19-02-2015 дата публикации
Номер: US20150050213A1
The present application provides compositions and methods for imaging traumatic brain injury using PET. The present application discloses using PET ligands targeting infiltrating neutrophils, such as a ligand of FPR, is useful for imaging inflammation. In one aspect, the ligand and imaging agent cFLFLF-PEG-Cu. 1. A method for imaging inflammation in the brain , said method comprising administering to a subject a composition comprising a ligand for the formyl peptide receptor , wherein said ligand comprises a neutrophil-binding peptide linked to a hydrophilic polyethyleneglycol (PEG) moiety , and a detectable label , and submitting said subject to an imaging technique.2. The method of claim 1 , wherein said detectable label is a radionuclide selected from the group consisting of In claim 1 , In claim 1 , Lu claim 1 , F claim 1 , Fe claim 1 , Cu claim 1 , Cu claim 1 , Cu claim 1 , Ga claim 1 , Ga claim 1 , Y claim 1 , Y claim 1 , Zr claim 1 , Tc claim 1 , Tc claim 1 , Tc claim 1 , I claim 1 , I claim 1 , I claim 1 , I claim 1 , I claim 1 , Gd claim 1 , P claim 1 , C claim 1 , N claim 1 , O claim 1 , Re claim 1 , Re claim 1 , Mn claim 1 , mMn claim 1 , Co claim 1 , As claim 1 , Br claim 1 , Br claim 1 , mRb claim 1 , Sr claim 1 , or other gamma- claim 1 , beta- claim 1 , or positron-emitters.3. The method of claim 2 , wherein said label is Cu.4. The method of claim 1 , wherein the neutrophil-binding peptide is cinnamoyl-F(D)LF(D)LF.5. The method of claim 4 , wherein the neutrophil-binding peptide is linked to said PEG via a lysine.6. The method of claim 5 , wherein the neutrophil-binding peptide linked to PEG via a lysine has the formula cF(D)LF(D)LFK-PEG.7. The method of claim 1 , wherein said imaging technique is selected from the group consisting of fluorescence claim 1 , positron emission tomography (PET) claim 1 , magnetic resonance imaging claim 1 , single photon emission computed tomography (SPECT/CT) claim 1 , intravital laser scanning microscopy claim 1 , ...
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