15-10-2020 дата публикации
Номер: US20200323617A1
Принадлежит:
The present disclosure provides tissue fillers. The tissue fillers can include a plurality of tissue particles formed from acellular tissue matrix fragments. The tissue fillers can be used to fill tissue sites, such as voids formed after tissue resection. 1. A tissue product , comprising:a plurality of dry tissue matrix particles that form a flowable mass configured to fill and conform to a tissue site, wherein the particles have a radius between about 1 mm and 5 mm, wherein the tissue matrix particles each comprise a plurality of tissue matrix fragments having a length between about 5 μm and 300 μm, and wherein the tissue matrix fragments are joined to one another to form the tissue matrix particles.2. The tissue product of claim 1 , wherein the tissue matrix particles include dermal tissue matrix particles.3. The tissue product of claim 1 , wherein the tissue matrix particles include porcine tissue matrix particles.4. The tissue product of claim 1 , wherein the particles swell when contacted with water.5. The tissue product of claim 1 , wherein the particles are substantially spherical.6. The tissue product of claim 1 , wherein the particles are configured to fill a void or pocket in a tissue site.7. The tissue product of claim 1 , wherein the particles are dried.8. The tissue product of claim 7 , wherein the particles are freeze-dried.9. The tissue product of claim 7 , wherein the particles are dried by a dehydrothermal cross-linking process.10. The tissue product of claim 7 , wherein the particles are concurrently freeze-dried and treated with a dehydrothermal cross-linking process.11. The tissue product of claim 1 , wherein the fragments are formed into particles by joining the fragments without use of a binder or adhesive.12. The tissue product of claim 11 , wherein the fragments are joined by convective drying.13. The tissue product of claim 1 , wherein the particles each have a length between about 2 mm and 3 mm.14. The tissue product of claim 1 , wherein ...
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