AQUEOUS CONTRAST AGENTS FOR DYNAMIC MRI AND MRA

In a first aspect this invention provides methods comprising administering an aqueous contrast agent to the vascular system of a subject, and performing a magnetic resonance scan to detect the MR signal enhancement effects of the aqueous contrast agent. In embodiments the magnetic resonance scan comprises applying at least one pulse sequence selected from a PD-weighted pulse sequence, a T1-weighted pulse sequence, a T2-weighted pulse sequence, and a D-weighted pulse sequence. In embodiments the magnetic resonance scan comprises applying a T1-weighted pulse sequence. A system for performing perfusion MRI comprising an aqueous contrast solution and an injection apparatus configured to provide a maximum injection rate of the aqueous contrast solution to a subject vascular system of at least about 5 ml/s. is also provided. 1. A method comprising:administering an aqueous contrast agent to the vascular system of a subject, and{'sub': 1', '2, 'performing a magnetic resonance scan to detect the MR signal enhancement effects of the aqueous contrast agent, wherein the magnetic resonance scan comprises applying at least one pulse sequence selected from a PD-weighted pulse sequence, a T-weighted pulse sequence, a T-weighted pulse sequence, and a D-weighted pulse sequence.'}2. The method of claim 1 , wherein the magnetic resonance scan comprises applying a T-weighted pulse sequence.3. The method of claim 2 , wherein the magnetic resonance scan further comprises applying at least one pulse sequence selected from a PD-weighted pulse sequence claim 2 , a T-weighted pulse sequence claim 2 , and a D-weighted pulse sequence.4. The method of claim 1 , further comprising comparing the MR signals at a first period with the MR signals at a second period claim 1 , wherein the first and second periods are different and are selected from before administration of the aqueous contrast agent claim 1 , during administration of the aqueous contrast agent claim 1 , and after administration of the ...