22-08-2013 дата публикации
Номер: US20130216435A1
The present invention relates to an optical imaging system communicatively connected to a microwave energy producing source wherein the combination provides for increases in chemical reaction times and the ability to monitor the reactions in real time with sufficient resolution to view the location of intracellular components labeled with luminescent molecules as well as interaction with other biomolecules and responses to localized environmental variables in living cells and tissues during the application of a microwave field. 1. A microwave/optical imaging system comprising:a) an enclosed container comprising a microwave cavity and having at least one opening therein;b) a sample plate positioned within the microwave cavity for holding at least one sample, wherein the sample plate comprises at least one layer of metallic material deposited on the sample plate surface, wherein the metallic material is formed into a patterned shape, wherein the patterned shape is selected from the group consisting of a triangle, square, rectangle, trapezoid, polygon, parabola, elliptical, sector of a circle and a combinations thereof, wherein the sample comprises a detector molecule or components of a detectable reaction;c) a microwave energy producing source communicatively connected to the microwave cavity for delivering microwave energy into the cavity and directed towards the sample; andd) an optical imaging device communicatively connected to the microwave cavity and positioned for directing excitation light from an electromagnetic energy producing source to the sample and capturing luminescent emissions emitted from the sample.2. The system of claim 1 , wherein the microwave cavity includes a stage for holding the sample plate.3. The system of claim 1 , wherein the detector molecule is a fluorophore.4. The system of claim 1 , wherein the delivered microwave energy has a frequency of from 2 GZ to 3 GZ claim 1 , and a power level in a range between about 10 mwatts and 700 watts.5 ...
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