Fluid-assisted electrocautery device

An electrocautery instrument is provided with a hollow electrode having a source of conductive fluid coupled to a proximal end thereof. Conductive fluid is communicated through said electrode and expelled out of the distal end thereof during electrocautery, forming a “virtual electrode.” The infused conductive liquid conducts the RF electrocautery energy away from the conductive electrode, thereby displacing the region of thermal generation and reducing the extent of burns and perforations caused by conventional electrocautery electrodes. In one embodiment, the electrode is partially disposed within and extends distally out of a retractable suction tube, such that smoke and fluid are aspirated from the electrocautery site. When the suction tube is fully advanced, the electrode is concealed therein, enabling suction without electrocautery to be performed.

Medical probes for the treatment of blood vessels

Devices and methods for thermally-mediated treatment of blood vessels to elicit an immune response to cause rapid endothelial growth over at least portions of an implant or stent to prevent adverse events such as restenosis. Devices and methods for thermally-mediated treatment to inhibit contraction of vessels to elicit an immune response to cause rapid endothelial growth over at least portions of a stent to prevent adverse events such as restenosis.

Electrode stimulation applicator patch

Organoclay compositions prepared from ester quats and composites based on the compositions

Medical system and method of use

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.

Lubricant composition comprising hindered cyclic amines

A lubricant composition includes a base oil and a cyclic amine compound. A method of lubricating a system including a fluoropolymer seal with the lubricant composition is also provided. An additive concentrate for a lubricant composition is also provided. The cyclic amine compound is useful for adjusting the total base number of a lubricant composition. The lubricant composition is compatible with fluoropolymer seals.

Systems and Methods for Treatment of Prostatic Tissue

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Methods associated with use of the prostate therapy system are also covered. 1. A prostate ablation system , comprising:a vapor generator; anda vapor delivery probe operatively coupled to the vapor generator and adapted to be inserted transurethrally into a prostate adjacent to a prostatic urethra of a patient, the vapor delivery probe adapted to deliver condensable vapor from the vapor generator into the prostate to deliver between 100 and 10,000 Joules to the prostate to ablate the prostate without ablating the prostatic urethra.2. The system of wherein the vapor generator is disposed within the vapor delivery probe.3. The system of wherein the vapor generator is disposed within a handle of the vapor delivery probe.4. The system of wherein the vapor delivery probe further comprises a vapor needle configured to be advanced through the prostatic urethra into the prostate.5. The system of wherein the vapor needle comprises a plurality of vapor ports configured to deliver condensable vapor to the prostate.6. The system of wherein the vapor needle is coupled to an actuation mechanism configured to advance the vapor needle through the prostatic urethra into the prostate.7. The system of wherein the actuation mechanism is configured to advance the vapor needle into an apex of the prostate.8. The system of wherein the actuation mechanism is configured to advance the vapor needle at least 15 mm into the prostate.9. The system of wherein the actuation mechanism is manually controlled.10. The system of wherein the manually controlled actuation mechanism comprises a spring-loaded mechanism.11. The system of further comprising a lever on a handle of the vapor ...

Tuned RF energy for selective treatment of atheroma and other target tissues and/or structures

A catheter and catheter system can use energy tailored for remodeling and/or removal of target material along a body lumen, often of atherosclerotic material of a blood vessel of a patient. An elongate flexible catheter body with a radially expandable structure may have a plurality of electrodes or other electrosurgical energy delivery surfaces to radially engage atherosclerotic material when the structure expands. An atherosclerotic material detector system may measure and/or characterize the atherosclerotic material and its location, optionally using impedance monitoring.

Systems and Methods for Treatment of Prostatic Tissue

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered. 1. A method of treating a disorder of a prostate comprising:introducing an ablation probe transurethrally into the prostate, the ablation probe having a longitudinal axis;injecting a condensable vapor through the ablation probe into the prostate; andtranslating the ablation probe along its longitudinal axis while injecting the condensable vapor into the prostate.2. The method of further comprising inserting an introducer into a urethra and advancing the ablation probe through the introducer.3. The method of wherein the introducing step comprises advancing the ablation probe into an apex of a lobe of the prostate.4. The method of further comprising aspirating prostate tissue proximally through the ablation probe to remove a core of prostate tissue.5. The method of further comprising rotating the ablation probe around its longitudinal axis while injecting the condensable vapor into the prostate.6. The method of wherein injecting the condensable vapor comprises delivering between 100 W and 1000 W to the prostate.7. The method of wherein injecting the condensable vapor comprises delivering between 250 cal/gram and 450 cal/gram to the prostate.8. The method of wherein aspirating prostate tissue further comprises removing between 10 grams and 50 grams of prostate tissue from the prostate.9. The method of wherein aspirating prostate tissue comprises removing prostate ...

Systems and methods for prostate treatment

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the needle can ablate a continuous lobe region in the prostate parallel to the urethral wall. Another feature of the vapor delivery needle is that it can introduce a cooling fluid into the urethra during treatment. Methods associated with use of the energy delivery probe are also covered.

Seal compatibility additive to improve fluoropolymer seal compatibility of lubricant compositions

This disclosure is directed to an additive package for a lubricant composition that provides improved compatibility with fluoropolymer seals. The additive package comprises a seal compatibility additive. The disclosure is also directed to a lubricant composition comprising a base oil and a seal compatibility additive. The seal compatibility additive improves the compatibility with fluoropolymer seals of the resultant lubricant composition.

SYSTEMS AND METHODS FOR PROSTATE TREATMENT

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the needle can ablate a continuous lobe region in the prostate parallel to the urethral wall. Another feature of the vapor delivery needle is that it can introduce a cooling fluid into the urethra during treatment. Methods associated with use of the energy delivery probe are also covered. 1. A vapor therapy system , comprising:a shaft adapted to be inserted into a male urethra;a vapor delivery needle in the shaft, the needle comprising a vapor exit port;a vapor needle deployment mechanism adapted to move a tip of the needle generally transverse to the shaft, wherein the vapor needle deployment mechanism cannot move the vapor delivery needle more than 15 mm from the shaft;a vapor source; anda vapor delivery actuator adapted to deliver vapor from the vapor source into the vapor delivery needle and out of the vapor exit port.2. The system of wherein the vapor delivery needle is movable between a retracted position in which a distal needle tip is within the shaft and a deployed position in which the distal needle tip extends from the shaft.3. The system of further comprising a needle-retraction actuator adapted to retract the vapor delivery needle into the shaft.4. The system of wherein the vapor delivery needle comprises a non-energy applicator portion that does not include a vapor exit port.5. The system of wherein the non-energy applicator portion is approximately the thickness of the male urethra.6. The system of wherein the vapor delivery needle comprises a flexible polymer tube with sharp tip.7. The system of further comprising an irrigation liquid source and an irrigation passage in the shaft extending from the irrigation liquid source to an irrigation liquid outlet.8. The system of further comprising ...

Seal Compatibility Additive To Improve Fluoropolymer Seal Compatibility of Lubricant Compositions

This disclosure is directed to an additive package for a lubricant composition that provides improved compatibility with fluoropolymer seals. The additive package comprises a seal compatibility additive. The disclosure is also directed to a lubricant composition comprising a base oil and a seal compatibility additive. The seal compatibility additive improves the compatibility with fluoropolymer seals of the resultant lubricant composition. 1. An additive package for a lubricant composition that provides improved compatibility with fluoropolymer seals , said additive package comprising: at least one halogen atom selected from the group consisting of fluorine, bromine, iodine, and combinations thereof, and', 'wherein said at least one halogen atom is bonded to said at least one carbon atom in said acyclic hydrocarbon backbone; and', 'an acyclic hydrocarbon backbone comprising at least one carbon atom,'}], 'a seal compatibility additive comprisingan amine compound.3. The additive package of wherein X is bromine.4. The additive package of wherein X is iodine.5. The additive package of wherein said amine compound comprises a sterically hindered amine compound.7. The additive package of wherein said amine compound comprises an amine dispersant.8. The additive package of further comprising an anti-wear agent comprising phosphorous.9. A lubricant composition that provides improved compatibility with fluoropolymer seals claim 1 , said lubricant composition comprising:a base oil; at least one halogen atom selected from the group consisting of fluorine, bromine, iodine, and combinations thereof, and', 'wherein said at least one halogen atom is bonded to said at least one carbon atom in said acyclic hydrocarbon backbone; and', 'an acyclic hydrocarbon backbone comprising at least one carbon atom,'}], 'a seal compatibility additive comprisingan amine compound.11. The lubricant composition of wherein X is bromine.12. The lubricant composition of wherein X is iodine.13. The ...

Medical system and method of use

Methods, systems and devices for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure.

VAPOR ABLATION SYSTEMS AND METHODS

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the vapor delivery needle can be advanced a predetermined distance into the prostate with a solenoid actuation mechanism. Methods associated with use of the energy delivery probe are also covered.

Method Of Forming Additive Packages and Lubricant Compositions That Include A Seal Compatibility Additive

This disclosure is directed to a method of forming an additive package for a lubricant composition. The method includes the step of providing a base oil and a dispersant, the step of heating the base oil and the dispersant, and the step of combining the base oil and the dispersant to form a first mixture. The method further includes the step of providing a detergent, the step of heating the detergent, and the step of combining the first mixture and the detergent to form a second mixture. The method further includes the step of providing an anti-wear additive and a seal compatibility additive, the step of heating the anti-wear additive the seal compatibility additive, and the step of combining the second mixture, the anti-wear additive, and the seal compatibility additive to form the additive package. 1. A method of forming an additive package for a lubricant composition , said method comprising the steps of:providing a base oil and a dispersant;heating the base oil and the dispersant to a temperature of from 75 to 115° C.;combining the base oil and the dispersant to form a first mixture;providing a detergent;heating the detergent to a temperature of from 50 to 90° C.;combining the first mixture and the detergent to form a second mixture;providing an antioxidant, an anti-wear additive, and a seal compatibility additive;heating the antioxidant, the anti-wear additive, and the seal compatibility additive to a temperature of from 30 to 70° C.; andcombining the second mixture, the antioxidant, the anti-wear additive, and the seal compatibility additive to form the additive package.2. The method of claim 1 , wherein the seal compatibility additive comprises an epoxide compound claim 1 , a boroxine compound claim 1 , a sulfonate ester claim 1 , a halogen compound claim 1 , or combinations thereof.3. The method of claim 1 , wherein the dispersant comprises an amine dispersant.4. The method of claim 1 , wherein the anti-wear additive comprises a dihydrocarbyl dithiophosphate ...

Device and method for ablating tissue

An electrosurgery medical device is enhanced with unique solution-assistance, and comprises, in combination, co-operating device jaws including jaw portions for manipulating tissue, and a plurality of solution infusion openings defined and spaced along each of the jaw portions, for receiving electrolytic solution and infusing the solution onto and into tissue to be manipulated, along said jaw portions. As preferred, the device further comprises at least one, and most preferably, many, longitudinal groove(s) along at least one and most preferably, both, of the jaw portions, with the solution infusion openings located in the groove or grooves. The solution is energized with RF energy and contributes to the functions and beneficial effects of the instrument. The solution exits the openings in the grooves at sufficient flow rates to separate substantially all the operative surfaces of the device from tissue, thereby substantially completely preventing adherence between the operative surfaces ...

Medical instruments and techniques for treating pulmonary disorders

A surgical instrument for delivering energy to lung tissue, for example to cause lung volume reduction. In one embodiment, an elongated catheter has a handle portion that includes an interior chamber that is supplied with a biocompatible liquid media under pressure. An energy source delivers energy to the media to cause a liquid-to-vapor phase change within the interior chamber and ejects a flow of vapor media from the working end of the catheter. The delivery of energy and the flow of vapor are controlled by a computer controller to cause a selected pressure and selected volume of vapor to propagate to the extremities of the airways. Contemporaneously, the vapor undergoes a vapor-to-liquid phase transition which delivers a large amount of energy to airway tissue. The thermal energy delivered is equivalent to the heat of vaporization of the fluid media, which shrinks and collapses the treated airways. The treated tissue is the maintained in a collapsed state by means of aspiration for a ...

Variable length electrodes for delivery of irrigated ablation

A device for ablating tissue is provided. The device comprises a conductive element with a channel for irrigating fluid formed therein, which is in contact with a non-conductive microporous interface. All or a portion of the interface may be removable. When the interface is removed, a portion of the conductive element is exposed for use in ablating tissue. Methods of using the device and of removing the interface are also provided.

Systems and methods for treatment of BPH

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe from the urethra. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered.

Tissue Discrimination and Applications in Medical Procedures

A system and method for discriminating tissue types, controlling the level of therapy to tissue, and determining the health of a known tissue by measuring the characteristics of an electrical signal applied to a conductive element located within or by the tissue. Additionally, the system and method may be used for determining whether the conductive tip of a pedicle probe or pedicle screw is located in one of cortical bone, cancellous bone, and cortical bone near a boundary with soft tissue, whether the conductive tip of a cannula is located adjacent to one of nerve tissue and annulus tissue, and whether the conductive tip of a cathode is located adjacent to one of nerve tissue and prostate gland tissue.

Lubricating Oil Compositions Containing A Halide Seal Compatibility Additive And A Second Seal Compatibility Additive

This disclosure is directed to an additive package for a lubricant composition that provides improved fluoropolymer compatibility. The additive package comprises a halide seal compatibility additive and a second seal compatibility additive. The disclosure is also directed to a lubricant composition comprising a base oil, a halide seal compatibility additive, and a second seal compatibility additive. The halide seal compatibility and the second seal compatibility additive improves the fluoropolymer seal compatibility of the resultant lubricant composition.

Methods for delivering energy into a target tissue of a body

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.

Systems and methods for treatment of prostatic tissue

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Methods associated with use of the prostate therapy system are also covered.

Alkoxylated amides, esters, and anti-wear agents in lubricant compositions and racing oil compositions

A lubricant composition includes a base oil, an alkoxylated amide, an ester, and an anti-wear agent including phosphorus. The alkoxylated amide and ester have general formulas (I) and (II), respectively. The lubricant composition may be further defined as a racing oil composition. Also disclosed is a method for maximizing the effectiveness of a friction modifier in a racing oil composition thus increasing the fuel economy of a racing vehicle. The method includes providing the racing oil composition and lubricating an internal combustion engine of a racing vehicle to increase the fuel economy of the racing vehicle.

Medical system and method of use

An instrument and method for applying thermal energy to targeted tissue. An instrument and method for tissue thermotherapy. In one embodiment, a method includes providing a vapor source comprising a pump configured for providing a flow of liquid media from a liquid media source into a vaporization chamber having a heating mechanism, actuating the pump to provide the liquid into the vaporization chamber, applying energy from the heating mechanism to convert a substantially water liquid media into a minimum water vapor level for causing an intended effect in tissue. For examples such levels can comprise at least 60% water vapor, at least 70% water vapor, at least 80% water vapor or at least 90% water vapor for causing an intended effect in tissue.

SYSTEM AND METHOD OF SUB CLINICAL DETECTING MASTITIS

Mastitis in a milking animal is detected through sensing the capacitance effects in milk. Using frequencies of greater than 60 megahertz applied by a capacitance probe to milk as it streams through otherwise conventional milking equipment during milking, yields a reliably discernable shift in the phase angle, indicating the presence of mastitis. 1. A milking apparatus , comprising:a) a milking claw having teat cups, each teat cup in fluid communication with a cup conduit;b) claw conduit in fluid communication with said cup conduits;c) multiple electrical probes positioned to contact milk as it flows through the apparatus during milking, with one probe per teat;d) generator circuits for supplying AC current to each of said probes at a frequency of greater than 60 megahertz;e) phase monitoring circuits for measuring the shift in the phase angle of the signal while AC current is applied to said probe that results from the presence of the milk in each probe;f) comparison circuits for comparing the phase angle measurement of any one probe with complementary companion probes.2. A milking apparatus according to claim 1 , wherein said probe comprises two spaced-apart electrodes exposed directly to milk.3. A milking apparatus according to claim 2 , wherein said electrodes are cylindrical and parallel to each other.4. A method of detecting disease in a milk cow claim 2 , comprising:a) positioning an electrical probe within milk to be tested;b) delivering current to said probe at a frequency of greater than 60 megahertz;c) measuring the phase angle of the signal while AC current is applied to said electrodes;d) comparing the measured phase angle from the circuit electrically upstream of the milk to that measured by the probe in the milk.5. A method according to claim 4 , wherein said frequency is greater than 65 megahertz.6. A method according to claim 4 , wherein said step of delivering current is conducted during milking of a cow. The present application is the Utility ...

System and method of detecting disease in mammal

Mastitis in a milking animal is detected through sensing the capacitance effects in milk. Using frequencies of greater than 60 megahertz applied by a capacitance probe to milk as it streams through otherwise conventional milking equipment during milking, yields a reliably discernable shift in the phase angle, indicating the presence of mastitis.

Systems and methods for treating the bladder with condensable vapor

A vapor delivery system and method is provided that is adapted for ablating bladder tissue to treat overactive bladder (OAB). The vapor delivery system includes an anchor tip configured anchor the system in the bladder while condensable vapor is delivered to target tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the target tissue of the bladder, which can include a surface sensor of the bladder responsible for creating an urge incontinence sensation. The vapor delivery system includes a vapor source that provides a high quality vapor for delivery to tissue.

Transperineal vapor ablation systems and methods

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, or denature tissues of the prostate. Methods associated with use of the energy delivery probe are also covered.

Systems and methods for treating the bladder with condensable vapor

A vapor delivery system and method is provided that is adapted for ablating bladder tissue to treat overactive bladder (OAB). The vapor delivery system includes an anchor tip configured anchor the system in the bladder while condensable vapor is delivered to target tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the target tissue of the bladder, which can include a surface sensor of the bladder responsible for creating an urge incontinence sensation. The vapor delivery system includes a vapor source that provides a high quality vapor for delivery to tissue.

LUBRICANT COMPOSITION COMPRISING HINDERED CYCLIC AMINES

A lubricant composition includes a base oil and a cyclic amine compound. A method of lubricating a system including a fluoropolymer seal with the lubricant composition is also provided. An additive concentrate for a lubricant composition is also provided. The cyclic amine compound is useful for adjusting the total base number of a lubricant composition. The lubricant composition is compatible with fluoropolymer seals. 2. A lubricant composition according to where said cyclic amine compound is present in an amount ranging from 0.1 to 10 wt. % claim 1 , based on a total weight of said lubricant composition.3. A lubricant composition according to where said cyclic amine compound has a weight average molecular weight ranging from 100 to 1200.4. A lubricant composition according to comprising said cyclic amine compound of said formula (I).5. A lubricant composition according to comprising said cyclic amine compound of said formula (II).6. A lubricant composition according to where each Ris an independently selected alkyl group having from 1 to 6 carbon atoms in each formula claim 1 , where Ris an alkyl group having from 7 to 17 carbon atoms claim 1 , where Ris an alkyl group having from 1 to 4 carbon atoms claim 1 , and where Ris an alkyl group having from 6 to 14 carbon atoms.7. A lubricant composition according to where said cyclic amine compound of said formula (I) comprises only one ester group.8. A lubricant composition according to where said cyclic amine compound has a TBN value of at least 70 mg KOH per g of said cyclic amine compound when tested according to ASTM D4739.9. A lubricant composition according to comprising less than 0.1 wt. % of compounds which would react with said cyclic amine compound based on the total weight of said lubricant composition.10. A lubricant composition according to where said base oil is selected from an API Group I Oil claim 1 , an API Group II Oil claim 1 , an API Group III Oil claim 1 , an API Group IV Oil claim 1 , and ...

Sulfonate Esters To Improve Fluoropolymer Seal Compatibility Of Lubricant Compositions

This disclosure is directed to a lubricant composition having improved compatibility with fluoropolymer seals. The lubricant composition includes a base oil and a sulfonate ester. The disclosure is also directed to an additive package for a lubricant composition that provides improved compatibility with fluoropolymer seals. The additive package includes the sulfonate ester. The disclosure is also directed to a method of improving compatibility of a lubricant composition with a fluoropolymer seal disposed in an internal combustion engine. The sulfonate ester improves the compatibility with fluoropolymer seals of the resultant lubricant composition. 2. The lubricant composition of wherein Rand Rare each independently an alkyl group claim 1 , an aryl group claim 1 , or a combination thereof claim 1 , with Rand Reach independently having from 1 to 17 carbon atoms.3. The lubricant composition of wherein Ris a methyl group and Ris an alkyl group having from 1 to 17 carbon atoms.4. The lubricant composition of wherein Ris an alkyl group having from 1 to 17 carbon atoms and Ris a 3 claim 2 ,5 claim 2 ,5-trimethylhexyl group.5. The lubricant composition of wherein Ris a methylbenzyl group and Ris a hydrocarbyl group having from 1 to 17 carbon atoms.6. The lubricant composition of wherein said sulfonate ester is further defined as a bis(sulfonate ester).7. The lubricant composition of wherein said sulfonate ester contributes less than 5 mg KOH/g to a total base number of said lubricant composition when tested according to ASTM D4739.8. The lubricant composition of wherein said sulfonate ester contributes less than 0.35 wt. % sulfated ash to said lubricant composition when tested according to ASTM D874.9. The lubricant composition of wherein said sulfonate ester is present in an amount of from 0.1 to 5 wt. % based on the total weight of said lubricant composition.10. The lubricant composition of further comprising an amine compound having a total base number of at least 80 mg ...

Lubricant Composition

Lubricant compositions comprising a base oil, one or more antioxidants selected from a group consisting of N-α-naphthyl-N-phenylamine antioxidants and diphenylamine antioxidants; and a sulfur-containing additive comprising up to seven carbon atoms exhibit outstanding oxidative stability and non-corrosion properties. The N-α-naphthyl-N-phenylamine antioxidants plus diphenylamine antioxidants in total may be present from about 0.2 wt % to about 0.8 wt %, based on the total weight of the lubricant composition. The sulfur provided by the sulfur-containing additive may be present from about 50 ppm to about 1000 ppm by weight, based on the total weight of the lubricant composition. 1. A lubricant composition comprisinga base oil,one or more antioxidants selected from a group consisting of N-α-naphthyl-N-phenylamine antioxidants and diphenylamine antioxidants; anda sulfur-containing additive comprising up to 7 carbon atoms.2. The lubricant composition according to claim 1 , wherein the N-α-naphthyl-N-phenylamine antioxidants plus diphenylamine antioxidants in total are present from about 0.2 wt % to about 0.8 wt % claim 1 , based on the total weight of the lubricant composition.3. The lubricant composition according to claim 1 , wherein a total sulfur concentration provided by the sulfur-containing additive ranges from about 50 ppm to about 1000 ppm by weight claim 1 , based on the total weight of the lubricant composition.5. The lubricant composition according to claim 1 , further comprising at least one additional sulfur-containing additive selected from a group consisting of sulfur-containing hindered phenolic compounds claim 1 , sulfur-containing rust inhibitors claim 1 , sulfur-containing friction modifiers and sulfur-containing antiwear additives.6. The lubricant composition according to claim 1 , wherein the sulfur-containing additive is a sulfurized isobutylene.7. The lubricant composition according to claim 6 , wherein the sulfurized isobutylene comprises a ...

High pressure and high temperature vapor catheters and systems

Devices and systems are described for treating intraluminal locations such as in a patient's lung. The device has an elongated shaft with an inner lumen, preferably defined by an inner tubular member, formed of heat resistant polymeric materials such as polyimide. The device also has an outer surface formed of heat resistant material. High temperature vapor is directed through the inner lumen into the intraluminal location to treat tissue at and distal to the location. An enlarged or enlargeable member, such as a balloon, is provided on a distal portion of the shaft to prevent proximal flow of the high temperature vapor upon discharge from the device.

High Pressure and High Temperature Vapor Catheters and Systems

Devices and systems are described for treating intraluminal locations such as in a patient's lung. The device has an elongated shaft with an inner lumen, preferably defined by an inner tubular member, formed of heat resistant polymeric materials such as polyimide. The device also has an outer surface formed of heat resistant material. High temperature vapor is directed through the inner lumen into the intraluminal location to treat tissue at and distal to the location. An enlarged or enlargeable member, such as a balloon, is provided on a distal portion of the shaft to prevent proximal flow of the high temperature vapor upon discharge from the device.

Pen-type electrosurgical instrument

An electrocautery device is disclosed. In accordance with one aspect of the invention, the electrocautery electrode/tip is provided with a hollow, conductive tube terminating at its distal end in a ball point type tip. Fluid, preferably conductive fluid, is applied to the proximal end of the hollow electrode/tip, and expelled from the distal end thereof during electrocautery. The ball point distal tip allows the distal tip to be directly applied to the tissue and “rolled” or slid along the tissue. This allows the distal tip to be moved across the tissue without dragging or snagging on the tissue. In addition, the conductive fluid expelled from the distal tip further lubricates the distal tip as it moves across the tissue. If conductive fluid is used, the conductive fluid emanating from the electrode/tip conducts the RF electrocautery energy away from the distal tip so that it is primarily the fluid, rather than the distal tip that actually accomplishes the cauterizing of tissue. That is ...

Lubricant composition having improved antiwear properties

The instant invention provides a lubricant composition having improved four-ball antiwear properties. The lubricant composition includes a base oil and one or more alkylethercarboxylic acid corrosion inhibitor(s) having the formula: wherein R is a straight or branched chain C6-C18 alkyl group and n is a number of from 0 to 5. The lubricant composition also includes an ashless antiwear additive including phosphorous. The four-ball antiwear properties are reported as an average diameter of wear scars pursuant to ASTM D4172. The average diameter of the wear scars resulting from the lubricant composition are at least 5% smaller than the average diameter of the wear scars resulting from a standard that includes the base oil and the antiwear additive and that is free of the one or more alkylethercarboxylic acid corrosion inhibitor(s).

Intravascular temperature sensor

Devices and methods for detecting vulnerable plaque within a blood vessel are disclosed. A catheter in accordance with the present invention includes an elongate shaft having a proximal end, a distal end, and an outer surface. At least one temperature sensor is disposed proximate to the distal end of the elongate shaft. In one preferred embodiment, the at least one temperature sensor is adapted to contact inner surface of the blood vessel. In another preferred embodiment, at least one temperature sensor is disposed within a channel defined by a body member that is disposed about the elongate shaft.

Systems and Methods for Treatment of BPH

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe from the urethra. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered. 1. A prostate therapy system comprising:a condensable vapor source; anda tissue extraction member adapted to be inserted into a urethra of an adult male human subject and to rotate within the urethra,the tissue extraction member having a vapor delivery port communicating with the vapor source and adapted to deliver condensable vapor to the prostate lobe and an aspiration port adapted to aspirate prostate tissue proximally into the ablation probe.2. The system of wherein the tissue extraction member further comprises a liquid ejection port communicating with a source of high pressure liquid.3. The system of wherein the liquid ejection port and high pressure liquid source are adapted and configured to eject high pressure liquid in pulses between 1 pulse/second and 100 pulses/second.4. The system of wherein the liquid ejection port is adapted and configured to eject high pressure liquid radially outward from a longitudinal axis of the tissue extraction member.5. The system of wherein the liquid ejection port is adapted and configured to eject high pressure liquid at an angle of between 10 degrees and 90 degrees from a longitudinal axis of the tissue extraction member.6. The system of wherein the liquid ejection port is concentric with the vapor delivery port.7. The system of further comprising a distal occlusion member adapted to occlude the urethra distal to the ...

Systems and methods for treatment of BPH

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe from the urethra. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered.

Methods for delivering energy into a target tissue of a body

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.

Intravascular temperature sensor

Devices and methods for detecting vulnerable plaque within a blood vessel are disclosed. A catheter in accordance with the present invention includes an elongate shaft having a proximal end, a distal end, and an outer surface. At least one temperature sensor is disposed proximate to the distal end of the elongate shaft. In one preferred embodiment, the at least one temperature sensor is adapted to contact inner surface of the blood vessel. In another preferred embodiment, at least one temperature sensor is disposed within a channel defined by a body member that is disposed about the elongate shaft.

Systems and Methods for Prostate Treatment

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the needle can ablate a continuous lobe region in the prostate parallel to the urethral wall. Another feature of the vapor delivery needle is that it can introduce a cooling fluid into the urethra during treatment. Methods associated with use of the energy delivery probe are also covered.

LUBRICANT COMPOSITION HAVING IMPROVED ANTIWEAR PROPERTIES

The instant invention provides a lubricant composition having improved four-ball antiwear properties. The lubricant composition includes a base oil and one or more alkylethercarboxylic acid corrosion inhibitor(s) having the formula: 2. A lubricant composition as set forth in wherein said corrosion inhibitor is present in an amount of from 0.03 to 0.5 weight percent based on a total weight percent of said lubricant composition.3. A lubricant composition as set forth in wherein said antiwear additive is present in an amount of from 0.01 to 0.05 weight percent based on a total weight percent of said lubricant composition.4. A lubricant composition as set forth in wherein said base oil comprises one or more customary additives and is present in an amount of at least 99.9 weight percent based on a total weight of said lubricant composition.5. A lubricant composition as set forth in wherein R comprises a Calkyl group and n is about 3.6. A lubricant composition as set forth in wherein the average diameter of the wear scars resulting from said lubricant composition are at least 10% smaller than the average diameter of the wear scars resulting from the standard.7. A lubricant composition as set forth in wherein the average diameter of the wear scars resulting from said lubricant composition are at least 20% smaller than the average diameter of the wear scars resulting from the standard.8. A lubricant composition as set forth in wherein the average diameter of the wear scars resulting from said lubricant composition are at least 50% smaller than the average diameter of the wear scars resulting from the standard.9. A lubricant composition as set forth in wherein R comprises a Calkyl group and n is about 3.10. A lubricant composition as set forth in that is free of water.11. A lubricant composition as set forth in having a FZG Scuffing Load Capacity of at least 12 as measured pursuant to ASTM D5182.12. A lubricant composition as set forth in wherein said corrosion inhibitor is ...

MEDICAL DEVICE WITH POROUS METL ELEMENT

An electrocautery instrument is provided with a hollow electrode having a source of conductive fluid coupled to a proximal end thereof. Conductive fluid is communicated through said electrode and expelled out of the distal end thereof during electrocautery, forming a “virtual electrode.” The infused conductive liquid conducts the RF electrocautery energy away from the conductive electrode, thereby displacing the region of thermal generation and reducing the extent of burns and perforations caused by conventional electrocautery electrodes. In one embodiment, the electrode is partially disposed within and extends distally out of a retractable suction tube, such that smoke and fluid are aspirated from the electrocautery site. When the suction tube is fully advanced, the electrode is concealed therein, enabling suction without electrocautery to be performed.

Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue

A method and apparatus for creating a virtual electrode to ablate bodily tissue. The apparatus includes an outer tube, a first electrode, an inner tube and a second electrode. The outer tube is fluidly connected to a source of conductive fluid and defines a proximal end and a distal end. The distal end includes an opening for delivering conductive fluid from the outer tube. The first electrode is disposed at the distal end of the outer tube for applying a current to conductive fluid delivered from the outer tube. The inner tube is coaxially received within the outer tube and is connected to a source of conductive fluid. The inner tube defines a proximal end and a distal end, with the distal end forming an opening for delivering conductive fluid from the inner tube. Finally, the second electrode is disposed at the distal end of the inner tube for applying a current to conductive fluid delivered from the inner tube. With this configuration, upon final assembly, the distal end of the outer ...

Vapor ablation systems and methods

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the vapor delivery needle can be advanced a predetermined distance into the prostate with a solenoid actuation mechanism. Methods associated with use of the energy delivery probe are also covered.

Alkoxylated amides, esters, and anti-wear agents in lubricant compositions

The present disclosure provides an additive package for a lubricant composition that includes an alkoxylated amide, an ester, and an anti-wear agent including phosphorus, molybdenum, or a combination thereof. The present disclosure also provides a lubricant composition that includes a base oil, the alkoxylated amide, the ester, and the anti-wear agent including phosphorus, molybdenum, or a combination thereof. The present disclosure further provides a method of lubricating an internal combustion engine for improving fuel economy.

VAPOR ABLATION SYSTEMS AND METHODS

A vapor delivery device is provided that may include any of a number of features. One feature of the vapor delivery device is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate tissues of the prostate. The vapor delivery device can include a handle portion and a cartridge portion. The cartridge portion can be configured to be inserted into a lumen of the handle portion to align and position a vapor coil of the cartridge portion within a RF coil of the handle portion. Methods associated with use of the energy delivery probe are also covered.

Apparatus for RF intraluminal reduction and occlusion

The present invention provides an apparatus method for performing rf intraluminal reduction and/or occlusion with a virtual electrode. An apparatus in accord with the present invention includes a catheter and a guide wire. The guide wire includes a conductive core having a proximal end electrically connected to a generator of rf current and an exposed distal end. An insulative material having disposed therein at least one microlumen for providing a conductive fluid to a target site within the lumen encases the guide wire.

Tissue sealing electrosurgery device and methods of sealing tissue

An electrosurgery medical device is enhanced with unique solution-assistance, and comprises, in combination, co-operating device jaws including jaw portions for manipulating tissue, and a plurality of solution infusion openings defined and spaced along each of the jaw portions, for receiving electrolytic solution and infusing the solution onto and into tissue to be manipulated, along said jaw portions. As preferred, the device further comprises at least one, and most preferably, many, longitudinal groove(s) along at least one and most preferably, both, of the jaw portions, with the solution infusion openings located in the groove or grooves. The solution is energized with RF energy and contributes to the functions and beneficial effects of the instrument. The solution exits the openings in the grooves at sufficient flow rates to separate substantially all the operative surfaces of the device from tissue, thereby substantially completely preventing adherence between the operative surfaces ...

Surgical devices and methods for use in tissue ablation procedures

Devices and a method are provided to assist a surgeon in ablating conduction paths in tissue, such as a heart. A device can be configured to operate as a template that adheres to the tissue surface, and allows the surgeon to more easily sever the conduction path to form a lesion in a desired location. In particular, the template can be used to guide the surgeon's use of a surgical instrument along a desired ablation path. In some case, the template may incorporate hardware that structurally supports the instrument for travel along the ablation path. A surgical instrument such as an ablation probe, e.g., radio frequency, laser, ultrasonic, microwave, thermal, chemical, mechanical, or cryogenic ablation probe, may be used to sever the conduction paths. Measurements made substantially contemporaneously with the conduction path ablation operation may be used to evaluate whether the desired degree of ablation has been achieved. The device may also incorporate feedback to compare the desired ...

VAPOR ABLATION SYSTEMS AND METHODS

A vapor delivery system and method is provided that includes a number of features. In one embodiment, a method comprises inserting a vapor delivery needle into tissue of a patient, activating a flow of vapor from a vapor generator through vapor delivery ports of the vapor delivery needle to cause condensed liquid to exit vapor delivery ports of the vapor delivery needle, generating vapor in the vapor generator, delivering a dose of vapor through the vapor delivery ports of the vapor delivery needle into the tissue, and after the dose of vapor is delivered, re-activating the flow of vapor from the vapor generator through the vapor delivery ports of the vapor delivery needle to prevent a vacuum from forming in the vapor delivery needle. Vapor therapy systems are also provided. 115-. (canceled)16. A vapor delivery system , comprising:a shaft configured to be inserted into a urethra of a patient;a vapor delivery needle disposed within the shaft and including a lumen in fluid communication with a vapor delivery port;a vapor source in fluid communication with the lumen of the vapor delivery needle; and deliver a treatment dose of vapor from the vapor source through the vapor delivery port of the vapor delivery needle; and', 'automatically deliver an interim flow of vapor from the vapor source through the vapor delivery port of the vapor delivery needle to introduce positive pressure in the lumen of the vapor delivery needle after delivery of the treatment dose, wherein an amount of vapor in the interim flow is less than an amount of vapor in the treatment dose., 'an electronic controller configured to17. The system of claim 16 , wherein the flow rate of the interim flow of vapor ranges from approximately 0.1 ml/minute to 0.3 ml/minute.18. The system of claim 16 , wherein the treatment dose is a first treatment dose and wherein the controller is further configured to claim 16 , after delivering the interim flow of vapor claim 16 , deliver a second treatment dose of vapor ...

ANATOMICAL/PHYSIOLOGICAL EVENT APPARATUS AND METHOD OF TREATING AN APPROACHING

A neuromodulation device and method capable of varying a neuromodulation therapy in order to prevent, delay or control a sexual emission.

Lubricating oil composition for marine engines

The lubricating compositions of the present invention are designed for use in a four stroke outboard marine engine and contain an oil of lubricating viscosity, an ashless dispersant, a metal detergent, a rust inhibitor system comprising a combination of certain rust inhibitors with an ethoxylated alkyl phenol, a relatively high amount of ZDDP, and an amount of a molybdenum compound sufficient to provide the composition with 15-1,000 ppm by mass of molybdenum. An amount of about 15 ppm to 1,000 ppm by mass of molybdenum from a molybdenum compound has been found to be effective as an antiwear agent in combination with the high levels of ZDDP.

Tissue sealing electrosurgery device and methods of sealing tissue

An electrosurgery medical device is enhanced with unique solution-assistance, and comprises, in combination, co-operating device jaws including jaw portions for manipulating tissue, and a plurality of solution infusion openings defined and spaced along each of the jaw portions, for receiving electrolytic solution and infusing the solution onto and into tissue to be manipulated, along said jaw portions. As preferred, the device further comprises at least one, and most preferably, many, longitudinal groove(s) along at least one and most preferably, both, of the jaw portions, with the solution infusion openings located in the groove or grooves. The solution is energized with RF energy and contributes to the functions and beneficial effects of the instrument. The solution exits the openings in the grooves at sufficient flow rates to separate substantially all the operative surfaces of the device from tissue, thereby substantially completely preventing adherence between the operative surfaces ...

Medical probes for the treatment of blood vessels

Devices and methods for thermally-mediated treatment of blood vessels to elicit an immune response to cause rapid endothelial growth over at least portions of an implant or stent to prevent adverse events such as restenosis. Devices and methods for thermally-mediated treatment to inhibit contraction of vessels to elicit an immune response to cause rapid endothelial growth over at least portions of a stent to prevent adverse events such as restenosis.

Systems and methods for treating the bladder with condensable vapor

A vapor delivery system and method is provided that is adapted for ablating bladder tissue to treat overactive bladder (OAB). The vapor delivery system includes an anchor tip configured anchor the system in the bladder while condensable vapor is delivered to target tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the target tissue of the bladder, which can include a surface sensor of the bladder responsible for creating an urge incontinence sensation. The vapor delivery system includes a vapor source that provides a high quality vapor for delivery to tissue.

Systems and methods for treating the prostate

A vapor delivery system and method is provided that is adapted for treating prostate tissue. The vapor delivery system includes a vapor delivery needle configured to deliver condensable vapor energy to tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the prostate tissue. The vapor delivery system is properly positioned by measuring and advancing the system based on a field-of-view of an endoscope or camera disposed within the system.

Systems and methods for treatment of BPH

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe from the urethra. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered.

Intrapericardial MRI device and method

A catheter based loop antenna is delivered to the pericardial space through an opening in the chest. The size of the antenna may be modified to selectively view tissue for imaging or spectrographic analysis purposes.

MEDICAL SYSTEM AND METHOD OF USE

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.

Systems and Methods for Prostate Treatment

An energy delivery probe is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the energy can be applied with a vapor media. Another feature of the energy delivery probe is that it can deploy a stent to apply tissue-compressive forces to the prostate tissue after energy delivery. Methods associated with use of the energy delivery probe are also covered.

Induction coil vapor generator

An induction coil vapor generator is provided that may include any of a number of features. One feature of the vapor generator is that it can inductively generate high quality condensable vapor. The vapor generator can comprise an outer assembly that supports a coil wire, and an inner assembly disposed in the outer assembly. The inner assembly can house a plurality of microtubes configured to be inductively heated by the coil wire to convert a fluid to condensable vapor. The generator can be disposed in a medical device to treat tissue with vapor. One feature of the medical device is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. Methods associated with use of the vapor generator are also covered.

Lubricant composition

A lubricant composition is substantially free of water and includes a base oil present in an amount of greater than 85 parts by weight per 100 parts by weight of the lubricant composition, includes an antioxidant, and includes one or more alkylethercarboxylic acid corrosion inhibitor(s) present in an amount of from 0.01 to 1 weight percent based on a total weight of said lubricant composition. The one or more alkylethercarboxylic acid corrosion inhibitor(s) have the formula; wherein R is a straight or branched chain C6-C18 alkyl group and n is a number of from 0 to 5.

Vapor ablation systems and methods

A vapor delivery system and method is provided that is adapted for treating prostate tissue. The vapor delivery system includes a vapor delivery needle configured to deliver condensable vapor energy to tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the prostate tissue. The vapor delivery system includes a generator unit and an inductive heating system to produce a high quality vapor for delivery to tissue. Methods of use are also provided.

Lubrican composition comprising acyclic hindered amines

A lubricant composition including an acyclic amine compound. A method of lubricating a system including a fluoro-polymer seal with the lubricant composition is also provided. An additive concentrate for a lubricant composition is also provided. The acyclic amine compound is useful for adjusting the total base number of a lubricant composition. The lubricant composition is compatible with fluoropolymer seals.

TISSUE EVACUATION DEVICE

A tissue evacuation device may be designed to provide a high-energy fluid (e.g., a heated vapor) to targeted tissue for breaking down the targeted tissue, such as the nucleus of an intervertebral disc. An inner tube positioned within an outer tube, having a nozzle coupled to distal ends of the tubes, having a heating element positioned between the inner and outer tubes, delivers a heated vapor through a port to the nozzle to break down tissue. After the nucleus or other targeted tissue is broken down, the tissue evacuation device may also remove some or all of the broken down tissue.

Pen-type electrosurgical instrument

An electrocautery device is disclosed. In accordance with one aspect of the invention, the electrocautery electrode/tip is provided with a hollow, conductive tube terminating at its distal end in a ball point type tip. Fluid, preferably conductive fluid, is applied to the proximal end of the hollow electrode/tip, and expelled from the distal end thereof during electrocautery. The ball point distal tip allows the distal tip to be directly applied to the tissue and “rolled” or slid along the tissue. This allows the distal tip to be moved across the tissue without dragging or snagging on the tissue. In addition, the conductive fluid expelled from the distal tip further lubricates the distal tip as it moves across the tissue. If conductive fluid is used, the conductive fluid emanating from the electrode/tip conducts the RF electrocautery energy away from the distal tip so that it is primarily the fluid, rather than the distal tip that actually accomplishes the cauterizing of tissue. That is ...

Systems and methods for treatment of prostatic tissue

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Methods associated with use of the prostate therapy system are also covered.

Method of irrigated ablation

A device for ablating tissue is provided. The device comprises a conductive element with a channel for irrigating fluid formed therein, which is in contact with a non-conductive microporous interface. All or a portion of the interface may be removable. When the interface is removed, a portion of the conductive element is exposed for use in ablating tissue. Methods of using the device and of removing the interface are also provided.

Systems and methods for treating prostate cancer

A vapor delivery needle and method is provided that is adapted for treating prostate cancer. The energy delivery probe can apply condensable vapor energy to tissue, such as a peripheral zone tissue in a human prostate. In one method, a needle is introduced into peripheral zone tissue of a human prostate, and vapor media is delivered through the needle to ablate peripheral zone tissue without ablating non-peripheral zone tissue. Systems for treating prostate cancer with vapor therapy are also provided.

Systems and Methods for Treatment of BPH

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe from the urethra. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered.

APPARATUS AND METHOD OF TREATING AN APPROACHING PHYSIOLOGICAL EVENT AND INCREASING AN INTENSITY OF THE EVENT

A flexible neuromodulation device and method capable of varying a neuromodulation therapy in order to prevent, delay, or control a sexual emission, and/or increasing an intensity of a sexual climax.

Systems and Methods for Prostate Treatment

An energy delivery probe is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the energy can be applied with a vapor media. The energy delivery probe can include a vapor delivery member configured to extend into a transition zone prostate tissue. A condensable vapor media can be delivered from the vapor delivery member into the transition zone tissue, wherein the condensable vapor media can propagate interstitially in the transition zone tissue and be confined in the transition zone tissue by boundary tissue adjacent to the transition zone tissue Methods associated with use of the energy delivery probe are also covered.

APPARATUS AND METHOD OF TREATING AN APPROACHING PHYSIOLOGICAL EVENT AND INCREASING AN INTENSITY OF THE EVENT

A flexible neuromodulation device and method capable of varying a neuromodulation therapy in order to prevent, delay, or control a sexual emission, and/or increasing an intensity of a sexual climax.

SYSTEMS AND METHODS FOR TREATING THE BLADDER WITH CONDENSABLE VAPOR

A vapor delivery system and method is provided that is adapted for ablating bladder tissue to treat overactive bladder (OAB). The vapor delivery system includes an anchor tip configured anchor the system in the bladder while condensable vapor is delivered to target tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the target tissue of the bladder, which can include a surface sensor of the bladder responsible for creating an urge incontinence sensation. The vapor delivery system includes a vapor source that provides a high quality vapor for delivery to tissue.

Device and method for ablating tissue

An electrosurgery medical device is enhanced with unique solution-assistance, and comprises, in combination, co-operating device jaws including jaw portions for manipulating tissue, and a plurality of solution infusion openings defined and spaced along each of the jaw portions, for receiving electrolytic solution and infusing the solution onto and into tissue to be manipulated, along said jaw portions. As preferred, the device further comprises at least one, and most preferably, many, longitudinal groove(s) along at least one and most preferably, both, of the jaw portions, with the solution infusion openings located in the groove or grooves. The solution is energized with RF energy and contributes to the functions and beneficial effects of the instrument. The solution exits the openings in the grooves at sufficient flow rates to separate substantially all the operative surfaces of the device from tissue, thereby substantially completely preventing adherence between the operative surfaces ...

VAPOR ABLATION SYSTEMS AND METHODS

A vapor delivery system and method is provided that includes a number of features. In one embodiment, a method comprises inserting a vapor delivery needle into tissue of a patient, activating a flow of vapor from a vapor generator through vapor delivery ports of the vapor delivery needle to cause condensed liquid to exit vapor delivery ports of the vapor delivery needle, generating vapor in the vapor generator, delivering a dose of vapor through the vapor delivery ports of the vapor delivery needle into the tissue, and after the dose of vapor is delivered, re-activating the flow of vapor from the vapor generator through the vapor delivery ports of the vapor delivery needle to prevent a vacuum from forming in the vapor delivery needle. Vapor therapy systems are also ...

Lubricant composition comprising hindered cyclic amines

A lubricant composition includes a base oil and a cyclic amine compound. A method of lubricating a system including a fluoropolymer seal with the lubricant composition is also provided. An additive concentrate for a lubricant composition is also provided. The cyclic amine compound is useful for adjusting the total base number of a lubricant composition. The lubricant composition is compatible with fluoropolymer seals.

Myocardial constraint

A method and apparatus for treating congestive heart failure by converting the pericardium into a myocardial constraint is described along with techniques for achieving the goal.

MEDICAL DEVICES AND METHODS

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, or denature tissues of the prostate. Methods associated with use of the energy delivery probe are also covered.

Vapor ablation systems and methods

A vapor delivery device is provided that may include any of a number of features. One feature of the vapor delivery device is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate tissues of the prostate. The vapor delivery device can include a handle portion and a cartridge portion. The cartridge portion can be configured to be inserted into a lumen of the handle portion to align and position a vapor coil of the cartridge portion within a RF coil of the handle portion. Methods associated with use of the energy delivery probe are also covered.

Medical system and method of use

An instrument and method for applying thermal energy to targeted tissue. An instrument and method for tissue thermotherapy. In one embodiment, a method includes providing a vapor source comprising a pump configured for providing a flow of liquid media from a liquid media source into a vaporization chamber having a heating mechanism, actuating the pump to provide the liquid into the vaporization chamber, applying energy from the heating mechanism to convert a substantially water liquid media into a minimum water vapor level for causing an intended effect in tissue. For examples such levels can comprise at least 60% water vapor, at least 70% water vapor, at least 80% water vapor or at least 90% water vapor for causing an intended effect in tissue.

Systems and methods for prostate treatment

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the needle can ablate a continuous lobe region in the prostate parallel to the urethral wall. Another feature of the vapor delivery needle is that it can introduce a cooling fluid into the urethra during treatment. Methods associated with use of the energy delivery probe are also covered.

Medical instrument and method of use

An instrument for thermally-mediated therapies in targeted tissue volumes or for volumetric removal of tissue. In one embodiment, the instrument has an interior chamber that includes a diffuser structure for diffusing a biocompatible conductive fluid that is introduced under high pressure. The interior chamber further includes surfaces of opposing polarity electrodes for vaporizing the small cross-section diffused fluid flows created within a diffuser structure. In one embodiment, the diffuser structure includes a negative temperature coefficient of resistance material between the opposing polarity surfaces. The NTCR structure can self-adjust the lengths of current paths between the opposing polarities to insure complete vaporization of the volume of flow of conductive fluid. The non-ionized vapor phase media is ejected from a working surface of the instrument and a controlled vapor-to-liquid phase change in an interface with tissue applies thermal energy substantially equal to the heat ...

Vapor ablation systems and methods

A vapor delivery system and method is provided that is adapted for treating prostate tissue. The vapor delivery system includes a vapor delivery needle configured to deliver condensable vapor energy to tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the prostate tissue. The vapor delivery system includes a generator unit and an inductive heating system to produce a high quality vapor for delivery to tissue. Methods of use are also provided.

Surgical devices and methods for use in tissue ablation procedures

Methods are provided to assist a surgeon in ablating conduction paths in tissue, such as a heart. In one embodiment, the invention presents a method that includes placing a guide in contact with the tissue to be ablated, applying an ablation probe to the tissue using the guide to assist in control of movement of the ablation probe, measuring the effectiveness of the ablation probe in ablation of the conduction paths, and deactivating the ablation probe when the measured effectiveness meets a desired level. Placement of the guide in contact with the tissue allows the surgeon to more easily sever the conduction path to form a lesion in a desired location.

Systems and methods for male sterilization

An energy delivery probe is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply energy to tissue, such as a duct, to shrink, damage, or occlude the duct. In some embodiments, the energy can be applied with a vapor media. In some embodiments, the duct can be a ductus deferens or an ejaculatory duct of the male reproductive system. Another feature of the energy delivery probe is that it can utilize an inflatable member to form a seal to contain the vapor media. Methods associated with use of the energy delivery probe are also covered.

Medical system and method of use

A tissue evacuation device may be designed to provide a high-energy fluid (e.g., a heated vapor) to targeted tissue for breaking down the targeted tissue, such as the nucleus of an intervertebral disc. An inner tube positioned within an outer tube, having a nozzle coupled to distal ends of the tubes, having a heating element positioned between the inner and outer tubes, delivers a heated vapor through a port to the nozzle to break down tissue. After the nucleus or other targeted tissue is broken down, the tissue evacuation device may also remove some or all of the broken down tissue.

Systems and methods for treating the prostate

A vapor delivery system and method is provided that is adapted for treating prostate tissue. The vapor delivery system includes a vapor delivery needle configured to deliver condensable vapor energy to tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the prostate tissue. The vapor delivery system is properly positioned by measuring and advancing the system based on a field-of-view of an endoscope or camera disposed within the system.

Systems and Methods for Prostate Treatment

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the needle can ablate a continuous lobe region in the prostate parallel to the urethral wall. Another feature of the vapor delivery needle is that it can introduce a cooling fluid into the urethra during treatment. Methods associated with use of the energy delivery probe are also covered.

Methods for delivering energy into a target tissue of a body

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery.

Helical needle apparatus for creating a virtual electrode used for the ablation of tissue

A surgical apparatus for delivering a conductive fluid to a target site for subsequent formation of a virtual electrode to ablate bodily tissue at the target site by applying a current to the delivered conductive fluid. The surgical apparatus includes an elongated device forming a helical needle. The helical needle is configured to engage bodily tissue and is hollow for delivering conductive fluid from a fluid source. Finally, the helical needle terminates in a needle tip. In one preferred embodiment, an electrode is associated with the helical needle for applying a current to conductive fluid delivered from the helical needle. During use, following delivery of conductive fluid, the electrode applies a current to the delivered conductive fluid for creating a virtual electrode. The virtual electrode ablates bodily tissue contacted by the conductive fluid.

Medical instrument and method of use

An instrument for thermally-mediated therapies in targeted tissue volumes or for volumetric removal of tissue. In one embodiment, the instrument has an interior chamber that includes a diffuser structure for diffusing a biocompatible conductive fluid that is introduced under high pressure. The interior chamber further includes surfaces of opposing polarity electrodes for vaporizing the small cross-section diffused fluid flows created within a diffuser structure. In one embodiment, the diffuser structure includes a negative temperature coefficient of resistance material between the opposing polarity surfaces. The NTCR structure can self-adjust the lengths of current paths between the opposing polarities to insure complete vaporization of the volume of flow of conductive fluid. The non-ionized vapor phase media is ejected from a working surface of the instrument and a controlled vapor-to-liquid phase change in an interface with tissue applies thermal energy substantially equal to the heat ...

Treatment with high temperature vapor

Methods are describe for treating intraluminal locations such as in a patient's lung. The device is a catheter which has an elongated shaft with an inner lumen, preferably defined by an inner tubular member, formed of heat resistant polymeric materials such as polyimide and high temperature vapor is directed through the inner lumen into the intraluminal location to treat tissue at and/or distal to the location. The outer surface of the catheter is also formed of heat resistant material. An enlarged or enlargeable member, such as a balloon, is provided on a distal portion of the catheter shaft to prevent proximal flow of the high temperature vapor upon discharge from the catheter.

Alkoxylated amides, esters, and anti-wear agents in lubricant compositions and racing oil compositions

A lubricant composition includes a base oil, an alkoxylated amide, an ester, and an anti-wear agent including phosphorus. The alkoxylated amide and ester have general formulas (I) and (II), respectively. The lubricant composition may be further defined as a racing oil composition. Also disclosed is a method for maximizing the effectiveness of a friction modifier in a racing oil composition thus increasing the fuel economy of a racing vehicle. The method includes providing the racing oil composition and lubricating an internal combustion engine of a racing vehicle to increase the fuel economy of the racing vehicle.

TRANSPERINEAL VAPOR ABLATION SYSTEMS AND METHODS

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, or denature tissues of the prostate. Methods associated with use of the energy delivery probe are also covered. 115.-. (canceled)16. A vapor delivery device comprising:a shaft;a first electrode disposed at a distal tip of the shaft, wherein the first electrode is configured to measure a first electrical impedance of a first tissue contacting the first electrode;a second electrode disposed on the shaft, proximally of the first electrode, wherein the second electrode is configured to measure a second electrical impedance of a second tissue contacting the second electrode; andan electrically insulative material disposed between the first electrode and the second electrode; andan electronic controller configured to use the first electrical impedence and the second electrical impedence in order to determine whether the first electrode and the second electrode are disposed within a prostate.17. The vapor delivery device of claim 16 , wherein the second electrode is a ring electrode.18. The vapor delivery device of claim 16 , wherein the first electrode is configured to measure a first phase shift of the first tissue.19. The vapor delivery device of claim 18 , wherein the second electrode is configured to measure a second phase shift of the second tissue.20. The vapor delivery device of claim 19 , wherein the controller is configured to use the first phase shift and the second phase shift in order to determine whether the first electrode and the second electrode are disposed within the prostate.21. The vapor delivery device of claim 16 , wherein the shaft includes at least one hole configured to delivery vapor to the prostate.22. The vapor delivery device of claim 16 , further comprising circuitry electrically connected to the first electrode and the second ...

Tissue discrimination and applications in medical procedures

A system and method for discriminating tissue types, controlling the level of therapy to tissue, and determining the health or a known tissue by measuring the characteristics an electrical signal applied to conductive element located within or by the tissue. Additionally, the system and method may be used for determining whether the conductive tip of a pedicle probe or pedicle screw is located in one of cortical bone, cancellous bone, and cortical bone near a boundary with soft tissue, whether the conductive tip of a cannula is located adjacent to one of nerve tissue and annulus tissue, and whether the conductive tip of a cathode is located adjacent to one of nerve tissue and prostate gland tissue.

Inducing desirable temperature effects on body tissue

Methods and systems are disclosed for treating diseased tissue by gentle heating. The method induces vasodilation on tissue disposed about an lumen having both healthy tissue and diseased tissue. The method includes coupling a probe surface to the luminal tissue at a target location and transmitting desired quantities of tissue remodeling energy from the coupled probe into each of a plurality of discrete remodeling zones in the luminal tissue so that the tissue remodeling energy heats the plurality of remodeling zones, the remodeling energy being configured to avoid muscular contraction and inhibit both acute and long-term occlusion of the lumen. 1. A system for remodeling tissue disposed about a blood vessel , the system comprising:an endovascular catheter having an energy delivery portion coupleable with the tissue at a target location, the energy delivery portion having a plurality of energy delivery regions; andan energy source coupleable with the catheter, the energy source configured to deliver controlled quantities of energy to the energy delivery portion thereby transmitting desired quantities of tissue remodeling energy to each of the energy delivery regions in response to an input such that the energy heats a plurality of remodeling zones of the tissue, the remodeling energy being configured to remodel the tissue and inhibit thermal damage of collateral healthy tissues.2. The system of claim 1 , wherein the energy delivery portion comprises a balloon and the plurality of energy delivery regions comprise a plurality of bipolar electrode pairs spaced around an axis of the balloon so that the plurality of remodeling zones defined by the bipolar electrode pairs are laterally separated from each other forming gaps between adjacent remodeling zones about the axis of the balloon.3. The system of claim 2 , wherein the energy source is configured to energize different bipolar electrode pairs so as to eliminate the gaps about the axis of the balloon between ...

Tuned rf energy for selective treatment of atheroma and other target tissues and/or structures

A catheter and catheter system can use energy tailored for remodeling and/or removal of target material along a body lumen, often of atherosclerotic material of a blood vessel of a patient. An elongate flexible catheter body with a radially expandable structure may have a plurality of electrodes or other electrosurgical energy delivery surfaces to radially engage atherosclerotic material when the structure expands. An atherosclerotic material detector system may measure and/or characterize the atherosclerotic material and its location, optionally using impedance monitoring.

TUNED RF ENERGY AND ELECTRICAL TISSUE CHARACTERIZATION FOR SELECTIVE TREATMENT OF TARGET TISSUES

A catheter and catheter system can use energy tailored for remodeling and/or removal of target material along a body lumen, often of atherosclerotic material of a blood vessel of a patient. An elongate flexible catheter body with a radially expandable structure may have a plurality of electrodes or other electrosurgical energy delivery surfaces to radially engage atherosclerotic material when the structure expands. An atherosclerotic material detector system may measure and/or characterize the atherosclerotic material and its location, optionally using impedance monitoring. 1. A catheter system for remodeling of a target tissue adjacent a blood vessel of a patient , the system comprising:an elongate flexible catheter body having a proximal end and a distal end with an axis therebetween;at least one energy delivery surface disposed near the distal end of the catheter body; anda power source electrically coupled to the energy delivery surface(s), the power source configured to energize the energy delivery surface(s) with a controlled electrical energy that heats the target tissue so as to remodel the tissue.2. The catheter system of claim 1 , wherein the at least one energy delivery surface comprises a plurality of electrodes claim 1 , and the system further comprises:a radially expandable structure supporting the plurality of electrodes so as to radially engage the plurality of electrodes against the vessel wall when expanded within the blood vessel.3. The catheter system of claim 2 , wherein the plurality of electrodes comprise one or more flex circuits mounted to the expandable structure.4. The catheter system of wherein the radially expandable structure comprises a balloon.5. The catheter system of claim 4 , wherein each of the one or more flex circuit(s) comprise bipolar electrode pairs and/or sub-arrays of electrodes thereon.6. The catheter system of claim 2 , wherein the plurality of electrodes define a circumferentially distributed electrode array.7. The ...

System for inducing desirable temperature effects on body tissue

A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engage tissue including diseased tissue when the structure expands. 1. A system for inducing desirable temperature effects on a body tissue disposed about a blood vessel , the system comprising:a catheter body having a proximal end and a distal end with an axis therebetween;a radially expandable member supported by the distal end of the catheter body,the expandable member having a low profile insertion configuration and a larger profileconfiguration; anda plurality of electrodes disposed about the expandable member so as to radially couple with a wall of the blood vessel and define a plurality of remodeling zones in the tissue when the expandable member is in the large profile configuration within the blood vessel, the electrodes configured to transmit a tissue remodeling energy between the electrodes and the tissue while inhibiting damage to the blood vessel.2. The system of claim 1 , wherein the radially expandable member comprises a balloon claim 1 , wherein the electrodes are mounted on a surface of the balloon arranged in an array.3. The system of claim 2 , wherein the electrodes are circumferentially and axially offset.4. The system of claim 2 , wherein the plurality of electrodes are included in a plurality of separate flexible circuits distributed on the balloon.5. The system of claim 4 , wherein each of the flexible circuits includes an associated bipolar electrode pair.6. The system of claim 5 , wherein the electrodes of each bipolar electrode pair are disposed on a substrate of the associated flexible circuit so as to have a predetermined bipolar pair separation distance therebetween when the balloon is in the large profile configuration.7. The system of claim 6 , wherein each electrode comprises a plurality of pads claim ...

Systems and Methods for Male Sterilization

An energy delivery probe is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply energy to tissue, such as a duct, to shrink, damage, or occlude the duct. In some embodiments, the energy can be applied with a vapor media. In some embodiments, the duct can be a ductus deferens or an ejaculatory duct of the male reproductive system. Another feature of the energy delivery probe is that it can utilize an inflatable member to form a seal to contain the vapor media. Methods associated with use of the energy delivery probe are also covered. 1. A male sterilization method comprising:advancing a vapor delivery tool into or proximate to a duct of a male reproductive system; anddelivering vapor media through the vapor delivery tool into the duct to occlude the duct.2. The method of further comprising claim 1 , prior to the advancing step:introducing the vapor delivery tool into or proximate to a patient's prostate.3. The method of wherein the introducing step further comprises transurethrally introducing the vapor delivery tool into or proximate to the patient's prostate.4. The method of wherein the introducing step further comprises introducing an endoscope through the patient's urethra to the prostate; andintroducing the vapor delivery tool through a channel in the endoscope.5. The method of further comprising manipulating a distal end of the vapor delivery tool into or proximate to the duct.6. The method of wherein the advancing step comprises advancing the vapor delivery tool through a skin incision.7. The method of further comprising forming a seal in the patient's urethra to contain the vapor media.8. The method of wherein the seal directs the vapor media into the duct.9. The method of wherein the step of forming the seal includes expanding an expandable member.10. The method of wherein the step of forming the seal includes expanding an expandable portion of the vapor delivery tool.11. The method of wherein ...

MEDICAL SYSTEM AND METHOD OF USE

Medical instruments and systems for applying energy to tissue, and more particularly relates to systems for ablating or damaging structures in a body or vessel wall to alter electrical conduction therein to cause an intended therapeutic effect. Variations include devices and methods for generating a high pressure flow of a liquid media and/or a vapor media to treat the targeted tissue by the application of mechanical energy, thermal energy or chemical energy to such targeted tissue. 1. A method for treating a renal nerve within a body , the method comprising:advancing a catheter system into the body to a renal artery through a vascular path, where the catheter system comprises an elongated instrument with a working end surface having a flow media outlet exiting at the working end surface, the flow media outlet in communication with a flow channel, where the catheter system is coupled to a source of a flow media;positioning the working end surface in contact with the wall of the renal artery such that the flow media outlet is adjacent to or in contact with the wall; anddelivering the flow media through the flow channel and flow media outlet to the wall of the renal artery, where the flow media delivers energy to tissue within the wall to damage nerve fibers within the wall to alter an electrical signal transmission characteristic of the wall of the renal artery.2. The method of wherein the flow media comprises a flow media selected from the group consisting of water vapor claim 1 , water droplets claim 1 , a gas claim 1 , a liquid and a condensable vapor.3. The method of claim 1 , where the flow media is propagated across a surface of the wall to apply energy in the interior of the wall.4. The method of claim 1 , where the energy delivered by the flow media comprises either mechanical or thermal energy sufficient to modify the tissue within the wall.5. The method of claim 1 , further comprising penetrating the wall of the vessel with a needle-type member to deliver ...

Systems and Methods for Treatment of Prostatic Tissue

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it includes a cutter that can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered. 1. A prostate therapy system , comprising:a tissue extraction member adapted to be transurethrally inserted into a patient's prostate;a rotational cutter disposed in the tissue extraction member, the rotational cutter being configured to rotate within the prostate to volumetrically remove prostate tissue substantially without damage to the patient's urethra;a condensable vapor source; anda vapor delivery port disposed in the tissue extraction member, the vapor delivery port being in communication with the condensable vapor source to deliver condensable vapor to the prostate to seal a margin of the removed prostate tissue.2. The system of further comprising an imaging system adapted to identify anatomical landmarks of the patient.3. The system of wherein the system is adapted to deliver between approximately 100 W and 1000 W of energy from the condensable vapor to the prostate.4. The system of wherein the rotational cutter is adapted to rotate between approximately 50 rpm to 20 claim 1 ,000 rpm.5. The system of further comprising a motor coupled to the rotational cutter and adapted to rotate the rotational cutter.6. The system of further comprising a cutout along a distal end of the tissue extraction member to reveal the rotational cutter.7. The system of wherein an outer diameter of the rotational cutter is configured to fit precisely ...

MEDICAL INSTRUMENT AND METHOD OF USE

An instrument for thermally-mediated therapies in targeted tissue volumes or for volumetric removal of tissue. In one embodiment, the instrument has an interior chamber that includes a diffuser structure for diffusing a biocompatible conductive fluid that is introduced under high pressure. The interior chamber further includes surfaces of opposing polarity electrodes for vaporizing the small cross-section diffused fluid flows created within a diffuser structure. In one embodiment, the diffuser structure includes a negative temperature coefficient of resistance material between the opposing polarity surfaces. The NTCR structure can self-adjust the lengths of current paths between the opposing polarities to insure complete vaporization of the volume of flow of conductive fluid. The non-ionized vapor phase media is ejected from a working surface of the instrument and a controlled vapor-to-liquid phase chance in an interface with tissue applies thermal energy substantially equal to the heat of vaporization to ablate tissue. In another embodiment, the instrument provides voltage means for converting the non-ionized vapor phase media into an ionized media or plasma for applying energy to body structure. 2. The method of including providing claim 1 , the flow of non-ionized flow media from a needle-like working end into the body structure.3. The method of including providing the flow of non-ionized flow media from the working end into at least one of as body lumen claim 1 , soft tissue claim 1 , surface tissue and bone.4. The method of including providing the flow of non-ionized flow media in at least one of a distal direction relative to a probe axis claim 1 , a proximal direction relative the said axis and substantially perpendicular to said axis.5. The method of including providing the flow of non-ionized flow media from at least one proximally-oriented port into said interior channel in the probe.6. The method of including providing negative pressure aspiration forces ...

Medical system and method of use

An instrument and method for applying thermal energy to targeted tissue. An instrument and method for tissue thermotherapy. In one embodiment, a method includes providing a vapor source comprising a pump configured for providing a flow of liquid media from a liquid media source into a vaporization chamber having a heating mechanism, actuating the pump to provide the liquid into the vaporization chamber, applying energy from the heating mechanism to convert a substantially water liquid media into a minimum water vapor level for causing an intended effect in tissue. For examples such levels can comprise at least 60% water vapor, at least 70% water vapor, at least 80% water vapor or at least 90% water vapor for causing an intended effect in tissue.

Lubricant composition comprising unhindered alkyl amines

A lubricant composition including a base oil and from 0.01 to 10 wt. % of an amine compound based on a total weight of the lubricant composition. The amine compound has the formula R 1 (R 2 )NH, where R 1 and R 2 are each independently straight or branched chain acyclic alkyl groups having from 1 to 20 carbon atoms. The alpha carbon of R 1 or R 2 is primary if R 1 or R 2 is an alkyl group having more than one carbon atom respectively. At least 90 wt. % of the amine compound remains unreacted in the lubricant composition based on a total weight of the amine compound prior to any reaction in the lubricant composition.

SYSTEM FOR INDUCING DESIRABLE TEMPERATURE EFFECTS ON BODY TISSUE

A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engage tissue including diseased tissue when the structure expands. 1. A system , comprising:a catheter body having a proximal end and a distal end with an axis therebetween;a radially expandable member having a low profile insertion configuration and a larger profile configuration; anda plurality of electrode pairs included on a plurality of flexible circuits, the flexible circuits distributed about an outer surface of the expandable member, so as to define a plurality of remodeling zones extending circumferentially about a wall of a body lumen when the expandable member is in the larger profile configuration; andwherein the plurality of electrode pairs is configured to transmit a tissue remodeling energy to each of the plurality of remodeling zones such that the tissue remodeling energy transmitted to remodeling zones including both a target tissue and a collateral tissue heats the target tissue sufficiently to efficaciously alter the target tissue without causing thermal damage to the collateral tissue.2. The system of claim 1 , wherein each of the flexible circuits includes an associated bipolar electrode pair.3. The system of claim 2 , wherein the electrodes of each bipolar electrode pair are disposed on its associated flexible circuit so as to have a predetermined bipolar pair separation distance therebetween when the expandable member is in the larger profile configuration.4. The system of claim 2 , wherein the bipolar electrode pairs are configured to be energized with RF energy claim 2 , and wherein the electrodes of the electrode pairs are circumferentially separated.5. The system of claim 4 , wherein a circumferential distance between the electrodes of the electrode pairs is within a range from about 0.25 to 2.5 mm.6. The ...

SYSTEMS AND METHODS FOR PROSTATE TREATMENT

An energy delivery probe is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the energy can be applied with a vapor media. The energy delivery probe can include a vapor delivery member configured to extend into a transition zone prostate tissue. A condensable vapor media can be delivered from the vapor delivery member into the transition zone tissue, wherein the condensable vapor media can propagate interstitially in the transition zone tissue and be confined in the transition zone tissue by boundary tissue adjacent to the transition zone tissue. Methods associated with use of the energy delivery probe are also covered. 126.-. (canceled)27. A medical device , comprising:a handle portion configured to be gripped by a hand of an operator;an introducer portion extending from a proximal end toward a distal tip and configured to be inserted into a urethra of a patient, the introducer portion defining a lumen extending along a longitudinal axis of the introducer portion from the proximal end toward the distal tip; anda needle disposed in the lumen, wherein the needle defines a channel configured to be in fluid communication with a source of vapor, and wherein a distal portion of the needle includes at least one outlet in fluid communication with the channel;wherein the device is configured to be transitioned from a first configuration to a second configuration, wherein, in the first configuration, the distal portion of the needle is within the lumen, and wherein, in the second configuration, the distal portion of the needle extends out of a distal opening of the lumen such that the distal portion of the needle is transverse to the longitudinal axis of the introducer portion.28. The device of claim 27 , wherein the lumen is a first lumen claim 27 , and wherein the introducer portion further defines a ...

SYSTEMS AND METHODS FOR TREATING PROSTATE CANCER

A vapor delivery needle and method is provided that is adapted for treating prostate cancer. The energy delivery probe can apply condensable vapor energy to tissue, such as a peripheral zone tissue in a human prostate. In one method, a needle is introduced into peripheral zone tissue of a human prostate, and vapor media is delivered through the needle to ablate peripheral zone tissue without ablating non-peripheral zone tissue. Systems for treating prostate cancer with vapor therapy are also provided. 1. A method for treating abnormal prostate tissue , comprising:introducing a vapor delivery needle into peripheral zone tissue of a human prostate; anddelivering condensable vapor through the needle to ablate peripheral zone tissue without ablating non-peripheral zone tissue.2. The method of wherein the introducing step includes introducing the needle into peripheral zone tissue within first and second prostate lobes.3. The method of wherein the introducing step includes positioning the needle in a plurality of locations in the peripheral zone tissue prior to delivering condensable vapor.4. The method of wherein the peripheral zone tissue includes malignant tissue.5. The method of wherein the introducing step includes introducing the needle in at least one of a perineal approach claim 1 , trans-rectal approach or trans-urethral approach.6. The method of wherein the introducing step includes positioning the needle under imaging guidance.7. The method of wherein the imaging guidance is ultrasound.8. The method of wherein the condensable vapor includes water vapor.9. The method of wherein the delivering step includes vaporizing a flow of fluid having a flow rate ranging from 1 cc/min to 60 cc/min to thereby provide the condensable vapor.10. The method of wherein the delivering step includes delivering condensable vapor configured for focal ablation of abnormal tissue.11. The method of wherein the condensable vapor is delivered for between 2 seconds and 20 seconds each ...

Lubricant Compositions Comprising Boroxines and Sterically Hindered Amines To Improve Fluoropolymer Seal Compatibility

A lubricant composition including a boroxine compound is disclosed. A lubricant composition and additive package including a boroxine compound and a sterically hindered amine compound are also disclosed. A method of lubricating a system comprising a fluoropolymer seal with the lubricant composition is also disclosed. The boroxine compound of the lubricant composition acts to improve compatibility of the lubricant composition with a fluoropolymer seal. 2. The lubricant composition of wherein each Ris independently an alkyl group having from 1 to 5 carbon atoms.3. The lubricant composition of wherein said boroxine compound is included in an amount ranging from 0.1 to 5 wt. % based on said total weight of said lubricant composition.4. The lubricant composition of wherein at least 50 wt. % of said boroxine compound remains unreacted in said lubricant composition based on a total weight of said boroxine compound utilized to form said lubricant composition prior to any reaction in said lubricant composition.5. The lubricant composition of wherein said sterically hindered amine compound comprises at least one piperidine ring and at least one ester group.7. The lubricant composition of wherein said sterically hindered amine compound is (2 claim 1 ,2 claim 1 ,6 claim 1 ,6-tetramethyl-4-piperidyl)dodecanoate.8. The lubricant composition of wherein said sterically hindered amine compound has a total base number of at least 70 mg KOH/g when tested according to ASTM D4739.9. The lubricant composition of wherein said base oil has a viscosity ranging from 1 to 20 cSt when tested at 100° C. according to ASTM D445 and is selected from the group of API group I oils claim 1 , API group II oils claim 1 , API group III oils claim 1 , API group IV oils claim 1 , API group V oils claim 1 , and combinations thereof.10. The lubricant composition of further comprising a dispersant.11. The lubricant composition of wherein said dispersant is included in said lubricant composition in an amount ...

Lubricant Compositions Comprising Boroxines and Amine Compounds To Improve Fluoropolymer Seal Compatibility

A lubricant composition including a boroxine compound is disclosed. A lubricant composition and additive package including a boroxine compound and an amine compound are also disclosed. A method of lubricating a system comprising a fluoropolymer seal with the lubricant composition is also disclosed. The boroxine compound of the lubricant composition acts to improve compatibility of the lubricant composition with a fluoropolymer seal. 2. The lubricant composition of wherein each Ris independently an alkyl group having from 1 to 5 carbon atoms.3. The lubricant composition of wherein said boroxine compound is included in an amount ranging from 0.1 to 5 wt. % based on a total weight of said lubricant composition.4. The lubricant composition of wherein at least 50 wt. % of said boroxine compound remains unreacted in said lubricant composition based on a total weight of said boroxine compound utilized to form said lubricant composition prior to any reaction in said lubricant composition.5. The lubricant composition of wherein said amine compound is included in an amount ranging from 0.1 to 20 wt. % based on a total weight of said lubricant composition.6. The lubricant composition of wherein said amine compound comprises at least one piperidine ring and at least one ester group.7. The lubricant composition of wherein said amine compound is (2 claim 1 ,2 claim 1 ,6 claim 1 ,6-tetramethyl-4-piperidyl)dodecanoate.8. The lubricant composition of wherein said amine compound consists essentially of hydrogen claim 1 , carbon claim 1 , nitrogen claim 1 , and oxygen or wherein said amine compound consists essentially of hydrogen claim 1 , carbon claim 1 , and nitrogen.9. The lubricant composition of wherein said lubricant composition is free of a phosphate amine salt.10. The lubricant composition of wherein said base oil has a viscosity ranging from 1 to 20 cSt when tested at 100° C. according to ASTM D445 and is selected from the group of API group I oils claim 1 , API group II ...

INDUCTION COIL VAPOR GENERATOR

An induction coil vapor generator is provided that may include any of a number of features. One feature of the vapor generator is that it can inductively generate high quality condensable vapor. The vapor generator can comprise an outer assembly that supports a coil wire, and an inner assembly disposed in the outer assembly. The inner assembly can house a plurality of micro-tubes configured to be inductively heated by the coil wire to convert a fluid to condensable vapor. The generator can be disposed in a medical device to treat tissue with vapor. One feature of the medical device is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. Methods associated with use of the vapor generator are also covered. 1. An inductive vapor generator , comprising:an outer support assembly;a coil disposed around the outer support assembly;an inner assembly disposed within the outer support assembly;a plurality of microtubes disposed within the inner assembly, the microtubes being configured to receive a fluid from a fluid source; anda RF generator electrically coupled to the coil, the RF generator being configured to apply a current to the coil to inductively heat fluid in the plurality of microtubes to convert the fluid into a heated condensable vapor.2. The generator of wherein the outer support assembly comprises a thermally insulating and electrically insulating tube.3. The generator of wherein the inner assembly comprises a thermally conductive and electrically insulating tube.4. The generator of further comprising an air gap between the outer support assembly and the inner assembly.5. The generator of wherein the plurality of microtubes comprises stainless steel microtubes.6. The generator of wherein the inner assembly comprises a solid metal rod and the plurality of microtubes comprises an array of channels drilled through the solid metal rod.7. The generator of wherein the outer support assembly has a length ...

SYSTEMS AND METHODS FOR TREATMENT OF BPH

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe from the urethra. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Another feature of the prostate therapy system is that it can aspirate tissue from the prostate. Yet another feature of the prostate therapy system is that it can rotate during delivery of vapor and aspiration of tissue. Methods associated with use of the prostate therapy system are also covered. 1. A method of treating a patient's prostate comprising:introducing a vapor energy delivery system into a urethra of the patient;rotating the vapor energy delivery system within the urethra;delivering a flow of fluid through at least one hypotube of the vapor energy delivery system;inductively heating the at least one hypotube to generate a condensable vapor from the flow of fluid; anddelivering the condensable vapor from the vapor energy delivery system to the patient's prostate.2. The method of further comprising injecting high pressure liquid from the tissue extraction member into the urethra.3. The method of wherein the step of injecting high pressure liquid comprises injecting high pressure liquid in pulses between 1 pulse/second and 100 pulses/second.4. The method of wherein the step of injecting high pressure liquid comprises injecting high pressure liquid radially outward from a longitudinal axis of the tissue extraction member.5. The method of wherein the step of injecting high pressure liquid comprises injecting high pressure liquid at an angle of between 10 degrees and 90 degrees from a longitudinal axis of the tissue extraction member.6. The method of further comprising expanding an occlusion member within the urethra distal to a tissue extraction member vapor exit port prior to the delivering step.7. The method of further comprising expanding an ...

MEDICAL SYSTEM AND METHOD OF USE

Methods, systems and devices for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure. 1. A method for a controlled ablation of a targeted tissue , the method comprising:providing a medical system comprising a handle coupled to a catheter having an elongate shape, the catheter having a working end, a flow channel extending through the medical system and through the working end, a pump configured to cause a flow of a liquid media in the flow channel, at least one helical element around a portion of the flow channel, an electrical source coupled to the at least one helical element such that delivery of an energy from the electrical source to the at least one helical element converts the flow of the liquid media into a flow of a vapor media, and a controller configured to control the pump and the energy;introducing the catheter through a body lumen;using an imaging system to position the working end at a selected location in the body lumen and to advance a needle outward from the working end into the targeted tissue;operating the controller to provide a selected flow rate of the flow of the liquid media and to apply a selected level of the energy to convert the flow of the liquid media into the flow of the vapor media at the selected flow rate, such that the flow of the vapor media provides a controlled amount of energy; anddelivering the flow of the vapor media through the needle into the targeted tissue for a selected time interval to ablate the targeted tissue.2. The method of wherein introducing the catheter comprises introducing the catheter over a guidewire.3. The method of wherein the working end carries radiopaque markings for observing with the imaging system.4. The method of wherein the controller includes a user interface configured with user-selectable settings for at least ...

LUBRICANT COMPOSITIONS COMPRISING EPOXIDE COMPOUNDS

A lubricant composition including an epoxide compound is disclosed. An additive package including the epoxide compound is also disclosed. The epoxide compound of the lubricant composition acts to improve compatibility of the lubricant composition with a fluoropolymer seal and improve the total base number of the lubricant composition. 2. The lubricant composition of wherein said epoxide compound is a polyepoxide compound including at least two oxirane rings per molecule of the polyepoxide compound.4. The lubricant composition of wherein said epoxide compound is included in an amount of from 0.05 to 5 wt. % based on a total weight of said lubricant composition.5. The lubricant composition of wherein said epoxide compound has a weight average molecular weight of from 30 to 1500.6. The lubricant composition of wherein said epoxide compound has a boiling point of from 50 to 450° C. at 1 atmosphere of pressure.7. The lubricant composition of wherein said epoxide compound has a flash point of from 25 to 250° C. at 1 atmosphere of pressure.8. The lubricant composition of wherein at least 50 wt. % of said epoxide compound remains unreacted in said lubricant composition based on a total weight of said epoxide compound utilized to form said lubricant composition prior to any reaction in said lubricant composition.9. The lubricant composition of wherein said lubricant composition is a crankcase lubricant composition.10. (canceled)11. The lubricant composition of wherein said sterically hindered amine compound is included in an amount of from 0.1 to 10 wt. % based on a total weight of said lubricant composition.12. The lubricant composition of wherein said sterically hindered amine compound is (2 claim 11 ,2 claim 11 ,6 claim 11 ,6-tetramethyl-4-piperidyl) dodecanoate.13. The lubricant composition of further comprising an antiwear additive comprising phosphorous.14. The lubricant composition of wherein said antiwear additive comprising phosphorous is included in said lubricant ...

Lubricant Compositions Comprising Trimethoxyboroxine To Improve Fluoropolymer Seal Compatibility

A lubricant composition including a boroxine compound is disclosed. An additive package including the boroxine compound is also disclosed. The boroxine compound of the lubricant composition acts to improve compatibility of the lubricant composition with a fluoropolymer seal. 2. The lubricant composition of wherein said boroxine compound is included in an amount ranging from 0.1 to 5 wt. % based on a total weight of said lubricant composition.3. The lubricant composition of wherein at least 50 wt. % of said boroxine compound remains unreacted in said lubricant composition based on a total weight of said boroxine compound utilized to form said lubricant composition prior to any reaction in said lubricant composition.4. The lubricant composition of wherein said lubricant composition comprises less than 0.1 wt. % of acids claim 1 , anhydrides claim 1 , triazoles claim 1 , oxides claim 1 , or combinations thereof claim 1 , based on a total weight of said lubricant composition.5. The lubricant composition of wherein said dihydrocarbyldithiophosphate salt comprises a zinc dihydrocarbyldithiophosphate salt.6. The lubricant composition of wherein said dihydrocarbyldithiophosphate salt is included in said lubricant composition in an amount ranging from 0.1 to 10 wt. % based on a total weight of said lubricant composition.7. The lubricant composition of further comprising a sterically hindered amine compound having a total base number of at least 70 mg KOH/g when tested according to ASTM D4739.9. The lubricant composition of wherein said sterically hindered amine compound is included in an amount ranging from 0.5 to 5 wt. % based on a total weight of said lubricant composition.10. The lubricant composition of wherein said sterically hindered amine compound is (2 claim 7 ,2 claim 7 ,6 claim 7 ,6-tetramethyl-4-piperidyl)dodecanoate.11. The lubricant composition of wherein said base oil has a viscosity ranging from 1 to 20 cSt when tested at 100° C. according to ASTM D445 and is ...

Lubricant Compositions Comprising Trimethoxyboroxines and Amine Compounds To Improve Fluoropolymer Seal Compatibility

A lubricant composition including a boroxine compound is disclosed. An additive package including the boroxine compound is also disclosed. The lubricant composition and the additive package may additionally include an amine compound. The boroxine compound of the lubricant composition acts to improve compatibility of the lubricant composition with a fluoropolymer seal. 2. The lubricant composition of wherein said boroxine compound is included in an amount ranging from 0.1 to 5 wt. % based on a total weight of said lubricant composition.3. The lubricant composition of wherein at least 50 wt. % of said boroxine compound remains unreacted in said lubricant composition based on a total weight of said boroxine compound utilized to form said lubricant composition prior to any reaction in said lubricant composition.4. The lubricant composition of wherein said amine compound is included in an amount ranging from 0.1 to 20 wt. % based on a total weight of said lubricant composition.5. The lubricant composition of wherein said amine compound comprises at least one piperidine ring and at least one ester group.6. The lubricant composition of wherein said amine compound is (2 claim 1 ,2 claim 1 ,6 claim 1 ,6-tetramethyl-4-piperidyl) dodecanoate.7. The lubricant composition of wherein said amine compound consists essentially of hydrogen claim 1 , carbon claim 1 , nitrogen claim 1 , and oxygen or wherein said amine compound consists essentially of hydrogen claim 1 , carbon claim 1 , and nitrogen.8. The lubricant composition of wherein said lubricant composition is free of a phosphate amine salt.9. The lubricant composition of wherein said base oil has a viscosity ranging from 1 to 20 cSt when tested at 100° C. according to ASTM D445 and is selected from the group of API group I oils claim 1 , API group II oils claim 1 , API group III oils claim 1 , API group IV oils claim 1 , API group V oils claim 1 , and combinations thereof.10. The lubricant composition of further comprising a ...

MEDICAL SYSTEM AND METHOD OF USE

An instrument and method for applying thermal energy to targeted tissue. An instrument and method for tissue thermotherapy. In one embodiment, a method includes providing a vapor source comprising a pump configured for providing a flow of liquid media from a liquid media source into a vaporization chamber having a heating mechanism, actuating the pump to provide the liquid into the vaporization chamber, applying energy from the heating mechanism to convert a substantially water liquid media into a minimum water vapor level for causing an intended effect in tissue. For examples such levels can comprise at least 60% water vapor, at least 70% water vapor, at least 80% water vapor or at least 90% water vapor for causing an intended effect in tissue. 1. (canceled)2. A method of ablating an endometrium of a uterus , the method comprising:inserting a probe working end through a cervix into the uterus, the probe comprising a delivery lumen, an exit port, and a balloon disposed proximal to the exit port;expanding the balloon such that the balloon prevents retrograde flow from the uterus; delivering a pharmacological agent to the uterus;', 'delivering vapor media from a vapor source to the uterus while controlling a pressure within the uterus; and', 'condensing the vapor media to thereby release heat of vaporization to ablate at least portions of the endometrium., 'after expanding the balloon3. The method of claim 2 , wherein delivering the pharmacological agent to the uterus comprises delivering the pharmacological agent from a pharmacological agent source through the delivery lumen.4. The method of claim 2 , wherein the pharmacological agent is delivered to the uterus before delivering the vapor media to the uterus.5. The method of claim 2 , wherein the pharmacological agent and the vapor media are delivered to the uterus simultaneously.6. The method of claim 5 , wherein the pharmacological agent is mixed with the vapor media.7. The method of claim 2 , wherein ...

SYSTEMS AND METHODS FOR TREATMENT OF PROSTATIC TISSUE

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Methods associated with use of the prostate therapy system are also covered. 1. A method of treating a disorder of a prostate adjacent a prostatic urethra , the method comprising:advancing a vapor ablation probe transurethrally into the prostate;delivering condensable vapor into the prostate, the condensable vapor undergoing a phase change to deliver energy to the prostate; andablating prostate tissue without ablating the prostatic urethra.2. The method of wherein the advancing step comprises advancing the vapor ablation probe into an apex of a lobe of the prostate.3. The method of wherein the condensable vapor delivers between 100 W and 400 W to the prostate.4. The method of wherein the condensable vapor delivers between 250 cal/gm and 450 cal/gm to the prostate.5. The method of wherein the condensable vapor delivers between 20 W and 100 W to the prostate.6. The method of wherein the condensable vapor delivers between 100 cal/gm and 600 cal/gm to the prostate.7. The method of wherein the introducing step comprises advancing the ablation probe at least 15 mm into the prostate.8. The method of wherein the introducing step comprises introducing condensable vapor into the prostate through a plurality of vapor ports in the ablation probe.9. The method of wherein the introducing step comprises orienting the vapor ports toward the urethra.10. The method of wherein the introducing step comprises advancing an introducer into a urethra and advancing the ablation probe through the introducer.11. The method of further comprising placing a port of the introducer against a urethral wall prior to advancing the ablation probe through the introducer.12. The method of ...

LUBRICANT COMPOSITION

A lubricant composition has an increased oxidation induction time. The lubricant composition includes a base oil present in an amount of greater than 85 parts by weight per 100 parts by weight of the lubricant composition. The lubricant composition also includes an antioxidant component including particular first, second, and third antioxidants. 2. The lubricant composition of wherein said first claim 1 , second claim 1 , and third antioxidants are present in a ratio of from 0.1:0.1:0.1 to 3:5:5.3. The lubricant composition of wherein R is a straight or branched alkyl group of 11 or 17 carbon atoms.4. The lubricant composition of wherein R is a straight or branched alkyl group of 8 to 14 carbon atoms.5. The lubricant composition of wherein R is a straight or branched alkyl group of 10 to 14 carbon atoms.6. The lubricant composition of wherein R is a straight or branched alkyl group of 10 to 12 carbon atoms.7. The lubricant composition of wherein R is a straight or branched alkyl group of 11 atoms.14. The lubricant composition of wherein said base oil is further defined as an API Group II claim 1 , Group III or Group IV oil.15. The lubricant composition of having an oxidation induction time of greater than 10 minutes determined according to ASTM D6186.16. The lubricant composition of having an oxidation induction time of greater than 12 minutes determined according to ASTM D6186.18. A method of forming the lubricant composition of wherein the method comprises the step of combining the base oil and the antioxidant component to form the lubricant composition. The present disclosure generally relates to a lubricant composition that has an increased oxidation induction time and that includes a base oil and an antioxidant component. More specifically, the antioxidant component includes three particular antioxidants.Lubricant compositions are generally well known in the art and are typically categorized as engine oils, driveline system oils, gear oils, greases, automatic ...

Lubricant Compositions Comprising Epoxide Compounds

A lubricant composition including an epoxide compound is disclosed. An additive package including the epoxide compound is also disclosed. The epoxide compound of the lubricant composition acts to improve compatibility of the lubricant composition with a fluoropolymer seal and improve the total base number of the lubricant composition. 1. A lubricant composition comprising:a base oil; 'an epoxide compound having two or more oxirane rings,', 'an additive package comprising 'an antiwear additive comprising phosphorous,', 'wherein at least one of said oxirane rings is terminal; and'}wherein said additive package is present in an amount of at least 5 wt. % based on a total weight of said lubricant composition.2. The lubricant composition of wherein said epoxide compound is monomeric.5. The lubricant composition of wherein said epoxide compound includes fewer than five oxirane rings per molecule of said epoxide compound.6. The lubricant composition of wherein said epoxide compound is included in an amount of from 0.1 to 5 wt. % based on a total weight of said lubricant composition.7. The lubricant composition of wherein said epoxide compound has a weight average molecular weight of from 30 to 1500.8. The lubricant composition of wherein said epoxide compound has an epoxide equivalent weight of from 75 to 250 g per mole of oxirane ring in said epoxide compound.9. The lubricant composition of wherein said epoxide compound has a boiling point of at least 50° C. at 1 atmosphere of pressure.10. The lubricant composition of wherein said epoxide compound has a flash point of at least 25° C. at 1 atmosphere of pressure.11. The lubricant composition of wherein at least 50 wt. % of said epoxide compound remains unreacted in said lubricant composition based on a total weight of said epoxide compound utilized to form said lubricant composition prior to any reaction in said lubricant composition.12. The lubricant composition of wherein said lubricant composition is a crankcase ...

Lubricant Compositions Comprising Epoxide Compounds

A lubricant composition including an epoxide compound is disclosed. An additive package including the epoxide compound is also disclosed. The epoxide compound of the lubricant composition acts to improve compatibility of the lubricant composition with a fluoropolymer seal and improve the total base number of the lubricant composition. 1. A lubricant composition comprising:a base oil; 'wherein each carbon of each of at least two of the oxirane rings is part of a cyclic hydrocarbon ring, and', 'a cycloaliphatic epoxide compound having two or more oxirane rings,'}, 'an additive package comprising said lubricant composition includes less than 1500 ppm phosphorous as measured according to ASTM D5185;', 'said lubricant composition includes less than 20 wt. % of a carboxylic acid ester based on a total weight of said lubricant composition; and', 'said additive package is present in an amount of at least 5 wt. % based on a total weight of said lubricant composition., 'wherein2. The lubricant composition of wherein said cycloaliphatic epoxide compound is monomeric.5. The lubricant composition of wherein said cycloaliphatic epoxide compound includes fewer than five oxirane rings per molecule of said epoxide compound.6. The lubricant composition of wherein said cycloaliphatic epoxide compound is included in an amount of from 0.1 to 5 wt. % based on a total weight of said lubricant composition.7. The lubricant composition of wherein said cycloaliphatic epoxide compound has a weight average molecular weight of from 30 to 1500.8. The lubricant composition of wherein said cycloaliphatic epoxide compound has an epoxide equivalent weight of from 75 to 250 g per mole of oxirane ring in said epoxide compound.9. The lubricant composition of wherein said cycloaliphatic epoxide compound has a boiling point of at least 50° C. at 1 atmosphere of pressure.10. The lubricant composition of wherein said cycloaliphatic epoxide compound has a flash point of at least 25° C. at 1 atmosphere of ...

Lubricant Compositions Comprising Epoxide Compounds

A lubricant composition including an epoxide compound is disclosed. An additive package including the epoxide compound is also disclosed. The epoxide compound of the lubricant composition acts to improve compatibility of the lubricant composition with a fluoropolymer seal and improve the total base number of the lubricant composition. 2. The lubricant composition of wherein said epoxide compound is a polyepoxide compound including at least two oxirane rings per molecule of the polyepoxide compound.4. The lubricant composition of wherein said epoxide compound is included in an amount of from 0.05 to 5 wt. % based on a total weight of said lubricant composition.5. The lubricant composition of wherein said epoxide compound has a weight average molecular weight of from 30 to 1500.6. The lubricant composition of wherein said epoxide compound has a boiling point of from 50 to 450° C. at 1 atmosphere of pressure.7. The lubricant composition of wherein said epoxide compound has a flash point of from 25 to 250° C. at 1 atmosphere of pressure.8. The lubricant composition of wherein at least 50 wt. % of said epoxide compound remains unreacted in said lubricant composition based on a total weight of said epoxide compound utilized to form said lubricant composition prior to any reaction in said lubricant composition.9. The lubricant composition of wherein said lubricant composition is a crankcase lubricant composition.10. The lubricant composition of wherein said base oil is selected from the group consisting of API group I oils claim 1 , API group II oils claim 1 , API group III oils claim 1 , API group IV oils claim 1 , API group V oils claim 1 , and combinations thereof.11. The lubricant composition of wherein said sterically hindered amine compound is included in an amount of from 0.1 to 10 wt. % based on a total weight of said lubricant composition.12. The lubricant composition of wherein said sterically hindered amine compound is (2 claim 11 ,2 claim 11 ,6 claim 11 ,6- ...

Lubricant Compositions Comprising Epoxide Compounds

A lubricant composition including an epoxide compound is disclosed. An additive package including the epoxide compound is also disclosed. The epoxide compound of the lubricant composition acts to improve compatibility of the lubricant composition with a fluoropolymer seal and improve the total base number of the lubricant composition. 1. A lubricant composition comprising:a base oil; an epoxide compound, and', 'an amine compound having a total base number of at least 80 mg KOH/g when tested according to ASTM D4739;, 'an additive package comprisingwherein said additive package is present in an amount of at least 5 wt. % based on a total weight of said lubricant composition; andwherein said lubricant composition includes less than 5 wt. % of an estolide compound based on a total weight of said lubricant composition.2. The lubricant composition of wherein said epoxide compound is monomeric.3. The lubricant composition of wherein said epoxide compound is a polyepoxide compound that includes at least two oxirane rings per molecule of said polyepoxide compound.6. The lubricant composition of wherein said polyepoxide compound includes fewer than 5 oxirane rings per molecule of said polyepoxide compound.7. The lubricant composition of wherein said epoxide compound is included in an amount of from 0.1 to 5 wt. % based on a total weight of said lubricant composition.8. The lubricant composition of wherein said epoxide compound has a weight average molecular weight of from 30 to 1500.9. The lubricant composition of wherein said epoxide compound has an epoxide equivalent weight of from 75 to 250 g per mole of oxirane ring in said epoxide compound.10. The lubricant composition of wherein said epoxide compound has a boiling point of at least 50° C. at 1 atmosphere of pressure.11. The lubricant composition of wherein said epoxide compound has a flash point of at least 25° C. at 1 atmosphere of pressure.12. The lubricant composition of wherein at least 50 wt. % of said epoxide ...

SYSTEMS AND METHODS FOR PROSTATE TREATMENT

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the needle can ablate a continuous lobe region in the prostate parallel to the urethral wall. Another feature of the vapor delivery needle is that it can introduce a cooling fluid into the urethra during treatment. Methods associated with use of the energy delivery probe are also covered. 1. A method for treating benign prostatic hyperplasia (BPH) , comprising the steps of:positioning an energy-emitting section of a needle in a plurality of locations in a prostate lobe adjacent the prostatic urethra; anddelivering energy at each location for less than 30 seconds to thereby confine thermal ablation to lobe tissue adjacent the prostatic urethra and preventing thermal diffusion to peripheral lobe tissue.2. The method of wherein the delivering energy step further comprises delivering a condensable vapor media at each location.3. The method of further comprising inserting the energy-emitting section of the needle through a urethral wall into the prostate lobe.4. The method of wherein the inserting step comprises inserting a tip of the energy-emitting section of the needle 15 mm or less through the urethral wall into the prostate lobe.5. The method of wherein the delivering energy step comprises confining thermal ablation to a continuous lobe region extending less than 2 cm away from the urethral wall.6. The method of further comprising introducing a cooling fluid into a urethra during the delivering energy step.7. The method of further comprising inserting a vapor delivery tool shaft into the urethra claim 6 , the needle being at least partially disposed within the shaft claim 6 , the cooling fluid being introduced into the urethra through the shaft.8. The method of further comprising introducing the cooling ...

MEDICAL SYSTEM AND METHOD OF USE

Methods, systems and devices for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure. 1positioning a working end of a vapor delivery system at a targeted site in a body;providing a flow of liquid media at a selected fluid flow rate in the system and converting the liquid media to vapor media where a vapor flow rate corresponds to the selected fluid flow rate; anddelivering the vapor media to the targeted site for a selected time interval thereby providing a controlled amount of energy to the targeted site.. A method for a controlled treatment of a body structure, the method comprising: This application is a continuation of U.S. patent application Ser. No. 15/912,332 filed Mar. 5, 2018, which is a continuation of U.S. patent application Ser. No. 13/842,632 filed Mar. 15, 2013; and is also a continuation of U.S. patent application Ser. No. 12/856,339 filed Aug. 13, 2010, the contents of each of which are incorporated herein by reference it its entirety.This invention relates to medical instruments and systems for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure.Various types of medical instruments utilizing radiofrequency (RF) energy, laser energy, microwave energy and the like have been developed for delivering thermal energy to tissue, for example to ablate tissue. While such prior art forms of energy delivery work well for some applications, RF, laser and microwave energy typically cannot cause highly “controlled” and “localized” thermal effects that are desirable in controlled ablation soft tissue for ablating a controlled depth or for the creation of precise lesions in such tissue. In general, ...

Lubricant composition

Disclosed herein is a process for lubricating an internal combustion engine with a lubricant composition that may be substantially ash free. The ashless lubricant composition described herein may comprise primary antioxidants, such as aminic diphenyl amines, alkylated phenyl-naphthyl amines, and phenolic antioxidants. The ashless lubricant composition described herein may also comprise sulfur containing products that may work as secondary antioxidants. Other components such as ashless antiwear components, dispersants, pour point depressants, friction modifiers, and metal deactivators may also be used to formulate an ashless lubricant composition according to an embodiment.

ALKOXYLATED AMIDES, ESTERS, AND ANTI-WEAR AGENTS IN LUBRICANT COMPOSITIONS AND RACING OIL COMPOSITIONS

A lubricant composition includes a base oil, an alkoxylated amide, an ester, and an anti-wear agent including phosphorus. The alkoxylated amide and ester have general formulas (I) and (II), respectively. The lubricant composition may be further defined as a racing oil composition. Also disclosed is a method for maximizing the effectiveness of a friction modifier in a racing oil composition thus increasing the fuel economy of a racing vehicle. The method includes providing the racing oil composition and lubricating an internal combustion engine of a racing vehicle to increase the fuel economy of the racing vehicle. 2. The lubricant composition of wherein said lubricant composition is further defined as a racing oil composition.3. The lubricant composition of wherein said anti-wear agent is a zinc dialkyl dithiophosphate.4. The lubricant composition of wherein said anti-wear agent is present in an amount of from 0.01 to 5 wt. % based on the total weight of the lubricant composition.5. The lubricant composition of wherein at least one of Rand Rof said alkoxylated amide comprises a propoxy group.9. The lubricant composition of wherein Rof said alkoxylated amide and said ester are each claim 1 , independently claim 1 , a linear or branched claim 1 , saturated or unsaturated claim 1 , C-Caliphatic hydrocarbyl group.11. The lubricant composition of wherein:{'sup': '1', 'sub': 6', '23, 'each Ris, independently, a linear or branched, saturated or unsaturated, C-Caliphatic hydrocarbyl group;'}{'sup': '5', 'each Ris, independently, an ethyl group or a propyl group;'}{'sup': '6', 'each Ris, independently, a propoxy group;'}n is an integer from 0 to 5;m is an integer from 0 to 5;1≦(n+m)≦5;q is an integer from 0 to 5;if q is 0, p is an integer from 1 to 5;if q is >0, p is an integer from 1 to 5;1≦(p+q)≦5; andsaid lubricant composition comprises said alkoxylated amide and said ester in a weight ratio of less than 70:30 of said ester to said alkoxylated amide.12. The lubricant ...

TUNED RF ENERGY AND ELECTRICAL TISSUE CHARACTERIZATION FOR SELECTIVE TREATMENT OF TARGET TISSUES

A catheter and catheter system can use energy tailored for remodeling and/or removal of target material along a body lumen, often of atherosclerotic material of a blood vessel of a patient. An elongate flexible catheter body with a radially expandable structure may have a plurality of electrodes or other electrosurgical energy delivery surfaces to radially engage atherosclerotic material when the structure expands. An atherosclerotic material detector system may measure and/or characterize the atherosclerotic material and its location, optionally using impedance monitoring. 1. An apparatus for renal neuromodulation , the apparatus comprising:a catheter configured for intravascular placement within a renal blood vessel of a human patient;an expandable balloon at a distal portion of the catheter, wherein the expandable balloon is configured to vary between a delivery configuration and a deployed configuration sized to fit within the renal blood vessel;a first electrode having a first pair of bipolar contacts attached to the expandable balloon; anda second electrode having a second pair of bipolar contacts attached to the expandable balloon,wherein the first electrode and the second electrode are spaced apart lengthwise and angularly offset from one another when the expandable balloon is in the deployed configuration,wherein each of the first electrode and the second electrode is configured to deliver thermal energy to less than a full circumference of the renal blood vessel of the patient.2. The apparatus of wherein:the first electrode is configured to deliver thermal energy to create a first non-continuous, circumferential treatment zone along a lengthwise segment of the renal blood vessel; andthe second electrode is configured to deliver thermal energy to create a second non-continuous, circumferential treatment zone along the lengthwise segment of the renal blood vessel,wherein the first circumferential treatment zone and the second circumferential treatment zone ...

POLYMER FOR LUBRICANT COMPOSITIONS AND METHOD OF FORMING THE SAME

A polymer comprises a polymeric backbone, at least one piperidine ester moiety extending from the polymeric backbone, and generally at least one Cto Cester moiety extending from the polymeric backbone. The polymer is useful for adjusting the total base number and viscosity index of a lubricant composition. The lubricant composition generally comprises a base oil in addition to the polymer. A method of forming the polymer comprises the steps of providing a first component and providing a second component. The first component comprises at least one of A1) a piperidine methacrylate, or A2) a methacrylate. The second component comprises at least one of B) a Cto Cmethacrylate. Optionally, the method further comprises the step of providing a third component, which comprises at least one of C) a piperidine-ol. The method further comprises at least one reaction step involving the aforementioned components to form the polymer. 120-. (canceled)21. A method of forming a polymer for adjusting the total base number (TBN) and viscosity index (VI) of a lubricant composition , said method comprising the steps of: A1) a piperidine methacrylate, or', 'A2) a methacrylate different from the piperidine methacrylate A1);, 'providing a first component comprising at least one of'} {'sub': 8', '22, 'B) a Cto Cmethacrylate;'}, 'providing a second component different from the first component and comprising'} 'C) a piperidine-ol; and', 'optionally, providing a third component comprising'}i) reacting the piperidine methacrylate A1) with the second component B) to form the polymer, wherein A1) and B) are reacted in a molar ratio (A1:B) of from about 15:85 to 25:75; and/orii) reacting the methacrylate A2) with the second component B) to form a reaction intermediate and reacting the reaction intermediate with the third component to form the polymer.22. The method as set forth in claim 21 , wherein the first component comprises the piperidine methacrylate A1) and wherein the piperidine methacrylate ...

METHODS FOR DELIVERING ENERGY INTO A TARGET TISSUE OF A BODY

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery. 1advancing a working end of a device into the body region;expanding a structure from within a working end of the device into the body region, where at least a portion of the thin wall structure is permeable to allow transfer of a medium through the structure to the tissue; anddelivering an amount of energy from the structure to treat the target tissue of the body region wherein delivering the amount of energy comprises delivering energy using a vapor media by passing the vapor media through the structure.. A method of delivering energy into a target tissue of a body region, the method comprising: This application is a continuation of U.S. patent application Ser. No. 14/223,912 filed Mar. 24, 2014, which is a continuation of U.S. patent application Ser. No. 12/555,635 filed Sep. 8, 2009 (now U.S. Pat. No. 8,721,632 issued May 13, 2014), which claims benefit of U.S. Provisional Application No.: 61/191,459 filed on Sep. 9, 2008, the content of each of which is incorporated herein by reference in its entirety.This invention relates to medical instruments and systems for applying energy to tissue, and more particularly relates to a system for ablating, sealing, welding, coagulating, shrinking or creating lesions in tissue by means of contacting a targeted tissue in a patient with a vapor phase media wherein a subsequent vapor-to-liquid phase change of the media applies thermal energy to the tissue to cause an intended therapeutic effect. Variations of the invention include devices and methods for generating a flow of high quality vapor and monitoring the vapor flow for ...

MEDICAL SYSTEM AND METHOD OF USE

An instrument and method for applying thermal energy to targeted tissue. An instrument and method for tissue thermotherapy. In one embodiment, a method includes providing a vapor source comprising a pump configured for providing a flow of liquid media from a liquid media source into a vaporization chamber having a heating mechanism, actuating the pump to provide the liquid into the vaporization chamber, applying energy from the heating mechanism to convert a substantially water liquid media into a minimum water vapor level for causing an intended effect in tissue. For examples such levels can comprise at least 60% water vapor, at least 70% to water vapor, at least 80% water vapor or at least 90% water vapor for causing an intended effect in tissue. 1. A vapor therapy probe for ablating endometrial tissue in a uterus , comprising:a probe body adapted to deliver a condensable vapor from a vapor source through an inflow channel to the uterus;a vapor exit port in a working end of the probe body; andan expandable structure at the working end of the probe body adapted to be expanded within at least a portion of the uterus.2. The probe of wherein the vapor exit port is at a distal end of the probe body.3. The probe of wherein the expandable structure is disposed proximal to the vapor exit port.4. The probe of wherein the vapor exit port extends through the probe body from the inflow channel.5. The probe of wherein the vapor exit port extends through the expandable structure.6. The probe of further comprising a handle at a proximal end of the probe body.7. The probe of wherein the expandable structure comprises a balloon.8. The probe of wherein the probe further comprises an outflow passage.9. A method of ablating an endometrium of a uterus claim 1 , the method comprising:inserting a probe working end through a cervix into the uterus, the probe comprising an expandable structure;expanding the expandable structure within the uterus;after the expanding step, delivering vapor ...

SYSTEMS AND METHODS FOR TREATING THE PROSTATE

A vapor delivery system and method is provided that is adapted for treating prostate tissue. The vapor delivery system includes a vapor delivery needle configured to deliver condensable vapor energy to tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the prostate tissue. The vapor delivery system is properly positioned by measuring and advancing the system based on a field-of-view of an endoscope or camera disposed within the system. 1. A method for treating a prostate , comprising the steps of:inserting a vapor delivery system into a urethra of a patient;advancing a distal portion of the vapor delivery system to a bladder neck of the patient;viewing the distal portion of the vapor delivery system with a camera disposed on or within the vapor delivery system;measuring a distance from the bladder neck to a first treatment region in a first lobe of the prostate with a field of view of the camera;pulling the distal portion of the vapor delivery system proximally across the field of view of the camera to the first treatment region;deploying a vapor delivery needle from the vapor delivery system into the first treatment region of the first lobe; anddelivering vapor into the first treatment region of the first lobe of the prostate to ablate tissue in the prostate.2. The method of claim 1 , further comprising claim 1 , prior to the measuring step claim 1 , measuring a distance from the bladder neck to a veru of the patient.3. The method of claim 2 , further comprising determining a number of treatments to perform based on the distance from the bladder neck to the veru.4. The method of claim 1 , wherein the delivering step comprises delivering between 160-300 calories of energy into the prostate.5. The method of claim 1 , wherein the measuring step further comprises determining a distance traveled by the vapor delivery system when it is moved across the field of view of the camera.6. The method of claim 1 , further ...

METHODS FOR DELIVERING ENERGY INTO A TARGET TISSUE OF A BODY

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery. 115-. (canceled)16. A method for treating a small intestine to affect an individual , the method comprising:advancing a device to a duodenum in the small intestine, where the device comprises a structure configured to engage a targeted site comprising 360 degrees of a wall of the duodenum;applying a fluid media through the device such that the structure confines a flow of the fluid media to the targeted site causing transfer of a controlled thermal energy to the targeted site on the wall of the duodenum; andmaintaining delivery of the flow of the fluid media for a period of time to ablate a thin layer of the wall of the duodenum.17. The method of claim 16 , further comprising inserting a scope into a stomach of the individual.18. The method of claim 16 , further comprising delivering a cooling fluid to the device to cool a surface of the wall after ablating the thin layer.19. The method of claim 16 , wherein the thin layer of the wall of the small intestine is in a duodenum of the individual.20. The method of claim 16 , wherein the device is configured to apply a heated fluid media to produce the controlled thermal energy.21. The method of claim 20 , where a temperature of the heated fluid media is at least 60 degrees Celsius.22. The method of claim 16 , wherein the period of time ranges from 1 second to 30 seconds.23. The method of claim 16 , further comprising applying the controlled thermal energy sequentially to at least one adjacent region of the wall in the duodenum.24. The method of claim 16 , wherein a source of heated fluid media is remote from the device ...

VAPOR ABLATION SYSTEMS AND METHODS

A vapor delivery device is provided that may include any of a number of features. One feature of the vapor delivery device is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate tissues of the prostate. The vapor delivery device can include a handle portion and a cartridge portion. The cartridge portion can be configured to be inserted into a lumen of the handle portion to align and position a vapor coil of the cartridge portion within a RF coil of the handle portion. Methods associated with use of the energy delivery probe are also covered. 1. A vapor delivery device , comprising:a handle portion having a lumen and an RF coil disposed in the lumen, the RF coil being connectable to a source of RF energy; and ["an elongate shaft adapted for insertion into a patient's urethra,", 'a vapor delivery needle disposed in the elongate shaft,', 'a vapor coil fluidly connected to the vapor delivery needle and to a fluid source,, 'a cartridge portion adapted to be inserted into the lumen of the handle portion, the cartridge portion includingwherein insertion of the cartridge portion into the handle portion aligns and positions the vapor coil within the RF coil.2. The device of claim 1 , wherein application of RF energy to the RF coil inductively generates vapor in the vapor coil when fluid is delivered from the fluid source to the vapor coil.3. The device of claim 2 , wherein the vapor delivery needle is adapted to deliver the vapor to tissue of the patient.4. The device of claim 1 , wherein the cartridge portion further comprises:a first solenoid coil and a second solenoid coil,a needle driver magnet attached to a proximal portion of the vapor delivery needle, the needle driver magnet being slidably disposed within the first solenoid coil when the vapor delivery needle is in a retracted position and slidably disposed within the second solenoid coil when the vapor delivery needle is in an extended position.5. The device of ...

SYSTEMS AND METHODS FOR PROSTATE TREATMENT

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the vapor delivery needle can be advanced a predetermined distance into the prostate by an actuation mechanism. The actuation mechanism can comprise, for example, a spring, or at least one magnet. Methods associated with use of the energy delivery probe are also covered. 1. A prostate treatment device , comprising:an introducer shaft sized and configured for transurethral access into a patient;a vapor generator configured to generate a condensable vapor;a vapor delivery needle in communication with the vapor generator and slidably disposed within the introducer shaft, the vapor delivery needle coupled to at least one magnet; anda magnetic actuator configured to apply magnetic force to the at least one magnet coupled to the vapor delivery needle to move the vapor delivery needle between a retracted position inside the introducer shaft and an extended position at least partially outside of the introducer shaft.2. The device of wherein the magnetic actuator is configured to axially move the at least one needle and the vapor delivery needle toward the extended position from the retracted position at a velocity ranging from 0.1 meter per second to 20.0 meters per second.3. The device of wherein the magnetic actuator is configured to cause a tip portion of the vapor delivery needle to penetrate into prostate tissue when moving toward the extended position from the retracted position.4. The device of wherein the vapor delivery needle is sized and configured to extend into prostate tissue when the introducer shaft is positioned within a urethra of the patient.5. The device of claim 1 , the magnetic actuator comprising a first rotatable block carrying at least one magnet and a second rotatable block carrying at ...

MEDICAL SYSTEM AND METHOD OF USE

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery. 1providing a probe body having a flow channel extending therein to an outlet in a working end;introducing a flow of a liquid media through the flow channel; andapplying energy to the tissue by inductively heating a portion of the probe sufficient to vaporize the flowing media within the flow channel causing pressurized ejection of the media from the outlet to the tissue.. A method for thermally treating tissue comprising: This application is a continuation of U.S. patent application Ser. No. 12/389,808 filed on Feb. 20, 2009, which claims benefit of U.S. Provisional Application Nos.: 61/126,647 filed on May 06, 2008; 61/126,651 filed on May 06, 2008; 61/126,612 filed on May 06, 2008; 61/126,636 filed on May 06, 2008; 61/130,345 filed on May 31, 2008; 61/191,459 filed on Sep. 9, 2008; 61/066,396 filed on Feb. 20, 2008; 61/123,416 filed on Apr. 08, 2008; 61/068,049 filed on Mar. 04, 2008; 61/123,384 filed on Apr. 08, 2008; 61/068,130 filed on Mar. 04, 2008; 61/123,417 filed on Apr. 08, 2008; 61/123,412 filed on Apr. 08, 2008; 61/126,830 filed on May 07, 2008; and 61/126,620 filed on May 06, 2008, the contents of each of which is incorporated herein by reference in its entirety.The systems and methods described herein are also related to U.S. patent application Ser. No. 10/681,625 filed Oct. 7, 2003; U.S. patent application Ser. No. 11/158,930 filed Jun. 22, 2005; U.S. patent application Ser. No. 11/244,329 filed Oct. 5, 2005; and U.S. patent application Ser. No. 11/329,381 filed Jan. 10, 2006.All of the above applications are incorporated herein by this reference and ...

ALKOXYLATED AMIDES, ESTERS, AND ANTI-WEAR AGENTS IN LUBRICANT COMPOSITIONS AND RACING OIL COMPOSITIONS

A lubricant composition includes a base oil, an alkoxylated amide, an ester, and an anti-wear agent including phosphorus. The alkoxylated amide and ester have general formulas (I) and (II), respectively. The lubricant composition may be further defined as a racing oil composition. 120-. (canceled)22. The additive package of claim 21 , wherein said lubricant composition is a racing oil composition.23. The additive package of claim 21 , further comprising an anti-wear agent comprising phosphorus.24. The additive package of claim 23 , wherein the anti-wear agent comprises zinc dialkyl dithiophosphate.25. The additive package of claim 21 , wherein at least one of Rand Rof said alkoxylated amide comprises a propoxy group.29. The additive package of claim 21 , wherein Rof said alkoxylated amide and said ester are each claim 21 , independently claim 21 , linear or branched claim 21 , saturated or unsaturated claim 21 , C-Caliphatic hydrocarbyl group.30. The additive package of claim 29 , wherein Rof said alkoxylated amide or said ester comprises a hydroxyl group.32. The additive package of claim 31 , wherein{'sup': '5', 'each Ris, independently, an ethyl group or a propyl group,'}{'sup': '6', 'each Ris, independently, a propoxy group;'}if q is 0, p is an integer from 1 to 5, andsaid additive package comprises said alkoxylated amide and said ester in a weight ratio ofless than 70:30 of said ester to said alkoxylated amide.33. The additive package of comprising said alkoxylated amide and said ester in a weight ratio of less than 50:50 of said ester to said alkoxylated amide.37. The additive package of claim 36 , further comprising an anti-wear agent comprising phosphorus.38. The additive package of claim 37 , wherein said anti-wear agent comprises zinc dialkyl dithiophosphate.39. The additive package of claim 36 , wherein each Ris claim 36 , independently claim 36 , a linear or branched claim 36 , saturated or unsaturated C-Caliphatic hydrocarbyl group.40. The additive ...

METHODS FOR DELIVERING ENERGY INTO A TARGET TISSUE OF A BODY

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery. 1. A method for treating a tissue region in a small intestines of a patient , the tissue region having a plurality of secretory ducts and receptors , the method comprising: delivering a catheter into a small intestine adjacent to the tissue region , the catheter comprising an elongate shaft having an energy applicator portion configured with a flow pathway that is fluidly coupled to a source of a heated flowable media; andapplying the heated flowable media to the tissue region using the energy applicator portion to create a thin ablation layer of a wall of the small intestine;wherein the thin ablation layer affects the plurality of secretory ducts and receptors to alter hormonal function of the tissue region.2. The method of claim 1 , wherein the tissue region is within a duodenum of the patient.3. The method of claim 1 , wherein the heated flowable media has a temperature of at least 80 degrees Celsius.4. The method of claim 1 , wherein the heated flowable media has a temperature of at least 90 degrees Celsius.5. The method of claim 1 , wherein the heated flowable media is provided over a time interval ranging from 1 second to 30 seconds.6. The method of claim 1 , further comprising applying the heated flowable media sequentially to at least one adjacent tissue region in the small intestine.7. The method of claim 1 , wherein the source of heated flowable media is provided from a remote source and heating mechanism coupled to an inflow channel in the catheter.8. The method of claim 1 , wherein the catheter is configured to circulate movement of the heated flowable ...

MEDICAL SYSTEM AND METHOD OF USE

Methods, systems and devices for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure 1. A method for a controlled treatment of a body structure , the method comprising:positioning a working end of a vapor delivery system at a targeted site in a body;providing a flow of liquid media at a selected fluid flow rate in the system and converting the liquid media to vapor media where a vapor flow rate corresponds to the selected fluid flow rate; anddelivering the vapor media to the targeted site for a selected time interval thereby providing a controlled amount of energy to the targeted site.216.-. (canceled)17. A medical method for treating body structure , comprising:providing a vapor delivery system including a flow channel and energy applicator for applying energy to a flow of liquid media in the flow channel;introducing a first flow of liquid media at a first liquid flow rate into the flow channel and converting the liquid media to vapor media, wherein a first vapor flow rate is configured for at least one of pre-heating and maintaining heat in the flow channel; andintroducing a second flow of liquid media at a second liquid flow rate into the flow channel and converting the liquid media to vapor media, wherein second vapor flow rate is configured for exiting at least one vapor outlet for applying energy to the body structure.18. The medical method of wherein following introducing a first flow of liquid media claim 17 , the method includes positioning a working end of the system into or proximate the body structure claim 17 , wherein the first vapor flow rate is configured to prevent at least one of gas and body fluids from migrating into the least one vapor outlet.19. The medical method of wherein the first liquid flow rate is less than 1.0 ml/min.20. The medical method of wherein ...

Polymer For Lubricant Compositions And Method Of Forming The Same

A polymer comprises a polymeric backbone, at least one piperidine ester moiety extending from the polymeric back-bone, and generally at least one Cto Cester moiety extending from the polymeric backbone. The polymer is useful for adjusting the total base number and viscosity index of a lubricant composition. The lubricant composition generally comprises a base oil in addition to the polymer. A method of forming the polymer comprises the steps of providing a first component and providing a second component. The first component comprises at least one of A1) a piperidine methacrylate, or A2) a methacrylate. The second component comprises at least one of B) a Cto Cmethacrylate. Optionally, the method further comprises the step of providing a third component, which comprises at least one of C) a piperidine-ol. The method further comprises at least one reaction step involving the aforementioned components to form the polymer. 1. A lubricant composition comprising:a base oil; and a polymeric backbone,', 'at least one piperidine ester moiety extending from said polymeric backbone, and', {'sub': 8', '22, 'at least one Cto Cester moiety different from said piperidine ester moiety extending from said polymeric backbone.'}], 'a polymer for adjusting the total base number (TBN) and viscosity index (VI) of said lubricant composition comprising;'}3. The lubricant composition as set forth in wherein Ris a hydrogen or a methyl group (CH) and at least two of the Rgroups are CHin formula (I).4. The lubricant composition as set forth in wherein Ris a hydrogen and each of the Rgroups is a CHin formula (I).6. The lubricant composition as set forth in wherein said polymeric backbone of said polymer comprises:i) the reaction product of monomers selected from the group consisting of ethylene monomers, propylene monomers, butylene monomers, methacrylate monomers, vinyl acetate monomers, and combinations thereof; orii) an ethylene-propylene copolymer, a polyisobutylene, a polymethacrylate, or ...

MEDICAL SYSTEM AND METHOD OF USE

Methods, systems and devices for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure. 1positioning a working end of a vapor delivery system at a targeted site in a body;providing a flow of liquid media at a selected fluid flow rate in the system and converting the liquid media to vapor media where a vapor flow rate corresponds to the selected fluid flow rate; anddelivering the vapor media to the targeted site for a selected time interval thereby providing a controlled amount of energy to the targeted site.. A method for a controlled treatment of a body structure, the method comprising: This application is a continuation of U.S. patent application Ser. No. 13/842,632 filed Mar. 15, 2013; and is also a continuation of U.S. patent application Ser. No. 12/856,339 filed Aug. 13, 2010, the contents of each of which are incorporated herein by reference it its entirety.This invention relates to medical instruments and systems for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure.Various types of medical instruments utilizing radiofrequency (RF) energy, laser energy, microwave energy and the like have been developed for delivering thermal energy to tissue, for example to ablate tissue. While such prior art forms of energy delivery work well for some applications, RF, laser and microwave energy typically cannot cause highly “controlled” and “localized” thermal effects that are desirable in controlled ablation soft tissue for ablating a controlled depth or for the creation of precise lesions in such tissue. In general, the non-linear or non-uniform characteristics of tissue affect electromagnetic energy ...

TRANSPERINEAL VAPOR ABLATION SYSTEMS AND METHODS

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, or denature tissues of the prostate. Methods associated with use of the energy delivery probe are also covered. 1. A method of treating prostate cancer in a patient , comprising:cooling a urethra of the patient with a urethral cooling catheter;cooling tissue adjacent to a prostate of the patient with an injection of chilled fluid;imaging the prostate in real-time;advancing a vapor delivery device trans-perineally into the prostate;inductively generating vapor in the vapor delivery device; anddelivering the vapor to the prostate through the vapor delivery device.2. The method of claim 1 , further comprising measuring a first electrical impedance and phase shift of tissue at a distal tip of the vapor delivery device.3. The method of claim 2 , further comprising determining if the distal tip is inserted into the prostate of the patient based on the measured first electrical impedance and phase shift.4. The method of claim 2 , further comprising measuring a second electrical impedance and phase shift of tissue at a portion of the vapor delivery device proximal to the distal tip.5. The method of claim 4 , further comprising determining if the portion of the vapor delivery device proximal to the distal tip is inserted into the prostate of the patient based on the measured second electrical impedance and phase shift.6. The method of claim 1 , further comprising actively insulating a portion of the vapor delivery device that lies adjacent to perineum tissue of the patient.7. The method of wherein actively insulating comprises forming an insulating air space in a plurality of tubes surrounding an elongate shaft of the vapor delivery device.8. A method of positioning a vapor delivery device in a prostate claim 6 , comprising:advancing a vapor delivery device ...

SYSTEMS AND METHODS FOR PROSTATE TREATMENT

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the vapor delivery needle can be advanced a pre-determined distance into the prostate by an actuation mechanism. The actuation mechanism can comprise, for example, a spring, or at least one magnet. Methods associated with use of the energy delivery probe are also covered. 1. A prostate treatment device , comprising:an introducer shaft sized and configured for transurethral access into a patient;a vapor generator configured to generate a condensable vapor;a vapor delivery needle in communication with the vapor generator and slidably disposed within the introducer shaft; anda magnetic actuator configured to apply magnetic force to the vapor delivery needle to move the vapor delivery needle between a retracted position inside the introducer shaft and an extended position at least partially outside of the introducer shaft.2. The device of wherein the magnetic actuator is configured to axially move the vapor delivery needle toward the extended position from the retracted position at a velocity ranging from 0.1 meter per second to 20.0 meters per second.3. The device of wherein the magnetic actuator is configured to cause a tip portion of the vapor delivery needle to penetrate into prostate tissue when moving toward the extended position from the retracted position.4. The device of wherein the vapor delivery needle is sized and configured to extend into prostate tissue when the introducer shaft is positioned within a urethra of the patient.5. The device of claim 2 , the magnetic actuator further comprising a first magnet carried by the vapor delivery needle claim 2 , wherein the magnetic actuator is configured to move the first magnet and the vapor delivery needle proximally and distally along a longitudinal ...

METHODS FOR DELIVERING ENERGY INTO A TARGET TISSUE OF A BODY

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery. 1advancing a working end of a device into the body region;expanding a structure from within a working end of the device into the body region, where at least a portion of the thin wall structure is permeable to allow transfer of a medium through the structure to the tissue; anddelivering an amount of energy from the structure to treat the target tissue of the body region wherein delivering the amount of energy comprises delivering energy using a vapor media by passing the vapor media through the structure.. A method of delivering energy into a target tissue of a body region, the method comprising: This application is a continuation of U.S. patent application Ser. No. 14/223,912 filed Mar. 24, 2014, which is a continuation of U.S. patent application Ser. No. 12/555,635 filed Sep. 8, 2009 (now U.S. Pat. No. 8,721,632 issued May 13, 2014), which claims benefit of U.S. Provisional Application No.: 61/191,459 filed on Sep. 9, 2008, the content of each of which is incorporated herein by reference in its entirety.This invention relates to medical instruments and systems for applying energy to tissue, and more particularly relates to a system for ablating, sealing, welding, coagulating, shrinking or creating lesions in tissue by means of contacting a targeted tissue in a patient with a vapor phase media wherein a subsequent vapor-to-liquid phase change of the media applies thermal energy to the tissue to cause an intended therapeutic effect. Variations of the invention include devices and methods for generating a flow of high quality vapor and monitoring the vapor flow for ...

SYSTEMS AND METHODS FOR PROSTATE TREATMENT

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the vapor delivery needle can be advanced a predetermined distance into the prostate by an actuation mechanism. The actuation mechanism can comprise, for example, a spring, or at least one magnet. Methods associated with use of the energy delivery probe are also covered. 116-. (canceled)17. A method of treating prostate tissue , comprising:inserting a shaft of a prostate therapy device transurethrally until a working end of the shaft is proximate to the prostate tissue of a patient;actuating a magnetic assembly to advance a vapor delivery needle from a retracted position located within the shaft to an extended position radially outwardly of the shaft and into the prostate tissue;releasing a lock to permit delivery of condensable vapor to tissue of the patient when the vapor delivery needle is in the extended position;delivering condensable vapor from the vapor delivery needle into the prostate tissue to provide a thermal effect in a first region of the prostate tissue; anddelivering condensable vapor from the vapor delivery needle into the prostate tissue to provide a thermal effect in a second region of the prostate tissue;wherein the first region and the second region partially overlap.18. The method of claim 17 , further including:before delivering condensable vapor from the vapor delivery needle into the prostate tissue to provide a thermal effect in the second region of the prostate tissue, moving the vapor delivery needle from the extended position to the retracted position;moving a the working end of the shaft to an second location proximate to the prostate tissue of the patient; andactuating the magnetic assembly to advance the vapor delivery needle from a retracted position to the extended ...

Lubricant Composition Comprising Hindered Cyclic Amines

A lubricant composition includes a base oil and a cyclic amine compound. A method of lubricating a system including a fluoropolymer seal with the lubricant composition is also provided. An additive concentrate for a lubricant composition is also provided. The cyclic amine compound is useful for adjusting the total base number of a lubricant composition. The lubricant composition is compatible with fluoropolymer seals. 110.-. (canceled)1215.-. (canceled)16. A method according to where each Ris an independently selected alkyl group having from 1 to 6 carbon atoms in formula (I) claim 11 ,{'sup': '2', 'where Ris an alkyl group having from 1 to 4 carbon atoms, and'}{'sup': '3', 'where Ris an alkyl group having from 6 to 14 carbon atoms.'}17. A method according to where the cyclic amine compound is present in an amount ranging from 0.1 to 10 wt. % claim 16 , based on a total weight of the lubricant composition.18. A method according to where the lubricant composition further comprises a dispersant claim 17 , an anti-wear additive comprising sulfur and/or phosphorus claim 17 , or combinations thereof.19. A method according to where the base oil is selected from an API Group I Oil claim 18 , an API Group II Oil claim 18 , an API Group III Oil claim 18 , an API Group IV Oil claim 18 , and combinations thereof claim 18 , and where the base oil has a viscosity ranging from 1 to 20 cSt when tested at 100° C. according to ASTM D445.20. A method according to where the cyclic amine compound has a weight average molecular weight ranging from 100 to 1200.21. A method according to where the cyclic amine compound has a total base number value of at least 70 mg KOH per g of the cyclic amine compound when tested according to ASTM D4739.22. A method according to where the system comprises an internal combustion engine.23. A method according to where the cyclic amine compound comprises only one ester group.24. A method according to where the lubricant composition comprises less than 0.1 ...

Lubricant Composition Comprising Acyclic Hindered Amines

A lubricant composition including an acyclic amine compound. A method of lubricating a system including a fluoro-polymer seal with the lubricant composition is also provided. An additive concentrate for a lubricant composition is also provided. The acyclic amine compound is useful for adjusting the total base number of a lubricant composition. The lubricant composition is compatible with fluoropolymer seals. 2. (canceled)3. A crankcase lubricant composition according to wherein said acyclic amine compound is non-polymeric and has a weight average molecular weight ranging from 100 to 1200.4. A crankcase lubricant composition according to where said acyclic amine compound has a weight average molecular weight ranging from 200 to 800.5. A crankcase lubricant composition according to wherein each Ris an independently selected alkyl group having from 1 to 8 carbon atoms.6. A crankcase lubricant composition according to wherein each Ris an independently selected alkyl group having from 1 to 8 carbon atoms.7. A crankcase lubricant composition according to wherein Ris an alkyl group having from 1 to 4 carbon atoms.8. A crankcase lubricant composition according to wherein said acyclic amine compound has a TBN value of at least 70 mg KOH per g of said acyclic amine compound when tested according to ASTM D4739.9. A crankcase lubricant composition according to comprising less than 0.1 wt. % of compounds which would react with said acyclic amine compound based on the total weight of said lubricant composition.10. A crankcase lubricant composition according to wherein said base oil is selected from an API Group I Oil claim 1 , an API Group II Oil claim 1 , an API Group III Oil claim 1 , an API Group IV Oil claim 1 , and combinations thereof claim 1 , and wherein said base oil has a viscosity ranging from 1 to 20 cSt when tested at 100° C. according to ASTM D445.11. A crankcase lubricant composition according to wherein at least 90 wt. % of said acyclic amine compound remains ...

Alkoxylated Amides, Esters, And Anti-Wear Agents In Lubricant Compositions

The present disclosure provides an additive package for a lubricant composition that includes an alkoxylated amide, an ester, and an anti-wear agent including phosphorus, molybdenum, or a combination thereof. The present disclosure also provides a lubricant composition that includes a base oil, the alkoxylated amide, the ester, and the anti-wear agent including phosphorus, molybdenum, or a combination thereof. The present disclosure further provides a method of lubricating an internal combustion engine for improving fuel economy. 2. The lubricant composition of wherein said anti-wear agent comprises phosphorus.3. The lubricant composition of wherein said anti-wear agent is a zinc dialkyl dithiophosphate.4. The lubricant composition of wherein at least one of Rand Rof said alkoxylated amide comprises a propoxy group.8. The lubricant composition of wherein Rof said alkoxylated amide and said ester are each claim 1 , independently claim 1 , a linear or branched claim 1 , saturated or unsaturated claim 1 , C-Caliphatic hydrocarbyl group.9. The lubricant composition of wherein Rof said alkoxylated amide or said ester comprises a hydroxyl group.11. The lubricant composition of wherein:{'sup': '1', 'sub': 7', '23, 'each Ris, independently, a linear or branched, saturated or unsaturated, C-Caliphatic hydrocarbyl group;'}{'sup': '5', 'each Ris, independently, an ethyl group or a propyl group;'}{'sup': '6', 'each Ris, independently, a propoxy group;'}n is an integer from 0 to 5;m is an integer from 0 to 5;1≦(n+m)≦5;q is an integer from 0 to 5;if q is 0, p is an integer from 1 to 5;if q is >0, p is an integer from 1 to 5;1≦(p+q)≦5; andsaid lubricant composition comprises said alkoxylated amide and said ester in a weight ratio of less than 70:30 of said ester to said alkoxylated amide12. The lubricant composition of wherein said base oil is further defined as a crankcase lubricant composition.13. The lubricant composition of wherein said base oil comprises an API Group I Oil ...

MEDICAL SYSTEM AND METHOD OF USE

An instrument and method for applying thermal energy to targeted tissue. An instrument and method for tissue thermotherapy. In one embodiment, a method includes providing a vapor source comprising a pump configured for providing a flow of liquid media from a liquid media source into a vaporization chamber having a heating mechanism, actuating the pump to provide the liquid into the vaporization chamber, applying energy from the heating mechanism to convert a substantially water liquid media into a minimum water vapor level for causing an intended effect in tissue. For examples such levels can comprise at least 60% water vapor, at least 70% water vapor, at least 80% water vapor or at least 90% water vapor for causing an intended effect in tissue. 1. A method of ablating an endometrium of a uterus , the method comprising:inserting a probe working end through a cervix into the uterus, the probe comprising a vapor delivery lumen, a vapor exit port and a balloon disposed proximal to the vapor exit port;expanding the balloon such that the balloon prevents retrograde flow from the uterus;after the expanding step, delivering vapor from a vapor source to the uterus; andcondensing the vapor to thereby release heat of vaporization to ablate at least portions of the endometrium.2. The method of further comprising maintaining a pressure in the uterus between 0.1 psi and 50 psi.3. The method of further comprising maintaining a pressure in the uterus between 0.2 psi and 10 psi.4. The method of further comprising maintaining a pressure in the uterus between 0.5 psi and 5 psi.5. The method of wherein the vapor comprises water vapor.6. The method of wherein the delivering step comprises delivering the vapor at a flow rate in a range of 0.001 ml/min to 20 ml/min.7. The method of wherein the delivering step comprises delivering the vapor at an inflow pressure in a range of 0.5 psi to 1000 psi.8. The method of wherein the delivering step comprises delivering the vapor for an interval in ...

COMPOSITION AND METHOD OF FORMING THE SAME

A composition comprises the reaction product of a dithiophosphate derivative and an amine. The reaction product is present in the composition in an amount of at least about 25 wt. %. The composition may include additional components. A method of forming the composition comprises the step of combining the dithiophosphate derivative and the amine to form the composition. A method of increasing thermal stability of a dithiophosphate derivative comprises the step of combining the dithiophosphate derivative and an amine. The dithiophosphate derivative can decompose to form hydrogen sulfide (H2S). However, the amine substantially prevents thermal decomposition of the dithiophosphate derivative. An example of the dithiophosphate derivative is 3-(di-isobutoxy-thiophosphorylsulfanyl)-2-methyl-propanoic acid. An example of the amine is ditridecyl amine. The composition can be used for a variety of applications. For example, the composition can be used as an antiwear compound/additive in lubricants, metalworking fluids, hydraulic fluids, etc. 120.. (canceled)22. The composition as set forth in claim 21 , wherein the reaction product is present in an amount of at least about 50 wt. % based on total weight of the composition.23. The composition as set forth in claim 21 , wherein the reaction product is present in an amount of at least about 75 wt. % based on total weight of the composition.24. The composition as set forth in claim 22 , wherein the amine is selected from the group consisting of secondary aliphatic amine claim 22 , ethylene diamine claim 22 , toluene diamine claim 22 , 1 claim 22 ,3-diaminpropane claim 22 , putrescine claim 22 , cadaverine claim 22 , hexamethylenediamine claim 22 , 1 claim 22 ,2-diaminopropane claim 22 , diphenylethylenediamine claim 22 , diaminocyclohexane claim 22 , xylylenediamine claim 22 , phenylenediamine claim 22 , benzidine claim 22 , spermidine claim 22 , spermine claim 22 , toluene diamine claim 22 , aminobenzylamine claim 22 , polyether ...

VAPOR ABLATION SYSTEMS AND METHODS

A vapor delivery system and method is provided that is adapted for treating prostate tissue. The vapor delivery system includes a vapor delivery needle configured to deliver condensable vapor energy to tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the prostate tissue. The vapor delivery system includes a generator unit and an inductive heating system to produce a high quality vapor for delivery to tissue. Methods of use are also provided. 1. A vapor delivery system , comprising:a generator unit including a cradle;a syringe assembly disposed in the cradle and configured to interact with the cradle to deliver a fluid at a controlled rate;an inductive heating system fluidly coupled to the syringe assembly and configured to receive fluid from the syringe assembly;a force sensor disposed in the cradle and configured contact the cradle and/or syringe assembly to generate an electrical signal proportional to a force exerted on the force sensor by the cradle and/or syringe assembly; andan electronic controller configured control delivery of fluid and RF power to the inductive heating system for the production of vapor, the electronic controller being further configured to calibrate the electrical signal as representing a fluid pressure within the syringe assembly, the electronic controller being further configured to stop delivery of fluid and/or RF power to the inductive heating system when the fluid pressure falls outside of a desired range of fluid pressures.2. The system of claim 1 , wherein the cradle is arranged such that a distal end of the syringe assembly is held at a higher elevation than a proximal end of the syringe assembly when the syringe assembly is inserted into the cradle.3. The system of claim 2 , wherein the cradle is configured to purge any air from the syringe assembly during a priming procedure in which fluid is force from the syringe assembly through the vapor delivery system.4. The system of ...

SYSTEMS AND METHODS FOR TREATMENT OF PROSTATIC TISSUE

A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Methods associated with use of the prostate therapy system are also covered. 115.-. (canceled)16. A method of treating a disorder of a prostate , the method comprising:advancing a vapor ablation probe transurethrally into the prostate so that, within the prostate, the vapor ablation probe extends further in a longitudinal direction along a length of a urethra than in a transverse direction perpendicular to the longitudinal direction;delivering energy to the prostate via condensable vapor; andablating a tissue of the prostate.17. The method of claim 16 , wherein the advancing the vapor ablation probe includes orienting a plurality of vapor ports of the vapor ablation probe toward the urethra.18. The method of claim 17 , wherein the delivering the energy includes delivering the condensable vapor toward the urethra.19. The method of claim 16 , wherein the advancing the vapor ablation probe includes advancing an introducer into the urethra and advancing the ablation probe through the introducer claim 16 , and wherein at least part of the introducer and at least part of the ablation probe have complementary shapes preventing rotation of the ablation probe within the introducer.20. The method of claim 16 , wherein the vapor ablation probe has a curved shape.21. The method of claim 16 , wherein the advancing the vapor ablation probe includes advancing the vapor ablation probe from an apex of a lobe of the prostate toward a base of the lobe of the prostate.22. The method of claim 16 , wherein the delivering the energy includes delivering the condensable vapor in the transverse direction.23. The method of claim 16 , wherein the vapor ablation probe has a first ...

Seal Compatibility Additive To Improve Fluoropolymer Seal Compatibility of Lubricant Compositions

This disclosure is directed to an additive package for a lubricant composition that provides improved compatibility with fluoropolymer seals. The additive package comprises a seal compatibility additive. The disclosure is also directed to a lubricant composition comprising a base oil and a seal compatibility additive. The seal compatibility additive improves the compatibility with fluoropolymer seals of the resultant lubricant composition. 1. An additive package for a lubricant composition that provides improved compatibility with fluoropolymer seals , said additive package comprising:a seal compatibility additive comprising at least one iodine atom and having a boiling point of from 150 to 450° C. at 1 atmosphere.2. The additive package of wherein said seal compatibility additive comprises an acyclic hydrocarbon backbone comprising at least one carbon atom claim 1 , andwherein said at least one iodine atom is bonded to said at least one carbon atom in said acyclic hydrocarbon backbone.4. The additive package of wherein said alkyl iodide compound comprises iodododecane.5. The additive package of further comprising an amine compound.6. The additive package of wherein said amine compound comprises a sterically hindered amine compound.8. The additive package of wherein said amine compound comprises an amine dispersant.9. The additive package of further comprising anti-wear agent comprising phosphorous.10. A lubricant composition that provides improved compatibility with fluoropolymer seals claim 1 , said lubricant composition comprising:a base oil; anda seal compatibility additive comprising at least one iodine atom and having a boiling point of from 150 to 450° C. at 1 atmosphere.11. The lubricant composition of wherein said seal compatibility additive comprises:an acyclic hydrocarbon backbone comprising at least one carbon atom,wherein said at least one iodine atom is bonded to said at least one carbon atom in said acyclic hydrocarbon backbone.13. The lubricant ...

Lubricant Composition

A lubricant composition is substantially free of water and includes a base oil present in an amount of greater than 85 parts by weight per 100 parts by weight of the lubricant composition, includes an antioxidant, and includes one or more alkylethercarboxylic acid corrosion inhibitor(s) present in an amount of from 0.01 to 1 weight percent based on a total weight of said lubricant composition. The one or more alkylethercarboxylic acid corrosion inhibitor(s) have the formula; wherein R is a straight or branched chain C 6 -C 18 alkyl group and n is a number of from 0 to 5.

METHODS FOR DELIVERING ENERGY INTO A TARGET TISSUE OF A BODY

An instrument and method for tissue thermotherapy including an inductive heating means to generate a vapor phase media that is used for interstitial, intraluminal, intracavity or topical tissue treatment. In one method, the vapor phase media is propagated from a probe outlet to provide a controlled vapor-to-liquid phase change in an interface with tissue to thereby apply ablative thermal energy delivery. 1. A method of delivering energy into a target tissue of a body region , the method comprising:advancing a working end of a device into the body region;expanding a structure from within a working end of the device into the body region, where at least a portion of the thin wall structure is permeable to allow transfer of a medium through the structure to the tissue; anddelivering an amount of energy from the structure to treat the target tissue of the body region wherein delivering the amount of energy comprises delivering energy using a vapor media by passing the vapor media through the structure.2. The method of claim 1 , where expanding the structure comprises everting the structure.3. The method of claim 1 , where expanding the structure comprises inflating claim 1 , unfolding claim 1 , unfurling or unrolling the structure.4. The method of claim 1 , where the structure comprises a thin wall structure.5. (canceled)6. The method of claim 1 , where delivering the amount of energy to treat the target tissue comprises ablating the target tissue.711.-. (canceled)12. The method of wherein the structure comprises at least one vapor outlet.13. The method of claim 1 , where the permeable portion of the structure comprises a plurality of permeable portions claim 1 , where at least a porosity of one of the permeable portion varies such that delivery of the amount of energy is non-uniform about the structure when expanded.14. The method of claim 13 , where delivering the amount of energy comprises delivering a first amount of energy at a central portion of the structure when ...

APPARATUS AND METHOD FOR CREATING, MAINTAINING, AND CONTROLLING A VIRTUAL ELECTRODE USED FOR THE ABLATION OF TISSUE

An apparatus and a method for producing a virtual electrode within or upon a tissue to be treated with radio frequency alternating electric current. An apparatus in accord with the present disclosure includes a supply of a conductive or electrolytic fluid to be provided to the patient, an alternating current generator, and a processor for creating, maintaining, and controlling the ablation process by the interstitial or surficial delivery of the fluid to a tissue and the delivery of electric power to the tissue via the virtual electrode. A method in accord with the present disclosure includes delivering a conductive fluid to a predetermined tissue ablation site for a predetermined time period, applying a predetermined power level of radio frequency current to the tissue, monitoring at least one of several parameters, and adjusting either the applied power and/or the fluid flow in response to the measured parameters. 1. A system for producing , maintaining , and controlling a virtual electrode for provision of an ablative therapy through the virtual electrode to a target tissue of a body of a patient , the system providing a conductive fluid and an RF power to the target tissue to create the virtual electrode , the system comprising:a source of conductive fluid selectively providing conductive fluid to the target tissue;a surgical instrument including an electrode for delivering RF power to distributed conductive fluid to create a virtual electrode;a primary temperature sensor for sensing a temperature of the body of the patient in an area of the target tissue;an impedance detector for measuring information indicative of an impedance of the body of the patient in the area of the target tissue to passage of RF current; anda processor for determining a desired RF power applied by the electrode as Ablation_RF_Power=(max_RF_Power)*(proportional feedback+integral feedback+derivative feedback);wherein max_RF_Power is a maximum power level determined as a function of the ...

VAPOR ABLATION SYSTEMS AND METHODS

A vapor delivery system and method is provided that includes a number of features. In one embodiment, a method comprises inserting a vapor delivery needle into tissue of a patient, activating a flow of vapor from a vapor generator through vapor delivery ports of the vapor delivery needle to cause condensed liquid to exit vapor delivery ports of the vapor delivery needle, generating vapor in the vapor generator, delivering a dose of vapor through the vapor delivery ports of the vapor delivery needle into the tissue, and after the dose of vapor is delivered, re-activating the flow of vapor from the vapor generator through the vapor delivery ports of the vapor delivery needle to prevent a vacuum from forming in the vapor delivery needle. Vapor therapy systems are also provided. 1. A method for providing vapor therapy , comprising:inserting a vapor delivery needle into tissue of a patient;activating a flow of vapor from a vapor generator through vapor delivery ports of the vapor delivery needle to cause condensed liquid to exit vapor delivery ports of the vapor delivery needle;generating vapor in the vapor generator;delivering a dose of vapor through the vapor delivery ports of the vapor delivery needle into the tissue; andafter the dose of vapor is delivered, re-activating the flow of vapor from the vapor generator through the vapor delivery ports of the vapor delivery needle to prevent a vacuum from forming in the vapor delivery needle.2. The method of claim 1 , wherein the generating step further comprises heating a heating element that surrounds a flow of fluid to inductively generate the vapor.3. The method of claim 2 , further comprising monitoring a parameter of the heating element with an electronic controller claim 2 , and controlling the parameter at a set value with the electronic controller to insure consistent caloric content of the delivered vapor.4. The method of claim 3 , wherein the parameter is a temperature of the heating element.5. The method of ...

Vapor ablation systems and methods

A vapor delivery system and method is provided that is adapted for treating prostate tissue. The vapor delivery system includes a vapor delivery needle configured to deliver condensable vapor energy to tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the prostate tissue. The vapor delivery system includes a generator unit and an inductive heating system to produce a high quality vapor for delivery to tissue. Methods of use are also provided.

Lubricant Composition

A lubricant composition for a compression-ignition internal combustion engine comprises: (i) an amine as an ashless fuel additive having a total base number (“TBN”) of from about 275 to about 600 mg KOH/g when tested according to ASTM D2896; and (ii) a detergent selected from metal sulfonates, phenates, salicylates, carboxylates, thiophosphonates, and combinations thereof. The lubricant composition has a TBN of from about 20 to about 130 mg KOH/g when tested according to ASTM D2896. The amine contributes greater than about 30% of the TBN of the lubricant composition. Further, a method of lubricating an internal combustion engine with the lubricant composition comprises the steps of injecting a fuel and the lubricant composition into a cylinder to form a mixture, and combusting the mixture via compression-ignition. 1. A lubricant composition for a compression-ignition internal combustion engine , said lubricant composition comprising:(i) an amine as an ashless fuel additive having a TBN of from about 275 to about 600 mg KOH/g when tested according to ASTM D2896, and(ii) a detergent selected from metal sulfonates, phenates, salicylates, carboxylates, thiophosphonates, and combinations thereof,wherein a TBN of said lubricant composition is from about 20 to about 130 mg KOH/g when tested according to ASTM D2896; andwherein a TBN contribution of said amine to said TBN of said lubricant composition is greater than about 30%.2. A lubricant composition as claimed in claim 1 , wherein a TBN contribution of said amine to said TBN of said lubricant composition is greater than a TBN contribution of said detergent to said TBN of said lubricant composition.8. A lubricant composition as claimed in claim 1 , wherein said amine is present in an amount of from about 1 to about 45 wt. % based on the total weight of said lubricant composition.9. A lubricant composition as claimed in claim 1 , wherein said detergent comprises an overbased metal and/or said detergent is present in an ...

Lubricant Composition

A lubricant composition for a compression-ignition internal combustion engine comprises: (i) an amine as an ashless fuel additive having a total base number (“TBN”) of from about 200 to about 600 mg KOH/g when tested according to ASTM D2896; and (ii) a detergent selected from metal sulfonates, phenates, salicylates, carboxylates, thiophosphonates, and combinations thereof. The lubricant composition has a TBN of from about 20 to about 130 mg KOH/g when tested according to ASTM D2896, The amine contributes greater than about 30% of the TBN of the lubricant composition. Further, a method of lubricating an internal combustion engine with the lubricant composition comprises the steps of injecting a fuel and the lubricant composition into a cylinder to form a mixture, and combusting the mixture via compression-ignition. 1. A lubricant composition for a compression-ignition internal combustion engine , said lubricant composition comprising:(i) an amine as an ashless fuel additive having a total base number (“TBN”) of from about 200 to about 600 mg KOH/g when tested according to ASTM D2896, and(ii) a detergent selected from metal sulfonates, phenates, salicylates, carboxylates, thiophosphonates, and combinations thereof,wherein a TBN of said lubricant composition is from about 20 to about 130 mg KOH/g when tested according to ASTM D2896; andwherein a TBN contribution of said amine to said TBN of said lubricant composition is greater than about 30%.2. A lubricant composition as claimed in claim 1 , wherein a TBN contribution of said amine to said TBN of said lubricant composition is greater than a TBN contribution of said detergent to said TBN of said lubricant composition.3. A lubricant composition as claimed in claim 1 , wherein said amine has a TBN of from about 250 to about 550 mg KOH/g when tested according to ASTM D2896.5. A lubricant composition as claimed in claim 4 , wherein at least one of R claim 4 , R claim 4 , and Ris a branched or a cyclic hydrocarbon group.7. ...

COMPOSITION AND METHOD OF FORMING THE SAME

A composition comprises the reaction product of a dithiophosphate derivative and an amine. The reaction product is present in the composition in an amount of at least about 25 wt. %. The composition may include additional components. A method of forming the composition comprises the step of combining the dithiophosphate derivative and the amine to form the composition. A method of increasing thermal stability of a dithiophosphate derivative comprises the step of combining the dithiophosphate derivative and an amine. The dithiophosphate derivative can decompose to form hydrogen sulfide (H2S). However, the amine substantially prevents thermal decomposition of the dithiophosphate derivative. An example of the dithiophosphate derivative is 3-(di-isobutoxy-thiophosphorylsulfanyl)-2-methyl-propanoic acid. An example of the amine is ditridecyl amine. The composition can be used for a variety of applications. For example, the composition can be used as an antiwear compound/additive in lubricants, metalworking fluids, hydraulic fluids, etc. 1. A composition comprising: a dithiophosphate derivative, and', 'an amine;, 'the reaction product of;'}wherein the reaction product is present in an amount of at least about 25 wt. %.2. The composition as set forth in claim 1 , wherein the reaction product is present in an amount of at least about 50 wt. %.3. The composition as set forth in claim 1 , wherein the reaction product is present in an amount of at least about 75 wt. %.5. The composition as set forth in claim 4 , wherein Rand Rindependently of one another are C-Calkyl claim 4 , C-Ccycloalkyl claim 4 , or C-Calkylphenyl.6. The composition as set forth in claim 4 , wherein Ris hydrogen and the sum of n+m is from 1 to 25.7. The composition as set forth in claim 1 , wherein said dithiophosphate derivative is β-dithiophosphorylated propionic acid.8. The composition as set forth in claim 1 , wherein said amine has a number average molecular weight (M) less than about 3 claim 1 ,000.9 ...

SYSTEMS AND METHODS FOR TREATING THE BLADDER WITH CONDENSABLE VAPOR

A vapor delivery system and method is provided that is adapted for ablating bladder tissue to treat overactive bladder (OAB). The vapor delivery system includes an anchor tip configured anchor the system in the bladder while condensable vapor is delivered to target tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the target tissue of the bladder, which can include a surface sensor of the bladder responsible for creating an urge incontinence sensation. The vapor delivery system includes a vapor source that provides a high quality vapor for delivery to tissue.

Lubricant Composition

Lubricant compositions comprising a base oil, one or more antioxidants selected from a group consisting of N-α-naphthyl-N-phenylamine antioxidants and diphenylamine antioxidants; and one or more sulfur-containing additives exhibit outstanding oxidative stability and non-corrosion properties. The N-α-naphthyl-N-phenylamine antioxidants plus diphenylamine antioxidants in total may be present from about 0.2 wt % to about 0.8 wt %, based on the total weight of the lubricant composition. The sulfur provided by the sulfur-containing additives, in total, may be present from about 50 ppm to about 1000 ppm by weight, based on the total weight of the lubricant composition. 1. A lubricant composition comprisinga base oil,one or more antioxidants selected from a group consisting of N-a-naphthyl-N-phenylamine antioxidants and diphenylamine antioxidants; andone or more sulfur-containing additives.2. The lubricant composition according to claim 1 , wherein the N-α-naphthyl-N-phenylamine antioxidants plus diphenylamine antioxidants in total are present from about 0.2 wt % to about 0.8 wt % claim 1 , based on the total weight of the lubricant composition.3. The lubricant composition according to claim 1 , wherein a sulfur concentration provided by the sulfur-containing additives claim 1 , in total claim 1 , range from about 50 ppm to about 1000 ppm by weight claim 1 , based on the total weight of the lubricant composition.7. The lubricant composition according to claim 1 , wherein the sulfur-containing additives are selected from a group consisting of sulfur-containing hindered phenolic compounds claim 1 , sulfur-containing rust inhibitors claim 1 , sulfur-containing friction modifiers and sulfur-containing antiwear additives.8. The lubricant composition according to claim 1 , comprising one or more sulfur-containing additives selected from a group consisting of 2 claim 1 ,4-di-octylthiomethyl-6-tert-butylphenol claim 1 , 2 claim 1 ,4-di-octylthiomethyl-6-methylphenol claim 1 , 2 ...

SYSTEMS AND METHODS FOR TREATING THE BLADDER WITH CONDENSABLE VAPOR

A vapor delivery system and method is provided that is adapted for ablating bladder tissue to treat overactive bladder (OAB). The vapor delivery system includes an anchor tip configured anchor the system in the bladder while condensable vapor is delivered to target tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the target tissue of the bladder, which can include a surface sensor of the bladder responsible for creating an urge incontinence sensation. The vapor delivery system includes a vapor source that provides a high quality vapor for delivery to tissue. 1. A method for treating overactive bladder in a patient , comprising the steps of:inserting a vapor delivery catheter into a urethra of the patient;advancing a distal anchor tip of the vapor delivery catheter transurethrally into a bladder of the patient;positioning the distal anchor tip on or adjacent to a target tissue including a surface sensor of the bladder responsible for creating an urge incontinence sensation;advancing the distal anchor tip into the target tissue to deform the bladder without puncturing the bladder; anddelivering vapor through the vapor delivery system to the target tissue to ablate the target tissue including the surface sensor.2. The method of claim 1 , further comprising delivering between 1 and 500 calories of energy to the target tissue.3. The method of claim 1 , further comprising advancing the distal anchor tip less than 10 mm into the target tissue.4. The method of claim 1 , further comprising advancing the distal anchor tip less than 5 mm into the target tissue.5. The method of claim 1 , wherein the distal anchor tip cannot extend more than 5 mm into the target tissue.6. The method of claim 1 , wherein the distal anchor tip cannot extend more than 1-2 mm into the target tissue.7. The method of claim 1 , wherein the advancing step further comprises advancing a needle of the distal anchor tip into the target tissue.8. The ...

Lubricant Compositions Comprising Trimethoxyboroxines and Sterically Hindered Amines To Improve Fluoropolymer Seal Compatibilty

A lubricant composition including a boroxine compound is disclosed. A lubricant composition and additive package including a boroxine compound and a sterically hindered amine compound are also disclosed. The boroxine compound of the lubricant composition acts to improve compatibility of the lubricant composition with a fluoropolymer seal. 2. The lubricant composition of wherein said boroxine compound is included in an amount ranging from 0.1 to 5 wt. % based on said total weight of said lubricant composition.3. The lubricant composition of wherein at least 50 wt. % of said boroxine compound remains unreacted in said lubricant composition based on said total weight of said boroxine compound utilized to form said lubricant composition prior to any reaction in said lubricant composition.4. The lubricant composition of wherein said sterically hindered amine compound comprises at least one piperidine ring and at least one ester group.5. The lubricant composition of wherein said sterically hindered amine compound is (2 claim 1 ,2 claim 1 ,6 claim 1 ,6-tetramethyl-4-piperidyl) dodecanoate.6. The lubricant composition of wherein said sterically hindered amine compound has a total base number of at least 70 mg KOH/g when tested according to ASTM D4739.7. The lubricant composition of wherein said base oil has a viscosity ranging from 1 to 20 cSt when tested at 100° C. according to ASTM D445 and is selected from the group of API group I oils claim 1 , API group II oils claim 1 , API group III oils claim 1 , API group IV oils claim 1 , API group V oils claim 1 , and combinations thereof.8. The lubricant composition of further comprising a dispersant.9. The lubricant composition of wherein said dispersant is a polyalkene amine derived from a polyisobutene.10. The lubricant composition of wherein said dispersant is included in said lubricant composition in an amount ranging from 0.01 to 15 wt. % based on said total weight of said lubricant composition.11. The lubricant ...

SYSTEMS AND METHODS FOR TREATING PROSTATE CANCER

A vapor delivery needle and method is provided that is adapted for treating prostate cancer. The energy delivery probe can apply condensable vapor energy to tissue, such as a peripheral zone tissue in a human prostate. In one method, a needle is introduced into peripheral zone tissue of a human prostate, and vapor media is delivered through the needle to ablate peripheral zone tissue without ablating non-peripheral zone tissue. Systems for treating prostate cancer with vapor therapy are also provided. 139.-. (canceled)40. A method of treatment , the method comprising:inserting a vapor delivery needle into a peripheral zone lobe of a prostate;using the vapor delivery needle, delivering a vapor into the peripheral zone lobe;using the delivered vapor, ablating an entirety of the peripheral zone lobe.41. The method of claim 40 , wherein the delivered vapor is retained within a prostate capsule such that tissue outside of the prostate is not ablated.42. The method of claim 40 , wherein the delivering the vapor step ablates only the peripheral zone lobe of the prostate.43. The method of claim 40 , wherein the ablating step destroys cancerous claim 40 , tissue in the peripheral zone lobe.44. The method of claim 40 , wherein the vapor delivery needle includes a removable sheath having a pair of concentric tubes forming an insulating layer between the pair of concentric tubes claim 40 , and wherein the sheath is tapered.45. The method of claim 40 , wherein the vapor is delivered while the needle is moving.46. The method of claim 40 , further comprising measuring a temperature of the prostate.47. The method of claim 46 , further comprising positioning a temperature probe exterior of the prostate.48. The method of claim 46 , further comprising ceasing to deliver vapor when an exterior portion of the prostate reaches a temperature between 47 degrees C. and 52 degrees C.49. The method of claim 40 , wherein the delivering the vapor step provides vapor for 20 seconds to 60 seconds ...

TUNED RF ENERGY AND ELECTRICAL TISSUE CHARACTERIZATION FOR SELECTIVE TREATMENT OF TARGET TISSUES

A catheter and catheter system can use energy tailored for remodeling and/or removal of target material along a body lumen, often of atherosclerotic material of a blood vessel of a patient. An elongate flexible catheter body with a radially expandable structure may have a plurality of electrodes or other electrosurgical energy delivery surfaces to radially engage atherosclerotic material when the structure expands. An atherosclerotic material detector system may measure and/or characterize the atherosclerotic material and its location, optionally using impedance monitoring. 1. A system for characterizing and treating a target tissue in a patient body , the system comprising:a probe having an electrode for aligning with the target tissue of the patient body,an RF energy source couplable to the probe, the RF source having a first mode and a second mode, the RF source in the first mode configured to apply a tissue characterizing energy, the probe, the RF source, the target tissue, and a collateral tissue included in a circuit when the probe is coupled to the RF source and the electrode is aligned with the target tissue;a processor coupled to the RF source, the processor configured to:characterize the target tissue by measuring a phase angle of the circuit while the circuit is energized with, the characterization energy; anddetermine an appropriate treatment energy from the measured phase angle of the circuit for use in the second mode of the RF source so as to heat the target tissue.2. The system of claim 1 , wherein the RF energy source in the second mode applies the treatment energy with a treatment phase angle in response to a treatment phase angle input claim 1 , the processor configured to determine the treatment phase angle input so as to compensate for the measured phase angle.3. The system of claim 1 , the collateral tissue of the circuit having an associated impedance magnitude and an associated phase angle for each of a plurality of RF frequencies of the ...

VAPOR ABLATION SYSTEMS AND METHODS

A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the vapor delivery needle can be advanced a predetermined distance into the prostate with a solenoid actuation mechanism. Methods associated with use of the energy delivery probe are also covered. 1. A prostate treatment device , comprising:an introducer shaft sized and configured for transurethral access into a patient;a handle coupled to the introducer shaft;a vapor generator disposed in the handle and configured to generate a condensable vapor;a vapor delivery needle in communication with the vapor generator and slidably disposed within the introducer shaft;a magnet attached to the needle; anda solenoid actuator disposed around the magnet, the solenoid actuator comprising a push winding coupled to a source of RF current and a pull winding coupled to the source of RF current, the push winding being configured to apply a first magnetic field to the magnet, the pull winding being configured to apply a second magnetic field to the magnet, wherein the first and second magnetic fields move a distal tip of the vapor delivery needle between a retracted position inside the introducer shaft and an extended position at least partially outside of the introducer shaft.2. The device of claim 1 , wherein the first magnetic field shares a polarity with the magnet.3. The device of claim 1 , wherein the second magnetic field has a polarity opposite to a polarity of the magnet.4. The device of claim 1 , wherein the combination of the first and second magnetic fields removes lateral movements of the magnet as the vapor delivery needle moves between the retracted position and the extended position.5. The device of claim 1 , wherein the combination of the first and second magnetic fields approximately doubles a force ...

SYSTEMS AND METHODS FOR TREATING THE PROSTATE

A vapor delivery system and method is provided that is adapted for treating prostate tissue. The vapor delivery system includes a vapor delivery needle configured to deliver condensable vapor energy to tissue. In one method, the vapor delivery system is advanced transurethrally into the patient to access the prostate tissue. The vapor delivery system is properly positioned by measuring and advancing the system based on a field-of-view of an endoscope or camera disposed within the system. 1. A method for treating a prostate , comprising the steps of:inserting a vapor delivery system into a urethra of a patient;advancing a distal portion of the vapor delivery system to a bladder neck of the patient;viewing the distal portion of the vapor delivery system with a camera disposed on or within the vapor delivery system;measuring a distance from the bladder neck to a first treatment region in a first lobe of the prostate with a field of view of the camera;pulling the distal portion of the vapor delivery system proximally across the field of view of the camera to the first treatment region;deploying a vapor delivery needle from the vapor delivery system into the first treatment region of the first lobe; anddelivering vapor into the first treatment region of the first lobe of the prostate to ablate tissue in the prostate.2. The method of claim 1 , further comprising claim 1 , prior to the measuring step claim 1 , measuring a distance from the bladder neck to a veru of the patient.3. The method of claim 2 , further comprising determining a number of treatments to perform based on the distance from the bladder neck to the veru.4. The method of claim 1 , wherein the delivering step comprises delivering between 160-300 calories of energy into the prostate.5. The method of claim 1 , wherein the measuring step further comprises determining a distance traveled by the vapor delivery system when it is moved across the field of view of the camera.6. The method of claim 1 , further ...

LUBRICANT COMPOSITION

Lubricant compositions comprising a base oil, one or more antioxidants selected from a group consisting of N-α-naphthyl-N-phenylamine antioxidants and diphenylamine antioxidants; and a sulfur-containing additive comprising up to seven carbon atoms exhibit outstanding oxidative stability and non-corrosion properties. The N-α-naphthyl-N-phenylamine antioxidants plus diphenylamine antioxidants in total may be present from about 0.2 wt % to about 0.8 wt %, based on the total weight of the lubricant composition. The sulfur provided by the sulfur-containing additive may be present from about 50 ppm to about 1000 ppm by weight, based on the total weight of the lubricant composition. 120.-. (canceled)21. A lubricant composition comprisinga base oil,one or more antioxidants selected from a group consisting of N-α-naphthyl-N-phenylamine antioxidants and diphenylamine antioxidants; anda sulfur-containing additive comprising up to 7 carbon atoms.22. The lubricant composition according to claim 21 , wherein the N-α-naphthyl-N-phenylamine antioxidants plus diphenylamine antioxidants in total are present from about 0.2 wt % to about 0.8 wt % claim 21 , based on the total weight of the lubricant composition.23. The lubricant composition according to claim 21 , wherein a total sulfur concentration provided by the sulfur-containing additive ranges from about 50 ppm to about 1000 ppm by weight claim 21 , based on the total weight of the lubricant composition.25. The lubricant composition according to claim 21 , further comprising at least one additional sulfur-containing additive selected from a group consisting of sulfur-containing hindered phenolic compounds claim 21 , sulfur-containing rust inhibitors claim 21 , sulfur-containing friction modifiers and sulfur-containing antiwear additives.26. The lubricant composition according to claim 21 , wherein the sulfur-containing additive is a sulfurized isobutylene.27. The lubricant composition according to claim 26 , wherein the ...

Intraluminal electrical tissue characterization and tuned rf energy for selective treatment of atheroma and other target tissues

A catheter and catheter system can use energy tailored for remodeling and/or removal of target material along a body lumen, often of atherosclerotic material of a blood vessel of a patient. An elongate flexible catheter body with a radially expandable structure may have a plurality of electrodes or other electrosurgical energy delivery surfaces to radially engage atherosclerotic material when the structure expands. An atherosclerotic material detector system may measure and/or characterize the atherosclerotic material and its location, optionally using impedance monitoring.

Tuned rf energy and electrical tissue characterization for selective treatment of target tissues

A catheter and catheter system can use energy tailored for remodeling and/or removal of target material along a body lumen, often of atherosclerotic material of a blood vessel of a patient. An elongate flexible catheter body with a radially expandable structure may have a plurality of electrodes or other electrosurgical energy delivery surfaces to radially engage atherosclerotic material when the structure expands. An atherosclerotic material detector system may measure and/or characterize the atherosclerotic material and its location, optionally using impedance monitoring.

System for inducing desirable temperature effects on body tissue

A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engages tissue including diseased tissue when the structure expands.

Inducing desirable temperature effects on body tissue

Methods and systems are disclosed for treating diseased tissue by gentle heating. The method induces vasodilation on tissue disposed about an lumen having both healthy tissue and diseased tissue. The method includes coupling a probe surface to the luminal tissue at a target location and transmitting desired quantities of tissue remodeling energy from the coupled probe into each of a plurality of discrete remodeling zones in the luminal tissue so that the tissue remodeling energy heats the plurality of remodeling zones, the remodeling energy being configured to avoid muscular contraction and inhibit both acute and long-term occlusion of the lumen.

Directional delivery of energy and bioactives

Systems and methods are disclosed for the treatment of a target tissue by directionally delivering energy and/or bioactive materials to achieve a therapeutic effect. A balloon catheter system having a balloon portion and a plurality of electrodes may be energized to selectively deliver energy, bioactive materials, or a combination thereof to target tissue including tissues disposed about a lumen. The tissue may be targeted by applying energy, making tissue impedance analysis, and further selectively energizing electrodes through the use of an energy source with a controller.

Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue

The present invention provides an apparatus and a method for producing a virtual electrode within or upon a tissue to be treated with radio frequency alternating electric current, such tissues including but not limited to liver, lung, cardiac, prostate, breast, and vascular tissues and neoplasms. An apparatus in accord with the present invention includes a supply of a conductive or electrolytic fluid to be provided to the patient, an alternating current generator, and a processor for creating, maintaining, and controlling the ablation process by the interstitial or surficial delivery of the fluid to a tissue and the delivery of electric power to the tissue via the virtual electrode. A method in accord with the present invention includes delivering a conductive fluid to a predetermined tissue ablation site for a predetermined time period, applying a predetermined power level of radio frequency current to the tissue, monitoring at least one of several parameters, and adjusting either the applied power and/or the fluid flow in response to the measured parameters.

Tissue sealing electrosurgery device and methods of sealing tissue

An electrosurgery medical device is enhanced with unique solution-assistance, and includes, in combination, co-operating device jaws including jaw portions for manipulating tissue, and a plurality of solution infusion openings defined and spaced along each of the jaw portions, for receiving electrolytic solution and infising the solution onto and into tissue to be manipulated, along said jaw portions. As preferred, the device further comprises at least one, and most preferably, many, longitudinal groove(s) along at least one and most preferably, both, of the jaw portions, with the solution infusion openings located in the groove or grooves. The solution is energized with RF energy and contributes to the functions and beneficial effects of the instrument. The solution exits the openings in the grooves at sufficient flow rates to separate substantially all the operative surfaces of the device from tissue, thereby substantially completely preventing adherence between the operative surfaces and tissue. The solution is further energized to a range of energy densities such that tissues to be affected are sealed against flow of blood, lymphatic fluids, air, and other bodily fluids and gases.

Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue

An apparatus and a method for producing a virtual electrode within or upon a tissue to be treated with radio frequency alternating electric current. An apparatus in accord with the present disclosure includes a supply of a conductive or electrolytic fluid to be provided to the patient, an alternating current generator, and a processor for creating, maintaining, and controlling the ablation process by the interstitial or surficial delivery of the fluid to a tissue and the delivery of electric power to the tissue via the virtual electrode. A method in accord with the present disclosure includes delivering a conductive fluid to a predetermined tissue ablation site for a predetermined time period, applying a predetermined power level of radio frequency current to the tissue, monitoring at least one of several parameters, and adjusting either the applied power and/or the fluid flow in response to the measured parameters.

Devices and method for manipulation of organ tissue

Devices and methods of manipulating and stabilizing organ tissue, such as heart tissue. The devices, which are of varying sizes, shapes and conformations, generally include a seal member having a chamber with a wall and a skirt-like member that extends outward from the chamber wall for contact with a surface of an organ. The skirt-like member is substantially compliant and tacky, thereby promoting adhesion with the organ surface. Adherence of the device to the tissue may be enhance by the mechanical or hydraulic application of vacuum pressure. The methods describe steps for manipulating, including moving, lifting, immobilizing, turning and reorienting, organ tissues. Additional methods describe steps for manipulating the heart.

Surgical devices and methods for use in tissue ablation procedures

Devices and a method are provided to assist a surgeon in ablating conduction paths in tissue, such as a heart. A device can be configured to operate as a template that adheres to the tissue surface, and allows the surgeon to more easily sever the conduction path to form a lesion in a desired location. In particular, the template can be used to guide the surgeon's use of a surgical instrument along a desired ablation path. In some case, the template may incorporate hardware that structurally supports the instrument for travel along the ablation path. A surgical instrument such as an ablation probe, e.g., radio frequency, laser, ultrasonic, microwave, thermal, chemical, mechanical, or cryogenic ablation probe, may be used to sever the conduction paths. Measurements made substantially contemporaneously with the conduction path ablation operation may be used to evaluate whether the desired degree of ablation has been achieved. The device may also incorporate feedback to compare the desired degree of conduction path ablation with the measured degree, and may deactivate the surgical instrument when the desired degree has been achieved. In some cases, the template device can be configured to provide local stabilization of organ tissue, particularly for a moving organ such as a beating heart. In other cases, the template device may provide little or no stabilization, but provide a guide structure for placement of the ablation probe in the same frame of motion as the moving tissue. Also, for some applications, the template device may be arranged to facilitate application of other therapeutic devices, such as diagnostic probes, pacing leads, and drug delivery devices, to the surface of a moving organ.

Devices and method for manipulation of organ tissue

Devices and methods of manipulating and stabilizing organ tissue, such as heart tissue. The devices, which are of varying sizes, shapes and conformations, generally include a seal member having a chamber with a wall and a skirt-like member that extends outward from the chamber wall for contact with a surface of an organ. The skirt-like member is substantially compliant and tacky, thereby promoting adhesion with the organ surface. Adherence of the device to the tissue may be enhance by the mechanical or hydraulic application of vacuum pressure. The methods describe steps for manipulating, including moving, lifting, immobilizing, turning and reorienting, organ tissues. Additional methods describe steps for manipulating the heart.

Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue

The present invention provides an apparatus and a method for producing a virtual electrode within or upon a tissue to be treated with radio frequency alternating electric current. An apparatus in accordance with the present invention includes a supply of a conductive or electrolytic fluid to be provided to the patient, an alternative current generator, and a processor for creating, maintaining and controlling the ablation process by the interstitial or surficial delivery of the fluid to a tissue and the delivery of electric power to the tissue via the virtual electrode. The method in accordance with the invention includes the steps of delivering a conductive fluid to a predetermined tissue ablation site for a predetermined time period, applying a predetermined power level of radio frequency current to the tissue, monitoring at least one of several parameters and adjusting either the applied power and/or the fluid flow in response to the measured parameters.