Methods of modulation of the immune system

Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signalling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.

Ephrin and eph receptor mediated immune modulation

Methods and compositions for immune modulation are described. The methods involve modulating an ephrin or Eph receptor which consequently modulates an immune response, in particular a T cell response, modulates immune adhesion cell, modulates chemotaxis and/or migration and modulates apoptosis. The method is useful in treating a variety of conditions, including autoimmune disease, allergy, graft versus host disease, transplant rejection and cancer.

Novel compounds for modulating cell proliferation

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of Formula (1).

Novel compounds for modulating cell proliferation

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I: ...

Methods of modulation of the immune system

Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signalling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.

Compounds for modulating cell proliferation

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.

Methods of modulation of the immune system

Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signaling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.

Compounds for modulating cell proliferation

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I: ...

Ephrin and EPH receptor mediated immune modulation

Methods and compositions for immune modulation are described. The methods involve modulating an ephrin or Eph receptor which consequently modulates an immune response, in particular a T cell response, modulates immune adhesion cell, modulates chemotaxis and/or migration or modulates apoptosis. The method is useful in treating a variety of conditions, including autoimmune disease, allergy, graft versus host disease, transplant rejection and cancer.

Styryl acrylonitrile compounds and their use to promote myelopoiesis

The invention relates to the use of organic compounds, styryl acrylonitrile compounds to promote myelopoiesis. These compounds thefore may be used to treat a subject suffering from neutropenia and other conditions which would benefit from increased myelopoieses. Moreover, the compounds may be used to treat hematopoietic cells ex-vivo to promote myelopoiesis and therefore may be used advantageously in bone marrow or peripheral blood stem cell transplant.

Novel compounds for modulating cell proliferation

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I: ...

Compounds for modulating cell proliferation

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of Formula (I).

Novel Compounds for Modulating Cell Proliferation

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.

Novel compounds for modulating cell proliferation

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.

COMPOUNDS FOR THE MODULATION OF THE PROLIFERATION OF CELLS

Methods of modulation of the immune system

Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signalling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.

Verbindungen für die modulation der proliferation von zellen

Ενωσεις για ρυθμιση πολλαπλασιασμου κυτταρου

Αποκαλύπτονται νέες ενώσεις στρυρυλακρυλονιτριλίου οι οποίες είναι χρήσιμες στη θεραπεία μιας ποικιλίας πολλαπλασιαστικών διαταραχών κυττάρου, όπως καρκίνου. Οι ενώσεις είναι του Τύπου (I).

Methods of modulation of the immune system

Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signalling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.