07-05-2020 дата публикации
Номер: US20200138789A1
Автор:
Cheng Peter Tai Wah,
Corte James R.,
Dhanusu Suresh,
Fang Tianan,
III Robert F.,
Jusuf Sutjano,
Kaltenbach,
Kennedy Lawrence J.,
LI JUN,
Reddigunta Ramesh Babu,
Selvakumar Kumaravel,
Shi Jun,
Shi Yan,
Tao Shiwei,
Walker Steven J,
ZHANG Hao
Принадлежит:
The present invention provides compounds of Formula (I): This application is a divisional application of U.S. patent application Ser. No. 16/038,739, filed Jul. 18, 2018, now allowed, which is a divisional application of U.S. patent application Ser. No. 15/628,104, filed on Jun. 20, 2017, now U.S. Pat. No. 10,071,078, issued Sep. 11, 2018, which claims priority to U.S. Provisional Application Ser. No. 62/352,792, filed Jun. 21, 2016, the entire content of which is incorporated herein by reference.The present invention relates to novel substituted triazole compounds, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of disorders associated with one or more of the lysophosphatidic acid (LPA) receptors.Lysophospholipids are membrane-derived bioactive lipid mediators, of which one of the most medically important is lysophosphatidic acid (LPA). LPA is not a single molecular entity but a collection of endogenous structural variants with fatty acids of varied lengths and degrees of saturation (Fujiwara et al., 2005, 280, 35038-35050). The structural backbone of the LPAs is derived from glycerol-based phospholipids such as phosphatidylcholine (PC) or phosphatidic acid (PA).The LPAs are bioactive lipids (signaling lipids) that regulate various cellular signaling pathways by binding to the same class of 7-transmembrane domain G protein-coupled (GPCR) receptors (Chun, J., Hla, T., Spiegel, S., Moolenaar, W., Editors, 2013, Wiley; ISBN: 978-0-470-56905-4 & Zhao, Y. et al, ()-2013, 1831, 86-92). The currently known LPA receptors are designated as LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6 (Choi, J. W., 2010, 50, 157-186).The LPAs have long been known as precursors of phospholipid biosynthesis in both eukaryotic and prokaryotic cells, but the LPAs have emerged only recently as signaling molecules that are rapidly produced and released by activated cells, notably platelets, to influence target cells by acting on specific cell-surface ...
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