Method of reducing friction between syringe components

A method of making a syringe assembly includes providing a first syringe component defining a first sliding surface that is substantially free of lubricant. The first sliding surface is contacted with water. The first sliding surface and the water in contact with the first sliding surface are heated at a temperature of at least 121° C. The first sliding surface is dried.

Fluoropolymer barrier materials for containers

A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners.

Fluoropolymer Barrier Materials For Containers

A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners. 1. A syringe stopper comprising:an elastomeric body; anda densified expanded fluoropolymer positioned on said elastomeric body.2. The syringe stopper of claim 1 , wherein said densified expanded fluoropolymer is densified expanded polytetrafluoroethylene.3. The syringe stopper of claim 1 , wherein said elastomeric body is comprised of a rubber constructed of butyl claim 1 , bromobutyl claim 1 , chlorobutyl claim 1 , silicone claim 1 , nitrile claim 1 , styrene butadiene claim 1 , polychloroprene claim 1 , ethylene propylene diene claim 1 , fluoroelastomers and blends thereof.4. The syringe stopper of claim 1 , wherein said densified expanded fluoropolymer has a thickness from 0.5 microns to 20 microns.5. The syringe stopper of claim 1 , wherein said densified expanded fluoropolymer is pre-treated with at least one treatment selected from chemical etching claim 1 , plasma treating claim 1 , corona claim 1 , and physical modification.6. The syringe stopper of claim 1 , wherein said densified expanded fluoropolymer is post-treated with at least one treatment selected from chemical etching claim 1 , plasma treating claim 1 , corona claim 1 , physical modification.7. The syringe stopper of claim 1 , further comprising a plurality of barrier polymers positioned on said densified expanded fluoropolymer layer.8. A syringe comprising the syringe stopper of .9. The syringe of claim 8 , wherein said syringe is free of lubricant.10. A syringe stopper comprising:an elastomeric body;an expanded fluoropolymer positioned on said elastomeric body; anda barrier polymer at least partially imbibed ...

METHOD OF REDUCING FRICTION BETWEEN SYRINGE COMPONENTS

A method of making a syringe assembly includes providing a first syringe component defining a first sliding surface that is substantially free of lubricant. The first sliding surface is contacted with water. The first sliding surface and the water in contact with the first sliding surface are heated at a temperature of at least 121° C. The first sliding surface is dried. 1. A component of a syringe assembly having a glass sliding surface that is prepared for sliding engagement with a second , complementary component of the syringe assembly by a process for reducing friction of the glass sliding surface , the process comprising:contacting the glass sliding surface with WFI;applying saturated stem to heat the glass sliding surface and the WFI in contact with the glass sliding surface; anddrying the glass sliding surface.2. The component of claim 1 , wherein the component is a glass syringe barrel and the glass sliding surface is an interior surface of the glass syringe barrel.3. The component of claim 2 , wherein the process for reducing friction of the glass sliding surface further comprises:rinsing the glass syringe barrel with a solvent following drying the glass sliding surface; anddrying the glass sliding surface at or above 90° C. after rinsing the glass syringe barrel with the solvent.4. The component of claim 2 , wherein the process for reducing friction of the glass sliding surface includes filling the glass syringe barrel with the WFI to contact the glass sliding surface with the WFI and further wherein the glass sliding surface is substantially free of lubricant prior to filling the glass syringe barrel with the WFI.5. The component of claim 1 , wherein the process for reducing friction of the glass sliding surface includes the glass sliding surface being substantially free of silicone oil prior to contacting the glass sliding surface with WFI.6. The component of claim 1 , wherein the glass sliding surface comprises borosilicate glass.7. The component of ...

Silicone Free Drug Delivery Devices

A pre-filled syringe having containing therein at least one therapeutic is provided. The syringe contains a silicone free barrel and an elastomeric syringe stopper that is covered with an expanded polytetrafluoroethylene barrier layer. The presence of a barrier layer that is at least partially porous on the outside of the syringe stopper improves the seal between the stopper and syringe barrel and minimizes the sliding force. In some embodiments, the barrel is formed of a glass material such as a borosilicate glass, that is free of silicone or other lubricants. 1. A pre-filled syringe comprising:a silicone free syringe barrel containing at least one therapeutic; andan elastomeric syringe stopper covered with an expanded polytetrafluoroethylene layer,wherein said expanded polytetrafluoroethylene layer is in contact with said syringe barrel, andwherein the syringe stopper has a slide force less than 15 N on said barrel.2. The pre-filled syringe of claim 1 , wherein said therapeutic comprises at least one bioactive selected from Coagulation Factors claim 1 , Cytokines claim 1 , Epigenetic protein families claim 1 , Growth Factors claim 1 , Hormones claim 1 , Peptides claim 1 , Signal Transduction molecules claim 1 , Vaccines claim 1 , and combinations thereof.3. The pre-filled syringe of claim 1 , wherein said therapeutic comprises at least one bioactive selected from Antibodies claim 1 , Antisense claim 1 , RNA interference claim 1 , Target receptors.4. The pre-filled syringe of claim 1 , wherein said therapeutic comprises mutations of a bioactive selected from Coagulation Factors claim 1 , Cytokines claim 1 , Epigenetic protein families claim 1 , Growth Factors claim 1 , Hormones claim 1 , Peptides claim 1 , Signal Transduction molecules claim 1 , Vaccines claim 1 , and combinations thereof.5. The pre-filled syringe of claim 1 , wherein said therapeutic comprises at least one bioactive selected from Protein Kinases claim 1 , Esterases claim 1 , Phosphatases claim 1 , ...

Syringe stopper coated with expanded PTFE

A syringe stopper that is suitable for use in syringes without silicone oil or other liquid lubricants. The invention provides a low friction barrier (20) between an elastomeric stopper material (10) and a therapeutic in the syringe. The barrier may inhibit materials from leaching from the elastomer material or from extraction of compounds from medicants by the elastomer. A process is also described that allows for molding thin barrier layers while allowing adequate bonding with the elastomer.

Fluoropolymer Barrier Materials for Containers

A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners. 1. A molded article comprising:a. a support, i. a densified expanded fluoropolymer layer,', 'ii. a thermoplastic layer adjacent to the densified expanded fluoropolymer layer, and', 'iii. an porous expanded fluoropolymer layer,, 'b. a barrier layer adjacent to the support, the barrier layer comprisingwherein the barrier layer has a maximum shape factor greater than 1.5.2. The molded article of having a maximum shape factor of greater than 3.0.3. The molded article of having a maximum shape factor of greater than 4.0.4. A molded article comprising:a. a support i. an interior space and an exterior space,', 'ii. an edge defining the boundary between the interior space and the exterior space, the edge having a major diameter, and', 'iii. a cross section perimeter length defined by a cross section of the barrier layer, 'b. a barrier layer adjacent to the support, the barrier layer comprising a densified expanded fluoropolymer layer, a thermoplastic layer adjacent to the densified expanded fluoropolymer layer, and a porous expanded fluoropolymer layer adjacent to the thermoplastic layer, the barrier layer having a shape, the shape definingwherein the ratio of the cross section perimeter to the major diameter is greater than 1.5.5. The molded article of in which the support comprises thermoplastic.6. The molded article of in which the support comprises thermoset.7. The molded article of in which the support comprises metal.8. The molded article of in which the support comprises ceramic.9. The molded article of in which the support comprises glass.10. A molded article comprising:a. a ...

METHOD OF REDUCING FRICTION BETWEEN SYRINGE COMPONENTS

A method of making a syringe assembly includes providing a first syringe component defining a first sliding surface that is substantially free of lubricant. The first sliding surface is contacted with water. The first sliding surface and the water in contact with the first sliding surface are heated at a temperature of at least 121° C. The first sliding surface is dried. 1. A method of reducing friction on glass comprising the steps of:a. providing a glass surface,b. contacting the glass surface with WFI water,c. applying saturated steam at a temperature of at least 121° C. to heat the glass surface and the WFI water, andd. drying the glass surface.2. The method of in which the drying step is performed at above 90° C.3. The method of in which the drying step is performed at room temperature.4. The method of further comprising the steps of:rinsing the glass surface with a solvent following the drying step; anddrying the glass surface at or above 90° C. following the rinsing step.5. The method of in which the glass surface comprises borosilicate glass.6. The method of further comprising the step of rinsing the glass surface with an organic solvent.7. The method of in which the rinsing step is performed prior to the drying step.8. The method of in which the organic solvent is hexane.9. The method of in which the glass surface that is provided is substantially free of lubricant prior to contacting the glass surface with WFI water.10. The method of in which the glass surface that is provided is substantially free of silicone oil prior to contacting the glass surface with WFI water.11. A method of making a syringe assembly comprising:providing a first syringe component defining a first sliding surface that is substantially free of lubricant;contacting the first sliding surface with water;heating the first sliding surface and the water in contact with the first sliding surface at a temperature of at least 121° C.; anddrying the first sliding surface.12. The method of in ...

Method Of Reducing Friction Between Syringe Components

A method of making a syringe assembly includes providing a first syringe component defining a first sliding surface that is substantially free of lubricant. The first sliding surface is contacted with water. The first sliding surface and the water in contact with the first sliding surface are heated at a temperature of at least 121° C. The first sliding surface is dried. 1. A method of treating a syringe assembly comprising:providing a glass barrel having a glass sliding surface for sliding engagement with a complementary component of a syringe assembly;applying saturated steam to heat the glass sliding surface;maintaining the saturated steam at a temperature at or above 120° C. for at least 60 minutes; anddrying the glass sliding surface,wherein a friction force of the glass sliding surface is reduced.2. The method of claim 1 , wherein the glass sliding surface is an interior surface of the glass barrel.3. The method of claim 2 , wherein the glass sliding surface is substantially free of silicone oil.4. The method of claim 1 , wherein the method is achieved within a sterilization cycle.5. The method of claim 1 , wherein the glass sliding surface is dried at about 90° C. or greater.6. The method of claim 1 , comprising rinsing the glass sliding surface with an organic solvent.7. The method of claim 1 , wherein the complementary component is a syringe stopper or a syringe tip cap.8. The method of claim 1 , wherein the glass barrel contains therein water for injection.9. The method of claim 7 , comprising removing the water for injection prior to the drying.10. The method of claim 1 , comprising placing the barrel into an autoclave prior to the application of saturated steam. Syringes used for delivery of medicaments are principally constructed of a barrel and a stopper. The stopper is slidably fitted within the syringe barrel and may have a stopper rod affixed to it for actuation of the syringe and delivery of medicament. The stopper is generally constructed of an ...

Fluoropolymer barrier materials for containers

A syringe stopper comprising an elastomeric body and an expanded fluoropolymer positioned on the elastomeric body. 4907994_1 (GHMatters) P95577.AU so 30 41 FIG. 5 FIG. 6 FIG. 7 FIG. 8

Method of reducing friction between syringe components

A component of a syringe assembly that is prepared for sliding engagement with a second, complementary component of the syringe assembly by a process comprising contacting the first sliding surface with WFI water, applying saturated steam to heat the first sliding surface and the WFI water in contact with the first sliding surface and drying the first sliding surface.

Fluoropolymer barrier materials for containers

A syringe stopper comprising an elastomeric body and an expanded fluoropolymer positioned on the elastomeric body. 4907994_1 (GHMatters) P95577.AU 4/10 40 30 so 30 41 20 FIG. 5 FIG. 6 30 4F FIG. 7 FIG. 8

Syringe stopper coated with expanded ptfe

A syringe stopper that is suitable for use in syringes without silicone oil or other liquid lubricants. The invention provides a low friction barrier (20) between an elastomeric stopper material (10) and a therapeutic in the syringe. The barrier may inhibit materials from leaching from the elastomer material or from extraction of compounds from medicants by the elastomer. A process is also described that allows for molding thin barrier layers while allowing adequate bonding with the elastomer.

Fluoropolymer barrier materials for containers

A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from teaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners.

Syringe stopper coated with expanded ptfe

Syringe stopper coated with expanded PTFE

A syringe stopper that is suitable for use in syringes without silicone oil or other liquid lubricants. The invention provides a low friction barrier (20) between an elastomeric stopper material (10) and a therapeutic in the syringe. The barrier may inhibit materials from leaching from the elastomer material or from extraction of compounds from medicants by the elastomer. A process is also described that allows for molding thin barrier layers while allowing adequate bonding with the elastomer.

Syringe cap coated with expanded ptfe

A tip cap for a syringe is provided, together with a syringe containing such a tip cap. The tip cap comprises an elastomer body and a barrier film, wherein the barrier film comprises an expanded fluoropolymer. The tip cap may provide a protective covering to a syringe needle. The barrier may inhibit materials from leaching from the elastomer material or from extraction of compounds from medicants by the elastomer. The tip cap is also readily removable.

Fluoropolymer barrier materials for containers

A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners. 8962884 1 (GHMatters) P95577.AU.2 19-Aor-17 4'4 FIG. 7 FIG. 8

Fluoropolymer barrier materials for containers