Particle compositions

PRODUCTION OF ANTIBODIES

Probiotic

Disposable, moisture vapour permeable, liquid impermeable covering sheet containing active agents

REARING CALVES

Recovery of and uses of specific binding agents

PREMIX FOR USE WITH FOODSTUFFS/VACCINES

Disposable, moisture vapour permeable, liquid impermeable covering sheet having odour reduction properties

Monitoring method

VACCINATION OF ANIMAL

PROBIOTIC

Improvements in or relating to specific binding assays

Disclosed is a method of detecting the presence of an analyte of interest in a sample, the method comprising the steps of:providing a binding partner reversibly immobilised on a solid support, said binding partner having binding specificity for the analyte;contacting the sample with the solid support;specifically displacing the binding partner from the solid support in response to the presence of the analyte of interest in the sample, said displacement causing a reduction in the mass of material immobilised on the solid support, thereby generating a detectable change in a mass-dependent property of the solid support; anddetecting said change. Also disclosed is an assay device for performing the method of the invention.

ENDOTOXINS FOR LAMB GASTRO-INTESTINAL DISORDERS

Monitoring method

A method of monitoring the ovulation cycle of a female mammal, involving regular measurement of basal body temperature throughout the cycle and occasional measurement of the level of at least one urinary component of significance in the cycle, the measurement of the metabolite being conducted at predetermined stages in the cycle to check that the level is consistent with a predicted level and thus confirm that the cycle as a whole is consistent with a prediction.

MONITORING METHOD

ANTIGENIC COMPOSITIONS

Monitoring method

CONSUMER PRODUCTS AND DELIVERY SYSTEMS UTILIZING ORGANOLEPTIC COMPOUNDS

The present application relates to perfume delivery systems and consumer products comprising a novel organoleptic compound and or perfume delivery systems having the novel organoleptic compound, as well as methods for using such perfume delivery systems and consumer products. 2. The consumer product according to claim 1 , wherein the organoleptic compound is selected from the group consisting of:(E)-1-((1R,6R)-4,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-one;(E)-1-((1S,6S)-3,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-one;(E)-1-((1R,6S)-4,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-one;(E)-1-((1S,6R)-3,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-one;(E)-1-((1R,6R)-4,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-ol;(E)-1-((1S,6S)-3,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-ol;(E)-1-((1R,6S)-4,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-ol;(E)-1-((1S,6R)-3,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-ol; anda mixture thereof.3. The consumer product according to claim 2 , wherein the organoleptic compound is the mixture of (E)-1-((1R claim 2 ,6R)-4 claim 2 ,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-one claim 2 , (E)-1-((1S claim 2 ,6S)-3 claim 2 ,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-one claim 2 , (E)-1-((1R claim 2 ,6S)-4 claim 2 ,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-one and (E)-1-((1S claim 2 ,6R)-3 claim 2 ,6-dimethylcyclohex-3-en-1-yl)-2-methylpent-1-en-3-one.4. The consumer product according to further comprising claim 1 , based on total composition weight claim 1 , from about 0.0001% to about 25% of the organoleptic compound.5. The consumer product according to claim 1 , wherein the consumer product is a fabric and/or hard surface cleaning and/or treatment composition claim 1 , said composition comprising claim 1 , based on total composition weight claim 1 , from about 0.00001% to about 25% of the organoleptic compound.6. The consumer product according to claim 1 , wherein the ...

Novel organoleptic compounds

The present invention relates to novel compounds and their use as fragrance materials.

Low ph fabric care compositions

Liquid fabric care compositions that includes vinegar and/or acetic acid; fragrance materials; and water; where the fragrance materials are characterized by a log P of less than about 2.5; and where the fabric care composition is characterized by an acidic pH. Related processes of making and using such compositions.

Specific binding assays

Disclosed is a method of detecting the presence of an analyte of interest in a sample, the method comprising the steps of: providing a binding partner reversibly immobilised on a solid support, said binding partner having binding specificity for the analyte; contacting the sample with the solid support; specifically displacing the binding partner from the solid support in response to the presence of the analyte of interest in the sample, said displacement causing a reduction in the mass of material immobilised on the solid support, thereby generating a detectable change in a mass-dependent property of the solid support; and detecting said change. Also disclosed is an assay device for performing the method of the invention.

Laundry Scent Customization

Perfume Systems

The present application relates to perfume raw materials, perfume systems and consumer products comprising such perfume raw materials and/or such perfume systems, as well as processes for making and using such, perfume systems and consumer products. The perfume compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Perfume systems

The present application relates to perfume raw materials, perfume systems and consumer products comprising such perfume raw materials and/or such perfume systems, as well as processes for making and using such, perfume systems and consumer products. The perfume compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Naphthyridin derivatives

The present invention relates to heterocyclic derivatives of formula I wherein R 1 , R 2 and R 3 are as defined in the description and claims, which compounds are metabotropic glutamate receptor 5 antagonists.

Devices for Assays

In a simultaneous marking specific binding assay for an analyte in a liquid sample, such as urine during pregnancy or fertile period test, wherein the liquid sample is simultaneously incubated with a first specific binding reagent immobilised on a solid phase carrier surface and with a second specific binding reagent dissolved or dispersed in the liquid sample and which bears a label by means of which the result of the assay can be determined, the improvement that prior to the incubation the second specific binding reagent is contained within a layer (2b) of readily soluble or dispersible solid material superimposed on the solid phase carrier surface (2a) on which the first specific binding reagent is immobilised. When the solid material dissolves or disperses in the sample liquid, the labelled reagent is released into the sample liquid at the same time as the immobilised reagent is exposed to the sample, and the close proximity of the two reagents overcomes the "hook effect" when the analyte is in high concentration in the sample.

Production of antibodies

Antibodies are produced by hyperimmunising a mammal, such as a cow, with a vaccine derived from E. coli bacteria. The bacterial strains in the vaccine are selected on the basis of their virulence characteristics, especially adhesion factors (pili), associated with gastroenteric disease in humans. The antibodies can be recovered from the mammal's milk or serum, and used in human foods.

DEVICE FOR A MOBILE RADIOTELEPHONY SYSTEM

L'INVENTION CONCERNE LES SYSTEMES DE RADIOTELEPHONIE. UN SYSTEME DE RADIOTELEPHONIE CELLULAIRE A REUTILISATION DE CANAUX ASSURE A LA FOIS UN SERVICE NORMAL ET UN SERVICE DE TYPE DISPATCHING EN LIAISON AVEC UNE FLOTTE DE VEHICULES. POUR CE DERNIER SERVICE, UNE COMMUNICATION UNIDIRECTIONNELLE 48 EST ETABLIE ENTRE UN POSTE DE DISPATCHER 39 ET UN CANAL RADIO D'ECOUTE DE FLOTTE (F, F) DANS CHAQUE REGION DE SERVICE DU SYSTEME. UNE COMMUNICATION BIDIRECTIONNELLE 46 EST ETABLIE ENTRE UN DISPATCHER ET UN OU PLUSIEURS POSTES MOBILES DE LA FLOTTE QUI REPONDENT A UN APPEL DU DISPATCHER. APPLICATION AUX SERVICES DE DISPATCHING D'UNE FLOTTE DE VEHICULES. THE INVENTION CONCERNS RADIOTELEPHONY SYSTEMS. A CELLULAR RADIOTELEPHONY SYSTEM WITH REUSE OF CHANNELS PROVIDES BOTH NORMAL SERVICE AND A DISPATCHING-TYPE SERVICE IN LINK WITH A FLEET OF VEHICLES. FOR THIS LATEST SERVICE, A ONE-WAY COMMUNICATION 48 IS ESTABLISHED BETWEEN A DISPATCHER STATION 39 AND A FLEET MONITORING RADIO CHANNEL (F, F) IN EACH SERVICE REGION OF THE SYSTEM. A TWO-WAY COMMUNICATION 46 IS ESTABLISHED BETWEEN A DISPATCHER AND ONE OR MORE MOBILE STATIONS OF THE FLEET WHICH RESPOND TO A CALL FROM THE DISPATCHER. APPLICATION TO THE DISPATCHING SERVICES OF A FLEET OF VEHICLES.

Thiazole-4-carboxyamide derivatives

The present invention is concerned with novel thiazole 4-carboxyamide derivatives of the general formula (I) and with methods for the preparation thereof, which compounds are useful as metabotropic glutamate receptor antagonists: wherein R 1 to R 4 are as defined in the specification.

Heteroaryl-substituted imidazole derivatives

Bonding shaped structures for artificial plastics

A process and apparatus for the recovery of immunoglobulines

A process and apparatus for the recovery of immunoglobulins of high purity and potency from milk, in which process milk is passed through a re-usable immunoadsorbent column comprising an insoluble carrier material to which is bound a low-affinity monoclonal antibody specific to one or more milk immunoglobulins but not specific to any other common constituent of milk, the antibody bind immunoglobulin molecules, and following removal of the residue of the milk the immunoglobulin molecules are released by eluting the immunoadsorbent. The apparatus preferably comprises two or more immunoadsorbent columns in parallel (206, 207) with means for eluting (226) each column and means for flushing (217) each column before and after elution.

Imidazol derivatives

4-[1-ARYL-IMIDAZOL-4-YLETHYNYL] -2-ALKYL-PIRIDINE AND 1-HETEROARYL-IMIDAZOL -4-YLETHNYL] -2-ALKYL-PIRIDINE DERIVATIVES AND PHARMACEUTICALLY A CCEPTABLE SALTS THEREOF FOR THE TREATMENT OR PREVENTION OF DISORDERS MEDIATED FULL OR IN PART BY METABOTROPIC GLUTAMATE RECEPTOR 5, E.G. ACUTE, TRAUMATIC AND CHRONIC DEGENERATIVE PROCESSES OF THE NERVOUS SYSTEM, SUCH AS ALZHEIMER'S DISEASE, SENILE DEMENTIA, PARKINSON'S DISEASE, HUNTINGTON'S CHOREA, AMYO-TROPIC LATERAL SCLEROSIS AND MULTIPLE SCLEROSIS, PSYCHIATRIC DISEASES SUCH AS SCHIZOPHRENIA AND ANXIETY, DEPRESSION, PAIN AND DRUG DEPENDENCY.

Pyridine-2-carboxamide derivatives as mG1uR5 antagonists

Cellular high capacity mobile radiotelephone system with fleet-calling arrangement for dispatch service

A high capacity, cellular, channel reuse, mobile, radiotelephone system supplies both nondispatch radiotelephone service and dispatch service with a fleet-calling capability. For the latter capability, unidirectional communication (48) is provided from a dispatcher station (39) to a fleet-listen radio channel (f FC10 , f FC20 ) in each service region of the system where idle fleet mobile units are located. Bidirectional communication (46) is provided between one or more responding fleet units and a fleet dispatcher, and such communication is also applied to the fleet-listen channels.

Extendible flexible electrical conduit with conductors therein

An extendible flexible electrical conduit with a telescoping section connected between two spiral gooseneck sections and having insulated electrical conductors extending through the conduit. The conductors are helically wound inside the inner tube of the telescoping section so as to allow them to extend and contract to accommodate extension and contraction of the telescoping section. The outer tube of the telescoping section is oval along most of its length and the sliding end of the inner tube is also oval. The length of the telescoping section may be locked by rotating the inner tube with respect to the outer tube.

Imidazole derivatives

The present invention relates to imidazole derivatives of formula I wherein R 1 , R 2 , R 3 , R 4 , X, Y and R are described hereinabove, or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the imidazole derivatives of formula I, a process for preparing a compound of formula I, and a method of treating or preventing acute and/or chronic neurological disorder comprising administering to a patient in need of such treatment and/or prevention a therapeutically effective amount of said pharmaceutical composition. These disorders include Alzheimer's disease. These disorders also include mild cognitive impairment.

Imidazole derivatives

The present invention relates to imidazole derivatives of formula I wherein R 1 , R 2 , R 3 and R 4 are described hereinabove. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognititve disorders and memory deficits, as well as chronic and acute pain.

Phenol formaldehyde resin-glycinin protein emulsion

Disposable moisture vapour permeable, liquid impermeable covering sheet for bedding articles containing active agents

The present invention relates to a disposable covering sheet which is moisture vapour permeable and liquid impermeable and contains active agent or agents. The disposable covering sheet comprises at least a moisture vapour permeable layer and a liquid impermeable but moisture vapour permeable film layer of thermoplastic compositions. The disposable covering sheet such as, for example, a mattress cover or a pillow cover gives a better comfort to the user by providing active agent releasing properties. The disposable covering sheet of the present invention can find a variety of applications wherein moisture vapour permeability and liquid imperviousness combined with long lasting active agent releasing properties are desirable.

Perfume systems

The present application relates to perfume raw materials, perfume systems and consumer products comprising such perfume raw materials and/or such perfume systems, as well as processes for making and using such, perfume systems and consumer products. The perfume compositions, including the delivery systems, disclosed herein expand the perfume communities options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Consumer products and delivery systems utilizing organoleptic compounds

The present application relates to perfume delivery systems and consumer products comprising a novel organoleptic compound and or perfume delivery systems having the novel organoleptic compound, as well as methods for using such perfume delivery systems and consumer products.

Bulb outage indicator for multi-lamp circuits

A bulb outage indicator in conjunction with a vehicle turn signal flasher circuit. The flasher circuit includes a relay periodically energized and deenergized to control a set of normally open contacts to supply current from a source to the turn signal lamps. The relay also includes a second set of normally open contacts in series with the source, a set of normally closed contacts, and an indicating lamp. The set of normally closed contacts is controlled by a current sensitive coil in series with the vehicle turn signal lamps. The current sensitive coil is sensitive to the total current supplied to the lamps when all the lamps are operating and is insensitive to the current supplied to the lamps when one or more of the lamps have failed. When one of the turn signal lamps has failed, the set of normally closed relay contacts remains closed and the two sets of normally open relay contacts periodically flash the remaining turn signal lamps and the indicator lamp to indicate a lamp failure.

Pyridine-2-carboxamide derivatives as mglur5 antagonists

The invention relates to compounds of formula (I) wherein R1 to R3 are as defined in the description and claims, to processes for their preparation, pharmaceutical compositions containing them, and uses thereof for the preparation of medicaments useful for treating CNS disorders.

Zoned mobile radio telephone system

A process and apparatus for the recovery of immunoglobulins

PCT No. PCT/GB82/00060 Sec. 371 Date Sep. 22, 1982 Sec. 102(e) Date Sep. 22, 1982 PCT Filed Feb. 24, 1982 PCT Pub. No. WO82/02818 PCT Pub. Date Sep. 2, 1982.A process for the recovery of immunoglobulins of high purity and potency from milk, in which process milk is passed through a re-usable immunoadsorbent column comprising an insoluble carrier material to which is bound a low-affinity monoclonal antibody specific to one or more milk immunoglobulins but not specific to any other common constituent of milk, the antibody bind immunoglobulin molecules are released by eluting the immunoadsorbent.

Thiazole-4-carboxamide derivatives as mglur5 antagonists

The present invention is concerned with novel thiazole 4-carboxyamide derivatives of the general formula (I) and with methods for the preparation thereof, which compounds are useful as metabotropic glutamate receptor antagonists: wherein R1 to R4 are as defined in the specification.

Disposable, moisture vapour permeable, liquid impermeable covering sheet having odour reduction properties

The present invention relates to a disposable covering sheet which is moisture vapour permeable and liquid impermeable and has odour control properties and, if desired, also active agent releasing properties. The disposable covering sheet comprises at least a moisture vapour permeable layer and a liquid impermeable but moisture vapour permeable film layer of thermoplastic compositions. The disposable covering sheet such as, for example, a mattress cover or a pillow cover gives a better comfort to the user by providing odour control properties and, if desired, also active agent releasing properties. The disposable covering sheet of the present invention can find a variety of applications wherein moisture vapour permeability and liquid imperviousness combined with specific odour control properties and preferably also active agent releasing properties are desirable.

Antigenic compositions

ABSTRACT A vaccine comprising an antigen selectively adsorbed onto erythrocytes possessing their natural surface characteristics. When the antigen is the K88a,b/adhesion factor of E. coli and the erythrocytes are chicken erythrocytes, the vaccine is especially suitable for reducing the incidence of neonatal diarrhoea in pigs if it is administered parenterally to a sow about three weeks prior to parturition.

Imidazole derivatives III

Pyridine-2-carboxamide derivatives as mglur5 antagonists.

La invencion se refiere a los compuestos de la formula I (ver formula (I)): en la que R1 a R3 son tal y como se ha definido en la descripcion y en las reivindicaciones, para los procesos de su preparacion, los cuales estan dentro de las composiciones farmaceuticas, y usa los mismos para la preparacion de los medicamentos utiles para tratar los trastornos del SNC.

METHOD AND DEVICE FOR RECOVERING IMMUNOGLOBULINES.

PCT No. PCT/GB82/00060 Sec. 371 Date Sep. 22, 1982 Sec. 102(e) Date Sep. 22, 1982 PCT Filed Feb. 24, 1982 PCT Pub. No. WO82/02818 PCT Pub. Date Sep. 2, 1982.A process for the recovery of immunoglobulins of high purity and potency from milk, in which process milk is passed through a re-usable immunoadsorbent column comprising an insoluble carrier material to which is bound a low-affinity monoclonal antibody specific to one or more milk immunoglobulins but not specific to any other common constituent of milk, the antibody bind immunoglobulin molecules are released by eluting the immunoadsorbent.

Priobiotic containing enterococcus faecium strain NCIMB 40371

A strain of Enterococcus faecium, deposited as NCIMB 40371, has valuable probiotic properties and is particularly effective in alleviating symptoms of irritable bowel syndrome (IBS) in human patients. The strain can be used in the manufacture of human foodstuffs.

Ball catching device

Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists

Perfume systems

The present application relates to perfume raw materials, perfume systems and consumer products comprising such perfume raw materials and/or such perfume systems, as well as processes for making and using such, perfume systems and consumer products. The perfume compositions, including the delivery systems, disclosed herein expand the perfume communities options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Pyridine-2-carboxamide derivatives as mglur5 antagonists

The invention relates to compounds of formula (I) wherein R1 to R3 are as defined in the description and claims, to processes for their preparation, pharmaceutical compositions containing them, and uses thereof for the preparation of medicaments useful for treating CNS disorders.

Improvements in or relating to specific binding assays

Disclosed is a method of detecting the presence of an analyte of interest in a sample, the method comprising the steps of: contacting the sample with a sol id support having reversibly immobilised thereon either a binding partner havin g specific binding affinity for the analyte, or an analogue of the analyte; an d detecting a reduction in the mass of material immobilised on the solid support, said binding partner or analogue being specifically displaced from the solid support in the presence of the analyte of interest, so as to cause a detectable change in the mass of material immobilised thereon. Also disclose d is a device for performing the method.

DERIVATIVES OF TIAZOL-4-CARBOXAMIDE AS ANGLGIST OF MGLUR5

La presente se refiere a derivados de tiazol-4-carboxamida de la formula general (1) y a métodos para la obtencion de los mismos, dichos compuestos son utiles como antagonistas de receptor metabotropico de glutamato. Reivindicacion 1: Compuestos de la formula (1) en la que R1 es arilo o heteroarilo, que están opcionalmente sustituidos por uno o varios -OH, Cl, F, Br, ciano, alquilo C1-7, alcoxi C1-7, -O-(CO)-alquilo C1-7, cicloalquilo C3-6, -(CH2)m-Ra, en el que Ra es -OH, -CH2F, -CHF2, -CF3, - alcoxi C1-7, cicloalquilo C3-6, -NH(CO)-alquilo C1-7, u -O-(CO)-alquilo C1-7; R2 es H, alquilo C1-7, -(CH2)m-O-alquilo C1-7 o cicloalquilo C3-6; R3 es alquilo C1-7, -(CH2)m-Rb, en el que Rb es -O-alquilo C1-7, cicloalquilo C3-6, heterocicloalquilo de 5 o 6 eslabones, arilo opcionalmente sustituido por F, o heteroarilo opcionalmente sustituido por alquilo C1-7; -(CO)-Rc, en el que Rc es - O-(CH2)m-cicloalquilo C3-6, o arilo; cicloalquilo C3-6; o heterocicloalquilo de 5 o 6 eslabones; o arilo o heteroarilo que están opcionalmente sustituidos por: ciano, Cl, F, Br, CF3, CHF2, cicloalquilo C3-6, u -O-alquilo C1-7; o -(CO)-Rd, en el que Rd es alquilo C1-7, NH2, u -O-alquilo C1-7; o -(CH2)m-Re, en el que Re es OH, alcoxi C1-7, CHF2, CF3, NH2, - NH-(CO)-alquilo C1-7; -NH-(CO)-O- alquilo C1-7; o -NH-(CO)-alquilo C1-7; u -O-CH2F, -O-CHF2, -O-CF3; o -S(O)2-Rf, en el que Rf es alquilo C1-7, -NH2, -NH-alquilo C1-7 o -N-di(alquilo C1-7), o heteroarilo opcionalmente sustituido por alquilo C1-7; R4 es H, alquilo C1-7 o (alquil C1-7)-cicloalquilo C3-6; m es un numero de 1 a 4; así como a las sales farmacéuticamente aceptables de los mismos. This refers to thiazol-4-carboxamide derivatives of the general formula (1) and to methods for obtaining them, said compounds are useful as glutamate metabotropic receptor antagonists. Claim 1: Compounds of the formula (1) wherein R1 is aryl or heteroaryl, which are optionally substituted by one or more -OH, Cl, F, Br, cyano, C1-7 alkyl, C1-7 alkoxy, -O - ...

Extendible flexible electrical conduit with conductors therein

An extendible flexible electrical conduit (10) with a telescoping section (16) connected between two spiral gooseneck sections (12, 14) and having insulated electrical conductors (32) extending through the conduit. The conductors are helically wound inside the inner tube (18) of the telescoping section so as to allow them to extend and contract to accommodate extension and contraction of the telescoping section. The outer tube (20) of the telescoping section is oval along most of its length and the sliding end (42) of the inner tube is also oval. The length of the telescoping section may be locked by rotating the inner tube with respect to the outer tube.

Enterococcus organisms and their use as probiotics in alleviating irritable bowel syndrome symptoms

A novel strain of Enterococcus faecium, deposited as NCIMB 40371, has valuable probiotic properties and is particularly effective in alleviating symptoms of irritable bowel syndrome in human patients. The novel strain can be used in the manufacture of human foodstuffs.

Food manufacture

Abstract The invention provides a process for the preparation of a pre-mix in the form of a free-flowing particulate composition in which a minor but essential foodstuff ingredient such as an oral vaccine, a vitamin or a trace element is dispersed uniformly throughout a carrier material which forms the bulk of the pre-mix, in which the carrier material comprises a dry particulate mixture of an edible inert powder and a lactose source, the lactose content of the mixture having from about 20 to about 50% by weight, and the pre-mix is formed by intensely agitating the carrier material and simultane-ously spraying the carrier material with an aqueous solution or slurry of the foodstuff ingredient, the solution or slurry being applied in an amount from about 1 to about 12% by weight of the carrier material. Preferably the solution or slurry applied to the carrier material additionally contains a food-grade colouring agent.

Cellular mobile radiotelephony system

Heteroaryl-substituted imidazole derivatives

THE PRESENT INVENTION RELATES TO IMIDAZOLE DERIVATIVES OF THE GENERAL FORMULA I WHEREIN R¹,R², R³AND R⁴ ARE AS DEFINED IN THE SPECIFICATION AS WELL AS TO PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND TO PROCESSES FOR THE PREPARATION THEREOF. THE INVENTION ALSO RELATES TO THE USE OF SAID IMIDAZOLE DERIVATIVES FOR THE PREPARATION OF MEDICAMENTS AND TO MEDICAMENTS CONTAINING THEM FOR THE PREVENTION OR THE TREATMENT OF MGLUR5 RECEPTOR MEDIATED DISORDERS, SUCH AS ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS, IN PARTICULAR ANXIETY, OR FOR THE TREATMENT OF CHRONIC AND ACUTE PAIN.

Pyridine-2-carboxamide derivatives as antagonists of MGLUR5

Los compuestos de la fórmula general (I)**Fórmula** en la cual R1 es un anillo de 5- o 6- miembros respectivamente de las fórmulas (II) y (III): R2 es H, C1-C7-alquilo, C3-C6-cicloalquilo -(CH2)m-Ra; R3 es arilo o heteroarilo qu 45 e son opcionalmente sustituidos por: CN, Cl, F, Br, CF3, CHF2, o -O-C1-C7-alquilo, -(CO)-Rb, -(CH2)m-Rc, -NH-(CO)-C1-C7-alquilo; -O-CH2F, -OCHF2, -O-CF3, -S(O)2-Rd, C3-C6-cicloalquilo heteroarilo que es opcionalmente sustituido por C1-C7-alquilo; R4 es H, -OH, Cl, F, Br, CN, -CHF2, CF3, C1-C7-alquilo, -O-(CO)-C1-C7-alquilo, C3-C6-cicloalquilo, o -(CH2)m-Re; R5 es C1-C7-alquilo o C1-C7-alquil-C3-C6-cicloalquilo; -(CH2)n-O-Rf, C3-C8-alquenil-O-Rf, -(CH2)n-NRgRh; -C2-C6- alquenil-NRgRh o -(CH2)n-Re; Ra es -O-C1-C7-alquilo o -OH; Rb es C1-C7-alquilo, NH2, o -O-C1-C7-alquilo; Rc es -OH, NH2, o NH-(CO)-O-C1-C7-alquilo; Rd es C1-C7-alquilo, -NH2, -NH-C1-C7-alquilo o -N-di(C1-C7-alquil); Re es -OH, -CH2F, -CHF2, -CF3 o -O-(CO)-C1-C7-alquilo; Rf es C1-C7-alquilo, C3-C8-alquenilo, C3-C6-cicloalquilo, fenilo, bencilo o -(CO)-R'; Rg, Rh son, independientemente, H, C1-C7-alquilo, C3-C6-cicloalquilo, C3-C8-alquenilo, fenilo, bencilo, o -(CO)-R' o Rg y Rh también, junto con el átomo de nitrógeno al que están unidos, pueden formar un anillo heteroarilo o heterocíclico de 5- hasta 7- miembros que opcionalmente se pueden sustituir con 1 o 2 OH; R' es NH2, -NH-C1-C7-alquilo, C1-C7-alquilo o C1-C7-alcoxi; m es 1 a 4; n es 2 a 6; así como sus sales aceptadas farmacéuticamente. Compounds of the general formula (I) ** Formula ** in which R1 is a 5- or 6- member ring respectively of formulas (II) and (III): R2 is H, C1-C7-alkyl, C3-C6-cycloalkyl - (CH2) m-Ra; R3 is aryl or heteroaryl qu45 and are optionally substituted by: CN, Cl, F, Br, CF3, CHF2, or -O-C1-C7-alkyl, - (CO) -Rb, - (CH2) m-Rc, -NH- (CO) -C1-C7-alkyl; -O-CH2F, -OCHF2, -O-CF3, -S (O) 2-Rd, C3-C6-cycloalkyl heteroaryl which is optionally substituted by C1-C7-alkyl; R4 is H, -OH, Cl, F, ...

PROCEDURE FOR PREPARING A PREPARATION FOR FEED USE

Consumer products and delivery systems utilizing organoleptic compounds

The present application relates to perfume delivery systems and consumer products comprising a novel organoleptic compound and or perfume delivery systems having the novel organoleptic compound, as well as methods for using such perfume delivery systems and consumer products.

Method and apparatus for monitoring the ovulation cycle

A method of monitoring the ovulation cycle of a female mammal, involving regular measurement of basal body temperature throughout the cycle and occasional measurement of the level of at least one urinary component of significance in the cycle, the measurement of the metabolite being conducted at predetermined stages in the cycle to check that the level is consistent with a predicted level and thus confirm that the cycle as a whole is consistent with a prediction.

IMIDAZOLE DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS

L'invention concerne des dérivés imidazole qui sont des antagonistes du récepteur mGluR5, et qui sont représentés par la formule générale (I): dans laquelle R1, R2, R3 et R4 sont tels que définis dans le descriptif, un procédé permettant de produire ces dérivés, ainsi que des sels pharmaceutiquement acceptables servant à la préparation d'un médicament destiné au traitement ou à la prévention de troubles dans lesquels le récepteur mGluR5 intervient comme médiateur, tels que les troubles neurologiques aigus et/ou chroniques. The invention relates to imidazole derivatives which are mGluR5 receptor antagonists, and which are represented by the general formula (I): wherein R1, R2, R3 and R4 are as defined in the specification, a process for producing these derivatives, as well as pharmaceutically acceptable salts for the preparation of a medicament for the treatment or prevention of disorders in which the mGluR5 receptor mediates, such as acute and / or chronic neurological disorders.

Thiazole-4-carboxamide derivatives as mglur5 antagonists

The present invention is concerned with novel thiazole 4-carboxyamide derivatives of the general formula (I) and with methods for the preparation thereof, which compounds are useful as metabotropic glutamate receptor antagonists: wherein R1 to R4 are as defined in the specification.

IMPROVEMENTS IN OR WITH REGARD TO SPECIFIC BINDING ASSAYS

Disclosed is a method of detecting the presence of an analyte of interest in a sample, the method comprising the steps of:providing a binding partner reversibly immobilised on a solid support, said binding partner having binding specificity for the analyte;contacting the sample with the solid support;specifically displacing the binding partner from the solid support in response to the presence of the analyte of interest in the sample, said displacement causing a reduction in the mass of material immobilised on the solid support, thereby generating a detectable change in a mass-dependent property of the solid support; anddetecting said change. Also disclosed is an assay device for performing the method of the invention.

Novel organoleptic compounds

The present invention relates to novel compounds and their use as fragrance materials.

Article for polishing

Thiazole-4-carboxamide derivatives as mglur5 antagonists.

La presente invencion se refiere a nuevos derivados de tiazol-4-carboxamida de la formula general (I) y a metodos para la obtencion de los mismos, caracterizados porque los compuestos son utiles como antagonistas de receptor metabotropico de glutamato, en donde R1 a R4 tienen los significados definidos en la especificacion.

Pyridine-2-carboxamide derivatives as mglur5 antagonists

METHOD AND DEVICE FOR MONITORING THE OVULATION CYCLE

A method of monitoring the ovulation cycle of a female mammal, involving regular measurement of basal body temperature throughout the cycle and occasional measurement of the level of at least one urinary component of significance in the cycle, the measurement of the metabolite being conducted at predetermined stages in the cycle to check that the level is consistent with a predicted level and thus confirm that the cycle as a whole is consistent with a prediction.

Thiazolo[4,5-C]pyridine derivatives

Imidazole derivatives

Zoned mobile radio telephone system

Imidazole derivatives III

RECOVERY AND USE OF SPECIFIC BINDING REAGENTS

An antibody specific for a target analyte is purified by affinity chromatography on a substrate bearing a low-affinity analogue of the target analyte. The antibody is displaced from the substrate by contact with a second analogue of intermediate affinity, which remains complexed with the antibody. This complex can be used in a conventional assay for the target analyte, which displaces the intermediate-affinity analogue. The complexed antibody is rendered more storage-stable because the second analogue protects the antibody binding reagion.

Process and apparatus for carrying out specific binding assays

An immunoassay for an analyte is disclosed in which (a) sample, (b) an immobilized specific binding partner for the analyte and (c) the specific binding partner for the analyte conjugated to a detectable marker are reacted together in a single step. Competitive interference of the reagents is avoided by using reagent (c) in a slow-release form as a glaze coated on a surface in contact with the reaction liquid.

Disposable, moisture vapour permeable, liquid impermeable covering sheet having odour reduction properties

The present invention relates to a disposable covering sheet which is moisture vapour permeable and liquid impermeable and has odour control properties and, if desired, also active agent releasing properties. The disposable covering sheet comprises at least a moisture vapour permeable layer and a liquid impermeable but moisture vapour permeable film layer of thermoplastic compositions. The disposable covering sheet such as, for example, a mattress cover or a pillow cover gives a better comfort to the user by providing odour control properties and, if desired, also active agent releasing properties. The disposable covering sheet of the present invention can find a variety of applications wherein moisture vapour permeability and liquid imperviousness combined with specific odour control properties and preferably also active agent releasing properties are desirable.

IMPROVEMENTS IN OR WITH REGARD TO SPECIFIC BINDING ASSAYS

Disclosed is a method of detecting the presence of an analyte of interest in a sample, the method comprising the steps of:providing a binding partner reversibly immobilised on a solid support, said binding partner having binding specificity for the analyte;contacting the sample with the solid support;specifically displacing the binding partner from the solid support in response to the presence of the analyte of interest in the sample, said displacement causing a reduction in the mass of material immobilised on the solid support, thereby generating a detectable change in a mass-dependent property of the solid support; anddetecting said change. Also disclosed is an assay device for performing the method of the invention.

Process for the recovery of immunoglobulins

A process for the recovery of immunoglobulins of high purity and potency from milk, in which process milk is passed through a re-usable immunoadsorbent column comprising an insoluble carrier material to which is bound a low-affinity monoclonal antibody specific to one or more milk immunoglobulins but not specific to any other common constituent of milk, the antibody bind immunoglobulin molecules are released by eluting the immunoadsorbent.

Consumer products and delivery systems utilizing organoleptic compounds

The present application relates to perfume delivery systems and consumer products comprising a novel organoleptic compound and or perfume delivery systems having the novel organoleptic compound, as well as methods for using such perfume delivery systems and consumer products.

Consumer products and delivery systems utilizing organoleptic compounds

Bonding shaped structures of artificial plastics

Rückgewinnung und verwendungen von spezifischen bindungsreagenzen

Design for a fishing bait

Novel organoleptic compounds

The present invention relates to novel compounds and their use as fragrance materials.

Verbesserungen in oder in bezug auf spezifische bindungsassays

Resinous composition

Fremgangsmaade til fremstilling af et middel til forhindring af gastro-intestinale forstyrrelser hos svin

Synthetic resin and method of producing same

Compositions comprising a meta-(c1-c4 alkoxy) salicylaldehyde

Compositions, such as consumer products and/or fragrance/flavoring compositions, that include a meta-(C1-C4 alkoxy)salicylaldehyde, such as ortho-ethylvanillin. Processes of making and using such compositions.

Improved cultivator

低ｐＨ布地ケア組成物

【課題】酢を含有し、許容可能な安定性及び嗅覚特性を特徴とする液体布地ケア組成物を提供する。【解決手段】液体布地ケア組成物であって、酢及び／又は酢酸と、クエン酸、乳酸、アジピン酸等の第２の有機酸と、芳香物質と、水とを含み、芳香物質は、ｌｏｇＰが２．５以下であることを特徴とし、布地ケア組成物は、酸性ｐＨであることを特徴とする、液体布地ケア組成物。このような組成物を製造し、使用する関連方法。【選択図】なし

Low ph fabric care compositions

Productos de consumo y sistemas de suministro que utilizan compuestos organolépticos

La presente solicitud se refiere a sistemas de administración de perfume y productos de consumo que comprenden un nuevo compuesto organoléptico y/o sistemas de administración de perfume que tienen el nuevo compuesto organoléptico, así como a métodos para usar dichos sistemas de administración de perfume y productos de consumo. (Traducción automática con Google Translate, sin valor legal)

Compositions comprising a meta-(c1-c4 alkoxy)salicylaldehyde

Compositions, such as consumer products and/or fragrance/flavoring compositions, that include a meta-(C1-C4 alkoxy)salicylaldehyde, such as ortho-ethylvanillin. Processes of making and using such compositions.

Artificial leg

Dipper tooth

Compositions comprising a meta-(c1-c4 alkoxy) salicylaldehyde

Compositions, such as consumer products and/or fragrance/flavoring compositions, that include a meta-(C1-C4 alkoxy)salicylaldehyde, such as ortho-ethylvanillin. Processes of making and using such compositions.

Process of newsprinting

Method for monitoring ovulation

A method of monitoring the ovulation cycle of a female mammal, involving regular measurement of basal body temperature throughout the cycle and occasional measurement of the level of at least one urinary component of significance in the cycle, the measurement of the metabolite being conducted at predetermined stages in the cycle to check that the level is consistent with a predicted level and thus confirm that the cycle as a whole is consistent with a prediction.

Monitoring method

A method of monitoring the ovulation cycle of a female mammal, involving regular measurement of basal body temperature throughout the cycle and occasional measurement of the level of at least one urinary component of significance in the cycle, the measurement of the metabolite being conducted at predetermined stages in the cycle to check that the level is consistent with a predicted level and thus confirm that the cycle as a whole is consistent with a prediction.

Procedimiento y aparato para vigilar el ciclo ovulatorio.

UN METODO DE MONITORIZACION DEL CICLO DE OVULACION DE UN MAMIFERO HEMBRA, COMPRENDIENDO LA MEDICION REGULAR DE LA TEMPERATURA BASAL DEL CUERPO A TRAVES DEL CICLO Y MEDICION OCASIONAL DEL NIVEL DE, POR LO MENOS, UN COMPONENTE URINARIO DE SIGNIFICACION EN EL CICLO, REALIZANDOSE LA MEDICION DEL METABOLITO EN ETAPAS PREVIAMENTE DETERMINADAS EN EL CICLO, PARA COMPROBAR QUE EL NIVEL ES COMPATIBLE CON UN NIVEL PREVISTO, Y ASI CONFIRMAR QUE EL CICLO, COMO UN TODO, ES COMPATIBLE CON UNA PREDICCION.

Process for conducting an organic reaction in ionic liquids

The present disclosure describes processes for producing cyclohexenes using Lewis acidic ionic liquids comprising the steps of providing to a reactor an α,β-unsaturated carbonyl dienophile, providing to the reactor a 1,3-diene, providing a Lewis acidic ionic liquid to the reactor; and reacting the α,β-unsaturated carbonyl dienophile with 1,3-diene to form a substituted cyclohexene product. The α,β-unsaturated carbonyl dienophile can be mesityl oxide, the 1,3-diene can be piperylene; and the Lewis acidic ionic liquid can be AlCl 3 :[C 2 mim]Cl; AlCl 3 :[C 8 mim]Cl; or mixtures thereof.

Processes for epimerizing cyclohexenyl ketones with subsequent aldol condensation to produce fragrance compounds

The present disclosure describes processes for the epimerization of a cyclohexene comprising the steps of providing to a reactor a first isomer of a 1-(2-alkyl-3-cyclohexen-1-yl)-alkanone compound according to Formula I I wherein R1 ad R2 are each independently C1-C4 alkyl, and R3, R4, R5, R6, R7, and R8 are each independently selected from the group consisting of H and C1-C4 alkyl; and epimerizing the first isomer of the 1-(2-alkyl-3-cyclohexen-1-yl)-alkanone with a metal alkoxide base to form a second isomer of the 1-(2-alkyl-3-cyclohexen-1-yl)-alkanone.

Detergent compositions

Detergent compositions can include a surfactant; cloudiness causing perfume ingredient; and octanoic acid, nonanoic acid, decanoic acid, or a combination thereof. Also included are methods of solubilizing cloudiness causing perfume ingredients.

Detergent compositions

Detergent compositions can include a surfactant; cloudiness causing perfume ingredient; and octanoic acid, nonanoic acid, decanoic acid, or a combination thereof. Also included are methods of solubilizing cloudiness causing perfume ingredients.

Compositions comprising adamantyl ester-containing compounds

Compositions, such as consumer products and/or fragrance compositions, that include an adamantyl ester-containing compound.