Novel polysaccharide derivatives and their use for the preparation of chiral stationary phases suitable for separating isomers of chemical compounds.

DEVICE AND PROCESS OF WATER DISINFECTION BY IRRADIATION USING a RAYONNEMENTDONT the WAVELENGTH EAST OF 282NM.

L'invention a pou objet un dispositif de désinfection d'eau par irradiation, à l'aide d'au moins une lampe (2) rayonnant dans le domaine des ultraviolets,caractérisé en ce que ladite ou lesdites lampes (2) émettent un rayonnement d'une longueur d'onde de 282 nm. The invention relates to a device for disinfecting water by irradiation, using at least one lamp (2) radiating in the ultraviolet range, characterized in that said lamp or lamps (2) emit radiation with a wavelength of 282 nm.

DEVICE OF DEHUMIDIFICATION OF FOOD PRODUCTS SUCH HONEY

DEVICE OF DEHUMIDIFICATION OF FOOD PRODUCTS SUCH HONEY

L'invention concerne un dispositif de déshumidification (D) d'un liquide alimentaire (M) du type de celui comprenant une chambre (100) dans laquelle un flux d'air sec est créé, remarquable en ce que ladite chambre (100) comprend - un premier bac (200) dit supérieur, - un deuxième bac (300) dit inférieur disposé au-dessous du premier, - le flux d'air sec étant orienté entre les deux bacs, le premier bac (200) étant percé d'une pluralité d'orifices (220) traversés chacun par un fil ou tige (400) d'écoulement de sorte que le liquide alimentaire (M) placé dans le bac supérieur (200) s'écoule par gravité le long desdits fils (400) en étant soumis au flux d'air sec et se dépose dans le bac inférieur (300). Applications : déshumidification de liquides alimentaires tel du miel.

DEVICE AND PROCESS OF WATER DISINFECTION BY IRRADIATION USING a RADIATION OF WHICH the WAVELENGTH EAST OF 282NM.

BRAKE PAD FOR VEHICLE DISC BRAKE

A brake pad () includes a backing plate () of plastic material, a friction lining () overmolded on the backing plate () and a metal reinforcement plate () embedded in the backing plate (). The backing plate () has a solid peripheral structure () and an inner structure () made as a grid-like reticular structure having a plurality of cavities () evenly distributed on its surface and filled at least partially by the material of the friction lining (). At least part of the cavities () are made as through cavities, whereby the friction lining () forms columns () which extend into the through cavities () and improve the adhesion between the friction lining () and the backing plate (). The area of the through cavities () amounts at least to 4.5% of the area of the face of the friction lining () opposite to the one in contact with the backing plate (). 1. Brake pad comprising a backing plate of plastic material and a friction lining overmoulded on the backing plate , the backing plate comprising a solid peripheral structure and an inner structure having a plurality of cavities filled at least partially by the material of the friction lining , wherein at least part of the cavities are made as through cavities and wherein the through cavities occupy an area amounting at least to 4.5% of the area of a face of the friction lining opposite to a face in contact with the backing plate.2. Brake pad according to claim 1 , wherein the inner structure of the backing plate projects with respect to the peripheral structure claim 1 , in a direction perpendicular to a plane of the backing plate claim 1 , on the a side of the backing plate facing towards the friction lining.3. Brake pad according to claim 1 , wherein the cavities are evenly distributed on the a surface of the inner structure of the backing plate.4. Brake pad according to claim 3 , wherein the inner structure of the backing plate is made as a grid-like reticular structure comprising a first set of parallel and equally- ...

Process for preparing boronic acids and esters in the presence of magnesium metal

The present invention relates to the process for preparing a boronic acid or ester chemically, in which an aromatic compound is reacted with a boronating agent, in the presence of magnesium metal (Mg 0 ). The invention also relates to the boronic acids or esters that can be obtained by means of this process and to the use thereof for example as a synthesis intermediate, in the Suzuki reaction, in the pharmaceutical or alternatively electronics field.

COILED TUBING SPIRAL VENTURI TOOL

A tool and method based on proven technologies, to remove sand and other types of solid particulate materials and fluids from wellbores and conduits, resulting from well-drilling, well-production or both, and consequently to reactivate well production. As time passes, solid aggregates are consolidated, plugging the wellbore, so they can be removed following two stages: disintegration in small particles and its further transport to surface. The tool, modular, composed of different subsystems, is connected to the end of concentric coil tubing, operates promoting the aggregates disintegration by using a spiral jet to impact these solids and suctioning the small particles and well fluids, simultaneously or later, by using jet pumps based on a set of several venturis. Changes between different operation modes are imposed by modifying surface pump pressure levels and the tool does not need to be removed from the wellbore between different stages, reducing the overall operation time. 1. An attachable device to a concentric coiled tubing for removal of solids in conduits using a pressurized power fluid comprising:a sealing connection assembly being mechanically and hydraulically coupled to the concentric coiled tubing, connecting the device with the hydraulic and mechanic coiled tubing equipment out of the conduit;a hydraulic control subsystem comprising at least one power fluid contention element and at least one control valve assembly, the power fluid contention element being located at the entrance conduct of the power fluid into the device, the control valve assembly being at least one pressure biased multi position valve which selectively directs the pressurized power fluid flow into at least one internal fluid conducts depending on the pressure level of the power fluid, having at least one moveable element, at least one fixed element and at least one deformable spring;a suction head subsystem comprising at least one jet pump assembly, the jet pump assembly comprising ...

Desktop and mobile graphical user interface unification

Disclosed herein are system, method, and computer program product embodiments for unifying graphical user interface (GUI) displays across different device types. In an embodiment, a unification system may convert various GUI view appearing on, for example, a desktop device into a GUI view on a mobile device. Both devices may be accessing the same application and/or may use a cloud computing platform to access the application. The unification system may aid in reproducing GUI modifications performed on one user device onto other user devices. In this manner, the unification system may maintain a consistent look-and-feel for a user across different computing device type.

Graphical user interface management for different applications

Disclosed herein are system, method, and computer program product embodiments for unifying graphical user interface (GUI) displays across different device types. In an embodiment, a unification system may convert various GUI view appearing on, for example, a desktop device into a GUI view on a mobile device. Both devices may be accessing the same application and/or may use a cloud computing platform to access the application. The unification system may aid in reproducing GUI modifications performed on one user device onto other user devices. In this manner, the unification system may maintain a consistent look-and-feel for a user across different computing device type.

Offline Briefcase Synchronization

Disclosed herein are system, method, and computer program product embodiments for synchronizing an offline briefcase. An embodiment operates by defining an offline briefcase for a user group that is accessible offline at an application. The embodiment detects a change to a component of the offline briefcase. The embodiment sends a push notification to the application based on the detected change to the component. The embodiment receives a synchronization request from the application in response to the sent push notification. The embodiment then sends the changed component to the application based on the synchronization request. 1. A computer implemented method , comprising:defining, by at least one processor, an offline briefcase for a user group that is accessible offline at an application, wherein the offline briefcase comprises a component comprising record data and record metadata;detecting, by the at least one processor, a change to the component;sending, by the at least one processor, a push notification to the application based on the detected change to the component;receiving, by the at least one processor, a synchronization request from the application in response to the sent push notification; andsending, by the at least one processor, the changed component o the application based on the synchronization request.2. The method of claim 1 , wherein the record data represents an object claim 1 , and the record metadata defines how to display the object in the application.3. The method of claiml claim 1 ,further comprising:updating a synchronization status of the component for a user of the user group based on the detected change to the component.4. The method of claim 1 , further comprising:calculating a data size of the offline briefcase, andadding the data size to the push notification.5. The method of claim 1 , further comprising:determining a second component that is related to the component;adding the second component to the offline briefcase.6. The ...

INTELLIGENT PRIMING OF MOBILE DEVICE FOR FIELD SERVICE

Systems and methods are provided for intelligent priming of mobile devices for the representatives of an organization who make service calls or client visits. With intelligent priming, in some embodiments, the systems and methods analyze each potential service appointment or customer/client visit separately, identify a potential set of information most relevant for the appointment or visit, and download the same to the representatives' mobile device. This reduces the time required and amount of information for priming. In some embodiments, the intelligent priming systems and methods can also notify representatives of when they should prime or download, generate recommendations for the information to be primed or downloaded, and provide an indicator to the representative regarding the status of priming or download. 1. A method for intelligent priming of a mobile device , the method comprising:maintaining, by one or more processors, a default configuration specifying a set of default information for download on the mobile device;accessing, by the one or more processors, a database storing schedule information for a field service representative associated with the mobile device;identifying, by the one or more processors, a plurality of field service appointments in the schedule information; accessing, by the one or more processors, account information relating to the identified appointment;', 'processing, by the one or more processors, the account information to identify a subset of default information; and', 'downloading, by the one or more processors, the subset of default information to the mobile device., 'for each identified appointment2. The method of claim 1 , further comprising:accessing, by the one or more processors, one or more external databases storing information relating to a network accessibility at the identified appointment's time and location.3. The method of claim 2 , further comprising:determining, by the one or more processors, whether the ...

Pharmaceutical compounds

Compounds of Formulae Ia, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Apparatus with disc separator plates

Certain exemplary aspects of the present disclosure are directed towards an apparatus including a base deck, a plurality of storage mediums (e.g., discs) and a plurality of disc separator plates. The base deck includes a sidewall forming a cavity to house the storage medium, with slots in the sidewall in which each disc separator plate extends. The disc separator plates extend into spaces between peripheral ends of adjacent ones of the storage medium. This arrangement can be used to provide rigid coupling of the separator plates, which can mitigate issues relating to vibration or shock. Further, air flow can be mitigated in this regard, such as to reduce effects upon a magnetoresistive transducer that reads data from the storage mediums.

Tricyclic p13k inhibitor compounds and methods of use

Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use

Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Tricyclic PI3K inhibitor compounds and methods of use

Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

Tricyclic PI3K inhibitor compounds and methods of use

Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

Benzoxazepin pi3k inhibitor compounds and their use in the treatment of cancer

Jedinjenja Formule I:stereoizomeh, geometrijski izomeri, tautomeri i njihove farmaceutski prihvatljive soli, gde:Z1 je CR1 ili N; Z2 je CR2 ili N; Z3 je CR3 ili N; Z4 je CR4 ili N;B je pirazolil, ili imidazolil prsten spojen sa benzoksepinskim prstenom i odabran od sledećih struktura:R1, R2, R3 i R4 su nezavisno odabrani od: H, F, Cl, Br, J, -CN, -COR10, -CO2R10, -C(=O)N(R10)OR11, -C(=NR10)NR10R11, -C(=O)NR10R11, -NO2, -NR10R11, -NR12C(=O)R10, -NR12C(=O)OR11, -NR12C(=O)NR10R11, -NR12C(=O)(C1-C12alkilen)NR10R11, -NR12(C1-C12 alkilen)NR10R10, -NR12(C1-C12 alkilen)OR10, -NR12(C1-C12 alkilen)C(=O)NR10R11, -OR10, -S(O)2R10, -C(=O)NR10(C1-C12alkilen)NR10R11, -C(=O)NR10(C1-C12 alkilen)NR10C(=O) OR11, -C(=O)NR10(C1-C12alkilen)NR10C(=O)R11, -C(=O)NR10(C1-C12 alkilen)R10, C1-C12 alkil, C2-C8 alkenil, C2-C8 alkinil, C3-C12 karbociklil, C2-C20 heterociklil, C6-C20 aril, C1-C20 heteroaril, -(C3-C12 karbociklil)-(C1-C12 alkil), -(C2-C20 heterociklil)-(C1-C12 alkil), -(C6-C20 aril)-(C1-C12 alkil), -(C1-C20 heteroaril)-(C1-C12 alkil), -(C1-C12alkilen)-(C3-C12 karbociklil), -(C1-C12 alkilen)-(C2-C20 heterociklil), -(C1-C12alkilen)-(C2-C20 heterociklil)-(C2-C20 heterociklil), -(C1-C12 alkilen)-(C2-C20 heterociklil)-(C3-C12 karbociklil), -(C1-C12 alkilen)-(C2-C20 heterociklil)-C(=O)-(C2-C20 heterociklil), -(C1-C12alkilen)-( C1- C20heteroaril), -(C1- C12alkilen)-(C2-C20heterociklil)-(C1-C12 alkil), -(C1-C12alkilen)-(C6-C20 aril)-(C1- C12 alkil), -(C1-C12 alkilen)-(C1-C20 heteroaril)-(C1-C12alkil), -( C1- C12alkilen)-C(=O)-(C2-C20 heterociklil), -(C1-C12 alkilen)C(=O)OR10, -(C1-C12 alkilen)-NR10R11, -(C1-C12alkilen)NR12 C(=O)R10, -( C1-C12 alkilen)OR10, -(C1-C12 alkilen)-NR10-(C1-C12 alkilen)-(C1-C20 hetero-aril), -(C1- C12alkilen)-NR10-( C1- C12 alkilen)-(C1- C20 heterociklil), -(C1-C12alkilen)-NR10-(C1-C12alkilen)-NHC(=O)-(C1-C20heteroaril), -(C1-C12alkilen)-(C2-C20heterociklil)-NR10R11 i -(C1- C12alkilen)-(C2-C20heterociklil)-(C1-C12alkil)-NR10R11,pri čemu su alkil, alkenil, alkinil, ...

Disclosure of a method of surface cross-linking highly neutralized superabsorbent polymer particles using Bronstedt acids

The present invention relates to a method of surface cross-linking superabsorbent polymer particles using UV irradiation. The method is carried out in a so-called drum reactor, which comprises a hollow drum and an irradiation source. The drum has a longitudinal axis and a cross-section. Radical former molecules are applied on the surface of superabsorbent polymer particles. These superabsorbent polymer particles are fed into the drum and are irradiated while they move within the drum, which is rotated around its longitudinal axis. The irradiation source is provided such that the radiation emitted by the irradiation source is able to reach superabsorbent polymer particles within said drum. The irradiation source for use in the method of the present invention is able to emit UV radiation of a wavelength between 201 nm and 400 nm.

Method of surface cross-linking superabsorbent polymer particles using vacuum ultraviolet radiation

The present invention relates to a method of surface cross-linking superabsorbent polymer particles using UV irradiation. The method is carried out in a so-called drum reactor, which comprises a hollow drum and an irradiation source. The drum has a longitudinal axis and a cross-section. Superabsorbent polymer particles are fed into the drum and are irradiated while they move within the drum, which is rotated around its longitudinal axis. The irradiation source is provided such that the radiation emitted by the irradiation source is able to reach superabsorbent polymer particles within said drum. The irradiation source for use in the method of the present invention is able to emit UV radiation of a wavelength between 100 nm and 200 nm.

Method of surface cross-linking superabsorbent polymer particles using vacuum ultraviolet radiation

The present invention relates to a method of surface cross-linking superabsorbent polymer particles using UV irradiation. The method is carried out in a so-called drum reactor, which comprises a hollow drum and an irradiation source. The drum has a longitudinal axis and a cross-section. Superabsorbent polymer particles are fed into the drum and are irradiated while they move within the drum, which is rotated around its longitudinal axis. The irradiation source is provided such that the radiation emitted by the irradiation source is able to reach superabsorbent polymer particles within said drum. The irradiation source for use in the method of the present invention is able to emit UV radiation of a wavelength between 100 nm and 200 nm.

Absorbent articles comprising surface cross-linked superabsorbent polymer particles made by a method using vacuum ultraviolet radiation

A method of surface cross-linking superabsorbent polymer particles using UV irradiation is provided. The method is carried out in a so-called drum reactor, which comprises a hollow drum and an irradiation source. The drum has a longitudinal axis and a cross-section. Superabsorbent polymer particles are fed into the drum and are irradiated while they move within the drum, which is rotated around its longitudinal axis. The irradiation source is provided such that the radiation emitted by the irradiation source is able to reach superabsorbent polymer particles within said drum. The irradiation source for use in the method is able to emit UV radiation of a wavelength between about 100 nm and about 200 nm.

Absorbent articles comprising surface cross-linked superabsorbent polymer particles made by a method using ultraviolet radiation

The present invention relates to absorbent articles comprising superabsorbent polymer (SAP) particles, the SAP particles being made by a method of surface cross-linking superabsorbent polymer particles using UV irradiation. The method is carried out in a so-called drum reactor, which comprises a hollow drum and an irradiation source. The drum has a longitudinal axis and a cross-section. Radical former molecules are applied on the surface of superabsorbent polymer particles. These superabsorbent polymer particles are fed into the drum and are irradiated while they move within the drum, which is rotated around its longitudinal axis. The irradiation source is provided such that the radiation emitted by the irradiation source is able to reach superabsorbent polymer particles within said drum. The irradiation source for use in the method of the present invention is able to emit UV radiation of a wavelength between 201 nm and 400 nm.

Method of surface cross-linking superabsorbent polymer particles using ultraviolet radiation

The present invention relates to a method of surface cross-linking superabsorbent polymer particles using UV irradiation. The method is carried out in a so-called drum reactor, which comprises a hollow drum and an irradiation source. The drum has a longitudinal axis and a cross-section. Radical former molecules are applied on the surface of superabsorbent polymer particles. These superabsorbent polymer particles are fed into the drum and are irradiated while they move within the drum, which is rotated around its longitudinal axis. The irradiation source is provided such that the radiation emitted by the irradiation source is able to reach superabsorbent polymer particles within said drum. The irradiation source for use in the method of the present invention is able to emit UV radiation of a wavelength between 201 nm and 400 nm.

PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE

SE REFIERE A UN COMPUESTO DE FORMULA Ic, Id, DONDE X ES O, S; R1 ES A; R2 ES H, F, Cl, ARIL C6-C20, ENTRE OTROS; R3 ES PIRIDILO, ISOXAZOLIL, PIRIMIDINIL, TETRAZOLIL, ENTRE OTROS; R4 Y R5 SON JUNTO AL ATOMO DE N ADYANCENTE PIRROLIDINA, MORFOLINA, DIAZEPAN, 2,5-DIAZABICICLO[2,2,1]-HEPTANO, ENTRE OTROS; R30 ES H, ALQUIL C1-C6; mor ES UN GRUPO MORFOLINO SUSTITUIDO CON UNO O MAS Cl, I, C(ALQUIL C1-C6), -C(=O)NR12(CR14R15)mNR10R11, ENTRE OTROS; R10, R11 Y R12 SON H, ALQUENIL C2-C8, CARBOCICLIL C3-C12, ARIL C6-C20, ENTRE OTROS; R14 Y R15 SON H, ALQUIL C1-C12 O -(CH2)n-ARIL; m ES 0-1. SON COMPUESTOS SELECCIONADOS: 1-(4-((2-(2-AMINOPIRIMIDIN-5-IL)-4-MORFOLINOTIENO[3,2-d]PIRIMIDIN-6-IL)METIL)PIPERAZIN-1-IL)-2-(METILSULFONIL)ETANONA; 2-AMINO-1-(4-((2-(2-AMINOPIRIMIDIN-5-IL)-4-MORFOLINOTIENO[3,2-d]PIRIMIDIN-6-IL)METIL)PIPERAZIN-1-IL)ETANONA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION, COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LA ACTIVIDAD CINASA, TAL COMO PI3K, UTIL EN EL TRATAMIENTO DE DESORDENES HIPERPROLIFERATIVOS COMO EL CANCER

Free-flowing powder fabric softening composition and process for its manufacture

Benzoxepin pi3k inhibitor compounds and methods of use

Benzoxepin compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z 1 is CR 1 or N; Z 2 is CR 2 or N; Z 3 is CR 3 or N; Z 4 is CR 4 or N; and where (i) X 1 is N and X 2 is S, (ii) X 1 is S and X 2 is N, (iii) X 1 is CR 7 and X 2 is S, (iv) X 1 is S and X 2 is CR 7 ; (v) X 1 is NR 8 and X 2 is N, (vi) X 1 is N and X 2 is NR 8 , (vii) X 1 is CR 7 and X 2 is O, (viii) X 1 is O and X 2 is CR 7 , (ix) X 1 is CR 7 and X 2 is C(R 7 ) 2 , (x) X 1 is C(R 7 ) 2 and X 2 is CR 7 ; (xi) X 1 is N and X 2 is O, or (xii) X 1 is O and X 2 is N, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of P13K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

NEW OPTICAL MATERIALS AND APPLICATIONS THEREOF

La présente invention concerne de nouveaux matériaux présentant des propriétés optiques surprenantes résultant de l'association de polymères avec un ou plusieurs colorants organiques. The present invention relates to novel materials having surprising optical properties resulting from the combination of polymers with one or more organic dyes.

Improvements to jet aircraft

POLYMERS CONTAINING REPEATING UNITS WITH SEVERAL METALLIC OR ORGANIC SULPHONATE PATTERNS, THEIR PREPARATION METHODS AND THEIR USES

POLYMERES CONTENANT DES UNITES DE REPETITION AVEC PLUSIEURS MOTIFS SULFONATES METALLIQUES OU ORGANIQUES, LEURS PROCEDES DE PREPARATION ET LEURS UTILISATIONS La présente invention concerne de nouveaux polymères contenant statistiquement plusieurs motifs sulfoniques ou sulfonates métalliques par unité de répétition, leurs procédés de préparation et leurs emplois comme antibactériens, fongicides, antiviraux et catalyseurs. POLYMERS CONTAINING REPEATING UNITS WITH SEVERAL METALLIC OR ORGANIC SULPHONATE UNITS, THEIR PREPARATION PROCESSES AND THEIR USES , fungicides, antivirals and catalysts.

NOVEL POLYMERS CONTAINING SULFONAMIDE LITHIUM OR SODIUM SALTS, PROCESSES FOR THEIR PREPARATION AND USES THEREOF AS ELECTROLYTES FOR BATTERIES

L'invention concerne de nouveaux polymères contenant des sulfonamides de lithium ou de sodium gréffés, leurs procédés de préparation et leurs utilisations comme éllectolytes dans des batteries. The invention relates to novel polymers containing lithium or sodium sulphonamides, processes for their preparation and their use as electolytes in batteries.

Table leg/trestle

The invention can be used either as a LEG or as a TRESTLE with complete adjustability for height and width. As a LEG it fastens to the table top and give great stability, especially on a door of a dwelling. It enables those who have little room to make up a large table for 10 people or 10 places in a few moments with the appearance of a conventional table. According to the invention, a door of a dwelling can be used as the table top, making it unnecessary to store a large table top. The TRESTLE/LEG avoids the problems of the conventional TRESTLE, namely shortage of space, discomfort for the person sitting opposite, and in addition its lack of stability. The TRESTLE/LEG turns upside down in either direction to become either a TABLE LEG or a conventional TRESTLE. It consists of two legs (4,4bis), the base of the legs consists of two extensions (9,9bis), and the top of the legs (4,4bis) ends in a T-shape illustrated at (2,2bis). The two cross members (3,3bis) enable the TRESTLE/LEG to be adjusted widthways, 2 being made up of two parts, one male and one female.

NOVEL POLYMERS CONTAINING AMMONIUM SULPHONATE FUNCTIONS, PROCESSES FOR THEIR PREPARATION AND THEIR USES AS CATALYSTS, ANTIBACTERIALS, FUNGICIDES

Corn combine harvester

NEW MATERIALS WITH OPTICAL EFFECTS AND THEIR APPLICATIONS

La présente invention concerne de nouveaux matériaux présentant des propriétés optiques surprenantes résultant de l'association de polymères avec un ou plusieurs colorants organiques. The present invention relates to new materials having surprising optical properties resulting from the association of polymers with one or more organic dyes.

NOVEL POLYMERS CONTAINING SULFONAMIDE LITHIUM OR SODIUM SALTS, PROCESSES FOR THEIR PREPARATION AND USES THEREOF AS ELECTROLYTES FOR BATTERIES

NOVEL POLYMERS CONTAINING BIS (SULFONYL) GRAFTED LITHIUM OR SODIUM SALTS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ELECTROLYTES FOR BATTERIES

PROCESS FOR THE PREPARATION OF ACIDS AND BORONIC ESTERS IN THE PRESENCE OF METAL MAGNESIUM

La présente invention se rapporte au pocédé de préparation d'un acide ou d'un ester boronique dans lequel on fait réagir avec un composé aromatique avec un agent de boration, en présence de magnésium métallique (Mg ). L'invention concerne également les acides ou esters boroniques susceptibles d'être obtenus par ce procédé et leur utilisation par exemple comme intermédiaire de synthèse, dans la réaction de Suzuki, dans le domaine pharmaceutique ou encore électronique. The present invention relates to the process for preparing a boronic acid or ester in which an aromatic compound is reacted with a borating agent in the presence of magnesium metal (Mg). The invention also relates to the boronic acids or esters obtainable by this process and their use, for example as synthesis intermediate, in the Suzuki reaction, in the pharmaceutical or electronic field.

Fused ring compounds

Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.

Serine protease inhibitors

Compounds having structure (A) are useful to inhibit serine protease enzymes , such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.</SD OAB>

Treatment to improve the germination of seeds and seeds treated in this way

Process for preparing boronic acids and esters in the presence of magnesium metal

The present invention relates to the process for preparing a boronic acid or ester chemically, in which an aromatic compound is reacted with a boronating agent, in the presence of magnesium metal (Mg 0 ). The invention also relates to the boronic acids or esters that can be obtained by means of this process and to the use thereof for example as a synthesis intermediate, in the Suzuki reaction, in the pharmaceutical or alternatively electronics field.

Brake pad for vehicle disc brake

A brake pad ( 10 ) includes a backing plate ( 12 ) of plastic material, a friction lining ( 14 ) overmolded on the backing plate ( 12 ) and a metal reinforcement plate ( 16 ) embedded in the backing plate ( 12 ). The backing plate ( 12 ) has a solid peripheral structure ( 18 ) and an inner structure ( 20 ) made as a grid-like reticular structure having a plurality of cavities ( 22 ) evenly distributed on its surface and filled at least partially by the material of the friction lining ( 14 ). At least part of the cavities ( 22 ) are made as through cavities, whereby the friction lining ( 14 ) forms columns ( 24 ) which extend into the through cavities ( 22 ) and improve the adhesion between the friction lining ( 14 ) and the backing plate ( 12 ). The area of the through cavities ( 22 ) amounts at least to 4.5% of the area of the face of the friction lining ( 14 ) opposite to the one in contact with the backing plate ( 12 ).

Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use

Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of P13K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Phosphoinositide 3-kinase inhibitor compounds and methods of use

Method for making transparent polythiourethane substrates in particular optical substrates

A method of fast curing polythiourethane transparent casted substrate, usabl e for making optical articles such as ophthalmic lenses, which comprises the steps of: 1) Providing a first componentA comprising a polythiourethane prepolymer having isocyanate or isothiocyanate end groups and a viscosity at 25 ~C ranging from 0.02 to 0.4 Pa.s; 2) Providing a second component B comprising a polythiourethane prepolymer having thiol (SH) end groups and a viscosity at 25 ~C ranging from 0.2 to 2.0 Pa.s; 3) Mixing together first an d second components A and B and filling a moulding cavity of a casting mould assembly with the resulting mixture ; 4) Curing said mixture to obtain a transparent solid substrate, said curing step comprising: a) a first step fo r polymerizing said mixture to obtain a gel within 1 to 10 minutes; and b) a second step of post-curing the gel to obtain the transparent solid substrate ; and 5) Recovering the transparent solid substrate from the mould.

Assembly for coaxial cables.

Device for eliminating leaf curl.

Process of preparing enriched enantiomers of glycerol carbonate and derivatives thereof for synthesis of β-blockers

Enriched enantiomers of glycerol Carbonate are produced under the influence of a hydrolytic enzyme, either by selective esterification of racemic glycerol carbonate or by selective hydrolysis of an ester of the racemate. The enriched enantiomeric product is readily converted to starting materials and intermediates useful in the synthesis of enantiomerically pure therapeutic agents, such as β-adrenergic blockers.

Device for automatic coupling of wagons

NOVEL POLYMERS CONTAINING BIS (SULFONYL) GRAFTED LITHIUM OR SODIUM SALTS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ELECTROLYTES FOR BATTERIES

L'invention concerne de nouveaux polymères contenant des bis (sulfonyl) imides de lithium ou de sodium gréffés, leurs procédés de préparation et leurs utilisations comme électrolytes dans des batteries. The invention relates to novel polymers containing lithium bis or sodium bis (sulfonyl) imides, processes for their preparation and their use as electrolytes in batteries.

Protection against environmental toxicity through manipulation of the processing of messenger rna precursors

This invention describes the identification of pre-messenger RNA processing as a novel target of environmental stress caused for example by lithium and sodium toxicity. Overexpression of different types of proteins (or protein fragments) from different organisms but all involved in pre-mRNA processing, protects yeast from salt stress, which indicates that any stimulation of this process, independently of its mechanism, may counteract the toxic effects of mineral salts. A similar phenotype of tolerance to NaCl and to LiCl has been observed by overexpression of these types of proteins in transgenic Arabidopsis plants, demonstrating the generality of this protective effect in eukaryotic cells and organisms.

Bisamidhæmmere the hedgehog-signalling

PROCESS TO PRODUCE A SOFTENING COMPOSITION OF FABRICS, IN PARTICULATES, DRY BY ASPERSION, OF FREE FLOW

Bisamide inhibitors of hedgehog signaling

High force low voltage piezoelectric micromirror actuator

A micromirror array comprises a substrate, a plurality of mirrors for reflecting incident light and, for each mirror of the plurality of mirrors, at least one multilayer piezoelectric actuator for displacing the mirror, wherein the at least one multilayer piezoelectric actuator is connected to the substrate, and wherein the at least one multilayer piezoelectric actuator comprises a plurality of piezoelectric layers of piezoelectric material interleaved with a plurality of electrode layers to form a stack of layers. Also disclosed is a method of forming such a micromirror array. The micromirror array may be used in a programmable illuminator. The programmable illuminator may be used in a lithographic apparatus and/or in an inspection and/or metrology apparatus.

Benzoxepin pi3k inhibitor compounds and methods of use

Benzoxepin compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z 1 is CR 1 or N; Z 2 is CR 2 or N; Z 3 is CR 3 or N; Z 4 is CR 4 or N; and where (i) X 1 is N and X 2 is S, (ii) X 1 is S and X 2 is N, (iii) X 1 is CR 7 and X 2 is S, (iv) X 1 is S and X 2 is CR 7 ; (v) X 1 is NR 8 and X 2 is N, (vi) X 1 is N and X 2 is NR 8 , (vii) X 1 is CR 7 and X 2 is O, (viii) X 1 is O and X 2 is CR 7 , (ix) X 1 is CR 7 and X 2 is C(R 7 ) 2 , (x) X 1 is C(R 7 ) 2 and X 2 is CR 7 ; (xi) X 1 is N and X 2 is O, or (xii) X 1 is O and X 2 is N, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

METHOD FOR OBTAINING A LIQUID FERTILIZER FROM PLANT BIOMASS

A presente invenção proporciona um método de obtenção de um fertilizante líquido a partir de biomassa vegetal, entendendo-se como biomassa vegetal aqueles restos vegetais, por exemplo de culturas agrícolas, obtidos uma vez tenha acabado seu ciclo de produção ou crescimento, permitindo tal método transformar esta biomassa sólida em uma solução fertilizante líquida que pode ser dosificada de forma simples, por exemplo por fertirrigação, revalorizando assim, por exemplo, rejeitos de culturas que, de outra maneira, seriam eliminados em incineradoras ou similares.

Polyfunctional hexasubstituted benzene derivatives

Polyfunctional hexasubstituted benzene derivatives wherein at least three of the substituents are saturated carbon chains having from 1 to 21 carbon atoms and functional groups containing hetero functionalities at the ends of the carbon chains and the remainder of the 6 substituents are either saturated carbon chains containing from 1 to 21 carbon atoms or saturated carbon chains containing from 1 to 21 carbon atoms having a functional group including a hetero functional group containing N, O, S, P, or Si at the end of the chains. These derivatives are made by reacting a disubstituted alkyne wherein one or both of the substituents are saturated carbon chains having 1 to 21 carbon atoms to which hetero functional groups are attached with a palladium catalyst and isolating the resulting hexasubstituted benzene derivative.

Tricyclic pi3k inhibitor compounds and methods of use

Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti- inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

Synthesis of a perfluoroalkylbromide by photochemical bromination of the corresponding iodide

The invention relates to the preparation of a perfluoroalkyl bromide RFBr by photochemical bromination of the corresponding iodide RFI in solution in an inert solvent. The bromination is initiated by homolytic cleavage of the C-I bond of the RFI compound, in the presence of bromine. For this, use is made of a specific radiation lamp, such as a lamp possessing an XeCl<*> or I2<*> excimer.

NOVEL POLYMERS CONTAINING AMMONIUM SULPHONATE FUNCTIONS, PROCESSES FOR THEIR PREPARATION AND THEIR USES AS CATALYSTS, ANTIBACTERIALS, FUNGICIDES

La présente invention concerne de nouveaux polymères contenant des fonctions sulfonates d'ammonium ou de phosphoniums supportés, leurs procédés de préparation et leurs utilisations dans différentes applications catalyseurs, antibactériens, antifongiques, antimicrobiens. The present invention relates to novel polymers containing supported ammonium or phosphonium sulfonate functional groups, processes for their preparation and their uses in various catalyst, antibacterial, antifungal, antimicrobial applications.

Method for protein-preserving purification of contaminated biological liquids

A method for protein-preserving purification and/or sterilization of contaminated biological liquids is de-scribed, in which the biological liquid is irradiated with UV radiation of 260 to 300 nm wavelength for a sufficient period of time.

Windshield wipers for vehicles

PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS

REFERIDA A UN DERIVADO DE PIRIMIDINA DE FORMULA (Ic) O (Id), DONDE X ES O O S; R1 ES H, F, -C(ALQUILO C1-C6)2NR10R11, ENTRE OTROS; R2 ES H, ARILO DE 6 A 20 MIEMBROS, ALQUILO C1-C6, ENTRE OTROS; R3 ES PIRIDILO, ISOXAZOLILO, IMIDAZOLILO, ENTRE OTROS; R10 Y R11 SON H, ALQUILO C1-C12, ALQUENILO C2-C8, ENTRE OTROS; mor ES UN GRUPO MORFOLINO OPCIONALMENTE SUSTITUIDO CON F, Br, -C(ALQUILO C1-C6)2NR10R11, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(2-(2-AMINOPIRIMIDI-5-NIL)-4-MORFOLINOTIENO[3,2-d]PIRIMIDI-6-NIL)N-METILSULFONILPIPERIDI-4-NOL, N-((2-(2-AMINOPIRIMIDI-5-NIL)-4-MORFOLINOTIENO[2,3-dPIRIMIDI-6-NIL)METIL)-N-METILBENZAMIDA, N-((2-(2-AMINOPIRIMIDI--5-NIL)-4-MORFOLINOTIENO[2,3-d]PIRIMIDI-6--NIL)METIL)-N-METILNICOTINAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE CINASAS LIPIDICAS, PARTICULARMENTE FOSFOINOSITIDA 3-CINASA (PI3) Y SON UTILES EN EL TRATAMIENTO DEL CANCER REFERRED TO A PYRIMIDINE DERIVATIVE OF FORMULA (Ic) O (Id), WHERE X IS O O S; R1 IS H, F, -C (C1-C6 ALKYL) 2NR10R11, AMONG OTHERS; R2 IS H, ARYL OF 6 TO 20 MEMBERS, C1-C6 ALKYL, AMONG OTHERS; R3 IS PYRIDYL, ISOXAZOLYL, IMIDAZOLYL, AMONG OTHERS; R10 AND R11 ARE H, C1-C12 ALKYL, C2-C8 ALKYL, AMONG OTHERS; mor IS A MORPHOLINE GROUP OPTIONALLY SUBSTITUTED WITH F, Br, -C (C1-C6 ALKYL) 2NR10R11, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: 4- (2- (2-AMINOPYRIMIDI-5-NIL) -4-MORPHOLINOTIENO [3,2-d] PIRIMIDI-6-NIL) N-METHYLSULFONYLPIPERIDI-4-NOL, N - ((2- ( 2-AMINOPYRIMIDI-5-NIL) -4-MORPHOLINOTIENO [2,3-dPYRIMIDI-6-NIL) METHYL) -N-METHYLBENZAMIDE, N - ((2- (2-AMINOPYRIMIDI-5-NIL) -4-MORPHOLINOTIENO [2,3-d] PYRIMIDI-6-NIL) METHYL) -N-METHYLNICOTINAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE MODULATORS OF LIPID KINASES, PARTICULARLY PHOSPHOINOSITIDE 3-KINASE (PI3) AND ARE USEFUL IN THE TREATMENT OF CANCER

Device for eliminating sheet curl

Improved method of extraction of humic substances from coal

La presente invención proporciona un procedimiento mejorado para la extracción por oxidación de sustancias húmicas a partir de carbón, incorporando el procedimiento una etapa de molturación por sonicación previa a la etapa de oxidación y donde la etapa de oxidación se lleva a cabo en presencia de un oxidante bajo irradiación con luz ultravioleta. The present invention provides an improved process for the extraction by oxidation of humic substances from coal, the process incorporating a grinding stage by sonication prior to the oxidation stage and where the oxidation stage is carried out in the presence of an oxidant under UV light irradiation.

Phosphoinositide 3-kinase inhibitor compounds and methods of use

Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them.

Se describen compuestos de las Fórmula Ia y Ib, (ver fórmula (Ia)) (ver fórmula (Ib)) e incluyendo estereoisómeros, isómeros geométricos, tautómeros, solvatos, metabolitos y sales farmacéuticamente aceptables de los mismos, que son útiles para inhibir cinasas lípidas incluyendo PI3K, y para tratar trastornos tales como cáncer mediado por cinasas lípidas. Se describen métodos para usar compuestos de la Fórmula Ia y Ib para diagnóstico in vitro, in situ, e in vivo, prevención o tratamiento de tales trastornos en células de mamíferos, o condiciones patológicas asociadas.

Prenatal and lactation supplements to enhance central nervous system development of offspring

Disclosed are prenatal and lactation supplements for pregnant women and lactating women, which include a combination of RRR-alpha-tocopherol, docosahexaenoic acid (DHA), trans-lutein, phospholipids, and at least one nuclear receptor activating ligand other than RRR-alpha-tocopherol, DHA, and trans-lutein. The supplements may enhance central nervous system development in a fetus or breast-feeding newborn infant.

Benzoxazepin pi3k inhibitor compounds and methods of use

The invention relates to benzoxazepin compounds of Formula (I) including stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring which compounds have anti-cancer activity, and more specifically, inhibit PI3 kinase activity.

Benzoxin combinations pi3k inhibitors and methods of use

L'INVENTION PORTE SUR DES COMPOSÉS DE BENZOXÉPINE DE FORMULE I, Y COMPRIS LES STÉRÉOISOMÈRES, ISOMÈRES GÉOMÉTRIQUES, TAUTOMÈRES, SOLVATES, MÉTABOLITES ET SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CEUX-CI, DANS LAQUELLE FORMULE : Z1 REPRÉSENTE CR1 OU N; Z2 REPRÉSENTE CR2 OU N; Z3 REPRÉSENTE CR3 OU N; Z4 REPRÉSENTE CR4 OU N; ET DANS LAQUELLE (I) X1 REPRÉSENTE N ET X2 REPRÉSENTE S, (II) X1 REPRÉSENTE S ET X2 REPRÉSENTE N, (III) X1 REPRÉSENTE CR7 ET X2 REPRÉSENTE S, (IV) X1 REPRÉSENTE S ET X2 REPRÉSENTE CR7; (V) X1 REPRÉSENTE NR8 ET X2 REPRÉSENTE N, (VI) X1 REPRÉSENTE N ET X2 REPRÉSENTE NR8, (VII) X1 REPRÉSENTE CR7 ET X2 REPRÉSENTE O, (VIII) X1 REPRÉSENTE O ET X2 REPRÉSENTE CR7, (IX) X1 REPRÉSENTE CR7 ET X2 REPRÉSENTE C(R7)2, (X) X1 REPRÉSENTE C(R7)2 ET X2 REPRÉSENTE CR7; (XI) X1 REPRÉSENTE N ET X2 REPRÉSENTE O OU (XII) X1 REPRÉSENTE O ET X2 REPRÉSENTE N, LESQUELS SONT UTILES POUR L'INHIBITION DE LIPIDE-KINASES, DONT LA P110-ALPHA ET D'AUTRES ISOFORMES DE PI3K, ET POUR LE TRAITEMENT DE TROUBLES TELS QU'UN CANCER À MÉDIATION PAR DES LIPIDE-KINASES. L'INVENTION PORTE ÉGALEMENT SUR DES PROCÉDÉS D'UTILISATION DE COMPOSÉS DE FORMULE I POUR LE DIAGNOSTIC IN VITRO, IN SITU ET IN VIVO, LA PRÉVENTION OU LE TRAITEMENT DE TELS TROUBLES DANS DES CELLULES DE MAMMIFÈRE, OU D'ÉTATS PATHOLOGIQUES ASSOCIÉS. The invention relates to benzoexperin compounds of Formula I, including the stereoisomers, geometrical isomers, TAUTOMERS, SOLVATES, METABOLITES, and PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, IN WHICH THE FORMULA: Z1 REPRESENTS CR1 OR N; Z2 REPRESENTS CR2 OR N; Z3 REPRESENTS CR3 OR N; Z4 REPRESENTS CR4 OR N; AND IN WHICH (I) X1 REPRESENTS N AND X2 REPRESENTS S, (II) X1 REPRESENTS S AND X2 REPRESENTS N, (III) X1 REPRESENTS CR7 AND X2 REPRESENTS S, (IV) X1 REPRESENTS S AND X2 REPRESENTS CR7; (V) X1 REPRESENTS NR8 AND X2 REPRESENTS N, (VI) X1 REPRESENTS N AND X2 REPRESENTS NR8, (VII) X1 REPRESENTS CR7 AND X2 REPRESENTS O, (VIII) X1 REPRESENTS O AND X2 ...

Method for controlling an automated transmission

A method of controlling an automated transmission with positioning cylinders ( 6, 8, 20 ) controlled by shift valves or venting valves ( 10, 12, 16, 18, 22, 24 ). At least one cut-off valve ( 4 ) is positioned in front of the shift or venting valves and a control device controls the valves while pressure pipes, which follow the cut-off valve ( 4 ), are connected with one another following the cut-off valve ( 4 ). Due to the fact that the cut-off valve ( 4 ), for reasons of design simplicity and cost, is generally designed as a simple 2/2 way valve which only allows pressure increase but not pressure reduction, the method provides control of the shift valves or ventilation or venting valves ( 16, 18 ), of a non activated positioning cylinder ( 8 ), so that the pressure pipe system is connected with an outflow pipe ( 14 ) for a pressure reduction in the pressure pipe system ( 30, 32, 34 ).

Phosphoinositide 3-kinase inhibitor compounds and methods of use

Compounds of Formulas Ia and Ib, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Tricyclic pi3k inhibitor compounds and methods of use

Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti- inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

Biheteroaryl compounds and their uses

La présente invention concerne des composés représentés par la formule i-i ainsi que des modes de réalisation et des sels correspondants qui sont destinés au traitement de maladies (notamment, de maladies neurodégénératives). R 1, r 2, r 3, x 1, x 2, a et la variable cy de la formule i-i possèdent tous la signification telle que définie dans la description. The present invention relates to compounds represented by formula i-i as well as embodiments and corresponding salts which are intended for the treatment of diseases (in particular, neurodegenerative diseases). R 1, r 2, r 3, x 1, x 2, a and the variable cy of the formula i-i all have the meaning as defined in the description.

Purifying device and method for elimination of xenobiotics in water

The present invention refers to a purifying device, adapted to perform a method of photochemical elimination of xenobiotics present in water. The purifying device comprises a photochemical reactor unit (2) having at least one inlet (2') for contaminated water and one outlet (2") for purified water, it provides a flow path for continuously flowing water from said inlet (2') to said outlet (2"), and is equipped with a radiation source module (6) providing ultraviolet radiation in a wavelength range ranging from 100 to 280 nm. The purifying device further comprises at least one membrane filtration unit (1) designed to perform ultra filtration and connected upstream of said photochemical reactor unit (2) via said inlet (2') and at least one device for supplying air or dioxygen to the water comprised in the photochemical reactor unit (2). Further, a purification method is provided, using the device of the invention.

Synthesis of a perfluoroalkyl bromide by photochemical bromination of the corresponding iodide.

Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them

Compounds of Formulas (Ia) and (Ib), and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula (Ia) and (Ib) for in vitro, in situ, and in vivodiagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

compound, pharmaceutical composition, method for treating cancer, uses of a compound, kit and invention

COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, MÉTODO PARA TRATAR CÂNCER, USOS DE UM COMPOSTO, KIT E INVENÇÃO. A presente invenção se refere a compostos de benzoxepino da Fórmula I que incluem estereoisômeros, isômeros geométricos, tautômeros, solvatos, metabólitos e sais farmaceuticamente aceitáveis dos mesmos, em que: Z1 é CR1 ou N; Z2 é CR2 ou N; Z3 é CR3 ou N; Z4 é CR4 ou N; e onde (i) X1 é N e X2 é S, (ii) X1 é S e X2 é N, (iii) X1 é CR7 e X2 é S, (iv) X1 é se X2 é CR7 ; (v) X1 é NR8 e X2 é N, (vi) X1 é N e X2 é NR8, (vii) X1 é CR7 e X2 é O, (viii) X1 é O e X2 é CR7, (ix) X1 é CR7 e X2 é C(R7)2, (x) X1 é C(R7 )2 e X2 é CR7 ; (xi) X1 é N e X2 é O, ou (xii) X1 é O e X2 é N, que são uteis para inibir lipídio quinases que incluem alfa p110 e outras isoformas de PI3K, e para tratar transtornos como câncer mediados por lipídio quinases. A presente invenção ainda se refere aos métodos de uso dos compostos da Fórmula I para diagnóstico, prevenção ou tratamento in vitro, in situ e in vivo de tais transtornos em células de mamífero, ou condições patológicas associadas. COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATING CANCER, USES OF A COMPOUND, KIT AND INVENTION. The present invention relates to Formula I benzoxepine compounds that include stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and where (i) X1 is N and X2 is S, (ii) X1 is S and X2 is N, (iii) X1 is CR7 and X2 is S, (iv) X1 is if X2 is CR7; (v) X1 is NR8 and X2 is N, (vi) X1 is N and X2 is NR8, (vii) X1 is CR7 and X2 is O, (viii) X1 is O and X2 is CR7, (ix) X1 is CR7 and X2 is C (R7) 2, (x) X1 is C (R7) 2 and X2 is CR7; (xi) X1 is N and X2 is O, or (xii) X1 is O and X2 is N, which are useful for inhibiting lipid kinases that include alpha p110 and other PI3K isoforms, and for treating disorders such as lipid-mediated cancer kinases . The present invention further relates to ...

Apparatus and method for reducing structural vibrations in a disc drive utilizing fusible alloys

An apparatus and method for reducing structural vibrations in a disc drive that incorporates a fusible alloy. A fusible alloy portion is constrained between a first and second structural alloy portion through conventional lamination techniques. A fusible alloy can be incorporated into any structural component of the disc drive, including a base plate and an information storage disc. Fusible alloys incorporated into the disc drive absorb energy transmitted by vibrations through anelastic deformation, i.e., through dislocation motion. Suitable fusible alloy materials may include but are not limited to: Lead-Tin, Indium-Tin and Indium-Bismuth.

Prenatal and lactation supplements to enhance central nervous system development of offspring.

Se describen suplementos prenatales y de lactancia para mujeres embarazadas y mujeres lactantes, los cuales incluyen una combinación de RRR-alfa-tocoferol, ácido docosahexaenoico (DHA), trans-luteína, fosfolípidos, y al menos un ligando activador de receptor nuclear diferente de RRR-alfa-tocoferol, DHA y trans-luteína. Los suplementos pueden mejorar el desarrollo de sistema nervioso central en un feto o neonato amamantándose.

Free-flowing powder fabric softening composition and process for its manufacture

ABSTRACT A free flowing spray-dried particulate fabric softening composition is provided which is readily dispersible in water. The composition comprises: (a) from about 5 to 40%, by weight, of a cationic quaternary ammonium softening compound; (b) from about 0.5 to 15%, by weight, of an anionic and/or a nonionic detergent compound; and (c) from about 45 to 85%, by weight, of urea; the balance being water.

Method for determining ambient pressure of motor vehicle e.g. commercial vehicle, involves venting transmission control device to environment through actuators and equalizing pressure of transmission control device to environment

The compressed air supply of a transmission control device (2) is interrupted in appropriate operating conditions, by an appropriate valve control. The transmission control device is vented to the environment (3) through the actuators (4-6). The pressure of the transmission control device is equalized to the environment after the expiration of a period of time. A sensor (15) is provided to detect the pneumatic pressure value of the transmission control device as the current ambient pressure.

Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use

Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of P13K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Thiazolopyrimidine p13k inhibitor compounds and methods of use

Compounds of Formulas Ia and Ib, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. (see formula Ia) (see formula Ib) Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Benzoxazepin PI3K inhibitor compounds and methods of use

Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z 1 is CR 1 or N; Z 2 is CR 2 or N; Z 3 is CR 3 or N; Z 4 is CR 4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Phosphoinositide 3-kinase inhibitor compounds and methods of use

Biheteroaryl compounds and uses thereof

The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R

Pharmaceutical compounds

Benzoxazepin pi3k inhibitor compounds and methods of use

The invention relates to benzoxazepin compounds of Formula (I) including stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: Z 1 is CR 1 or N; Z 2 is CR 2 or N; Z 3 is CR 3 or N; Z 4 is CR 4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring which compounds have anti-cancer activity, and more specifically, inhibit PI3 kinase activity.

Phosphoinositide 3-kinase inhibitor compounds and methods of use

Process for the preparation of tricyclic PI3K inhibitor compounds and methods for using the same for the treatment of cancer

The present disclosure provides for methods for preparing tricyclic PI3K inhibitor compounds in high yield and purity in aqueous solvent systems.

Fused ring compounds

Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.

Process for the preparation of tricyclic PI3K inhibitor compounds and methods for using the same for the treatment of cancer

The present disclosure provides for methods for preparing tricyclic PI3K inhibitor compounds in high yield and purity in aqueous solvent systems.

Pharmaceutical compounds

High refractive index and high impact resistant polythiourethane/urea material, method of manufacturing same and its use in the optical field

Benzoxazepin PI3K inhibitor compounds and methods of use

The invention relates to benzoxazepin compounds of Formula I including stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: Z 1 is CR 1 or N; Z 2 is CR 2 or N; Z 3 is CR 3 or N; Z 4 is CR 4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring which compounds have anti-cancer activity, and more specifically, inhibit PI3 kinase activity.

Pyrimidine derivatives for use as inhibitors of pi3k and relevant preparation process, pharmaceutical composition, use, kit,and product

Benzoxepin pi3k inhibitor compounds and methods of use.

Los compuestos de benzoxepina de la fórmula I, incluidos sus estereoisómeros, isómeros geométricos, tautómeros, solvatos, metabolitos y sales farmacéuticamente aceptables, en los que: Z1 es CR1 o N; Z2 es CR2 o N; Z3 es CR3 o N; Z4 es CR4 o N; y en los que (i) X1 es N y X2 es S, (ii) X1 es S y X2 es N, (iii) X1 es CR7 y X2 es S, (iv) X1 es S y X2 es CR7 (V) X1 es NR8 y X2 es N, (vi) X1 es N y X2 es NR8, (vii) X1 es CR7 y X2 es O, (viii) X1 es O y X2 es CR7, (ix) X1 es CR7 y X2 es C(R7)2, (x) X1 es C(R7)2 y X2 es CR7 (xi) X1 es N y X2 es O, o (xii) X1 es O y X2 es N, son útiles para inhibir las lípidoquinasas, incluidas la p110 alfa y otras isoformas de la PI3K, y para tratar trastornos tales como el cáncer mediado por las lípido-quinasas. Se describen métodos de uso de los compuestos de la fórmula I para el diagnóstico, la prevención o el tratamiento de dichos trastornos "in vitro", "in situ" e "in vivo" en células de mamíferos, o de estados patológicos asociados.

Pharmaceutical compounds.

Se describen compuestos de las Fórmula Ia y Ib, (ver fórmula (Ia)) (ver fórmula (Ib)) y estereoisómeros, isómeros geométricos, tautómeros, solvatos, metabolitos y sales farmacéuticamente aceptables de los mismos, que son útiles para inhibir las cinasas lípidas que incluyen PI3K, y para tratar trastornos tales como cáncer mediado por cinasas de lípido. Se describen métodos para usar los comuestos de la Fórmula Ia y Ib para diagnóstico in vitro, in situ, e in vivo, prevención o tratamiento de tales trastornos en células de mamíferos, o condiciones patológicas asociadas.

Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use

Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.