Composition for improved bone fracture healing

A composition for use as an adjunct in orthopaedic surgery, for example in the treatment of i) delayed fracture healing in bone, manifesting as either a delayed or non-union; ii) a fusion procedure anywhere in the skeletal system, such as a, cranial, spinal, foot and ankle or upper limb and iii) for use as a bone void filler and to enhance bone in-filling in situations of bone loss, such as following combat, e.g., blast injuries, or non-combat related trauma such as road-traffic accidents. The composition comprises i) a parathyroid hormone or a derivative thereof, in an amount of 0.1 ng/ml to 50 ng/ml, (ii) one or more osteoclast inhibitors as defined therein and iii) a bone void filler as defined therein in a solid or liquid phase. The composition may further comprise stem cells. Also disclosed is a method of manufacturing said composition and a kit of parts for the manufacture thereof.

Composition for improved bone fracture healing

Composition for improved bone fracture healing

A composition comprising i.) a parathyroid hormone, or derivative, from 0.1 ng/mL to 50 ng/mL, ii.) a bisphosphonate, or derivative, strontium ranelate, denosumab, or romosozumab, or a combination, from 1 ng/mL to 6000 ng/mL, and iii.) a delivery material for the composition in a solid or liquid phase, which may be selected form calcium sulphate (sulfate), (mono, di or tri) calcium phosphates, calcium carbonates, autograft bone material, (synthetic) allograft, ceramic, calcium sodium phosphosilicate, collagen sponge, carboxymethylcellulose (CMC), polymethyl methacrylate (PMMA), bone cement, or a combination. The bisphosphonate may be selected from zoledronic acid, alendronic acid, etidronate, pamidronate, ibandronic acid, risedronate, clodronate, or a combination. The parathyroid may be parathyroid-related protein (PTHrP), 1-34 or 1-84 recombinant human parathyroid hormone (1-34 rhPTH or 1-84 rhPTH) H05AA03 parathyroid hormone, preotact parathyroid hormone, teriparatide, abaloparatide, ...