HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

Analogs of human growth hormone-releasing hormone, their preparation and use

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMAN GROWTH HORMONES RELEASE HORMONE-SIMILAR, THEIR PRODUCTION AND USE

HUMANE WACHSTUMSHORMONE FREISETZENDE HORMONANALOGE, DEREN HERSTELLUNG UND VERWENDUNG

HUMANE WACHSTUMSHORMONE FREISETZENDE HORMONANALOGE, DEREN HERSTELLUNG UND VERWENDUNG

Analogs of human growth hormone-releasing hormone, their preparation and use

Growth hormone-releasing hormone analogs having the amino acid sequence of the formula: Dat-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr10-R11-R12-VAL-Leu-Ala-Gln-Leu-Ser-Ala-R20-R21-Leu-Leu-Gln-Asp-Ile-Nle-Asp-R29-NH2 (I), wherein R11 is hArg, Gab or Gap; R12 is hArg, Orn, Gab or Gap; R20 is hArg, hArg, Gab or Gap; R21 is hArg, Orn, Gab or Gap; R29 is D-Arg, hArg, Gab or Gap; and their pharmaceutically acceptable salts. Said peptides are potent and selective stimulators of GH release and they are highly resistant to enzymatic degradation. Said peptides are prepared using the solid phase synthesis method, by introducing suitable derivatives of lysine, 2,4-diaminobutyric acid or 2,3-diaminopropionic acid at appropriate positions in the peptide chain attached to a polymeric support, deprotecting side-chain amino groups and reacting free amino groups with a guanidinating agent, removing all remaining t-butyloxycarbonyl protective groups, and cleaving the synthesized peptide from the support, followed ...

New peptides - analogs of human growth hormone-releasing hormone

Growth hormone-releasing hormone analogs having the amino acid sequence of the formula: Dat-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr10-R11-R12-VAL-Leu-Ala-Gln-Leu-Ser-Ala-R20-R21-Leu-Leu-Gln-Asp-Ile-Nle-Asp-R29-NH2 (I), wherein R11 is hArg, Gab or Gap; R12 is hArg, Orn, Gab or Gap; R20 is hArg, hArg, Gab or Gap; R21 is hArg, Orn, Gab or Gap; R29 is D-Arg, hArg, Gab or Gap; and their pharmaceutically acceptable salts. Said peptides are potent and selective stimulators of GH release and they are highly resistant to enzymatic degradation. Said peptides are prepared using the solid phase synthesis method, by introducing suitable derivatives of lysine, 2,4-diaminobutyric acid or 2,3-diaminopropionic acid at appropriate positions in the peptide chain attached to a polymeric support, deprotecting side-chain amino gorups and reacting free amino groups with a guanidinating agent, removing all remaining t-butyloxycarbonyl protective groups, and cleaving the synthesized peptide from the support, followed by purification and optionally, converting the peptide into a pharmaceutically acceptable salt.

Novel peptides - analogues of a human hormone responsible for release of the growth hormone

Humane wachstumshormone freisetzende hormonanaloge, deren herstellung und verwendung