01-12-2016 дата публикации
Номер: US20160346365A1
The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells. 1121-. (canceled)122. A method of treating hemophilia B in a human subject in need thereof , comprising administering to the subject multiple doses of about 60 IU/kg to about 180 IU/kg of a long-acting Factor IX (“FIX”) polypeptide at a dosing interval of about 9 days to 18 days between two doses , wherein the long-acting FIX polypeptide comprises FIX and an FcRn binding partner (FcRn BP).123. The method of claim 122 , wherein each of the multiple doses is 60 IU/kg to 70 IU/kg claim 122 , 70 IU/kg to 80 IU/kg claim 122 , 80 IU/kg to 90 IU/kg claim 122 , 90 IU/kg to 100 IU/kg claim 122 , 100 IU/kg to 110 IU/kg claim 122 , 110 IU/kg to 120 IU/kg claim 122 , 120 IU/kg to 130 IU/kg claim 122 , or 130 IU/kg to 140 IU/kg.124. The method of claim 122 , wherein each of the multiple doses is 70 IU/kg to 80 IU/kg.125. The method of claim 122 , wherein each of the multiple doses is 90 IU/kg to 100 IU/kg.126. The method of claim 122 , wherein each of the multiple doses is 100 IU/kg to 110 IU/kg.127. The method of claim 122 , wherein each of the multiple doses is 60 IU/kg claim 122 , 65 IU/kg claim 122 , 70 IU/kg claim 122 , 75 IU/kg claim 122 , 80 IU/kg claim 122 , 85 IU/kg claim 122 , 90 IU/kg claim 122 , 95 IU/kg claim 122 , 100 IU/kg claim 122 , 105 IU/kg 110 IU/kg claim 122 , 115 IU/kg claim 122 , 120 IU/kg claim 122 , 125 IU/kg claim 122 , 130 IU/kg claim 122 , 135 IU/kg claim 122 , 140 IU/kg claim 122 , 145 IU/kg claim 122 , 150 IU/kg claim 122 , 155 IU/kg claim 122 , 160 IU/kg claim 122 , 165 IU/kg claim 122 , 170 IU/kg claim 122 , 175 IU/kg claim 122 , or 180 IU/kg.128. The method of claim ...
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