VISUAL PROSTHESIS EMPLOYING VIRTUAL NEURAL ELECTRODE ARRAYS

The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. The disclosure further comprises a system for using these arrays to generate time-varying electric fields to stimulate the visual pathways of the brain, including the optic radiations and the occipital cortex, in ways that lead to visual perception. 1. An implantable medical device for electrically stimulating portions of a brain that relate to vision , the implantable medical device comprising:a conformal flexible substrate configured to be inserted into a fluid-filled intracranial cavity proximate to a component of a visual pathway of the brain; anda plurality of electrodes, arranged in a three-dimensional array, fabricated on the substrate.2. The implantable medical device of claim 1 , wherein the plurality of electrodes has an inter-electrode spacing corresponding to a diameter of a neuron.3. The implantable medical device of claim 1 , wherein the inter-electrode spacing corresponds to a neuron cell body with a diameter of about 50 micrometers.4. The implantable medical device of claim 1 , wherein the plurality of electrodes includes more than 100 claim 1 ,000 electrodes per square centimeter.5. The implantable medical device of claim 1 , wherein the plurality of electrodes includes more than 200 claim 1 ,000 electrodes per square centimeter.6. The implantable medical device of claim 1 , wherein the flexible substrate comprises polyimide.7. The implantable medical device of claim 1 , wherein the medical device is implanted into a venous sinus proximate to a visual cortex.8. The ...

Method and System for Population Level Determination of Maximal Aerobic Capacity

A computerized method for determining maximal oxygen uptake for a user with incomplete data with data collected from a plurality of other users with complete data. The maximal oxygen uptake can be determined by computing similarity metrics between an incomplete data set of self-reported and measured data and complete user data sets, and using a weighted sum of the similarity metrics. The results of the maximal oxygen update calculation can be cross-validated with known user data sets.

METHOD FOR DETERMINING AEROBIC CAPACITY

A method of estimating the maximal oxygen uptake of an individual on the basis of heart rate data, biometric data, biomechanical data, and geophysical data is described. These data can be collected as the individual engages in activities requiring various levels of exertion, without modifying those activities from the ordinary manner in which they are performed. In particular, in some embodiments the method described here obviates the conventional need for a laboratory setting when estimating maximal oxygen uptake and the method can be applied to estimate maximal oxygen uptake under more natural conditions than conventional testing protocols requiring treadmills or stationary ergometers typically permit. Furthermore, it is described how such estimates of maximal oxygen uptake can be used to estimate other quantities of interest, including fat and carbohydrate metabolism, lactate production, and water and electrolyte loss during exercise. 1. A computerized method for dynamically measuring maximal oxygen uptake of a user in real-time during aerobic activity , the method comprising:(a) electronically measuring instantaneous heart rate data, instantaneous biomechanical data, and instantaneous geophysical data of the user over a period of time, using one or more sensors;(b) setting an oxygen uptake model for the user and storing the oxygen uptake model in memory of a computer;(c) determining, using the computer, a maximum heart rate of the user and storing the maximum heart rate in memory;(d) determining, using the computer, a plurality of instantaneous oxygen uptake estimates over the period of time based in part on user data including the maximum heart rate, the instantaneous biomechanical data, and the instantaneous geophysical data, wherein the user data is selected and related to the plurality of instantaneous oxygen uptake estimates using the oxygen uptake model;(e) evaluating, using the computer, a relationship between a real-time heart rate relaxation constant ...

Visual prosthesis employing ventricular or endovascular neural electrode arrays

The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. The disclosure further comprises a system for using these arrays to generate time-varying electric fields to stimulate the visual pathways of the brain, including the optic radiations and the occipital cortex, in ways that lead to visual perception.

ENDOVASCULAR ELECTROENCEPHALOGRAPHY (EEG) AND ELECTROCORTICOGRAPHY (ECoG) DEVICES, SYSTEMS AND METHODS

The present disclosure is directed to systems and methods for endovascular electroencephalography (EEG) and electrocorticography (ECoG) systems. In some embodiments, the disclosed systems include electrode arrays that are configured to record and/or stimulate brain tissue via placement within blood vessels of the brain. Venous and arterial EEG and ECoG electrodes, ambulatory EEG and ECoG systems, and transcutaneous access and signal control systems for general and ambulatory endovascular electroencephalography (EEG) and electrocorticography (ECoG), as well as endovascular neural stimulating electrodes are discussed. 1. An implantable medical device comprising:a linear array of electrodes configured for insertion into a blood vessel of a head or brain, the linear array comprising one or more electrodes configured to record or stimulate electrical activity in brain tissue; anda linear substrate including an electrically insulating material supporting the linear array of electrodes.2. The implantable medical device of claim 1 , wherein each of the electrodes comprises at least one of gold claim 1 , silver claim 1 , platinum claim 1 , or platinum-iridium and each of the electrodes has a diameter between about 5 to 25 microns claim 1 , or 25 to 250 microns.3. The implantable medical device of claim 1 , wherein the electrically insulating material comprises a hydrophilic polymer.4. The implantable medical device of claim 1 , wherein the plurality of electrodes are fabricated on the linear array scaffold using lithography claim 1 , 3D printing claim 1 , electroplating claim 1 , or a covalent-type bonding processes.5. The implantable medical device of claim 1 , wherein the one or more electrodes in the linear array are connected to an embedded multiplexing unit designed to function within a blood vessel.6. The implantable medical device of claim 1 , comprising:an embedded multiplexing unit configured to receive one or more of the electrodes from the plurality of electrodes ...

INTRADURAL NEURAL ELECTRODES

Described herein are systems and methods for deploying and recording electrophysiologic signals from electrode arrays located within the dura mater of the brain. The dura matter includes layers of connective tissue, or membrane, that surround the brain and spinal cord. The present disclosure relates to an endovascular electrode system deployed within the blood vessels located between layers of the dura mater, including, for example, the middle meningeal artery and its branches. 1. A medical device comprising:an amplifier and recording apparatus;an electrode array configured for insertion between layers of a dura membrane of the brain, the electrode array comprising a plurality of electrodes, each electrode of the plurality of electrodes configured to record or stimulate electrical activity in brain tissue; anda plurality of electrical traces, wherein each electrical trace is configured to connect an electrode of the electrode array to the amplifier and recording apparatus.2. The medical device of claim 1 , wherein the plurality of electrical traces are separately insulated.3. The medical device of claim 1 , wherein each of the plurality of electrical traces bundle to form a composite wire having a diameter between 6 and 35 thousandths of an inch.4. The medical device of claim 1 , wherein the plurality of electrical traces bundle to form a composite wire having a length of approximately 10 and 30 centimeters.5. The medical device of claim 1 , wherein a subset of the electrical traces among the plurality of electrical traces comprises different lengths.6. The medical device of claim 1 , wherein the diameter for the plurality of electrical traces decreases along the distal end of the plurality of electrical traces.7. The medical device of claim 1 , wherein the amplifier and recording apparatus comprises an embedded multiplexing unit having an analog-to-digital converter.8. The medical device of claim 1 , comprising:a wired connector configured to receive one or more ...

CONFORMAL ELECTRODE ARRAYS FOR ELECTROPHYSIOLOGIC RECORDING AND NEURAL STIMULATION WITHIN THE CEREBRAL VENTRICLES

The present disclosure relates to an array of electrodes on a flexible scaffolding, with the ability to collapse into an axial configuration suitable for deploying through a narrow cylindrical channel. The electrode arrays can be placed into the ventricular system of the brain, constituting a minimally invasive platform for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. 1. An implantable medical device comprising:a flexible substrate comprising a flexible printed circuit board;an array of electrodes mounted on the flexible substrate for recording and stimulating electrical activities within ventricles of a brain; anda conformal scaffolding supporting the flexible substrate.2. The implantable medical device of claim 1 , wherein the array of electrodes is periodic.3. The implantable medical device of claim 1 , wherein the conformal scaffolding is continuous.4. The implantable medical device of claim 1 , wherein the conformal scaffolding comprises;a plurality of flat panels oriented parallel to each other; anda continuous loop of metal wire, wound in a helical pattern across the plurality of parallel panels and longitudinally along the length of the plurality of parallel panels.5. The implantable medical device of claim 4 , wherein the metal wire comprises a shape memory alloy.6. The implantable medical device of claim 5 , wherein the shape memory alloy comprises nitinol.7. The implantable medical device of claim 4 , wherein the plurality of flat panels comprise a center panel and two outer panels.8. The implantable medical device of claim 7 , comprising a stiffener located on a top surface of the center panel.9. The implantable medical device of claim 1 , wherein the flexible printed circuit board comprises polyimide.10. The implantable medical device of claim 1 , wherein each of the ...

METHODS FOR OPTIMALLY MATCHING MUSICAL RHYTHMS TO PHYSICAL AND PHYSIOLOGIC RHYTHMS

A set of methods is described for identifying optimal repetition rates for certain repetitive processes, and identifying musical selections with tempi matched to those optimal rates, so as to use synchrony with musical rhythms as a guide to optimizing performance in repetitive physical, biomechanical, and physiologic processes. 1. A method for determining an optimal repetition rate for a repetitive biomechanical or physiologic process of a user , the method comprising:defining an optimization objective, wherein the optimization objective comprises minimizing, maximizing, or achieving a specific value of a metabolic cost function;storing the optimization objective in memory;monitoring, using a sensor, an actual repetition rate of the biomechanical or physiologic process at a point in time corresponding to the user engaging in the repetitive biomechanical or physiologic process;monitoring, using the sensor, an actual metabolic cost function value of the biomechanical or physiologic process corresponding to the point in time the actual repetition rate is monitored;estimating a functional dependence of the actual metabolic cost function value on the actual repetition rate; andidentifying, sing the functional dependence, an optimum repetition rate for the repetitive biomechanical or physiological process with respect to the optimization objective.2. The method of claim 1 , wherein minimizing claim 1 , maximizing claim 1 , or achieving a specific value of a metabolic cost function comprises minimizing claim 1 , maximizing claim 1 , or achieving a specific value of expended energy during the repetitive biomechanical or physiologic process.3. The method of claim 1 , wherein minimizing claim 1 , maximizing claim 1 , or achieving a specific value of a metabolic cost function comprises minimizing claim 1 , maximizing claim 1 , or achieving a specific value of fat or carbohydrate metabolism during the repetitive biomechanical or physiologic process.4. The method of comprising ...

CONFORMAL ELECTRODE ARRAYS FOR ELECTROPHYSIOLOGIC RECORDING AND NEURAL STIMULATION WITHIN THE CEREBRAL VENTRICLES AND CEREBRAL VASCULATURE

The present disclosure relates to an array of electrodes and integrated electronics on a flexible scaffolding, with the ability to collapse into an axial configuration suitable for deploying through a narrow cylindrical channel. The electrode arrays can be placed into the ventricular system of the brain, blood vessels of the brain, and/or into other body cavities, constituting a minimally invasive platform for precise spatial and temporal localization of electrical activity within the brain and/or body, and precise electrical stimulation of tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain, nervous system, and/or elsewhere in the body. 1. An integrated circuit comprising a size and being configured according to a flexibility requirement for catheter-based delivery to electrophysiologically relevant anatomic targets.2. The integrated circuit of claim 1 , wherein the electrophysiologically relevant anatomic targets comprise a brain.3. The integrated circuit of claim 1 , wherein the electrophysiologically relevant anatomic targets comprise an area of the nervous system.4. The integrated circuit of claim 1 , wherein the electrophysiologically relevant anatomic targets comprise a heart.5. The integrated circuit of claim 1 , wherein the flexibility requirement of the integrated circuit has a tolerable bending radius of approximately 20 cm or less.6. The integrated circuit of claim 1 , wherein a longest rectangular dimension of the size of the integrated circuit is approximately 2 mm or less.7. The integrated circuit of claim 1 , wherein the integrated circuit has a multiplexer array.8. The integrated circuit of claim 7 , wherein the multiplexer array has an aspect ratio 1:r.9. The integrated circuit of claim 8 , wherein 1/r is less than 1.10. The integrated circuit of claim 9 , wherein r is determined based on a total electronics layout area divided by (2 mm).11. The integrated circuit of claim 1 , wherein the ...

ENDOVASCULAR ELECTROENCEPHALOGRAPHY (EEG) AND ELECTROCORTICOGRAPHY (ECoG) DEVICES, SYSTEMS AND METHODS

The present disclosure is directed to systems and methods for endovascular electroencephalography (EEG) and electrocorticography (ECoG) systems. In some embodiments, the disclosed systems include electrode arrays that are configured to record and/or stimulate brain tissue via placement within blood vessels of the brain. Venous and arterial EEG and ECoG electrodes, ambulatory EEG and ECoG systems, and transcutaneous access and signal control systems for general and ambulatory endovascular electroencephalography (EEG) and electrocorticography (ECoG), as well as endovascular neural stimulating electrodes are discussed.

INTRADURAL NEURAL ELECTRODES

Described herein are systems and methods for deploying and recording electrophysiologic signals from electrode arrays located within the dura mater of the brain. The dura matter includes layers of connective tissue, or membrane, that surround the brain and spinal cord. The present disclosure relates to an endovascular electrode system deployed within the blood vessels located between layers of the dura mater, including, for example, the middle meningeal artery and its branches.

Visual prosthesis employing ventricular or endovascular neural electrode arrays

The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. The disclosure further comprises a system for using these arrays to generate time-varying electric fields to stimulate the visual pathways of the brain, including the optic radiations and the occipital cortex, in ways that lead to visual perception.

Device and method for spatiotemporal reconstruction of a moving vascular pulse wave in the brain and other organs

The brain appears to have organized cardiac frequency angiographic phenomena with such coherence as to qualify as vascular pulse waves. Separate arterial and venous vascular pulse waves may be resolved. This disclosure states the method of extracting a spatiotemporal reconstruction of the cardiac frequency phenomena present in an angiogram obtained at faster than cardiac frequency. A wavelet transform is applied to each of the pixel-wise time signals of the angiogram. If there is motion alias then instead a high frequency resolution wavelet transform of the overall angiographic time intensity curve is cross-correlated to high temporal resolution wavelet transforms of the pixel-wise time signals. The result is filtered for cardiac wavelet scale then pixel-wise inverse wavelet transformed. This gives a complex-valued spatiotemporal grid of cardiac frequency angiographic phenomena. It may be rendered with a brightness-hue color model or subjected to further analysis.

Low-power analog architecture for brain-machine interfaces

An ultra-low-power circuit for wireless neural recording and stimulation is provided. The circuit includes a neural amplifier with adaptive power biasing for use in multi-electrode arrays and a decoding and/or learning architecture. An impedance- modulation telemetry system provides low-power data telemetry. Also, the circuit includes a wireless link for efficient power transfer, and at least one circuit for wireless stimulation of neurons.

Endovascular electroencephalography (eeg) and electrocorticography (ecog) devices, systems and methods

The present disclosure is directed to systems and methods for endovascular electroencephalography (EEG) and el ectrocorti cography (ECoG) systems. In some embodiments, the disclosed systems include electrode arrays that are configured to record and/or stimulate brain tissue via placement within blood vessels of the brain. Venous and arterial EEG and ECoG electrodes, ambulatory EEG and ECoG systems, and transcutaneous access and signal control systems for general and ambulatory endovascular electroencephalography (EEG) and electrocorticography (ECoG), as well as endovascular neural stimulating electrodes are discussed.

Endovascular electroencephalography (eeg) and electrocorticography (ecog) devices, systems and methods

Micropower neural amplifier with adaptive input-referred noise

A micropower neural amplifier with adaptive power biasing for use in multi- electrode arrays is provided. The micropower neural amplifier includes a low noise gain stage. The low noise gain stage is implemented using an amplifier and pseudoresistor elements.

Endovascular electroencephalography (eeg) and electrocorticography (ecog) devices, systems and methods

The present disclosure is directed to systems and methods for endovascular electroencephalography (EEG) and electrocorticography (ECoG) systems. In some embodiments, the disclosed systems include electrode arrays that are configured to record and/or stimulate brain tissue via placement within blood vessels of the brain. Venous and arterial EEG and ECoG electrodes, ambulatory EEG and ECoG systems, and transcutaneous access and signal control systems for general and ambulatory endovascular electroencephalography (EEG) and electrocorticography (ECoG), as well as endovascular neural stimulating electrodes are discussed.

Systems and methods for in-body security employing hardware-level systems in bidirectional neural interfaces

Disclosed are systems and methods for circuit- and system-level techniques and approaches for data encryption in scalable, high-bandwidth, bidirectional neural interfaces. In some embodiments, the disclosed systems and methods may be configured to encrypt neural data as close as possible to the data source, and before the data is transmitted out of the body. In some embodiments, the disclosed systems and methods may utilize hardware-based approaches, including those involving modified analog-to-digital converters, and symmetric cryptographic algorithms.

Intradural neural electrodes

Described herein are systems and methods for deploying and recording electrophysiologic signals from electrode arrays located within the dura mater of the brain. The dura matter includes layers of connective tissue, or membrane, that surround the brain and spinal cord. The present disclosure relates to an endovascular electrode system deployed within the blood vessels located between layers of the dura mater, including, for example, the middle meningeal artery and its branches.

Low-power analog-circuit architecture for decoding neural signals

A microchip for performing a neural decoding algorithm is provided. The microchip is implemented using ultra-low power electronics. Also, the microchip includes a tunable neural decodable filter implemented using a plurality of amplifiers, a plurality of parameter learning filters, a multiplier, a gain and time-constant biasing circuits; and analog memory. The microchip, in a training mode, learns to perform an optimized translation of a raw neural signal received from a population of cortical neurons into motor control parameters. The optimization being based on a modified gradient descent least square algorithm wherein update for a given parameter in a filter is proportional to an averaged product of an error in the final output that the filter affects and a filtered version of its input. The microchip, in an operational mode, issues commands to controlling a device using learned mappings.

Data-efficient transfer learning for neural decoding applications

A systems and methods for calibrating a neural device using transfer learning techniques. The methods can include aggregating calibration data across a user population to define a global dataset, identifying similar data segments across the global dataset to define a task-independent training dataset, training a feature extraction model based on the task-independent training dataset to define a trained, task-independent feature extraction model, receiving the calibration data from a user calibrating the neural device, and calibrating a user-specific feature extraction model using the trained, task-independent feature extraction model and the calibration data.

Intradural neural electrodes

Described herein are systems and methods for deploying and recording electrophysiologic signals from electrode arrays located within the dura mater of the brain. The dura matter includes layers of connective tissue, or membrane, that surround the brain and spinal cord. The present disclosure relates to an endovascular electrode system deployed within the blood vessels located between layers of the dura mater, including, for example, the middle meningeal artery and its branches. 21 19924308_1 (GHMatters) P117234.AU.1

High-bandwidth systems for closed-loop deep brain stimulation

A system for performing deep brain stimulation on a brain of a patient is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be inserted to a target stimulation site within the deep brain, includes at least one stimulation electrode. The processor is configured to receive one or more recorded signals from the recording arrays at the target recording site, determine a neurological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the neurological state in order to electrically stimulate the brain.

High-bandwidth systems for closed-loop signal cord stimulation

A system for performing spinal cord stimulation on a subject is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be minimally invasively inserted to a target stimulation site within the nervous tissue, includes stimulation electrodes. The processor is configured to receive more recorded signals from the recording arrays at the target recording site, determine an electrophysiological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the determined electrophysiological state in order to affect the electrophysiological state.

Systems and methods for in-body security employing hardware-level systems in bidirectional neural interfaces

Disclosed are systems and methods for circuit- and system-level techniques and approaches for data encryption in scalable, high-bandwidth, bidirectional neural interfaces. In some embodiments, the disclosed systems and methods may be configured to encrypt neural data as close as possible to the data source, and before the data is transmitted out of the body. In some embodiments, the disclosed systems and methods may utilize hardware-based approaches, including those involving modified analog-to-digital converters, and symmetric cryptographic algorithms.

Systems and methods for in-body security employing hardware-level systems in bidirectional neural interfaces

Disclosed are systems and methods for circuit- and system-level techniques and approaches for data encryption in scalable, high-bandwidth, bidirectional neural interfaces. In some embodiments, the disclosed systems and methods may be configured to encrypt neural data as close as possible to the data source, and before the data is transmitted out of the body. In some embodiments, the disclosed systems and methods may utilize hardware-based approaches, including those involving modified analog-to-digital converters, and symmetric cryptographic algorithms.

ENDOVASCULAR ELECTROENCEPHALOGRAPHY (EEG) AND ELECTROCORTICOGRAPHY (ECoG) DEVICES, SYSTEMS AND METHODS

The present disclosure is directed to systems and methods for endovascular electroencephalography (EEG) and electrocorticography (ECoG) systems. In some embodiments, the disclosed systems include electrode arrays that are configured to record and/or stimulate brain tissue via placement within blood vessels of the brain. Venous and arterial EEG and ECoG electrodes, ambulatory EEG and ECoG systems, and transcutaneous access and signal control systems for general and ambulatory endovascular electroencephalography (EEG) and electrocorticography (ECoG), as well as endovascular neural stimulating electrodes are discussed.

Systems and methods for neural interfaces

Disclosed herein are systems and methods for neural interfaces. Neural interfaces may form minimally invasive and high-scalable bidirectional brain-computer interfaces, which may be used in the treatment of a variety of disorders of the brain and nervous system. Disclosed are methods for a minimally invasive technique for implanting neural interfaces, a neural interface configured to be placed between the brain and the dura and configured to record from and/or stimulate the cortical surface. Also disclosed are methods for attaching a plurality of microelectrode arrays to form a neural interface device, and fabricating neural interfaces including microelectrode arrays and pockets to facilitate their insertion. The disclosed systems and methods also include neural decoding techniques.

Secure interfaces for neural devices

A neural device system that can include a neural device configured to sense data associated with the subject or receive control input, an external device communicably coupled to the neural device, a storage medium communicable coupled to the external device, and one or more communications interfaces between the neural device, the external device, and the storage medium or components thereof, wherein the one or more communications interfaces comprise an encryption protocol.

Self-calibrating neural decoding

Systems and methods related to recalibrating neural devices based on external sensory information are disclosed. The systems can include a neural device configured to sense data associated with the subject or receive control input, a sensor communicably coupled to the external device, the sensor configured to detect a state associated with the subject, and an external device communicably coupled to the neural device and the sensor. The external device can recalibrate a neural decoding model based on the state detected via the sensor, wherein the neural decoding model correlates the data received from the neural device with a corresponding thought or action performed by the subject.

Data-efficient transfer learning for neural decoding applications

A systems and methods for calibrating a neural device using transfer learning techniques. The methods can include aggregating calibration data across a user population to define a global dataset, identifying similar data segments across the global dataset to define a task-independent training dataset, training a feature extraction model based on the task-independent training dataset to define a trained, task-independent feature extraction model, receiving the calibration data from a user calibrating the neural device, and calibrating a user-specific feature extraction model using the trained, task-independent feature extraction model and the calibration data.

Secure interfaces for medical devices

A medical device system that can include a medical device configured to sense data associated with the subject or receive control input, an external device communicably coupled to the medical device, a storage medium communicably coupled to the external device, and one or more communications interfaces between the medical device, the external device, and the storage medium or components thereof, wherein the one or more communications interfaces comprise an encryption protocol.

High-bandwidth systems for closed-loop spinal cord stimulation

A system for performing spinal cord stimulation on a subject is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be minimally invasively inserted to a target stimulation site within the nervous tissue, includes stimulation electrodes. The processor is configured to receive more recorded signals from the recording arrays at the target recording site, determine an electrophysiological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the determined electrophysiological state in order to affect the electrophysiological state.

High-bandwidth systems for closed-loop deep brain stimulation

A system for performing deep brain stimulation on a brain of a patient is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be inserted to a target stimulation site within the deep brain, includes at least one stimulation electrode. The processor is configured to receive one or more recorded signals from the recording arrays at the target recording site, determine a neurological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the neurological state in order to electrically stimulate the brain.

High-bandwidth systems for closed-loop signal cord stimulation

A system for performing spinal cord stimulation on a subject is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be minimally invasively inserted to a target stimulation site within the nervous tissue, includes stimulation electrodes. The processor is configured to receive more recorded signals from the recording arrays at the target recording site, determine an electrophysiological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the determined electrophysiological state in order to affect the electrophysiological state.

High-bandwidth systems for closed-loop deep brain stimulation

A system for performing deep brain stimulation on a brain of a patient is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be inserted to a target stimulation site within the deep brain, includes at least one stimulation electrode. The processor is configured to receive one or more recorded signals from the recording arrays at the target recording site, determine a neurological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the neurological state in order to electrically stimulate the brain.

Secure interfaces for neural devices

A neural device system that can include a neural device configured to sense data associated with the subject or receive control input, an external device communicably coupled to the neural device, a storage medium communicable coupled to the external device, and one or more communications interfaces between the neural device, the external device, and the storage medium or components thereof, wherein the one or more communications interfaces comprise an encryption protocol.

Secure interfaces for neural devices

A neural device system that can include a neural device configured to sense data associated with the subject or receive control input, an external device communicably coupled to the neural device, a storage medium communicable coupled to the external device, and one or more communications interfaces between the neural device, the external device, and the storage medium or components thereof, wherein the one or more communications interfaces comprise an encryption protocol.

Data-efficient transfer learning for neural decoding applications

A systems and methods for calibrating a neural device using transfer learning techniques. The methods can include aggregating calibration data across a user population to define a global dataset, identifying similar data segments across the global dataset to define a task-independent training dataset, training a feature extraction model based on the task-independent training dataset to define a trained, task-independent feature extraction model, receiving the calibration data from a user calibrating the neural device, and calibrating a user-specific feature extraction model using the trained, task-independent feature extraction model and the calibration data.

Secure interfaces for medical devices

A medical device system that can include a medical device configured to sense data associated with the subject or receive control input, an external device communicably coupled to the medical device, a storage medium communicably coupled to the external device, and one or more communications interfaces between the medical device, the external device, and the storage medium or components thereof, wherein the one or more communications interfaces comprise an encryption protocol.

Secure interfaces for medical devices

A medical device system that can include a medical device configured to sense data associated with the subject or receive control input, an external device communicably coupled to the medical device, a storage medium communicably coupled to the external device, and one or more communications interfaces between the medical device, the external device, and the storage medium or components thereof, wherein the one or more communications interfaces comprise an encryption protocol.

Conformal electrode arrays for electrophysiologic recording and neural stimulation within the cerebral ventricles

The present disclosure relates to an array of electrodes on a flexible scaffolding, with the ability to collapse into an axial configuration suitable for deploying through a narrow cylindrical channel. The electrode arrays can be placed into the ventricular system of the brain, constituting a minimally invasive platform for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain.