03-10-2019 дата публикации
Номер: US20190300522A1
Автор:
Badry BURSULAYA,
Andreas FISCH,
James Paul LAJINESS,
Rainer MACHAUER,
Swapnil MALEKAR,
Hank Michael James PETRASSI,
Farshad RAMAZANI,
Anne-Catherine REMOND,
Thomas ULLRICH,
Peggy USSELMANN,
Eric VANGREVELINGHE,
BURSULAYA BADRY,
FISCH ANDREAS,
LAJINESS JAMES PAUL,
MACHAUER RAINER,
MALEKAR SWAPNIL,
PETRASSI HANK MICHAEL JAMES,
RAMAZANI FARSHAD,
REMOND ANNE-CATHERINE,
ULLRICH THOMAS,
USSELMANN PEGGY,
VANGREVELINGHE ERIC,
BURSULAYA, Badry,
FISCH, Andreas,
LAJINESS, James Paul,
MACHAUER, Rainer,
MALEKAR, Swapnil,
PETRASSI, Hank Michael James,
RAMAZANI, Farshad,
REMOND, Anne-Catherine,
ULLRICH, Thomas,
USSELMANN, Peggy,
VANGREVELINGHE, Eric
Принадлежит:
The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition. 2. The compound according to or a pharmaceutically acceptable salt thereof wherein claim 1 ,{'sub': '1', 'Ris chloro or methyl; and'}{'sub': 2', '2', '5', '6, 'Ris SONRR.'}3. The compound according to or a pharmaceutically acceptable salt thereof wherein{'sub': '5', 'Ris H or methyl; and'}{'sub': 6', '4', '6', '7, 'Ris C-Ccycloalkyl optionally substituted once or more than once with R; and'}{'sub': 7', '1', '3', '1', '3', '1', '3, 'Ris independently selected from hydroxyl, haloC-Calkyl, halogen, and C-Calkyl, hydroxyC-Calkyl.'}4. The compound according to or a pharmaceutically acceptable salt thereof wherein{'sub': 5', '6', '8, 'Rand Rtogether with the N atom to which they are attached form a 4-, 5- or 6-membered heterocyclic non-aromatic ring optionally comprising one additional heteroatom selected from N, O or S, said ring being optionally substituted once or more than once with R; and'}{'sub': 8', '1', '3, 'Ris independently selected from halogen and hydroxyC-Calkyl.'}5. The compound according to or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sub': '1', 'Ris chloro or methyl;'}{'sub': 2', '2', '3, 'Ris NHSOR; and'}{'sub': 3', '4, 'Ris selected from phenyl optionally substituted once or more than once with R;'}{'sub': 3', '6, 'and C-Ccycloalkyl optionally substituted with hydroxyl.'}6. The compound according to or a pharmaceutically acceptable salt thereof claim 5 , wherein{'sub': 4', '1', '3', '1', '3', '1', '3, 'Ris independently selected from halogen, C-Calkoxy, cyano, C-Calkyl, hydroxyl, and haloC-Calkyl; or'}{'sub': 4', '3, 'two Rat adjacent carbon atoms form a 5- or 6-membered heterocyclic non-aromatic ring comprising at ...
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