AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS

AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Method and system for queuing uncalled web based on path

The present invention provides method and system of queuing un-accessed web pages based on route during the world wide web processing course. All the routes from the "seed" URL to accessed relevant web pages are marked as "optimized route set", while the routes from the "seed" URL to un-accessed web pages are marked as "partial route set". All the access web pages are classified and marked with their attributive classes. Some training-statistics model is used to characterize the common route mode of routes in the "optimized route set"; the statistics model is used in estimating the "partial route set" and the estimation results are used in queuing all the un-accessed web pages.

Method and device for generating hierarchy visual structure of semantic network

This invention provides a method of visual layer structure of semantic producing network and device, the method of browsing semantic network and semantic network browse. The relating semantic networkincludes many ideas and the relation examples that connect two ideas. And the method includes: according to the connection relation of the ideas in the semantic network, assure the similarity of the two ideas; orderly unite the ideas with high similarity in order to form the visual layer structure of the semantic network.

TRIAZOLE COMPOUNDS AS KSP INHIBITORS

The present invention provides triazole compounds of Formula (I) : as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I), and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula (I).

Optical power measurement method

The invention discloses a light power measuring method with a log ratio amplifying circuit combined with software. Measuring process is: constructing light power calculating formula P=K<3>beta+C<3> according to the log ratio amplifying circuit in the measuring system; configuring an AD converter according to wavelength of measured light source; connecting the measured light source with the light end, picking a signal received at the light end, the AD converter reading in data N times circularly after photoelectric conversion and log amplification, solving an average value beta of N conversion values; judging whether value of beta exceeds measuring range, if so, measurement is over; if not, dividing the light source measured according to power of the standard light source; comparing beta value with an edge value of the standard light source, selecting corresponding K<3> and C<3> according to location where beta is; introducing determined beta, K<3> and C<3> values to the light power calculating ...

Weldable conductive silver paste and synthesis method thereof

The invention provides weldable conductive silver paste and a synthesis method thereof. The weldable conductive silver paste comprises the following components in percentage by mass: 12% of resin liquid; 7% of diethylene glycol monomethyl ether; and 81% of silver-coated copper beam powder. The technical scheme provided by the invention has the advantages of low cost and environmental protection.

Preparation method of gaseous modified spherical silicon dioxide powder

The invention relates to a preparation method of gaseous modified spherical silicon dioxide powder, which comprises the following steps: selecting spherical silicon dioxide micro-powder as a raw material, performing purification and activation pretreatment on the spherical silicon dioxide powder by adopting a gaseous modification method, and then performing gaseous modification treatment on a silane coupling agent, thereby obtaining the gaseous modified spherical silicon dioxide powder. Two stages of reaction kettles are used for respectively providing different gaseous heat treatment environments, so that sufficient contact between a treatment agent and the surface of spherical silicon dioxide is ensured. On one hand, continuous production of modification pretreatment and modification treatment processes of the silicon dioxide powder can be realized, and on the other hand, continuous production in a workshop can be realized; and the modified spherical silicon dioxide micropowder with low ...

Prefetching RDF triple data

Query requests for RDF triples are obtained, wherein the query request(s) contain(s) at least one triple pattern; for each triple pattern, the corresponding elementary pattern is determined, and each triple pattern is converted to a weighted elementary pattern. The occurrence frequency of each elementary pattern is computed based on the weighted elementary patterns; at least one elementary pattern is chosen at least according to the occurrence frequency; and the RDF triples corresponding to the chosen at least elementary pattern are prefetched into the buffer. The corresponding apparatus is also provided. With the above method and apparatus, the frequently accessed RDF triples can be determined and prefetched into the buffer, which improves the query efficiency.

Method and system for automatically evaluating the quality of medical records

A method, a system, and a computer readable article of manufacture tangibly embodying computer readable instructions for executing a computer implemented method for automatically evaluating the quality of a medical record. The method includes: generating temporary facts from a medical record to be evaluated; constructing a query to a knowledge base of standard facts of standard medical records from the temporary facts; executing the query to the knowledge base by using a reasoning engine; and determining the quality of a medical record to be evaluated based on the result of the query.

BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

PYRIDINE AND PYRAZINE DERIVATIVES AS PROTEIN KINASE MODULATORS

The present invention provides a compound of formula (I), and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a diseease or condition mediated by CDK9.

Manual forming device that bends of sheet material

The utility model relates to a small -size hem spare molding processing technology field, in particular to manual forming device that bends of sheet material. Left riser and right riser are welded respectively to both ends about the device's machine body base upper surface, are equipped with the bevel protractor outside the left riser, and the welding of machine body base upper surface rear portion has fixed platen, and hub connection levogyration board is sold through a left side in left riser inboard, and the inboard right pin roll of passing through of right riser connects the dextrorotation board, welding operation handle on the dextrorotation board, and the welding is bent and is revolved the roof beam between levogyration board and the dextrorotation board. The utility model discloses a can process the small -size hem spare of complicated shapes such as " L ", " mouth ", " U ", " own ", " nine ", " second ", have a roll board working ability, simple structure, it is small, convenient ...

Process and equipment for pouring refractory lining of gas pipeline of gasification furnace

The invention discloses a pouring process and equipment for a refractory lining of a gas pipeline of a gasification furnace, the pouring equipment comprises a fixed bottom plate and a servo motor, the servo motor is fixedly arranged at the top of the fixed bottom plate, and an output shaft of the servo motor is fixedly connected with a rotating shaft through a coupler, and the invention relates to the technical field of gasification furnaces. According to the pouring process and pouring equipment for the refractory lining of the gas pipeline of the gasification furnace, the annular pouring mechanism, the ascending mechanism and the separate paving mechanism are arranged at the top of the fixed bottom plate, so that the equipment can perform annular pouring from bottom to top through cooperation of the annular pouring mechanism, the ascending mechanism and the separate paving mechanism; the effects of filling pouring of the castable and sequential layer-by-layer stacking forming are achieved ...

Heat dissipation system for multi-chip interconnection structure

The invention relates to the technical field of chip heat dissipation, and provides a heat dissipation system for a multi-chip interconnection structure, and the system comprises a chip interconnection layer which comprises a plurality of crystal grains; and the heat dissipation layer is arranged on the chip interconnection layer, the heat dissipation layer comprises a plurality of heat dissipation elements, and at least one of the plurality of heat dissipation elements is arranged on one of the plurality of crystal grains. According to the invention, the heat dissipation capability of a heat dissipation system can be effectively improved, the heat dissipation requirement of a multi-chip interconnected wafer-level chip with the overall power reaching 25kW and the single-crystal-grain power reaching 500W is met, and the heat dissipation problem of a high-heat-source area of the chip is better solved. And the heat dissipation elements can be constructed into different structures so as to ...

3-(AMINOARYL)-PYRIDINE COMPOUNDS

The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are pharmaceutical compositions containing these compounds and methods of treating a disease or condition mediated by CDK9 using these compounds and compositions.

System and method for realizing metadata search

The invention discloses a system and a method for realizing metadata search. The system comprises a receiving module, an inquiry processor and an output module, wherein the receiving module is used for receiving a search inquiry for multiple metadata resources, wherein text information in the metadata resources is appointed in the search inquiry, and structure information among the metadata resources is not appointed, or partial structure information among the metadata resources is only appointed; the inquiry processor is used for analyzing the search inquiry and searching the related metadataresources and the structure information among the related metadata resources according to the analysis for the search inquiry so as to form a search result, wherein the search result contains the integrated structure information among the related metadata resources; and the output module is used for outputting the search result so as to realize the fuzzy structure search for the metadata resources.

Method and device for treating natural language problem

The invention discloses a method and device for treating a natural language problem. The method for treating the natural language problem of the invention comprises the steps of: detecting a named entity in the natural language problem; extracting information related to an answer in the natural language problem; retrieving in chained data according to the detected named entity; generating candidate answers according to a retrieving result; analyzing the candidate answers according to the information related to the answer to obtain the values of the characteristics of the candidate answers; and integrating the values of the characteristics of the candidate answers to evaluate each candidate answer.

Device for preparing isocyanate by pyrolyzing aminoalkyl esters

The invention belongs to the technical field of organic chemical industry production, and relates to a device for preparing isocyanate by pyrolyzing aminoalkyl esters. A major structure comprises a pyrolysis reaction kettle, three tower columns, two H distilling heads and three receiving pots; the top part of the pyrolysis reaction kettle is communicated with the bottom of sieve plate tower columns by a tower body support; the top part of a lower sieve plate tower column is communicated with the bottom of an oblique H distilling head; the top part of the oblique H distilling head is connectedwith the bottom of a middle packing tower column; an outlet of the oblique H distilling head is respectively communicated with a product receiving pot; the top end of the middle packing tower column is communicated with the bottom end of a horizontal H distilling head; the top part of the horizontal H distilling head is communicated with the bottom of an upper packing tower column; an outlet of the ...

XML query method and XML query system for variable-model XML documents

The invention relates to an XML query method and an XML query system, in particular to an XML query method and an XML query based on one or a plurality of variable-model XML documents. The method comprises the following steps: extracting the nest relation among elements of documents; extracting anchor points of the elements of the documents and extracting the nest relation among the anchor points;receiving the input query, and applying the pre-set constraint rule to the query; concluding the tree structure of the queried element which is contained in the XML query in each document of one or multiple XML documents based on the extracted nest relation among the elements; and writing XQuery/XPath of each document of the one or the multiple XML documents based on the tree structure, thereby the query result of each document can be obtained.

Wafer-level integrated structure with separated substrate

The invention relates to the technical field of semiconductor manufacturing, and provides a wafer-level integrated structure with a separated substrate, and the structure comprises a first printed circuit board; a plurality of mutually separated substrates arranged on the first surface of the first printed circuit board; an adapter plate disposed on the plurality of substrates; and a plurality of chips which are arranged on the adapter plate. According to the structure, a plurality of substrates which are separated from one another are used, the size problem of the substrates can be solved, and the distance between C4 convex blocks fanned out of the adapter plate can be increased through wiring in the substrates.

Variable-frequency energy-saving control system for circulating pump motor

The invention discloses a circulating pump motor variable-frequency energy-saving control system, which comprises a circulating water pump, a variable-frequency module, a variable-frequency control module and a variable-frequency control module, the data acquisition module is used for monitoring temperature data and load data of the variable frequency motor and water yield data of the circulating water pump in real time; the analysis control module is used for receiving and storing the data acquired by the data acquisition module, and predicting, controlling and executing the action of the frequency conversion module at the next moment according to the data; the alarm display module is used for displaying the data, judging the data and giving an alarm according to a judgment result; by reasonably adjusting the adjustment of the circulating pump variable frequency motor under the circulating pump variable frequency, the plant power consumption is reduced, the plant power consumption rate ...

PI3K-alpha inhibitors and methods of use thereof

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods of inhibiting P13K-alpha enzyme activity using the compounds and compositions of the present disclosure. The present disclosure further relates to, but is not limited to, methods of treating conditions associated with PI3K-alpha signaling with the compounds and compositions of the present disclosure.

Manufacturing and using method of accurate orthodontic bracket bonding model based on 3D printing and cutting technology

The invention provides an accurate orthodontic bracket bonding method based on a 3D printing and cutting technology, which is characterized by comprising the following steps: S1, carrying out digital scanning on the interior of the oral cavity of a patient to obtain an oral cavity digital scanning model; and S2, positioning the metal bracket on the basis of the digital model. (2); s3, printing a bonding template (1) by using a 3D printer, and cutting bracket positioning holes; the invention further provides a using method of the accurate orthodontic bracket bonding model based on the 3D printing and cutting technology, and the using method is characterized by comprising the following steps that S1, the 3D printed bonding template (1) is used clinically; and S2, directly bonding the metal bracket on the surface of the dental crown according to the bracket positioning holes (1) in the bonding template. According to the invention, the teeth can be accurately positioned in the three-dimensional ...

System and method for interactive browsing

A method for achieving interactive browsing includes steps performed by a computer coupled to a knowledge base and a document database. The knowledge base stores a plurality of terms and information relating to each term, and the document database stores a plurality of documents. The steps include acquiring terms in which a user has interest; extracting information relating to the terms in which the user has interest from the knowledge base in order to display the information in a first display part of a user interface; and extracting documents containing the terms in which the user has interest from the document database in order to display a list of extracted documents in a second display part of the user interface.

Pyridine and pyrazine derivatives as protein kinase modulators

The present invention provides a compound of formula (I), and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a diseease or condition mediated by CDK9.

Triazole compounds as KSP inhibitors

The present invention provides triazole compounds of Formula (I) : as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I), and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula (I).

OBTAINING HIERARCHICAL INFORMATION OF PLANAR DATA

The invention provides a method and apparatus for obtaining hierarchical information of planar data, the method comprising: mapping at least one data item from a same data set in the planar data to at least one node in a tree structure formed by a structured terminology system; obtaining at least one sub tree structure in the tree structure, each of the at least one sub tree structure taking the at least one node as all of its leaf node; selecting a target tree structure from the at least one sub tree structure; and obtaining hierarchical information in the target tree structure. An apparatus corresponding to the above method is also provided. With the above method and apparatus, hierarchical information of data items may be obtained from planar organized data to facilitate subsequent and further analysis and management.

High-power evaporative cooling SiC power device

The invention relates to the technical field of thermal management of SiC power devices, in particular to a high-power evaporative cooling SiC power device which comprises a liquid collection assembly, a gas collection assembly and a shell assembly. The bottom of the liquid collection assembly and the bottom of the gas collection assembly are fixedly arranged on the two sides of the upper surface of the shell assembly respectively, the liquid collection assembly is parallel to the gas collection assembly, the SiC power module is fixedly arranged in the shell assembly, and the liquid collection assembly and the gas collection assembly are both communicated with the shell assembly; through the integrated design, the high-power evaporative cooling SiC power device is miniaturized, the low-boiling-point cooling liquid can vertically impact and make contact with the SiC power module at zero distance, the middle heat transfer link is reduced, transient heat can be rapidly dissipated, efficient ...

Method for spraying concrete to TBM tunnel primary support

The invention discloses a TBM tunnel primary support concrete spraying method, which is characterized in that a tunnel inner contour imaging module is mounted on one side of a concrete spraying nozzle, and is electrically connected with a tunnel contour data processing module; the method comprises the following specific steps: acquiring an original image of the inner contour of a tunnel, spraying concrete, detecting the thickness of a concrete spraying operation area, evaluating the quality of the concrete spraying operation, and repeating the steps until the thickness and the flatness of the sprayed concrete reach design indexes. According to the invention, the thickness and flatness of sprayed concrete in a sheet area can be rapidly and accurately detected, and the detection efficiency, precision and range are improved.

PREFETCHING RDF TRIPLE DATA

Query requests for RDF triples are obtained, wherein the query request(s) contain(s) at least one triple pattern; for each triple pattern, the corresponding elementary pattern is determined, and each triple pattern is converted to a weighted elementary pattern. The occurrence frequency of each elementary pattern is computed based on the weighted elementary patterns; at least one elementary pattern is chosen at least according to the occurrence frequency; and the RDF triples corresponding to the chosen at least elementary pattern are prefetched into the buffer. The corresponding apparatus is also provided. With the above method and apparatus, the frequently accessed RDF triples can be determined and prefetched into the buffer, which improves the query efficiency.

OBTAINING HIERARCHICAL INFORMATION OF PLANAR DATA

The invention provides a method and apparatus for obtaining hierarchical information of planar data, the method comprising: mapping at least one data item from a same data set in the planar data to at least one node in a tree structure formed by a structured terminology system; obtaining at least one sub tree structure in the tree structure, each of the at least one sub tree structure taking the at least one node as all of its leaf node; selecting a target tree structure from the at least one sub tree structure; and obtaining hierarchical information in the target tree structure. An apparatus corresponding to the above method is also provided. With the above method and apparatus, hierarchical information of data items may be obtained from planar organized data to facilitate subsequent and further analysis and management.

Intelligent infusion device based on wireless network

The invention discloses an intelligent infusion device based on a wireless network, comprising a dropping funnel (20), a flexible pipe (8), a dripping speed monitoring device (1), a display screen (2), a wireless transmit-receive device (3), a dripping speed controller (4), a microcontroller MCU (5) and a movable type infusion controller (6), wherein the flexible pipe (8) is communicated with both ends of the dropping funnel (20); the dripping speed monitoring device (1), the display screen (2) and the microcontroller MCU (5) are integrated on a circuit board (90), and the circuit board (90) is arranged on the dropping funnel (20); and the wireless transmit-receive device (3) and the dripping speed controller (4) are arranged on the flexible pipe (8) positioned below the dropping funnel (20) and are respectively connected with the microcontroller MCU (5) arranged on the circuit board (90) through lead wires. The invention realizes the whole-course intelligent control in the infusion process ...

Biaryl amide compounds as kinase inhibitors

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

File classifying management system and method for operation system

The document classifying management system maps the physical stored documents to one or several logic categories for management according to the contents of the documents. By means of one desk top document managing device in operation system, the documents under various logic categories are exhibited to the user. In this way, the user can search interested document without needing contact with thousands of documents. The present invention can raise the usability of the document managing system, create friendly man-computer interface and facilitate the user.

System and method for realizing metadata search

The invention discloses a system and a method for realizing metadata search. The system comprises a receiving module, an inquiry processor and an output module, wherein the receiving module is used for receiving a search inquiry for multiple metadata resources, wherein text information in the metadata resources is appointed in the search inquiry, and structure information among the metadata resources is not appointed, or partial structure information among the metadata resources is only appointed; the inquiry processor is used for analyzing the search inquiry and searching the related metadata resources and the structure information among the related metadata resources according to the analysis for the search inquiry so as to form a search result, wherein the search result contains the integrated structure information among the related metadata resources; and the output module is used for outputting the search result so as to realize the fuzzy structure search for the metadata resources ...

Filling and sealing equipment

The invention discloses potting equipment, which comprises a potting device, which comprises an upper potting table and a lower potting table, the lower potting table is used for placing a to-be-potting potting piece, the upper potting table contains a to-be-filled material, and the upper potting table is used for potting the to-be-potting potting piece with the to-be-filled material; at least one of the upper potting table and the lower potting table can ascend and descend so as to be close to or away from each other, and therefore materials can be extruded into the potting piece conveniently. Taking a to-be-potted potting piece as a punched green ceramic chip and a material as electronic paste as an example, when the potting device is used, the green ceramic chip is placed on the lower potting table, the upper potting table and the lower potting table are driven to move towards each other, the electronic paste is filled into the conductive through hole in the green ceramic chip through ...

Aminoheteroaryl benzamides as kinase inhibitors

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

3-(aminoaryl)-pyridine compounds

The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are pharmaceutical compositions containing these compounds and methods of treating a disease or condition mediated by CDK9 using these compounds and compositions.

Aminoheteroaryl benzamides as kinase inhibitors

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Radio frequency identification-based electrocar anti-theft lock

The invention discloses a radio frequency identification-based electrocar anti-theft lock, comprising a key with a radio frequency identification tag, a radio frequency identification reader and a controller used for controlling the electrocar to start, wherein the key is inserted in or pulled out from the radio frequency identification reader, and the radio frequency identification reader is connected with the controller. Compared with the prior art, the electrocar anti-theft lock comprises the key with the radio frequency identification tag and the radio frequency identification reader, and is characterized in that the radio frequency identification tag has a globally unique identification code and can not be copied is fully utilized, thus the anti-theft problem is substantially solved. Besides, the key is pulled out from the radio frequency identification reader only when the electrocar is required to be locked, thus providing great convenience for people.

Music pillow

The invention relates to pillows, in particular to a music pillow. A player is arranged in the music pillow, and light music and an alarm clock program are set in the player. The music pillow is further provided with a remote controller used for controlling the player in a wireless mode. The remote controller is pressed down so that the player can play music, and people can be helped to enter into a sleeping state as soon as possible. Meanwhile, an alarm clock is also set through the remote controller, and the player can play the light music in the same way to wake up people at the set alarm clock time. The music pillow can effectively improve the sleeping quality of people, and is suitable for people who are often sleepless.

DETECTION DEVICE FOR CHINESE MEDICAL INSPECTION DIAGNOSIS

The present invention is to provide a monitoring device for inspection diagnosis in traditional Chinese medicine, comprising: a housing, a light source and a shooting structure, the said light source and shooting structure are positioned in the housing, a photoconductive component is positioned in the said housing, the said photoconductive component comprising at least one photoconductive layer, the said light source is positioned inside the photoconductive layer or on the side cross section of the photoconductive layer, with the diffuse reflection of the photoconductive component the said light source forms a area light source. In the present invention, as the photoconductive component is adopted in light transmission, the point light is converted to area light so that a soft, stable and uniform illumination environment similar to the natural light comes into being in the monitoring device. 1. A monitoring device for inspection diagnosis in traditional Chinese medicine , comprising: a housing , a light source and a shooting structure , the light source and shooting structure are positioned in the housing , characterized in that a photoconductive component is positioned in the housing , the photoconductive component comprising at least one photoconductive layer , the light source is positioned inside the photoconductive layer or on a side cross section of the photoconductive layer , wherein a diffuse reflection through the photoconductive component of the said light source forms an area light source.2. The monitoring device for inspection diagnosis in traditional Chinese medicine according to characterized in that the photoconductive layer is composed by a photoconductive plate.3. The monitoring device for inspection diagnosis in traditional Chinese medicine according to characterized in that the photoconductive component further includes a uniform light layer outside the photoconductive layer.4. The monitoring device for inspection diagnosis in traditional Chinese ...

Method and apparatus for data processing

This application generally relates to data processing methods and apparatus. One data processing method disclosed herein comprises: creating a Writable Snapshot based on data modification; creating a plurality of Read-Only (“RO”) Snapshots by cloning the Writable Snapshot at distinct predetermined creation-times; receiving a data inquiry request; and conducting the data inquiry through indexing, in a RO Snapshot with a latest creation-time. This approach achieves separation of data modification and data inquiry, enabling efficient real-time updating. Further, by fast indexing and invert indexing, inquiry efficiency is further improved. Additionally, data is stored in data columns, wherein each column may be divided into multiple data blocks according to a fixed block size, and each data block has a same length. When modifying data, effect of the modification may be limited to the data blocks being modified, without affecting the other data blocks, which reduces resource consumption incurred ...

POWER BATTERY PACK SAFETY PREVENTION AND CONTROL SYSTEM FOR ELECTRIC VEHICLE AND CONTROL METHOD

Disclosed are a power battery pack safety prevention and control system for an electric vehicle and a control method. The power battery pack safety prevention and control system includes a signal collection device, a master controller, and a stepwise prevention and control actuator. The master controller includes a fault diagnosis device, a cell thermal runway determination device, and a battery pack thermal runway spread determination device which are respectively electrically connected to the stepwise prevention and control actuator and send different control instructions to the stepwise prevention and control actuator. The stepwise prevention and control actuator can perform different levels of prevention and control actions according to different control instructions sent by the fault diagnosis device, the cell thermal runway determination device, and the battery pack thermal runway spread determination device. The power battery pack safety prevention and control system for an electric vehicle can provide an active prevention and control measure and a passive prevention and control measure, accurately activate a prevention and control mechanism according to an actual situation of an accident in combination with the prevention and control capability of the prevention and control system, maximize the effect of the safety protection, and ensure the safety of the passenger in the electric vehicle.

Pyridine and pyrazine derivatives as protein kinase modulators

The present invention provides a compound of formula (I), and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a diseease or condition mediated by CDK9.

Triazole compounds as KSP inhibitors

The present invention provides triazole compounds of Formula (I) : as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I), and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula (I).

High-temperature-resistance dipping method for hydrogen chloride synthetic furnace graphite combustion chamber

The invention discloses a high-temperature-resistance dipping method for a hydrogen chloride synthetic furnace graphite combustion chamber, which is characterized in that the hydrogen chloride synthetic furnace graphite combustion chamber is subjected to high-temperature-resistance dipping by a polysiloxane organosilicon water-soluble dispersion liquid, the hydrogen chloride synthetic furnace graphite combustion chamber product is dipped, solidified and performed heat drying step by step, the antioxidation performance of the hydrogen chloride synthetic furnace graphite combustion chamber product under a high temperature state is increased, mechanical strength and corrosion resisting stability of the graphite combustion chamber product are enhanced, and the usage life of the hydrogen chloride synthetic furnace graphite combustion chamber is prolonged.

Thermoplastic elastic body shoe material and production method

The invention relates to the field of shoe materials, in particular to a thermoplastic elastic shoe material which is composed of PSBS, naphthenoid oil, polyethylene, calcium carbonate, AC vesicants, pigments and partial cross linkers; the part by weight of the raw materials are as follows: 90 to 110 parts by weight of the PSBS, 90 to 110 parts by weight of the naphthenoid oil, 25 to 35 parts by weight of the polyethylene, 25 to 35 parts by weight of the calcium carbonate, 0.001 to 0.004 part by weight of the AC vesicants, 0.01 to 0.5 part by weight of the pigments and 0.01 to 0.5 part by weight of the partial cross linkers. The shoe material can be recycled and reused, is light in ratio and high in hardness, complies with national standards, is low in cost and simple in manufacturing, isfavorable in rebound elasticity and smaller in heat contractibility and compression set; is favorable in mechanical property, higher in tearing strength and tensile strength and moderate in hardness.

Method and apparatus for searching information resource

The invention discloses a method used for searching of information resource, and a device thereof. The method comprises the following steps: according to the query currently used for the first type information resource, the query result of the first type information resource, one or more lateral surfaces of the first type information resource, metadata under each lateral surface, the first type information resource and the relationships of other type information resources at least comprising the second type information resource are obtained; the obtained query result of the first type information resource, one or more lateral surfaces of the first type information resource, the metadata under each lateral surface, the first type information resource and the relationships of the other typeinformation resources at least comprising the second type information resource are returned to the user. According to the method and the device, the user can perform the complex information resource search ...

Signal integration device and communication system

The invention provides an integrating device of video signal, sound signal and data signal and a communication system, comprising a modulator, a signal processor and an adder, wherein the modulator modulates the video signal to generate a first signal, the signal processor codes and modulates the sound signal and the data signal to generate a second signal, and the adder adds the first signal to the second signal to generate a transmission signal, which is transmitted by optical fiber.

Vertical power supply structure of wafer level packaging structure

The invention relates to a vertical power supply structure of a wafer-level packaging structure, and the structure comprises a circuit board which is provided with a fourth rewiring layer on the front surface, and is internally provided with a longitudinal metal wire electrically connected with the fourth rewiring layer; the second-stage voltage regulation module is arranged on the back surface of the circuit board and is electrically connected with the longitudinal metal wires in the circuit board; the power supply connector is electrically connected with the second-stage voltage regulation module; the PCB is electrically connected with the power supply connector; and the first-stage voltage regulation module is electrically connected with the PCB. The vertical power supply structure can reduce the wiring length of a power supply path.

method to validate consistency of component business model maps

A method is described for using descriptive logic (DL) representations to validate consistency in component business model (CBM) maps. Semantic constraints are generated from a semantic model of a component business model meta-model and inconsistency conditions of CBM maps. The semantic model of the CBM meta-model is applied to transform CBM maps into corresponding semantic representations. An inference engine applies the semantic constraints to the semantic representations to determine inconsistencies between one CBM map and another and between a CBM map and the component business model meta-model.

Optical cable rapid-connection protection device

The invention discloses an optical cable rapid-connection protection device, which comprises protective sleeves, anti-slide slots, baffle plates, a threading pipe, a transparent cover and threads. The protective sleeves are provided with a plurality of equally-spaced anti-slide slots. The transparent cover covers the threading pipe. A pair of parallel baffle plates is led out of the two ends of the threading pipe. The protective sleeves are screwed into the threading pipe through the threads to be fixed to the threading pipe in a fitting mode. According to the optical cable rapid-connection protection device, the threading pipe is of an open-loop structure. During use, first, the two protective sleeves respectively sleeve two optical cables, and the optical cables are simply connected. After that, the interface parts of the optical cables are placed in the threading pipe, and the transparent cover is clamped onto a clamping block of the threading pipe to cover and fix the optical cables ...

Method for preparing isocyanate

The invention belongs to the technical field of organic compound preparation, and relates to a method for preparing isocyanate by pyrolyzing aminoalkyl esters. The method comprises the following steps: evenly mixing hexamethylene1, 6-dicarbamate, dioctylphthalate and zinc-zinc oxide into a mixture according to a mass ratio of 25:50:1; adding the mixture into a reaction kettle; replacing air in a reaction system by nitrogen, and then entering a program operation; improving a reaction temperature to 220 DEG C in 1 to 2 hours, and adjusting system vacuum degree to -0.090MPa; starting to collect isocyanate product after pyrolyzing for 1 to 1.5 hours under the condition of maintaining the temperature and the pressure; and improving the temperature to 240 to 260 DEG C in 0.5 to 1 hour, and gradually adjusting the system vacuum degree to -0.098MPa in the condition of keeping the temperature until the reaction is over. The method has reasonable process route, good selectivity, high product yield ...

Pulse Diagnosis Instrument

The invention provides a device for sphygmus diagnosis, including a positioning component independently fixed around one's wrist, said positioning component has a visible positioning window. Said sphygmus diagnosis device also has a sensor component which is installed in the positioning component. After assembly the sensor probe of said sensor component is located inside said positioning window. The invention has the following advantages: 1. The determinate position of pulse is accurate. 2. Avoiding the measuring position's deviation caused by the moving of the wrist. 3. Ensuring the stability when positioning component fixed around the wrist. 4. The wrist-pillow can rotate freely, which is convenient to achieve the switch between left and right hand for acquisition for pulse. 1. A device for sphygmus diagnosis , comprising a positioning component independently fixable around the patient's wrist , said positioning component including a visible positioning window.2. The device as set forth in claim 1 , wherein said diagnosis device also has a sensor component which is removably insertable in the positioning component claim 1 , which after assembling the sensor probe of said sensor component is located inside the positioning window.3. The device as set forth in claim 2 , wherein around said positioning window there are positioning marks for directing to the position of pulse.4. The device as set forth in claim 3 , wherein said positioning marks are respectively positioned in the middle of each side of said positioning window.5. The device as set forth in claim 2 , wherein said sensor has a elastic snap-fit claim 2 , said positioning component has a cooperating slot claim 2 , and when assembling claim 2 , the elastic snap-fit of said sensor component is stuck inside the slot of said positioning component.6. The device as set forth in claim 2 , wherein the part of said sensor component fitting one's wrist is a concave arc.7. The device as set forth in claim 6 , wherein ...

Biaryl amide compounds as kinase inhibitors

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

Vehicle accident aviation warning, law enforcement and evidence storage method based on privacy compound block chain system

The invention discloses a vehicle accident aviation warning, law enforcement and evidence storage method based on a privacy compound block chain system. The method comprises the following steps: constructing the privacy compound block chain system for vehicle accident block chain law enforcement and evidence storage; after a vehicle traffic accident occurs, a vehicle traffic accident party gives an alarm, and a navigation warning law enforcement agency coordinates navigation warning law enforcement equipment to arrive at a vehicle traffic accident place, collects accident information in an omnibearing manner, and synchronously uploads the accident information to a privacy compound block chain system; the aviation warning law enforcement agency and the insurance agency intervene in an accident processing process through the privacy compound block chain system, give a processing result according to reference suggestions of the federal learning training model, and store the whole process of ...

METHOD AND SYSTEM FOR CONSTRUCTING XML QUERY TO SCHEMA VARIABLE XML DOCUMENTS

An XML querying method and system for constructing an XQuery/XPath query to a schema variable XML document. The method includes: receiving the query from a client computer; generating a tree structure; and generating, by query rewriting, an XQuery/XPath for the XML document based on the tree structure and configurable query constraints. The system includes: a tree structure generating unit for generating a tree structure; and a query writing unit for generating an XQuery/XPath query for the XML document based on the tree structure and configurable query constraints.

System and Method For Automatically Refining Ontology Within Specific Context

The present invention provides a system and method for automatically refining ontology within a specific context. The system comprises: a rich context extractor for discovering a semantics relationship conflict existing between an original ontology schema and application data; and an ontology schema and mapping refiner for refining the original ontology schema based on the semantics relationship conflict discovered by the rich context extractor, and creating a new mapping between the refined ontology schema and a data schema of the application data. According to the invention, users can save a lot of work of manual refinement, since the ontology schema is automatically refined based on contexts in the application data.

Dispersion-induced ultra-sensitive gas sensor based on micro-nanofiber and detection method

The invention discloses a dispersion-induced ultra-sensitive gas sensor based on a micro-nanofiber and a detection method, and belongs to the technical field of light interference metering devices, the dispersion-induced ultra-sensitive gas sensor comprises a first laser, a Mach-Zehnder interferometer, a second laser and a signal processing system, the second laser is used for generating pump light, the Mach-Zehnder interferometer comprises an optical fiber coupler, a micro-nano optical fiber and an optical fiber collimator, and the micro-nano optical fiber is located on a gas sensing arm of the Mach-Zehnder interferometer. According to the invention, the single-mode micro-nano optical fiber is used for transmitting the probe light, the evanescent field is large when the pump light is propagated in the micro-nano optical fiber, the photothermal effect is strong, and the sensor has excellent sensing transient response; by adjusting the distance between the end faces of the optical fiber ...

Prediction model of tumor gene for driving malignant pulmonary nodule lymph node metastasis by changing immune microenvironment

The invention relates to the field of biological detection, in particular to a prediction model of malignant pulmonary nodule lymph node metastasis driven by tumor genes by changing an immune microenvironment. The invention provides a detection marker. The detection marker comprises CYP2D6, NOTCH2, RASGEF1A, MLH1, SDHC, BAP1, SLC34A2, CYP2A7, APC, PRKDC, ATF1, PDE11A, EPHA2, THADA, SETD2, ERBB4, RHBDF2, EGFR (epidermal growth factor receptor), KRAS, BRAF, TP53, RB1, RBM10, STK11 or SMARCA4. The model provided by the invention is simple, intuitive and easy to popularize, can effectively help a clinician to predict lymph node metastasis before an operation, and provides transformation research evidence for lymph node cleaning operation and perioperative treatment, so that theoretical guidance is provided for monitoring and treatment of a patient.

File classification management system and method used in operating systems

The invention provides a file classification management system and method used in operating systems for managing the files by categories. Each of the physically stored files is mapped into one or more logical categories based on the contents of the file. And a desktop files resource manager presents the files by categories organized in a tree structure such that the user can directly find desired files via categories by using the present invention. The invention significantly improves the function of the file system and makes the file management interface more friendly.

Traditional Chinese medicine inspection detection device

The invention discloses a traditional Chinese medicine inspection detection device which comprises an outer shell, a light source and a shooting structure, wherein the light source and the shooting structure are located in the outer shell, a light conducting assembly is arranged in the outer shell, and the light conducting assembly comprises at least one light conducting layer; the light source is arranged on the light conducting layer or a side section thereof, and the light source forms a surface light source through the diffuse reflection of the light conducting assembly. Because the lightconducting assembly is used for conducting light rays in the invention and the point light source is converted into the surface light source, a soft, stable and uniform shooting environment similar to natural light is formed inside the detection device.

Dirty oil blending combustion method and device

The invention relates to the technical field of generator set sump oil treatment, in particular to a sump oil blending combustion method and device. The method comprises the steps that sump oil is collected through an oil drum and subjected to standing precipitation; the surface layer of the sump oil is extracted through the extraction device, and the extracted sump oil is conveyed into the oil gun to be atomized and mixed with fuel oil to be combusted; and installing a recirculation pipeline between the extraction device and the oil drum. According to the sump oil blending combustion method and device, sump oil is collected in a unified mode and then subjected to static settlement, the sump oil pump is used for pumping and feeding the sump oil into the oil gun for atomization and combustion, the filtering mechanism filters the oil inlet of the sump oil pump, and sustainable pumping combustion of the sump oil is achieved.

Biaryl amide compounds as kinase inhibitors

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

Method and device for creating eye template as well as method and device for detecting eye state

The invention provides a method and a device for creating an eye template as well as a method and a device for detecting an eye state. The method for creating the eye template comprises the following steps: extracting an eye region in a facial image; obtaining a radially symmetrical transformation result of each pixel in the eye region by a fast radially symmetrical transformation algorithm; determining the position of the pixel with a maximal value of the radially symmetrical transformation result as a pupil position; selecting a region containing the pupil position in the facial image in which the pupil position is positioned as the eye template. The method for creating the eye template is capable of accurately positioning the pupil position, so that the created eye template is accurate and reliable. The method for detecting the eye state comprises the following steps: obtaining the eye template by use of the method for creating the eye template; searching a to-be-detected region; determining ...

Method for making non-volatile memory by using MIM capacitor structure

The invention discloses a method for making a non-volatile memory by using an MIM capacitor structure of a standard CMOS process and belongs to the technical field of ultra-large scale integrated circuits. The method comprises the following steps of: making the MIM capacitor structure based on the standard CMOS process; and doping the medium layer of the MIM capacitor to form a variable-resistance material layer so as to obtain a variable-resistance memory with the MIM structure. The method is completely compatible with the standard CMOS process, can make the variable-resistance memory through layout design without changing the CMOS process or adding any complex process, and reduces the cost.

Method of testing computer memory

The present invention relates to a method of testing computer memory, comprising: use a basic input and output system (BIOS) to obtain the information of each memory and display them on an operation interface; select the memory to be tested through the operation interface; test the memory in accordance with the selection; and output the testing result to the operation interface according to the testing result of the memory to be tested.

Method and System of Annotation for Electronic Documents

The present invention provides a method of annotation for electronic document, a method for creating, modifying and browsing an annotation in an electronic document, and an apparatus and system for editing, browsing annotations in electronic document. The method of annotation for electronic document includes: storing annotation contents for one or more electronic documents into a shared dictionary; and when a reader browses an electronic document, providing the reader with annotations for the electronic document based on the shared dictionary.

Method and system for constructing XML query to schema variable XML documents

An XML querying method and system for constructing an XQuery/XPath query to a schema variable XML document. The method includes: receiving the query from a client computer; generating a tree structure; and generating, by query rewriting, an XQuery/XPath for the XML document based on the tree structure and configurable query constraints. The system includes: a tree structure generating unit for generating a tree structure; and a query writing unit for generating an XQuery/XPath query for the XML document based on the tree structure and configurable query constraints.

Universal integrated navigation system test software architecture

The invention discloses a general integrated navigation system test software architecture, which comprises a protocol configuration module, a data acquisition module, a data analysis module, a data storage module and a data processing module, and software under the architecture can be operated in other equipment with an operating system and a display screen, such as an industrial personal computer, a notebook computer, a PC (Personal Computer) and the like. According to the invention, the acquired test data sent by the integrated navigation equipment can be received through the interface, processed and displayed on the display screen, meanwhile, the test data is stored in a background specified path, and the stored data file can be analyzed as required after the test is completed, so that developers can conveniently test different integrated navigation products by changing the configuration, and the test efficiency is improved. The data transmitted by the integrated navigation system is ...

Data updating method and device, processor and electronic equipment

The invention discloses a data updating method and device, a processor and electronic equipment. The method relates to the field of financial science and technology, and comprises the steps that a data acquisition request from a target terminal is acquired, and the data acquisition request is used for requesting access data from a target database; determining a data access interface corresponding to the data acquisition request; and based on the access parameter of the data access interface, sending access data in the target database to the target terminal, the access data being used for updating data stored in the target terminal. Through the method and the device, the technical problem of low data processing efficiency of cross-department collaboration in related technologies is solved.

Triazole compounds as KSP inhibitors

The present invention provides triazole compounds of Formula I: as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula I.

Data analyzing method, apparatus and a method for supporting data analysis

A data analyzing method, apparatus, and a method for supporting data analysis includes creating or storing a semantic entity repository, wherein the semantic entity repository includes a structured entity set of entities and properties thereof, reference ranges describing the possible values of the properties, and the mappings between the entities and properties and a data structure of a data warehouse. When aggregating data, the entities, properties, and/or property values to be analyzed are selected from the semantic entity repository, and how to calculate at least one measure is defined. The data corresponding to the selected entities, properties, and property values are loaded from the data warehouse according to the mappings, and the at least one measure as defined is calculated.

Optical cable

The invention discloses an optical cable, comprising a butterfly optical cable and a water blocking tape, wherein the two sides of the butterfly optical cable are provided with reinforcements, a sheath is sheathed outside the reinforcements, and the water blocking tape is wound on the butterfly optical cable and the reinforcements. In the optical cable of the invention, the reinforcements are arranged at the two sides of the butterfly optical cable, so that the hardness of the optical cable is improved and the tensile strength is improved, and meanwhile the water blocking tape is wound on the butterfly optical cable and the reinforcements, and the water blocking tape can be expanded and filled in the whole sheath when water enters as the optical cable is damaged, so that water can no longer enter the cable, the effects of waterproofing and water blocking are realized, the service life is prolonged, and the using effect is improved.

Communication optical cable wire

The invention discloses a communication optical cable wire, which comprises a butterfly optical cable. A reinforcing member is arranged outside the butterfly optical cable, and a protective casing is sleeved outside the reinforcing member. As a reinforcing member is arranged outside the butterfly optical cable, the hardness of the optical cable is enhanced, the tensile strength is increased, the service life is prolonged and the use effect is improved.

Emission reduction method for promoting reaction of coke and carbon dioxide through inductance

The invention relates to the technical field of energy conservation and emission reduction, in particular to an emission reduction method for promoting reaction of coke and carbon dioxide through inductance. The invention provides an emission reduction method for promoting reaction of coke and carbon dioxide by inductance, which comprises the following steps: in a carbon dioxide atmosphere, graphitized coke is self-heated in an electromagnetic induction field to obtain carbon monoxide. According to the invention, free electrons in the graphitized coke are utilized to generate eddy current in an alternating magnetic field, and the eddy current generates heat due to resistance of the coke. As the chemical reaction is essentially electron migration, the electron eddy current in the coke certainly accelerates the electron movement rate of the coke, promotes the reaction between the coke and carbon dioxide, and accelerates the generation of CO; meanwhile, CO is an important platform chemical ...

Optical sampling broadband radio frequency signal processing method and device for satellite-borne integrated application

The invention discloses an optical sampling broadband radio frequency signal processing method and device for satellite-borne integrated application, and belongs to the field of optical sampling broadband radio frequency signal processing, and the method comprises the steps: dividing a laser pulse generated by a femtosecond pulse laser into two parts which are respectively used for collecting a synchronous clock signal of an ADC (Analog to Digital Converter) and an optical carrier signal for bearing radio frequency information, the optical carrier loaded with the radio frequency signal is divided into two paths to be output, the two paths are sequentially connected into a polarization controller and a polarization beam splitter and are respectively processed to obtain an I-path signal and a Q-path signal, and the I-path signal and the Q-path signal are respectively subjected to photoelectric detection of a balance detector, are digitalized by a data acquisition card ADC and then are input ...

Personalized classification for browsing documents

The present invention provides document classification methods, apparatus and systems for browsing documents in the Internet. The method includes the steps of: creating a plurality of categories on the server side, assigning the documents to be browsed by the user to the corresponding categories, and managing said plurality of categories in a flat structure; and on the client side, selecting the required categories from the plurality of categories to create a personalized classification structure. The cost of calculating and storing can be greatly reduced by utilizing the system and method according to the present invention.

Method and device for generating browsing paths for data and method for browsing data

The invention provides a method of generating browsing routes for data, a method of browsing data, a device of generating browsing routes for data and a computer program product. According to one facet of the invention, a method of generating browsing routes for data which is provided includes the following steps: generating a plurality of candidate browsing routes according to a data model whichdescribe the structure of the data; as to every route of the candidate browsing routes, calculating the importance of the browsing routes according to part of the data which is corresponding to the browsing routes; choosing at least one route of the candidate browsing routes according to the importance of the calculating.

Heteroaryl compounds and their uses

The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.

Method and system for determining node to be materialized

A dependency graph of rule predicates without strongly connected sub-graph is obtained. The dependency graph indicates the dependency among the rule predicates. An update frequency of node in the dependency graph is calculated, and a query frequency of node in the dependency graph is also calculated. Furthermore, a runtime query cost value and a materialization cost value of the node are calculated based on the query frequency and update frequency. Node to be materialized are determined based on the runtime query cost value and the materialization cost value. A rule predicate corresponding to the node to be materialized is the rule predicate to be materialized. In at least some instances, an exemplary technical effect is that the return time of result of runtime query is saved and the affect by the data update is reduced when a query is performed in relation data reasoning system constructed with rule predicates.

Resistive random access memory and production method thereof

The invention discloses a resistive random access memory and a production method thereof, and belongs to the technical field of CMOS (complementary metal oxide semiconductor) ultra large scale integrated circuits (ULSI). The resistive random access memory comprises a substrate. An insulating layer and a bottom electrode are arranged on the substrate. An isolation layer and a first-layer resistive film are arranged on the bottom electrode. A groove-shaped device area is formed in the isolation layer. The U-shaped first-layer resistive film is deposited in a groove of the isolation layer. A vacuum isolation layer is arranged between the outer side wall of the first-layer resistive film and the inner side wall of the groove. A second-layer resistive film covers the first-layer resistive film and the isolation layer to seal the vacuum isolation layer. A top electrode is arranged on the second-layer resistive film. The resistive random access memory and the production method thereof have the ...

Stomach self-anchoring biopsy magnetic control capsule robot based on flexible hinge

The invention discloses a stomach self-anchoring biopsy magnetic control capsule robot based on a flexible hinge. Comprising an image module located at the head of the capsule robot, a biopsy module coaxially and fixedly connected with the image module, a rotation decoupling module used for controlling the capsule robot to move and a hinge control module used for anchoring the capsule robot. A flexible hinge is adopted to enable the capsule to have a self-anchoring function, a radial magnetized magnet is installed in the capsule to drive the capsule to roll and release the hinge, and meanwhile an axial magnetized magnet is installed to control a biopsy needle to stretch out for sampling. The positioning accuracy of pathological tissues and the stability of biopsy sampling are improved; the clockwise and anticlockwise movement of the radial magnetized magnet is decoupled through screw-thread fit and gear fit, so that the capsule can be driven to roll, the hinge can be controlled to be released ...

Path-based ranking of unvisited web pages

Path-based ranking of unvisited Web pages for WWW crawling is provided, via identifying all the paths beginning with a seed URL and leading to visited relevant web pages as good-path set, and for each unvisited web page, identifying the paths beginning from the seed URL leading to it as partial-path set; classifying all the visited web pages and labeling each web Page with the labels of a class or classes it belongs to; training a statistic model for generalizing the common patterns among all ones of good-path set; and evaluating the partial-path set with the statistic model and ranking the unvisited web pages with the evaluation results.

Method and system for distributing and updating heterogeneous resources

Methods, systems and apparatus for distributing and updating resources. An example method comprising the steps of: a resource producer registering a resource and a resource plug-in with a first server, and submitting a resource patch thereto when a resource update occurs; a second server replicating the resource, the resource plug-in and the resource patch from the first server, and a resource consumer downloading the resource, the resource plug-in and the resource patch from the second server; and updating the resource at the resource consumer side by executing the resource plug-in to apply the resource patch on the resource, and obtaining an updated resource version. The method and system of the present invention will greatly save network bandwidth in a large scale progressive resource distribution and make the design more flexible and extensible.

Hydraulic suspension structure of engine

The engine hydraulic suspension structure comprises a shell, a rubber main spring and a partition plate, the shell is provided with a sealing cavity, a hydraulic medium is arranged in the sealing cavity, the rubber main spring and the partition plate are vertically and synchronously arranged in the sealing cavity in a sliding mode, and the top of the rubber main spring extends upwards to form a transmission rod penetrating through the shell; a limiting piece used for limiting the rubber main spring is arranged in the shell, the partition plate divides the sealing cavity into an upper cavity and a lower cavity, the rubber main spring is located in the upper cavity, and therefore the upper one-way filtering assembly and the lower one-way filtering assembly can filter and remove impurities of hydraulic media flowing back and forth between the upper liquid chamber and the lower liquid chamber. The hydraulic medium can flow between the upper liquid hole and the lower liquid hole more smoothly ...

METHOD AND SYSTEM FOR PROVIDING NATIVE-LANGUAGE INQUIRY SERVICE

PURPOSE: A method and a system for providing native-language inquiry service are provided to enable a user to search by using native language. CONSTITUTION: A method for providing native language query service for Internet users by using a plurality of search engines in the Internet, each search engine having a respective dedicated language, adapted for receiving query requests containing query words of the dedicated language and returning query results in relation to the query words, the method characterized by comprising steps of receiving at a site an original query request from one of the Internet users, the original query request containing query words of native language of the user, selecting a suitable search engine from the plurality of search engines, translating the query words of native language into query words of dedicated language of the selected search engine, constructing a new query request directing to the selected search engine based on the original query request and ...

Tension control device for winding of glass fiber reinforced plastic anchor rod

The invention relates to a tension control device for winding of a glass fiber reinforced plastic anchor rod. The tension control device comprises a winding motor, a left paying-off motor and a right paying-off motor, which are all arranged on a rack, a main driving axle system arranged on the rack, a left paying-off axle, a right paying-off axle, a winding motor, a left paying-off axle sprocket wheel and a right paying-off axle sprocket wheel, wherein a turntable is fixed at the right end of the main driving axle system, the left paying-off axle and the right paying-off axle are symmetrically arranged on the turntable, a winding output sprocket wheel, a left paying-off output sprocket wheel and a right paying-off output sprocket wheel are arranged on the output shafts of the left paying-off motor and the right paying-off motor respectively, the left paying-off axle sprocket wheel and the right paying-off axle sprocket wheel are arranged on the left paying-off axle and the right paying-off ...

Refractive index sensor based on grating-prism system and measuring method thereof

The invention discloses a refractive index sensor based on a grating-prism system and a measuring method of the refractive index sensor, and belongs to the technical field of light interference metrology, the refractive index sensor comprises parallel light, a plane grating, a sample pool, a convergence part and a spectral analysis system which are arranged in sequence, a triangular prism and a sample to be measured are arranged in the sample pool, the parallel light is transmitted through the plane grating, and the plane grating is transmitted through the spectral analysis system. The plane grating divides the parallel light into a plurality of sub-light beams, and then the sub-light beams are converged by the convergence component and reach the spectral analysis system for refractive index measurement. Incident parallel light is periodically shielded by using a plane grating, the parallel light is divided into sub-beams, each level of diffraction light of each sub-beam is regarded as ...

BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

TRIAZOLE COMPOUNDS AS KSP INHIBITORS

The present invention provides triazole compounds of Formula I: as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula I.

Cultivating and preparing method of I-type dengue virus KMB17 cell adapted strain

The invention discloses an I-type dengue virus KMB17 cell adapted strain and a preparation method thereof. A popular I-type dengue virus strain can be adapted onto a human embryo lung cell KMB17 for growing to obtain the cell adapted strain which stably goes down to posterity on the KMB17 cell and is strong in virus replication capacity, and the purified adapted strain with high purity is obtained by virtue of a method of purifying bacteriophage plaque by many times. According to a series of identifications on the virus, the I-type dengue virus keeps good antigenicity and basic biological characteristics of the original virus strain. According to the invention, the I-type dengue virus KMB17 cell adapted strain can carry out I-type dengue virus amplification by taking the human embryo lung cell KMB17 as substrate, breaks through limitation of an I-type dengue virus host cell, and lays a foundation for quickening developing a novel idea for researching a dengue virus prophylactic vaccine, ...

Method for exchanging heat of cooling water in graphite heat exchange block in hydrogen chloride synthesis furnace with high efficiency

The invention discloses a method for exchanging heat of cooling water in graphite heat exchange block in a hydrogen chloride synthesis furnace with high efficiency. The method is characterized in that an cooling water inlet is respectively arranged at left and right sides of the graphite heat exchange block, a binary channel arc-shaped baffling ring is arranged outside a transverse aperture of the graphite heat exchange block, the cooling water in the transverse aperture of the graphite heat exchange block is introduced from the left and right water inlets, and is subjected to binary channel convection interlace flowing from down to up in the transverse aperture of the graphite heat exchange block through the binary channel arc-shaped baffling ring, heat exchange efficiency of the high temperature hydrogen chloride gas of the graphite heat exchange block in the hydrogen chloride synthesis furnace and the cooling water, the method enhances the economic benefit of the enterprise through energy ...

Expandable structure appearance plane scanning unit and device

The invention relates to an expandable structure appearance plane scanning unit and device. The plane scanning unit comprises a frame-type skeleton, a walking assembly, an imaging assembly and a background module, the frame-type skeleton is provided with a rapid connection original part so as to realize free expansion connection of the frame-type skeleton, and the frame-type skeleton comprises at least one lattice; the walking assembly is arranged below the frame type framework; the imaging assembly comprises a plurality of imaging units, and the background module comprises an equipment control unit, a data transmission unit and a data processing unit. Compared with the prior art, the quick connecting original part is arranged in a matched mode, so that free expansion connection of the frame type framework is achieved, the inspection requirement for the appearance plane of a large-scale structure with a specific area is met, standard imaging and large-area scanning with fixed parameters ...

Embedded integrated navigation software architecture and design method thereof

The invention provides an embedded integrated navigation software architecture and a design method thereof, software is decomposed into a hardware adaptation drive part, an equipment management part, a logic management part and a core algorithm part by decoupling a system architecture part, and embedded integrated navigation software is constructed based on a non-embedded operating system. According to the embedded integrated navigation software architecture and the design method thereof, under the condition of limited resources, aiming at the complexity of a multi-frequency information source and an algorithm strategy, the algorithm and each process scheduling strategy are set through life cycle analysis of each task and time sequence analysis of a periodic task. According to the method, the coupling property of each part of software is reduced, the reusability, portability and robustness are improved, the development and later maintenance efficiency is improved, the response can be fast ...

Aminoheteroaryl benzamides as kinase inhibitors

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

METHOD AND SYSTEM FOR DETECTING CHEST X-RAY THORACIC DISEASES UTILIZING MULTI-VIEW MULTI-SCALE LEARNING

Embodiments of the disclosure provide systems and methods for biomedical image analysis. A method may include receiving a plurality of unannotated biomedical images, including a first image and a second image. The method may also include determining that the first image is in a first view and the second image is in a second view. The method may further include assigning the first image to a first processing path for the first orientation. The method may additionally include assigning the second image to a second processing path for the second view. The method may also include processing the first image in the first processing path in parallel with processing the second image in the second processing path. The first path may share processing parameters with the second path. The method may further include providing a diagnostic output based on the processing of the first image and the second image. 1. A system for biomedical image analysis , comprising:a communication interface configured to receive a plurality of unannotated biomedical images, the biomedical images including a first image and a second image being acquired in a pair by an image acquisition device; and determine that the first image is in a first view and the second image is in a second view;', 'assign the first image of the plurality of unannotated biomedical images to a first processing path comprising a first set of processing modules designed for the first orientation;', 'assign the second image of the plurality of unannotated biomedical images to a second processing path comprising a second set of processing modules designed for the second view;', 'process the first image in the first processing path in parallel with processing the second image in the second processing path, wherein the first set of processing modules share processing parameters with the second set of processing modules; and', 'provide a diagnostic output based on the processing of the first image and the second image., 'at least ...

AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS

The present invention provides a compound of Formula (I) or a salt thereof; 1. A compound which is 4-(3-amino-6-((1S ,3S ,4S)-3-fluoro-4-hydroxycyclohexyl)pyrazin-2-yl)-N—((S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl)-2-fluorobenzamide in hydrochloride salt form.3. A pharmaceutical composition comprising 4-(3-amino-6-((1S ,3S ,4S)-3-fluoro-4-hydroxycyclohexyl)pyrazin-2-yl)-N—((S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl)-2-fluorobenzamide , or a pharmaceutically acceptable salt thereof , and one or more co-therapeutic agents selected from the group consisting of inhibitors of B-RAF , C-RAF , MEK , CDK4/6 , SHP-2 , HDAC , EGFR , MET , mTOR , PI3K and AKT.4. The composition of wherein the co-therapeutic agent is a B-RAF inhibitor or a C-Raf inhibitor.5. The composition of wherein the co-therapeutic agent is selected from emurafinib claim 2 , debrafinib claim 2 , LGX818 claim 2 , trametinib claim 2 , MEK162 claim 2 , LEE011 claim 2 , PD-0332991 claim 2 , panobinostat claim 2 , verinostat claim 2 , romidepsin claim 2 , cetuximab claim 2 , gefitinib claim 2 , erlotinib claim 2 , lapatinib claim 2 , panitumumab claim 2 , vandetanib claim 2 , INC280 claim 2 , everolimus claim 2 , simolimus claim 2 , BKM120 claim 2 , BYL719 and CLR457.6. A method of treating cancer claim 2 , in a patient in need thereof claim 2 , comprising administering a therapeutically effective amount of a composition of ; wherein the cancer is selected from ovarian claim 2 , NSCLC claim 2 , melanoma and solid tumors. This application is a continuation of U.S. patent application Ser. No. 15/672,568, filed Aug. 9, 2017, which is a continuation of U.S. patent application Ser. No. 14/964,057, filed Dec. 9, 2015, which is a divisional of U.S. patent application Ser. No. 14/527,328, filed Oct. 29, 2014, which claims priority under 35 U.S.C. § 119 to International Application No. PCT/CN2014/088409, filed Oct. 11, 2014, and claims benefit of U.S. Provisional Application No. 61/898,761, filed Nov. ...

PREFETCHING RDF TRIPLE DATA

Query requests for RDF triples are obtained, wherein the query request(s) contain(s) at least one triple pattern; for each triple pattern, the corresponding elementary pattern is determined, and each triple pattern is converted to a weighted elementary pattern. The occurrence frequency of each elementary pattern is computed based on the weighted elementary patterns; at least one elementary pattern is chosen at least according to the occurrence frequency; and the RDF triples corresponding to the chosen at least elementary pattern are prefetched into the buffer. The corresponding apparatus is also provided. With the above method and apparatus, the frequently accessed RDF triples can be determined and prefetched into the buffer, which improves the query efficiency. 1. A method for processing RDF triples , comprising:obtaining query requests for RDF triples, wherein said query requests each contain at least one triple pattern;determining elementary patterns corresponding to said triple patterns;performing weighting with respect to said corresponding elementary patterns to weighted elementary patterns;computing occurrence frequency of said elementary patterns based on the weighted elementary patterns; andprefetching those of the RDF triples corresponding to said elementary patterns into a buffer if the occurrence frequency of said elementary patterns meets at least one predetermined condition.2. The method of claim 1 , wherein obtaining the query requests for the RDF triples comprises reading query request records from a query log.3. The method of claim 1 , wherein said elementary patterns are in a form of .4. The method of claim 1 , wherein said weighting comprises setting the weight of a certain triple pattern with respect to a corresponding elementary pattern as a constant.5. The method of claim 1 , wherein said weighting comprises determining weight of said at least one triple pattern with respect to a corresponding one of said elementary patterns by ...

OBTAINING HIERARCHICAL INFORMATION OF PLANAR DATA

The invention provides a method and apparatus for obtaining hierarchical information of planar data. The method comprises mapping at least one data item from a same data set in the planar data to at least one node in a tree structure formed by a structured terminology system. The method also comprises obtaining at least one sub tree structure in the tree structure, each of the at least one sub tree structure taking the at least one node as all of its leaf node. The method also comprises selecting a target tree structure from the at least one sub tree structure and obtaining hierarchical information in the target tree structure. An apparatus corresponding to the above method is also provided. With the above method and apparatus, hierarchical information of data items may be obtained from planar organized data to facilitate subsequent and further analysis and management. 1. A method for obtaining hierarchical information of planar data , the method comprising:mapping at least one data item from a same data set in the planar data to at least one node in a full tree structure formed by a structured terminology system;obtaining at least one sub tree structure in the full tree structure, each of the at least one sub tree structure taking the at least one node as all leaf nodes of the sub tree structure;selecting a target tree structure from the at least one sub tree structure; andobtaining hierarchical information in the target tree structure.2. The method according to claim 1 , wherein the step of mapping at least one data item to at least one node comprises:mapping the at least one data item to at least one terminology in the structured terminology system; andmapping the at least one terminology to the at least one node in the full tree structure.3. The method according to claim 1 , wherein the step of obtaining at least one sub tree structure in the full tree structure comprises:traversing upward starting from each of the at least one node as a leaf node till a root ...

METHOD FOR ACHIEVING FOUR-BIT STORAGE USING FLASH MEMORY HAVING SPLITTING TRENCH GATE

The present invention discloses a method for achieving four-bit storage by using a flash memory having a splitting trench gate. The flash memory with the splitting trench gate is disclosed in a Chinese patent No. 200710105964.2. At one side that each of two trenches is contacted with a channel, a programming for electrons is achieved by using a channel hot electron injection method; and at the other side that each of the two trenches is contacted with a source or a drain, a programming for electrons is achieved by using an FN injection method, so that a function of a four-bit storage of the device is achieved by changing a programming mode. Thus, a performance of the device is improved while a storage density is greatly increased. 1. A method for achieving four-bit storage using a flash memory having a splitting trench gate , wherein the flash memory having the splitting trench gate is based on a planar structure; a tunneling oxide layer , a silicon nitride trap layer , a blocking oxide layer and a control gate are sequentially disposed over a channel; two trenches having an identical structure each are disposed between a source and the channel and between a drain and the channel , respectively; one side of each of the trenches is contacted with the channel , and the other side of each of the trenches is contacted with the source or the drain; the splitting trench gate structure is formed in the channel; the channel is formed by a planar channel in middle and two non-planar channels corresponding to the trenches; the trenches and the channel are completely covered by the control gate and a gate stack structure comprising the tunneling oxide layer , the silicon nitride trap layer , the blocking oxide layer; and the control gate has two protruding portions corresponding to the trenches , the method being characterized in that , at the one side that each of the two trenches is contacted with the channel , a programming for electrons is achieved by using a channel hot ...

MULTILEVEL RESISTIVE MEMORY HAVING LARGE STORAGE CAPACITY

The present invention discloses a multilevel resistive memory having large storage capacity, which belongs to a field of a fabrication technology of a resistive memory. The resistive memory includes an top electrode and a bottom electrode, and a combination of a plurality of switching layers and defective layers interposed between the top electrode and the bottom electrode, wherein, the top electrode and the bottom electrode are respectively contacted with a switching layer (a film such as TaO, TiO, HfO), and the defective layers (metal film such as Ti, Au, Ag) are interposed between the switching layers. By using the present invention, a storage capacity of a resistive memory can be increased. 1. A multilevel resistive memory having large storage capacity comprising an top electrode and a bottom electrode , wherein a combination of a plurality of switching layers and defective layers is interposed between the top electrode and the bottom electrode , wherein , the top electrode and the bottom electrode are respectively contacted with a switching layer , and the defective layers are interposed between the switching layers.2. The multilevel resistive memory having large storage capacity according to claim 1 , wherein the top electrode and the bottom electrode are W claim 1 , Al claim 1 , Pt or TiN metal films with a thickness between 150 nm and 500 nm.3. The multilevel resistive memory having large storage capacity according to claim 1 , wherein the switching layers are TaO claim 1 , TiOor HfOfilms with a thickness between 10 nm and 80 nm.4. The multilevel resistive memory having large storage capacity according to claim 1 , wherein the defective layers are Ti claim 1 , Au or Ag metal films with a thickness between 2 nm and 50 nm. The present application claims priority to Chinese application number NO. 201110274869.1, filed on Sep. 16, 2011, which is incorporated herein by reference.Embodiments of the present invention relate to a method capable of increasing storage ...

DATA PROCESSING

A method and apparatus for data processing. The method calculates correlations between a plurality of attributes in a dataset. The attributes are factors involved in transaction processing. The method generates a relationship graph by using the plurality of attributes and the correlations between the plurality of attributes; and extracts a sub-graph from the relationship graph to represent a hypothesis. The hypothesis describes the impacts of the factors on the transaction processing. Also provided is an apparatus for implementing the above data processing method. 1. A method for data processing , comprising:calculating correlations between a plurality of attributes in a dataset, the attributes being factors involved in transaction processing;generating a relationship graph by using the plurality of attributes and the correlations between the plurality of attributes; andextracting a sub-graph from the relationship graph to represent a hypothesis, wherein the hypothesis describes impacts of the factors on the transaction processing.2. The method according to claim 1 , wherein the attributes further comprise:a performance indicator, an intervention, and a confounder; anddata types of the attributes comprising at least one of scale, nominal, and ordinal.3. The method according to claim 2 , wherein the calculating correlations between a plurality of attributes in a dataset further comprises:calculating a correlation between an attribute with a classification of performance indicator and an attribute with a classification of intervention; andcalculating a correlation between an attribute with a classification of performance indicator and an attribute with a classification of confounder.4. The method according to claim 1 , wherein the calculating correlations between plurality of attributes in a dataset further comprises:a first and a second attribute among the plurality of attributes, which as being used to calculate the correlations based on a value of the first ...

HETEROARYL COMPOUNDS AND THEIR USES

The present invention provides a compound of formula (I): 2. The method of claim 1 , wherein:{'sub': '8', 'Ris Cl.'}3. The method of claim 1 , wherein:{'sub': 1', '16, 'Ris X—R;'}{'sub': '1-2', 'X is a bond, or Calkyl;'}{'sub': 16', '1-2', '4-6, 'Ris selected from the group consisting of C-alkyl, Ccycloalkyl, heterocycloalkyl, phenyl, and heteroaryl;'}{'sub': 16', '1-3', '3-6', '1-2', '22', '12', '1-2', '12', '12', '22', '12', '19', '22', '19', '13', '14', '15', '2', '12', '17', '18', '22', '17', '18', '15', '19', '22', '15', '19', '15', '2, 'wherein Ris substituted with one to three groups independently selected from halogen, hydrogen, Calkyl, Cbranched alkyl, OH, Calkoxy, R—OR, S(O)R, C(O)OR, R—C(O)OR, C(O)R, R—OC(O)R, C(O)NRR, NRS(O)R, NRR, R—NRR, NRC(O)R, R—NRC(O)R, and NRC(O)OCHPh.'}5. The method of wherein:{'sub': 3', '2, 'Ris selected from H, methyl, cyano, chloro, CONH, amino, cyclopropyl, ethyl, and fluoro;'}{'sub': '4', 'Ris selected from halogen, methyl, hydrogen, and halo-methyl;'}{'sub': '6', 'Ris H;'}{'sub': 7', '2', '3, 'Ris selected from H, COOH, Cl, F, CONH, CN, and CF;'}{'sub': '8', 'Ris Cl;'}{'sub': 17', '18', '1-3', '1-4', '3-6', '22', '12', '22', '2', '12', '22', '15', '2', '12', '17', '18', '20', '21, 'Rand Rare each, independently, selected from the group consisting of hydrogen, Calkyl, Chaloalkyl, Cbranched alkyl, R—OR, R—S(O)R, R—NRS(O)R, heterocycloalkyl or heteroaryl; alternatively, Rand Ralong with the nitrogen atom to which they are attached to can be taken together to form a four to six membered heterocyclic ring wherein said ring carbon atoms are optionally substituted with R, and the ring nitrogen atoms are optionally substituted with R;'}{'sub': 19', '1-3, 'Ris selected from C-alkyl, optionally substituted heterocycloalkyl, optionally substituted aryl or optionally substituted heteroaryl;'}{'sub': 20', '1-3, 'Rrepresents the group Calkyl; and'}{'sub': 22', '1-4', '3-6, 'Ris selection from the group consisting of Calkyl, and Cbranched ...

METHOD FOR FABRICATING RESISTIVE MEMORY DEVICE

The present invention discloses a method for fabricating a resistive memory, including: fabricating a bottom electrode over a substrate; partially oxidizing a metal of the bottom electrode through dry-oxygen oxidation or wet-oxygen oxidation to form a metal oxide with a thickness of 3 nm to 50 nm as a resistive material layer; finally fabricating a top electrode over the resistive material layer. The present invention omits a step of depositing a resistive material layer in a conventional method, so as to greatly reduce the process complexity. Meanwhile, a self alignment between the resistive material layer and the bottom electrode can be realized. A full isolation between devices may be ensured so as to obviate the parasite effects occurred in the conventional process methods. Meanwhile, the actual area and designed area of the device are ensured to be consistent. 1. A method for fabricating a resistive memory , comprising:1) fabricating a bottom electrode over a substrate;2) partially oxidizing a metal of the bottom electrode through dry-oxygen oxidation or wet-oxygen oxidation to form a metal oxide with a thickness of 3 nm to 50 nm as a resistive material layer; and3) fabricating a top electrode over the resistive material layer.2. The method of claim 1 , wherein claim 1 , the bottom electrode and the top electrode are fabricated by using a PVD method or other film formation method in IC process.3. The method of claim 1 , wherein claim 1 , the bottom electrode is W electrode claim 1 , Ta electrode claim 1 , Ti electrode claim 1 , Al electrode claim 1 , Y electrode or Hf electrode.4. The method of claim 1 , wherein claim 1 , the metal of the bottom electrode has a thickness in a range of 100 nm-300 nm.5. The method of claim 1 , wherein claim 1 , the top electrode is Pt electrode claim 1 , TiN electrode claim 1 , Cu electrode or Ag electrode.6. The method of claim 1 , wherein claim 1 , a protection electrode is formed on the top electrode claim 1 , and the ...

SUBSTITUTED HETERO-BIARYL COMPOUNDS AND THEIR USES

The present invention provides a compound of formula (II): 2. (canceled)3. A compound of claim 1 , wherein Ais CH and Ais CH.4. A compound of claim 1 , wherein Ais CH and Ais N.5. (canceled)6. A compound of claim 1 , wherein Ais NH.7. A compound of claim 1 , wherein Ais O.810-. (canceled)11. A compound of claim 1 , wherein Ris cyclohexyl substituted with —NRR claim 1 ,{'sub': 12', '18', '1-6', '1-6', '3-6', '3-6', '22', '12', '22', '0-2', '12', '22', '2', '13', '14', '22', '12', '22', '19', '22', '19', '22', '13', '14', '22', '15', '2', '12', '22', '23', '24', '22', '15', '19', '22', '15', '2', '22', '15', '12', '22', '15', '13', '14, 'wherein Rand Rare each, independently, selected from the group consisting of hydrogen, hydroxyl, Calkyl, Chaloalkyl, Cbranched alkyl, Ccycloalkyl, —R—OR, —R—S(O)R, —R—S(O)NRR, —R—C(O)OR, —R—C(O)R, —R—OC(O)R, —R—C(O)NRR, —R—NRS(O)R, —R—NRR, —R—NRC(O)R, —R—NRC(O)OCHPh, —R—NRC(O)OR, —R—NRC(O)NRR, cyclo alkyl, heterocycloalkyl and heteroaryl;'}{'sub': 17', '18', '20', '21, 'or Rand Ralong with the nitrogen atom to which they are attached can be taken together to form a four to six or seven membered heterocyclic ring that can contain an additional O, N or S as a ring member, wherein the carbon atoms of said ring are optionally substituted with R, and the nitrogen atoms of said ring are optionally substituted with R.'}12. (canceled)1415-. (canceled)17. The compound of claim 16 , wherein Z is CN.1823-. (canceled)26. (canceled)27. The compound of claim 25 , wherein Ais NH.28. The compound of claim 25 , wherein Ais O.2934-. (canceled)36. The compound of claim 1 , which is selected from:1-(((5′-chloro-2′-((trans-4-(((R)-1-methoxypropan-2-yl)amino)cyclohexyl)amino)-[2,4′-bipyridin]-6-yl)amino)methyl)cyclopropanecarbonitrile4-(((2′-(azetidin-3-ylamino)-5′-chloro-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile4-(((5′-chloro-2′-(piperidin-4-ylamino)-[2,4′-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile5′-chloro ...

3-(AMINOARYL)-PYRIDINE COMPOUNDS

The present invention provides a compound of formula (I): 24-. (canceled)5. The compound of claim 1 , wherein: Ris selected from halogen claim 1 , CN claim 1 , CF claim 1 , O—C-alkyl claim 1 , and C-alkyl.6. (canceled)7. The compound of claim 1 , wherein Ris Cl or F.10. A compound of claim 1 , wherein Ris substituted cyclohexyl.11. The compound of claim 1 , wherein Ais NH.12. The compound of claim 1 , wherein Ais O.13. The compound of claim 1 , wherein X is a bond.14. (canceled)15. A compound of claim 1 , wherein Ris cyclohexyl substituted with —NRR claim 1 ,{'sub': 17', '18', '1-6', '1-6', '3-6', '3-6', '22', '12', '22', '0-2', '12', '22', '2', '13', '14', '22', '12', '22', '19', '22', '19', '22', '13', '14', '22', '15', '2', '12', '22', '23', '24', '22', '15', '19', '22', '15', '2', '22', '15', '12', '22', '15', '13', '14, 'wherein Rand Rare each, independently, selected from the group consisting of hydrogen, hydroxyl, Calkyl, Chaloalkyl, Cbranched alkyl, Ccycloalkyl, —R—OR, —R—S(O)R, —R—S(O)NRR, —R—C(O)OR, —R—C(O)R, —R—OC(O)R, —R—C(O)NRR, —R—NRS(O)R, —R—NRR, —R—NRC(O)R, —R—NRC(O)OCHPh, —R—NRC(O)OR, —R—NRC(O)NRR, cycloalkyl, heterocycloalkyl and heteroaryl;'}{'sub': 17', '18', '20', '21, 'or Rand Ralong with the nitrogen atom to which they are attached can be taken together to form a four to six or seven membered heterocyclic ring that can contain an additional O, N or S as a ring member, wherein the carbon atoms of said ring are optionally substituted with R, and the nitrogen atoms of said ring are optionally substituted with R.'}16. The compound of claim 1 , wherein:{'sub': 1', '16, 'Ris —X—Rwherein X is a bond; and'}{'sub': 16', '4-6', '4-8', '5-10, 'Ris selected from the group consisting of Ccycloalkyl, Cheterocycloalkyl, phenyl, and Cheteroaryl,'}{'sub': 16', '1-3', '3-6', '1-2', '22', '12', '1-2', '12', '12', '22', '12', '19', '22', '19', '13', '14', '15', '2', '12', '17', '18', '22', '17', '18', '15', '19', '22', '15', '19', '15', '2, 'wherein Ris ...

Triazole compounds as ksp inhibitors

The present invention provides triazole compounds of Formula I: as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula I.

VIDEO WATERMARK IDENTIFICATION METHOD AND APPARATUS, DEVICE, AND STORAGE MEDIUM

Disclosed are a video watermark identification method and apparatus, device, and a storage medium. The method includes: each video frame of multiple video frames of a video is divided into multiple image blocks to obtain an image sequence corresponding to the each video frame; multiple image sequences corresponding to the multiple video frames are input to a target detection model to obtain a classification result of each image block, and a feature vector of the video is obtained according to all classification results of the multiple image blocks; and the feature vector of the video is input to a watermark identification model to obtain a watermark identification probability output by the watermark identification model, and the video containing a watermark is determining in a case where the watermark identification probability is greater than or equal to a probability threshold. 1. A video watermark identification method , comprising:dividing each video frame of a plurality of video frames of a video into a plurality of image blocks to obtain an image sequence corresponding to the each video frame; inputting a plurality of image sequences corresponding to the plurality of video frames to a target detection model to obtain a classification result of each image block of the plurality of image blocks, and obtaining a feature vector of the video according to all classification results of the plurality of image blocks; andinputting the feature vector of the video to a watermark identification model to obtain a watermark identification probability output by the watermark identification model, and determining that the video contains a watermark in a case where the watermark identification probability is greater than or equal to a probability threshold.2. The method of claim 1 , wherein the each image block has a plurality of classification results;obtaining the feature vector of the video according to the all classification results of the plurality of image blocks ...

METHODS AND DEVICES FOR PERFORMING THREE-DIMENSIONAL BLOOD VESSEL RECONSTRUCTION USING ANGIOGRAPHIC IMAGE

The disclosure provides a method, device and a computer-readable medium for performing three-dimensional blood vessel reconstruction. The computer-implemented method includes receiving a first two-dimensional image of a blood vessel of a patient, where the first two-dimensional image is a projection image acquired in a first projection direction. The method further includes reconstructing, by a processor, a three-dimensional model of the blood vessel based on at least the first two-dimensional image. The method additional includes adjusting the three-dimensional model of the blood vessel, based on a comparison of a first optical path length determined from a second two-dimensional image of the blood vessel of the patient and a second optical path length determined from the three-dimensional model. 1. A computer-implemented method for performing three-dimensional blood vessel reconstruction , wherein the computer-implemented method comprises:receiving a first two-dimensional image of a blood vessel of a patient, wherein the first two-dimensional image is a projection image acquired in a first projection direction;reconstructing, by a processor, a three-dimensional model of the blood vessel based on at least the first two-dimensional image; andadjusting the three-dimensional model of the blood vessel, based on a comparison of a first optical path length determined from a second two-dimensional image of the blood vessel of the patient and a second optical path length determined from the three-dimensional model.2. The computer-implemented method according to claim 1 , wherein the first two-dimensional image acquired in a first projection direction is used as the second two-dimensional image.3. The computer-implemented method according to claim 1 , wherein the second two-dimensional image is another projection image acquired in a second projection direction different from the first projection direction.4. The computer-implemented method according to claim 1 , further ...

RESISTIVE MEMORY WITH SMALL ELECTRODE AND METHOD FOR FABRICATING THE SAME

Systems and methods are disclosed involving a resistive memory with a small electrode, relating to the field of semiconductor resistive memory in ULSI. An illustrative resistive memory may include an Al electrode layer, a SiOlayer, a Si layer, a resistive material layer and a lower electrode layer in sequence, wherein the Al electrode layer and the resistive material layer are electrically connected through one or more conductive channel and the conductive channel is formed by penetrating Al material into the Si layer via defects in the SiOlayer and dissolving Si material into the Al material. Methods may include forming a lower electrode layer, a resistive layer, a Si layer and a SiOlayer over a substrate; fabricating a Al electrode layer over the SiOlayer; and performing an anneal process to the resultant structure. Consistent with innovations herein, a small electrode may be obtained via a conventional process. 1. A resistive memory with a small electrode , comprising , an Al electrode layer , a SiOlayer , a Si layer , a resistive material layer and a lower electrode layer in sequence , wherein , the Al electrode layer and the resistive material layer are electrically connected through one or more conductive channel and the conductive channel is formed by penetrating Al material into the Si layer via defects in the SiOlayer and dissolving Si material into the Al material.2. The resistive memory according to claim 1 , wherein claim 1 , the thickness of the Si layer is determined on V/A claim 1 , wherein claim 1 , V is a diffusion distance of Si material in Al material and A represents the contact area between Al and Si in the conductive channel.3. The resistive memory according to claim 2 , wherein claim 2 , the thickness of the Si layer is larger than 100 nm and the thickness of the SiOlayer is about 100 nm.4. The resistive memory according to claim 3 , wherein claim 3 , the material of the resistive layer is made of hafnium oxide and the bottom electrode layer ...

AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS

The present invention provides a compound of Formula (I) or a salt thereof; 14-. (canceled)5. A method of treating non-small cell lung cancer comprising administering to a subject in need of such treatment a therapeutically effective amount of 4-(3-amino-6-((1S ,3S ,4R)-3-fluoro-4-hydroxycyclohexyl)pyrazin-2-yl)-N—((S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl)-2-fluorobenzamide , or a pharmaceutically acceptable salt thereof.6. A method of treating ovarian cancer comprising administering to a subject in need of such treatment a therapeutically effective amount of N—((S)-2-amino-1-(3-bromo-5-fluorophenyl)ethyl)-4-(3-amino-6-((1R ,3 S ,4R)-3-fluoro-4-hydroxycyclohexyl)pyrazin-2-yl)-2-fluorobenzamide , or a pharmaceutically acceptable salt thereof.7. A method of treating ovarian cancer comprising administering to a subject in need of such treatment a therapeutically effective amount of 4-(3-amino-6-((1S ,3S ,4R)-3-fluoro-4-hydroxycyclohexyl)pyrazin-2-yl)-N—((S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl)-2-fluorobenzamide , or a pharmaceutically acceptable salt thereof.8. A method of treating non-small cell lung cancer comprising administering to a subject in need of such treatment a therapeutically effective amount of N—((S)-2-amino-1-(3-bromo-5-fluorophenyl)ethyl)-4-(3-amino-6-((1R ,3S ,4R)-3-fluoro-4-hydroxycyclohexyl)pyrazin-2-yl)-2-fluorobenzamide , or a pharmaceutically acceptable salt thereof. This application is a continuation of U.S. patent application Ser. No. 14/964,057, filed Dec. 9, 2015, which is a divisional of U.S. patent application Ser. No. 14/527,328, filed Oct. 29, 2014, which claims priority under 35 U.S.C. §119 to International Application No. PCT/CN2014/088409, filed Oct. 11, 2014, and claims benefit of U.S. Provisional Application No. 61/898,761, filed Nov. 1, 2013.The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ...

BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent. 120-. (canceled)22. A pharmaceutical composition comprising a compound of or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers.23. A combination comprising a therapeutically effective amount of a compound according to or a pharmaceutically acceptable salt thereof and one or more therapeutically active co-agents.24. A method of treating a proliferative disorder selected from non-small cell lung cancer and ovarian cancer claim 31 , comprising administering to a subject in need thereof a therapeutically effective amount of a compound of or a pharmaceutically acceptable salt thereof.2527-. (canceled) The invention provides compounds that inhibit Raf kinases, and are accordingly useful for treating certain disorders associated with excessive Raf kinase activity, including cell proliferation disorders such as cancers. The invention further provides pharmaceutical compositions containing these compounds and methods of using these compounds to treat conditions including cancer.Protein Kinases are involved in very complex signaling cascades that regulate most cellular functions, including cell survival and proliferation. These signaling pathways have been heavily studied, particularly in the context of disorders caused by dysregulated cellular function, such as cancer. The mitogen-activated protein kinase (MAPK) cascade has been studied extensively, for example, and kinases in this pathway (e.g., RAS, RAF, MEK, and ERK) have been exploited as target sites for drug discovery. Mutated B-Raf is found in a significant fraction of malignancies (over 30% of all tumors and 40% of ...

PREFETCHING RDF TRIPLE DATA

Query requests for RDF triples are obtained, wherein the query request(s) contain(s) at least one triple pattern; for each triple pattern, the corresponding elementary pattern is determined, and each triple pattern is converted to a weighted elementary pattern. The occurrence frequency of each elementary pattern is computed based on the weighted elementary patterns; at least one elementary pattern is chosen at least according to the occurrence frequency; and the RDF triples corresponding to the chosen at least elementary pattern are prefetched into the buffer. The corresponding apparatus is also provided. With the above method and apparatus, the frequently accessed RDF triples can be determined and prefetched into the buffer, which improves the query efficiency. 1. A method for processing Resource Description Framework triples , comprising:obtaining query requests for the Resource Description Framework triples, wherein the query requests each contain at least one triple pattern of elements including a subject s, a predicate p, and an object o;determining elementary patterns corresponding to the triple patterns, wherein each of the elementary patterns includes one of the elements of the triple patterns denoted as a constant and remaining ones of the elements denoted as query variables;obtaining weighted elementary patterns by performing weighting with respect to the triple patterns corresponding to the elementary patterns;computing occurrence frequency of the elementary patterns in the query requests based on the weighted elementary patterns; andprefetching those of the Resource Description Framework triples corresponding to the elementary patterns into a buffer in decreasing order of the occurrence frequency of the elementary patterns, wherein a total size of prefetched ones of the triples corresponding to each of the elementary patterns is less than a size of the buffer.2. The method of claim 1 , wherein obtaining the query requests for the Resource Description ...

TRANSPARENT FLEXIBLE RESISTIVE MEMORY AND FABRICATION METHOD THEREOF

The present invention discloses a transparent flexible resistive memory and a fabrication method thereof. The transparent flexible resistive memory includes a transparent flexible substrate, a memory unit with a MIM capacitor structure over the substrate, wherein a bottom electrode and a top electrode of the memory unit are transparent and flexible, and an intermediate resistive layer is a transparent flexible film of poly(p-xylylene). Poly(p-xylylene) has excellent resistive characteristics. In the device, the substrate, the electrodes and the intermediate resistive layer are all formed of transparent flexible material so that a completely transparent flexible resistive memory which can be used in a transparent flexible electronic system is obtained. 1. A resistive memory comprising a transparent flexible substrate , a memory unit with a MIM capacitor structure over the substrate , wherein a bottom electrode and a top electrode of the memory unit are transparent and flexible , and an intermediate resistive layer is a transparent film of poly(p-xylylene).2. The resistive memory according to claim 1 , wherein claim 1 , the substrate is a poly(p-xylylene) film claim 1 , a polydimethylsiloxane film claim 1 , a polyethylene terephthalate film or a poly(ethylene naphthalate) film.3. The resistive memory according to claim 1 , wherein claim 1 , materials of the transparent flexible electrodes are indium tin oxide claim 1 , ZnO claim 1 , graphene or poly(3 claim 1 ,4-ethylenedioxythiophene).4. The resistive memory according to claim 1 , wherein claim 1 , the poly(p-xylylene) is a polymer of poly(p-xylylene)-C claim 1 , poly(p-xylylene)-N or poly(p-xylylene)-D.5. The resistive memory according to claim 1 , wherein claim 1 , the thickness of the substrate is in a range of 2-500 μm claim 1 , the thicknesses of the bottom electrode and the top electrode are in a range of 100-500 nm claim 1 , and the thickness of the intermediate resistive layer is in a range of 30-50 nm.6. A ...

METHOD AND SYSTEM FOR JOINT NAMED ENTITY RECOGNITION AND RELATION EXTRACTION USING CONVOLUTIONAL NEURAL NETWORK

Embodiments of the disclosure provide systems and methods for processing unstructured texts in a medical record. A disclosed system includes at least one processor configured to determine a plurality of word representations of an unstructured text and tag entities in the unstructured text by performing a named entity recognition task on the plurality of word representations. The at least one processor is further configured to determine position embeddings based on positions of words in the unstructured text relative to positions of the tagged entities and concatenate the plurality of word representations with the position embeddings. The at least one processor is also configured to determine relation labels between pairs of tagged entities by performing a relationship extraction task on the concatenated word representations and position embeddings. 1. A system for processing unstructured texts in a medical record , comprising: determine a plurality of word representations of an unstructured text;', 'tag entities in the unstructured text by performing a named entity recognition task on the plurality of word representations;', 'determine position embeddings based on positions of words in the unstructured text relative to positions of the tagged entities;', 'concatenate the plurality of word representations with the position embeddings; and', 'determine relation labels between pairs of tagged entities by performing a relationship extraction task on the concatenated word representations and position embeddings., 'at least one processor, configured to2. The system of claim 1 , wherein the plurality of word representations include an attention-based subword representation determined by applying a convolutional neural network on subwords within the words.3. The system of claim 2 , wherein applying a convolutional neural network on characters within the words further includes:breaking the words down to the subwords;mapping the subwords to a sequence of embeddings; ...

Time Correlation Learning Neuron Circuit Based on a Resistive Memristor and an Implementation Method Thereof

The present invention discloses a time correlation learning neuron circuit based on a resistive memristor and an implementation method thereof. The present invention utilizes switching characteristics of the resistive memristor. When two terminals of the resistive memristor are selected synchronously by two excitation signals, the voltage drop between these two terminals will change the resistance value of memristor, thereby achieving the on-off of a synapse connection and achieving the correction of the two excitation signals. Meanwhile the device also has a memory characteristic. Also, the previous excitation signal can be repeated. That is, the purpose of learning is achieved. Since the resistive memristor has a simple structure and a high degree of integration, it can achieve large-scale physical synapse connection in order to achieve more complex learning and even logic functions. The present invention has a good application prospect in a neuron cell computation. 1123112. A time correlation learning neuron cell circuit , including two neuron cell circuits () and () , and a resistive memristor () as a synapse connection between the two neuron cell circuits , each neuron cell circuit further including a excitation signal terminal P , a synapse connection terminal M , a buffer , a control signal inverter N , a first transmission gate T and a second transmission gate T; wherein ,{'b': '2', 'an output terminal out of the buffer is connected to the excitation signal terminal P, and an input terminal in of the buffer is connected to one signal terminal of the second transmission gate T;'}{'b': 1', '1', '2', '1', '1', '2, 'o': [{'@ostyle': 'single', 'S'}, {'@ostyle': 'single', 'S'}], 'an input terminal in of the control signal inverter N is connected to the excitation signal terminal P, a positive control terminal S of the first transmission gate T and a negative control terminal of the second transmission gate T, and an output terminal out of the control signal ...

Hardware-based time synchronization for heterogeneous sensors in autonomous vehicles

Devices, systems, and methods for hardware-based time synchronization for heterogenous sensors are described. An example method includes generating a plurality of input trigger pulses having a nominal pulse-per-second (PPS) rate, generating, based on timing information derived from the plurality of input trigger pulses, a plurality of output trigger pulses, and transmitting the plurality of output trigger pulses to a sensor of a plurality of sensors, wherein a frequency of the plurality of output trigger pulses corresponds to a target operating frequency of the sensor, wherein, in a case that a navigation system coupled to the synchronization unit is functioning correctly, the plurality of input trigger pulses is generated based on a nominal PPS signal from the navigation unit, and wherein, in a case that the navigation system is not functioning correctly, the plurality of input trigger pulses is generated based on a simulated clock source of the synchronization unit.

AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS

The present invention provides a compound of Formula (I) or a salt thereof; 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:Z is N or CH;{'sup': '2', 'Ris H or Me;'}{'sup': 5', '5a', '5a', '5a, 'sub': 3-8', '1-4', '1-4', '1-4', '1-4', '1-4', '2', '2', '2', '2', '1-4, 'Ris selected from —C(O)—Rand R; wherein Ris selected from Ccycloalkyl, 5-8 membered heterocyclyl containing 1-2 heteroatoms selected from N, O and S, phenyl, and 5-6 membered heteroaryl, and is optionally substituted with 1-3 groups independently selected from D, halo, CN, hydroxy, Calkoxy, Calkyl, Chaloalkyl, Chydroxyalkyl, Chaloalkoxy, —SOR′, —N(R′), —NR′—C(O)—R′, and —SONR′, where each R′ is independently H or Calkyl; and'}{'sup': '6', 'Ris H.'}3. The compound of claim 2 , wherein Ris selected from —C(O)—Rand R; wherein Ris selected from phenyl claim 2 , pyridine claim 2 , pyridone claim 2 , pyrazine claim 2 , pyridazine claim 2 , pyrazole claim 2 , triazole claim 2 , tetrazole claim 2 , thiazole claim 2 , oxazole claim 2 , imidazole claim 2 , isothiazole claim 2 , isoxazole claim 2 , furan claim 2 , and thiophene claim 2 , each of which is optionally substituted with one or two groups independently selected from halo claim 2 , D claim 2 , CN claim 2 , Calkyl claim 2 , Calkoxy claim 2 , Chaloalkyl claim 2 , Chydroxyalkyl claim 2 , Chaloalkoxy claim 2 , CN claim 2 , COOR claim 2 , CON(R) claim 2 , and —SOR claim 2 , where each Ris independently H or Calkyl.4. The compound of or a pharmaceutically acceptable salt thereof claim 8 , wherein Ris selected from —C(O)—Rand R; wherein Ris pyrazole or triazole and is optionally substituted with 1-2 groups independently selected from halo claim 8 , CN claim 8 , Calkyl claim 8 , Chaloalkyl claim 8 , Chydroxyalkyl claim 8 , Calkoxy claim 8 , and Chaloalkoxy.5. The compound of claim 2 , wherein Ris selected from —C(O)—Rand R; wherein Ris selected from cyclobutyl claim 2 , cyclopentyl claim 2 , cyclohexyl claim 2 , ...

METHOD AND APPARATUS FOR DATA PROCESSING

This application generally relates to data processing methods and apparatus. One data processing method disclosed herein comprises: creating a Writable Snapshot based on data modification; creating a plurality of Read-Only (“RO”) Snapshots by cloning the Writable Snapshot at distinct predetermined creation-times; receiving a data inquiry request; and conducting the data inquiry through indexing, in a RO Snapshot with a latest creation-time. This approach achieves separation of data modification and data inquiry, enabling efficient real-time updating. Further, by fast indexing and invert indexing, inquiry efficiency is further improved. Additionally, data is stored in data columns, wherein each column may be divided into multiple data blocks according to a fixed block size, and each data block has a same length. When modifying data, effect of the modification may be limited to the data blocks being modified, without affecting the other data blocks, which reduces resource consumption incurred by data modification. 114.-. (canceled)15. A data processing method performed by a data storage system , the method comprising:creating a Writable Snapshot based on data modification;creating a plurality of Read-Only (“RO”) Snapshots by cloning the Writable Snapshot at distinct predetermined creation-times;receiving a data inquiry request; andconducting the data inquiry through indexing, in a RO Snapshot with a latest creation-time.16. The method according to claim 15 , wherein the RO Snapshots share a same data structure with the Writable Snapshot claim 15 , wherein the data structure stores data in data columns claim 15 , each data column including one or more data blocks claim 15 , and each data block including a same number of data sub-blocks.17. The method of claim 15 , wherein the step of creating a Writable Snapshot based on data modification comprises:determining the RO Snapshot with the latest creation-time;duplicating data information associated with the determined RO ...

BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS

The present invention provides compounds of Formula (I) 2. The method of wherein the proliferative disease is a cancer selected from solid tumors claim 1 , melanoma claim 1 , breast cancer claim 1 , non-small cell lung cancer claim 1 , lung adenocarcinoma claim 1 , sarcoma claim 1 , gastrointestinal stromal tumors claim 1 , ovarian cancer claim 1 , colorectal cancer claim 1 , thyroid cancer and pancreatic cancer.3. The method of wherein the proliferative disease is melanoma.5. The method of wherein the proliferative disease is a cancer selected from solid tumors claim 4 , melanoma claim 4 , breast cancer claim 4 , non-small cell lung cancer claim 4 , lung adenocarcinoma claim 4 , sarcoma claim 4 , gastrointestinal stromal tumors claim 4 , ovarian cancer claim 4 , colorectal cancer claim 4 , thyroid cancer and pancreatic cancer.6. The method of wherein the proliferative disease is melanoma.8. The method of wherein the one or more therapeutically active co-agents is a RAF pathway inhibitor selected from paclitaxel claim 7 , docetaxel claim 7 , temozolomide claim 7 , platins claim 7 , doxorubicins claim 7 , vinblastins claim 7 , cyclophosphamide claim 7 , topotecan claim 7 , gemcitabine claim 7 , ifosfamide claim 7 , etoposide and irinotecan.9. The method of wherein the proliferative disease is a cancer selected from solid tumors claim 8 , melanoma claim 8 , breast cancer claim 8 , non-small cell lung cancer claim 8 , lung adenocarcinoma claim 8 , sarcoma claim 8 , gastrointestinal stromal tumors claim 8 , ovarian cancer claim 8 , colorectal cancer claim 8 , thyroid cancer and pancreatic cancer.10. The method of wherein the proliferative disease is melanoma. This application is a Divisional of U.S. patent application Ser. No. 15/601,423, filed on May 22, 2017, which is a Divisional of U.S. patent application Ser. No. 14/774,431, filed on Sep. 10, 2015, now U.S. Pat. No. 9,694,016, which is a 371 of international application PCT/US2014/026107, filed on Mar. 13, 2014, ...

Aminoheteroaryl benzamides as kinase inhibitors

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

HETEROARYL COMPOUNDS AND THEIR USES

The present invention provides a compound of formula (I): 2. The method of claim 1 , wherein:{'sub': '8', 'Ris Cl.'}3. The method of claim 1 , wherein:{'sub': 1', '16, 'Ris X—R;'}{'sub': '1-2', 'X is a bond, or Calkyl;'}{'sub': 16', '1-2', '4-6, 'Ris selected from the group consisting of C-alkyl, Ccycloalkyl, heterocycloalkyl, phenyl, and heteroaryl;'}{'sub': 16', '1-3', '3-6', '1-2', '22', '12', '1-2', '12', '12', '22', '12', '19', '22', '19', '13', '14', '15', '2', '12', '17', '18', '22', '17', '18', '15', '19', '22', '15', '19', '15', '2, 'wherein Ris substituted with one to three groups independently selected from halogen, hydrogen, Calkyl, Cbranched alkyl, OH, Calkoxy, R—OR, S(O)R, C(O)OR, R—C(O)OR, C(O)R, R—OC(O)R, C(O)NRR, NRS(O)R, NRR, R—NRR, NRC(O)R, R—NRC(O)R, and NRC(O)OCHPh.'}5. The method of wherein:{'sub': 3', '2, 'Ris selected from H, methyl, cyano, chloro, CONH, amino, cyclopropyl, ethyl, and fluoro;'}{'sub': '4', 'Ris selected from halogen, methyl, hydrogen, and halo-methyl;'}{'sub': '6', 'Ris H;'}{'sub': 7', '2', '3, 'Ris selected from H, COOH, Cl, F, CONH, CN, and CF;'}{'sub': '8', 'Ris Cl;'}{'sub': 17', '18', '1-3', '1-4', '3-6', '22', '12', '22', '2', '12', '22', '15', '2', '12', '17', '18', '20', '21, 'Rand Rare each, independently, selected from the group consisting of hydrogen, Calkyl, Chaloalkyl, Cbranched alkyl, R—OR, R—S(O)R, R—NRS(O)R, heterocycloalkyl or heteroaryl; alternatively, Rand Ralong with the nitrogen atom to which they are attached to can be taken together to form a four to six membered heterocyclic ring wherein said ring carbon atoms are optionally substituted with R, and the ring nitrogen atoms are optionally substituted with R;'}{'sub': 19', '1-3, 'Ris selected from C-alkyl, optionally substituted heterocycloalkyl, optionally substituted aryl or optionally substituted heteroaryl;'}{'sub': 20', '1-3, 'Rrepresents the group Calkyl; and'}{'sub': 22', '1-4', '3-6, 'Ris selection from the group consisting of Calkyl, and Cbranched ...

POWER MANAGEMENT SYSTEM FOR AUTONOMOUS VEHICLES

A power management system is disclosed for managing power in a vehicle. The system may include a power distribution unit (PDU) communicably coupled to a power controller unit located in the vehicle. The power controller unit comprises a microcontroller configured to: receive, from the PDU, a temperature value that indicates a temperature of the PDU, one or more voltage values from the one or more voltage sensors, or one or more current values from the one or more current sensors, perform a determination that the temperature value, the one or more voltage values, or the one or more current values are below one or more of their respective pre-determined threshold values, and send, after the determination, a health status message to a computer located in the vehicle, where the health status message indicates that the PDU is operating in a safe operating condition. 1. A system for managing power in a vehicle , comprising: an input connector configured to receive electrical power from a power source in the vehicle,', 'one or more output connectors configured to provide electrical power to one or more devices on or in the vehicle,', 'one or more relays, wherein each relay is electrically coupled in between the input connector and one of the one or more output connectors,', 'a temperature sensor,', 'one or more voltage sensors associated with the one or more output connectors, and', 'one or more current sensors associated with the one or more output connectors;, 'a power distribution unit (PDU) located in the vehicle, and comprising receive, from the PDU, a temperature value that indicates a temperature of the PDU, one or more voltage values from the one or more voltage sensors, or one or more current values from the one or more current sensors;', 'perform a determination that the temperature value, or the one or more voltage values, or the one or more current values is below one or more of their respective pre-determined threshold values; and', 'send, after the ...

Method and Apparatus of Processing Retransmission Request in Distributed Computing

A method and an apparatus for processing a retransmission request in distributed computing are disclosed. The method includes obtaining a retransmission request to be processed in distributed computing; determining a target copy partition corresponding to the retransmission request based on respective partition response time information of individual copy partitions; sending the retransmission request to the target copy partition. Compared with existing technologies, the present disclosure distinguishes each partition with one another based on a partition response time of the respective copy partition to determine a target copy partition corresponding to a retransmission request, thus selecting a copy with a better response time during retransmission, reducing a response time for the retransmission request and reducing an overall load of an associated cluster. 1. A method comprising:obtaining a retransmission request to be processed in distributed computing;determining a target copy partition corresponding to the retransmission request based at least in part on respective partition response times of copy partitions in the distributed computing; andsending the retransmission request to the target copy partition.2. The method of claim 1 , wherein sending the retransmission request to the target copy partition comprises:detecting whether the retransmission request satisfies a request retransmission condition; andsending the retransmission request to the target copy partition in response to the retransmission request satisfying the request retransmission condition.3. The method of claim 2 , wherein detecting whether the retransmission request satisfies the request retransmission condition comprises determining whether the retransmission request satisfies the request retransmission condition based at least in part on a partition response time of the target copy partition and a maximum timeout time corresponding to the retransmission request.4. The method of claim 1 , ...

Anti-pancreatic cancer monoclonal antibody and use thereof

A hybridoma cell line NM002-1 secreting an anti-human pancreatic cancer monoclonal antibody and deposited under CCTCC Accession NO: C201173. Also, an anti-human pancreatic cancer monoclonal antibody NJ002-1 secreted by the hybridoma cell line NM002-1 and use thereof.

Multi-Value Nonvolatile Organic Resistive Random Access Memory and Method for Preparing the Same

Disclosed are a multi-value nonvolatile organic resistive random access memory and a method for preparing the same. The resistive random access memory comprises a top electrode, a bottom electrode and a middle functional layer located between the top electrode and the bottom electrode, the middle functional layer is at least two layers of parylene. The method comprises the steps of: growing material for the bottom electrode using physical vapor deposition method on a substrate; growing sequentially multiple layers of parylene on the bottom electrode by polymer chemical vapor deposition; defining the via for leading out the bottom electrode by lithography and etching; growing material for the top electrode on the parylene materials by using physical vapor deposition process, defining the top electrode material by lithography and lift-off, and leading out the bottom electrode. 1. A multi-value nonvolatile organic resistive random access memory , comprising a top electrode , a bottom electrode and a middle functional layer located between the top electrode and the bottom electrode , the middle functional layer is at least two layers of parylene.2. The multi-value nonvolatile organic resistive random access memory according to claim 1 , wherein the top electrode and the bottom electrode each are an inert electrode.3. The multi-value nonvolatile organic resistive random access memory according to claim 2 , wherein the top electrode and the bottom electrode each are a W electrode claim 2 , and have a thickness between 200 nm and 500 nm.4. The multi-value nonvolatile organic resistive random access memory according to claim 1 , wherein a total thickness of the parylene as the functional layer is between 40 nm and 80 nm claim 1 , each layer of the parylene has a thickness between 10 nm and 20 nm.5. The multi-value nonvolatile organic resistive random access memory according to claim 1 , wherein a polymer of the parylene is parylene-C type claim 1 , parylene-N type or ...

META-DATA INPUTS TO FRONT END PROCESSING FOR AUTOMATIC SPEECH RECOGNITION

A computer-implemented method is described for front end speech processing for automatic speech recognition. A sequence of speech features which characterize an unknown speech input provided on an audio input channel and associated meta-data data which characterize the audio input channel are received. The speech features are transformed with a computer process that uses a trained mapping function controlled by the meta-data, and automatic speech recognition is performed of the transformed speech features. 1. A computer-implemented method employing at least one hardware implemented computer processor for front end speech processing for automatic speech recognition , the method comprising: i. a sequence of speech features which characterize an unknown speech input provided on an audio input channel, and', 'ii. associated meta-data which characterize the input audio channel;, 'receiving with a computer processtransforming the speech features with a computer process using a trained mapping function controlled by the meta-data; andusing a computer process to perform automatic speech recognition of the transformed speech features.2. A method according to claim 1 , wherein the meta-data includes meta-data characterizing a source channel which generates the unknown speech input.3. A method according to claim 1 , wherein the meta-data includes meta-data characterizing a source environment in which the unknown speech input is generated.4. A method according to claim 1 , wherein the meta-data includes meta-data characterizing a source application which generates the unknown speech input.5. A method according to claim 1 , wherein the meta-data includes meta-data characterizing an audio codec applied when generating the speech features.6. A method according to claim 1 , wherein the trained mapping function includes a multilayered perceptron (MLP) mapping function.7. A method according to claim 1 , wherein the trained mapping function includes a deep belief network (DBN) mapping ...

BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent. 131-. (canceled)331. A pharmaceutical composition comprising a compound of claim or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers.341. A combination comprising a therapeutically effective amount of a compound according to claim or a pharmaceutically acceptable salt thereof and one or more therapeutically active co-agents.351. A method of treating a proliferative disorder selected from non-small cell lung cancer and ovarian cancer , comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim or a pharmaceutically acceptable salt thereof. The invention provides compounds that inhibit Raf kinases, and are accordingly useful for treating certain disorders associated with excessive Raf kinase activity, including cell proliferation disorders such as cancers. The invention further provides pharmaceutical compositions containing these compounds and methods of using these compounds to treat conditions including cancer.Protein Kinases are involved in very complex signaling cascades that regulate most cellular functions, including cell survival and proliferation. These signaling pathways have been heavily studied, particularly in the context of disorders caused by dysregulated cellular function, such as cancer. The mitogen-activated protein kinase (MAPK) cascade has been studied extensively, for example, and kinases in this pathway (e.g., RAS, RAF, MEK, and ERK) have been exploited as target sites for drug discovery. Mutated B-Raf is found in a significant fraction of malignancies (over 30% of all tumors and 40% of melanomas ...

MEMORY AND ELECTRONIC DEVICE

A memory and an electronic device are provided. The memory includes a storage element (), a first transistor (), a second transistor (), a first bit line (BLA), and a second bit line (BLB). The storage element () is coupled to the first bit line (BLA) and the second bit line (BLB) by separately using the first transistor () and the second transistor (), and the first transistor () and the second transistor () are turned on during a write operation. When the foregoing solution is used, compared with providing a required write current by using one transistor, providing the write current by using the two transistors may enable a smaller transistor to meet a requirement, thereby reducing an area required by the entire memory. In addition, the memory in this application can still support a dual-port feature in a read operation. 1. A memory , comprising: a storage element , a first transistor , a second transistor , a first bit line , and a second bit line , wherein:the storage element is coupled to the first bit line and the second bit line separately via the first transistor and the second transistor; andthe first transistor and the second transistor are turned on together when a write operation is performed on the storage element.2. The memory according to claim 1 , wherein the memory further comprises a first word line and a second word line claim 1 , and the first word line and the second word line are respectively coupled to a gate of the first transistor and a gate of the second transistor.3. The memory according to claim 2 , wherein the memory further comprises a control circuit claim 2 , and the control circuit is configured to selectively turn on or off the first and second transistors by using the first word line and the second word line.4. The memory according to claim 1 , wherein the storage element is a magnetic tunnel junction.5. The memory according to claim 1 , wherein the storage unit comprises a first end and a second end claim 1 , and the first end is ...

TASK ALLOCATION METHOD AND SYSTEM

Embodiments of the present application provide a task allocation method and system. The method includes: analyzing at least one query pattern of a target task to acquire expected response time of the query pattern; estimating system cost information and estimated response time according to the query pattern and service description information; estimating node cost information of each processing node of a set of processing nodes in a computing system; selecting a processing node of the set of processing nodes according to the node cost information to allocate subtasks of the target task to the selected processing node; and determining an unallocated subtask in the target task to schedule the unallocated subtask according to the expected response time, the system cost information, and the estimated response time. 1. A task allocation method of a computing system , comprising:analyzing at least one query pattern of a target task to acquire expected response time of the query pattern;estimating system cost information and estimated response time according to the query pattern and service description information;estimating node cost information of each processing node of a set of processing nodes in the computing system;selecting a processing node of the set of processing nodes according to the node cost information to allocate subtasks of the target task to the selected processing node; anddetermining an unallocated subtask of the target task to schedule the unallocated subtask according to the expected response time, the system cost information, and the estimated response time.2. The method according to claim 1 , wherein estimating the system cost information and the estimated response time according to the query pattern and service description information further comprises:reading service description information of each query pattern, wherein the service description information is associated with service data of the computing system;estimating, according to the ...

INDEX ESTABLISHMENT METHOD AND DEVICE

Embodiments of the present invention provide an index establishment method and device. The method can include determining, according to index status information of a column in a database within a preset time threshold, whether an index is to be established for the column; determining an index type according to the data information of the column; and establishing the index for the column according to the index type based on the determination that the index is to be established for the column. 1. An index establishment method , comprising:determining, according to index status information of a column in a database within a time threshold, whether an index is to be established for the column;determining an index type according to the data information of the column; andestablishing an index for the column according to the index type based on a determination that an index is to be established for the column.2. The method of claim 1 , further comprising:in response to the determination that an index is not to be established for the column, determining, after the time threshold, whether an index is to be established for the column.3. The method of claim 2 , wherein determining claim 2 , according to the index status information of the column in the database within the preset time threshold claim 2 , whether an index is to be established for the column further comprises:acquiring the index status information of the column within the time threshold;determining, according to the index status information, whether a current index is used for the column within the time threshold;in response to the current index being used for the column within the time threshold, determining whether a number of times that the current index has been used within the time threshold is not less than a preset number-of-times threshold;determining that an index is not to be established for the column, in response to the current index not being used for the column within the time threshold or the ...

METHOD AND SYSTEM FOR INTRACEREBRAL HEMORRHAGE DETECTION AND SEGMENTATION BASED ON A MULTI-TASK FULLY CONVOLUTIONAL NETWORK

Embodiments of the disclosure provide systems and methods for detecting an intracerebral hemorrhage (ICH). The system includes a communication interface configured to receive a sequence of image slices and an end-to-end multi-task learning model. The sequence of image slices is the head scan images of a subject acquired by an image acquisition device. The end-to-end multi-task learning model includes an encoder, a bi-directional Convolutional Recurrent Neural Network (ConvRNN), a decoder, and a classifier. The system further includes at least one processor configured to extract feature maps from each image slice using the encoder, capture contextual information between adjacent image slices using the bi-directional ConvRNN, and detect the ICH of the subject using the classifier based on the extracted feature maps of the image slices and the contextual information or segment each image slice using the decoder to obtain an ICH region based on the extracted feature maps of the image slice. 1. A system for detecting an intracerebral hemorrhage (ICH) , comprising:a communication interface configured to receive a sequence of image slices and an end-to-end multi-task learning model, the sequence of image slices being head scan images of a subject acquired by an image acquisition device, the end-to-end multi-task learning model comprising an encoder, a bi-directional Convolutional Recurrent Neural Network (ConvRNN), a decoder, and a classifier; andat least one processor, configured to:extract feature maps from each image slice using the encoder;capture contextual information between adjacent image slices using the bi-directional ConvRNN; anddetect the ICH of the subject using the classifier based on the extracted feature maps of the image slices and the contextual information or segment each image slice using the decoder to obtain an ICH region based on the extracted feature maps of the image slice.2. The system of claim 1 , wherein the at least one processor is further ...

Memory and electronic device

Biaryl amide compounds as kinase inhibitors

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

PI3K-α INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-α enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-α signaling with the compounds and compositions of the disclosure.

Aminoheteroaryl benzamides as kinase inhibitors

The present invention provides a compound of Formula (1) or a sait thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Method and device for establishing index

AMINOETERALYL BENZAMIDS AS KINASE INhibitors

Η παρούσα εφεύρεση παρέχει μια ένωση του τύπου (I) ή ένα άλας αυτής και θεραπευτικές χρήσεις αυτών των ενώσεων. Η παρούσα εφεύρεση παρέχει περαιτέρω φαρμακευτικές συνθέσεις που περιέχουν αυτές τις ενώσεις, και συνθέσεις που περιέχουν αυτές τις ενώσεις με έναν θεραπευτικό συν- παράγοντα. The present invention provides a compound of formula (I) or a salt thereof and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions containing these compounds, and compositions containing these compounds with a therapeutic co-agent.

Pyridine and pyrazine derivatives as protein kinase modulators

The present invention provides a compound of formula (I), and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a diseease or condition mediated by CDK9.

Aminoheteroaryl benzamide as kinase inhibitor

【課題】細胞外シグナル調節キナーゼ（ＥＲＫ）を阻害し、がんなどの疾患を処置するのに有用な化合物の提供。【解決手段】下記式で表される化合物或いは光学的立体異性、又は薬学的に許容されるそれらの塩、さらに該化合物の誘導体を含む、医薬組成物。【選択図】なし

Task allocation method and system

Embodiments of the present application provide a task allocation method and system. The method includes: analyzing at least one query pattern of a target task to acquire expected response time of the query pattern; estimating system cost information and estimated response time according to the query pattern and service description information; estimating node cost information of each processing node of a set of processing nodes in a computing system; selecting a processing node of the set of processing nodes according to the node cost information to allocate subtasks of the target task to the selected processing node; and determining an unallocated subtask in the target task to schedule the unallocated subtask according to the expected response time, the system cost information, and the estimated response time.

Biaryl amide compounds as kinase inhibitors

PIRIDINE AND PIRAZINE DERIVATIVES AS PROTEIN KINase MODULATORS

La presente invención proporciona un conjunto de la fórmula (I); y las sales farmacéuticamente aceptables, enantiómeros, estereoisómeros, rotámeros, tautómeros, diaestereómeros, o racematos del mismo.

Data reading/writing method, memory, storage device, and terminal

Method and system for constructing xml query to schema variable xml documents

An XML querying method and system for constructing an XQuery/XPath query to a schema variable XML document. The method includes: receiving the query from a client computer; generating a tree structure; and generating, by query rewriting, an XQuery/XPath for the XML document based on the tree structure and configurable query constraints. The system includes: a tree structure generating unit for generating a tree structure; and a query writing unit for generating an XQuery/XPath query for the XML document based on the tree structure and configurable query constraints.

Pulse Condition Acquisition Apparatus And Method

A device and method for collecting sphygmus information; it includes a sensor component, said sensor component incorporates a electric machine fixed in the casing, a screw fixed with said electric machine, a lifting structure setting outside said screw, and a sensor probe fixed in the base of said lifting structure, said electric machine drives said screw to revolve when rotating, further makes said lifting structure ascended or descended relatively to said screw. The pulse signal collection can be automatically achieved, and limited protecting structure is employed in the collecting process.

System and method for metadata search

A system, a method, and a computer readable article of manufacture for metadata searching. The system includes: a receiving module for receiving a search query with respect to a plurality of metadata resources; a query module for parsing the search query and searching related metadata resources and the structural information among the related metadata resources according to the parsing of the search query; and an output module for outputting the search results so as to realize a fuzzy structural search with respect to the plurality of metadata resources. The method includes the steps of: receiving a search query that does not designate complete structural information of the metadata resources; parsing the search query and searching related metadata resources to form search results that include the complete structural information; and outputting the search results.

Aminoheteroaryl benzamides as kinase inhibitors

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Method for achieving four-bit storage using flash memory having splitting trench gate

The present invention discloses a method for achieving four-bit storage by using a flash memory having a splitting trench gate. The flash memory with the splitting trench gate is disclosed in a Chinese patent No. 200710105964.2. At one side that each of two trenches is contacted with a channel, a programming for electrons is achieved by using a channel hot electron injection method; and at the other side that each of the two trenches is contacted with a source or a drain, a programming for electrons is achieved by using an FN injection method, so that a function of a four-bit storage of the device is achieved by changing a programming mode. Thus, a performance of the device is improved while a storage density is greatly increased.

Triazole compounds as ksp inhibitors

The present invention provides triazole compounds of Formula (I) : as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula (I), and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula (I).

Method for storing inverted index, method for on-line updating the same and inverted index mechanism

The invention provides a method for storing inverted index based on an inverted file, the method comprising: creating an inverted file in a storage medium for storing the inverted index, the inverted file including a plurality of fixed-size index blocks, each of them including a plurality of fixed-size index units, wherein each index unit is used to store one piece of index information; and sequentially storing the index information related to each index item into the created inverted file, wherein the index information related to the same index item is stored in continuous blocks and the index units in each index block are only for storing index information related to the same index item. Since each index block is used only for storing index information related to the same index item, when performing operations on the index information in an index block, other index items are not affected, therefore, it is possible to on-line update index information in any index block.

Vehicle door handle with adjustment

Ein Fahrzeugtürgriff (1) mit einem Griffträger (2) und einer umgreifbaren Handhabe, die zwischen einer Ruheposition und einer Ausstellposition verstellbar ist. Handhabe (3) und Griffträger (2) sind über eine Führungsmechanik (5a, 5b) gekoppelt, ein Verstellhebel (12) ist mit der Führungsmechanik (5a, 5b) gekoppelt, um die Handhabe (3) entlang des Stellwegs zu bewegen. Der Verstellhebel (12) ist mit einer Rückstellfeder (13) vorgespannt ist, um die Handhabe (3) in die Ruheposition zu bewegen. Ein Mitnahmehebel (10) ist mit wenigstens einer Ausstellfeder (11) gekoppelt, wobei eine Krafteinwirkung auf ein Betätigungsmittel die Ausstellfeder (11) spannt. Ein Kopplungsmittel (14) koppelt den Mitnahmehebel (10) und den Verstellhebel (12) zeitweise, um eine Kraft von der Ausstellfeder (11) auf den Verstellhebel (12) zu übertragen und die Handhabe (3) der Ruheposition in die Ausstellposition zu bewegen und dabei die Rückstellfeder (13) zu spannen, und bewegt bei Aufhebung der Kopplung die Handhabe (3) durch die Rückstellkraft der Rückstellfeder (13) aus der Ausstellposition in die Ruheposition. A vehicle door handle (1) with a handle support (2) and a handle that can be gripped and that can be adjusted between a rest position and a deployed position. Handle (3) and handle support (2) are coupled via a guide mechanism (5a, 5b), an adjusting lever (12) is coupled to the guide mechanism (5a, 5b) in order to move the handle (3) along the adjustment path. The adjustment lever (12) is preloaded with a return spring (13) in order to move the handle (3) into the rest position. A driver lever (10) is coupled to at least one deployment spring (11), with a force acting on an actuating means tensioning the deployment spring (11). A coupling means (14) temporarily couples the driver lever (10) and the adjustment lever (12) in order to transmit a force from the deployment spring (11) to the adjustment lever (12) and to move the handle (3) from the rest position to the deployment position ...

Pyridine and pyrazine derivatives as protein kinase modulators

The present invention provides a compound of formula (I), and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a diseease or condition mediated by CDK9.

Pi3k.alpha. inhibitors and methods of use thereof

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.

Transportation container for nuclear power station spent fuel storage tank

The present invention provides a transportation container for a nuclear power station spent fuel storage tank including: a container body, including an inner cylinder body and an outer cylinder body sheathed outside the inner cylinder body, the inner cylinder body being provided with a guide rail; a top cover, mounted at the top of the container body by an upper flange; and a penetrating cover plate, detachably mounted at the bottom of the container body by a lower flange. An upper buffer plate is arranged between the top cover and a spent fuel storage tank in the inner cylinder body, and a lower buffer plate is arranged between the penetrating cover plate and the spent fuel storage tank in the inner cylinder body. Compared with the prior art, the transportation container for a nuclear power station spent fuel storage tank of the present invention is suitable for bearing horizontal and vertical spent fuel storage tanks, and the spent fuel storage tanks can be directly stored in the transportation container and transported to a post-treatment plant or a geological treatment facility for a long distance, to achieve recycling and retreatment of spent fuel assemblies, such that the technical problem whereby spent fuel storage tanks are not able to be directly transported for a long distance domestically and abroad is effectively solved.

Intelligent robot for back-slap sputum excretion

UITTREKSEL The present invention relates to the technical field of robotics, and is an intelligent robot capable of performing back—slap sputum excretion nursing for patients with severe respiratory diseases in place of medical workers. The invention mainly includes a mobile 5 chassis, a robot control cabinet, a laser radar, a depth camera, a mechanical arm, a vibrating percussion head, a pressure sensor, etc. When working, the robot moves autonomously to a side of the patient who needs sputum excretion nursing, the depth camera gathers characteristic information of the back of the patient and 10 plans a motion path of the mechanical arm based on the characteristic information, and then the mechanical arm conducts back—slap sputum excretion nursing operation on the back of the patient with the vibrating percussion head, and after completing the operation, the robot autonomously returns to its initial 15 position. (+ Fig. )

Pi3k-alpha inhibitors and methods of use thereof

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Ka enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Ka signaling with the compounds and compositions of the disclosure.

Automatic food feeder for aquaculture breeding

An automatic food feeder for aquatic breeding comprises a bottom plate; the lower side of the bottom plate is provided with a driving mechanism, and the driving mechanism comprises four groups of rotating shafts located on the lower side of the bottom plate; gears are sleeved on the outer sides of the two groups of rotating shafts, and a conveyor belt is connected between the two groups of gears; a plurality of groups of meshing teeth matched with the gears are uniformly provided on the inner side of the conveyor belt, and a plurality of groups of electric telescopic push blocks are uniformly arranged on the outer side of the conveyor belt; a placing rack is connected on the upper side of the bottom plate, and a control box is connected on the front part of the lower side of the placing rack.

Method and system for intracerebral hemorrhage detection and segmentation based on a multi-task fully convolutional network

Embodiments of the disclosure provide systems and methods for detecting a medical condition of a subject. The system includes a communication interface configured to receive a sequence of images acquired from the subject by an image acquisition device and an end-to-end multi-task learning model. The end-to-end multi-task learning model includes an encoder, a Convolutional Recurrent Neural Network (ConvRNN), and at least one of a decoder and a classifier. The system further includes at least one processor configured to extract feature maps from the images using the encoder, capture contextual information between adjacent images in the sequence using the ConvRNN, and detect medical condition of the subject using the classifier based on the extracted feature maps of the image slices and the contextual information or segment each image slice using the decoder to obtain a region of interest indicative of the medical condition based on the extracted feature maps.

Power battery pack safety prevention and control system for electric vehicle and control method

Method and device for establishing index

Safety prevention and control system and control method of power battery pack for electric vehicle

The present application relates to a safety prevention and control system and control method of a power battery pack for an electric vehicle. The safety prevention and control system of a power battery pack includes a signal acquisition device, a main controller, and a step-by-step prevention and control execution device. The main controller includes a fault diagnosis device, a cell thermal runaway determination device and a battery pack thermal runaway propagation determination device, which are respectively electrically connected to the step-by-step prevention and control execution device to send different control instructions to the step-by-step prevention and control execution device. The step-by-step prevention and control execution device can execute prevention and control actions of different levels according to the different control instructions sent by the fault diagnosis device, the cell thermal runaway determination device and the battery pack thermal runaway propagation determination device. The safety prevention and control system of a power battery pack for an electric vehicle can provide an active prevention and control measure and a passive prevention and control measure, and according to the actual situation of a specific accident and the prevention and control ability of the prevention and control system, accurately start a prevention and control mechanism, maximize a safety protection effect, and ensure the safety of an electric vehicle occupant.

Novel compositions and methods for cell-free dna detection

Provided herein are internal standard oligonucleotides, primers, probes and kits for the detection and quantification of cell-free DNA using multiplex quantitative real-time PCR.

Method and apparatus of processing retransmission request in distributed computing

A method and an apparatus for processing a retransmission request in distributed computing are disclosed. The method includes obtaining a retransmission request to be processed in distributed computing; determining a target copy partition corresponding to the retransmission request based on respective partition response time information of individual copy partitions; sending the retransmission request to the target copy partition. Compared with existing technologies, the present disclosure distinguishes each partition with one another based on a partition response time of the respective copy partition to determine a target copy partition corresponding to a retransmission request, thus selecting a copy with a better response time during retransmission, reducing a response time for the retransmission request and reducing an overall load of an associated cluster.

INHIBIDORES DE PI3Ka Y MÉTODOS DE USO DE LOS MISMOS

La presente divulgación se refiere a nuevos compuestos y composiciones farmacéuticas de los mismos, y a métodos para inhibir la actividad de las enzimas PI3Ka con los compuestos y composiciones de la divulgación. La presente divulgación se refiere, además, pero sin limitación, a métodos para tratar trastornos asociados con la señalización de PI3Ka con los compuestos y las composiciones de la divulgación.

PI3Kα INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Kα signaling with the compounds and compositions of the disclosure.

Methods and devices for three-dimensional image reconstruction using single-view projection image

The disclosure provides a method, device and a computer-readable medium for performing three-dimensional blood vessel reconstruction. The device includes an interface configured to receive a single-view two-dimensional image of a blood vessel of a patient, where the single-view two-dimensional image is a projection image acquired in a predetermined projection direction. The device further includes a processor configured to estimate three-dimensional information of the blood vessel from the single-view two-dimensional image using an inference model, and reconstruct a three-dimensional model of the blood vessel based on the three-dimensional information.

Novel cyclopental[c]pyrrol negative allosteric modulators of nr2b

The present disclosure provides a compound of formula (I), or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Novel cyclopenta[c]pyrrol negative allosteric modulators of nr2b

The present disclosure provides a compound of formula (I), or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Inhibidores de fosfatidilinositol 3 cinasa (pi3k) alfa y metodos de uso de los mismos.

La presente invención se refiere a nuevos compuestos y composiciones farmacéuticas de los mismos, y a métodos para inhibir la actividad de las enzimas PI3Ka con los compuestos y composiciones de la invención. La presente invención además se refiere, pero no se limita, a métodos para tratar trastornos asociados con la señalización de PI3Ka con los compuestos y composiciones de la invención.

PI3K-a INHIBITORS AND METHODS OF USE THEREOF

PI3Kα INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Kα signaling with the compounds and compositions of the disclosure.

Water changing device for aquaculture breeding

A water changing device for aquaculture breeding, comprises a breeding box. A drainage pipe is inserted into the inner wall below the breeding box; the drainage pipe has an L-shaped structure, and the horizontal side is located at the lower side of the breeding box; a sealing block is tightly inserted above the drainage pipe; a circular ring is arranged on the outer side wall of the upper end of the drainage pipe; a groove is arranged above the circular ring along the circumferential direction, and a filter screen is tightly inserted into the groove; the side wall of the drainage pipe below the breeding box is fixedly connected with a horizontal rod, and one side of the side wall below the breeding box close to the horizontal rod is fixedly provided with a threaded rod.

Aminoheteroaryl benzamides as kinase inhibitors

The present invention provides a compound of Formula (l) or a salt thereof, and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent. The compounds and compositions may be used to treat conditions responsive to an ERK112 inhibitor, and for use in the preparation of a medicament for treating these disorders, and can be used in combination with co-therapeutic agents for treating these disorders.

Data reading circuit and data reading circuit control method

A data reading circuit for reading data stored in a resistive random access memory includes a sense amplifier, a first switch, a second switch, a current trimming circuit, and a reference cell. The sense amplifier has a first input terminal coupled to a first terminal of the first switch and the data cell, and a second input terminal coupled to a first terminal of the second switch and the reference cell. A second terminal of the first switch is coupled to a second terminal of the second switch through the current trimming circuit. The current trimming circuit is configured to trim a current of the first input terminal of the sense amplifier, or trim a current of the second input terminal of the sense amplifier.

Novel cyclopenta[c]pyrrol negative allosteric modulators of nr2b

The present disclosure provides a compound of formula (I), or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides a combination of pharmacologically active agents and a pharmaceutical composition.

System and Method for Interactive Browsing

The present invention provides a system and method for achieving interactive browsing. Said system is coupled to a knowledge base and a document database, said knowledge base stores a plurality of terms and information relating to each term, and said document database stores a plurality of documents. Said system comprises term acquiring means, for acquiring terms in which a user has much interest; first extracting means, for extracting information relating to the terms in which the user has much interest, from the knowledge base; second extracting means, for extracting documents containing the terms in which the user has much interest, from the document database; a first display part in a user interface, for displaying information extracted by the first extracting means; and a second display part in the user interface, for displaying a list of the documents extracted by the second extracting means. With the present invention, one can browse both documents and information on terms in the documents in a single interface.

Prefetching RDF triple data

Query requests for RDF triples are obtained, wherein the query request(s) contain(s) at least one triple pattern; for each triple pattern, the corresponding elementary pattern is determined, and each triple pattern is converted to a weighted elementary pattern. The occurrence frequency of each elementary pattern is computed based on the weighted elementary patterns; at least one elementary pattern is chosen at least according to the occurrence frequency; and the RDF triples corresponding to the chosen at least elementary pattern are prefetched into the buffer. The corresponding apparatus is also provided. With the above method and apparatus, the frequently accessed RDF triples can be determined and prefetched into the buffer, which improves the query efficiency.

Quick detection method for pollen viability of paeonia delavayi

A quick detection method for pollen viability of Paeonia delavayi is provided, including the following steps of: (1) taking a small amount of pollen onto a glass slide and staining the pollen separately with TTC, Acetocarmine, 12_KI and 1iquid A and B; 5 repeating 3 times for each staining method, and observing 3 visual fields each time for determination; the determination method: standing for 5 min at room temperature and then observing; (2) the Paeonia delavayi pollen being capable of germinating under different medium conditions, but the germination rates of 10 different media having a significant difference (p<0.01). The medium of 150 g/L sucrose + 30 mg/L H3B03 in the present invention is suitable for in vitro culture of Paeonia delavayi pollen, and the Acetocarmine staining method can achieve the quick determination of the pollen viability of Paeonia delavayi during 15 cross breeding, thus improving the breeding efficiency. (+ Fig. 1)

System, and method for interactive browsing

The present invention provides a system and method for achieving interactive browsing. Said system is coupled to a knowledge base and a document database, said knowledge base stores a plurality of terms and information relating to each term, and said document database stores a plurality of documents. Said system comprises term acquiring means, for acquiring terms in which a user has much interest; first extracting means, for extracting information relating to the terms in which the user has much interest, from the knowledge base; second extracting means, for extracting documents containing the terms in which the user has much interest, from the document database; a first display part in a user interface, for displaying information extracted by the first extracting means; and a second display part in the user interface, for displaying a list of the documents extracted by the second extracting means. With the present invention, one can browse both documents and information on terms in the documents in a single interface.

Nuevos moduladores alostéricos negativos ciclopenta[c]pirrol de NR2B

La presente divulgación proporciona un compuesto de la fórmula (I), o una sal farmacéuticamente aceptable del mismo, un método para fabricar los compuestos de la divulgación y sus usos terapéuticos. La presente divulgación proporciona además una combinación de agentes farmacológicamente activos y una composición farmacéutica.

PI3Ka INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Kα signaling with the compounds and compositions of the disclosure.

Nuevos moduladores alostéricos negativos ciclopenta[c]pirrol de NR2B

La presente divulgación proporciona un compuesto de la fórmula (I), o una sal farmacéuticamente aceptable del mismo;(I) un método para fabricar los compuestos de la divulgación y sus usos terapéuticos. La presente divulgación proporciona además una combinación de agentes farmacológicamente activos y una composición farmacéutica.

エアバッグ装置

(57)【要約】 【課題】 エアバッグと衝撃検知システムを挿込み接続 方式に構成したエアバッグ装置を提供する。 【解決手段】 エアバッグ１２と衝撃検知システム１０ を挿込み接続方式に構成し、エアバッグ１２を自動車搭 乗者の体格に基づいて適当なサイズを選択使用でき、着 脱が簡便で使用時に安全ベルトに合わせてエアバッグ１ ２を使用者の身体の前に配置し、衝突等事故が発生した ときにエアバッグ１２が爆発膨張した際に、使用者の身 体を爆発展開の基点として前方向と横方向に膨張展開す る構成により、従来のエアバッグが使用者に向かって爆 発膨張するために発生する震動等による傷害の潜在危険 性を解消し、主動的に使用者の安全を確保できる。