Therapeutic polyamine compositions and their synthesis

This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicity of neurotoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be utilized to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure. 1. A method of treating degenerative diseases due to acquired mitochondrial DNA damage , redox damage to mitochondrial macromolecules and inherited mitochondrial genetic defects said method comprising the steps of:selecting a composition from a group consisting of predominantly linear tetraamines and polyamines linked by 1,3-propylene and/or ethylene groups, predominately branched tetraamines and polyamines linked by 1,3-propylene and/or ethylene groups, cyclic polyamines linked by 1,3-propylene and/or ethylene groups, combinations of linear, branched and cyclic polyamines linked by one or more 1,3-propylene and/or ethylene groups, substituted polyamines, polyamines derivatized to form tyrosine phosphatase inhibitor molecules with linear or branched chains attached, polyamine derivatives of 2,2′-diaminobiphenyl with linear or branched chains ...

Method and apparatus for detecting and reporting a power outage

A method and apparatus for detecting a power outage within an energy meter a nd alerting a remote central computer about the outage using call-in reporting via modem (35) within the meter to a telephone numbe r designated for outage reporting. A primary battery cell or pack (55) is placed inside the meter (40) to operate the modem (35) when lin e power is lost. The modem (35) switches from a line power source in the meter (40) to the battery source (55) when an outage is detect ed and is to be reported to the remote central computer as an outage call. The battery source (55) is switched off when the outage is completed or aborted. The number of retries to call to report the power outage and the time period between retries is programmable.

Water-based cleaner for cleaning solvent-based paints

A “water-in-oil emulsion” comprising a solvent or solvent blend; water; an emulsifier; optionally an emulsion stability additive, such as a surfactant, preferably anionic and optionally a paint compatibility additive, such as esters, ketones, alcohols.

Water-based cleaner for cleaning solvent-based paints.

La invención se refiere a una emulsión de aceite en agua que comprende un solvente o una mezcla de solventes; agua; un emulsificante; opcionalmente un auxiliar estabilizante de la emulsión, como un tensoactivo, de preferencia aniónico, y opcionalmente un auxiliar de compatibilidad con pinturas, como un éster, una cetona o un alcohol.

A system and method for detecting tampering of a utility meter

A tamper alarm circuit for detecting a tampered condition of a utility meter is disclosed. The tamper alarm circuit has a transducer coupled to an amplification circuit which is coupled to a detection circuit, the detection circuit generating an alarm condition when the detection circuit determines that a voltage signal generated by the transducer and amplified by the amplification circuit has reached a predetermined threshold.

Polyamine treatment of neurological disorders

2,3,2 Tetramine (3,7-diazanonane-1,9-diamine) is propounded for the treatmen t of Parkinson's Disease and demential characterized by mitochondrial damage in view of this compound's ability to completely neutralize the dopamine-depriving effect of MPTP in laboratory animals up to 12 hours post MPTP injection, and to retain partial protection at suboptimal tissue levels for up to 36 hours. The effect of injecting combinations of MPTP and/or reducing agents and/or xenobiotics and/or depigmenting agents on Dopamine, Norepinephrine, Serotonin and Epinephrine levels demonstrated that MPTP and MPP+ act as reducing agents that mobilize copper and calcium, and sequester iron, and that the vulnerability of dopaming to these types of neurotoxins a nd to xenobiotics and metals can be corrected by administration of 2,3,2 tetramine that appears to redistribute metals between diverse stora ge pools and free metals in cytosol and regulate receptor mediated events, among other antidotal effects analogous to those of some of the endogenous polyamines.

Composition and process for treating metal surfaces

A metal substrate is provided with a coating that (i) provides substantial corrosion resistance, (ii) makes it possible to shape the substrate by roll forming and similar light cold forming operations without the need for any oil or wax lubricant, and (iii) has good adhesion to subsequently applied paint. This is achieved by coating the metal substrate surface with an aqueous liquid composition that contains acrylate polymer resin, wax, and hexavalent chromium and then drying this coating into place on the surface to produce the desired dry coating.

Water-based cleaner for cleaning solvent-based paints

A "water-in-oil emulsion" comprising a solvent or solvent blend; water; an emulsifier; optionally an emulsion stability additive, such as a surfactant, preferably anionic and optionally a paint compatibility additive, such as esters, ketones, alcohols.

Water-based flushing solution for paints and other coatings

This invention relates to cleaning compositions for removing paint and other coatings from surfaces and methods of making and using the cleaning compositions.

Telecommunications off-hook and intrusion detection method and apparatus

A method and apparatus to detect off-hook and intrusion conditions on a telephone line. A voltage to frequency converter is used to convert the voltage measured between the TIP and RING terminals of a telephone line to a frequency. The voltage is continuously monitored, once during each sample period. The measured frequency is compared to predetermined threshold values to determine the state of the telephone line. The predetermined threshold values are updated in each sample period.

Composition, synthesis and therapeutic applications of polyamines

This invention relates to a process of synthesis and composition of open cha in (ring), closed ring, linear branched and or substituted polyamines, polyamin e derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines preve nt the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxa n. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

Composition, synthesis and therapeutic applications of polyamines

This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

Electroceramic coating for magnesium alloys

This invention relates to articles having magnesium-containing metal surfaces with an electroceramic coating chemically bonded to the metal surfaces and to articles having a composite coating comprising first sectors of electroceramic coating and second sectors comprising organic and/or inorganic components different from the electroceramic coating. The invention further relates to processes of making and using the articles.

Transient protector circuit for multi-phase energized power supplies

Circuits and systems are used in multi-phase power supplies for the prevention of transient currents. Phase to phase and phase to neutral metal oxide varistors ('MOV') are replaced with a single DC power supply connected MOV. Transient currents are limited by resistors that are connected in series to each of the three phase inputs. Comprising a single DC connected MOV, protection from transients between any of the four inputs is provided. The phase to phase and the phase to neutral transient currents are routed, using diodes, through a single MOV connected between the positive and negative input terminals of the DC power supply.

Polyamin-behandlung von neurologischen störungen