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30-05-2013 дата публикации

COMPOSITIONS FOR ENHANCING NAIL GROWTH

Номер: US20130136707A1
Принадлежит: ALLERGAN, INC.

The present invention is directed to compositions and methods for stimulating the growth of nails and cuticles in a mammal, including humans. The compositions may be administered topically to the nail bed, nail matrix and cuticle in an amount effective to increase nail growth and thicken, strengthen and smooth the nail. The composition is also effective in strengthening and growing nails, including fingernails and toenails. 1. A method of accelerating nail growth , treating brittle nails and strengthening nails in a human or animal , the method comprising:applying an oil-in-water emulsion to the nails, cuticles or nail matrix of the human or animal at least once a day, wherein said emulsion comprises cyclosporine A.2. The method of wherein the oil is castor oil and the emulsion further comprises the surfactant polysorbate 80.3. The method of further comprising glycerine.4. The method of wherein the oil is selected from the group consisting of: Anise oil; Castor oil; Clove oil; Cassia oil; Cinnamon oil; oils having a specific gravity between 0.90 and 0.95; Almond oil; Corn oil; Arachis oil; Cottonseed oil; Safflower oil; Maize oil; Linseed oil; Rapeseed oil; Soybean oil; Olive oil; Caraway oil; Rosemary oil; Peanut oil; Peppermint oil; Sunflower oil; Eucalyptus oil; Sesame oil; an oil having a specific gravity specific gravity below 0.9; Mineral oil; Coriander oil; Lavender oil; Citronella oil; Juniper oil; Lemon oil; Orange oil; Clary sage oil; Nutmeg oil; and Tea tree oil or mixtures thereof.5. The method of wherein the oil-in-water emulsion further contains a surfactant selected from the group consisting of Polysorbate 80 claim 1 , carboxylated and ethoxylated alcohols claim 1 , amine oxides claim 1 , block polymers claim 1 , fatty acids including carboxylic fatty acids claim 1 , ethoxylated alkyl phenols claim 1 , ethoxylated fatty esters claim 1 , glycerol esters claim 1 , lanolin-based derivatives claim 1 , lignin derivatives claim 1 , methyl esters claim 1 , ...

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13-06-2013 дата публикации

CYCLOSPORINE COMPOSITIONS FOR ENHANCING NAIL GROWTH

Номер: US20130149267A1
Принадлежит: ALLERGAN, INC.

The present invention is directed to cyclosporine compositions and methods for stimulating the growth of nails and cuticles in a mammal, including humans. The compositions may be administered topically to the nail bed, nail matrix and cuticle in an amount effective to increase nail growth and thicken, strengthen and smooth the nail. The composition is also effective in strengthening and growing nails, including fingernails and toenails. 1. A method of accelerating nail growth , treating brittle nails or strengthening nail growth in a human or animal , the method comprising:topically applying a composition comprising cyclosporine to the nails, cuticles or nail matrix of the human or animal at least once a day, wherein said composition is selected from the group consisting of an emulsion, solution, gel, paste, dispersion and suspension.2. The method of wherein the cyclosporine is cyclosporine A.3. The method of wherein the cyclosporine is a cyclosporine A derivative or segment.4. The method of wherein the composition is an emulsion.5. The method of wherein the cyclosporine is cyclosporine A and is present in the emulsion in the amount of 0.05% w/v.6. The method of claim 5 , further comprising glycerin claim 5 , castor oil claim 5 , polysorbate 80 and carbomer 1342.7. The method of where in the cyclosporine is cyclosporine A and is present in a solution in the amount 0.01% w/v to 0.0125% w/v of the composition.8. The method of wherein the cyclosporine is present in the amount of 0.001% w/v to 50% w/v of the composition. This application is a divisional of U.S. application Ser. No. 12/683,811 filed Jan. 7, 2010, which claims the benefit of U.S. Provisional Application Ser. No. 61/143,317, filed Jan. 8, 2009; U.S. Provisional Application Ser. No. 61/181,353, filed May 27, 2009; U.S. Provisional Application Ser. No. 61/181,165 filed May 26, 2009; and, U.S. Provisional Application Ser. No. 61/160,946 filed Mar. 17, 2009 each of which is hereby incorporated by reference in ...

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