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Применить Всего найдено 7. Отображено 7.
06-12-2016 дата публикации

Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Номер: US0009512161B2
Автор: James D. Rodgers, Adam Shilling, Argyrios G. Arvanitis, Stacey Shepard, Laurine G. Galya, Mei Li, Frank M. Nedza, RODGERS JAMES D, SHILLING ADAM, ARVANITIS ARGYRIOS G, SHEPARD STACEY, GALYA LAURINE G, LI MEI, NEDZA FRANK M, Rodgers James D., Shilling Adam, Arvanitis Argyrios G., Shepard Stacey, Galya Laurine G., Li Mei, Nedza Frank M.
Принадлежит: Incyte Corporation, Incyte Holdings Corporation, INCYTE CORP, INCYTE HOLDINGS CORP

The present invention provides hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile.

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Номер записи: 1
18-07-2012 дата публикации

Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Номер: CN102596960A
Автор: Rodgers James D, Shilling Adam, Arvanitis Argyrios G, Shepard Stacey, Galya Laurine G, Li Mei, Nedza Frank M.
Принадлежит:

The present invention provides hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile.

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Номер записи: 2
26-12-2013 дата публикации

HYDROXYL, KETO, AND GLUCURONIDE DERIVATIVES OF 3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE

Номер: US20130345157A1
Автор: Arvanitis Argyrios G., Galya Laurine G., Li Mei, Nedza Frank M., Rodgers James D., Shepard Stacey, Shilling Adam
Принадлежит: INCYTE CORPORATION

The present invention provides hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile. 28-. (canceled)12. A compound of claim 1 , which is:6-(3-(1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-2-cyanoethyl)cyclopentyloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acidor a pharmaceutically acceptable salt of any of the aforementioned.13. A compound of claim 1 , selected from:6-(1-(1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-2-cyanoethyl)cyclopentyloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid;6-(1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-2-cyano-1-cyclopentylethoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid;6-(2-(1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-2-cyanoethyl)cyclopentyloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid;6-(2-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-cyano-2-cyclopentylethoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; and6-(3-(1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-2-cyanoethyl)cyclopentyloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid;or a pharmaceutically acceptable salt of any of the aforementioned.14. A compound which is:6-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acidor a pharmaceutically acceptable salt of any of the aforementioned.15. A compound selected from:6-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid;6-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-6-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid;6-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; and6-(4-(1-(2-cyano-1-cyclopentylethyl)-1H- ...

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Номер записи: 3
25-12-2014 дата публикации

HYDROXYL, KETO, AND GLUCURONIDE DERIVATIVES OF 3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE

Номер: US20140378400A1
Автор: Arvanitis Argyrios G., Galya Laurine G., Li Mei, Nedza Frank M., Rodgers James D., Shepard Stacey, Shilling Adam
Принадлежит:

The present invention provides hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile. 118-. (canceled)19. A method of using (3R) 3-cyclopentyl-3-[4-(7H-pyrrolo[2 ,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphoric acid salt for the treatment of a myeloproliferative disorder , to administer at least one metabolite to a patient in need thereof , comprising administering (3R) 3-cyclopentyl-3-[4-(7H-pyrrolo[2 ,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphoric acid salt to a patient in need thereof , wherein said metabolite is not selected from:3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(3-hydroxycyclopentyl)propanenitrile; or3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(2-hydroxycyclopentyl)propanenitrile; or3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(3-oxocyclopentyl)propanenitrile.20. The method of claim 19 , wherein the myeloproliferative disorder is polycythemia vera (PV).21. The method of claim 19 , wherein the myeloproliferative disorder is essential thrombocythemia (ET).22. The method of claim 19 , wherein the myeloproliferative disorder is myeloid metaplasia with myelofibrosis (MMM).24. The method of claim 23 , wherein:the carbon atom alpha to the cyano group of said metabolite is not replaced with a C—OH or C═O group; andthe carbon atom beta to the cyano group of said metabolite is not replaced with a C—OH group.25. The method of claim 23 , wherein n C—H groups are each independently replaced with C—OH.26. The method of claim 23 , wherein n is 1.27. The method of claim 23 , wherein n is 2.28. The method of claim 23 , wherein n is 3.29. The method of claim 23 , wherein n is 4.30. The method of claim 23 , wherein one CHgroup is independently replaced with a C═O.34. The method of claim 23 , wherein said metabolite is selected from:6-(3-(1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-2-cyanoethyl)cyclopentyloxy)-3,4 ...

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Номер записи: 4
04-10-2022 дата публикации

3-(4-(7H-PYROLO[2,3-D]PYRIMIDIN-4-IL)-1H-PYRAZOL-1-IL)-3-CYCLOPENTYLPROPANONITRILE 3-(4-(7H-PYROXYL, KETO, AND GLUCURONIDE) DERIVATIVES

Номер: BR112012008267B1
Автор: Adam SHILLING, Argyrios G. Arvanitis, Frank M. Nedza, James D. Rodgers, Laurine G. Galya, Mei Li, Stacey Sherpard
Принадлежит: Incyte Holdings Corporation

DERIVADOS HIDROXIL, CETO E GLICURONIDA DE 3-(4(7H-PIRROLO[2,3-D]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-3-CICLO-PENTILPROPANONITRILA. A presente invenção fornece derivados hidroxil, ceto e glicuronida de 3-(4-7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)3-ciclopentilpropanonitrila. 3-(4(7H-PYROLO[2,3-D]PYRIMIDIN-4-IL)-1H-PYRAZOL-1-IL)-3-CYCLO-PENTYLPROPANENITRILE HYDROXYL, KETO AND GLUCURONIDE DERIVATIVES. The present invention provides hydroxyl, keto and glucuronide derivatives of 3-(4-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)3-cyclopentylpropanenitrile.

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Номер записи: 5
14-04-2011 дата публикации

Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Номер: WO2011044481A1
Автор: Adam SHILLING, Argyrios G. Arvanitis, Frank M. Nedza, James D. Rodgers, Laurine G. Galya, Mei Li, Stacey Shepard
Принадлежит: INCYTE CORPORATION

The present invention provides hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile.

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Номер записи: 6
14-04-2011 дата публикации

HYDROXYL, KETO, AND GLUCURONIDE DERIVATIVES OF 3-(4-(7H-PYRROLO[2,3-d] PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE

Номер: US20110086810A1
Автор: Adam SHILLING, Argyrios G. Arvanitis, Frank M. Nedza, James D. Rodgers, Laurine G. Galya, Mei Li, Stacey Shepard
Принадлежит: Incyte Corp

The present invention provides hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile.

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Номер записи: 7