18-10-2018 дата публикации
Номер: US20180297987A1
Принадлежит:
The present invention provides compounds of the Formula (I), or a pharmaceutically acceptable salt thereof, where n and R1 are defined herein, methods of treating patients for liver disease, and processes for preparing the compounds. 3. A compound according to where n is 1 claim 2 , or a pharmaceutically acceptable salt thereof.4. A compound according to where n is 2 claim 2 , or a pharmaceutically acceptable salt thereof.5. A compound according to where R1 is H claim 2 , or a pharmaceutically acceptable salt thereof.6. A compound according to where R1 is —CH claim 2 , or a pharmaceutically acceptable salt thereof.9. The compound according to claim 2 , which is provided as a mono or di hydrochloride addition salt claim 2 , methylsulfonic acid addition salt claim 2 , or a 4-methylbenzenesulfonic acid addition salt.10. A compound according to which is (2E)-3-fluoro-2-({[2-(4-methoxypiperidin-1-yl)pyrimidin-5-yl]oxy}methyl)prop-2-en-1-amine 4-methylbenzenesulfonate.11. A compound claim 8 , which is (2E)-3-fluoro-2-({[2-(4-methoxypiperidin-1-yl)pyrimidin-5-yl]oxy}methyl)prop-2-en-1-amine 4-methylbenzenesulfonate in crystalline form characterized by an X-ray powder diffraction pattern obtained from a CuKα source (k=1.54056 Å) claim 8 , which comprises peaks at:a) 18.6, 19.1, 21.0, 21.9, and 22.4+/−0.2° in 2 theta, orb) 17.6, 11.0, 16.8, 18.6, 19.1, 21.0, 21.9, 22.4 and 26.1+/−0.2° in 2 theta.12. A pharmaceutical composition comprising a compound according to and a pharmaceutically acceptable carrier claim 2 , diluent or excipient.13. A method of treating a patient in need of treatment for non-alcoholic steatohepatitis wherein the method comprises administering to the patient an effective amount of a pharmaceutical composition according to .14. A method of treating a patient in need of treatment for non-alcoholic steatohepatitis wherein the method comprises administering to the patient an effective amount of a compound according to .1517-. (canceled)18. A compound ...
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