27-02-2020 дата публикации
Номер: US20200061071A1
Принадлежит:
The application relates to a compound of Formula (I): 2. The method of claim 1 , wherein the mutant BTK comprises a drug-resistant mutation.3. The method of claim 2 , wherein the drug-resistant mutation is a mutation at amino acid 481.4. The method of claim 2 , wherein the drug-resistant mutation is C481S.5. The method of claim 1 , wherein the cancer is resistant to a BTK inhibitor.6. The method of claim 5 , wherein the BTK inhibitor is ibrutinib.7. The method of claim 1 , wherein the cancer is selected from a cancer of the breast claim 1 , ovary claim 1 , cervix claim 1 , prostate claim 1 , testis claim 1 , esophagus claim 1 , larynx claim 1 , stomach claim 1 , skin claim 1 , lung claim 1 , bone claim 1 , pancreas claim 1 , colon claim 1 , thyroid claim 1 , biliary passage claim 1 , hairy cells claim 1 , buccal cavity claim 1 , naso-pharyngeal claim 1 , lip claim 1 , tongue claim 1 , mouth claim 1 , large intestine claim 1 , small intestine claim 1 , colon-rectum claim 1 , rectum claim 1 , brain and central nervous system claim 1 , bronchus claim 1 , liver claim 1 , intrahepatic bile duct claim 1 , urinary bladder claim 1 , uterine corpus claim 1 , kidney claim 1 , renal pelvis claim 1 , oral cavity claim 1 , pharynx claim 1 , glioblastoma claim 1 , neuroblastoma claim 1 , keratoacanthoma claim 1 , epidermoid carcinoma claim 1 , large cell carcinoma claim 1 , non-small cell lung carcinoma (NSCLC) claim 1 , small cell carcinoma claim 1 , lung adenocarcinoma claim 1 , adenoma claim 1 , adenocarcinoma claim 1 , follicular carcinoma claim 1 , undifferentiated carcinoma claim 1 , papillary carcinoma claim 1 , seminoma claim 1 , melanoma claim 1 , sarcoma claim 1 , bladder carcinoma claim 1 , liver carcinoma claim 1 , kidney carcinoma claim 1 , myeloid disorders claim 1 , lymphoma claim 1 , Hodgkin's leukemia claim 1 , hepatocellular cancer claim 1 , glioma claim 1 , endometrial cancer claim 1 , multiple myeloma claim 1 , acute myelogenous leukemia claim 1 , chronic ...
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