VR1-BENZIMIDAZOLMODULATOREN

SUBSTITUTED TRIALZOLE AS BLOCKER OF THE SODIUM CHANNEL

MATTE ONE TO THE TWO-STAGE ODORIFEROUS SUBSTANCE DELIVERY

BIARYLSUBSTITUIERTE TRIAZOLE AS SODIUM CHANNEL BLOCKER

4D temporal data structures for visualization of alternative mission plans over time

A non-transitory computer readable medium having computer executable instructions stored thereon is provided. The computer executable instructions include a mission definition file (MDF) that includes mission data that describes alternative routes generated by at least one mission planner for a vehicle. An MDF parser extracts the mission data for the alternative routes from the MDF and maps the mission data into a temporal data structure describing the alternative routes. The temporal data includes a route list to describe the alternative routes for the vehicle and a route segment list to describe an estimated time between each of the waypoints for each segment of the route list. A waypoint list describes a latitude, a longitude, and an altitude for each of the waypoints and a mission plan constructor generates a network topology of a mission plan depicting the alternative routes for the vehicle over time.

Benzimidazole modulators of vr1

HETEROCYCLIC BENZIMIDAZOLES AS TRPM8 MODULATORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein W1, W2, W3, R1, R1a, R2, R2a, R3, V, Q, and X are defined herein.

Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

CARBOCYCLI KALIUMKANALHEMMER

Heterocyclic benzimidazoles as TRPM8 modulators

Portable shelter

A portable shelter may be provided with ground assembly, flex poles, and a cover assembly. The ground assembly may include a ground sheet or pad having rigid elements, such as metal ground poles along opposite sides. The ground poles may extend through sleeves on the ground sheet. The ends of the flex poles can be attached to fittings on the ends of the ground poles, with the flex poles flexed into an arc when the shelter is set up. The cover assembly includes a flexible cover made for example of fabric effective at blocking sunlight. Flex pole attachment devices, such as snap-on clamp fittings, may be spaced apart along opposite ends of the cover for attaching the cover onto the flex poles. Ground pole attachment devices may be spaced apart along opposite sides of the cover for attaching the cover to the ground poles.

SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold. (see formula I) ...

Portable shelter

A portable shelter may be provided with ground assembly, flex poles, and a cover assembly. The ground assembly may include a ground sheet or pad having rigid elements, such as metal ground poles along opposite sides. The ground poles may extend through sleeves on the ground sheet. The ends of the flex poles can be attached to fittings on the ends of the ground poles, with the flex poles flexed into an arc when the shelter is set up. The cover assembly includes a flexible cover made for example of fabric effective at blocking sunlight. Flex pole attachment devices, such as snap-on clamp fittings, may be spaced apart along opposite ends of the cover for attaching the cover onto the flex poles. Ground pole attachment devices may be spaced apart along opposite sides of the cover for attaching the cover to the ground poles.

FALL PROTECTION MODULAR RIGID RAIL SYSTEM

A rigid rail assembly for a fall protection system comprises a rigid rail segment and a hanger. The rail segment comprises an upper portion defining an elongate slot and a lower portion. The hanger includes a hanger body adapted to be connected to a support member and a hanger coupling member extending downwardly from said hanger body and which is adapted to be received in the rail segment slot. The rail segment lower portion has opposed elongate side walls extending downwardly and outwardly and a flange extending inwardly from each of said side walls. The flanges define a track for the wheels of a trolley.

GOAL APPARATUS

Goal apparatus comprising a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. A frame for use in the goal apparatus. A net for use in the goal apparatus comprising first, second and third edges, and a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member extending along the first, second and third edge respectively. 1. A sports net apparatus , comprising: left and right flexible posts; left and right side members; and a base member;', 'a left fitting attaching a left end of the base member to the left side member;', 'a right fitting attaching a right end of the base member to the right side member;', 'the left flexible post having an upper end and a lower end, with the lower end the left flexible post attached to the base member;', 'the right flexible post having an upper end and a lower end, with the lower end the right flexible post attached to the base member; and, 'a frame including a lower left corner attached to the front end of the left side member;', 'a lower right corner attached to the front end of the right side member;', 'an upper left corner attached to an upper end of the left flexible post;', 'an upper right corner attached to an upper end of the right flexible post; and', 'the upper ends of the left and right side flexible posts biased away from each other to maintain tension in an upper edge of the net, and also biased upwardly to maintain tension in left and right side edges of the net and with the upper left and right corners of the net in front of the left and right fittings, respectively., 'a net including2. The sports net apparatus of wherein the left and right fittings comprise corner fittings attached to a back end of the left ...

Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

VEHICLE TIRE

Portable folding shelter

A portable and foldable shelter has a canopy frame with an arm hub adjacent to a top end of a canopy pole, and a sliding collar on the pole. The canopy frame also includes a plurality of arms with each arm having an outer arm segment attached to an inner arm segment via an arm hinge joint. The arm hinge joint may include a slider movable into a locking position where the inner and outer arm segments are rigidly fixed in a straight locked-out. A flexible cover is attached to or supported on canopy frame. The portable shelter is lightweight, highly compact when folded, easy to use, and easy carry.

New or Improved Method of or/and Means for Standardising, Recording, or Matching, Different Colours or Different Shades or Hues of Colour or Colours or for Devising and Recording New Colours or New Shades of any Colour or Colours.

... 20,093. Parsons, G., Parsons, W., and Coker, A. W. Sept. 5. [Cognate Application, 30,096/13.] Colorimeters.-Apparatus for standardizing, recording, or matching colours comprises a series of colour disks X which can be mounted on a turntable A and rotated at high speed by a motor. The colour disks have radial slots x enabling any one disk to overlap another to any desired extent when two or more disks are superposed. When the disks have been adjusted to produce any desired colour, they can be fixed by a nut E which carries a loose non-rotating collar E<1>, and the amount of each colour showing can be read off by a circular scale placed over the disks. In the form shown in Fig. 9, a single colour disk is employed, and a heart shaped cam H is placed over it, a radiallydisposed measuring-device being used in this arrangement. The turntable A may have a series of holes which serve to keep the disks in contact with the table.

Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

A pushchair with engagement means for a suitcase or bag

A baby buggy, pushchair, wheelchair or the like comprises a frame which is movable between an erected position, in which the baby buggy (stroller) can be pushed or pulled along the ground on wheels 14, 21, and a collapsed position. The frame is provided with a back 22 having engagement means 25 for releasably retaining a suitcase (31, figure 7), bag or the like provided with slots (32, figure 9) adapted to receive the engagement means for releasably retaining the suitcase, bag or the like on the frame. The arrangement is such that the frame can be moved from the erected position to the collapsed position and vice versa while a suitcase, bag or the like is retained on the frame by the engagement means. The invention also extends to pushchairs, wheelchairs and other wheeled carriers such as prams.

Knock-down cabinet construction

PORTABLE SHELTER

A portable shelter may be provided with ground assembly, flex poles, and a cover assembly. The ground assembly may include a ground sheet or pad having rigid elements, such as metal ground poles along opposite sides. The ground poles may extend through sleeves on the ground sheet. The ends of the flex poles can be attached to fittings on the ends of the ground poles, with the flex poles flexed into an arc when the shelter is set up. The cover assembly includes a flexible cover made for example of fabric effective at blocking sunlight. Flex pole attachment devices, such as snap-on clamp fittings, may be spaced apart along opposite ends of the cover for attaching the cover onto the flex poles. Ground pole attachment devices may be spaced apart along opposite sides of the cover for attaching the cover to the ground poles. 1. A portable shelter comprising: a ground sheet having first and second sides and front and back ends; first and second sleeves at the first and second sides of the ground sheet, respectively; first and second ground poles extending through the first and second sleeves, respectively; first, second, third and fourth fittings, with a first fitting attached to a front end the first ground pole, a second fitting attached to front end of the second ground pole, a third fitting attached to a back end of first ground pole and a fourth fitting attached to a back end of the second ground pole; with each fitting having a first leg attached at an angle to a second leg;', 'a front flex pole having a first end attached to the first fitting and a second end attached to the second fitting, with the front flex pole flexed into a front arc;', 'a back flex pole having a first end attached to the third fitting and a second end attached to the fourth fitting, with the back flex pole flexed into a back arc; and', 'a cover assembly including a flexible cover having first and second sides and front and back ends; a plurality of front flex pole attachment devices spaced ...

4D interactive mission analytics for visualization of unmanned vehicle performance indicators

A system includes an analytics collector that receives world state data to provide status relating to a plurality of mission analytics of an unmanned vehicle or an unmanned vehicle mission planner. An asset filter filters the status from the analytics collector with respect to mission analytics of a subset of selected assets. An analytic aggregator collects the filtered status from the asset filter and generates a visual analytics file based on one or more selected analytics for the subset of selected assets. A rendering pipeline processes the visual analytics file from the analytic aggregator and generates a formatted output file describing a visualization of the plurality of mission analytics from the visual analytics file.

Benzimidazole modulators of VR1

The invention is directed to compounds of Formula (I): to pharmaceutical compositions such compounds and to methods of treatment using them.

PLUG VALVE WITH FLOATING STEM SEAL

Fall protection modular rigid rail system

A rigid rail assembly for a fall protection system comprises a rigid rail segment and a hanger. The rail segment comprises an upper portion defining an elongate slot and a lower portion. The hanger includes a hanger body adapted to be connected to a support member and a hanger coupling member extending downwardly from said hanger body and which is adapted to be received in the rail segment slot. The rail segment lower portion has opposed elongate side walls extending downwardly and outwardly and a flange extending inwardly from each of said side walls. The flanges define a track for the wheels of a trolley.

Phosphate derivatives as immunoregulatory agents

Immunoregulatory compounds are disclosed of the formula:as well as the pharmaceutically acceptable salts and hydrates thereof, are disclosed. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection.Pharmaceutical compositions and methods of use are included.

4D interactive mission analytics for visualization of unmanned vehicle performance indicators

A system includes an analytics collector that receives world state data to provide status relating to a plurality of mission analytics of an unmanned vehicle or an unmanned vehicle mission planner. An asset filter filters the status from the analytics collector with respect to mission analytics of a subset of selected assets. An analytic aggregator collects the filtered status from the asset filter and generates a visual analytics file based on one or more selected analytics for the subset of selected assets. A rendering pipeline processes the visual analytics file from the analytic aggregator and generates a formatted output file describing a visualization of the plurality of mission analytics from the visual analytics file.

Sports net and goal apparatus

A portable sports goal comprising a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. A frame for use in the goal apparatus. A net for use in the goal apparatus comprising first, second and third edges, and a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member extending along the first, second and third edge respectively. A method of providing a goal. A portable football goal.

Time interval assessment of mission plan quality dynamic asset allocation

A method includes processing one or more mission plan inputs to generate a mission definition file (MDF) that includes mission data that describes one or more plans for one or more manned or unmanned vehicles. The method includes evaluating planned tasks against defined scoring criteria specific to each task type and specific to each task to generate individual task achievement quality scores for each of the planned mission tasks. The method includes processing the MDF, the individual task quality scores, and route costs to generate a mission plan to enable evaluation and comparison of one or more mission plans. The method includes generating graphical output data from the output quality scores where the graphical output data can be configured as a mission plan evaluation chart.

A Goal and Shelter Device

A collapsible goal and shelter system is provided with a collapsible frame, a net, and a cover. The collapsible frame includes an erect configuration and a collapsed configuration. The net is operable to be attached to the frame, when the frame is in the erect configuration to thereby form a goal. The cover is operable to be attached to the frame, when the frame is in the erect configuration to thereby form a shelter. 1. A collapsible goal and shelter system , the system comprising;a collapsible frame comprising a plurality of frame members, the collapsible frame having a first, erect configuration, and a second, collapsed configuration; the frame defining an opening in the erect configuration;the system further comprising a net operable to be attached to the frame, when the frame is in the erect configuration to thereby form a goal; andthe system further comprising a cover operable to be attached to the frame, when the frame is in the erect configuration to thereby form a shelter.2. A system according to claim 1 , wherein the frame comprises two posts claim 1 , which are operable to be upwardly extending when the frame is in the erect configuration claim 1 , the posts each being formed from two or more post elements claim 1 , which are detachably connectable claim 1 , the two or more post elements being loosely secured together by an elastic member.3. A system according to claim 1 , wherein the frame comprises a crossbar claim 1 , which is operable to be substantially horizontally extending when the frame is in the erect configuration claim 1 , the crossbar being formed from two or more crossbar elements which are detachably connectable claim 1 , the two or more cross bar elements being loosely secured together by an elastic member.4. A system according to claim 3 , wherein the system comprises an elastic member and two posts and the elastic member extends through a portion of at least one post claim 3 , of the two posts and through a portion of the crossbar claim ...

GOAL APPARATUS

Goal apparatus comprising a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. A frame for use in the goal apparatus. A net for use in the goal apparatus comprising first, second and third edges, and a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member extending along the first, second and third edge respectively. 1. A sports net apparatus , comprising: left and right flexible posts; left and right side members; and a base member;', 'a left fitting attaching a left end of the base member to the left side member;', 'a right fitting attaching a right end of the base member to the right side member;', 'the left flexible post having an upper end and a lower end, with the lower end the left flexible post attached to the base member;', 'the right flexible post having an upper end and a lower end, with the lower end the right flexible post attached to the base member; and, 'a frame including a lower left corner attached to the front end of the left side member;', 'a lower right corner attached to the front end of the right side member;', 'an upper left corner attached to an upper end of the left flexible post;', 'an upper right corner attached to an upper end of the right flexible post; and', 'the upper ends of the left and right side flexible posts biased away from each other to maintain tension in an upper edge of the net, and also biased upwardly to maintain tension in left and right side edges of the net and with the upper left and right corners of the net in front of the left and right fittings, respectively., 'a net including2. The sports net apparatus of wherein the left and right fittings comprise corner fittings attached to a back end of the left ...

Spatial-temporal forecasting for predictive situational awareness

An interface includes a human machine interface (HMI) to provide a visualization of current and future states of a mission associated with one or more unmanned vehicles. A time specifier provides input to the HMI to specify a current time or a future time for the visualization of the current and future states of the mission. A prediction engine generates predictions of the current and future states of the mission for the visualization based on the current time or the future time specified by the time specifier.

Heterocyclic benzimidazoles as TRPM8 modulators

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein W1, W2, W3, R1, R1a, R2, R2a, R3, V, Q, and X are defined herein.

Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

Goal apparatus

Goal apparatus comprising a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. A frame for use in the goal apparatus. A net for use in the goal apparatus comprising first, second and third edges, and a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member extending along the first, second and third edge respectively.

Goal apparatus

Goal apparatus comprising a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. A frame for use in the goal apparatus. A net for use in the goal apparatus comprising first, second and third edges, and a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member extending along the first, second and third edge respectively.

SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold. 7. (canceled)9. (canceled)10. A compound as in claim 8 , wherein the pharmaceutically acceptable salt thereof is selected from the group consisting of sodium salt claim 8 , potassium salt and methanesulfonic acid salt.11. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of .12. A process for making a pharmaceutical composition comprising mixing a compound of and a pharmaceutically acceptable carrier.13. A method for inhibiting Icilin and CCI comprising administering to a mammal an effective amount of a compound as in .1431-. (canceled)32. A compound as in claim 4 , wherein{'sup': 1', '2', '3, 'sub': '3', 'Ris selected from the group consisting of chloro and trifluoromethyl; Ris hydrogen; Ris —OCH; Q is selected from the group consisting of 1-methyl-3-tert-butyl-4-chloro-pyrazol-5-yl and 1-methyl-3-tert-butyl-4-cyano-pyrazol-5-yl;'}or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof.3335-. (canceled) The present application claims the benefits of the filing of U.S. Provisional Application No. 61/310,870 filed Mar. 5, 2010. The complete disclosures of the aforementioned related patent applications are hereby incorporated herein by reference for all purposes.The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the TRPM8 (transient receptor ...

FALL PROTECTION MODULAR RIGID RAIL SYSTEM

A rigid rail assembly for a fall protection system comprises a rigid rail segment and a hanger. The rail segment comprises an upper portion defining an elongate slot and a lower portion. The hanger includes a hanger body adapted to be connected to a support member and a hanger coupling member extending downwardly from said hanger body and which is adapted to be received in the rail segment slot. The rail segment lower portion has opposed elongate side walls extending downwardly and outwardly and a flange extending inwardly from each of said side walls. The flanges define a track for the wheels of a trolley. 1. A rigid rail assembly for a fall protection system; the rigid rail assembly comprising a rail segment and a hanger:the rail segment comprising an upper portion and a lower portion;the rail segment upper portion defining an elongate slot comprised of an inner portion and an opening from a top surface of the rail segment into the inner portion; the slot inner portion having a width greater than the width of the opening;the lower portion comprising a horizontal member, opposed elongate side walls extending downwardly and outwardly from the horizontal member, and a flange extending inwardly from each of the side walls; the inner ends of the flanges being spaced from each other to define an opening into an area defined by the side walls, the horizontal member, and the flanges; each the flange having an upper surface defining a channel, the channels of the flanges being substantially parallel to each other; andthe hanger comprising a hanger body adapted to be connected to a support member and a hanger coupling member extending downwardly from the hanger body; the coupling member comprising a stem sized to pass through the opening of the slot in the rail segment upper portion and a footing having a width greater than the stem and sized to be slidingly received in the slot inner portion, whereby the hanger is slidably receivable in said rail segment upper portion and ...

SPATIAL-TEMPORAL FORECASTING FOR PREDICTIVE SITUATIONAL AWARENESS

An interface includes a human machine interface (HMI) to provide a visualization of current and future states of a mission associated with one or more unmanned vehicles. A time specifier provides input to the HMI to specify a current time or a future time for the visualization of the current and future states of the mission. A prediction engine generates predictions of the current and future states of the mission for the visualization based on the current time or the future time specified by the time specifier. 1. A system , comprising:one or more computers executing computer executable components, the computer executable components comprising:a state aggregator that aggregates mission plan inputs and data feeds to generate a current world state output for at least one unmanned vehicle (UxV) mission, the current world state output describes the current state of the mission plan inputs and the data feeds, the mission plan inputs describes current mission destinations and tasks to be executed by the UxV and the data feeds describe current detected events that affect the current world state of the UxV mission;a time specifier to generate a command to specify a time window to execute the current UxV mission;a prediction engine that receives the current world state output of the UxV mission from the state aggregator and generates a future world state projection for the mission plan inputs and the data feeds to predict a future time projection of the UxV mission based on a future time specified by the time specifier command; anda human machine interface (HMI) to generate a visualization of the UxV mission, the HMI generates a future world state visualization for the UxV mission based on the future world state projection from the prediction engine if the future time is specified by the time specifier command.2. The system of claim 1 , wherein the time specifier comprises a time slider graphical input to specify a current time or the future time for the visualization claim ...

Portable shelter

A portable shelter may be provided with ground assembly, flex poles, and a cover assembly. The ground assembly may include a ground sheet or pad having rigid elements, such as metal ground poles along opposite sides. The ground poles may extend through sleeves on the ground sheet. The ends of the flex poles can be attached to fittings on the ends of the ground poles, with the flex poles flexed into an arc when the shelter is set up. The cover assembly includes a flexible cover made for example of fabric effective at blocking sunlight. Flex pole attachment devices, such as snap-on clamp fittings, may be spaced apart along opposite ends of the cover for attaching the cover onto the flex poles. Ground pole attachment devices may be spaced apart along opposite sides of the cover for attaching the cover to the ground poles.

GOAL APPARATUS

Goal apparatus

Goal apparatus comprising a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. A frame for use in the goal apparatus. A net for use in the goal apparatus comprising first, second and third edges, and a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member extending along the first, second and third edge respectively.

Goal apparatus

Goal apparatus comprising a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. A frame for use in the goal apparatus. A net for use in the goal apparatus comprising first, second and third edges, and a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member extending along the first, second and third edge respectively.

Substituted aza-bicyclic imidazole derivatives useful as trpm8 receptor modulators

Heterocyclic benzimidazoles as TRPM8 modulators

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein W 1 , W 2 , W 3 , R 1 , R 1a , R 2 , R 2a , R 3 , V, Q, and X are defined herein.

GOAL APPARATUS

A goal apparatus for soccer (football) and the like has a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. 1. A goal assembly comprising:left and right side members attached to a rear base member;left and right posts attached at opposite sides of the rear base member, with the left and right posts each having a flexible section;left and right net corner poles supported on the base;a net attached to the frame, with the net having a left edge joined to a top edge at a left net corner, and a right edge joined to the top edge at a right net corner, with the left flexible post attached to the left net corner, and the right flexible post attached to the right net corner, and with the left and right net corner poles attached to the net at left and right positions behind the left and right net corners, respectively;the left and right flexible posts each held into a flexed position by the net, with the left flexible post tensioning the left edge of the net, the right flexible post tensioning the right edge of the net, and the top edge tensioned via the left and right flexible posts pulling away from each other.2. The goal apparatus of with a lower end of left and right net corner poles attached to the left and right posts claim 1 , and with the net having left and right rear net corners releasably attached to an upper end of left and right corner posts claim 1 , respectively.3. The goal apparatus of with each of the left and right posts having a rigid lower section attached to the rear base member claim 1 , and with the left and right net corner poles attached to an upper end of the rigid lower section of the left and right posts claim 1 , respectively.4. The goal apparatus of wherein the left and ...

SUBSTITUTED BENZIMDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

4D TEMPORAL DATA STRUCTURES FOR VISUALIZATION OF ALTERNATIVE MISSION PLANS OVER TIME

A non-transitory computer readable medium having computer executable instructions stored thereon is provided. The computer executable instructions include a mission definition file (MDF) that includes mission data that describes alternative routes generated by at least one mission planner for a vehicle. An MDF parser extracts the mission data for the alternative routes from the MDF and maps the mission data into a temporal data structure describing the alternative routes. The temporal data includes a route list to describe the alternative routes for the vehicle and a route segment list to describe an estimated time between each of the waypoints for each segment of the route list. A waypoint list describes a latitude, a longitude, and an altitude for each of the waypoints and a mission plan constructor generates a network topology of a mission plan depicting the alternative routes for the vehicle over time.

PORTABLE FOLDING SHELTER

A portable and foldable shelter has a canopy frame with an arm hub adjacent to a top end of a canopy pole, and a sliding collar on the pole. The canopy frame also includes a plurality of arms with each arm having an outer arm segment attached to an inner arm segment via an arm hinge joint. The arm hinge joint may include a slider movable into a locking position where the inner and outer arm segments are rigidly fixed in a straight locked-out. A flexible cover is attached to or supported on canopy frame. The portable shelter is lightweight, highly compact when folded, easy to use, and easy carry. 1. A portable shelter , comprising: a canopy pole;', 'an arm hub adjacent to a top end of the pole;', 'a slide collar on the pole;', 'a plurality of arms with each arm including: an inner arm segment having an inner end pivotally attached to the arm hub, and an outer arm segment pivotally attached to an outer end of the inner arm segment via a hinge joint;', 'with the hinge joint having an inner fitting on the inner arm segment and an outer fitting on the outer arm segment, and a collar slidable to lock the inner and outer fittings together;', 'on each one of the arms, a strut having an outer end pivotably attached to the inner arm segment of the arm, and an inner end pivotably attached to the collar; and', 'the canopy section further including a fabric cover attached to the outer arm segment of each of the arms., 'a canopy frame including2. The portable shelter of wherein the inner fitting of one or more of the hinge joints includes a bottom plate partially overlying the outer fitting.3. The portable shelter of wherein the arm hub comprises a cap covering the top end of the canopy pole.4. The portable shelter of with the canopy pole including two or more detachable pole sections.5. The portable shelter of comprising four arms with the fabric cover comprising a polygon.6. The portable shelter of further comprising an arm cap on substantially each of the outer arm segments ...

Pathways Underlying Pancreatic Tumorigenesis and an Hereditary Pancreatic Cancer Gene

There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehensive analysis of the genes altered in 24 pancreatic tumors. First, we determined the sequences of 23,781 transcripts, representing 20,583 protein-encoding genes, in DNA from these tumors. Second, we searched for homozygous deletions and amplifications using microarrays querying ˜one million single nucleotide polymorphisms in each sample. Third, we analyzed the transcriptomes of the same samples using SAGE and next-generation sequencing-by-synthesis technologies. We found that pancreatic cancers contain an average of 63 genetic alterations, of which 49 are point mutations, 8 are homozygous deletions, and 6 are amplifications. Further analyses revealed a core set of 12 regulatory processes or pathways that were each genetically altered in 70% to 100% of the samples. The data suggest that dysregulation of this core set of pathways is responsible for the major features of pancreatic tumorigenesis. 165-. (canceled)66. A method of detecting a predisposition to pancreatic cancer , comprising:detecting in a cell or tissue sample obtained from an individual an alteration in a PALB2 gene of said individual; andcorrelating said alteration with an increased risk of developing pancreatic cancer in said individual.67. The method of claim 66 , wherein said individual is identified as having pancreatic cancer claim 66 , or as a family member of a pancreatic cancer patient.68. The method of claim 66 , wherein said detecting step comprises hybridizing a nucleic acid probe or primer to a genomic DNA or cDNA.69. The method of claim 66 , wherein said detecting step comprises DNA sequencing.70. The method of claim 66 , wherein said alteration is a germline mutation that is a nonsense mutation claim 66 , a frameshift mutation claim 66 , or a large rearrangement.71. The method of claim 66 , ...

NOVEL HERBICIDES

Compounds of formula (I) are suitable for use as herbicides: wherein R is methyl, ethyl, vinyl, ethynyl or cyclopropyl, Ris hydrogen, C-Calkyl, C-Chaloalkyl, C-Ccycloalkyl, C-Calkoxy, C-Chaloalkoxy, vinyl, propenyl, ethynyl, propynyl, halogen, or optionally substituted phenyl, Ris methyl, ethyl, vinyl, ethynyl or methoxy, Rand Rare hydrogen or together form a double bond, A is C-Ccycloalkyl which is unsubstituted or substituted once or twice by C-Calkyl, C-Chaloalkyl, C-Calkoxy, C-Calkylcarbonyloxy, C-Calkenyl, ═O or ═N—R, or A is cyclohexyl substituted once, at the 4-position, by one (C-Ccycloalkyl)methoxy, C-Ccycloalkyloxy, C-Calkenyl-CH-oxy, or benzyloxy substituent, or A is decahydro-1-naphthyl or decahydro-2-naphthyl, or A is optionally substituted phenyl, and G is hydrogen or an agriculturally acceptable metal, sulfonium, ammonium or a latentiating group. 2. Compound according to claim 1 , whereinR is methyl, ethyl, vinyl, ethynyl or cyclopropyl,{'sup': '1', 'sub': 1', '6', '1', '6', '3', '7', '1', '6', '1', '6, 'Ris hydrogen, C-Calkyl, C-Chaloalkyl, C-Ccycloalkyl, C-Calkoxy, C-Chaloalkoxy, vinyl, propenyl, ethynyl, propynyl, halogen, phenyl, or phenyl substituted by alkyl, haloalkyl, alkylsulfonyl, halogen, nitro or cyano,'}{'sup': '2', 'Ris methyl, ethyl, vinyl, ethynyl or methoxy,'}{'sup': 3', '4, 'Rand Rare hydrogen or together form a double bond,'}{'sub': 3', '7', '1', '6', '1', '6', '1', '6', '1', '6', '2', '6', '1', '6', '1', '6', '3', '7', '1', '6', '1', '6', '1', '6', '1', '6, 'sup': 10', '10, 'A is C-Ccycloalkyl which is unsubstituted or substituted once or twice by C-Calkyl, C-Chaloalkyl, C-Calkoxy, C-Calkylcarbonyloxy, C-Calkenyl, ═O or ═N—R, where Ris hydroxyl, C-Calkyl, C-Chaloalkyl, C-Ccycloalkyl, C-Calkoxy, C-CalkoxyC-Calkoxy or C-Chaloalkoxy,'}or A is optionally substituted phenyl, andG is hydrogen or an agriculturally acceptable metal, sulfonium, ammonium, or latentiating group,{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'wherein the ...

GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. 1. A method of detecting presence or absence of a somatic mutation in codon 132 in isocitrate dehydrogenase 1 (IDH1) or codon 172 in isocitrate dehydrogenase 2 (IDH2) in a sample from a human subject , comprising:assaying the sample for the IDH1 or IDH2 gene or mRNA transcribed from the gene in the human subject or protein translated from the mRNA, to identify residue 132 or a codon for residue 132 of IDH1 or residue 172 or a codon for residue 172 of IDH2, wherein a mutation is identified if the residue or the codon for the residue other than arginine is identified, and wherein if the sample is from a colorectal tumor then the residue or codon for the residue is not for a cysteine at residue 132 of IDH1.2. The method of wherein IDH1 gene is assayed and the mutation is identified if a residue or a codon for a residue selected from the group consisting of Histidine claim 1 , Serine claim 1 , Cysteine claim 1 , Leucine claim 1 , and Glycine is identified in codon or residue 132 of IDH1.3. The method of wherein the IDH2 gene is assayed and a mutation is identified if a residue or a codon for a residue selected from the group consisting of Lysine claim 1 , Glycine claim 1 , and Methionine is identified in codon or residue 172 of IDH2.4. The method of wherein the somatic mutation is R132H in IDH1.5. The method of wherein the somatic mutation is R132S in IDH1.6. The method of wherein the somatic mutation is R132C in IDH1.7. The method of wherein the somatic mutation is R132L in IDH18. The method of wherein the somatic mutation is R132G ...

High pressure air cylinders for use with self-contained breathing apparatus

A self-contained breathing apparatus includes an air cylinder pressurized to about 5500 psi, wherein the air cylinder is compatible with infrastructure used in conjunction with the air cylinder. The self-contained breathing apparatus also includes a first regulator valve for reducing air pressure from the air cylinder to a predetermined level. A second regulator valve is also provided for reducing the air pressure from the predetermined level to a level suitable for use by an operator, wherein air is supplied from the second regulator valve to the operator via a mask. The self-contained breathing apparatus further includes a frame for supporting the air cylinder on the back of the operator. Other embodiments are described and claimed.

SHELVING SYSTEM

An article support, such as a shelf, is securely attachable at a plurality of locations along a generally vertical support or rail. The article support includes a support-engaging portion having one or more tabs, at least one of which is a locking tab having a forward-extending tooth that engages the vertical support, when the tab or tabs extend through slots in the support. Optionally, a biasing element urges the article away from the support to maintain secure engagement of the locking tab with the support. The resulting shelving system or article support system is resistant to accidental detachment of the article supports from the supports and permits relatively small adjustment intervals for the article supports along the supports. 1. A shelving system for storage or display of articles , said shelving system comprising:a generally vertical support defining a plurality of generally vertically-spaced slots;a shelf including an article-supporting surface and a support-engaging portion for releasably attaching said shelf to said support at said slots;said support-engaging portion of said shelf including at least one locking tab configured for insertion into said slots of said support, said at least one locking tab comprising a rearward projection having a distal end portion, a downward projection portion extending downwardly from said distal end portion, and a tooth extending forwardly from said downward projection portion; andwherein said locking tab is received in a first slot and said tooth of said locking tab is configured to engage said support at or near a second slot for securing said shelf against unintentional disengagement from said support.2. The shelving system of claim 1 , wherein said support comprises a pair of elongate support rails and said support-engaging portion of said shelf comprises a pair of said support-engaging portions for engaging respective ones of said elongate support rails.3. The shelving system of claim 1 , wherein support-engaging ...

Tyrosine Kinome

Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in −20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention. 1. A method of screening test substances for use as anti-cancer agents , comprising:contacting a test substance with a protein kinase selected from the group consisting of: NTRK3, FES, MCCK, EPHA3, NTRK2, INSRR, JAK1, PDGFRA, EPHA7, EPHA8, KDR, FGFR1, and ERBB4;testing activity of the protein kinase;identifying a test substance which inhibits the activity of the protein kinase as a potential anti-cancer agent.2. The method of wherein the protein kinase is in a cell.3. The method of wherein the protein kinase is isolated from a cell.4. The method of wherein the protein kinase is in a cell of a cancer cell line.5. The method of wherein the protein kinase is in a cell which has been modified to express the protein kinase.6. The method of wherein the protein kinase is NTRK3.7. The method of wherein the protein kinase is FES.8. The method of wherein the protein kinase is MCCK.9. The method of wherein the protein kinase is EPHA3.10. The method of wherein the protein kinase is NTRK2.11. The method of wherein the protein kinase is INSRR.12. The method of wherein the protein kinase is JAK1.13. The method of wherein the protein kinase is PDGFRA.14. The method of wherein the protein kinase is EPHA7.15. The method of wherein the protein kinase is EPHA8.16. The method of wherein the protein kinase is ERBB4.17. The method of wherein the protein kinase is FGFR1.18. The method of wherein the protein kinase ...

SYSTEM INTEGRATION

A large and massive panel is manoeuvred and supported by a work piece support which has an upper horizontal work piece support surface for receiving the panel in extended surface-to-surface contact. An array of apertures is provided in the work piece support surface, beneath same of which are provided low friction bearing elements moveable between a raised, load-bearing position in which the panel can be slid onto the work piece support and a retracted position in which the panel is left in extended surface to surface contact with the work piece support. 1. A method of manoeuvring and supporting a panel , which comprises:providing a work piece support having a generally horizontal work piece support surface for receiving said panel in extended surface to surface contact, and a plurality of relatively low friction bearing members at spaced locations across said work piece support surface, each said bearing member being movable between a raised position in which it projects above said work piece support surface and a lowered position in which it is level with or below said work piece support surface;raising at least some of said bearing members;advancing said panel generally horizontally across and over said work piece support whereby the panel is at least partially supported by said bearing members and slides relative thereto; andlowering said bearing members so that said panel is left supported in extended surface contact with said work piece support surface.2. A method of manoeuvring and supporting a panel according to claim 1 , which comprises subsequently removing said panel by:raising said bearing members to move the panel at least partially out of contact with the work piece support surface; andremoving said panel horizontally whilst at least partially supported by said bearing members.3. A work piece support apparatus arranged to be disposed generally horizontally when in use and comprising:a generally horizontal work piece support surface for receiving a ...

GENOMIC LANDSCAPES OF HUMAN BREAST AND COLORECTAL CANCERS

Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy. 1. A method of diagnosing breast cancer in a human , comprising the steps of:{'figref': {'@idref': 'DRAWINGS', 'FIG. 10'}, 'determining in a test sample relative to a normal sample of the human, a somatic mutation in a gene or its encoded cDNA or protein, said gene selected from the group consisting of those listed in (Table S4B).'}identifying the sample as breast cancer when the somatic mutation is determined.2. The method of wherein the mutation is selected from those shown in (Table S3).3. The method of wherein the test sample is a breast tissue sample or a suspected breast cancer metastasis.4. The method of wherein the normal sample is a breast tissue sample.5. A method of diagnosing colorectal cancer in a human claim 1 , comprising the steps of:{'figref': {'@idref': 'DRAWINGS', 'FIG. 9'}, 'determining in a test sample relative to a normal sample of the human, a somatic mutation in a gene or its encoded cDNA or protein, said gene selected from the group consisting of those listed in (Table S4A);'}identifying the sample as colorectal cancer when the somatic mutation is determined.6. The method of wherein ...

Medulloblastoma genes as targets for diagnosis and therapeutics

Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.

Dispenser

Dispensing devices are disclosed that include a base, a reservoir that has a volatile active, and a housing. The housing includes a horizontal component and a vertical wall extending upwardly from the horizontal component. The horizontal component and the vertical wall define an interior volume of the housing. An activator is operatively connected to the reservoir. When the activator is activated, the volatile active is released from the reservoir into the interior volume of the housing to create a first quantity of volatile active having a first emanation rate and a second quantity of volatile active having a second emanation rate. 1. A dispensing device , comprising:a base;a reservoir disposed within the base and comprising a volatile active;a housing disposed on the base, the housing comprising a horizontal component and a vertical wall extending upwardly from the horizontal component, the horizontal component and the vertical wall defining an interior volume of the housing; andan activator operatively connected to the reservoir,wherein when the activator is activated, the volatile active is released from the reservoir into the interior volume of the housing to create a first quantity of volatile active having a first emanation rate and a second quantity of volatile active having a second emanation rate.2. The dispensing device of claim 1 , wherein the reservoir comprises an aerosol container or a pump-type sprayer.3. The dispensing device of claim 1 , wherein the volatile active is selected from the group consisting of a fragrance claim 1 , insecticide claim 1 , a deodorizer claim 1 , a fungicide claim 1 , a bacteriocide claim 1 , a sanitizer claim 1 , a pet barrier claim 1 , and combinations thereof.4. The dispensing device of claim 1 , wherein the volatile active comprises an insecticide.5. The dispensing device of claim 1 , wherein at least one of the base or the housing comprises a plastic claim 1 , a polymer claim 1 , a fabric claim 1 , a nonwoven claim 1 , ...

Dispenser

A dispensing device includes a housing, a substrate having a surface and disposed within the housing, a reservoir disposed within the housing and having a volatile active, and an activator operatively connected to the reservoir. When the activator is activated, the volatile active is released from the reservoir onto the surface to create a first quantity of volatile active having a first emanation rate and a second quantity of volatile active having a second emanation rate. 1. A dispensing device , comprising:a housing;a substrate having a surface and disposed within the housing;a reservoir disposed within the housing and comprising a volatile active; andan activator operatively connected to the reservoir,wherein when the activator is activated, the volatile active is released from the reservoir onto the surface to create a first quantity of volatile active having a first emanation rate and a second quantity of volatile active having a second emanation rate.2. The dispensing device of claim 1 , wherein the first quantity of volatile active is deflected from the surface of the substrate.3. The dispensing device of claim 1 , wherein the housing comprises a plastic claim 1 , a PET non-woven substrate claim 1 , a metal claim 1 , glass claim 1 , a manufactured material claim 1 , a natural material claim 1 , a recycled material claim 1 , a reclaimed material. wood claim 1 , stone claim 1 , paper claim 1 , rock claim 1 , or combinations thereof.4. The dispensing device of claim 1 , wherein the substrate comprises a plastic claim 1 , a polymer claim 1 , a metal claim 1 , a fabric claim 1 , a nonwoven claim 1 , a cellulosic material claim 1 , glass claim 1 , and combinations thereof.5. The dispensing device of claim 4 , wherein the substrate comprises a textured surface claim 4 , a surface pattern claim 4 , a rough surface claim 4 , a smooth surface claim 4 , a channeled surface claim 4 , and combinations thereof.6. The dispensing device of claim 1 , wherein the reservoir ...

METHOD AND SYSTEM FOR DISPENSING A COMPOSITION

A dispensing system includes a substrate and a mechanism for discharging a flowable medium through the substrate. The discharge of the flowable medium through the substrate results in a visible plume of the flowable medium for at least 3 seconds. 1. A dispensing system , comprising:a substrate; anda mechanism for discharging a flowable medium through the substrate,wherein discharge of the flowable medium through the substrate results in a visible plume of the flowable medium for at least 3 seconds.2. The dispensing system of claim 1 , wherein the plume of the flowable medium is visible for at least 8 seconds.3. The dispensing system of claim 1 , wherein the plume is visible beyond a boundary of the substrate for at least 1 second.4. The dispensing system of claim 3 , wherein the plume is visible beyond the boundary of the substrate for between 1 second to 2 seconds.5. The dispensing system of claim 1 , wherein the substrate comprises a shade circumscribing the mechanism for discharging the flowable medium.6. The dispensing system of claim 5 , wherein the shade has a horizontal component and a vertical wall extending upwardly from the horizontal component claim 5 , the flowable medium being visible as a plume for at least 3 seconds within a channel of the shade.7. A dispensing system claim 5 , comprising:a substrate having a channel; anda mechanism for discharging a flowable medium into the channel, {'sup': '3', 'an uninterrupted volume of at least 300 cm, and'}, 'wherein the channel compriseswherein the discharge of the flowable medium creates a visible plume within the channel.8. The dispensing system of claim 7 , wherein the plume is visible beyond a boundary of the substrate.9. The dispensing system of claim 7 , wherein the substrate comprises:a plurality of non-woven fibers; anda median pore diameter by volume of at least 50 μm.10. The dispensing system of claim 9 , wherein the substrate comprises nylon.11. A dispensing system claim 9 , comprising:a substrate ...

High Pressure Air Cylinders for Use with Self-Contained Breathing Apparatus

A self-contained breathing apparatus includes an air cylinder pressurized to about 5500 psig, wherein the air cylinder is compatible with infrastructure used in conjunction with the air cylinder. The self-contained breathing apparatus also includes a first regulator valve for reducing air pressure from the air cylinder to a predetermined level. A second regulator valve is also provided for reducing the air pressure from the predetermined level to a level suitable for use by an operator, wherein air is supplied from the second regulator valve to the operator via a mask. The self-contained breathing apparatus further includes a frame for supporting the air cylinder on the back of the operator. Other embodiments are described and claimed. 1. A compressed gas cylinder , comprising:a single cylinder including a pressure volume portion for containing a volume of gas pressurized to a service pressure, the pressure volume portion having a length, a diameter, and a water volume;wherein the service pressure is about 5,400 psig to about 6,000 psig; andwherein the single cylinder further includes a gas transmission port for coupling to a pressure regulator assembly.2. The compressed gas cylinder of claim 1 , wherein the single cylinder has a radius of 3.27 inches or less to minimize rotational inertia on a user.3. The compressed gas cylinder of claim 1 , wherein the pressure volume portion is configured to contain about 1200 liters of free gas.4. The compressed gas cylinder of claim 1 , wherein the pressure volume portion is configured to contain about 1800 liters of free gas.5. The compressed gas cylinder of claim 1 , wherein the pressure volume portion is configured to contain about 2400 liters of free gas.6. The compressed gas cylinder of claim 1 , wherein the pressure volume portion is configured to contain about 3000 liters of free gas.7. A self-contained breathing apparatus claim 1 , comprising:a single compressed gas cylinder comprising a pressure volume portion for ...

METHOD FOR CONTINUED BOUNDING VOLUME HIERARCHY TRAVERSAL ON INTERSECTION WITHOUT SHADER INTERVENTION

A hardware-based traversal coprocessor provides acceleration of tree traversal operations searching for intersections between primitives represented in a tree data structure and a ray. The primitives may include opaque and alpha triangles used in generating a virtual scene. The hardware-based traversal coprocessor is configured to determine primitives intersected by the ray, and return intersection information to a streaming multiprocessor for further processing. The hardware-based traversal coprocessor is configured to omit reporting of one or more primitives the ray is determined to intersect. The omitted primitives include primitives which are provably capable of being omitted without a functional impact on visualizing the virtual scene. 1memory configured to store at least a portion of an acceleration data structure including a plurality of hierarchical nodes, at least one node identifying primitives of a virtual scene; and determine primitives identified in the at least one node which are intersected by a ray; and', 'omit reporting of one or more primitives the ray is determined to intersect., 'autonomous hardware circuitry operatively coupled to the memory configured to. A system including: This application is related to the following commonly-assigned US patents and patent applications, the entire contents of each of which are incorporated by reference: U.S. application Ser. No. 14/563,872 titled “Short Stack Traversal of Tree Data Structures” filed Dec. 8, 2014; U.S. Pat. No. 9,582,607 titled “Block-Based Bounding Volume Hierarchy”; U.S. Pat. No. 9,552,664 titled “Relative Encoding For A Block-Based Bounding Volume Hierarchy” as; U.S. Pat. No. 9,569,559 titled “Beam Tracing” filed Mar. 18, 2015; U.S. Pat. No. 10,025,879 titled “Tree Data Structures Based on a Plurality of Local Coordinate Systems”; U.S. application Ser. No. 14/737,343 titled “Block-Based Lossless Compression of Geometric Data” filed Jun. 11, 2015; and the following US Applications filed ...

Method for efficient grouping of cache requests for datapath scheduling

In a ray tracer, a cache for streaming workloads groups ray requests for coherent successive bounding volume hierarchy traversal operations by sending common data down an attached data path to all ray requests in the group at the same time or about the same time. Grouping the requests provides good performance with a smaller number of cache lines.

WATERTIGHT RAY TRIANGLE INTERSECTION

A hardware-based traversal coprocessor provides acceleration of tree traversal operations searching for intersections between primitives represented in a tree data structure and a ray. The primitives may include triangles used in generating a virtual scene. The hardware-based traversal coprocessor is configured to properly handle numerically challenging computations at or near edges and/or vertices of primitives and/or ensure that a single intersection is reported when a ray intersects a surface formed by primitives at or near edges and/or vertices of the primitives. 1. (canceled)2. A system including:memory that stores at least a portion of an acceleration data structure including a plurality of hierarchical nodes, at least one node identifying a primitive range of a virtual scene; and determine intersections between a ray defined in a ray coordinate space and primitives in the primitive range; and', 'when the ray is determined to intersect an edge or vertex shared by N primitives, where N>1, select less than N primitives to report based on a tie-breaking rule that compares vertex values of vertices shared by the N primitives in the ray coordinate space., 'hardware circuitry operatively coupled to the memory and configured to3. The system of claim 2 , wherein the primitives include triangles and determining intersections between the ray and the triangles includes claim 2 , for each triangle:transforming triangle vertices into the ray coordinate space;determining edge function values of post-transform triangle edges defined by transformed triangle vertices;if all edge function values are nonzero and have a same sign, identifying the triangle as being intersected by the ray; andif one or more of the edge function values is zero, determining whether the triangle is intersected based on whether another triangle shares the triangle vertices and whether one or more edge function values of the other triangle are zero.4. The system of claim 2 , wherein the hardware ...

Goal Apparatus

Goal apparatus comprising a frame, a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member. The frame presents net connection points and is configured to support each of the pliable goal members in tension between two net connection points such that the goal apparatus presents a substantially rectangular goal mouth. A frame for use in the goal apparatus. A net for use in the goal apparatus comprising first, second and third edges, and a first pliable goalpost member, a second pliable goalpost member and a pliable crossbar member extending along the first, second and third edge respectively. 1. A sports net apparatus , comprising: left and right flexible posts; left and right side members; and a base member;', 'a left fitting attaching a left end of the base member to the left side member;', 'a right fitting attaching a right end of the base member to the right side member;', 'the left flexible post having an upper end and a lower end, with the lower end the left flexible post attached to the base member;', 'the right flexible post having an upper end and a lower end, with the lower end the right flexible post attached to the base member; and, 'a frame including a lower left corner attached to the front end of the left side member;', 'a lower right corner attached to the front end of the right side member;', 'an upper left corner attached to an upper end of the left flexible post;', 'an upper right corner attached to an upper end of the right flexible post; and', 'the upper ends of the left and right side flexible posts biased away from each other to maintain tension in an upper edge of the net, and also biased upwardly to maintain tension in left and right side edges of the net and with the upper left and right corners of the net in front of the left and right fittings, respectively., 'a net including2. The sports net apparatus of wherein the left and right fittings comprise corner fittings attached to a back end of the left ...

SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR MANAGING OUT-OF-ORDER EXECUTION OF PROGRAM INSTRUCTIONS

A method, system and computer program product embodied on a computer-readable medium are provided for managing the execution of out-of-order instructions. The method includes the steps of receiving a plurality of instructions and identifying a subset of instructions in the plurality of instructions to be executed out-of-order. 1. A method , comprising:receiving a plurality of instructions; andidentifying a subset of instructions in the plurality of instructions to be executed out-of-order.2. The method of claim 1 , wherein the identifying comprises inspecting metadata associated with the instructions to determine whether the instructions may be executed out-of-order.3. The method of claim 2 , wherein the metadata associated with instructions to be executed out-of-order specifies a queue.4. The method of claim 3 , wherein the metadata includes an identifier of the queue.5. The method of claim 3 , further comprising adding the subset of instructions to the queue.6. The method of claim 2 , wherein the metadata is embedded within the instructions.7. The method of claim 1 , wherein the subset of instructions to be executed out-of-order include arithmetic instructions.8. The method of claim 1 , further comprising enabling hazard protection for input registers associated with an instruction when at least one of the instructions to be executed out-of-order is dispatched.9. The method of claim 9 , further comprising disabling hazard protection for the input registers associated with the instruction when the instruction completes execution.10. A non-transitory computer-readable storage medium storing instructions that claim 9 , when executed by a processor claim 9 , cause the processor to perform steps comprising:receiving a plurality of instructions; andidentifying a subset of instructions in the plurality of instructions to be executed out-of-order.11. The computer-readable storage medium of claim 10 , wherein the identifying comprises inspecting metadata associated with ...

Diagnostic Method Using PALB2/US

The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.

HIGH PRESSURE AIR CYLINDERS FOR USE WITH SELF-CONTAINED BREATHING APPARATUS

A self-contained breathing apparatus includes an air cylinder pressurized to about 5500 psi, wherein the air cylinder is compatible with infrastructure used in conjunction with the air cylinder. The self-contained breathing apparatus also includes a first regulator valve for reducing air pressure from the air cylinder to a predetermined level. A second regulator valve is also provided for reducing the air pressure from the predetermined level to a level suitable for use by an operator, wherein air is supplied from the second regulator valve to the operator via a mask. The self-contained breathing apparatus further includes a frame for supporting the air cylinder on the back of the operator. Other embodiments are described and claimed. 2. The compressed gas cylinder of wherein the first pressure is about 5400 psi to about 5500 psi.3. The compressed gas cylinder of claim 1 , wherein the first pressure is about 5500 psi.4. The compressed gas cylinder of claim 1 , wherein the first pressure is about 5500 psi to about 5600 psi.5. The compressed gas cylinder of claim 1 , wherein the water volume is about 349 cubic inches.6. The compressed gas cylinder of claim 1 , wherein the pressure volume portion is configured to contain about 1200 liters of free air.7. The compressed gas cylinder of claim 6 , wherein the cylinder has a weight from about 5.7 pounds to about 6.6 pounds.8. The compressed gas cylinder of claim 7 , wherein the length of the pressure volume portion is about 14.8 inches to about 17.3 inches claim 7 , and the diameter of the pressure volume portion is about 4.3 inches to about 4.7 inches.9. The compressed gas cylinder of claim 1 , wherein the pressure volume portion is configured to contain about 1800 liters of free air.10. The compressed gas cylinder of claim 9 , wherein the weight is about 7.8 to about 9.0 pounds.11. The compressed gas cylinder of claim 10 , wherein the length of the pressure volume portion is about 16.9 inches to about 19.5 inches claim 10 ...

TORSIONAL MODE TIRE WEAR STATE ESTIMATION SYSTEM AND METHOD

A tire wear state estimation system includes a tire pressure measuring device affixed to a vehicle tire for measuring tire inflation pressure and generating tire inflation pressure data; tire torsional mode measuring means for measuring tire torsional mode frequency and generating tire torsional mode frequency data; and tire identification means for generating tire-specific torsional mode coefficients using tire-specific identification data. A tire wear estimation is made based upon the tire inflation pressure data, the torsional mode frequency data, and the tire identification derived torsional mode coefficients. 1. A tire wear state estimation system comprising:at least one tire supporting a vehicle;tire pressure measuring means affixed to the one tire for measuring tire inflation pressure and generating tire inflation pressure data;tire torsional mode measuring means for measuring tire torsional mode frequency and generating tire torsional mode frequency data;tire identification means for generating tire-specific frequency mode coefficients using tire-specific identification data; andtire wear estimation means for calculating an estimation of a tire wear state based upon the tire inflation pressure data, the torsional mode frequency data, and the tire-specific frequency mode coefficients.2. The tire wear state estimation system of claim 1 , wherein the tire pressure measuring means comprises a tire-mounted pressure measuring device operative to measure by a pressure sensor a tire cavity pressure and transmit the tire inflation pressure data from the tire cavity pressure measurement.3. The tire wear state estimation system of claim 2 , wherein the tire-specific identification data is stored within and accessible from the tire-mounted pressure measuring device.4. The tire wear state estimation system of claim 3 , wherein the tire-specific torsional frequency mode coefficients are generated using a wheel speed signal or a hub mounted accelerometer sensor signal.5. ...

METHOD FOR CONTINUED BOUNDING VOLUME HIERARCHY TRAVERSAL ON INTERSECTION WITHOUT SHADER INTERVENTION

A hardware-based traversal coprocessor provides acceleration of tree traversal operations searching for intersections between primitives represented in a tree data structure and a ray. The primitives may include opaque and alpha triangles used in generating a virtual scene. The hardware-based traversal coprocessor is configured to determine primitives intersected by the ray, and return intersection information to a streaming multiprocessor for further processing. The hardware-based traversal coprocessor is configured to omit reporting of one or more primitives the ray is determined to intersect. The omitted primitives include primitives which are provably capable of being omitted without a functional impact on visualizing the virtual scene. 1memory configured to store at least a portion of an acceleration data structure including a plurality of hierarchical nodes, at least one node identifying primitives of a virtual scene; and determine primitives identified in the at least one node which are intersected by a ray; and', 'omit reporting of one or more primitives the ray is determined to intersect., 'autonomous hardware circuitry operatively coupled to the memory configured to. A system including: This application is related to the following commonly-assigned US patents and patent applications, the entire contents of each of which are incorporated by reference: U.S. application Ser. No. 14/563,872 titled “Short Stack Traversal of Tree Data Structures” filed Dec. 8, 2014; U.S. Pat. No. 9,582,607 titled “Block-Based Bounding Volume Hierarchy”; U.S. Pat. No. 9,552,664 titled “Relative Encoding For A Block-Based Bounding Volume Hierarchy” as; U.S. Pat. No. 9,569,559 titled “Beam Tracing” filed Mar. 18, 2015; U.S. Pat. No. 10,025,879 titled “Tree Data Structures Based on a Plurality of Local Coordinate Systems”; U.S. application Ser. No. 14/737,343 titled “Block-Based Lossless Compression of Geometric Data” filed Jun. 11, 2015; and the following US applications filed ...

USING IMPORTANCE RESAMPLING TO REDUCE THE MEMORY INCOHERENCE OF LIGHT SAMPLING

Devices, systems, and techniques to incorporate lighting effects into computer-generated graphics. In at least one embodiment, a virtual scene comprising a plurality of lights is rendered by randomly sampling a set of lights from among the plurality of lights prior to rendering a frame of graphics. A subset of the set of lights is selected and used to render pixels within one or more portions of the frame. 1. A system , comprising:at least one processor;at least one memory comprising instructions that, in response to execution by the at least one processor, cause the system to at least:select a set of lights from among a plurality of lights associated with a virtual scene, the set of lights selected based, at least in part, on a first one or more random factors;select, based at least in part on a second one or more random factors, a subset of lights from the set of lights, the subset of lights to be used to generate a frame of graphics, wherein the subset of lights is selected so that data indicative of the subset has a total size less than memory predicted to be available in a processor cache; andrender a pixel of the frame of graphics based, at least in part, on the subset of lights.2. The system of claim 1 , the at least one memory comprising further instructions that claim 1 , in response to execution by the at least one processor claim 1 , cause the system to at least:select an additional set of lights to use to generate an additional frame of graphics, the additional set of lights selected from among the plurality of lights associated with the virtual scene.3. The system of claim 1 , the at least one memory comprising further instructions that claim 1 , in response to execution by the at least one processor claim 1 , cause the system to at least:render a second pixel of the frame of graphics using a second subset of lights selected from the set of lights.4. The system of claim 1 , wherein the pixel is one of a plurality of pixels in a first tile of the frame ...

Consensus Coding Sequences of Human Breast and Colorectal Cancers

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring. 1{'figref': {'@idref': 'DRAWINGS', 'FIG. 13'}, 'determining in a test sample relative to a normal sample of the human, a somatic mutation in a gene or its encoded cDNA or protein, said gene selected from the group consisting of those listed in (Table S5);'}identifying the sample as breast cancer when the somatic mutation is determined.. A method of diagnosing breast cancer in a human, comprising the steps of: This application is a continuation of U.S. patent application Ser. No. 15/413,903 filed Jan. 24, 2017; which is a divisional of U.S. patent application Ser. No. 14/224,102 filed Mar. 25, 2014, which is a divisional application of U.S. patent application Ser. No. 12/377,073 filed Jul. 12, 2010, which is a 371 U.S. National Application of PCT/US2007/017866 filed Aug. 13, 2007, which claims priority to U.S. Provisional Application No. 60/842,363 filed Sep. 6, 2006 and U.S. Provisional Application No. 60/836,944 filed Aug. 11, 2006, the entire contents of which are hereby incorporated by reference.This invention was made with government support under Grant Nos. CA121113, CA43460, CA43460, CA57345, CA62924, GM07309, RR017698, P30-CA43703, AND CA109274 awarded by National Institute of Health and DAMD17-03-1-0241 awarded by Department of Defense. The government has certain rights in ...

ROBUST, EFFICIENT MULTIPROCESSOR-COPROCESSOR INTERFACE

Systems and methods for an efficient and robust multiprocessor-coprocessor interface that may be used between a streaming multiprocessor and an acceleration coprocessor in a GPU are provided. According to an example implementation, in order to perform an acceleration of a particular operation using the coprocessor, the multiprocessor: issues a series of write instructions to write input data for the operation into coprocessor-accessible storage locations, issues an operation instruction to cause the coprocessor to execute the particular operation; and then issues a series of read instructions to read result data of the operation from coprocessor-accessible storage locations to multiprocessor-accessible storage locations. 1. A method performed by a multiprocessor to execute an operation on a communicatively coupled coprocessor , the method comprising:establishing a connection to the coprocessor;issuing a plurality of write instructions to write input data for the operation into coprocessor-accessible storage locations;issuing an operation instruction to cause the coprocessor to execute the operation using said input data;issuing a plurality of read instructions to read result data of the operation from coprocessor-accessible storage locations to multiprocessor-accessible storage locations; andclosing the connection.2. The method according to claim 1 , further comprising blocking until said establishing a connection completes.3. The method according to claim 2 , wherein said blocking until establishing a connection completes is the only blocking instruction between said establishing and said closing.4. The method according to claim 2 , further comprising:after the closing, waiting on said result data to be written to one or more of said multiprocessor-accessible storage locations; andfollowing said waiting, consuming said result data in the multiprocessor-accessible storage locations.5. The method according to claim 4 , further comprising one or more other ...

Method for efficient grouping of cache requests for datapath scheduling

In a ray tracer, a cache for streaming workloads groups ray requests for coherent successive bounding volume hierarchy traversal operations by sending common data down an attached data path to all ray requests in the group at the same time or about the same time. Grouping the requests provides good performance with a smaller number of cache lines.

METHOD FOR CONTINUED BOUNDING VOLUME HIERARCHY TRAVERSAL ON INTERSECTION WITHOUT SHADER INTERVENTION

A hardware-based traversal coprocessor provides acceleration of tree traversal operations searching for intersections between primitives represented in a tree data structure and a ray. The primitives may include opaque and alpha triangles used in generating a virtual scene. The hardware-based traversal coprocessor is configured to determine primitives intersected by the ray, and return intersection information to a streaming multiprocessor for further processing. The hardware-based traversal coprocessor is configured to omit reporting of one or more primitives the ray is determined to intersect. The omitted primitives include primitives which are provably capable of being omitted without a functional impact on visualizing the virtual scene. 1. A system that develops visualization of a virtual scene , comprising:memory configured to store at least a portion of an acceleration data structure, wherein the acceleration data structure includes a plurality of hierarchical nodes, wherein at least one of said hierarchical nodes identifies a plurality of primitives of the virtual scene; and receive information about a ray; and', traverse the acceleration data structure;', 'determine a plurality of intersected primitives, wherein each intersected primitive is a primitive in the plurality of primitives that is intersected by a ray;', 'determine at least one primitive among the plurality of intersected primitives that will not affect visualization of the virtual scene; and', 'report two or more of the intersected primitives while omitting to report the at least one primitive that is determined will not affect visualization of the virtual scene., 'in response to receiving the ray information,'}], 'circuitry operatively coupled to the memory configured to2. The system of claim 1 , wherein the circuitry comprises a coprocessor.3. The system of claim 1 , wherein the plurality of intersected primitives include one or more alpha primitives and one or more opaque primitives claim 1 , ...

WATERTIGHT RAY TRIANGLE INTERSECTION

A hardware-based traversal coprocessor provides acceleration of tree traversal operations searching for intersections between primitives represented in a tree data structure and a ray. The primitives may include triangles used in generating a virtual scene. The hardware-based traversal coprocessor is configured to properly handle numerically challenging computations at or near edges and/or vertices of primitives and/or ensure that a single intersection is reported when a ray intersects a surface formed by primitives at or near edges and/or vertices of the primitives. 1. A device including hardware circuitry configured to:receive a ray and a plurality of primitives;determine, using an arithmetic unit having a predetermined precision, whether the ray intersects an edge or vertex of the primitives; andwhen the ray is determined to intersect an edge or vertex shared by two or more primitives, identify a single one of the two or more primitives sharing the edge or vertex as being intersected by the ray without using arithmetic that is higher than said predetermined precision.2. The device of claim 1 , wherein the hardware circuitry includes a fused floating point operation unit configured to combine multiple floating-point arithmetic operations used to determine whether the ray intersects the primitives.3. The device of claim 2 , wherein the fused floating point operation unit is configured to perform arithmetic operations using single precision floating-point numbers.4. The device of claim 2 , wherein the fused floating point operation unit is configured to perform arithmetic operations with expanded 10-bit exponent range.5. The device of claim 1 , wherein the primitives are triangles and determining whether a triangle is intersected by the ray includes:determining a permutation that takes a largest-magnitude component of ray direction vector to a z component of the ray;applying the permutation to a ray origin vector, a ray direction vector, and triangle vertices; ...

QUERY-SPECIFIC BEHAVIORAL MODIFICATION OF TREE TRAVERSAL

Methods and systems are described in some examples for changing the traversal of an acceleration data structure in a highly dynamic query-specific manner, with each query specifying test parameters, a test opcode and a mapping of test results to actions. In an example ray tracing implementation, traversal of a bounding volume hierarchy by a ray is performed with the default behavior of the traversal being changed in accordance with results of a test performed using the test opcode and test parameters specified in the ray data structure and another test parameter specified in a node of the bounding volume hierarchy. In an example implementation a traversal coprocessor is configured to perform the traversal of the bounding volume hierarchy. 1. A method of ray tracing , comprising:accessing ray data corresponding to a ray and an acceleration data structure corresponding to a scene;traversing the acceleration data structure in accordance with the ray data;during the traversing, performing for at least one node in the acceleration data structure an intersection test based upon geometric attributes of the ray and the acceleration data structure and an auxiliary ray operation test;based on results of the intersection test and the auxiliary ray operation test, during the traversing, performing at least one of changing a state of the traversing and selecting an output data corresponding to one or more nodes of the acceleration data structure intersected by the ray; andproviding output data from the traversing to a rendering process for rendering at least a portion of the scene to a display.2. The method according to claim 1 , wherein the performing an intersection test and an auxiliary ray operation test comprises selecting the ray operation test based upon an opcode in the ray data.3. The method according to claim 2 , wherein the performing an intersection test and an auxiliary ray operation test further comprises performing the selected ray operation test based upon at ...

METHOD FOR HANDLING OF OUT-OF-ORDER OPAQUE AND ALPHA RAY/PRIMITIVE INTERSECTIONS

A hardware-based traversal coprocessor provides acceleration of tree traversal operations searching for intersections between primitives represented in a tree data structure and a ray. The primitives may include opaque and alpha triangles used in generating a virtual scene. The hardware-based traversal coprocessor is configured to determine primitives intersected by the ray, and return intersection information to a streaming multiprocessor for further processing. The hardware-based traversal coprocessor is configured to provide a deterministic result of intersected triangles regardless of the order that the memory subsystem returns triangle range blocks for processing, while opportunistically eliminating alpha intersections that lie further along the length of the ray than closer opaque intersections. 1. A system including:memory configured to store at least a portion of an acceleration data structure including a plurality of hierarchical nodes, at least one node identifying primitives of a virtual scene; and determine, in the order the primitives identified in the at least one node are received from memory, primitives which are intersected by a ray; and', 'report at least a portion of the primitives the ray is determined to intersect in a memory order the primitives are stored in the memory., 'autonomous hardware circuitry operatively coupled to the memory configured to2. The system of claim 1 , wherein the autonomous hardware circuitry comprises a coprocessor.3. The system of claim 1 , wherein the memory is configured to store a plurality of cache line sized blocks each including a different set of primitives identified in the at least one node claim 1 , and the blocks are received by the hardware circuitry out of order in which they are stored in the memory.4. The system of claim 1 , wherein the hardware circuitry is further configured to omit reporting of one or more primitives the ray is determined to intersect.5. The system of claim 4 , wherein the omitted one ...

METHOD FOR FORWARD PROGRESS AND PROGRAMMABLE TIMEOUTS OF TREE TRAVERSAL MECHANISMS IN HARDWARE

In a ray tracer, to prevent any long-running query from hanging the graphics processing unit, a traversal coprocessor provides a preemption mechanism that will allow rays to stop processing or time out early. The example non-limiting implementations described herein provide such a preemption mechanism, including a forward progress guarantee, and additional programmable timeout options that can be time or cycle based. Those programmable options provide a means for quality of service timing guarantees for applications such as virtual reality (VR) that have strict timing requirements. 1. An interruptible coprocessor providing a forward progress guarantee comprising:bounding volume hierarchy traversal circuitry; andcontrol circuitry operatively coupled to the bounding volume hierarchy traversal circuitry and connected to receive a preemption signal, the control circuitry ensuring that bounding volume hierarchy traversal circuitry makes forward progress before stopping further forward progress in response to assertion of the preemption signal.2. The interruptible coprocessor of wherein the interruptible coprocessor is stateless and the control circuitry is stack-based.3. The interruptible coprocessor of wherein the interruptible coprocessor confirms forward progress by ensuring that at least one operation that changes a stack has or will be performed.4. The interruptible coprocessor of wherein the interruptible coprocessor uses a bit array to track traversal.5. The interruptible coprocessor of wherein the control circuitry uses an inference that forward progress has occurred.6. The interruptible coprocessor of wherein the control circuitry uses an inference that a stack modification will take place.7. The interruptible coprocessor of wherein the control circuitry is configured to test that forward progress of a certain type has occurred.8. The interruptible coprocessor of wherein the certain type comprises traversal of at least one leaf node of the bounding volume ...

METHOD FOR FORWARD PROGRESS AND PROGRAMMABLE TIMEOUTS OF TREE TRAVERSAL MECHANISMS IN HARDWARE

In a ray tracer, to prevent any long-running query from hanging the graphics processing unit, a traversal coprocessor provides a preemption mechanism that will allow rays to stop processing or time out early. The example non-limiting implementations described herein provide such a preemption mechanism, including a forward progress guarantee, and additional programmable timeout options that can be time or cycle based. Those programmable options provide a means for quality of service timing guarantees for applications such as virtual reality (VR) that have strict timing requirements. 1. An interruptible coprocessor providing a forward progress guarantee comprising:bounding volume hierarchy traversal circuitry; andcontrol circuitry operatively coupled to the bounding volume hierarchy traversal circuitry and connected to receive a preemption signal, the control circuitry ensuring that bounding volume hierarchy traversal circuitry makes forward progress before stopping further forward progress in response to assertion of the preemption signal.2. The interruptible coprocessor of wherein the interruptible coprocessor is stateless and the control circuitry is stack-based.3. The interruptible coprocessor of wherein the interruptible coprocessor confirms forward progress by ensuring that at least one operation that changes a stack has or will be performed.4. The interruptible coprocessor of wherein the interruptible coprocessor uses a bit array to track traversal.5. The interruptible coprocessor of wherein the control circuitry uses an inference that forward progress has occurred.6. The interruptible coprocessor of wherein the control circuitry uses an inference that a stack modification will take place.7. The interruptible coprocessor of wherein the control circuitry is configured to test that forward progress of a certain type has occurred.8. The interruptible coprocessor of wherein the certain type comprises traversal of at least one leaf node of the bounding volume ...

DISPENSER

A dispensing device includes a housing, a substrate having a surface and disposed within the housing, a reservoir disposed within the housing and having a volatile active, and an activator operatively connected to the reservoir. When the activator is activated, the volatile active is released from the reservoir onto the surface to create a first quantity of volatile active having a first emanation rate and a second quantity of volatile active having a second emanation rate. 1. A dispensing device , comprising:a housing;a substrate having a surface and disposed within the housing;a reservoir disposed within the housing and comprising a volatile active; andan activator operatively connected to the reservoir,wherein when the activator is activated, the volatile active is released from the reservoir onto the surface to create a first quantity of volatile active having a first emanation rate and a second quantity of volatile active having a second emanation rate.2. The dispensing device of claim 1 , wherein the first quantity of volatile active is deflected from the surface of the substrate.3. The dispensing device of claim 1 , wherein the substrate comprises a plastic claim 1 , a polymer claim 1 , a metal claim 1 , a fabric claim 1 , a nonwoven claim 1 , a cellulosic material claim 1 , glass claim 1 , and combinations thereof.4. The dispensing device of claim 1 , wherein the reservoir comprises an aerosol container.5. The dispensing device of claim 1 , wherein the volatile active is chosen from the group consisting of a fragrance claim 1 , insecticide claim 1 , a deodorizer claim 1 , a fungicide claim 1 , a bacteriocide claim 1 , a sanitizer claim 1 , a pet barrier claim 1 , and combinations thereof.6. The dispensing device of claim 1 , wherein the volatile active is an insecticide.7. The dispensing device of claim 1 , wherein the activator comprises a manual push button.8. A dispensing device claim 1 , comprising:a housing comprising a surface;a reservoir comprising a ...

Genetic Alterations in Isocitrate Dehydrogenase and Other Genes in Malignant Glioma

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

TIRE SLIP ANGLE ESTIMATION SYSTEM AND METHOD

A slip angle estimation includes a tire having one or more first and second strain sensor(s) affixed to opposite respective first and second tire sidewalls. The sensors measure a tire strain in their respective sidewalls and generate a sidewall strain signal indicative of strain present within the tire sidewalls. A slip angle estimation is made by estimating the difference in the signal slope of the sensors in the opposite sidewalls. A load estimation is further made for the tire from the inner and outer sidewall strain signals and the load estimation is used in the slip angle estimation. 1. A slip angle estimation system for estimating a vehicle tire slip angle comprising:at least one tire supporting a vehicle;first and second strain sensing means affixed to opposite respective first and second tire sidewalls of the tire to operably measure a tire strain in the respective first and second sidewalls, the first and the second strain sensing means each generating a sidewall strain signal indicative of strain present within the respective tire sidewalls;tire slip angle estimation means for calculating a tire slip angle based upon a comparison of the sidewall strain signals from the first and the second strain sensing means.2. The slip angle estimation system of claim 1 , wherein the first and the second sidewall strain sensing means each comprises a strain sensing device mounted respectively to an axially inward surface of the first and the second tire sidewalls.3. The slip angle estimation system of claim 2 , wherein the sidewall strain signals from the first and the second strain sensing devices each comprise a signal curve operably representing sidewall deflection of the respective first and the second sidewalls.4. The slip angle estimation system of claim 3 , wherein the slip angle estimation means comprises signal peak detection means for detecting a peak in the sidewall strain signal curves from the first and the second strain sensing devices; extraction means ...

METHOD FOR FORWARD PROGRESS AND PROGRAMMABLE TIMEOUTS OF TREE TRAVERSAL MECHANISMS IN HARDWARE

In a ray tracer, to prevent any long-running query from hanging the graphics processing unit, a traversal coprocessor provides a preemption mechanism that will allow rays to stop processing or time out early. The example non-limiting implementations described herein provide such a preemption mechanism, including a forward progress guarantee, and additional programmable timeout options that can be time or cycle based. Those programmable options provide a means for quality of service timing guarantees for applications such as virtual reality (VR) that have strict timing requirements. 1bounding volume hierarchy traversal circuitry; andcontrol circuitry operatively coupled to the bounding volume hierarchy traversal circuitry and connected to receive a preemption signal, the control circuitry ensuring that bounding volume hierarchy traversal circuitry makes forward progress before stopping further forward progress in response to assertion of the preemption signal.. An interruptible coprocessor providing a forward progress guarantee comprising: This application is related to the following commonly-assigned US patents and patent applications, the entire contents of each of which are incorporated by reference: U.S. application Ser. No. 14/563,872 titled “Short Stack Traversal of Tree Data Structures” filed Dec. 8, 2014; U.S. Pat. No. 9,582,607 titled “Block-Based Bounding Volume Hierarchy”; U.S. Pat. No. 9,552,664 titled “Relative Encoding For A Block-Based Bounding Volume Hierarchy” as; U.S. Pat. No. 9,569,559 titled “Beam Tracing” filed Mar. 18, 2015; U.S. Pat. No. 10,025,879 titled “Tree Data Structures Based on a Plurality of Local Coordinate Systems”; U.S. application Ser. No. 14/737,343 titled “Block-Based Lossless Compression of Geometric Data” filed Jun. 11, 2015; and the following US applications filed concurrently herewith:The present technology relates to computer graphics, and more particularly to ray tracers. More particularly, the technology relates to ...

GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. 1. An isolated polynucleotide comprising at least 18 but less than 600 contiguous nucleotide residues of a coding sequence of a human IDH1 or IDH2 protein found in a human tumor , said at least 18 contiguous nucleic acid residues comprising:nucleotides 394 and/or 395 of IDH1, wherein said nucleotides 394 and/or 395 are not C and/or G, respectively;nucleotide 515 of IDH2, wherein said nucleotide 515 is not a G.2. The isolated polynucleotide of wherein the coding sequence is of a human IDH1 protein and the nucleotide 394 is selected from the group consisting of T claim 1 , A claim 1 , and G or nucleotide 395 is selected from the group consisting of A and T.3. The isolated polynucleotide of wherein the coding sequence is of a human IDH2 protein and the nucleotide 515 is selected from the group consisting of T and A or nucleotide 514 is a G.4. The isolated polynucleotide of which is labeled with a detectable label.5. The isolated polynucleotide of wherein nucleotide 394 is T.6. The isolated polynucleotide of wherein nucleotide 394 is A.7. The isolated polynucleotide of wherein nucleotide 394 is G.8. The isolated polynucleotide of wherein nucleotide 395 is A.9. The isolated polynucleotide of wherein nucleotide 395 is T.10. The isolated polynucleotide of wherein nucleotide 515 is T.11. The isolated polynucleotide of wherein nucleotide 515 is A.12. The isolated polynucleotide of wherein nucleotide 514 is a G. This application was made using funds from the United States government. Therefore the U.S. government retains certain rights in ...

GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. 1. (canceled)2. A method of treating a mutant isocitrate dehydrogenase 1 (IDH1) enzyme-associated cancer in a subject comprising:detecting the presence of an isocitrate dehydrogenase 1 (IDH1) mutation in a nucleic acid present in a sample obtained from the subject; andadministering to the subject an anti-cancer agent selected from the group consisting of a chemotherapeutic agent and a biological agent to treat the tumor, wherein the anti-cancer agent inhibits the activity of the mutant IDH1 enzyme.3. The method of claim 2 , wherein the IDH1 mutation is present in a mutant codon that corresponds to a wild type codon that encodes amino acid 132 in the wild type IDH1 polypeptide of SEQ ID NO: 130.4. The method of claim 3 , wherein the mutant codon that includes the IDH1 mutation encodes an amino acid selected from the group consisting of: histidine (H) claim 3 , cysteine (C) claim 3 , serine (S) claim 3 , leucine (L) claim 3 , and glycine (G).5. The method of claim 2 , wherein the presence of an IDH1 mutation in the sample is detected using an amplification primer claim 2 , a hybridization probe claim 2 , or both.6. The method of claim 5 , wherein:the amplification primer comprises at least 10 but fewer than 600 contiguous nucleotide residues of a coding sequence of a IDH1 protein found in a tumor of the subject, or its complement, the at least 10 contiguous nucleic acid residues comprising:a first nucleotide that is present at a position in a mutant codon that corresponds to a wild type codon that encodes amino acid 132 in the wild ...

UNMANNED AERIAL VEHICLE FOR SITUATIONAL AWARENESS TO FIRST RESPONDERS AND ALARM INVESTIGATION

A device, and method, for situational awareness of an emergency scene for first responders uses an unmanned aerial vehicle equipped with a sensor package in populated or otherwise restricted areas. The unmanned aerial vehicle is assigned to a control center for a designated incident while automatically tasking the unmanned aerial vehicle with the initiation of the incident response to autonomously proceed to the incident prior the control center taking active control of the unmanned aerial vehicle. 1. An emergency response unmanned aerial vehicle protocol comprising one or more unmanned aerial vehicles having a pre-set flight paths, the one or more unmanned aerial vehicles initiated with a fire station activation for assignment of the unmanned aerial vehicles to a designated fire station and emergency event. The present disclosure relates generally to Unmanned Aerial Vehicles (UAV) use by first responders and alarm investigation for situational awareness.A device, and method, for situational awareness of an emergency scene for first responders uses a UAV equipped with a sensor package in populated or otherwise restricted areas.Referring to the figures, the invention includes an Unmanned Aerial Vehicle (UAV) equipped with a sensor package that can be used by first responders for enhancing their situational awareness on an emergency scene , particularly in urban or other densely populated areas.As seen in , the UAV is launched from a central location , such as a storage area, firehouse, police station, or other like controllable and localized location, to minimize flight time to a destination. Referring to , the launch and operation of the UAV can be initiated automatically, remotely, or on scene with the UAV at its storage location. Launch of the UAV is preferably initiated by the receipt of a dispatch call , which may be initiated as an emergency call for fire, medical or police action, e.g., 911 call, which is routed to an emergency team operator. With receipt and ...

TIRE WEAR COMPENSATED LOAD ESTIMATION SYSTEM AND METHOD

A system and method of estimating a load bearing on a vehicle tire includes an inflation pressure measuring sensor for measuring an inflation pressure level within a tire cavity; a contact patch length sensor measuring the rolling contact patch length of the tire; a tire rolling speed sensor measuring a rolling speed of the tire; and a tire wear state estimation calculator estimating a tire wear state of a tread of the tire. An artificial neural network estimates a tire load from the contact patch length, the inflation pressure level, and the tire rolling speed by utilizing as a compensation factor input the estimated tire wear state. 1. A system of estimating a load bearing on a vehicle tire , comprising:a vehicle tire having a tire cavity and supporting a load;an inflation pressure measuring sensor attached to the tire for measuring an inflation pressure level within the tire cavity;a contact patch length sensor attached to the tire for measuring the contact patch length of the tire rolling against a ground surface carrying a tire load;a tire rolling speed sensor mounted to the vehicle for measuring a rolling speed of the tire;a tire wear state estimation calculator for estimating a tire wear state of a tread of the tire; anda tire load calculator for estimating a tire load from the contact patch length, the inflation pressure level, and the tire rolling speed; the tire load calculator in the estimation of the tire load operably utilizing as a compensation factor input the estimated tire wear state.2. The system of claim 1 , wherein further comprising a hub acceleration sensor for measuring a hub acceleration of a hub supporting the vehicle tire; and wherein the tire wear state estimation calculator estimating the tire wear state from the hub acceleration.3. The system of claim 2 , wherein the tire load calculator comprises an artificial neural network-based signal processor receiving as inputs the contact patch length claim 2 , the inflation pressure level claim ...

SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold. 10. A compound as in claim 8 , wherein the pharmaceutically acceptable salt thereof is selected from the group consisting of sodium salt claim 8 , potassium salt and methanesulfonic acid salt.11. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of .12. A process for making a pharmaceutical composition comprising mixing a compound of and a pharmaceutically acceptable carrier.13. A method for inhibiting Icilin and CCI comprising administering to a mammal an effective amount of a compound as in .1431-. (canceled)32. A compound as in claim 4 , wherein{'sup': 1', '2', '3, 'sub': '3', 'Ris selected from the group consisting of chloro and trifluoromethyl; Ris hydrogen; Ris —OCH; Q is selected from the group consisting of 1-methyl-3-tert-butyl-4-chloro-pyrazol-5-yl and 1-methyl-3-tert-butyl-4-cyano-pyrazol-5-yl;'}or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof.3335-. (canceled) The present application claims the benefits of the filing of U.S. Provisional Application No. 61/310,870 filed Mar. 5, 2010. The complete disclosures of the aforementioned related patent applications are hereby incorporated herein by reference for all purposes.The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the TRPM8 (transient receptor potential, melastatin subfamily, ...

Tyrosine Kinome

Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in ˜20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention. 196.-. (canceled)97. A method of testing a sample of a human , comprising:determining sequence of NTRK3 in a sample of a cancer tissue; anddetecting a somatic mutation in NTRK3 in the cancer tissue.98. The method of wherein the mutation activates protein kinase activity.99. The method of wherein a DNA molecule of the cancer tissue is contacted with a reagent to determine a sequence feature of NTRK3.100. The method of wherein the step of determining comprises the step of amplifying at least one exon of NTRK3.101. The method of wherein the cancer tissue is a colorectal cancer tissue.102. The method of wherein nucleic acids are isolated from the cancer tissue prior to the step of determining.103. The method of further comprising administering an anti-cancer therapeutic agent to the human.104. The method of further comprising administering an anti-colorectal cancer therapeutic agent to the human.105. The method of wherein the mutation is selected from the group consisting of 1695V claim 97 , G608S claim 97 , L760I claim 97 , K732T claim 97 , and R731Q.106. The method of wherein the somatic mutation is in a residue that is evolutionarily conserved.107. The method of wherein the mutation is in a residue within a kinase domain.108. The method of wherein the mutation is a single base pair substitution. This invention was made using funds from the United States government under grants NIH Award CA ...

Adaptive flashlight control module

A portable lighting device control module configured to intuitively adjust lighting operations of a portable lighting device by interpreting real-time user gestures and external conditions of the portable lighting device to modifying lighting operations in response thereto. The control module installed within a portable lighting device may be configured to permit automatic dimming of front-end LEDs, enable a low power standby mode in absence of motion being detected, automatic mode adjustments in response to low battery determination, adjustment to lantern mode when a bump gesture is detected, continuous alternation between modes within lantern mode by detecting subsequent bump gestures, exiting lantern mode by detecting orientation, locking the lighting operation to a specific mode by determining orienting as either upwards or downwards, switching between modes by performing twist and return gestures, switching between modes by performing whip gestures, instantaneously dimming the light intensity by twisting the portable lighting device.

TIRE LIFT-OFF PROPENSITY PREDICTIVE SYSTEM AND METHOD

A system for predicting tire lift-off propensity of a vehicle tire includes a vehicle tire-affixed tire-identification device for providing a tire-specific identification, multiple tire-affixed sensors mounted to the tire measuring tire-specific parameters and generating tire-specific parameter information, one or more vehicle-affixed sensor(s) mounted to the vehicle to measure vehicle speed and a lift-off propensity estimator generating a lift-off propensity for the vehicle tire from a database containing experimentally-derived, tire-ID specific, lift-off propensities correlated with measured tire-specific parameter information and vehicle speeds. 1. A lift-off propensity predictive system comprising:a vehicle supported by at least one vehicle tire mounted to a hub, the vehicle tire having a tire cavity and a ground-engaging tread, and the tire having a plurality of tire-specific measureable parameters;a tire-affixed tire-identification device for providing a tire-specific identification;a plurality of tire-affixed sensors mounted to the tire operably measuring the tire-specific parameters and generating tire-specific parameter information;at least one vehicle-affixed sensor mounted to the vehicle operably measuring vehicle speed;a lift-off propensity estimator operable to generate a lift-off propensity for the one vehicle tire from a database containing experimentally-derived, tire-ID specific, lift-off propensities correlated to measured tire-specific parameter information and measured vehicle speeds.2. The lift-off propensity predictive system for a tire according to claim 1 , wherein the tire-specific parameter information is from the group:a load estimation for the one vehicle tire;air pressure within a cavity of the one vehicle tire; anda wear estimation for a tread region of the one vehicle tire.3. The lift-off propensity predictive system according to claim 2 , wherein the load estimation operably calculates a load estimation based upon a vehicle-based hub ...

Consensus Coding Sequences of Human Breast and Colorectal Cancers

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring. 1. A method of testing a human sample , comprising the step of:testing a test colorectal sample or a suspected colorectal cancer metastasis of the human, and detecting in a gene or its encoded cDNA or protein IDH1 R132C.2. The method of wherein IDH1 R132C is detected in the gene.3. The method of wherein IDH1 R132C is detected in the encoded cDNA.4. The method of wherein IDH1 R132C is detected in the protein.5. The method of wherein all or part of IDH1 gene is sequenced.6. The method of wherein the step of testing involves a probe specific for IDH1 R132C.7. The method of wherein the step of testing involves a primer specific for IDH1 R132C.8. The method of wherein the step of testing involves an antibody specific for IDH1 R132C.9. The method of wherein the step of testing involves a hybridization reaction.10. The method of wherein the step of testing involves a primer extension reaction.11. A method to stratify colorectal cancers for testing candidate or known anti-cancer therapeutics claim 1 , comprising the steps of:testing and detecting a R132C IDH1 codon or amino acid residue in a test sample of the human;forming a first group of colorectal cancers that have the codon or amino acid residue;testing sensitivity of the first group to a candidate or known anti-cancer therapeutic and ...

METHOD FOR CONTINUED BOUNDING VOLUME HIERARCHY TRAVERSAL ON INTERSECTION WITHOUT SHADER INTERVENTION

A hardware-based traversal coprocessor provides acceleration of tree traversal operations searching for intersections between primitives represented in a tree data structure and a ray. The primitives may include opaque and alpha triangles used in generating a virtual scene. The hardware-based traversal coprocessor is configured to determine primitives intersected by the ray, and return intersection information to a streaming multiprocessor for further processing. The hardware-based traversal coprocessor is configured to omit reporting of one or more primitives the ray is determined to intersect. The omitted primitives include primitives which are provably capable of being omitted without a functional impact on visualizing the virtual scene. 1. (canceled)2. A system comprising:memory configured to store at least a portion of a data structure including a plurality of hierarchical nodes, wherein at least one of said hierarchical nodes identifies a plurality of primitives of a virtual scene; and receive ray information;', 'determine, in response to the received ray information, which of the plurality of primitives are intersected by a ray; and', 'report two or more of the plurality of primitives determined to be intersected by the ray while omitting to report at least one of the plurality of primitives determined to be intersected by the ray., 'circuitry operatively coupled to the memory configured to3. The system of claim 2 , wherein the plurality of primitives determined to be intersected by the ray includes one or more alpha primitives and one or more opaque primitives claim 2 , and the at least one primitive that is omitted from being reported includes an opaque primitive.4. The system of claim 2 , wherein the plurality of primitives determined to be intersected by the ray includes one or more alpha primitives and one or more opaque primitives claim 2 , and the at least one primitive that is omitted from being reported includes at least one opaque primitive and at ...

HIGH PRESSURE AIR CYLINDERS FOR USE WITH SELF-CONTAINED BREATHING APPARATUS

A self-contained breathing apparatus includes an air cylinder pressurized to about 5500 psi, wherein the air cylinder is compatible with infrastructure used in conjunction with the air cylinder. The self-contained breathing apparatus also includes a first regulator valve for reducing air pressure from the air cylinder to a predetermined level. A second regulator valve is also provided for reducing the air pressure from the predetermined level to a level suitable for use by an operator, wherein air is supplied from the second regulator valve to the operator via a mask. The self-contained breathing apparatus further includes a frame for supporting the air cylinder on the back of the operator. Other embodiments are described and claimed. 221-. (canceled) This is a continuation application of U.S. patent application Ser. No. 13/217,703 filed Aug. 25, 2011 which claims the benefit of priority to U.S. Provisional Patent Application No. 61/519,603, filed May 25, 2011, the entirety of each is incorporated by reference herein.The present disclosure relates generally to self-contained breathing apparatus, and more particularly to self-contained breathing apparatus having an improved air cylinder configuration that is lighter and smaller than conventional air cylinders while providing desired air capacity and compatibility with existing infrastructure.A self-contained breathing apparatus (SCBA) used by a firefighter generally includes a pressurized air cylinder for supplying breathable air, a pressure regulator, an inhalation connection (mouthpiece, mouth mask or face mask) and other devices mounted to a frame that is carried by the firefighter. The configuration of the air cylinder is typically a result of the consideration of several design factors. These include items such as size, weight, amount of air supply required, portability, compatibility with other standardized equipment and the like. Current air cylinders for firefighters are pressurized to approximately 2216 ...

TIRE LOAD ESTIMATION SYSTEM AND METHOD

A tire load estimation system includes at least one tire supporting a vehicle, in which the at least one tire includes a pair of sidewalls extending to a circumferential tread. A sensor is mounted to the at least one tire. A footprint is formed by the tread and includes a centerline with a footprint centerline length. The footprint centerline length is measured by the sensor. A tire load estimator receives a precalibrated sensitivity, the footprint centerline length during straight-line driving conditions, a reference footprint value, and a reference load value as inputs. The tire load estimator determines an estimation of tire load and outputs the estimation to at least one of a vehicle control system and a vehicle electronic control unit. A method for estimating the load of a tire is also provided. 1. A tire load estimation system comprising:at least one tire supporting a vehicle, the at least one tire including a pair of sidewalls extending to a circumferential tread;a sensor mounted to the at least one tire;a footprint formed by the tread, the footprint including a centerline with a footprint centerline length, wherein the footprint centerline length is measured by the sensor;a tire load estimator, the tire load estimator receiving as inputs:a pre-calibrated sensitivity;the footprint centerline length during straight-line driving conditions;a reference footprint value; anda reference load value, wherein the tire load estimator determines an estimation of tire load and outputs the estimation to at least one of a vehicle control system and a vehicle electronic control unit.2. The tire load estimation system of claim 1 , further comprising an event detection module to select measurements of the footprint centerline length during straight-line driving conditions for input into the tire load estimator.3. The tire load estimation system of claim 2 , wherein:the event detection module receives as an input at least one of a steering wheel angle, a yaw rate, a gas pedal ...

FOLDABLE GOAL FRAME

A goal frame for a goal apparatus the goal frame including a crossbar member, a first and a second goalpost member, a support member, and a rotatable attachment member. Respective ends of the crossbar member are attached to, or are operable to attach to, a respective end of the first and second goal post members to form a goal face. The attachment of the respective end of the crossbar member to the end of the first goal post member forms a crossbar-goalpost corner portion of the goal face. The rotatable attachment member is attached to, or is operable to attach to, the goal face adjacent to the crossbar-goalpost corner portion. The rotatable attachment member is attached to, or is operable to attach to, an end of the support member. The rotatable attachment member is operable to rotate about the part of the goal face to which it is attached from a first position in which the attached support member extends outwardly from the goal face to a second position in which the attached support member extends along substantially the same plane as the goal face. 1. A goal frame for a goal apparatus , the goal frame comprising a crossbar member , a first and a second goalpost member , a support member , and a rotatable attachment member , wherein respective ends of the crossbar member are attached to , or are operable to attach to , a respective end of the first and second goalpost members to form a goal face , wherein the attachment of the respective end of the crossbar member to the end of the first goalpost member forms a crossbar-goalpost corner portion of the goal face , wherein the rotatable attachment member is attached to , or is operable to attach to , the goal face adjacent to the crossbar-goalpost corner portion , wherein the rotatable attachment member is attached to , or is operable to attach to , an end of the support member , and wherein the rotatable attachment member is operable to rotate about the part of the goal face to which it is attached from a first ...

DYNAMIC TIRE SLIP ANGLE ESTIMATION SYSTEM AND METHOD

A dynamic slip angle estimation system and method uses measured vehicle acceleration and yaw rate parameters in estimating a tire slip angle. From load sensor(s) mounted to the vehicle tire, a tire static load estimation is made and a tire slip angle is calculated at low frequency. The vehicle center of gravity longitudinal position and yaw moment of inertia is estimated from the static load on the vehicle tires. An observer calculates tire axle forces based on the vehicle acceleration and yaw rate. From the tire axle force estimations, the vehicle moment of inertia and vehicle center of gravity longitudinal position estimate and a low frequency direct measurement of the tire slip angle, a dynamic tire slip angle calculation is made. 1. A slip angle estimation system for estimating a tire slip angle comprising:at least one tire supporting a vehicle;vehicle sensor means mounted to the vehicle for providing measured vehicle acceleration and yaw rate parameters;static load sensor means mounted to the vehicle tire for providing a tire static load measurement;tire slip angle estimation means for estimating a tire slip angle from the tire static load measurement, and the vehicle acceleration and yaw rate parameters.2. The slip angle estimation system of claim 1 , wherein further comprising:center of gravity calculating means for calculating a vehicle center of gravity longitudinal position; andvehicle moment of inertia calculating means for calculating a vehicle moment of inertia from the tire static load measurement.3. The slip angle estimation system of claim 2 , wherein the tire slip angle estimation means comprises an observer having as observed inputs the vehicle acceleration and the yaw rate parameters and the observer further having as an output tire axle forces based on the observed inputs.4. The slip angle estimation system of claim 3 , wherein the observer comprises an online nonlinear axle-force estimator.5. The slip angle estimation system of claim 4 , wherein ...

VEHICLE DYNAMIC LOAD ESTIMATION SYSTEM AND METHOD

A dynamic load estimation system and method is provided, the system including a tire supporting a vehicle; a vehicle-mounted acceleration sensor for determining a vehicle lateral acceleration and a vehicle longitudinal acceleration; a roll angle calculating model for determining a vehicle roll angle; a roll rate calculating model for determining a vehicle roll rate; a static normal load calculation model for calculating a measured static normal load; and a dynamic tire load estimation model for calculating an estimated dynamic load on the tire from the measured static normal load, the vehicle roll angle, the vehicle roll rate, the vehicle lateral acceleration and the vehicle longitudinal acceleration. 1. A dynamic load estimation system for estimating a vehicle load comprising:at least one tire supporting a vehicle;acceleration sensor means for determining a vehicle lateral acceleration and a vehicle longitudinal acceleration;roll angle calculating means for determining a vehicle roll angle;roll rate calculating means for determining a vehicle roll rate;static normal load calculation means for calculating a measured static normal load; anddynamic tire load estimation means for calculating an estimated dynamic load on the tire from the measured static normal load, the vehicle roll angle, the vehicle roll rate, the vehicle lateral acceleration and the vehicle longitudinal acceleration.2. The dynamic load estimation system of claim 1 , wherein further comprising:tire sensor means for determining a measured load transfer force on the one tire;adaptive load transfer ratio estimation means for determining an adaptive load transfer ratio estimation based on the vehicle lateral acceleration and the vehicle longitudinal acceleration;load transfer ratio generating means for determining a load transfer ratio from the measured load transfer force and the adaptive load transfer ratio estimation;roll angle estimation means for generating a roll angle estimation based on the load ...

ADAPTIVE FLASHLIGHT CONTROL MODULE

A portable lighting device control module configured to intuitively adjust lighting operations of a portable lighting device by interpreting real-time user gestures and external conditions of the portable lighting device to modifying lighting operations in response thereto. The control module installed within a portable lighting device may be configured to permit automatic dimming of front-end LEDs, enable a low power standby mode in absence of motion being detected, automatic mode adjustments in response to low battery determination, adjustment to lantern mode when a bump gesture is detected, continuous alternation between modes within lantern mode by detecting subsequent bump gestures, exiting lantern mode by detecting orientation, locking the lighting operation to a specific mode by determining orienting as either upwards or downwards, switching between modes by performing twist and return gestures, switching between modes by performing whip gestures, instantaneously dimming the light intensity by twisting the portable lighting device. 1. A lighting control module for use with a multipurpose lighting device , the lighting control module comprising:a microcontroller having a plurality of lighting device output modes stored in memory;an ambient light sensor configured to measure light intensity external to the multipurpose lighting device and transmit ambient light sensor data, including real-time light intensity measurements, to the microcontroller;the microcontroller having program logic configured to select and adjust the lighting device output modes and initiate and adjust an intensity of one or more light sources of the multipurpose lighting device using pulse width modulation brightness controls responsive to the ambient light sensor data.2. The lighting control module of claim 1 , further comprising:a first directional connection and a second directional connection configured to communicate with a first light source; anda first area light connection and ...

SHELVING SYSTEM

An article support, such as a shelf, is securely attachable at a plurality of locations along a generally vertical support or rail. The article support includes a support-engaging portion having one or more tabs, at least one of which is a locking tab having a forward-extending tooth that engages the vertical support, when the tab or tabs extend through slots in the support. Optionally, a biasing element urges the article away from the support to maintain secure engagement of the locking tab with the support. The resulting shelving system or article support system is resistant to accidental detachment of the article supports from the supports and permits relatively small adjustment intervals for the article supports along the supports. 1. A shelving system for storage or display of articles , said shelving system comprising:a generally vertical support comprising at least one rail defining a plurality of generally vertically-spaced slots;a shelf including an article-supporting surface and a support-engaging portion for releasably attaching said shelf to said rail at said slots;said support-engaging portion of said shelf including at least one locking tab configured for insertion into said slots of said rail, said at least one locking tab comprising a rearward projection having a distal end portion, a downward projection portion extending downwardly from said distal end portion, and a tooth extending forwardly from said downward projection portion; andbiasing element for applying a force that urges said shelf in a direction away from said rail, to thereby maintain engagement of said tooth with said rail, said biasing element comprises a leaf spring extending rearwardly from said shelf portion to engage and apply a force against said rail;wherein said locking tab is configured to be received in a first slot and said tooth of said locking tab is configured to engage said rail at or near a second slot for securing said shelf against unintentional disengagement from said ...

ADAPTIVE FLASHLIGHT CONTROL MODULE

A portable lighting device control module configured to intuitively adjust lighting operations of a portable lighting device by interpreting real-time user gestures and external conditions of the portable lighting device to modifying lighting operations in response thereto. The control module installed within a portable lighting device may be configured to permit automatic dimming of front-end LEDs, enable a low power standby mode in absence of motion being detected, automatic mode adjustments in response to low battery determination, adjustment to lantern mode when a bump gesture is detected, continuous alternation between modes within lantern mode by detecting subsequent bump gestures, exiting lantern mode by detecting orientation, locking the lighting operation to a specific mode by determining orienting as either upwards or downwards, switching between modes by performing twist and return gestures, switching between modes by performing whip gestures, instantaneously dimming the light intensity by twisting the portable lighting device. 1. A lighting control module for use with a multipurpose lighting device , the lighting control module comprising:a microcontroller having a plurality of lighting device output modes stored in memory;one or more sensors, each being configured to detect motion of or external to the multipurpose lighting device and transmit data to the microcontroller,wherein the control module is configured to receive power from a battery,wherein the microcontroller is configured to select and adjust the lighting device output modes and initiate and adjust an intensity of one or more light sources of the multipurpose lighting device using pulse width modulation brightness controls responsive to the data received from the one or more sensors.2. The lighting control module of claim 1 , wherein the one or more sensors comprise an inertial sensor.3. The lighting control module of claim 2 , wherein the inertial sensor comprises an accelerometer.4. The ...

TIRE SENSOR

An assembly determines operating parameters of a tire. The assembly includes a tripod sensor mounted within an inner cavity of the tire underneath a crown portion and an innerliner on which the tripod sensor is mounted. The tripod sensor includes a tri-axial accelerometer for creating a circumferential signal for determining slip ratio, a lateral signal for determining a slip angle, and a radial signal for determining load on the tire. 1. An assembly for determining operating parameters of a tire comprising:a tripod sensor mounted within an inner cavity of the tire underneath a crown portion and an innerliner on which the tripod sensor is mounted, the tripod sensor including a tri-axial accelerometer for creating a circumferential signal for determining slip ratio, a lateral signal for determining a slip angle, and a radial signal for determining load on the tire.2. A tire wear state estimation system comprising:at least one tire supporting a vehicle;a tri-axial sensor mounted to the tire, the tri-axial sensor measuring tire inflation pressure and generating tire inflation pressure data, measuring tire vertical mode frequency and generating tire vertical mode frequency data, generating tire-specific frequency mode coefficients using tire-specific identification data, and calculating an estimation of a tire wear state based upon the tire inflation pressure data, the vertical mode frequency data, and the tire-specific frequency mode coefficients.3. The tire wear state estimation system of wherein the tri-axial sensor comprises a tire-mounted pressure measuring device operative to measure a tire cavity pressure and transmit the tire inflation pressure data derived from the tire cavity pressure measurement.4. The tire wear state estimation system of wherein the tri-axial sensor comprises tire-specific identification data stored therein.5. The tire wear state estimation system of wherein tire-specific frequency mode coefficients are generated by the tri-axial sensor ...

METHOD AND SYSTEM FOR DISPENSING A COMPOSITION

A dispensing system includes a substrate made of a porous material that defines a channel. The system also includes a base in contact with the substrate, A container for discharging a flowable medium into the channel is completely accommodated within the base and is partially exterior to the substrate. 1. A dispensing system , comprising:a substrate made of a porous material and defining a channel; anda base in contact with the substrate,wherein a container for discharging a flowable medium into the channel is completely accommodated within the base and is partially exterior to the substrate.2. The dispensing system of claim 1 , wherein a discharge of the flowable medium creates a visible plume within the channel.3. The dispensing system of claim 2 , wherein the plume is visible beyond a boundary of the substrate.4. The dispensing system of claim 3 , wherein the plume is visible beyond the boundary of the substrate for at least 1 second.5. The dispensing system of claim 4 , wherein the plume is visible beyond the boundary of the substrate for between 1 second to 2 seconds.6. The dispensing system of claim 2 , wherein the plume has a particle size distribution that is less than or equal to 30 μm for a Dv(90) particle size distribution at an upper end of the substrate.7. The dispensing system of claim 1 , wherein the substrate comprises:a median pore diameter by volume of between 50 μm and 80 μm; anda porosity of between 1.55 mL/g to 7.13 mL/g.8. A dispensing system claim 1 , comprising:a porous substrate having a channel; anda mechanism for discharging a flowable medium into the channel,wherein the mechanism includes an upper housing and a lower housing, and the upper housing is movable with respect to the lower housing, andwherein a discharge of the flowable medium creates a visible plume within the channel.9. The dispensing system of claim 8 , wherein the plume is visible beyond a boundary of the substrate.10. The dispensing system of claim 9 , wherein the plume is ...

Consensus Coding Sequences of Human Breast and Colorectal Cancers

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring. 1. (canceled)2. A method of testing a human sample , comprising the step of:testing a test colorectal sample of the human by subjecting the sample to a reaction, and detecting an asparagine codon or residue in a gene or its encoded cDNA or protein at KRAS codon or residue 117.3. The method of wherein an asparagine codon is detected at KRAS codon 117 in the gene.4. The method of wherein an asparagine is detected at KRAS codon 117 in the encoded cDNA.5. The method of wherein an asparagine residue is detected at KRAS residue 117 in the protein.6. The method of wherein a sequencing reaction is run on all or a part of KRAS gene including codon 117.7. The method of wherein the step of testing comprises a step of contacting (a) a probe specific for KRAS with an asparagine codon at codon 117 with (b) the test colorectal sample.8. The method of wherein the step of testing comprises a step of contacting (a) a primer specific for KRAS with an asparagine codon at codon 117 with (b) the test colorectal sample.9. The method of wherein the step of testing comprises a step of contacting (a) an antibody specific for KRAS with an asparagine residue at residue 117 with (b) the test colorectal sample.10. The method of wherein the step of testing comprises a hybridization reaction between the test ...

GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. 1. (canceled)2. A method of treating a mutant isocitrate dehydrogenase 2 (IDH2) enzyme-associated cancer in a subject comprising:detecting the presence of an isocitrate dehydrogenase 2 (IDH2) mutation in a nucleic acid present in a sample obtained from the subject; andadministering to the subject an anti-cancer agent selected from the group consisting of a chemotherapeutic agent and a biological agent to treat the tumor, wherein the anti-cancer agent inhibits the activity of the mutant IDH2 enzyme.3. The method of claim 2 , wherein the IDH2 mutation is present in a mutant codon that corresponds to a wild type codon that encodes amino acid 172 in the wild type IDH2 polypeptide of SEQ ID NO: 131.4. The method of claim 3 , wherein the mutant codon that includes the IDH2 mutation encodes an amino acid selected from the group consisting of: methionine (M) claim 3 , lysine (K) claim 3 , and glycine (G).5. The method of claim 2 , wherein the presence of an IDH2 mutation in the sample is detected using an amplification primer claim 2 , a hybridization probe claim 2 , or both.6. The method of claim 5 , wherein:the amplification primer comprises at least 10 but fewer than 600 contiguous nucleotide residues of a coding sequence of a IDH2 protein found in a tumor of the subject, or its complement, the at least 10 contiguous nucleic acid residues comprising:a first nucleotide that is present at a position in a mutant codon that corresponds to a wild type codon that encodes amino acid 172 in the wild type IDH2 polypeptide of SEQ ID NO: 131, ...

TIRE WEAR STATE ESTIMATION SYSTEM AND METHOD

The invention relates generally to tire monitoring systems for collecting measured tire parameter data during vehicle operation and, more particularly, to a system and method for estimating tire wear state based upon such measurements. 1. A tire wear state estimation system comprising: tire pressure measuring means affixed to the one tire for measuring tire inflation pressure and generating tire inflation pressure data;', 'tire vertical mode measuring means for measuring tire vertical mode frequency and generating tire vertical mode frequency data;', 'tire identification means for generating tire-specific frequency mode coefficients using tire-specific identification data; and, 'at least one tire supporting a vehicle;'}tire wear estimation means for calculating an estimation of a tire wear state based upon the tire inflation pressure data, the vertical mode frequency data, and the tire-specific frequency mode coefficients.2. The tire wear state estimation system of claim 1 , wherein the tire pressure measuring means comprises a tire-mounted pressure measuring device operative to measure a tire cavity pressure and transmit the tire inflation pressure data from the tire cavity pressure measurement.3. The tire wear state estimation system of claim 2 , wherein the tire identification means comprises tire-specific identification data stored within and accessible from the tire-mounted pressure measuring device.4. The tire wear state estimation system of claim 3 , wherein the tire-specific frequency mode coefficients are generated by the tire identification means using on-vehicle or in-tire measurement of a tire vertical mode frequency.5. The tire wear state estimation system of claim 4 , wherein the measurement of the tire vertical mode frequency is from a wheel-mounted accelerometer or a tire crown-mounted accelerometer.6. The tire wear state estimation system of claim 4 , wherein the tire wear estimation means comprises a correlation model between the tire wear state ...

Genomic Landscapes of Human Breast and Colorectal Cancers

Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy. 1. A method to stratify breast cancers for testing candidate or known anti-cancer therapeutics , comprising the steps of:determining a CAN-gene mutational signature for a breast cancer by determining at least one somatic mutation in a test sample relative to a normal sample of a human, wherein the at least one somatic mutation is in MED12;forming a first group of breast cancers that have the CAN-gene mutational signature;comparing efficacy of a candidate or known anti-cancer therapeutic on the first group to efficacy on a second group of breast cancers that has a different CAN-gene mutational signature;identifying a CAN gene mutational signature which correlates with increased or decreased efficacy of the candidate or known anti-cancer therapeutic relative to other groups.2. The method of wherein the CAN-gene mutational signature comprises at least one mutation selected from those shown in (Table S3).3. The method of wherein the test sample is a breast tissue sample.4. The method of wherein the normal sample is a breast tissue sample.5. The method of wherein the CAN-gene mutational signature comprises ...

GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. 1. (canceled)2. A method of treating a mutant isocitrate dehydrogenase 2 (IDH2) enzyme-associated cancer in a subject comprising:detecting the presence of an isocitrate dehydrogenase 2 (IDH2) mutation in a nucleic acid present in a sample obtained from the subject; andadministering to the subject an anti-cancer agent selected from the group consisting of a chemotherapeutic agent and a biological agent to treat the tumor, wherein the anti-cancer agent inhibits the activity of the mutant IDH2 enzyme.3. The method of claim 2 , wherein the IDH2 mutation is present in a mutant codon that corresponds to a wild type codon that encodes amino acid 172 in the wild type IDH2 polypeptide of SEQ ID NO: 131.4. The method of claim 3 , wherein the mutant codon that includes the IDH2 mutation encodes an amino acid selected from the group consisting of: methionine (M) claim 3 , lysine (K) claim 3 , and glycine (G).5. The method of claim 2 , wherein the presence of an IDH2 mutation in the sample is detected using an amplification primer claim 2 , a hybridization probe claim 2 , or both.6. The method of claim 5 , wherein:the amplification primer comprises at least 10 but fewer than 600 contiguous nucleotide residues of a coding sequence of a IDH2 protein found in a tumor of the subject, or its complement, the at least 10 contiguous nucleic acid residues comprising:a first nucleotide that is present at a position in a mutant codon that corresponds to a wild type codon that encodes amino acid 172 in the wild type IDH2 polypeptide of SEQ ID NO: 131, ...

ROBUST, EFFICIENT MULTIPROCESSOR-COPROCESSOR INTERFACE

Systems and methods for an efficient and robust multiprocessor-coprocessor interface that may be used between a streaming multiprocessor and an acceleration coprocessor in a GPU are provided. According to an example implementation, in order to perform an acceleration of a particular operation using the coprocessor, the multiprocessor: issues a series of write instructions to write input data for the operation into coprocessor-accessible storage locations, issues an operation instruction to cause the coprocessor to execute the particular operation; and then issues a series of read instructions to read result data of the operation from coprocessor-accessible storage locations to multiprocessor-accessible storage locations. 1establishing a connection to the coprocessor;issuing a plurality of write instructions to write input data for the operation into coprocessor-accessible storage locations;issuing an operation instruction to cause the coprocessor to execute the operation using said input data;issuing a plurality of read instructions to read result data of the operation from coprocessor-accessible storage locations to multiprocessor-accessible storage locations; andclosing the connection.. A method performed by a multiprocessor to execute an operation on a communicatively coupled coprocessor, the method comprising: This application is a continuation of U.S. application Ser. No. 16/101,247 filed Aug. 10, 2018, related to the following commonly-assigned US patents and patent applications, the entire contents of each of which are incorporated by reference: U.S. application Ser. No. 14/563,872 titled “Short Stack Traversal of Tree Data Structures” filed Dec. 8, 2014; U.S. Pat. No. 9,582,607 titled “Block-Based Bounding Volume Hierarchy”; U.S. Pat. No. 9,552,664 titled “Relative Encoding For A Block-Based Bounding Volume Hierarchy” as; U.S. Pat. No. 9,569,559 titled “Beam Tracing” filed Mar. 18, 2015; U.S. Pat. No. 10,025,879 titled “Tree Data Structures Based on a ...

EARLY RELEASE OF RESOURCES IN RAY TRACING HARDWARE

Techniques are disclosed for improving the throughput of ray intersection or visibility queries performed by a ray tracing hardware accelerator. Throughput is improved, for example, by releasing allocated resources before ray visibility query results are reported by the hardware accelerator. The allocated resources are released when the ray visibility query results can be stored in a compressed format outside of the allocated resources. When reporting the ray visibility query results, the results are reconstructed based on the results stored in the compressed format. The compressed format storage can be used for ray visibility queries that return no intersections or terminate on any hit ray visibility query. One or more individual components of allocated resources can also be independently deallocated based on the type of data to be returned and/or results of the ray visibility query. 1. A ray tracing hardware method comprising:(a) performing an intersection test to provide an intersection test result; and(b) selecting, based on the intersection test result, whether to report the intersection test to a cooperating processor using data collected from the intersection test or using data that was predetermined before the intersection test was performed.2. The ray tracing method of further including selectively deallocating on-chip memory used to collect data from the intersection test upon determining claim 1 , based on the intersection test result claim 1 , that the intersection test result will be reported using the data that was predetermined before the intersection test was performed.3. The ray tracing method of wherein the selecting selects claim 1 , whenever the intersection test result is a miss claim 1 , using data that was predetermined before the intersection test was performed.4. The ray tracing method of further including using the same report format representation for each of using data collected from the intersection test and using data that was ...

SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold. 10. A compound as in claim 8 , wherein the pharmaceutically acceptable salt thereof is selected from the group consisting of sodium salt claim 8 , potassium salt and methanesulfonic acid salt.11. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of .12. A process for making a pharmaceutical composition comprising mixing a compound of and a pharmaceutically acceptable carrier.13. A method for treating inflammatory pain or neuropathic pain comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound as in .14. A method as in claim 13 , wherein the inflammatory pain is due to inflammatory bowel disease claim 13 , visceral pain claim 13 , migraine claim 13 , post operative pain claim 13 , osteoarthritis claim 13 , rheumatoid arthritis claim 13 , back pain claim 13 , lower back pain claim 13 , joint pain claim 13 , abdominal pain claim 13 , chest pain claim 13 , labor claim 13 , musculoskeletal diseases claim 13 , skin diseases claim 13 , toothache claim 13 , pyresis claim 13 , burn claim 13 , sunburn claim 13 , snake bite claim 13 , venomous snake bite claim 13 , spider bite claim 13 , insect sting claim 13 , neurogenic bladder claim 13 , interstitial cystitis claim 13 , urinary tract infection claim 13 , rhinitis claim 13 , contact dermatitis/hypersensitivity claim 13 , itch claim 13 , eczema claim 13 , pharyngitis claim 13 , mucositis claim 13 , enteritis claim 13 , ...

LACTONE COMPOUNDS AND METHODS OF MAKING AND USING SAME

Provided herein are lactone compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as inhibitors of serine hydrolases, such as ABHD16A. Furthermore, the subject compounds and compositions may be useful for the treatment of, for example, PHARC and other neuroinflammatory diseases. 2. The compound of claim 1 , wherein Ris alkyl or -alkylene-(optionally substituted phenyl).3. The compound of or claim 1 , wherein Ris optionally substituted phenyl claim 1 , —(CH)—CH claim 1 , —(CH)-(optionally substituted phenyl) claim 1 , —(CH)—C(O)NRR claim 1 , or —(CH)—SONRR.4. The compound of any one of - claim 1 , wherein Rand Rare both H.5. The compound of any one of - claim 1 , wherein Rand Rare both H.6. The compound of any one of - claim 1 , wherein Rand Rtogether form a direct bond to provide a double bond.7. The compound of any one of - claim 1 , wherein X is O.8. The compound of any one of - claim 1 , wherein X is CH.10. The compound of claim 9 , wherein Ris alkyl or -alkylene-(optionally substituted phenyl).11. The compound of or claim 9 , wherein Ris optionally substituted phenyl claim 9 , —(CH)—CH claim 9 , —(CH)-(optionally substituted phenyl) claim 9 , —(CH)—C(O)NRR claim 9 , or —(CH)—SONRR.12. The compound of any one of - claim 9 , wherein Rand Rare both H.13. The compound of any one of - claim 9 , wherein X is O.14. The compound of any one of - claim 9 , wherein X is CH.16. The compound of claim 15 , wherein Rand Rare both H.17. The compound of claim 15 , wherein Rand Rtogether form a direct bond to provide a double bond.18. The compound of any one of - claim 15 , wherein X is O.19. The compound of any one of - claim 15 , wherein X is CH.21. The compound of claim 20 , wherein X is O.22. The compound of claim 20 , wherein X is CH.24. The compound of claim 23 , wherein X is O.25. The compound of claim 23 , wherein X is CH.26. The compound of any one of - claim 23 , wherein Rand Rare both H.27. The compound ...

Tire lift-off propensity predictive system and method

A system for predicting tire lift-off propensity of a vehicle tire includes a vehicle tire-affixed tire-identification device for providing a tire-specific identification, multiple tire-affixed sensors mounted to the tire measuring tire-specific parameters and generating tire-specific parameter information, one or more vehicle-affixed sensor(s) mounted to the vehicle to measure vehicle speed and a lift-off propensity estimator generating a lift-off propensity for the vehicle tire from a database containing experimentally-derived, tire-ID specific, lift-off propensities correlated with measured tire-specific parameter information and vehicle speeds.

HIGH PRESSURE AIR CYLINDERS FOR USE WITH SELF-CONTAINED BREATHING APPARATUS

A self-contained breathing apparatus includes an air cylinder pressurized to about 5500 psig, wherein the air cylinder is compatible with infrastructure used in conjunction with the air cylinder. The self-contained breathing apparatus also includes a first regulator valve for reducing air pressure from the air cylinder to a predetermined level. A second regulator valve is also provided for reducing the air pressure from the predetermined level to a level suitable for use by an operator, wherein air is supplied from the second regulator valve to the operator via a mask. The self-contained breathing apparatus further includes a frame for supporting the air cylinder on the back of the operator. Other embodiments are described and claimed. 118-. (canceled)19. An assembly for a fire fighter self-contained breathing apparatus , comprising:a frame having a user support portion mounted to the frame; anda compressed gas cylinder mounted to the frame, the single cylinder including a pressure volume portion for containing a volume of gas pressurized to a service pressure of between about 5,000 and 6,000 psig, the pressure volume portion having a length, a diameter, and a water volume;wherein the cylinder further includes a gas transmission port coupled to a pressure regulator assembly; 'wherein at least one of a length and a diameter of the pressure volume portion is at least slightly less than at least one of a corresponding length and diameter of a compressed gas cylinder for a self-contained breathing apparatus having a service pressure of about 4500 psig.', 'wherein the pressure volume portion defines an operational parameter of the cylinder, the operational parameter being a relationship between free air capacity of the cylinder in liters and a rated service time in minutes; and'}20. The assembly of claim 19 , further comprising a first regulator valve connected to the compressed gas cylinder for fluid communication between the compressed gas cylinder and the first ...

High pressure air cylinders for use with self-contained breathing apparatus

A self-contained breathing apparatus includes an air cylinder pressurized to about 5500 psi, wherein the air cylinder is compatible with infrastructure used in conjunction with the air cylinder. The self-contained breathing apparatus also includes a first regulator valve for reducing air pressure from the air cylinder to a predetermined level. A second regulator valve is also provided for reducing the air pressure from the predetermined level to a level suitable for use by an operator, wherein air is supplied from the second regulator valve to the operator via a mask. The self-contained breathing apparatus further includes a frame for supporting the air cylinder on the back of the operator. Other embodiments are described and claimed.

Tire temperature predictive system and method

A tire-based system and method for estimating a radially outward tire surface temperature of an identified tire supporting an identified vehicle includes a temperature sensor to measure a tire inner liner temperature. An algorithmic prediction model is empirically trained to correlate inner liner tire temperature to tire radially outward surface temperature for the tire/vehicle combination. The empirically trained algorithmic prediction model receives a steady state temperature-based model inputs including the tire inner liner temperature and an ambient temperature measurement and transient behavior vehicle-based inputs. Based upon the steady state inputs and the transient behavior inputs, a radially outward tire surface temperature estimation is made.

HIGH PRESSURE AIR CYLINDERS FOR USE WITH SELF-CONTAINED BREATHING APPARATUS

A self-contained breathing apparatus includes an air cylinder pressurized to about 5500 psi, wherein the air cylinder is compatible with infrastructure used in conjunction with the air cylinder. The self-contained breathing apparatus also includes a first regulator valve for reducing air pressure from the air cylinder to a predetermined level. A second regulator valve is also provided for reducing the air pressure from the predetermined level to a level suitable for use by an operator, wherein air is supplied from the second regulator valve to the operator via a mask. The self-contained breathing apparatus further includes a frame for supporting the air cylinder on the back of the operator. Other embodiments are described and claimed. 2. The compressed gas cylinder of wherein the first pressure is about 5400 psi to about 5500 psi.3. The compressed gas cylinder of claim 1 , wherein the first pressure is about 5500 psi.4. The compressed gas cylinder of claim 1 , wherein the first pressure is about 5500 psi to about 5600 psi.5. The compressed gas cylinder of claim 1 , wherein the water volume is about 349 cubic inches.6. The compressed gas cylinder of claim 1 , wherein the pressure volume portion is configured to contain about 1200 liters of free air.7. The compressed gas cylinder of claim 6 , wherein the cylinder has a weight from about 5.7 pounds to about 6.6 pounds.8. The compressed gas cylinder of claim 7 , wherein the length of the pressure volume portion is about 14.8 inches to about 17.3 inches claim 7 , and the diameter of the pressure volume portion is about 4.3 inches to about 4.7 inches.9. The compressed gas cylinder of claim 1 , wherein the pressure volume portion is configured to contain about 1800 liters of free air.10. The compressed gas cylinder of claim 9 , wherein the weight is about 7.8 to about 9.0 pounds.11. The compressed gas cylinder of claim 10 , wherein the length of the pressure volume portion is about 16.9 inches to about 19.5 inches claim 10 ...

High pressure air cylinders for use with self-contained breathing apparatus

A self-contained breathing apparatus includes an air cylinder pressurized to about 5500 psi, wherein the air cylinder is compatible with infrastructure used in conjunction with the air cylinder. The self-contained breathing apparatus also includes a first regulator valve for reducing air pressure from the air cylinder to a predetermined level. A second regulator valve is also provided for reducing the air pressure from the predetermined level to a level suitable for use by an operator, wherein air is supplied from the second regulator valve to the operator via a mask. The self-contained breathing apparatus further includes a frame for supporting the air cylinder on the back of the operator. Other embodiments are described and claimed.

Consensus Coding Sequences of Human Breast and Colorectal Cancers

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring. 1. A method of treating a breast cancer in a human , comprising the steps of:{'figref': {'@idref': 'DRAWINGS', 'FIG. 13'}, 'b': '5', 'determining in a test sample relative to a normal sample of the human, a somatic mutation in a gene or its encoded cDNA or protein, said gene selected from the group consisting of those listed in (Table S);'}identifying the sample as breast cancer when the somatic mutation is determined; andadministering a medical intervention to the human when the human is identified as having the somatic mutation in the test sample.24. The method of wherein the mutation is selected from those shown in (Table S).3. The method of wherein the gene is selected from the group consisting of: gelsolin GSN claim 1 , cadherin genes CDH10 and CDH20 claim 1 , actin and SMAD binding protein filamin B FLNB claim 1 , and autocrine motility factor receptor AMFR.4. The method of wherein the gene is selected from the group consisting of: ATP-dependent transporter ATP8B1 claim 1 , intrinsic factor-cobalamin receptor CUBN claim 1 , actin binding protein DBN1 claim 1 , and tectorin alpha TECTA.5. The method of wherein the test sample is a breast tissue sample or a suspected breast cancer metastasis.6. The method of wherein the normal sample is a breast tissue sample.712-. (canceled)13. ...

METHOD FOR HANDLING OF OUT-OF-ORDER OPAQUE AND ALPHA RAY/PRIMITIVE INTERSECTIONS

A hardware-based traversal coprocessor provides acceleration of tree traversal operations searching for intersections between primitives represented in a tree data structure and a ray. The primitives may include opaque and alpha triangles used in generating a virtual scene. The hardware-based traversal coprocessor is configured to determine primitives intersected by the ray, and return intersection information to a streaming multiprocessor for further processing. The hardware-based traversal coprocessor is configured to provide a deterministic result of intersected triangles regardless of the order that the memory subsystem returns triangle range blocks for processing, while opportunistically eliminating alpha intersections that lie further along the length of the ray than closer opaque intersections. 1memory configured to store at least a portion of an acceleration data structure including a plurality of hierarchical nodes, at least one node identifying primitives of a virtual scene; and determine, in the order the primitives identified in the at least one node are received from memory, primitives which are intersected by a ray; and', 'report at least a portion of the primitives the ray is determined to intersect in a memory order the primitives are stored in the memory., 'autonomous hardware circuitry operatively coupled to the memory configured to. A system including: This application is related to the following commonly-assigned US patents and patent applications, the entire contents of each of which are incorporated by reference: U.S. application Ser. No. 14/563,872 titled “Short Stack Traversal of Tree Data Structures” filed Dec. 8, 2014; U.S. Pat. No. 9,582,607 titled “Block-Based Bounding Volume Hierarchy”; U.S. Pat. No. 9,552,664 titled “Relative Encoding For A Block-Based Bounding Volume Hierarchy” as; U.S. Pat. No. 9,569,559 titled “Beam Tracing” filed Mar. 18, 2015; U.S. Pat. No. 10,025,879 titled “Tree Data Structures Based on a Plurality of Local ...

HIGH PRESSURE-AIR CYLINDERS FOR USE WITH SELF-CONTAINED BREATHING APPARATUS

A self-contained breathing apparatus includes an air cylinder pressurized to about 5500 psi, wherein the air cylinder is compatible with infrastructure used in conjunction with the air cylinder. The self-contained breathing apparatus also includes a first regulator valve for reducing air pressure from the air cylinder to a predetermined level. A second regulator valve is also provided for reducing the air pressure from the predetermined level to a level suitable for use by an operator, wherein air is supplied from the second regulator valve to the operator via a mask. The self-contained breathing apparatus further includes a frame for supporting the air cylinder on the back of the operator. Other embodiments are described and claimed. 121-. (canceled)23. A self-contained breathing apparatus as defined in claim 22 , wherein the service pressure is at least about 5 claim 22 ,000 psig and no greater than about 5 claim 22 ,600 psig.24. A self-contained breathing apparatus as defined in claim 22 , wherein the service pressure is at least about 5 claim 22 ,600 psig and no greater than about 6 claim 22 ,000 psig.25. A self-contained breathing apparatus as defined in claim 22 , wherein the service pressure is at least about 5 claim 22 ,400 psig and no greater than about 5 claim 22 ,600 psig.26. A self-contained breathing apparatus as defined in claim 22 , wherein the cylinder has a space envelope claim 22 , weight and rotational inertia claim 22 , and wherein at least one of the space envelope claim 22 , weight and rotational inertia of the cylinder is less than the space envelope claim 22 , weight and rotational inertia of a cylinder having a similar rated service time but a lower service pressure.27. A self-contained breathing apparatus as defined in claim 22 , wherein the cylinder has a weight that is at least about 5% less than the weight of a cylinder having a similar rated service time but a service pressure of 4500 psig.28. A self-contained breathing apparatus as ...

O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives

O-Aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-42 and/or C-31. These compounds are useful in a mammalian host for the treatment of autoimmune diseases and diseases of inflammation, infectious diseases, the prevention of rejection of foreign organ transplants and the treatment of solid tumors.

Process for producing optical lenses from glass and apparatus for carrying out the process

Battery sleeve frame

A frame assembly for receiving and supporting batteries in at least one horizontal row comprises a pair of generally parallel spaced apart, aligned base supports with each base support having a front end and a rear end. Four vertical corner supports, including a front pair and a rear pair are secured to the base supports with the front pair of corner supports being generally equally spaced from the rear pair of corner supports. At least one pair of horizontal supports are secured to the corner supports. The horizontal support pair includes a front horizontal support and a rear horizontal support. Each horizontal support has two ends with each end of the front horizontal support being secured to one of the corner supports of the front pair of corner supports and with each end of the rear horizontal support being secured to one of the corner supports of the rear pair of corner supports. The horizontal supports are both secured at each end to the corner supports at a first predetermined distance from the base supports, the first predetermined distances being established so that at least one battery may be supported by the first pair of horizontal supports to establish a first horizontal battery row.

Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity

Aryl, alkyl, alkenyl and alkynyl macrolides of general structural formula (I); have been prepared from suitable precursors by oxidation and alkylation at C-4' of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

O-aryl, o-alkyl, o-alkenyl and o-alkynyl-macrolides having immunosuppressive activity

Substituted compounds of the FK-506 Type. These compounds are useful for the same or essentially the same purposes as FK-506 and are applied in the same or a similar manner. These compounds are immunosuppressants and useful for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. Still other uses are described in the disclosure.

Adaptive flashlight control module

A portable lighting device control module configured to intuitively adjust lighting operations of a portable lighting device by interpreting real-time user gestures and external conditions of the portable lighting device to modifying lighting operations in response thereto. The control module installed within a portable lighting device may be configured to permit automatic dimming of front-end LEDs, enable a low power standby mode in absence of motion being detected, automatic mode adjustments in response to low battery determination, adjustment to lantern mode when a bump gesture is detected, continuous alternation between modes within lantern mode by detecting subsequent bump gestures, exiting lantern mode by detecting orientation, locking the lighting operation to a specific mode by determining orienting as either upwards or downwards, switching between modes by performing twist and return gestures, switching between modes by performing whip gestures, instantaneously dimming the light intensity by twisting the portable lighting device.

Aryl-link-aryl substituted thiazolidine-dione and oxazolidine-dione as sodium channel blockers

Aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are sodium channel blockers; pharmaceutical compositions that include an effective amount of the aryl-link-aryl thiazolidine-dione and ary l- link-aryl oxazolidine-dione compounds and a pharmaceutically acceptable carrier; and a method of treatment of acute pain, chronic pain, visceral pai n, inflammatory pain, or neuropathic pain, as well as irritable bowel syndrome, Crohns disease, epilepsy, partial and generalized tonic seizures, multiple sclerosis, bipolar depression, and tachy-arrhythmias by the administration o f an effective amount of aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are described.

Benzamide potassium channel inhibitors

This invention relates to benzamide potassium channel inhibitors of general structural formula (I). The compounds of this invention are useful in the treatment of autoimmune diseases, the prevention of rejection of foreign org an transplants and related afflictions, diseases and illnesses, and cardiac arrhythmias. Also within the scope of this invention are pharmaceutical formulations comprising a compound of formula (I) and a pharmaceutical carrier, as well as pharmaceutical formulations comprising a compound of formula (I), one or more immunosuppressive compounds and a pharmaceutical carrier.

Antibacterial agents and potentiators of carbapenem antibiotics

TITLE OF THE INVENTION NOVEL ANTIBACTERIAL AGENTS AND POTENTIATORS OF CARBAPENEM ANTIBIOTICS ABSTRACT OF THE INVENTION New 3-(1-aminoalkylphosphinyl)-(2-substi-tuted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.

Benzazepinones as sodium channel blockers

Benzazepinone compounds represented by Formula (I), or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, urinary incontinence, pruritis, itchiness, allergic dermatitis, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

Improvements in steering mechanisms for motor vehicles

Apparatus and methods for manoeuvring and support of panels

A large and massive panel (12) is manoeuvred and supported by means of a work piece support (10) which has an upper horizontal work piece support surface (22) for receiving the panel in extended surface-to-surface contact. An array of apertures (24) is provided in the work piece support surface, beneath same of which are provided low friction bearing elements (28) moveable between a raised, load-bearing position in which the panel can be slid onto the work piece support and a retracted position in which the panel is left in extended surface to surface contact with the work piece support.

Phosphorous containing enzyme inhibitors

TITLE OF THE INVENTION PHOSPHORUS CONTAINING ENZYME INHIBITORS ABSTRACT OF THE DISCLOSURE Dipeptides which contain phosphorus and their pharmaceutical use and preparation are disclosed. The compounds have dehydropeptidase (DHP) enzyme inhibitor activity.

Automated storage and retrieval system

An automated system for storing and retrieving objects from multiple object categories. A plurality of storage rack assemblies is included. Each storage rack assembly has a plurality of slots sized for storing objects. A storage transport is movable alongside each respective storage rack assembly for positioning adjacent any slot. A plurality of horizontal tracks are arranged to be perpendicular to the storage rack assemblies. Each storage rack assembly has an end adjacent the tracks. A runner transport is coupled to and movable on each track for receiving one of the objects from, or providing one of the objects to a storage transport. Two conveyor rack assemblies are located at opposite ends of the tracks, aligned perpendicularly to the track. Conveyor transports are adjacent the conveyor rack assemblies for transferring objects between the conveyor rack assembly and the runner transports. Storage and retrieval operation requests are generated by simultaneously providing positioning signals to a conveyor transport, a runner transport and a storage transport. Storage transports are selected in accordance with a predetermined transport selection function. Storage slots are selected in accordance with a predetermined slot selection function. A database stores the category, age and location of each of the objects.

Biaryl substituted triazoles as sodium channel blockers