3-SUBSTITUTIERTE-2 (ARYL ALKYL) - 1-AZABICYCLOALKAN AND METHODS TO THEIR USE

PYRROLE DERIVATIVES AS LIGANDS OF MELANOCORTIN RECEPTORS

(2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofurn-2-carboxamide, novel salt forms, and methods of use thereof

The present invention relates to (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems.

(2S,3R)-N-(2((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide novel salt forms, and methods of use thereof

The present invention relates to (2S,3R)N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems.

(2S,3R)-N-2-3-PYRIDINYLMETHYL-1-AZABICYCLO 2.2.2 OCT-3-YL BENZOFURAN-2-CARBOXAMIDE, NOVEL SALT FORMS, AND METHODS OF USE THEREOF

The present invention relates to (2S,3R)N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems.

(2S,3R)-N-(2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)BENZYOFURN-2-CARBOXAMIDE, NOVEL SALT FORMS, AND METHODS OF USE THEREOF

The present invention relates to (2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems. 1. A method for treating one or more of mild cognitive impairment , age-associated memory impairment , pre-senile dementia , early onset Alzheimer's disease , senile dementia , dementia of the Alzheimer's type , or Alzheimer's disease comprising administering a compound (2S ,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide or a pharmaceutically acceptable salt thereof , substantially free of (2S ,3S)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide , (2R ,3S)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide , (2R ,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide , and pharmaceutically acceptable salts thereof.2. The method of claim 1 , wherein the treatment is for Alzheimer's disease.3. The method of claim 1 , wherein the treatment is for early onset Alzheimer's disease. The present invention is a continuation of U.S. patent application Ser. No. 13/116,080, filed May 26, 2011, which is a continuation of U.S. patent application Ser. No. 12/184,312, filed Aug. 1, 2008, now U.S. Pat. No. 7,981,906 issued Jul. 19, 2011, which claims benefit to U.S. Provisional Application Nos. 60/971,654, filed Sep. 12, 2007, 60/953,610, filed Aug. 2, 2007, 60/953,613, filed Aug. 2, 2007, and 60/953,614 filed Aug. 2, 2007, each of which is incorporated herein by reference in its entirety.The present invention relates to (2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating ...

(2S,3R)-N-(2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)BENZOFURN-2-CARBOXAMIDE, NOVEL SALT FORMS, AND METHODS OF USE THEREOF

The present invention relates to (2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems. 1. A compound (2S ,3R)N-(2-((3-pyridinyl)methyl-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide or a pharmaceutically acceptable salt thereof , substantially free of (2S ,3S)N-(2-((3-pyridinyl)methyl-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide or a pharmaceutically acceptable salt thereof , (2R ,3S)N-(2-((3-pyridinyl)methyl-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide or a pharmaceutically acceptable salt thereof , or (2R ,3R)N-(2-((3-pyridinyl)methyl-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide or a pharmaceutically acceptable salt thereof.2. A method for treating or preventing a central nervous system disorder claim 1 , inflammation claim 1 , pain claim 1 , or neovascularization comprising administering the compound of .3. The method of claim 2 , wherein the central nervous system disorder is selected from mild cognitive impairment claim 2 , age-associated memory impairment claim 2 , pre-senile dementia claim 2 , early onset Alzheimer's disease claim 2 , senile dementia claim 2 , dementia of the Alzheimer's type claim 2 , Alzheimer's disease claim 2 , Lewy Body dementia claim 2 , micro-infarct dementia claim 2 , AIDS-related dementia claim 2 , HIV-dementia claim 2 , multiple cerebral infarcts claim 2 , Parkinsonism claim 2 , Parkinson's disease claim 2 , Pick's disease claim 2 , progressive supranuclear palsy claim 2 , Huntington's chorea claim 2 , tardive dyskinesia claim 2 , hyperkinesia claim 2 , mania claim 2 , attention deficit disorder claim 2 , attention deficit hyperactivity disorder claim 2 , anxiety claim 2 , depression claim 2 , dyslexia claim 2 , schizophrenia claim 2 , ...

Methods and Systems for Maintaining Diversity for Telecommunications Services

Diversity among telecommunications circuits is maintained by analyzing factors including whether synchronization leads are shared by diverse circuits, whether violations of diversity are brought about by new orders that have been placed, and whether improper personnel have been assigned to monitor diverse circuits. Diversity is further maintained by reporting within a graphical user interface those circuits that are subject to diversity and reporting violations of diversity that exist for those circuits. The graphical user interface may provide various controls for dictating which violations are displayed for which circuits. Additionally, diversity is maintained by providing search options that allow the circuits subject to diversity to be narrowed depending upon user-specified criteria. 1. A computer readable storage medium containing instructions which , when executed by a processor , cause the processor to perform operations comprising:monitoring an external system to detect new orders for circuits other than a first circuit and a second circuit of a diverse pair, wherein the new orders result in changes to the associations of items of equipment to the first circuit and the second circuit of the diverse pair, and to detect whether the changes resulting from the detected new orders create an association of a first item of equipment to both the first circuit and the second circuit of the diverse pair;responsive to a detected new order resulting in a change that creates an association of the first item of equipment to both the first circuit and the second circuit of the diverse pair, outputting an indicator;presenting for display a list of the plurality of telecommunications circuits and a control for each circuit in the list to show circuit details;receiving a selection of a first control for the first circuit of the diverse pair;responsive to receiving the selection of the first control, presenting for display a list of the items of equipment that are associated ...

(2S,3R)-N-2-3-PYRIDINYLMETHYL-1-AZABICYCLO 2.2.2 OCT-3-YL BENZOFURAN-2-CARBOXAMIDE, NOVEL SALT FORMS, AND METHODS OF USE THEREOF

The present invention relates to (2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems. 1. A method for treating a neurodegenerative disorder comprising administering a compound (2S ,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide or a pharmaceutically acceptable salt thereof , substantially free of (2S ,3S)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide , (2R ,3S)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide , (2R ,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide , and pharmaceutically acceptable salts thereof.2. The method of claim 1 , wherein the treatment is for dementia.3. The method of claim 1 , wherein the treatment is for ataxia. The present invention is a continuation of U.S. patent application Ser. No. 13/947,157 filed Jul. 22, 2013, which is a continuation of U.S. patent application Ser. No. 13/116,080, filed May 26, 2011, now U.S. Pat. No. 8,541,446, issued Sep. 24, 2013, which is a continuation of U.S. patent application Ser. No. 12/184,312, filed Aug. 1, 2008, now U.S. Pat. No. 7,981,906 issued Jul. 19, 2011, which claims benefit to U.S. Provisional Application Nos. 60/971,654, filed Sep. 12, 2007, 60/953,610, filed Aug. 2, 2007, 60/953,613, filed Aug. 2, 2007, and 60/953,614 filed Aug. 2, 2007, each of which is incorporated herein by reference in its entirety.The present invention relates to (2S,3R)—N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated ...

Blend of polyacrylic and polyvinyl acetate latexes

The present invention is a composition comprising a blend of a PVA based latex and an EA/MMA based polyacrylic latex. The composition of the present invention is useful in a paint formulation for providing a coating with superior scrub resistance over a formulation comprising a blend of a PVA based latex and a BA/MMA based polyacrylic latex.

COMPOSITIONS AND METHODS FOR PREVENTING TUMORS AND CANCER

Provided are methods for preventing initiation and/or progression of gastrin-associated tumors and/or cancers in subjects. In some embodiments, the methods relate to administering compositions that gastrin immunogens to subjects. Also provided are methods for inhibiting development of gastrin-associated precancerous lesions, methods for preventing formation of fibrosis associated with a tumor and/or a cancer, uses of compositions that include a gastrin immunogen to prevent initiation and/or development of a gastrin-associated tumor or cancer and/or for preparing medicaments therefor, and compositions for use in preventing initiation and/or development of gastrin-associated tumors and/or cancers and/or precancerous lesions thereof. 1. A method for preventing initiation or progression of a gastrin-associated tumor or cancer in a subject , the method comprising:(a) providing a subject at risk for developing a gastrin-associated tumor or cancer; and(b) administering to the subject a composition comprising a gastrin immunogen, wherein the gastrin immunogen induces an anti-gastrin humor and/or cellular immune response in the subject sufficient to prevent initiation or progression of a gastrin-associated tumor or cancer in the subject.2. The method of claim 1 , wherein the gastrin immunogen comprises a gastrin peptide claim 1 , optionally a gastrin peptide comprising claim 1 , consisting essentially of claim 1 , or consisting of an amino acid sequence selected from the group consisting of EGPWLEEEEE (SEQ ID NO: 1) claim 1 , EGPWLEEEE (SEQ ID NO: 2) claim 1 , EGPWLEEEEEAY (SEQ ID NO: 3) claim 1 , and EGPWLEEEEEAYGWMDF (SEQ ID NO: 4).3. The method of claim 2 , wherein the gastrin peptide is conjugated to an immunogenic carrier claim 2 , optionally via a linker.4. The method of claim 3 , wherein the immunogenic carrier is selected from the group consisting of diphtheria toxoid claim 3 , tetanus toxoid claim 3 , keyhole limpet hemocyanin claim 3 , and bovine serum albumin.5. ...

CONTEXT-AWARE EVENT BASED ANNOTATION SYSTEM FOR MEDIA ASSET

Various embodiments described herein support or provide for annotation of a media asset, such as an audio asset or a video asset, based on one or more events identified within content of the media asset. In particular, some embodiments can determine one or more of the following details with respect to content of a given media asset, which can represent annotations that enable determination of contextual information for the given media asset: events; event classification labels for events; subclassifications labels for events; scenes comprising events; attributes of scenes; themes presented by the content; and title-level attributes of the given media asset. 1. A method comprising:accessing, by a hardware processor, content data for a current media asset;determining, by the hardware processor, a set of events within the content data by scanning the content data for events that relate to at least one event classification, each event in the set of events comprising at least one of a visual content element, a textual content feature, or an audio content feature from the content data being presented at a timestamp of the current media asset, each event in the set of events being associated with an event classification label selected from a predetermined event classification library, the predetermined event classification library comprising a plurality of event classification labels where each event classification label comprises a set of available event subclassification labels;for each individual event in the set of events and based on an identified event classification label of the individual event, determining a set of identified event subclassification labels for the individual event, the set of identified event subclassification labels being selected from the set of available subclassification labels for the identified event classification as provided by the predetermined event classification library;determining, by the hardware processor, a set of scenes within the ...

Pyrrole derivatives as ligands of melanocortin receptors

Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders. The compounds having the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein A, n, R1, R2, R3a, R3b, R4, R5, R6 and R7 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

CONTENT GENOME GENERATION AND MANAGEMENT SYSTEM IN A MULTI-MODAL ARTIFICIAL INTELLIGENCE SYSTEM FOR MEDIA ASSETS

Various embodiments described herein support or provide for content genome generation and management operations of a media asset, such as accessing content data of a media asset and a set of input cues associated with the media asset; identifying a set of elements based on the content data of the media asset and the set of input cues; assigning a set of weight values to the set of elements based on a priority rule; identifying one or more relevant elements from the set of elements based on a ranking of the set of weight values; analyzing the one or more relevant elements to generate a set of classified features based on a set of tags; and using a machine learning algorithm to generate a content genome of the media asset based on the set of classified features.

(2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof

The present invention relates to (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems.

(2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof

(2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof

The present invention relates to (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems.

Low sheen deep base coating composition

The present invention relates to a composition comprising an aqueous dispersion of a) polymer particles having a z-average particle size in the range of from 80 nm to 500 nm; b) polymeric crosslinked organic microspheres having a D50 particle size in the range of from 1 m to 30 m; c); a colorant and d) a zinc or zirconium compound. The composition of the present invention is useful for reducing leaching from a coating prepared from a deep base, low sheen paint formulation.

(2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof

The present invention relates to (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms thereof, methods for its preparation, novel intermediates, and methods for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central and autonomic nervous systems.

(2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2- carboxamide, novel salt forms, and methods of use thereof

(2S,3R)-N-(2-((3-piridinil)metil-1-azabiciklo[2,2,2]okt-3-il)benzofuran-2-karboksamid hidrohlorid ili njegov hidrat ili solvat.Prijava sadrži još 12 patentnih zahteva. (2S, 3R) -N- (2 - ((3-pyridinyl) methyl-1-azabicyclo [2,2,2] oct-3-yl) benzofuran-2-carboxamide hydrochloride or a hydrate or solvate thereof. 12 patent claims.

Method and apparatus for stand alone appraisals and estimations

A stand alone computer system (10), supported by a high density storage medium (14) provides a user friendly on-site estimating system. The system is adaptable to insurance and body shop environs. It includes communications capabilities to supplement the data available in the stand alone configuration. The configuration provides an easy to use estimate data entry scheme which provides the user with running updates about parts and labor as the estimate is being created.

3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof

The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the a7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.

Composition

composição. a presente invenção é uma composição que compreende uma mescla de um látex à base de pva e um látex poliacrílico à base de ea/mma. a composição da presente invenção é útil em uma formulação de tinta para fornecer um revestimento com resistência ao atrito superior em relação a uma formulação que compreende uma mescla de látex à base de pva e látex poliacrílico à base de ba/mma. composition. the present invention is a composition comprising a blend of a pva-based latex and an ea/mma-based polyacrylic latex. The composition of the present invention is useful in a paint formulation to provide a coating with superior abrasion resistance over a formulation comprising a blend of pva-based latex and ba/mma-based polyacrylic latex.

(2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof

Method for tuning gloss or color in paint formulations

The present invention relates to a method for preparing a multiplicity of containers of paint from a plurality of vessels separately containing an aqueous solution of a rheology modifier, an aqueous dispersion of a colorant, an aqueous dispersion of polymer particles, and an aqueous dispersion of organic polymeric microspheres. In another embodiment, the present invention relates to a method of dispensing a colorant or an opacifying agent or an inorganic extender into separate containers partially filled with a waterborne pre-paint mixture of rheology modifier, polymer particles, and organic polymeric microspheres. The process of the present invention provides a simple and cost-effective way of preparing a wide variety of a large quantity of contained and finished paints at point-of-sale.

(2S, 3R) -N- (2 - ((3-pyridinyl) methyl) -1-azabicyclo [2.2.2] oct-3-yl) benzofuran-2-carboxamide, novel salt forms, and methods for their use

(2s,3r)-n-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2-carboxamide, novel salt forms, and methods of use thereof

Disclosed is (2S,3R) N-(2-((3-pyridinyl)methyl-1-azabicyclo[2.2.2]oct-3-yl)benzofuran-2- carboxamide, substantially free of (2S,3S), (2R,3S), or (2R,3R) isomers, or a pharmaceutically acceptable salt thereof for use in the treatment of mild cognitive impairment, age-associated memory impairment, pre-senile dementia, early onset Alzheimer's disease, senile dementia, dementia of the Alzheimer's type, Alzheimer's disease, Lewy Body dementia, micro- infarct dementia, AIDS-related dementia, HIV -dementia, multiple cerebral infarcts, Parkinsonism, Parkinson's disease, Pick's disease, progressive supranuclear palsy, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, attention deficit disorder, attention deficit hyperactivity disorder, anxiety, depression, dyslexia, schizophrenia, cognitive dysfunction in schizophrenia, depression, obsessive-compulsive disorders, or Tourette's syndrome.

(2S, 3R) -N- (2 - ((3-pyridinyl) methyl) -1-azabicyclo [2.2.2] oct-3-yl) benzofuran-2-carboxamide, new salt forms, and methods of use of the same

Un clorhidrato de (2S,3R)-N-(24U3-piridinifimetil)-1-azabiciclo[2.2.2]oct-3-il) bezofruran-2-carboxamida o un hidratoo solvato del mismo. A (2S, 3R) -N- (24U3-pyridinifimethyl) -1-azabicyclo [2.2.2] oct-3-yl) bezofruran-2-carboxamide hydrochloride or a solvate hydrate thereof.

Azabicycyclic compounds for relieving pain and treating central nervous system disorders

Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a compound of Formulas (1 or 2), as described herein. The compounds of Formulas (1 and 2) are also useful for treating pain, and treating drug addiction, nicotine addiction, and/or obesity. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.

Ligands of melanocortin receptors and compositions and methods related thereto

Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders, and may be used to treat disorders or illnesses including eiating disorders, cachexia, obesity, diabetes, metabolic disorders, inflammation, pain, skin disorders; skin and hair coloration, male and female sexual dysfuntion, erectile dysfunction, dry eye acne and/or Cushing's disease. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein A, m, n R1, R2, R3a, R3b, R4, R5, R6, W1, W2, W3, W4, Y1, Y2, Y3 and Y4 area defined herin. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

Method for tuning gloss or color in paint formulations

The present invention relates to a method for preparing a multiplicity of containers of paint from a plurality of vessels separately containing an aqueous solution of a rheology modifier, an aqueous dispersion of a colorant, an aqueous dispersion of polymer particles, and an aqueous dispersion of organic polymeric microspheres. In another embodiment, the present invention relates to a method of dispensing a colorant or an opacifying agent or an inorganic extender into separate containers partially filled with a waterborne pre-paint mixture of rheology modifier, polymer particles, and organic polymeric microspheres. The process of the present invention provides a simple and cost-effective way of preparing a wide variety of a large quantity of contained and finished paints at point-of-sale.

3-Substituted 2 (Arylalkyl) -1-Azabicycloalkanes and Their Use

Foreliggende oppfinnelse omhandler 3-substituerte-2-(arylalkyl)-1-azabicykloalkaner, fremgangsmåter for fremstilling av forbindelsene og fremgangsmåter for behandling ved anvendelse av forbindelsene. Azabicykloalkanene er generelt azabicykloheptaner, azabicyklooktaner eller azabicyklononaner. Arylgruppen i arylalkylgruppen er en 5- eller 6-leddet ring heteroaromat, fortrinnsvis 3-pyridinyl og 5-pyrimidinylgrupper og alkylgruppen er typisk en C1-4 alkyl. Substituenten i 3-stilling av 1-azabicykloalkanet er en karbonylgruppeholdig gruppe, så som et amid, karbamat, urinstoff, tioamid, tiokarbamat, tiourinstoff eller lignende funksjonalitet. Forbindelsene viser aktivitet ved nikotiniske acetylkolinreseptorer (nAChR-er), spesielt a7 nAChR undertypen og er anvendelige mot modulering av nevrotransmisjon og frigjøringen av ligander involvert i nevrotransmisjon. Fremgangsmåter for forhindring eller behandling av tilstander og lidelser, inkludert sentralnervesystem (CNS) lidelser, som er karakterisert ved en endring i normal nevrotransmisjon, er også beskrevet. Også beskrevet er fremgangsmåter for behandling av inflammasjon, autoimmune lidelser, smerte og overskudd av neovaskularisering, så som den forbundet med tumorvekst.

Media asset rating prediction for geographic region

Various embodiments described herein support or provide for predicting a rating for a media asset for one geographic region based on a reference rating of the media asset for another geographic region.

Cultural distance prediction system for media asset

Various embodiments described herein support or provide for cultural distance prediction operations of a media asset, such as determining events in a media asset, determining geographical region corresponding to the culture of origin and the culture of destination, accessing weight values of cultural attribute categories respectively associated with the geographical regions of the culture of origin and the culture of destination, generating cultural distance score of events, and causing display of the cultural distance score on a user interface of a client device.

Method for tuning gloss or color in paint formulations

The present invention relates to a method for preparing a multiplicity of containers of paint from a plurality of vessels separately containing an aqueous solution of a rheology modifier, an aqueous dispersion of a colorant, an aqueous dispersion of polymer particles, and an aqueous dispersion of organic polymeric microspheres. In another embodiment, the present invention relates to a method of dispensing a colorant or an opacifying agent or an inorganic extender into separate containers partially filled with a waterborne pre-paint mixture of rheology modifier, polymer particles, and organic polymeric microspheres. The process of the present invention provides a simple and cost-effective way of preparing a wide variety of a large quantity of contained and finished paints at point-of-sale.

Azabicyclische verbindungen zur linderung von schmerzen und zur behandlung von erkrankungen des zentralen nervensystems

Low sheen deep base coating composition

The present invention relates to a composition comprising an aqueous dispersion of a) polymer particles having a z-average particle size in the range of from 80 nm to 500 nm; b) polymeric crosslinked organic microspheres having a D50 particle size in the range of from 1 μm to 30 μm; c); a colorant and d) a zinc or zirconium compound. The composition of the present invention is useful for reducing leaching from a coating prepared from a deep base, low sheen paint formulation.

Context-aware event based annotation system for media asset

Various embodiments described herein support or provide for annotation of a media asset, such as an audio asset or a video asset, based on one or more events identified within content of the media asset. In particular, some embodiments can determine one or more of the following details with respect to content of a given media asset, which can represent annotations that enable determination of contextual information for the given media asset: events; event classification labels for events; subclassifications labels for events; scenes comprising events; attributes of scenes; themes presented by the content; and title-level attributes of the given media asset.

Context- aware event-based annotation system for media asset

Various embodiments described herein support or provide for annotation of a media asset, such as an audio asset or a video asset, based on one or more events identified within content of the media asset. In particular, some embodiments can determine one or more of the following details with respect to content of a given media asset, which can represent annotations that enable determination of contextual information for the given media asset: events; event classification labels for events; subclassifications labels for events; scenes comprising events; attributes of scenes; themes presented by the content; and title-level attributes of the given media asset.

Low sheen deep base coating composition

The present invention relates to a composition comprising an aqueous dispersion of a) polymer particles having a z-average particle size in the range of from 80 nm to 500 nm; b) polymeric crosslinked organic microspheres having a D50 particle size in the range of from 1 m to 30 m; c); a colorant and d) a zinc or zirconium compound. The composition of the present invention is useful for reducing leaching from a coating prepared from a deep base, low sheen paint formulation.

3-substitutierte-2(arylalkyl)-1-azabicycloalkan und methoden zu deren verwendung

Method for tuning gloss or color in paint formulations

The present invention relates to a method for preparing a multiplicity of containers of paint from a plurality of vessels separately containing an aqueous solution of a rheology modifier, an aqueous dispersion of a colorant, an aqueous dispersion of polymer particles, and an aqueous dispersion of organic polymeric microspheres. In another embodiment, the present invention relates to a method of dispensing a colorant or an opacifying agent or an inorganic extender into separate containers partially filled with a waterborne pre-paint mixture of rheology modifier, polymer particles, and organic polymeric microspheres. The process of the present invention provides a simple and cost-effective way of preparing a wide variety of a large quantity of contained and finished paints at point-of-sale.

Cultural distance prediction system for media asset

Various embodiments described herein support or provide for cultural distance prediction operations of a media asset, such as determining events in a media asset, determining geographical region corresponding to the culture of origin and the culture of destination, accessing weight values of cultural attribute categories respectively associated with the geographical regions of the culture of origin and the culture of destination, generating cultural distance score of events, and causing display of the cultural distance score on a user interface of a client device.

Media asset rating prediction for geographic region

Various embodiments described herein support or provide for predicting a rating for a media asset for one geographic region based on a reference rating of the media asset for another geographic region.

Media asset rating prediction for geographic region

Various embodiments described herein support or provide for predicting a rating for a media asset for one geographic region based on a reference rating of the media asset for another geographic region.

Media asset rating prediction for geographic region

Various embodiments described herein support or provide for predicting a rating for a media asset for one geographic region based on a reference rating of the media asset for another geographic region.

Media asset rating prediction for geographic region

Various embodiments described herein support or provide for predicting a rating for a media asset for one geographic region based on a reference rating of the media asset for another geographic region.

Cultural distance prediction system for media asset

Various embodiments described herein support or provide for cultural distance prediction operations of a media asset, such as determining events in a media asset, determining geographical region corresponding to the culture of origin and the culture of destination, accessing weight values of cultural attribute categories respectively associated with the geographical regions of the culture of origin and the culture of destination, generating cultural distance score of events, and causing display of the cultural distance score on a user interface of a client device.

User response collection interface generation and management using machine learning technologies

Various embodiments described herein support or provide generation and management operations of user response collection interfaces using machine learning technologies, including receiving a user input from a user interface of a device, the user input including data content that describes context of a media asset; using a machine learning model to generate analysis of the context of the media asset based on the data content; dynamically generating a question based on the analysis of the context of the media asset; and causing display of the question and the plurality of answers on the user interface of the device.

Context-aware event based annotation system for media asset

Various embodiments described herein support or provide for annotation of a media asset, such as an audio asset or a video asset, based on one or more events identified within content of the media asset. In particular, some embodiments can determine one or more of the following details with respect to content of a given media asset, which can represent annotations that enable determination of contextual information for the given media asset: events; event classification labels for events; subclassifications labels for events; scenes comprising events; attributes of scenes; themes presented by the content; and title-level attributes of the given media asset.

Compositions and methods for preventing tumors and cancer

Provided are methods for preventing initiation and/or progression of gastrin-associated tumors and/or cancers in subjects. In some embodiments, the methods relate to administering compositions that gastrin immunogens to subjects. Also provided are methods for inhibiting development of gastrin-associated precancerous lesions, methods for preventing formation of fibrosis associated with a tumor and/or a cancer, uses of compositions that include a gastrin immunogen to prevent initiation and/or development of a gastrin-associated tumor or cancer and/or for preparing medicaments therefor, and compositions for use in preventing initiation and/or development of gastrin-associated tumors and/or cancers and/or precancerous lesions thereof.

Context- aware event-based annotation system for media asset

Various embodiments described herein support or provide for annotation of a media asset, such as an audio asset or a video asset, based on one or more events identified within content of the media asset. In particular, some embodiments can determine one or more of the following details with respect to content of a given media asset, which can represent annotations that enable determination of contextual information for the given media asset: events; event classification labels for events; subclassifications labels for events; scenes comprising events; attributes of scenes; themes presented by the content; and title-level attributes of the given media asset.

Content genome generation and management system in a multi-modal artificial intelligence system for media assets

Various embodiments described herein support or provide for content genome generation and management operations of a media asset, such as accessing content data of a media asset and a set of input cues associated with the media asset; identifying a set of elements based on the content data of the media asset and the set of input cues; assigning a set of weight values to the set of elements based on a priority rule; identifying one or more relevant elements from the set of elements based on a ranking of the set of weight values; analyzing the one or more relevant elements to generate a set of classified features based on a set of tags; and using a machine learning algorithm to generate a content genome of the media asset based on the set of classified features.

Content genome generation and management system in a multi-modal artificial intelligence system for media assets

Various embodiments described herein support or provide for content genome generation and management operations of a media asset, such as accessing content data of a media asset and a set of input cues associated with the media asset; identifying a set of elements based on the content data of the media asset and the set of input cues; assigning a set of weight values to the set of elements based on a priority rule; identifying one or more relevant elements from the set of elements based on a ranking of the set of weight values; analyzing the one or more relevant elements to generate a set of classified features based on a set of tags; and using a machine learning algorithm to generate a content genome of the media asset based on the set of classified features.

Content genome generation and management system in a multi-modal artificial intelligence system for media assets

Various embodiments described herein support or provide for content genome generation and management operations of a media asset, such as accessing content data of a media asset and a set of input cues associated with the media asset; identifying a set of elements based on the content data of the media asset and the set of input cues; assigning a set of weight values to the set of elements based on a priority rule; identifying one or more relevant elements from the set of elements based on a ranking of the set of weight values; analyzing the one or more relevant elements to generate a set of classified features based on a set of tags; and using a machine learning algorithm to generate a content genome of the media asset based on the set of classified features.

Context- aware event-based annotation system for media asset

Various embodiments described herein support or provide for annotation of a media asset, such as an audio asset or a video asset, based on one or more events identified within content of the media asset. In particular, some embodiments can determine one or more of the following details with respect to content of a given media asset, which can represent annotations that enable determination of contextual information for the given media asset: events; event classification labels for events; subclassifications labels for events; scenes comprising events; attributes of scenes; themes presented by the content; and title-level attributes of the given media asset.

Cultural distance prediction system for media asset

Various embodiments described herein support or provide for cultural distance prediction operations of a media asset, such as determining events in a media asset, determining geographical region corresponding to the culture of origin and the culture of destination, accessing weight values of cultural attribute categories respectively associated with the geographical regions of the culture of origin and the culture of destination, generating cultural distance score of events, and causing display of the cultural distance score on a user interface of a client device.

Ligands of melanocortin receptors and compositions and methods related thereto

Cultural distance prediction system for media asset

Various embodiments described herein support or provide for cultural distance prediction operations of a media asset, such as determining events in a media asset, determining geographical region corresponding to the culture of origin and the culture of destination, accessing weight values of cultural attribute categories respectively associated with the geographical regions of the culture of origin and the culture of destination, generating cultural distance score of events, and causing display of the cultural distance score on a user interface of a client device.

Compositions and methods for preventing tumors and cancer

Provided are methods for preventing initiation and/or progression of gastrin-associated tumors and/or cancers in subjects. In some embodiments, the methods relate to administering compositions that gastrin immunogens to subjects. Also provided are methods for inhibiting development of gastrin-associated precancerous lesions, methods for preventing formation of fibrosis associated with a tumor and/or a cancer, uses of compositions that include a gastrin immunogen to prevent initiation and/or development of a gastrin-associated tumor or cancer and/or for preparing medicaments therefor, and compositions for use in preventing initiation and/or development of gastrin-associated tumors and/or cancers and/or precancerous lesions thereof.

Method for tuning gloss or color in paint formulations

The present invention relates to a method for preparing a multiplicity of containers of paint from a plurality of vessels separately containing an aqueous solution of a rheology modifier, an aqueous dispersion of a colorant, an aqueous dispersion of polymer particles, and an aqueous dispersion of organic polymeric microspheres. In another embodiment, the present invention relates to a method of dispensing a colorant or an opacifying agent or an inorganic extender into separate containers partially filled with a waterborne pre-paint mixture of rheology modifier, polymer particles, and organic polymeric microspheres. The process of the present invention provides a simple and cost-effective way of preparing a wide variety of a large quantity of contained and finished paints at point-of-sale.

Blend of polyacrylic and polyvinyl acetate latexes

The present invention is a composition comprising a blend of a PVA based latex and an EA/MMA based polyacrylic latex. The composition of the present invention is useful in a paint formulation for providing a coating with superior scrub resistance over a formulation comprising a blend of a PVA based latex and a BA/MMA based polyacrylic latex.

Context-aware event based annotation system for media asset

Various embodiments described herein support or provide for annotation of a media asset, such as an audio asset or a video asset, based on one or more events identified within content of the media asset. In particular, some embodiments can determine one or more of the following details with respect to content of a given media asset, which can represent annotations that enable determination of contextual information for the given media asset: events; event classification labels for events; subclassifications labels for events; scenes comprising events; attributes of scenes; themes presented by the content; and title-level attributes of the given media asset.