Transdermal porator and patch system and method for using same

A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.

Standard-compliant label and method of providing a standard compliant label

Provided is a label generated on-demand for identifying a medicinal substance to be administered to a patient. The label includes a content surface on which label content is printed on-demand by a computer printer. The label content includes information required by a medical labeling standard. An adhesive surface is provided to be applied against a container for storing the medicinal substance and adhering the label to the container. A color code is visible when viewing the content surface. The color code is specified by the medical labeling standard for conveying information about the medicinal substance to be stored in the container, and the label content and color code render the label compliant with the medical labeling standard.

Event classification method using lit candle detection

A method for determining an event classification for digital images, comprising: receiving one or more digital images; detecting one or more lit candles within the one or more digital images; using a data processor to automatically determine an event classification responsive to analyzing a spatial arrangement of the detected lit candles in the one or more digital images; and storing metadata in a processor-accessible memory associating the determined event classification with each of the one or more digital images.

Event classification method for related digital images

A method for determining an event classification for a set of related digital images, comprising: receiving a set of related digital images; detecting one or more man-made light emitting sources within at least one of the digital images; using a data processor to automatically determine an event classification responsive to analyzing a spatial arrangement of the detected man-made light emitting sources in the one or more digital images; and storing metadata in a processor-accessible memory associating the determined event classification with each of the digital images in the set of digital images.

System for extracting text from a document

A system including a data processing system, a network interface for communicating over a network, and a program memory storing instructions configured to cause the data processing system to implement a method for extracting textual information from images of a document containing text characters. The method includes receiving a plurality of digital images of the document over the network. Each of the captured digital images is automatically analyzed using an optical character recognition process to determine extracted textual data. The extracted textual data for the captured digital images are merged to determine the textual information for the document, wherein differences between the extracted textual data for the captured digital images are analyzed to determine the textual information for the document.

Dispensing bottle

A bottle for dispensing adhesives includes a bottom portion with greater cross-section than that of a mid portion of the bottle to provide stability to the bottle. The bottom portion accommodates greater amount of adhesive therein than the mid portion of the bottle. The bottle includes a top portion having a textured top portion outer surface for improved gripping surface.

Connector for multiple sized connections

A connector is used to connect a gases supply to a user. The user can be fitted with an interface, such as a cannula, while the gases supply can include a conduit. The connector interfaces between the conduit and the interface. The connector has a female assembly and a male assembly that connect together, such as by push fit. The male assembly includes an inner portion sized and configured to mate with a first female connector and an outer portion sized and configured to alternatively mate with a second female connector.

Breathing assistance apparatus with serviceability features

A breathing assistance apparatus is configured with features that improve serviceability of the apparatus. The apparatus can include animations to provide instruction regarding correcting easily-identified fault conditions and to provide instruction regarding routine maintenance routines. The apparatus also can be configured with top level control menus that are obscured in a manner to limit manipulation of the top level control elements by unauthorized users.

Apparatus for measuring properties of gases supplied to a patient

The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.

Modifying a graphic design to match the style of an input design

The present disclosure is directed toward systems and methods for retargeting a user's input digital design based on a selected template digital design. For example, in response to the user's selection of a template digital design, one or more embodiments described herein change various design features of the user's input digital design to match corresponding design features in the selected template digital design. One or more embodiments described herein also provide template digital designs to the user for use in retargeting after a two-step selection process that ensures the provided template digital designs are compatible with the user's input digital design.

Respiratory assistance apparatus

A respiratory assistance apparatus has a gases inlet configured to receive a supply of gases, a blower unit configured to generate a pressurised gases stream from the supply of gases; a humidification unit configured to heat and humidify the pressurised gases stream; and a gases outlet for the heated and humidified gases stream. A flow path for the gases stream extends through the respiratory device from the gases inlet through the blower unit and humidification unit to the gases outlet. A sensor assembly is provided in the flow path before the humidification unit. The sensor assembly has an ultrasound gas composition sensor system for sensing one or more gas concentrations within the gases stream.

Patient interface and headgear for a respiratory apparatus

Patient interface, such as a nasal cannula, with a headgear. The interface has a soft face mount part with nasal prongs and a base portion, and a harder-material gases flow manifold part with an inlet and an outlet. Gas is delivered into the manifold inlet, and flows out through the outlet and into the base portion of the face mount. The outlet of the manifold part comprises a groove that creates a gap between the base portion of the face mount and the manifold part at a region adjacent to the philtrum, providing pressure relief on the septum. The headgear has straps. Portions of the headgear that contact facial regions have surface regions for frictionally engaging with the skin. The material in these regions can be in the form of sleeves or coatings or over-moulding. The remainder of the strap has different material properties from those contacting the facial region.

Breathing assistance apparatus with serviceability features

A breathing assistance apparatus is configured with features that improve serviceability of the apparatus. The apparatus can include animations to provide instruction regarding correcting easily-identified fault conditions and to provide instruction regarding routine maintenance routines. The apparatus also can be configured with top level control menus that are obscured in a manner to limit manipulation of the top level control elements by unauthorized users.

Breathing assistance apparatus

A nasal cannula assembly is disclosed having a face mount part, in use resting against a user's face, which includes at least one nasal prong capable of being fitted into a person's nares. The cannula assembly also includes a manifold part, in fluid communication with the face mount part, having a single horizontal side gases entry. In particular, this cannula assembly is for supplying heated, humidified gases to a patient suffering from COPD. A tie or lanyard is disclosed for use with a breathing assistance apparatus such as a nasal cannula, face or nasal mask or tracheostomy connector. The tie or lanyard transfers the weight of the conduits supplying gases to the breathing assistance apparatus from the breathing assistance apparatus and distributes it onto the neck of the patient.

Determining causal models for controlling environments

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining causal models for controlling environments. One of the methods includes identifying a procedural instance; determining a temporal extent for the procedural instance based on temporal extent parameters for the one or more entities in the procedural instance; selecting control settings for the procedural instance; monitoring environment responses to the control settings that are received for the one or more entities; determining which of the environment responses to attribute to the procedural instance in a causal model; and adjusting, based at least in part on the environment responses that are attributed to the procedural instance, the temporal extent parameters for the one or more entities.

High precision reciprocating bob viscometer

A high precision, reciprocating bob viscometer is shown that has two coils (A and B) encircling a reciprocating bob. Coil A is energized with a combined sinusoidal and DC signal, while coil B senses the position of the reciprocating bob, then the functions of coils A and B are reversed. By use of a large digitally-generated near resonance frequency sinusoidal signal, noise is reduced because there is no need for amplification. The sensed signal amplitude measurement is in the digital time domain instead of through analog amplitude measurements, which further eliminates signal noise. These advancements provide faster, highly accurate, low noise measurements of bob position and velocity to determine fluid/gas viscosity and related properties using a reciprocating bob viscometer. These related properties include measurements of density, shear sensitivity, yield stress, and other measurements described in prior art patents.

Method and system for non-destructive rail inspection

The present invention relates to a method for identifying and locating a defect in a metal rail, and includes the steps of positioning a first magnetic sensor at a distance above a rail, the first magnetic sensor being configured to measure a magnetic field of the rail; advancing the sensor along a length of the rail; sampling magnetic field measurements; determining multiple magnetic field gradients over different pluralities of samples; identifying a defect in the rail based on a change in one or more of the magnetic field gradients; and determining a position of the defect at a particular distance from the magnetic sensor based on a degree of variation in the magnetic field gradients.

Flexible wristwatch with segmented e-paper display

A thin and flexible wrist watch that includes a segmented e-paper display screen for displaying time. The watch is programmable and rechargeable by interaction with a base station.

Breathing assistance apparatus

An apparatus for delivering a flow of gas, has a housing 3202 ′ with a recess, and an outlet port 3210 ′ for a flow of gas. The recess is defined by at least one wall 3256, 3262 that is substantially continuous, gas impermeable, and unbroken, other than a gasflow passage from the recess to the outlet port of the housing.

Method and apparatus for providing information in response to the grant of a subscriber's permission

Confirmation of a mobile subscriber's permission to release their personal information is completed prior to transmitting the information to a requesting party. The mobile subscriber can view the requesting party's identity prior to making a decision to release their directory information. In the alternative, the mobile subscriber can contact the requesting party directly without a release of their personal information. Other types of information, such as location information, can also be communicated to a requesting party by this permission grant methodology.

Breathing assistance apparatus with a manifold to add auxiliary gases to ambient gases

The breathing assistance apparatus of the present invention includes a manifold that is provided with or retrofittable to gases supply and humidifying devices. The manifold allows gases from an oxygen concentrator to be combined with the flow through a gases supply and humidifying device, most usually air The combined output of oxygen and other breathing gases (air) is then humidified. The breathing assistance apparatus and manifold of the present invention provides a safe method to add oxygen to the input air stream of a gases supply and humidifying device and reduces the amount of accumulation of oxygen within the gases supply device, reducing fire risk should sparking occur within the device.

Multilayer adhesive article

An adhesive article is described comprising a foamed adhesive layer and a non-foamed adhesive layer. The adhesive of each adhesive layer comprises a tetrahydrofurfuryl (meth)acrylate copolymer; an epoxy resin; a polyether polyol; and optionally a hydroxy-functional film-forming polymer. The adhesive may be used in structural and semi-structural bonding applications and is designed to fail cohesively.

Apparatus for measuring properties of gases supplied to a patient

The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermister 23 ), of gases flowing through a heated tube ( 3 ), supplying gases to a patient, which utilises the heating wire ( 21, 28 ) within the tube.

Systems and methods for hypoxic gas delivery for altitude training and athletic conditioning

A flow therapy apparatus can provide a hypoxic flow of gases to a user, for altitude training, athletic performance training, and other indications. The system can include an apparatus that can include a gas conduit, an ambient air inlet, and a hypoxic gas source inlet configured to connect to a hypoxic gas source and configured to create a hypoxic gas composition upon mixing of ambient air and the hypoxic gas. The system can also include a user interface, and a gas flow generation element configured to deliver the hypoxic gas composition to nares of the user at a predetermined flow rate of at least about 10 liters/minute. Methods are also disclosed.

Instruments and methods for manipulating vertebra

A method for manipulating a vertebra includes connecting a first bone anchor to a first vertebra, connecting a second bone anchor to a second bone anchor, positioning a spinal rod in a receiving member of the first bone anchor and in a receiving member of the second bone anchor, connecting a first instrument to the receiving member of the first bone anchor, and manipulating the first instrument to rotate first bone anchor and the first vertebra relative to the second vertebra.

Photonic subsystem

At least one embodiment of the invention provides a photonic subsystem for integrating onto a photonic platform. The subsystem comprises a laser source and a plurality of optical components for focusing and directing a laser beam emitted from the laser source into a photonic platform. The laser source and plurality of optical components are mounted to a substrate and encapsulated.

Nk cells for use with anitbodies in cancer therapy

Herceptin.

Apparatus for measuring properties of gases supplied to a patient

The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermister), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.

Dosage dispensing devices

A dosage dispensing device is described having means for recording the number of times the device is used. Such means are provided by an electronic counting assembly.

Pressurizing masks, systems and methods

Dosage dispensing devices

On décrit un dispositif doseur muni de moyens permettant d'enregistrer le nombre de fois que ledit dispositif a été utilisé. Les moyens prévus à cet effet sont représentés par un ensemble de comptage électronique. A metering device is described provided with means making it possible to record the number of times that said device has been used. The means provided for this purpose are represented by an electronic counting assembly.

Test module

A test module or reagent handling device for use with a clinical analyzer for conducting body serum assays and/or immunoassays; the test module coacting with the analyzer to selectively provide a plurality of liquid dilution and reagent materials to a serum sample, the test module having programmable valve means coacting with a dispense probe to serially: select a serum sample and to deposit said sample and liquid dilution material into a dilution cup or vessel; subsequentially withdraw a portion of the diluted serum from the dilution cup and to dispense said diluted serum portion along with at least one liquid reagent material into a reaction cup or vessel.

Pulsed flow equipment insertion method and apparatus for carrying out the method

There is disclosed a method for deploying container inspection equipment from a conduit into a fluid container, comprising: filling the conduit containing the equipment with a first fluid at a first pressure; releasing a second fluid at a second pressure greater than the first pressure, wherein the release of the second fluid generates a sufficient force to move the fluid in the conduit past the equipment and in a direction towards the container, and wherein the moving fluid pushes the equipment in the conduit at least a distance and in the direction towards the container. There is disclosed a apparatus for deploying equipment from a conduit into a fluid container, the conduit in fluid communication with the container, comprising: a housing having a first portion and a second portion, the second portion in fluid communication with the interior of the conduit, the first portion including an aperture by which a second fluid at a second pressure, which is greater than the first pressure, can pass into the interior of the housing; wherein at rest, the equipment is received in the conduit and the conduit contains the first fluid, and wherein when it is desired to deploy the equipment into the container, a volume of the second fluid is released through the aperture and in a direction towards the container, and wherein the force generated by the movement of fluid past the equipment pushes the equipment in the conduit at least a distance and in the direction towards the container.

Method and system for mobile controlled handoff and link maintenance in spread spectrum communication

A simple and flexible over-air protocol for use with a mobile telephone system, having hand-held telephones in a microcell or other type of cellular communication system. A method in which user stations communicate with one or more base stations to place and receive telephone calls, in which the user stations are provided a secure voice or data link and have the ability to handoff calls between base stations while such calls are in progress. Each base station has a set of "air channels" to which it transmits in sequence. The air channels supported by each base station are called that base station's "polling loop". A user station receives general polling information on an unoccupied air channel, transmits responsive information to the base station, and awaits acknowledgment from the base station. Each base station may therefore simultaneously maintain communication with as many user stations as there are air channels in its polling loop. The ability of a user station to communicate on any unoccupied air channel makes the protocol air-channel agile, while the stability of user station and base station clocks may define air channels, gaps, and minor frames.

Cellular docking station

A system for communicating with the user of a cellular telephone via the cellular mobile radio (CMR) system and the public switched telephone network (PSTN). A communications interface appends the telephone exchange number of an outgoing communication to include an identifier unique to the communications interface. The outgoing communication is transmitted by the cellular telephone to the CMR system, which recognizes and verifies the outgoing communication as originating with the communications interface. Accordingly, the origination of the outgoing communication from a communications interface is documented prior to forwarding the outgoing communication to its intended recipient via the PSTN. Communications incoming to a communications interface are authenticated as such, and a record as to this is created, prior to forwarding the incoming communication to the cellular telephone.

Constrained motion bone screw assembly

A bone screw assembly includes an anchor portion and a head portion, such as a rod-receiving portion, movably mounted to the anchor portion to allow for controlled angulation between the anchor portion and the head portion. The anchor portion is pivotable in one or more selected directions about an axis relative to the head portion. A restriction member, which may be a rod seat, prevents the anchor portion from pivoting in one or more different directions about another axis relative to the head portion and/or a spinal fixation element received in the head portion. The restriction member may be inserted in the head portion to control direction that the anchor portion pivots relative to the head portion. The restriction member may also serve as a compression member and/or rod seat for seating a spinal rod coupled to the bone screw assembly.

Constrained motion bone screw assembly

A bone screw assembly includes an anchor portion and a head portion, such as a rod-receiving portion, movably mounted to the anchor portion to allow for controlled angulation between the anchor portion and the head portion. The anchor portion is pivotable in one or more selected directions about an axis relative to the head portion. A restriction member, which may be a rod seat, prevents the anchor portion from pivoting in one or more different directions about another axis relative to the head portion and/or a spinal fixation element received in the head portion. The restriction member may be inserted in the head portion to control direction that the anchor portion pivots relative to the head portion. The restriction member may also serve as a compression member and/or rod seat for seating a spinal rod coupled to the bone screw assembly.

Instruments and methods for manipulating vertebra

A method for manipulating a vertebra includes connecting a first bone anchor to a first vertebra, connecting a second bone anchor to a second bone anchor, positioning a spinal rod in a receiving member of the first bone anchor and in a receiving member of the second bone anchor, connecting a first instrument to the receiving member of the first bone anchor, and manipulating the first instrument to rotate first bone anchor and the first vertebra relative to the second vertebra.

Instruments and methods for manipulating vertebra

A method for manipulating a vertebra includes connecting a first bone anchor to a first vertebra, connecting a second bone anchor to a second bone anchor, positioning a spinal rod in a receiving member of the first bone anchor and in a receiving member of the second bone anchor, connecting a first instrument to the receiving member of the first bone anchor, and manipulating the first instrument to rotate first bone anchor and the first vertebra relative to the second vertebra.

Constrained motion bone screw assembly

A bone screw assembly includes an anchor portion and a head portion, such as a rod-receiving portion, movably mounted to the anchor portion to allow for controlled angulation between the anchor portion and the head portion. The anchor portion is pivotable in one or more selected directions about an axis relative to the head portion. A restriction member, which may be a rod seat, prevents the anchor portion from pivoting in one or more different directions about another axis relative to the head portion and/or a spinal fixation element received in the head portion. The restriction member may be inserted in the head portion to control direction that the anchor portion pivots relative to the head portion. The restriction member may also serve as a compression member and/or rod seat for seating a spinal rod coupled to the bone screw assembly.

Constrained motion bone screw assembly

A bone screw assembly includes an anchor portion and a head portion, such as a rod-receiving portion, movably mounted to the anchor portion to allow for controlled angulation between the anchor portion and the head portion. The anchor portion is pivotable in one or more selected directions about an axis relative to the head portion. A restriction member, which may be a rod seat, prevents the anchor portion from pivoting in one or more different directions about another axis relative to the head portion and/or a spinal fixation element received in the head portion. The restriction member may be inserted in the head portion to control direction that the anchor portion pivots relative to the head portion. The restriction member may also serve as a compression member and/or rod seat for seating a spinal rod coupled to the bone screw assembly.

Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them

The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.

Semiconductor conductive layers

Structures and methods for electronic devices with improved conductive regions are provided. The conductive region may include digital alloy superlattice structures, which allow higher doping levels to be achieved than for a bulk (random) alloy with the same average composition. Furthermore, the superlattice structures may improve the resistivity of the region, improving the current spreading of the region and hence the electronic properties of electronic devices such as optoelectronic devices.

Neurofibromatosis type 1 gene

The present invention relates to the neurofibromatosis type 1 (NF1) gene and its gene product. The invention further relates to methods for the detection in and treatment of humans having defective NF1 genes and for detection of tumors caused by a defective NF1 gene.

Wireless digital network

A wireless Integrated Services Digital Network ("WISDN") is disclosed. The WISDN replaces conventional wireless networks with a plurality of network elements including intelligent cellsites ("ICSs"), a central site controller ("CSC"), a billing aggregator and an operation and support system, all of which are interconnected to the public switched telephone network ("PSTN") via the integrated services digital network ("ISDN"). The ICSs communicate with users who request services via radio communication. The ICS in which a service requesting user is located interfaces the user with the ISDN, which terminates the user's call using traditional telephony switching methods. When a call to the user is initiated from a PSTN subscriber, the PSTN's service control point may access the CSC, which provides authentication services and routing information (such as the current location of the user) with which the PSTN terminates the call to the selected ICS. Registration techniques provide updates on the user's location. When the user moves out of the coverage area of the selected ICS, it initiates a hand off by sending messages, over the ISDN signalling channel, to surrounding ICSs requesting that each take a reading on the signal from the user. Reports are received from the surrounding ICSs and the selected ICS chooses a second ICS to which the call will be handed off.

Respiratory therapy system and apparatus

Described is a respiratory therapy system that comprises a respiratory therapy apparatus that is configured to provide a flow of breathable gas at, at least a first pressure and a second pressure to a patient. The respiratory therapy apparatus comprises a flow generator configured to provide the flow of breathable gas, a controller, coupled to a trigger sensor, to control respiratory therapy apparatus operations, a breathing conduit assembly that conveys the breathable gas to a patient via a patient interface, a trigger that produces a signal detectable by the trigger sensor. The controller is configured to control the flow generator to provide the flow of breathable gas at, at least the first pressure or the second pressure based on detection of the signal from the trigger.

Compositions comprising a fragment of the herpesviral protein vp22 for delivery of substances to cells

This invention relates to aggregated compositions comprising short peptides, or sub-sequences, of full length VP22 protein for delivery of substances such as nucleic acids and proteins into cells. The invention relates to such compositions in themselves, and to methods for their manufacture and use.

Pipeline monitoring array

An array of acoustic sensors spaced along a cable is deployed in a fluid filled concrete pipeline and the sensors are monitored to find acoustic anomalies, particularly anomalies resulting from breakage of a reinforcing wire for the concrete. The location of wire breaks is found from the data collected.

Apparatus for supplying gases to a patient

An apparatus for the supply of humidified gases to a patient is disclosed that comprises a gases supply passage downstream of a humidified gases supply, and upstream of a patient in use, where at least one sensor is embedded in or located on the outside of the wall of the passage. In preferred forms the wall of the passage divides the sensor(s) from a flow of gases in the passage. In use, a controller receives an output of the sensor(s) and derives from the output of the sensor(s) an estimation of a property of gases flowing through the passage or provides a control output to the humidified gases supply according to the output of the sensor(s).

Transdermal porator and patch system and method for using same

A transdermal permeant delivery system for delivery of at least one perme ant composition into a tissue membrane of a subject including a disposable s ubstrate having at least a portion of a bottom surface of a first release li ner connected to an upper surface of the substrate and a patch having a back ing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the f irst release liner in spaced registration with a poration area of the substr ate.

Method for protein n-myristoylation

07-24(661)A METHOD FOR PROTEIN N-MYRISTOYLATION Abstract of the Disclosure There is disclosed a method for providing for the coexpression of N-myristoyltransferase and a protein substrate for said N-myristoyltransferase in E. coli comprising introducing into E. coli a dual plasmid system comprising (A) the isopropyl-.beta.-D-thiogalactopyranoside-inducible tac promoter, the g10-L ribosome binding site, a NMT gene, the kanamycin resistance gene and the p15A origin of replication in operable sequence and (B) the recA promoter, the g10-L ribosome binding site, a mammalian gene, the ampicillin resistance gene and the Col El origin of replication in operable sequence. This allows production of mammalian N-myristoylproteins or proteins containing covalently linked analogs of myristate with altered physical-chemical properties.

Apparatus for measuring properties of gases supplied to a patient

The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermister 23), of gases flowing through a heated tube (3), supplying gases to a patient, which utilises the heating wire (21, 28) within the tube.

Transdermal porator and patch system and method for using same

A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.

Untethered, unpowered, rollable device to sense condition of pipeline wall

A sensor unit for use in sensing conditions in a pipeline comprises an untethered a ball-shaped surround adapted to roll along the interior surface of a pipeline, and instrument package within the ball-shaped surround. The package contains at least one magnetometer or accelerometer. Preferably, three magnetometers, arranged orthogonally, are present. Other sensors can also be present as required, such as an acoustic sensor to detect leaks and a temperature or chemical sensor. Recording means record the data acquired by the magnetometer(s) or accelerometer and the sensors, and optionally also record a timing trace.

Engineered natural killer cells and uses thereof

Provided herein are engineered natural killer cells that have been modified to express chimeric antigen receptors (CARs). The cells optionally contain other modifications that improve tumor specific cytotoxicity and homing to tumor sites. Also contemplated are methods for using the engineered natural killer cells to treat patients with cancer.

Frangible targets

PACKAGING FOR ANAEROBIC PRODUCTS

a presente invenção refere-se a uma embalagem compreendendo: um recipiente, o recipiente tendo um corpo recipiente, e o corpo recipiente sendo suficientemente permeável a oxigênio para prevenir que uma composição anaerobicamente curável mantida no mesmo seja curada devido à ausência de oxigênio; e uma composição anaerobicamente curável mantida dentro do recipiente. o corpo recipiente é construído de um material plástico que é formado de uma mistura de um componente de amido termoplástico e um polietileno. The present invention relates to a package comprising: a container, the container having a container body, and the container body being sufficiently permeable to oxygen to prevent an anaerobically curable composition held therein from being cured due to the absence of oxygen; and an anaerobically curable composition held within the container. the container body is constructed of a plastic material which is formed from a mixture of a thermoplastic starch component and a polyethylene.

A pack for anaerobic products

A pack comprising: a container, the container having a container body, and the container body being sufficiently oxygen permeable to prevent an anaerobically curable composition held therein from curing due to absence of oxygen; and an anaerobically curable composition held within the container. The container body is constructed from a plastics material which is formed from a blend of a thermoplastic starch component and a polyethylene.

Mining machine position tracking and mapping

A system for determining a position of a mining machine in an underground mine, the system including an emitter unit and a receiver unit, one of the units being positioned in fixed relation to a mine wall and the other unit being mounted relative to the machine, wherein the emitter unit transmits a coded magnetic signal that is received by the receiver unit, the system further including a processor to identify the distance and relative angle between the units based on the received signal. The system utilizes ranging of a through- strata coded low frequency magnetic field for real time and continuous 3-D positioning of the mining machine. The invention also relates to a method of tracking a mining machine and a mining operation.

Deriving power for an external device from a fluorescent light power source

Systems and methods are provided for deriving power for an external device from a circuit of a fluorescent light. A first circuit supplies power from a fluorescent light power source to a fluorescent lamp. The power converter of an external device can be electrically connected to any two points within that circuit to create a second circuit to supply power to the external device. The power converter may be connected to the first circuit via one or more power coupling or power tether. At least one of the two points within the first circuit may comprise a pin of the fluorescent lamp. Alternatively, at least one of the two points may comprise a connector of a fluorescent light fixture designed to receive a pin of the fluorescent lamp or a point within the fluorescent ballast of the fluorescent light fixture.

Constrained Motion Bone Screw Assembly

A hone screw assembly includes an anchor portion and a head portion, such as a rod-receiving portion, movably mounted to the anchor portion to allow for controlled angulation between the anchor portion and the head portion. The anchor portion is pivotable in one or more selected directions about an axis relative to the head portion. A restriction member, which may be a rod seat, prevents the anchor portion from pivoting in one or more different directions about another axis relative tr the head portion and/or a spinal fixation element received in the head portion. The restriction member may be inserted in the head portion to control direction that the anchor portion pivots relative, to the head portion. The restriction member may also serve as a compression member and/or rod seat for seating a spinal rod coupled to the bone screw assembly.

Device and method to assess impairment of pipeline wall strength

The invention locates impaired sections of a pipeline, such as sections where the wall of the pipeline has been weakened or thinned. It provides a moveable device which passes through the pipeline and which has a first station. The moveable device has means to locate its position accurately. There is a second station, which is mounted either on the moveable device or in association with a fixed location on the pipeline wall. Either the first station or the second station has an acoustic or seismic pulse generator, and the other has a pulse receiver. The time taken for a pulse to travel from the pulse generator to the receiver is found to vary with the condition of the pipeline wall at the location where the moveable device is located at the time it receives (or sends) the pulse. The rate of change of velocity of the pulse as the device passes different locations in the pipeline is also found to vary with the condition of the pipeline wall at such location.

Continuous monitoring of reinforcements in structures

Methods and system for inspecting train wheels and axles

The present invention relates to a method for identifying and locating a defect in a train wheel or an axle of a train as the train moves along a rail track, the method comprising the steps of: sampling magnetic field measurements obtained from a plurality of magnetometer sensors so arranged to be in proximity to a moving wheel or an axle, the sensors arranged to span at least a length sufficient to obtain the magnetic field measurements from the entire wheel or the axle during one complete revolution of the wheel or the axle; and identifying and locating a defect in the wheel or the axle when a sampled magnetic field measurement is equal to or exceeds a threshold value.

Fiber optic sensor method and apparatus

The invention relates to the simultaneous use of an interferometric sensor and a phase-OTDR sensor, both preferably on the same fiber optic cable. The interferometric sensor determines when a a sensed disturbance is of interest, and the phase OTDR sensor locates the sensed disturbance.

Local topical administration formulations containing indoxacarb

Device for supplying gases to a patient

Es wird ein Gerät zur Zuführung von befeuchteten Gasen zu einem Patienten offenbart, das einen Gaszuführungsdurchgang stromabwärts von einer Zuführung für befeuchtete Gase und im Gebrauch stromaufwärts von einem Patienten umfasst, wobei zumindest ein Sensor in die Außenseite der Wand des Durchgangs eingebettet oder darauf angeordnet ist. In bevorzugten Ausführungsformen trennt die Wand des Durchgangs den Sensor bzw. die Sensoren von einer Gasströmung im Durchgang. Im Gebrauch empfängt ein Regler einen Ausgang des Sensors bzw. der Sensoren und leitet von dem Ausgang des Sensors bzw. der Sensoren eine Schätzung einer Eigenschaft der durch den Durchgang strömenden Gase ab oder führt der Zuführung für befeuchtete Gase einen Kontrollausgang gemäß dem Ausgang des Sensors bzw. der Sensoren zu.

Improved nk-based cell therapy

Methods of cancer treatment comprise administration of a natural killer (NK) cell or cell line in combination with an IL-6 antagonist, such as an antibody to IL-6 or its receptor, especially for treatment of cancer expressing IL-6 receptors and in which checkpoint inhibitory receptors, such as PDL-1 and/or PDL-2 are expressed / upregulated during disease.

Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors

The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a variant of human interleukin-3 (hIL-3), which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted, and a hematopoietic growth factor. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.

Microstructure devices and their production

An embossing master ( 20 ) is produced by successively applying epoxy layers ( 2, 10 ) over a silicon substrate ( 1 ) and selectively exposing them to UV to cross-link according to a pattern. Non-exposed epoxy is developed away to leave a pattern of cured epoxy at each level. This provides a multi-level master, with a desired 3D configuration. The master ( 20 ) is then used to emboss a polymer blank to provide a substrate ( 80 ) and a different master is used to emboss a blank to provide a superstrate ( 90 ). The substrate ( 80 ) has aligned socket and channel grooves ( 80, 81 ) and the superstrate ( 90 ) has a socket groove ( 91 ). When the superstrate is mated with the substrate, there is a socket for receiving a fluidic capillary or a detection waveguide. The capillary or waveguide is aligned with the channel for optimum fluidic flow or optical detection.

Portable video communication system

A method and device for adapting a display image on a hand-held portable wireless display and digital capture device. The device includes a camera for capturing a digital video and/or still image of a user, means for adjusting the captured digital image in response to poor image capture angle of said image capture device so as to create a modified captured digital image; and means for transmitting said modified captured digital image over a wireless communication network to a second hand-held portable wireless display and digital capture device.

Methods of using multivariant IL-3 hematopoiesis fusion protein

The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) fused with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.

Breathing assistance apparatus

A nasal cannula assembly is disclosed having a face mount part, in use resting against a user's face, which includes at least one nasal prong capable of being fitted into a person's nares. The cannula assembly also includes a manifold part, in fluid communication with the face mount part, having a single horizontal side gases entry. in particular, this cannula assembly is for supplying heated. humidified gases to a patient suffering from COPD. A tie or lanyard is disclosed for use with a breathing assistance apparatus such as a nasal cannula. face or nasal mask or tracheostomy connector. The tie or lanyard transfers the weight of the conduits supplying gases to the breathing assistance apparatus from the breathing assistance apparatus and distributes it onto the neck of the patient.

Anomaly detector for pipelines

A sensor unit for use in sensing conditions in a pipeline comprises an untethered a ball-shaped surround adapted to roll along the interior surface of a pipeline, and instrument package within the ball-shaped surround. The package contains at least one magnetometer or accelerometer. Preferably, three magnetometers, arranged orthogonally, are present. Other sensors can also be present as required, such as an acoustic sensor to detect leaks and a temperature or chemical sensor. Recording means record the data acquired by the magnetometer(s) or accelerometer and the sensors, and optionally also record a timing trace.

Transdermal porator and patch system and method for using same

A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.

Breathing assistance apparatus

A nasal cannula assembly is disclosed having a face mount part, in use resting against a user's face, which includes at least one nasal prong capable of being fitted into a person's nares. The cannula assembly also includes a manifold part, in fluid communication with the face mount part, having a single horizontal side gases entry. In particular, this cannula assembly is for supplying heated, humidified gases to a patient suffering from COPD. A tie or lanyard is disclosed for use with a breathing assistance apparatus such as a nasal cannula, face or nasal mask or tracheostomy connector. The tie or lanyard transfers the weight of the conduits supplying gases to the breathing assistance apparatus from the breathing assistance apparatus and distributes it onto the neck of the patient.

Device and method to assess impairment of pipeline wall strength

Home data center

Tuning pid parameters using causal models

Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for optimizing parameters of one or more proportional-integral-derivative (PID) controllers. In one aspect, the method comprises repeatedly performing the following: i) selecting a configuration of respective PID parameters for each of the plurality of PID controllers, based on a causal model that measures causal relationships between PID parameters and a measure of success in controlling the system; ii) determining the measure of success of the configuration of respective PID parameters for the plurality of PID controllers in controlling the system; and iii) adjusting, based on the measure of success of the configuration of respective PID parameters for the plurality of PID controllers in controlling the system, the causal model.

Method and apparatus for video surveillance of structures

A method and apparatus is disclosed for detecting unusual conditions relating to a structure, such as collision of an object with the structure or vandalism. The method and apparatus are particularly useful with respect to large structures which are accessible to the public, such as bridges. A continuous video picture is taken of the structure, and the output video is stored for a predetermined period, after which it is discarded. Audio emissions from the structure in a preselected frequency band are detected and compared with records of known usual emissions from said structure in said band. If there are anomalies, the video record is stored for longer than the predetermined period, and the current video output is examined in real time for evidence of an unusual occurrence.

Method and apparatus for obtaining information about the status of a party requesting information about a mobile subscriber

A mobile subscriber can elect to grant permission for the release to a requesting party of information relevant to the mobile subscriber release information. In order to make the decision to provide the information to the requesting party, the mobile subscriber can first determine if the request is being made from a trusted source. If the identity of the requesting party is hidden, the requesting party can be queried to release their identity to be used in conjunction with the permission request to the mobile subscriber.

A illuminator and manafacturing method

An illuminator (1) is manufactured by embossing an aluminium perform to provide a structured substrate base (21) with cavities (25) for LEDs and recesses (26) for tracks. The substrate is anodised to provide an aluminium oxide insulating layer (30) over the structured surface. A metal layer (35) is then applied over the insulating layer (30), and this is etched to leave metal pads in the cavities and tracks in the recesses (26). LEDs (50) are placed in the cavities and they are wire-bonded to the exposed metal tracks. This manufacturing method allows versatility in choice of configuration of illuminator by simple embossing a desired substrate shape. Also, the anodisation provides an excellent and durable insulating layer, which has the major benefit of being conformal with the structured surface.

Patient interface and headgear for a respiratory apparatus

This invention relates to headgear and a patient interface, or components of a headgear or patient interface, such as a nasal cannula. In one embodiment is a size adjustable headstrap to be provided as a headgear or a part thereof, in another is a portion of a headstrap or component for association therewith in which the portion or component facilitates improved location of the strap upon a user's face, in another embodiment is a system for encapsulating or covering a connector from contact with a user's face or facial skin, in another embodiment is a face mount part or body for a patient interface of a particular configuration, and in yet a further embodiment is a gases flow manifold for delivering of gases to a patient interface of a particular configuration for improved patient comfort.

Continuous monitoring of reinforcements in structures

A system for continuously monitoring tensioned reinforcements in a structure (10), such as for example bridges or modern buildings, has a plurality of detectors (D1, D2, D3) randomly and conveniently positioned about the structure (10). The detectors (D1, D2, D3) are responsive to acoustic or seismic energy emissions to produce a signal. The signals associated with reinforcement failure are analyzed (14) to locate the site of reinforcement failure. The system is simple and yet highly sensitive when compared to previously known monitoring systems.

Breathing assistance apparatus with serviceability features

A breathing assistance apparatus is configured with features that improve serviceability of the apparatus. The apparatus can include animations to provide instruction regarding correcting easily-identified fault conditions and to provide instruction regarding routine maintenance routines. The apparatus also can be configured with top level control menus that are obscured in a manner to limit manipulation of the top level control elements by unauthorized users.

Transdermal porator and patch system and method for using same

Abstract A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate. A-1A1 O- I~ aie PA- A Al 19

Multivariant IL-3 hematopoiesis fusion protein

The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) fused with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.

Breathing assistance apparatus

A nasal cannula assembly is disclosed having a face mount part, in use resting against a user's face, which includes at least one nasal prong capable of being fitted into a person's nares. The cannula assembly also includes a manifold part, in fluid communication with the face mount part, having a single horizontal side gases entry. In particular, this cannula assembly is for supplying heated, humidified gases to a patient suffering from COPD. A tie or lanyard is disclosed for use with a breathing assistance apparatus such as a nasal cannula, face or nasal mask or tracheotomy connector. The tie or lanyard transfers the weight of the conduits supplying gases to the breathing assistance apparatus from the breathing assistance apparatus and distributes it onto the neck of the patient.

Substance delivery arrangement for gas therapy device

A mount provides a structure that facilitates coupling of a nebuliser downstream of a humidifier chamber and upstream of a conduit that delivers conditioned breathing gases to a patient or user. The mount can couple together a chamber, a nebulizer and a conduit.

Breathing assistance apparatus

A nasal cannula assembly is disclosed having a face mount part, in use resting against a user's face, which includes at least one nasal prong capable of being fitted into a person's nares. The cannula assembly also includes a manifold part, in fluid communication with the face mount part, having a single horizontal side gases entry. in particular, this cannula assembly is for supplying heated. humidified gases to a patient suffering from COPD. A tie or lanyard is disclosed for use with a breathing assistance apparatus such as a nasal cannula. face or nasal mask or tracheostomy connector. The tie or lanyard transfers the weight of the conduits supplying gases to the breathing assistance apparatus from the breathing assistance apparatus and distributes it onto the neck of the patient.

VIRAL REPLICATION POLYPEPTIDE INHIBITORS.

Catalyzing amino-substituted organosilane ester primers

Methods for bonding a polymer surface (e.g., a fluoropolymer surface) to a substrate, including foam tape substrates, and articles produced thereby. The methods can include using a primer composition having an amidine catalyst in combination with an amino-substituted organosilane ester.

Breathing assistance apparatus with serviceability features

A breathing assistance apparatus comprising a flow generator, a humidifier chamber, a user breathing interface and a display screen. The apparatus is configured to monitor one or more characteristics of use, and upon an occurrence of a triggering event to provide a series of image frames to the display, the series of image frames depicting an animated action configured to instruct a user to make an adjustment to the apparatus based upon the animated action to address the occurrence of the triggering event. WO 2013/151448 PCT/NZ2013/000060 1/21 (9.

Acoustically monitoring concrete vessels and structures

Microcracking in concrete structures is monitored acoustically. The resulting signals can be used to determine corrosion of metal reinforcing wires or rods, or damage occurring from accident or seismic events.

Method for creating view-based representations from multimedia collections

A system that is capable of generating a multiplicity of representations from a set of multimedia objects, each with a potentially different form, is disclosed. In addition, a system that is capable of generating representations that include thematic groupings in addition to the traditional purely sequential groupings is disclosed. Analysis of metadata to generate derived metadata creates a more comprehensive repository of information about media assets. Using the abundance of metadata, embodiments of the methods disclosed teach uniquely grouping and prioritizing media assets into a storyboard, which is in turn mapped onto view-based representations based on a selected output modality.

Breathing assistance apparatus

An apparatus for delivering a flow of gas, has a housing 3202' with a recess, and an outlet port 3210' for a flow of gas. The recess is defined by at least one wall 3256, 3262 that is substantially continuous, gas impermeable, and unbroken, other than a gasflow passage from the recess to the outlet port of the housing.

Respiratory assistance apparatus

A respiratory assistance apparatus has a gases inlet configured to receive a supply of gases, a blower unit configured to generate a pressurised gases stream from the supply of gases; a humidification unit configured to heat and humidify the pressurised gases stream; and a gases outlet for the heated and humidified gases stream. A flow path for the gases stream extends through the respiratory device from the gases inlet through the blower unit and humidification unit to the gases outlet. A sensor assembly is provided in the flow path before the humidification unit. The sensor assembly has an ultrasound gas composition sensor system for sensing one or more gas concentrations within the gases stream.

System and method for data recording and transmission for propeller balancing

A method comprises operating the propeller (29) in-flight, receiving, during operation of the propeller (29) in-flight, vibration data associated with the propeller (29), retrieving, from a non-volatile memory (304) on-board an aircraft (100), configuration data associated with the propeller (29), and transmitting the vibration data and the configuration data to a data processing device (106) configured to determine a balancing solution for the propeller (29) based one the vibration data and the configuration data.

System and method for plasma generation and compression

Examples of a system for generating and compressing magnetized plasma are disclosed. The system comprises a plasma generator with a first closed end and an outlet, and a flux conserving chamber that is in tight fluid communication with the outlet of the plasma generator such that the generated plasma is injected into an inner cavity of the flux conserving chamber. An elongated central axial shaft is also provided such that the central shaft extends through the outlet of the plasma generator into the flux conserver. The end of the central shaft in connected to the flux conserver. A power source that comprises a formation power circuit and a shaft power circuit is provided to provide a formation power pulse to the plasma generator to generate magnetized plasma, and a shaft power pulse to the central axial shaft to generate a toroidal magnetic field into the plasma generator and the flux conserving chamber. The duration of the shaft power pulse is longer than the duration of the formation power pulse to maintain plasma q- profile at a pre-determined range. During plasma compression the shaft power pulse is increased to match the raise of the plasma poloidal field due to the compression and thus maintain the q-profile of the plasma.

Graphical user interface for a flow therapy apparatus

The present disclosure provides to graphical user interfaces for controlling a flow therapy apparatus. The graphical user interface can provide a display of flow therapy treatment information and indicators of a patient's health. The graphical user interface can be configured to display the information associated with the patient on one or more user interface screens.