyl pyridinium oxime therapeutics for treatment of organophosphate poisoning

Номер: WO2011142826A1
Автор: Edward C. Meek, Howard W. Chambers, Janice E. Chambers
Принадлежит: Mississipi State University

Phenoxyalkyl pyridinium oxime compounds for use in treating organophosphate poisoning.

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Номер записи: 3