Targeting of chondroitin sulfate glycans

The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA).

Targeting of chondroitin sulfate glycans

The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA).

TARGETING OF CHONDROITIN SULFATE GLYCANS

The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA). 1. A method for the isolation and/or detection of cells expressing CD44 , and/or CSPG4 , and/or any other proteoglycan , such as a proteoglycan listed in Table 1 , such as cancer stem cells or circulating cancer cells (CTC) in a biological sample , said method comprising:a) obtaining a biological sample comprising cells expressing CD44 and/or CSPG4, and/or any other proteoglycan, such as proteoglycans listed in Table 1;b) contacting said biological sample with a VAR2CSA polypeptide, or a conjugate or fusion protein comprising a VAR2CSA polypeptide and a therapeutic or diagnostic effector moiety, such as a cytotoxic moiety, fluorescent label, and/or a radiolabel, optionally coupled to a solid support; andc) purifying, isolating and/or detecting the complexes of said cells expressing CD44, and/or CSPG4, and/or any other proteoglycan, such as a proteoglycan listed in Table 1 and said VAR2CSA polypeptide or conjugate.2. The method of claim 1 , wherein said VAR2CSA polypeptide is a fragment of VAR2CSA claim 1 , which fragment consist of a sequential amino acid sequence of ID1 claim 1 , and DBL2Xb claim 1 , and optionally ID2a.3. The method of claim 2 , which fragment comprises an amino acid sequence having at least 70% sequence identity with any one amino acid sequence of 1-577 of SEQ ID NO:1 claim 2 , 1-592 of SEQ ID NO:3 claim 2 , 1-579 of SEQ ID NO:4 claim 2 , 1-576 of SEQ ID NO:5 claim 2 , 1-586 of ...

TARGETING OF CHONDROITIN SULFATE GLYCANS

The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA). 1. A method for the treatment of any indication associated with expression , such as inappropriate expression of CSA , such as in cancer , arthritis , arthrosis , multiple sclerosis , pathological conditions caused by neural damage , conditions of the cartilage and scar tissue , such as in rheumatism , cartilage repair or wound healing , or in psoriasis; the method comprising administering a therapeutically or prophylactically effective amount of a VAR2CSA polypeptide , or a conjugate or fusion protein comprising a VAR2CSA polypeptide and a therapeutic or diagnostic effector moiety , such as a cytotoxic moiety , fluorescent label , and/or a radiolabel; to a subject in need thereof.2. A method for preventing the occurrence of an indication or condition associated with expression , such as inappropriate expression of CSA , such as in cancer , multiple sclerosis , arthritis , arthrosis , pathological conditions caused by neural damage , conditions of the cartilage and scar tissue , such as in rheumatism , cartilage repair or wound healing , or in psoriasis; the method comprising administering a therapeutically or prophylactically effective amount of a VAR2CSA polypeptide , or a conjugate or fusion protein comprising a VAR2CSA polypeptide and a therapeutic or diagnostic effector moiety , such as a cytotoxic moiety , fluorescent label , and/or a radiolabel; to a subject in need thereof.3. The method of ...

ROTATING PRISM SCANNING DEVICE AND METHOD FOR SCANNING

The present invention relates to a scanning device and a method for scanning. The scanning device comprises a first frame () supporting a first deflector (), and a second frame () supporting a second deflector (). The first frame is arranged for rotation around a first axis (), and the second frame is arranged for rotation around a second axis (). The first frame is rotatably connected to a base () for rotation around the first axis and the second frame is arranged for rotation around the first axis. The method for scanning comprises rotating the first frame around the first axis according to a first selected value, and rotating the second frame around the second axis according to a second selected value. 1. A scanning device comprisinga first frame supporting a first deflector for deflecting light, the first deflector having a first surface and a second surface, the first surface and the second surface forming a first deflector angle, the first frame being arranged for rotation around a first axis, the first axis forming a first surface angle with the first surface, anda second frame supporting a second deflector for deflecting light, the second deflector having a third surface and a fourth surface, the third surface and the fourth surface forming a second deflector angle, the second frame being arranged for rotation around a second axis, the second axis forming a frame angle with the first axis, forming a second surface angle with the second surface, and forming a third surface angle with the third surface,wherein the first frame being rotatably connected to a base for rotation around the first axis and the second frame being arranged for rotation around the first axis, the scanning device further comprisinga first drive coupled to the first frame for controlling the rotation of the first frame around the first axis, anda second drive coupled to the second frame for controlling the rotation of the second frame around the second axis, such that individual control ...

METHOD AND SYSTEM FOR VIDEO COLLECTION AND ANALYSIS THEREOF

A computer implemented method of performing video surveillance on a computer system, wherein the computer system comprises a video and a display with a graphical user interface, the graphical user interface including a source window to view play back of the video, the surveillance method comprising: determining an area of interest of a frame of the video based upon a selection of the area of interest within the source window, and generating a plurality of windows within the graphical user interface, each of the windows displaying the area of interest of the frame of the video at a point in time, wherein the graphical user interface includes controls to manipulate the playback of the video from a point in time relative to each displayed portion. 1. A computer implemented method of performing video surveillance on a computer system , wherein the computer system comprises a video and a display with a graphical user interface , the graphical user interface including a source window to view play back of the video , the surveillance method comprising:determining an area of interest of a frame of the video based upon a selection of the area of interest within the source window; andgenerating a plurality of windows within the graphical user interface, each of the windows displaying the area of interest of the frame of the video at a point in time, wherein the graphical user interface includes controls to manipulate the playback of the video from a point in time relative to each displayed portion.2. The method of claim 1 , wherein the step of generating includes the step of determining the point in time of at least one of the windows.3. The method of claim 2 , wherein the step of determining the point in time of at least one of the windows is based upon an input by a human operator.4. The method of claim 3 , wherein the windows generated by the generating step are representative of portions of the video displaced from one another by a pre-determined period of time.5. The ...

METHOD AND SYSTEM FOR RECEIVING SURVEILLANCE VIDEO FROM MULTIPLE CAMERAS

A video compositing device includes a communication device that communicates with a video receiver station over a network and receives video streams from various video sources. The compositing device stores configuration settings, which indicate the size, position, zoom and/or color depth for views in a composite image that is formed from the video streams. The compositing device uses the video streams to generate the composite image as indicated by the configuration settings and transmits the composite image to the video receiver station. The compositing module also receives from the video receiver station information indicating a change in one or more one of the size, position, zoom or color depth of a selected view in the composite image, and then updates the configuration settings to reflect these changes. Subsequent composited images are generated in accordance with the updated configuration settings. 1. A video system comprising a video receiver station , the video receiver station comprising:a central processing unit (“CPU”) to control operations of the video receiver station;networking hardware in communications with the CPU and configured to communicate with a remote device over a network;a user input device in communication with the CPU and configured to accept input from a user;a display in communications with the CPU; and utilizing the networking hardware to receive video information from the remote device, the video information comprising a plurality of views;', 'causing the display to generate an image corresponding to the received video information;', 'accepting input from the user input device to indicate a change to at least one of a size, position, zoom or color depth of a selected view in the video information; and', 'utilizing the networking hardware to transmit to the remote device information corresponding to the change to at least one of the size, position, zoom or color depth of the selected view., 'first memory in communications with the CPU ...

TARGETING OF CHONDROITIN SULFATE GLYCANS

The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA). 117-. (canceled)18. A conjugate or fusion protein comprising a VAR2CSA polypeptide , and a therapeutic or diagnostic effector moiety , such as a cytotoxic moiety , fluorescent label , and/or a radio label.19. The conjugate according to claim 18 , wherein the VAR2CSA polypeptide is or comprises a protein fragment consisting of a sequential amino acid sequence ofa) ID1, andb) DBL2Xb, and optionally ID2a.20Pseudomonas. The conjugate according to claim 18 , wherein the cytotoxic moiety is selected from calicheamycin claim 18 , auristatin claim 18 , doxorubicin claim 18 , maytansinoid claim 18 , taxol claim 18 , ecteinascidin claim 18 , geldanamycin claim 18 , methotrexate and their derivatives claim 18 , cytotoxic proteins such as exotoxin A claim 18 , diphtheria toxin claim 18 , ricin toxin claim 18 , pokeweed antiviral protein claim 18 , saporin claim 18 , gelonin and functional variants claim 18 , fragments claim 18 , and combinations thereof.2122-. (canceled)23. The conjugate according to claim 18 , wherein the therapeutic or diagnostic effector moiety is an anti-inflammatory agent.24. The conjugate according to claim 18 , wherein the therapeutic or diagnostic effector moiety is CSPG4 claim 18 , CD44 claim 18 , or other proteoglycans exemplified but not limited to those in Table 1.25. A composition comprising the conjugate according to .2632-. (canceled)33. A method for the treatment of any ...

VIRUS LIKE PARTICLE WITH EFFICIENT EPITOPE DISPLAY

The invention relates to a virus like particle (VLP) based vaccine. The virus-like particle constitutes a non-naturally occurring, ordered and repetitive antigen array display scaffold which can obtain a strong and long-lasting immune response in a subject. The VLP based vaccine may be used for the prophylaxis and/or treatment of a disease including, but is not limited to, cancer, cardiovascular, infectious, asthma, and/or allergy diseases/disorders. 1. A vaccine comprising:i. a papilloma virus (PV) L1 protein containing a biotin acceptor site, andii. a biotin molecule enzymatically conjugated to said biotin acceptor site, andiii. an antigen fused to a monovalent streptavidin,wherein the antigen and PV L1 protein are linked via the interaction between the monovalent streptavidin and the biotin molecule enzymatically conjugated to the biotin acceptor site of the PV L1 protein, and wherein i-iii form a virus like particle displaying said antigen.27.-. (canceled)8. The vaccine according to claim 1 , wherein the PV L1 protein is from a virus infecting mammals.9. The vaccine according to claim 1 , wherein the PV L1 protein is from the human PV genotype 16 and/or 118.10. The vaccine according to claim 1 , wherein the biotin acceptor site comprises amino acid sequence SEQ ID NO: 36.11. The vaccine according to claim 1 , wherein the biotin acceptor site is fused into a loop of the PV L1 protein claim 1 , the loop selected from the group consisting of: a DE-loop and an HI-loop of the PV L1 protein.12. The vaccine according to claim 1 , wherein the PV L1 protein containing the biotin acceptor site is a PV L1 protein derived from the human PV genotype 16 claim 1 , the PV 1 protein containing the biotin acceptor site having a PV L1 amino acid sequence wherein residues 134-137 (YAAN) are deleted compared to a wild-type PV L1 amino acid sequence claim 1 , and wherein the PV L1 protein contains the biotin acceptor site in a DE-loop at position 133/138 in the amino acid sequence of ...

Methods for Producing Diterpenes

The present invention discloses that by combining different di TPS enzymes of class I and class II different diterpenes may be produced including diterpenes not identified in nature. Surprisingly it is revealed that a di TPS enzyme of class I of one species may be combined with a di TPS enzyme of class II from a different species, resulting in a high diversity of diterpenes, which can be produced. 1. A method of producing a terpene , comprising: i. A heterologous nucleic acid encoding a diTPS of class II,', 'with the proviso that the diTPS of class II and the diTPS of class I are not from same species; and with the proviso that when the diTPS of class II is SsLPPS then the diTPS of class I is not CfTPS3, CfTPS4 or EpTPS8 and when the diTPS of class I is EpTPS8, then the diTPS of class II is not CfTPS2 or SsLPPS;', 'ii. A heterologous nucleic acid encoding a diTPS of class I,'}], '(a) providing a host organism comprising'}(b) incubating the host organism in the presence of geranylgeranyl pyrophosphate (GGPP) under conditions allowing growth of the host organism; andc) Optionally isolating diterpene from the host organism.2. The method of claim 1 , wherein the diterpene is a C-molecule containing a decalin core and up to 3 oxygen molecules.4. The method of claim 3 , wherein the diterpene is a C-molecule containing a cores structure of formula I claim 3 , II claim 3 , III claim 3 , IV claim 3 , V claim 3 , VI claim 3 , IX or X substituted at one or more positions by one or more groups comprising:(a) alkyl, wherein the alkyl is linear or branched;(b) alkenyl; and(c) hydroxyl.5. The method of claim 1 , wherein the diterpene is a C-molecule containing a decalin substituted at the 10 position with C-alkenyl chain claim 1 , a hydroxyl claim 1 , a methyl group and/or ═C.6. The method of claim 1 , wherein the diterpene is a C-molecule consisting of 20 carbon atoms claim 1 , with up to three oxygen atoms and hydrogen atoms claim 1 , wherein the molecule contains a core ...

A FLEXIBLE METAL TUBE

The present invention relates to flexible metal tube having a length and a longitudinal axis and suitable for forming a carcass of a flexible pipe for transport of hydrocarbons, the metallic tube comprises a plurality of consecutive windings of at least one elongate strip structure comprising a bearing structure and at least one cover flange. The cover flange is intended to cover the gaps which appear when the elongate strip is wound to form the flexible metal tube. When a fluid is flowing in the tube, open gaps may cause formation of vortexes in the flow of fluid which in most cases is undesired. 1. A flexible metal tube having a length and a longitudinal axis and suitable for forming a carcass of a flexible pipe for transport of hydrocarbons , the metal tube comprises a plurality of consecutive windings of at least one profiled structure of an elongate strip and comprising a bearing structure and at least one cover flange , said bearing structure comprises a first and a second laterally folded side part , said first laterally folded side part in said plurality of consecutive windings is interlocked with said second laterally folded side part in respective adjacent windings allowing adjacent windings to move laterally a limited distance d relative to each other thereby allowing a maximum lateral gap between the first and the second laterally folded side part in adjacent windings , wherein said cover flange is integrated with and extends from said bearing structure to cover said lateral gap and where only one layer of the elongate strip constitutes the bearing structure and where engaging layers of the elongate strip are able to slide in respect of each other in directions substantially parallel to the longitudinal axis and directions substantially perpendicular to the longitudinal axis.2. The flexible metal tube of claim 1 , wherein said cover flange extends from said bearing structure immediately adjacent to said first laterally folded side part in a first of said ...

VIRUS-LIKE PARTICLE WITH EFFICIENT EPITOPE DISPLAY

The invention relates to a virus-like particle (VLP) based vaccine. The virus-like particle constitutes a non-naturally occurring, ordered and repetitive antigen array display scaffold which can obtain a strong and long-lasting immune response in a subject. The VLP-based vaccine may be used for the prophylaxis and/or treatment of a disease including, but is not limited to, cancer, cardiovascular, infectious, chronic, neurological diseases/disorders, asthma, and/or immune-inflammatory diseases/disorders. 1. A vaccine for use in the prophylaxis and/or treatment of a disease wherein the vaccine comprises:i. a virus capsid protein comprising a first peptide tag, andii. an antigen fused to a second peptide tag,wherein the antigen and virus capsid protein are linked via an isopeptide bond between the first and second peptide tag, and wherein i-ii form a virus-like particle displaying said antigen.2. The vaccine according to claim 1 , wherein the first peptide tag comprises a SpyTag claim 1 , and wherein the second peptide tag comprises a SpyCatcher claim 1 , wherein the antigen and virus capsid protein are linked via the interaction between the SpyCatcher and SpyTag interaction claim 1 , and wherein i-ii form a virus-like particle displaying said antigen.3. The vaccine according claim 1 , wherein the virus capsid protein comprises an AP205 capsid protein.4. The vaccine according to claim 1 , wherein the virus capsid protein comprises an AP205 capsid protein and wherein the first peptide tag comprises one or more SpyCatcher claim 1 , and wherein the SpyCatcher is fused to the N-terminal end of the AP205 capsid protein.5. The vaccine according to claim 1 , wherein the virus capsid protein comprises or consists of an AP205 capsid protein and wherein the first peptide tag is one or more SpyTags.6. The vaccine according to claim 5 , wherein the SpyTag is fused to the N-terminal end or to the C-terminal end of the AP205 capsid protein.7. The vaccine according to claim 5 , ...

VIRUS-LIKE PARTICLE WITH EFFICIENT EPITOPE DISPLAY

The invention relates to a virus-like particle (VLP) based vaccine. The virus-like particle constitutes a non-naturally occurring, ordered and repetitive antigen array display scaffold which can obtain a strong and long-lasting immune response in a subject. The VLP-based vaccine may be used for the prophylaxis and/or treatment of a disease including, but is not limited to, cancer, cardiovascular, infectious, chronic, neurological diseases/disorders, asthma, and/or immune-inflammatory diseases/disorders. 1. An immunogenic virus-like particle having a surface , comprising:an AP205 capsid protein as set forth in SEQ ID NO: 58 or a biologically active variant thereof having at least 95% sequence identity to SEQ ID NO; 58, further comprising a first peptide tag, anda HER2 antigen as set forth in SEQ ID NO: 18 or a variant thereof having at least 90% sequence identity to SEQ ID NO: 18, further comprising a second peptide tag,wherein the HER2 antigen or variant thereof and the AP205 virus capsid protein or variant thereof are linked via an isopeptide bond between the first and second peptide tag, wherein the HER2 antigen is present on the surface of the immunogenic virus-like particle, andwherein the first peptide tag and the second peptide tag together represent a peptide tag pair.2. The immunogenic virus-like particle according to claim 1 , wherein the peptide tag pair is selected from the group consisting of i) a SpyTag and SpyCatcher pair claim 1 , and ii) a split-Spy0128 and Spy isopeptide pair.3. The immunogenic virus-like particle according to claim 2 , wherein the first peptide tag is a SpyTag and the second peptide tag is a SpyCatcher.4. The immunogenic virus-like particle according to claim 2 , wherein the first peptide tag a SpyCatcher and the second peptide tag is a SpyTag.5. The immunogenic virus-like particle according to claim 2 , wherein the first peptide tag is a split-Spy0128 and the second peptide tag is a Spy isopeptide.6. The immunogenic virus-like ...

Use of catalysts, method and apparatus for selective oxidation of ammonia in a gas containing hydrogen

The invention contributes to a cost effective way to solve the problem of trace ammonia removal from a hydrogen and nitrogen containing gas. The set of catalysts of the invention selectively oxidised ammonia in ppm concentration even in gas mixtures containing hydrogen gas in concentrations of three orders of magnitude higher than the concentration of ammonia.

VIRUS LIKE PARTICLE WITH EFFICIENT EPITOPE DISPLAY

The invention relates to a virus like particle (VLP) based vaccine. The virus-like particle constitutes a non-naturally occurring, ordered and repetitive antigen array display scaffold which can obtain a strong and long-lasting immune response in a subject. The VLP based vaccine may be used for the prophylaxis and/or treatment of a disease including, but is not limited to, cancer, cardiovascular, infectious, asthma, and/or allergy diseases/disorders. 1. A vaccine comprising:i. a papilloma virus (PV) L1 protein containing a biotin acceptor site, andii. a biotin molecule enzymatically conjugated to said biotin acceptor site, andiii. an antigen fused to a monovalent streptavidin,wherein the antigen and PV L1 protein are linked via the interaction between the monovalent streptavidin and the biotin molecule enzymatically conjugated to the biotin acceptor site of the PV L1 protein, and wherein i-iii form a virus like particle displaying said antigen.27.-. (canceled)8. The vaccine according to claim 1 , wherein the PV L1 protein is from a virus infecting mammals.9. The vaccine according to claim 1 , wherein the PV L1 protein is from the human PV genotype 16 and/or 118.10. The vaccine according to claim 1 , wherein the biotin acceptor site comprises amino acid sequence SEQ ID NO: 36.11. The vaccine according to claim 1 , wherein the biotin acceptor site is fused into a loop of the PV L1 protein claim 1 , the loop selected from the group consisting of: a DE-loop and an HI-loop of the PV L1 protein.12. The vaccine according to claim 1 , wherein the PV L1 protein containing the biotin acceptor site is a PV L1 protein derived from the human PV genotype 16 claim 1 , the PV 1 protein containing the biotin acceptor site having a PV L1 amino acid sequence wherein residues 134-137 (YAAN) are deleted compared to a wild-type PV L1 amino acid sequence claim 1 , and wherein the PV L1 protein contains the biotin acceptor site in a DE-loop at position 133/138 in the amino acid sequence of ...

PRODUCTION OF MACROCYCLIC DITERPENES IN RECOMBINANT HOSTS

The invention relates to recombinant microorganisms and methods for producing macrocyclic diterpene or oxidized macrocyclic diterpene. 1. A recombinant host comprising:(a) a gene encoding a cytochrome P450 (CYP) polypeptide capable of catalyzing hydroxylation of casbene at the 5-position and/or 6-position;(b) a gene encoding a CYP polypeptide capable of catalyzing oxidation of casbene at the 5-position to form a keto group;(c) a gene encoding a CYP polypeptide capable of catalyzing oxidation of casbene at the 9-position; and/or wherein at least one of the genes is a recombinant gene; and', 'wherein the host is capable of producing a macrocyclic diterpene or an oxidized macrocyclic diterpene., '(d) a gene encoding an alcohol dehydrogenase (ADH) polypeptide;'}2. The recombinant host of claim 1 , wherein the gene encoding the CYP polypeptide capable of catalyzing hydroxylation of casbene at the 5-position and/or 6-position comprises:(a) a gene encoding a CYP726A4 polypeptide;(b) a gene encoding a CYP726A27 polypeptide;(c) a gene encoding a CYP726A19 polypeptide; and/or(d) a gene encoding a CYP726A29 polypeptide.3. The recombinant host of any one of claim 1 , wherein the gene encoding the CYP polypeptide capable of catalyzing oxidation of casbene at the 5-position to form a keto group comprises:(a) a gene encoding a CYP726A19 polypeptide; and/or(b) a gene encoding a CYP726A29 polypeptide.4. The recombinant host of any one of claim 1 , wherein the gene encoding the CYP polypeptide capable of catalyzing oxidation of casbene at the 9-position comprises:(a) a gene encoding a CYP71D365 polypeptide; and/or(b) a gene encoding a CYP71D445 polypeptide.5. The recombinant host of any one of claim 1 , wherein the gene encoding the ADH polypeptide comprises a gene encoding an ADH1 polypeptide.6. The recombinant host of any one of - claim 1 , wherein:(a) the CYP726A4 polypeptide comprises a polypeptide having 70% or greater identity to an amino acid sequence set forth in SEQ ID NO:6 ...

STEREO-SPECIFIC SYNTHESIS OF (13R)-MANOYL OXIDE

The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention. 1. A method of manufacturing (13R)-manoyl oxide , said method comprising the steps of:(i) providing geranylgeranyl diphosphate (GGPP);(ii) contacting GGPP of step (i) with a first polypeptide having a sequence at least 75% identical to SEQ ID NO: 1 [CfTPS2] or SEQ ID NO: 2 [SsLPPS], thus obtaining labd-13-en-8,15-diol diphosphate (LPP); 'thus obtaining (13R)-manoyl-oxide.', '(iii) contacting the LPP of step (ii) with a second polypeptide having a sequence at least 75% identical to SEQ ID NO: 3 [CfTPS4], SEQ ID NO: 4 [CfTPS3] or SEQ ID NO: 5 [EpTPS8];'}2. The method according to any one of the preceding claims , wherein the (13R)-manoyl oxide obtained is enantiomerically pure.3. The method according to any one of the preceding claims , wherein the first polypeptide and the second polypeptide are present at a stoichiometry ratio between 2:1 and 1:2 , such as 1:1.4. The method according to any one of the preceding claims , further comprising a step of recovering the (13R)-manoyl oxide.5. The method according to any one of the preceding claims , where the method is performed in vivo.6. The method according to the preceding claims , wherein the first and second polypeptides are heterologously expressed in a host organism selected from the group comprising bacteria , yeast , fungi , plants , insects and mammals.7Escherichia coli, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Nicotiana benthamianaPhyscomitrella patens.. The method according to any one of the preceding claims , wherein the host organism is selected from ...

VIRUS-LIKE PARTICLE WITH EFFICIENT EPITOPE DISPLAY

The invention relates to a virus-like particle (VLP) based vaccine. The virus-like particle constitutes a non-naturally occurring, ordered and repetitive antigen array display scaffold which can obtain a strong and long-lasting immune response in a subject. The VLP-based vaccine may be used for the prophylaxis and/or treatment of a disease including, but is not limited to, cancer, cardiovascular, infectious, chronic, neurological diseases/disorders, asthma, and/or immune-inflammatory diseases/disorders. 1. A vaccine for use in the prophylaxis and/or treatment of a disease wherein the vaccine comprises:i. a virus capsid protein comprising a first peptide tag, andii. an antigen fused to a second peptide tag,wherein the antigen and virus capsid protein are linked via an isopeptide bond between the first and second peptide tag, and wherein i-ii form a virus-like particle displaying said antigen.2. The vaccine according to claim 1 , wherein the first peptide tag comprises a Spytag claim 1 , and wherein the second peptide tag comprises a SpyCatcher claim 1 , wherein the antigen and virus capsid protein are linked via the interaction between the SpyCatcher and SpyTag interaction claim 1 , and wherein i-ii form a virus-like particle displaying said antigen.34.-. (canceled)5. The vaccine according claim 1 , wherein the virus capsid protein comprises an AP205 capsid protein.6. The vaccine according to claim 1 , wherein the virus capsid protein comprises an AP205 capsid protein and wherein the first peptide tag comprises one or more SpyCatcher claim 1 , and wherein the SpyCatcher is fused to the N-terminal end or to the C-terminal end of the AP205 capsid protein.7. (canceled)8. The vaccine according to claim 1 , wherein the virus capsid protein comprises or consists of an AP205 capsid protein and wherein the first peptide tag is one or more SpyTags.9. The vaccine according to claim 8 , wherein the SpyTag is fused to the N-terminal end or to the C-terminal end of the AP205 ...

Compositions and methods for modulating connexin hemichannels

Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.

Process for removal of so2 from off-gases by reaction with h202

Method for lowering large structures through deep water for laying on the bottom.

Open sleeve in paper for the storage of disks etc.

A piece of paper with punchings, fold lines and flaps can be folded into a flat, open pocket without the need for other aids. The pocket has separated storage spaces and, thereby, minimises the risk of scratching on the surface of the disks where several disks are being stored together.All in accordance with the direction of fold on the paper, the pocket's outer side can incorporate two different graphic and text imprints. Given that the pocket can be separated and reassembled, imprints containing, for ex., user directions, contents summary and the like on the inside are another useful factor.<IMAGE>

Virus-like particle with efficient epitope presentation

Una vacuna para uso en la profilaxis y/o tratamiento de una enfermedad donde la vacuna comprende: i. una proteína L1 del papilomavirus (PV) que contiene un sitio aceptor de biotina, y ii. una molécula de biotina conjugada enzimáticamente a dicho sitio aceptor de biotina, y iii. un antígeno fusionado con una estreptavidina monovalente, donde la proteína PV L1 que contiene el sitio aceptor de biotina comprende una secuencia de aminoácidos seleccionada de entre el grupo que consiste en SEQ ID NO: 3 [bucle DE, genotipo 16 de HPV] y SEQ ID NO: 2 [bucle HI, genotipo 16 de HPV], donde el antígeno y la proteína PV L1 están unidos mediante la interacción entre la estreptavidina monovalente y la molécula de biotina conjugada enzimáticamente al sitio aceptor de biotina de la proteína PV L1, y donde i - iii forman una partícula similar a un virus que muestra dicho antígeno y donde el sitio aceptor de biotina comprende la secuencia de aminoácidos SEQ ID NO: 36.

T cell epitopes useful in a hepatitis c virus vaccine and as diagnostic tools and methods for identifying same

In a first aspect the present invention consists of T cell epitopes in the Hepatitis C virus genome. More specifically there is provided 429 linear peptide epitopes from the Hepatitis C Virus genome. In a second aspect the invention also consists of variants of these sequences. In a third aspect this invention consists of a method to predict these sequences from genome data and to validate the predictions experimentally. Ina fourth aspect the present invention provides compositions including these epitopes for use in a vaccine and to induce a T cell response in a subject, or as a diagnostic tool. Figure 2 shows a plot of the measured versus the predicted binding affinity score for four different prediction methods (1) Rammensee matrix method, (b) Hidden Markov model trained on sequences in the Rammensee dataset, (c) Neural network trained with sparse sequence encoding, and (d) The Comb-II neural network method.

Casting of concrete components

Process for removal of so2 from off-gases by reaction with h2o2

A process for removal of SO2 in off-gases having a temperature of 30-150~C and containing 0.001-1 vol% SO2 in which the SO2 is oxidised to H2 SO4 by spraying an aqueous solution of H2O2 into the off-gas upstream of an aerosol filter removing the produced sulphuric acid from the off-gas.

Method and systems for video collection and analysis thereof

A computer implemented method of performing video surveillance on a computer system, wherein the computer system comprises a video and a display with a graphical user interface, the graphical user interface including a source window to view play back of the video, the surveillance method comprising: determining an area of interest of a frame of the video based upon a selection of the area of interest within the source window, and generating a plurality of windows within the graphical user interface, each of the windows displaying the area of interest of the frame of the video at a point in time, wherein the graphical user interface includes controls to manipulate the playback of the video from a point in time relative to each displayed portion.

DEVICE FOR THEFT PROPERTY

Novel antiarrhythmic peptides

The present invention relates to a compound having the general formula (I) where the dashed line indicates that formula (I) is optionally cyclic, and the bonds shown represent covalent bonds; and wherein A represents a chemical moiety having an amino group (radical) and a carboxy group that forms part of the peptide bond connecting A to X and B; B represents a chemical moiety having an amino group (radical) and a carboxy group that forms part of the peptide bond connecting B to A and Y; X represents a peptide sequence of from 1 to 3 amino acid residues which independently may be an L or D form when Y represents a C-terminal peptide sequence of from 2 to 5 amino acid residues which may independently be L- or D-forms; or X represents an N-terminal modification of the group A-B when Y represents a C-terminal peptide sequence of from 2 to 5 amino acid residues which may independently be L- or D-forms; or X represents a peptide sequence of from 2 to 5 amino acid residues which may independently be L- or D-forms when Y represents a C-terminal peptide sequence of from 1 to 3 amino acid residues which independently may be an L or D form; and when formula (I) represents a linear peptide X is optionally chemically modified at its N-terminal, and L is an optional linking group comprising from 0 to 8 backbone atoms; and a mirror image or a retro analogue of formula (I), or a derivative of formula (I) which is a pharmaceutically acceptable salt, and alkyl, aryl or aralkyl ester, an amide, a mono or disubstituted amide where the substituent is an alkyl, an aryl or an aralkyl, a hydrazide, or an alcohol.

Platform built of uniform elements and mounted above the surface in deep water.

Polypeptides with diterpene synthase activity

The present invention relates to polypeptides with diterpene synthase activity. The invention further relates to polynucleotides encoding such polypeptides. Also provided are vectors for expression of the polypeptides and host cells expressing the polypeptides.

Flexible pipe and a method of producing a flexible pipe

The invention relates to a flexible pipe comprising an axis and a tubular innermost sealing sheath surrounding said axis, said innermost sealing sheath being surrounded by at least one outer armoring layer. The innermost sealing sheath has an inner side which is the side of the innermost sealing sheath comprising said axis. On the inner side of said innermost sealing sheath the flexible pipe comprises at least one carcass comprising a plurality of annular armoring members.

Submerged structure packing

Catalysts for selective oxidation of ammonia in a gas containing hydrogen

The invention contributes to a cost effective way to solve the problem of trace ammonia removal from a hydrogen and nitrogen containing gas. The set of catalysts of the invention selectively oxidised ammonia in ppm concentration even in gas mixtures containing hydrogen gas in concentrations of three orders of magnitude higher than the concentration of ammonia.

Targeting of chondroitin sulfate glycans

The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA).

Biosynthetic engineering of glucosinolates

The invention provides methods and materials, such as newly characterized genes, and novel processes, for converting a host from a phenotype whereby the host is unable to carry out glucosinolate (GSL) biosynthesis or chain elongation from an amino acid GSL-precursor to a phenotype whereby the host carries out said biosynthesis or elongation.

Method of connecting an accessory to a hearing aid and the combination of an adapter and an accessory

A combination unit for attachment to a hearing aid comprises an adapter and an accessory, having mating guideways, respective assembly pressure faces adjacent the guideways and respective disassembly pressure faces, also adjacent the guideways. The adapter comprises a shoe, i.e. a sleeve-like structure, adapted to partially enclose the lower portion of the hearing aid. The accessory may comprise a miniature FM receiver. The receiver housing exterior is tailored to match the adapter exterior in order that the respective walls are flush when the parts are assembled. The combination unit of the adapter and the accessory is easily assembled and easily disassembled, and is very compact. The invention provides a combination unit, including the shoe and the accessory, as well as a method for attaching an accessory to a hearing aid.

Virus-like particle with efficient epitope display

The invention relates to a virus-like particle (VLP) based vaccine. The virus-like particle constitutes a non-naturally occurring, ordered and repetitive antigen array display scaffold which can obtain a strong and long-lasting immune response in a subject. The VLP-based vaccine may be used for the prophylaxis and/or treatment of a disease including, but is not limited to, cancer, cardiovascular, infectious, chronic, neurological diseases/disorders, asthma, and/or immune-inflammatory diseases/disorders.

NEW ANTIARRYTHMIC PEPTIDES

Catalysts for selective oxidation of ammonia in a gas containing hydrogen

The invention contributes to a cost effective way to solve the problem of trace ammonia removal from a hydrogen and nitrogen containing gas. The set of catalysts of the invention selectively oxidised ammonia in ppm concentration even in gas mixtures containing hydrogen gas in concentrations of three orders of magnitude higher than the concentration of ammonia.

A flexible pipe and a method of producing a flexible pipe

The invention relates to a flexible pipe comprising an axis and a tubular innermost sealing sheath (2) surrounding said axis, said innermost sealing sheath (2) being surrounded by at least one outer armoring layer (3, 4, 5). On the inner side of said innermost sealing sheath (2) the flexible pipe comprises at least one carcass (1) comprising a plurality of annular or coil shaped armoring members. The flexible pipe of the invention can be used for offshore use at high depth, in corrosive environments and/or subjected to high external an internal pressure and pressure variations. Further, the invention relates to a method of producing the flexible pipe.

METHOD FOR CONNECTING AN ACCESSORY PART TO A HEARING DEVICE AND COMBINING ADAPTER AND ACCESSORIES

peptides including novel antiarrhythmic peptides of linear or cyclic structure having improved stability in vitro and/or in vivo, to compositions comprising said peptides, and to uses of said peptides for the preparation of medicaments.

Described is the use of compounds that facilitate the intercellular communication for the preparation of medicaments for the treatment of a range of diseases characterised in impaired intercellular gap junctional communication. Further described is a method of treating diseases, such as bladder incontinence, disorders of alveolar tissue and bronchial tissue, impaired hearing due to diseases of the cochlea, endothelial lesions, diabetic retinopathy and diabetic neuropathy, ischemia of the central nervous system and spinal cord, dental tissue disorders including periodontal disease, kidney diseases such as impaired secretion from the juxtaglomerular apparatus leading to hypertension, and a method of preventing failures of bone marrow transplantation.

Computer predictions of molecules

The present invention relates to calculation of the structure and/or the structural, biological, chemical or physical features of chemical substances from their constituents, such as the features of proteins from their amino acid sequence. In a first aspect of the invention prediction is obtained by using a system comprising a plurality of prediction means, which method comprises using a plurality of different individual prediction means, such as at least (16), thereby providing an individual prediction of the set of features for each of the individual prediction means and predicting the set of features on the basis of combining the individual predictions. According to the invention the combining being performed in such a manner that the combined prediction is more accurate on a test set than substantially any of the predictions of the individual prediction means.

Method of molding concrete construction elements and means intended for its implementation

DISPLAY FORM OF FRISBEE TYPE CASTLE

New medical applications of intercellular communication facilitating compounds

Det beskrives nye peptider inkludert antiarrytmiske peptider som har forbedret stabilitet. Det beskrives ytterligere preparater som inkluderer slike peptider og fremgangsmåte for anvendelse av preparatene, spesielt som medikamenter.

Targeting of chondroitin sulfate glycans

Supporting cushion

The present invention relates to a supporting cushion for comforting support of body parts, said cushion having a supporting area comprising a friction area, wherein the friction area is adapted to provide a frictional engagement with a supporting body part, when the cushion is supporting another body part. The cushion is preferably provided with two cushion parts provided for making contact with two opposite sides of the supporting body part. The cushion is preferably made of two layers of web material welded together, the cushion being designed for being inflatable.

Compositions and methods for modulating connexin hemichannels

Disclosed are compositions and methods for modulating hemichannel function i n a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.

Method and device for filling underwater structures with sand

Virus like particle with efficient epitope display

Optical amplifier and method for preventing the emitting of an optical power exceeding a preset

A method and an apparatus for cleaning and sterilizing dental equipment

The present invention relates to a method of cleaning and sterilizing dental equipment (80), which is intended to be introduced into the oral cavity of a patient, and which has an external surface and an internal channel defined by an internal surface, said method comprising a first step wherein the internal surface is affected by steam at such a temperature that the internal surface is sterilized. The invention is novel by an additional step wherein the external surface is affected by a relatively concentrated jet of steam at such a temperature that the external surface is sterilized, while a mechanical treatment of the external surface is performed by a brush-like means. The invention also relates to an apparatus for performing the method.

Methods for producing diterpenes

The present invention discloses that by combining different di TPS enzymes of class I and class II different diterpenes may be produced including diterpenes not identified in nature. Surprisingly it is revealed that a di TPS enzyme of class I of one species may be combined with a di TPS enzyme of class II from a different species, resulting in a high diversity of diterpenes, which can be produced.

Process for removal of so2 from off-gases by reaction with h2o2

A process for removal of SO 2 in off-gases having a temperature of 30-150° C. and containing 0.001-1 vol % SO 2 in which the SO 2 is oxidised to H 2 SO 4 by spraying an aqueous solution of H 2 O 2 into the off-gas upstream of an aerosol filter removing the produced sulphuric acid from the off-gas.

Connecting entities with general functionality in aspect patterns

A task oriented user interface increases ease of use of the system because the user is guided through the system. The tasks resemble how the user thinks he/she should do the job. This aids and assists the user in doing the job.

Method and apparatus for timing and event processing in wireless systems

A digital baseband processor is provided for concurrent operation with different wireless systems. The digital baseband processor includes a digital signal processor for executing digital signal processor instructions, a microcontroller for executing microcontroller instructions, and a timing and event processor controlled by the digital signal processor and the microcontroller for executing timing-sensitive instructions. The timing and event processor includes a plurality of instruction sequencers for executing timing-sensitive instruction threads and a time base generator for generating timing signals for initiating execution of the instruction threads on each of the plurality of instruction sequencers.

A set of flanges and a method of providing the set of flanges

A set of flanges, an installation comprising the set of flange and a method for providing the installation are disclosed. The set of flanges includes a first annular flange with a first front side and a second annular flange with a second front side. Each flange includes a plurality of through holes for mounting the flanges with the first side facing the second side. The first and the second sides are shaped such that the annular toe surface section of the first front side is adapted to provide an annular toe contact region with the annular toe surface section of the second front side and the annular heel surface section of the first front surface is adapted to provide annular heel contact region with the annular heel surface section of the second front side whereby an intermediate annular gap is provided between the annular toe contact region and the annular heel contact region.

Fabric containing unidirectional reinforcement fibre

A fabric and a method for making the same. The fabric includes a layer of unidirectionally oriented carbon fibre filaments sandwiched between a first layer of glass fibre rovings and a second layer of glass fibre rovings. The first layer of glass fibre rovings and the second layer of glass fibre rovings are linked by a connecting material.

Verfahren zum entfernen von so2 aus abgasen durch reaktion mith2o2

Neue antiarrythmische peptide

Apparatus and its use for selective oxidation of ammonia in a gas containing hydrogen

Targeting of chondroitin sulfate glycans

The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA).

Hidtil ukendte antiarrytmiske peptider

Verfahren zum anschluss eines zubehörteils an ein hörgerät und kombination aus adapter und zubehörteil

Nucleic acid vaccines

The present invention relates to modular nanoparticle-based compositions based on nucleic acids, such as DNA and RNA, which are particularly useful in prophylaxis and/or treatment of diseases and disorders.

Vacunas de acido nucleico.

La presente invención se refiere a composiciones modulares basadas en nanopartícula, basadas en ácidos nucleicos, tales como ADN y ARN, las cuales son particularmente útiles en la profilaxis y/o tratamiento de enfermedades y trastornos.

Medical visualisation device with programmable buttons

Disclosed is a monitor device operable to receive image data from one or more medical visualization devices and a medical visualization system comprising a monitor device. The monitor device comprising: a housing, and a processing unit adapted to receive the image data from the medical visualization device and cause a display to display a live representation of the image data. The monitor device displays with the display a graphical user interface and displays, within a first portion of the graphical user interface, a representation of a medical visualization device comprising one or more programmable buttons including a first programmable button. The monitor device is adapted to detect a first user input corresponding to selection of the first programmable button, and in response to detecting the first user input the monitor device displays, within a second portion of the graphical user interface, a first button setup menu for selecting one or more actions to be associated with one or more activations of the first programmable button.

Styring af adgang til et sted

Et apparat til at kontrollere adgangen til et sted, der er sikret af en l hvori apparatet omfatter en mobilenhed og en l til kontrol af l kanismen. Mobilenheden omfatter en lagringsenhed til lagring af en elektronisk nøgle, hvori den elektroniske nøgle indikerer en forudbestemt adgangsrettighed til stedet; en tr kommunikationsenhed til tr kommunikation med l enheden indrettet til automatisk at søge efter l p stedet, n mo bilenheden er i en forudbestemt afstand fra l hvor tr kom munikation mellem mobilenheden og l er etableret; og til automa tisk oprettelse af en forbindelse til l og automatisk overførelse af den elektroniske nøgle til l L omfatter: en tr kommunikationsenhed indrettet til tr kommunikation med mobilenheden og til at modtage en elektronisk nøgle fra mobilenheden; kontrolmidler indrettet til at verificere den modtagne elektroniske nøgle og at iværksætte betjening af l kanismen afhængig af resultatet af verifikationen af den elektroniske nøgle.

Method of assembly of a water electrolysis stack, bipolar plates adapted for use in an electrolyser stack and use of bipolar plates.

Bipolar plates (1) adapted for use in an electrolyser cell stack (4) and wherein each plate comprises a plate midplane (2) whereby the plate (1) comprises spaced apart uniform bumps (7) extending in opposed directions from the midplane (2). All bumps (7) are arranged 5 along concentric circles (8) in the midplane (2) with bumps (7) alternatingly protruding in opposite directions relative to the midplane (2) along each concentric circle (8) and an even number of bumps (7) are provided in each circumferential circle (8), apart from an innermost circle (9) which comprises a single bump (7).

Szövedék, szintetikus üvegszerű szálakból

A részecskékből álló adalékanyagőt tartalmazó MMVF-szövedékkészítésére szőlgáló eljárás sőrán kialakítanak egy szálfelhőtüvegszerű őlvadékból való szálképzéssel, legalább egy centrifűgálisszélképző rőtőr alkalmazásával. Ezt a szálfelhőt a rőtőr vagy rőtőrőkmellől érkező levegőárammal egy átjárható szállítószalaghőzszállítják, majd a részecskékből álló adalékanyagőt bejűttatják aszálfelhőbe. Végül a szálakat és az adalékőt szövedék főrmájábanösszegyűjtik a szállítószalagőn. A részecskékből álló adalékanyagőt aszálfelhő haladási irányával szemben fúvatják be a szálfelhőbe. ŕ

Compounds useful in the diagnosis and treatment of malaria

The present invention relates to nucleic acid molecules related to the PFD1235w/MAL7P1.1, PF11&lowbar;0008, and PF13&lowbar;0003 gene familles as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to endotheilial cells, which is characteristic for the pathogenesis of severe malaria (SM). Accordingly, the invention provides pharmaceutical compositions and vaccines hereunder nucleotide-based vaccines comprising compounds that are related to VAR4, VAR5, and/or VAR6 polypeptides and PFD1235w/MAL7P1.1 PF11&lowbar;0008, and/or PF13&lowbar;0003 nucleic acid molecules. The invention further relates to the use of these compounds as medicaments and for the manufacture of compositions, such as immunogenic compositions. In addition, the invention relates to methods of treatment and prevention of sever malaria wherein these methods are based on the nucleic acid molecules and polypeptides of the invention. As these compounds can also be used as biotechnological tools the invention provides in vitro diagnostic methods and kits comprising reagents and IgGs/antibodies designated to the use in such methods. The invention also relates to methods of identifying agents capable of modulating the VAR4, VAR5, and/or VAR6 dependent adhesion to endothelial cells and agent capable of interacting with VAR4, VAR5, and/or VAR6. Finally, a method for identifying polypeptides, which will induce a specific IgG/antibody response upon administration to a subject is provided by the invention.

Fremgangsmåde og apparat til rengøring og sterlisering af dentaludstyr

A method and an apparatus for cleaning and sterilizing dental equipment

Method of assembly of a water electrolysis stack, bipolar plates adapted for use in an electrolyser stack and use of bipolar plates.

Bipolar plates (1) adapted for use in an electrolyser cell stack (4) and wherein each plate comprises a plate midplane (2) whereby the plate (1) comprises spaced apart uniform bumps (7) extending in opposed directions from the midplane (2). All bumps (7) are arranged 5 along concentric circles (8) in the midplane (2) with bumps (7) alternatingly protruding in opposite directions relative to the midplane (2) along each concentric circle (8) and an even number of bumps (7) are provided in each circumferential circle (8), apart from an innermost circle (9) which comprises a single bump (7).

Video laryngoscope

Disclosed is a laryngoscope assembly (4) and parts thereof. The laryngoscope assembly comprises a blade unit (100) extending from a proximal end (102) to a distal end (106), the blade unit having a distal part extending to the distal end and comprising a first surface (108), wherein the distal part is adapted to be inserted into a patient's oral cavity with the first surface facing the patient's tongue. The laryngoscope assembly further comprises a control unit (200) comprising a body portion having a first body portion (202A) and a second body portion (202B), the first body portion being couplable to the blade unit. The control unit and the blade unit, when being coupled, collectively form a laryngoscope. The control unit being adapted to receive image data from an image sensor (402) as the image data is being generated by the image sensor, wherein, at least when the control unit is coupled to the blade unit, the image data is indicative of a view from the distal part of the blade unit in a direction at least partly towards the distal end.

Medical visualisation system

A monitor device operable to receive image data from a medical visualization device and a medical visualization system comprising a monitor device are disclosed. The monitor device comprising: a housing, and a processing unit adapted to receive the image data from the medical visualization device and cause a display to display a graphical user interface. The monitor device: displays a live representation of the image data within a first portion of the graphical user interface, and displays a stopwatch button within a second portion of the graphical user interface.

Interzelluläre kommunikation erleichternden verbindungen und deren medizinischen verwendungen

Optischer verstärker und verfahren zur verhinderung von emission daraus enstandener optischer leistung die eine vorbeschriebene sicherheitsbegrenzung überschreitet

Optischer verstärker und verfahren zur verhinderung von emission daraus enstandener optischer leistung die eine vorbeschriebene sicherheitsbegrenzung überschreitet

An optical amplifier and a method of preventing emission therefrom of optical power exceeding a prescribed safety limit

Dichtung zum Abdichten der Fuge zwischen zwei Bauteilen, die unter Wasser abgesenkt werden

Set of flanges; an installation comprising a set of flanges and a method of providing the installation

A set of flanges, an installation including the set of flange and a method for providing the installation are disclosed. The set of flanges includes a first annular flange with a first front side and a second annular flange with a second front side. Each flange includes a plurality of through holes for mounting the flanges with the first side facing the second side. The first and the second sides are shaped such that the annular toe surface section of the first front side is adapted to provide an annular toe contact region with the annular toe surface section of the second front side and the annular heel surface section of the first front surface is adapted to provide annular heel contact region with the annular heel surface section of the second front side whereby an intermediate annular gap is provided between the annular toe contact region and the annular heel contact region.

Combined module and adapter for attachment to a hearing aid

Nucleic acid vaccines

The present invention relates to modular nanoparticle-based compositions based on nucleic acids, such as DNA and RNA, which are particularly useful in prophylaxis and/or treatment of diseases and disorders.

Nucleic acid vaccines

The present invention relates to modular nanoparticle-based compositions based on nucleic acids, such as DNA and RNA, which are particularly useful in prophylaxis and/or treatment of diseases and disorders.

Tela que contiene fibra de refuerzo no direccional.

Una tela y un método para hacer la misma. El tejido incluye una capa de filamentos de fibra de carbono orientados unidireccionalmente intercalados entre una primera capa de mechas de fibra de vidrio y una segunda capa de mechas de fibra de vidrio. La primera capa de mechas de fibra de vidrio y la segunda capa de mechas de fibra de vidrio están unidas por un material de conexión.

Fabric containing unidirectional reinforcement fibre

A fabric and a method for making the same. The fabric includes a layer of unidirectionally oriented carbon fibre filaments sandwiched between a first layer of glass fibre rovings and a second layer of glass fibre rovings. The first layer of glass fibre rovings and the second layer of glass fibre rovings are linked by a connecting material.

Fabric containing unidirectional reinforcement fibre

A fabric and a method for making the same. The fabric includes a layer of unidirectionally oriented carbon fibre filaments sandwiched between a first layer of glass fibre rovings and a second layer of glass fibre rovings. The first layer of glass fibre rovings and the second layer of glass fibre rovings are linked by a connecting material.

Verfahren zur Herstellung einer Gruendung fuer Bauwerke in grossen Wassertiefen

Novel antiarrhythmic peptides

Pressemekanisme til graveskjold.

Video laryngoscope

Disclosed is a laryngoscope assembly (4) and parts thereof. The laryngoscope assembly comprises a blade unit (100) extending from a proximal end (102) to a distal end (104), the blade unit having a distal part (106) extending to the distal end and comprising a first surface (108), wherein the distal part is adapted to be inserted into a patient's oral cavity with the first surface facing the patient's tongue. The laryngoscope assembly further comprises a control unit (200) comprising a body portion (202) having a first body portion (202A) and a second body portion (202B), the first body portion being couplable to the blade unit. The control unit and the blade unit, when being coupled, collectively form a laryngoscope. The control unit being adapted to receive image data from an image sensor as the image data is being generated by the image sensor, wherein, at least when the control unit is coupled to the blade unit, the image data is indicative of a view from the distal part of the blade unit in a direction at least partly towards the distal end.

Method of assembly of a water electrolysis stack, bipolar plates configured for use in an electrolyser stack and use of bipolar plates

Bipolar plates (1) adapted for use in an electrolyser cell stack (4) and wherein each plate comprises a plate midplane (2) whereby the plate (1) comprises spaced apart uniform spacers (7) extending in opposed directions from the midplane (2). All spacers (7) are arranged along concentric circles (8) in the midplane (2) with spacers (7) alternatingly protruding in opposite directions relative to the midplane (2) along each concentric circle (8) and an even number of spacers (7) are provided in each circumferential circle (8), apart from an innermost circle (9) which comprises a single spacer (7).

Method of assembly of a water electrolysis stack, bipolar plates configured for use in an electrolyser stack and use of bipolar plates

Bipolar plates (1) adapted for use in an electrolyser cell stack (4) and wherein each plate comprises a plate midplane (2) whereby the plate (1) comprises spaced apart uniform spacers (7) extending in opposed directions from the midplane (2). All spacers (7) are arranged along concentric circles (8) in the midplane (2) with spacers (7) alternatingly protruding in opposite directions relative to the midplane (2) along each concentric circle (8) and an even number of spacers (7) are provided in each circumferential circle (8), apart from an innermost circle (9) which comprises a single spacer (7).

Video laryngoscope

Disclosed is a laryngoscope assembly (4) and parts thereof. The laryngoscope assembly comprises a blade unit (100) extending from a proximal end (102) to a distal end (104), the blade unit having a distal part (106) extending to the distal end and comprising a first surface (108), wherein the distal part is adapted to be inserted into a patient's oral cavity with the first surface facing the patient's tongue. The laryngoscope assembly further comprises a control unit (200) comprising a body portion (202) having a first body portion (202A)and a second body portion (202B), the first body portion being couplable to the blade unit. The control unit and the blade unit, when being coupled, collectively form a laryngoscope. The control unit being adapted to receive image data from an image sensor as the image data is being generated by the image sensor, wherein, at least when the control unit is coupled to the blade unit, the image data is indicative of a view from the distal part of the blade unit in a direction at least partly towards the distal end.

Video laryngoscope

A laryngoscope assembly including a blade having a distal part extending to the distal end and including a first surface, wherein the distal part is adapted to be inserted into a patient's oral cavity with the first surface facing the patient's tongue. The laryngoscope assembly further includes a control unit including a body portion having a first body portion and a second body portion, the first body portion being couplable to the blade. The control unit and the blade, when being coupled, collectively form a laryngoscope. The control unit being adapted to receive image data from an image sensor as the image data is being generated by the image sensor, wherein, at least when the control unit is coupled to the blade, the image data is indicative of a view from the distal part of the blade in a direction at least partly towards the distal end.

ビデオ喉頭鏡

【課題】喉頭鏡アセンブリおよびその部品が開示される。【解決手段】喉頭鏡アセンブリ４は、近位端から遠位端まで延在するブレードユニット１００を備え、ブレードユニットは、遠位端まで延在し、第１の面を備える遠位部分を有し、遠位部分の第１の面が患者の舌に面して患者の口腔内に挿入されるように構成され、喉頭鏡アセンブリ４は、第１の本体部および第２の本体部を有する本体部を備える制御ユニット２００をさらに備え、第１の本体部はブレードユニットに結合可能である。制御ユニットとブレードユニットとが結合され、喉頭鏡を形成する。制御ユニットは、画像データが画像センサによって生成されている間に画像データを画像センサから受信するように構成されており、少なくとも制御ユニットがブレードユニットに結合されているとき、画像データは、少なくとも部分的に遠位端に向かう方向におけるブレードユニットの遠位部分からのビューを示す。【選択図】図１Ａ

Aparato y su uso para la oxidación selectiva de amoníaco en un gas que contiene hidrógeno

La invención contribuye a una forma rentable de resolver el problema de la eliminación de trazas de amoníaco de un gas que contiene hidrógeno y nitrógeno. El conjunto de catalizadores de la invención oxidó selectivamente amoníaco en una concentración de ppm incluso en mezclas de gases que contenían gas hidrógeno en concentraciones tres órdenes de magnitud superiores a la concentración de amoníaco. (Traducción automática con Google Translate, sin valor legal)

Kuverteringsapparat

Vandsko til heste og andre hov- og klovbærende dyr