Instrument for Use in Bone and Method of Use

Instrument for creating voids and channels in bone; and for obtaining samples of bone tissue. The instruments are suitable for reducing fractures in bone and for compacting the bone to create a barrier for leakage upon material injection. The instruments may also be used for bone biopsy and for obtaining samples of bone tissue. Methods for using these instruments are also disclosed.

INTEGRATED WIRELESS DISTRIBUTION AND MESH BACKHAUL NETWORKS

A wireless network using nodes that perform both distribution and backhaul functions is provided. These nodes constitute the key elements of a wireless network that would be deployed and controlled by a wireless network operator. Each node contains a distribution wireless module which is wirelessly coupled to the wireless end user device using a point to multipoint scheme. Also integrated into each node is at least one backhaul wireless module with a directional wireless antenna. Each backhaul wireless module communicates by way of a point to point wireless link with the backhaul module of one other node. The nodes in the wireless network are interconnected to form a mesh backhaul network wherein data traffic can be routed around obstacles that may prevent line of site links. Furthermore, the mesh network allows dynamic routing of data traffic to avoid congestion points or downed links in the network. 1. A wireless network for providing services to a plurality of end users , the network comprising:a plurality of nodes, each node being wirelessly connected to at least one other corresponding node for communication by way of a dedicated point-to-point link, each node comprising at least two wireless backhaul modules for communicating with the at least one other corresponding node, the plurality of nodes comprising:a plurality of routing nodes for routing traffic by using at least one wireless signal, wherein at least one routing node further comprises a wireless distribution module for communicating traffic to at least one corresponding wireless end user device, wherein the at least one routing node receives the at least one wireless signal from the at least one other corresponding node by way of the at least two wireless backhaul modules and transmits at least a portion of the at least one wireless signal to the at least one corresponding end user device by way of the wireless distribution module; andat least one network aggregation node for routing the traffic ...

MOBILE STATION TRAFFIC ROUTING

Devices, networks and methods relating to routing gateway traffic in a mesh network for wireless access. A mesh network has multiple nodes in at least one gateway node through which all incoming and outgoing data traffic pass through. The nodes provide wireless access to wireless and user devices, each of which is associated with anode in the mesh network. Each gateway node contains a record detailing which nodes are providing wireless access to which wireless end user device and which nodes are associated with which end user devices. This record of each end user device's location is periodically updated as the gateway node periodically receives data from the nodes which detail the device is being serviced by which node. Any incoming data traffic destined for an end user device is encapsulated and routed to the proper node servicing that end user device. 2. A gateway node according to wherein said location table is regularly updated based on update data received by said gateway node from said mesh network.3. A gateway node according to wherein said update data is received from nodes in said mesh network.4. A gateway node according to wherein said update data from at least one node comprises a listing of addresses of wireless end user devices being provided wireless coverage by the or each node.5. A gateway node according to wherein said update data is received from another gateway node.6. A gateway according to wherein said control module repackages data packets destined for a roaming destination wireless end user device to provide said data packets with a new destination address based on which node is providing wireless coverage to said roaming destination wireless end user device claim 1 , said roaming destination wireless end user device being a wireless end user device being proceed coverage by a node other than a node associated with said wireless end user device.7. A gateway node according to wherein said gateway node notifies each node in the mesh network ...

SYSTEM AND METHOD FOR FREQUENCY OFFSETTING OF INFORMATION COMMUNICATED IN MIMO-BASED WIRELESS NETWORKS

A communications system includes a multiple-input/multiple-output (MIMO) architecture for high capacity switched mesh networks. The MIMO architecture has a plurality of radio frequency chains. One of the plurality of radio frequency chains is configured to apply a first frequency offset to a base frequency of an output signal to generate a first transmitting frequency; and another of the plurality of radio frequency chains being configured to apply a second frequency offset to the base frequency to generate a second transmitting frequency. The system uses the carrier frequency offset to lock the clock of the master subsystem to the clock of the slave subsystem, thereby enabling bandwidth expansion to be employed on the MIMO data streams. 1. A method of synchronizing a receiver with a transmitter in a communications system comprising a multiple-input/multiple-output (MIMO) architecture , the architecture comprising a first and a second radio frequency chain , the receiver being connected to a controller , the communications system being configured to transceive at least two signals having a predetermined frequency separation , and the method comprising the step of locking a frequency of the receiver to a frequency of the transmitter by configuring the controller to perform the steps of:a) using a packet transmitted by the transmitter and received by the receiver to generate a carrier frequency offset (CFO) estimate;b) adjusting the receiver reference frequency based on the CFO estimate; andc) repeating steps a) and b) until the generated CFO estimate is substantially equal to zero.2. The method of claim 1 , wherein the controller comprises at least one of an open-loop controller; a closed-loop controller; a proportional controller; an integral controller; a derivative controller; and a Kalman filter.3. A method of synchronizing a receiver with a transmitter in a communications system comprising a multiple-input/multiple-output (MIMO) architecture claim 1 , the ...

SYSTEM AND METHOD FOR FREQUENCY OFFSETTING OF INFORMATION COMMUNICATED IN MIMO-BASED WIRELESS NETWORKS

A communications system includes a multiple-input/multiple-output (MIMO) architecture for high capacity switched mesh networks. The MIMO architecture has a plurality of radio frequency chains. One of the plurality of radio frequency chains is configured to apply a first frequency offset to a base frequency of an output signal to generate a first transmitting frequency; and another of the plurality of radio frequency chains being configured to apply a second frequency offset to the base frequency to generate a second transmitting frequency. The system uses the carrier frequency offset to lock the clock of the master subsystem to the clock of the slave subsystem, thereby enabling bandwidth expansion to be employed on the MIMO data streams. 1a) locking a frequency of the receiver to a first high precision reference frequency; andb) locking a frequency of the transmitter to a second high precision reference frequency,wherein each of the first and second high precision reference frequency employs a reference crystal having a maximum frequency error of plus-or-minus 5 parts per million.. A method of synchronizing a receiver with a transmitter in a communications system comprising a multiple-input/multiple-output (MIMO) architecture, the architecture comprising a first and a second radio frequency chain, the communications system being configured to transceive at least two signals having a predetermined frequency separation, and the method comprising the steps of: This application is a divisional of U.S. patent application Ser. No. 12/390,062, filed Feb. 20, 2009, now issued as U.S. Pat. No. 8,254,865, which is a continuation-in-part application of U.S. patent application Ser. No. 11/399,536, filed Apr. 7, 2006, now issued as U.S. Pat. No. 7,881,690, the entire contents of which are incorporated herein by reference.1. Field of the InventionThe present invention relates to communication systems. More specifically, the present invention relates to a system and method for ...

VIRTUAL ACCESS POINT USING SINGLE SERVICE SET IDENTIFIERS

An Access Point (“AP”) apparatus comprising one or more processors containing program code. The program code may be configured to: (i) cause the AP to broadcast a beacon containing a single SSID indentifying the AP; (ii) cause the AP to receive from the STA an query for network information for at least one network operator accessible through the AP; and (iii) cause the AP to send to the STA, for the at least one network operator, a network information description element, in response to the network information query. The AP providing the plural responses broadcasts only a single service set identification (“SSID”). 1. An Access Point (AP) apparatus , comprising: cause the AP to broadcast a beacon containing a single SSID indentifying the AP;', 'cause the AP to receive from an STA an Internet Protocol (IP) Address Type Availability Query for at least one network operator accessible through the AP; and', 'cause the AP to send to the STA, for the at least one network operator, an IP address type availability information element, in response to the IP Address Type Availability Query., 'one or more processors containing program code configured to2. The AP apparatus according to claim 1 , wherein the one or more processors contains program code configured to:cause the AP to receive from the STA, for at least one network operator, a Wide Area Network (WAN) Metrics Query; andcause the AP to send to the STA, for the at least one network operator, a WAN Metrics Information element, in response to the WAN Metrics Query.3. The AP apparatus according to claim 1 , wherein the one or more processors contain program code configured to:cause the AP to receive from the STA, for at least one network operator, a Connection Capability Query; andcause the AP to send to the STA, for the at least one network operator, a connection capability information element, in response to the Connection Capability Query.4. The AP apparatus according to claim 1 , wherein the one or more processors ...

METHOD AND SYSTEM FOR PROVIDING MULTIPLE SERVICES OVER WLAN

A system and method of providing, to a client, access to multiple packet data networks (PDNs), each PDN providing a dedicated PDN connection is disclosed. The client is provided with a number of virtual MAC addresses. Each of the virtual MAC addresses is assigned to a dedicated PDN connection and each dedicated PDN connection is associated with one of the packet data networks. One of the virtual MAC addresses is then delivered via a 4 address MAC frame when the client is communicating with the associated data service. The client may be a Wi-Fi client communicating with the associated data service over a cellular data network. 1. A method of providing , to a client , access to a plurality of Packet Data Networks (PDNs) , each PDN providing a dedicated PDN connection , comprising the steps of:assigning said client a plurality of virtual Media Access Control (MAC) addresses;assigning each of said virtual MAC addresses to a dedicated PDN connection, each dedicated PDN connection being associated with one of said PDNs; andproviding to said client at least one of said virtual MAC addresses via a 4 address MAC frame for said client to communicate with the associated data service.2. The method according to claim 1 , wherein said client comprises a Wi-Fi client claim 1 , and wherein said Wi-Fi client communicates with the associated data service over a cellular data network using the provided 4 address MAC frame.3. The method according to claim 2 , wherein the Wi-Fi client communicates with plural associated data services at the same time.4. The method according to claim 2 , wherein the communicating comprises providing an upstream 4 address MAC frame comprising:a Receiver Address corresponding to an Access Point (AP) Basic Service Set Identifier (BSSID);{'b': '1', 'a Transmitter Address corresponding to a User Equipment (UE) MAC address;'}a Destination Address corresponding to a Trusted WLAN Access Gateway; and{'b': '2', 'a Source Address corresponding to a UE MAC address ...

Polynucleotides encoding alpha-galactosidase a for the treatment of fabry disease

The invention relates to mRNA therapy for the treatment of Fabry disease. mRNAs for use in the invention, when administered in vivo, encode human the α-galactosidase A (GLA), isoforms thereof, functional fragments thereof, and fusion proteins comprising GLA. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of GLA expression and/or activity in subjects. mRNA therapies of the invention further decrease levels of toxic metabolites associated with deficient GLA activity in subjects, namely Gb3 and lyso-Gb3.

Systems and methods for making composite structures

A system for depositing a composite filler material into a channel of a composite structure includes an end-effector configured to extrude a bead of the filler material into the channel. The filler material can comprise a first group of relatively long fibers, a second group of relatively short fibers and a resin. A drive system is configured to move the end-effector relative to the channel, and a position sensor is configured to detect the position of the bead relative to the channel. A controller is configured to operate the drive system in response to the detected position and to operate the end-effector to heat and compress the filler material so as to orient the longer fibers in a substantially longitudinal direction relative to the channel and the shorter fibers in substantially random directions relative to the channel when the bead is extruded into the channel.

Systems and methods for managing state

The disclosure relates to systems and methods for managing state using relatively small assistance from protected hardware. Obfuscated code segments may communicate with supporting protected hardware, store encrypted state values in main memory, and/or communicate via secure channels to secure platform hardware components. In various embodiments, consistent state may be achieved, at least in part, by computing secure tag information and storing the secure tag information in a secure and/or otherwise protected device register. Consistent with embodiments disclosed herein, the tag information may be used to derive keys used to encrypt and/or decrypt stored state information. Tag information may further be used in connection with verification operations prior to using the information to derive associated keys.

VIRTUAL ACCESS POINT USING SINGLE SERVICE SET IDENTIFIERS

An Access Point (“AP”) apparatus comprising one or more processors containing program code. The program code may be configured to: (i) cause the AP to broadcast a beacon containing a single SSID indentifying the AP; (ii) cause the AP to receive from the STA an query for network information for at least one network operator accessible through the AP; and (iii) cause the AP to send to the STA, for the at least one network operator, a network information description element, in response to the network information query. The AP providing the plural responses broadcasts only a single service set identification (“SSID”). 1. (canceled)2. An Access Point (AP) apparatus comprising one or more processors containing instructions configured to cause the AP to:broadcast a single Service Set Identification (SSID) identifying the AP;receive from a user device station (STA), a capability query for at least one of a plurality of operator networks accessible through the AP; andsend to the STA, a capability response for the at least one of the plurality of operator networks, before the STA is associated with the AP.3. The AP apparatus of claim 2 , wherein the capability query is for querying a network characteristic of the at least one of the plurality of operator networks accessible through the AP.4. The AP apparatus of claim 2 , wherein the capability query is an Internet Protocol (IP) Address Type Availability query and the capability response comprises an IP Address Type Availability information element.5. The AP apparatus of claim 2 , wherein the capability query is a Wide Area Network (WAN) Metrics query and the capability response comprises a WAN Metrics information element.6. The AP apparatus claim 2 , wherein the capability query is a Connection Capability Query and the capability response comprises a Connection Capability information element.7. The AP apparatus of claim 2 , wherein the one or more processors contains program code configured to receive the capability query ...

Dynamic and variable learning by determining and using most-trustworthy inputs

A method of providing dynamic and variable learning for an ego vehicle by determining and using most-trustworthy inputs includes determining, based on ambient conditions of an environment of the ego vehicle, a level of trustworthiness of sensor values obtained from one or more ego vehicle sensors. The method also includes determining a level of confidence in an accuracy of an output of a subsystem of the ego vehicle. The output of the subsystem is based on the sensor values. The level of confidence is based on the level of trustworthiness of the sensor values.

Secure Application Distribution Systems and Methods

Systems and methods are described that use software diversification techniques to improve the security of mobile applications. Embodiments of the disclosed systems and methods may, among other things, facilitate secure application distribution through deployment of diverse of applications in an application distribution channel. Software diversification consistent with certain disclosed embodiments may mitigate large-scale automated circumvention of security protections by presenting attacking malware moving and/or otherwise unpredictable diverse targets.

Systems and methods for making composite structures

A system for depositing a composite filler material into a channel of a composite structure includes an end-effector configured to extrude a bead of the filler material into the channel. The filler material can comprise a first group of relatively long fibers, a second group of relatively short fibers and a resin. A drive system is configured to move the end-effector relative to the channel, and a position sensor is configured to detect the position of the bead relative to the channel. A controller is configured to operate the drive system in response to the detected position and to operate the end-effector to heat and compress the filler material so as to orient the longer fibers in a substantially longitudinal direction relative to the channel and the shorter fibers in substantially random directions relative to the channel when the bead is extruded into the channel.

Precipitation sensor

A precipitation sensor including a cantilevered sensor member having a cantilevered portion and an upper and a lower surface extending on opposite sides of the cantilevered portion. The sensor member can receive falling precipitation on the upper surface and vibrate when struck by such precipitation. The cantilevered portion can have outer perimeter edges that are sloped downwardly for shedding the precipitation off the cantilevered portion. An electromechanical sensor can be incorporated with at least a part of the cantilevered portion of the sensor member for sensing the vibrations of the sensor member caused by the precipitation, and generating an electrical response from which precipitation properties can be determined. A support structure can be connected to the lower surface of the cantilevered portion at about a central region of the sensor member for supporting the sensor member. The cantilevered portion extends outwardly beyond the support structure.

Signal-sensor polynucleotides for the alteration of cellular phenotypes

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.

Alternative nucleic acid molecules containing reduced uracil content and uses thereof

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.

Compositions and methods for tolerizing cellular systems

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of molecules for tolerizing cellular systems.

Compositions and methods for neuraminidase detection and quantitification

Provided herein are compounds having the structure of Formulas A-D and compositions thereof for use in the detection and quantification of viral neuraminidase. In particular, the compounds may be useful for the evaluation of viral strains and for vaccine evaluation.

Systems and methods for switching between a primary driver and a secondary driver for a vehicle

A vehicle system is provided. The vehicle system includes a first driving input device, a second driving input device, and an autonomous vehicle control module. The autonomous vehicle control module is configured to monitor a driving behavior of a first driver operating the first driving input and to automatically transfer vehicle control of a vehicle from the first driver to the second driver when one or more requirements are met based on the driving behavior of the first driver. The autonomous vehicle control module is further configured to analyze switching of vehicle control between the first driver and the second driver.

Systems, methods and vehicles for determining wrong direction driving

Systems, vehicles and methods for determining wrong direction driving are disclosed. In one embodiment, a system for determining a vehicle traveling in a wrong direction includes one or more sensors that produce sensor data, one or more processors, and one or more non-transitory computer-readable medium storing computer readable-instructions. When the computer-readable instructions are executed by the one or more processors, the computer-readable instructions cause the one or more processors to determine one or more lanes within a roadway using the sensor data, determine a direction of travel of the one or more lanes using the sensor data, and identify a non-compliant vehicle traveling in a direction in the one or more lanes that is different from the determined direction of travel in the one or more lanes.

Methods and System for Predicting Driver Awareness of a Feature in a Scene

An embodiment takes the form of a training server that presents a video comprising a plurality of frames, each comprising a respective scene representation of a scene at a respective time. The scene representations comprise respective representations of a feature in the scene. The training server presents a respective gaze representation of a driver gaze for each frame. The gaze representations comprise respective representations of driver gaze locations at the times of the respective scene representations. The training server generates an awareness prediction via a neural network based on the driver gaze locations, the awareness prediction reflecting a predicted driver awareness of the feature. The training server receives an awareness indication associated with the video and the gaze representations, and trains the neural network based on a comparison of the awareness prediction with the awareness indication.

Suppressors of Premature Termination Codons as Therapeutics and Methods for Their Use

This invention discloses the use of aminoglycoside antibiotics such as gentamicin B1 to suppress premature termination codons during translation and promote the full length read-through of transcripts such as p53 that incorporate nonsense mutations and to treat disease conditions such as cancer caused by such genetic mutations.

Preparation of lipid nanoparticles and methods of administration thereof

The present disclosure provides methods of producing lipid nanoparticle (LNP) formulations and the produced LNP formulations thereof. The present disclosure also provides therapeutic and diagnostic uses related to the produced LNP formulations.

Distributed transistor-based power supply for supplying heat to a structure

A heating system includes a structure to be heated, and a heating apparatus disposed to heat the structure. The heating apparatus includes a housing member, a plurality of resonant frequency power sources, and a plurality of associated controls. The plurality of resonant frequency power sources are attached to the housing member. The plurality of associated controllers is configured to separately operate the plurality of resonant frequency power sources at resonant frequencies matching heating requirements of the structure.

Fiber Placement System and Method with Modulated Laser Scan Heating

A fiber placement system including a compaction roller rotatable about an axis of rotation, the compaction roller at least partially defining a compaction nip region, and a laser heating assembly including a laser that emits a beam of electromagnetic radiation and a scan head defining a scan field, the scan field being aligned with the compaction nip region, wherein the scan head scans the beam within the scan field.

Molybdenum composite hybrid laminates and methods

A method of forming a molybdenum composite hybrid laminate is disclosed. The method includes treating a surface of each of a plurality of molybdenum foil layers. The method further includes interweaving the surface treated molybdenum foil layers with a plurality of composite material layers. The method further includes bonding with an adhesive layer each of the surface treated molybdenum foil layers to adjacent composite material layers to form a molybdenum composite hybrid laminate having improved yield strength.

Combined refrigeration and power plant

A combined refrigeration and power plant. The power plant comprises an internal combustion engine an air cycle machine refrigerator driven by the internal combustion engine and configured to refrigerate atmospheric air to provide working fluid to combined refrigeration and power generation cycle, a refrigerated air storage unit configured to store working fluid produced by the air cycle machine refrigerator; and first and second heat exchangers. The first heat exchanger arrangement is configured to exchange heat between a device to be cooled and the working fluid, and the second heat exchanger arrangement is configured to exchange heat between the working fluid downstream of the first heat exchanger in the combined refrigeration and power generation cycle and waste heat from the internal combustion engine; and a generator turbine configured to receive heated working fluid from the second heat exchanger arrangement, and configured to power an electrical generator.

Secure application distribution systems and methods

Systems and methods are described that use software diversification techniques to improve the security of mobile applications. Embodiments of the disclosed systems and methods may, among other things, facilitate secure application distribution through deployment of diverse of applications in an application distribution channel. Software diversification consistent with certain disclosed embodiments may mitigate large-scale automated circumvention of security protections by presenting attacking malware moving and/or otherwise unpredictable diverse targets.

Vehicles and systems for predicting road agent behavior based on driving style

An embodiment takes the form of a method carried out by a vehicle. The vehicle identifies a characteristic of a road agent. Based on the identified characteristic, the vehicle determines a driving style of the road agent. The vehicle predicts a behavior of the road agent based on the determined driving style.

Vehicle stowage bin assemblies having weight sensors

Vehicle stowage bin assemblies having weight sensors

A stowage bin assembly is within an interior cabin of a vehicle. The stowage bin assembly includes a weight sensor that is configured to detect the weight of the stowage bin assembly.

Electronic stowage bin control systems and methods

Electronic stowage bin control systems and methods

A stowage bin control system and method for a vehicle includes at least one stowage bin assembly that are configured to be selectively moved between an open position and a closed position, and a master control device that is separate and distinct from the stowage bin assemblies. The master control device is communicatively coupled to the stowage bin assemblies and is configured to operate the stowage bin assemblies.

Illuminated stowage bin assemblies within vehicles

A stowage bin assembly of a vehicle includes one or more interior light-emitting elements that are configured to illuminate a baggage retaining chamber of the stowage bin assembly. The stowage bin assembly is within an interior cabin of the vehicle.

Touch-free operable stowage bin assemblies

A stowage bin assembly includes a latch that is configured to selectively lock and unlock the stowage bin assembly, and a sensor in communication with the latch. The sensor is configured to be engaged to lock, unlock, open, and/or close the stowage bin assembly without the latch or the sensor being touched.

Vehicles including electronic stowage bin control systems

A vehicle includes an interior cabin, and a stowage bin control system. The stowage bin control system includes a plurality of stowage bin assemblies within the interior cabin. The plurality of stowage bin assemblies are configured to be selectively moved between an open position and a closed position. A master control device is separate and distinct from the plurality of stowage bin assemblies. The master control device is communicatively coupled to at least one of the plurality of stowage bin assemblies through wireless connections and is configured to operate the at least one of the plurality of stowage bin assemblies.

Coating production systems and methods with ultrasonic dispersion and active cooling

Coating production systems and methods which include ultrasonic dispersion and active cooling. The system includes a mixing reservoir and an ultrasonic disperser for ultrasonically dispersing an additive with another coating component within the mixing reservoir. The system also includes a heat exchanger in communication with the mixing reservoir to receive a mixture of the additive and another coating component from the mixing reservoir. The mixture is cooled by thermal energy transfer from the mixture to the heat exchanger. The cooled mixture is returned to the mixing reservoir.

Compound for inhibiting mitotic progression

Integrated system for filtering and dispensing fluid having fill, dispense and bubble purge strokes

An integrated system and method are disclosed for filtering a fluid and for dispensing a desired volume of the fluid. The integrated system includes a feed pump sub-assembly for receiving fluid and for directing the fluid through a filter. A filtration sub-assembly is joined with the feed pump sub-assembly for receiving fluid from the feed pump sub-assembly and for housing the filter. A dispense pump sub-assembly is integrally joined with the filtration sub-assembly and defines a dispense chamber for receiving filtered fluid from the filtration sub-assembly. The dispense pump sub-assembly includes a dispensing means which is moveable from a fill position to a purge position for purging at least a portion of any gas bubbles from the dispense chamber. The gas bubbles are purged through a purge outlet disposed above a fluid inlet and a fluid outlet of the dispense chamber. The dispensing means is also moveable from the purge position to a dispense position for dispensing a desired volume of the fluid from the integrated system.

Process gas distribution system and method with supervisory control

A plurality of gas flow control units in cabinets are connected to distribute process gas, on demand, to a plurality of utilization locations known as "tool" locations in a semi-conductor manufacturing plant. Each gas flow control unit is connected to a single tool interface controller over a single communications cable. The status and operational characteristics of the individual units are communicated through the tool interface controller to a supervisory control computer by means of polling. Each flow control cabinet has its own data processor, and can be operated alone. Also, the supervisory computer can be used to operate each cabinet, as well as to monitor operations of the system. Gas demand and other signals are communicated from each tool location to the control units through a single cable connected to the interface controller, thus reducing the original wiring cost. Changing the communications path to accompany a change of the tool to which a given conduit in one of the cabinets delivers its gas can be done quickly, in software, with a few keystrokes. Mechanical re-wiring is not needed.

DEVICE TO INTENSIFY FLUORESCENCE AND KINETICS AND METHODS FOR USING THE DEVICE.

UN PORTADOR TENIENDO AL MENOS UN SOPORTE MEJORANDO LA ENERGIZACION Y FLUORESCENCIA Y UNA SUSTANCIA SECA SELECCIONADA DE ENTRE EL GRUPO COMPUESTO POR: SUSTRATOS FLUOROGENICOS, B-METILOLUMBERIFERONA, CUMARINA 7-AMINO-4 METILO, B-NAFTAFENILOAMINA, FLUORESCEINA, Y RESORCINOL DEPOSITADO SOBRE EL SOPORTE DEMOSTRANDO UNA MEJORA SUSTANCIAL DE LA ENERGIZACION Y FLUORESCENCIA DE SISTEMAS DE HIDROLISIS SOBRE LIQUIDOS. CUANDO EL DISPOSITIVO TIENE UNA PLURALIDAD DE SOPORTES Y LOS SOPORTES TIENEN DIFERENTES SUSTRATOS FLUOROGENICOS PUEDE DETERMINARSE EN LA SUSPENSION UN PERFIL DEL NIVEL DE REACCION DE UN ENCIMA DE UN MICRO ORGANISMO Y SE PUEDE USAR PARA IDENTIFICAR EL ORGANISMO. EL DISPOSITIVO TAMBIEN SE PUEDE USAR PARA CARACTERIZAR ENCIMAS EXPRESADOS POR OTROS ESPECIMENES BIOLOGICOS. A CARRIER HAVING AT LEAST ONE SUPPORT IMPROVING ENERGIZATION AND FLUORESCENCE AND A DRY SUBSTANCE SELECTED FROM AMONG THE GROUP COMPOSED BY: SUBSTRATES FLUOROGENIC, B-METHYLUMBERIFERONE, CUMARINA 7-AMINO-BORINA, BURIN-BORINA SUPPORT DEMONSTRATING A SUBSTANTIAL IMPROVEMENT OF THE ENERGIZATION AND FLUORESCENCE OF HYDROLYSIS SYSTEMS ON LIQUIDS. WHEN THE DEVICE HAS A PLURALITY OF SUPPORTS AND THE SUPPORTS HAVE DIFFERENT FLUOROGENIC SUBSTRATES, A PROFILE OF THE REACTION LEVEL OF A MICRO-ORGANISM ABOVE CAN BE DETERMINED TO IDENTIFY THE ORGAN. THE DEVICE CAN ALSO BE USED TO CHARACTERIZE TABLES EXPRESSED BY OTHER BIOLOGICAL SPECIMENS.

High power fiber gain media system achieved through power scaling via multiplexing

Power scaling by multiplexing multiple fiber gain sources with different wavelengths, pulsing or polarization modes of operation is achieved through multiplex combining of the multiple fiber gain sources to provide high power outputs, such as ranging from tens of watts to hundreds of watts, provided on a single mode or multimode fiber.

Compositions and methods of altering cholesterol levels

The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.

Microsystem platform and its use

A microsystem platform comprises a substrate in the form of a disc, which has a first flat, planar surface (31) comprising a multiplicity of microchannels and at least one sample input means (11) embedded therein. The disc has also a second flat, planar surface (27) opposite to the first surface. The sample input means (11) of the disc and its microchannels are connected and in fluidic contact with each other and with air vents (29,33,34,35). The disc has a centrally located aperture that is designed to be engaged by a spindle of a micromanipulation device that induces rotational motion to the microsystem platform when that is placed on the spindle. By such rotational motion, a volume of a fluid within the microchannels of the platform is moved through said microchannels by centripetal force arising from rotational motion of the platform sufficient to move the fluid through the microchannels. Also disclosed are important elements of a microsystem platform, such as reaction chambers (16,22,24), microvalves (15,17,19,21, 23,25), inlet and outlet ports (11,32), as well as a system for performing microanalytical and microsynthetic assays of biological, chemical, environmental and industrial samples. This system comprises a microsystem platform and a micromanipulation device designed to rotate the first.

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system

This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The microsystem platforms of the invention are also optionally provided having system informatics and data acquisition, analysis and storage and retrieval informatics encoded on the surface of the disk opposite to the surface containing the fluidic components. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.

An affinity binding-based system for detecting particulates in a fluid

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays

This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays.

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system

This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the invention is also provided.

Enhanced uplink operation in soft handover

【課題】ソフトハンドオーバ時のワイヤレス通信システムにおける機能強化されたアップリンク（ＥＵ）動作のための方法を提供する。【解決手段】本システムは、無線送受信ユニット（ＷＴＲＵ）、少なくとも２つのノードＢ、および無線ネットワークコントローラ（ＲＮＣ）を備える。１つのノードＢをプライマリノードＢとして指定し、そのプライマリノードＢが、アップリンクスケジュール作成およびハイブリッド自動再送要求（Ｈ−ＡＲＱ）を含むソフトハンドオーバ時のＥＵ動作を制御する。ソフトバッファの破壊は、ソフトハンドオーバ時に、プライマリノードＢがＨ−ＡＲＱを制御することにより、回避される。代案として、ＲＮＣが、Ｈ−ＡＲＱを含むソフトハンドオーバ時のＥＵ動作を制御する。この場合、ＲＮＣは、各ノードＢのエラーチェック結果に基づいて、最終的な肯定応答／否定応答（ＡＣＫ／ＮＡＣＫ）の決定を生成する。【選択図】図１Ａ

Constraining ring for a hip cup

The hip cup of this invention includes a porous metal outer shell, preferably formed from fiber metal, and a compression molded polyethylene component defining an articulating surface at its center for contact with a prosthetic femoral head. The porous outer shell is placed within a mold and the polyethylene component is compression molded within the shell. To prevent the porous shell from collapsing or distorting about its equatorial edge (and thereby distorting the articulating surface) a constraining ring is fitted over the edge of the shell prior to the molding of the polyethylene component. The ring is held in contact with the shell by the molded polyethylene. The constraining ring prevents the edges of the shell from radially distorting during impaction into a prepared acetabulum or during use.

Secure application distribution systems and methods

Systems and methods are described that use software diversification techniques to improve the security of mobile applications. Embodiments of the disclosed systems and methods may, among other things, facilitate secure application distribution through deployment of diverse of applications in an application distribution channel. Software diversification consistent with certain disclosed embodiments may mitigate large-scale automated circumvention of security protections by presenting attacking malware moving and/or otherwise unpredictable diverse targets.

Method and apparatus for compressing images

A system and method is disclosed that compresses and decompresses images. The compression system and method includes an encoder which compresses images and stores such compressed images in a unique file format, and a decoder which decompresses images. The encoder optimizes the encoding process to accommodate different image types with fuzzy logic methods that automatically analyze and decompose a source image, classify its components, select the optimal compression method for each component, and determine the optimal parameters of the selected compression methods. The encoding methods include: a Reed Spline Filter, a discrete cosine transform, a differential pulse code modulator, an enhancement analyzer, an adaptive vector quantizer and a channel encoder to generate a plurality of data segments that contain the compressed image. The plurality of data segments are layered in the compressed file to optimize the decoding process. The first layer allows the decoder to display the compressed image as a miniature or a coarse quality full sized image, the decoder then adds additional detail and sharpness to the displayed image as each new layer is received. The decoder uses optimal decompression methods to expand the compressed image file.

Alternative nucleic acid molecules containing reduced uracil content and uses thereof

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.

Alternative nucleic acid molecules containing reduced uracil content and uses thereof

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.

Alternative nucleic acid molecules containing reduced uracil content and uses thereof

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.

Enhanced uplink operation in soft handover

【課題】ソフトハンドオーバ時のワイヤレス通信システムにおける機能強化されたアップリンク（ＥＵ）動作のための方法を提供する。【解決手段】本システムは、無線送受信ユニット（ＷＴＲＵ）、少なくとも２つのノードＢ、および無線ネットワークコントローラ（ＲＮＣ）を備える。１つのノードＢをプライマリノードＢとして指定し、そのプライマリノードＢが、アップリンクスケジュール作成およびハイブリッド自動再送要求（Ｈ－ＡＲＱ）を含むソフトハンドオーバ時のＥＵ動作を制御する。ソフトバッファの破壊は、ソフトハンドオーバ時に、プライマリノードＢがＨ－ＡＲＱを制御することにより、回避される。代案として、ＲＮＣが、Ｈ－ＡＲＱを含むソフトハンドオーバ時のＥＵ動作を制御する。この場合、ＲＮＣは、各ノードＢのエラーチェック結果に基づいて、最終的な肯定応答／否定応答（ＡＣＫ／ＮＡＣＫ）の決定を生成する。【選択図】図１Ａ

Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions

Chimeric polynucleotides

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules.

Circular polynucleotides

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.

Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells

Methods, including culture media conditions, which provide for ex vivo human stem cell division and/or the optimization of human hematopoietic progenitor cell cultures and/or increasing the metabolism or GM-CSF secretion or IL-6 secretion of human stromal cells are disclosed. The methods rely on culturing human stem cells and/or human hematopoietic progenitor cells and/or human stromal cells in a liquid culture medium which is replaced, preferably perfused, either continuously or periodically, at a rate of 1 ml of medium per ml of culture per about 24 to about 48 hour period, and removing metabolic products and replenishing depleted nutrients while maintaining the culture under physiologically acceptable conditions. Optionally growth factors are added to the culture medium.

System and method for frequency offsetting of information communicated in MIMO-based wireless networks

A communications system includes a multiple-input/multiple-output (MIMO) architecture for high capacity switched mesh networks. The MIMO architecture has a plurality of radio frequency chains. One of the plurality of radio frequency chains is configured to apply a first frequency offset to a base frequency of an output signal to generate a first transmitting frequency; and another of the plurality of radio frequency chains being configured to apply a second frequency offset to the base frequency to generate a second transmitting frequency. The system uses the carrier frequency offset to lock the clock of the master subsystem to the clock of the slave subsystem, thereby enabling bandwidth expansion to be employed on the MIMO data streams.

Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

Circular polynucleotides

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.

Terminally modified RNA

The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.

Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture

Methods, including culture media conditions, which provide for in vitro human stem cell division and/or the optimization of human hematopoietic progenitor cell cultures and/or increasing the metabolism or GM-CSF secretion or IL-6 secretion of human stromal cells and/or a method for assaying the effect of a substance or condition on a human hematopoietic cell population, and/or depleting the malignant cell or T-cell and B-cell content of a human hematopoietic cell population are disclosed. The methods rely on culturing human stem cells and/or human hematopoietic progenitor cells and/or human stromal cells in a liquid culture medium which is replaced, preferably perfused, either continuously or periodically, at a rate of 1 ml of medium per ml of culture per about 24 to about 48 hour period, and removing metabolic products and replenishing depleted nutrients while maintaining the culture under physiologically acceptable conditions. Optionally, growth factors are added to the culture medium. The disclosed culture conditions afford improved methods for bone marrow transplantation.

Affinity binding-based system for detecting particulates in a fluid

This invention provides methods an apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection means for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.

Graphic display configuration framework for unified process control system interface

Integrierte grafische Benutzeroberfläche für eine Prozesssteuerungsumgebung, wobei die Benutzeroberfläche umfasst: grafische Benutzeroberflächen- und separate Funktionen für Betriebs-, Wartungs-, Konfigurations-, Simulations- und Verwaltungsfunktionen einer Prozessanlage, Echtzeitschnittstellenfunktionen für Betriebs-, Wartungs-, Konfigurations- und Simulationsfunktionen, wobei die Oberfläche eine Echtzeitanzeige von mehr als einer der Betriebs-, Wartung-, Konfigurations- und Simulationsfunktionen bereitstellt. Integrated graphical user interface for a process control environment, the user interface comprising: graphical user interface and separate functions for operation, maintenance, configuration, simulation and management functions of a process plant, Real-time interface functions for operating, maintenance, configuration and simulation functions, the interface providing a real-time display of more than one of the operating, maintenance, configuration and simulation functions.

Methods, compositions and devices for growing human hematopoietic cells

Methods, compositions and devices are provided for the growth of hematopoietic cells in culture. Bioreactors are provided in which diverse cell types are simultaneously cultured in the presence of appropriate levels of nutrients and growth factors substantially continuously maintained in the bioreactor while removing undesirable metabolic products. This simultaneous culture of multiple cell types is required for the successful reconstruction of hematopoietic tissue ex vivo. At least one growth factor is provided through excretion by transfected stromal cells, particularly heterologous cells. Means are provided for maintaining the stromal cells and hematopoietic cells separately, to allow for early removal of the hematopoietic cells.

Hematopoietic cells: compositions and methods

Processes, compositions and uses of hematopoietic cells are disclosed. Hematopoietic cells are cells which can differentiate into mature blood cells when co-cultured with osteoblasts. Specifically, a process for propagating and maintaining the immature morphology of a hematopoietic cell by co-culturing with osteoblasts is disclosed. The osteoblasts provide cytokines and/or a microenvironment which propagates and maintains the immature morphology of a hematopoietic cell. Hematopoietic cells are useful in the treatment of certain blood related disorders and are useful for treatment of patients in need of hematopoietic cells.

Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells

Methods, compositions and devices are provided for the growth of human stem and/or hematopoietic cells in culture. Bioreactors are provided in which diverse cell types are simultaneously-cultured in the presence of appropriate levels of nutrients and growth factors substantially continuously maintained in the bioreactor while removing undesirable metabolic products. This simultaneous culture of multiple cell types successfully reconstructs hematopoietic tissue ex vivo. Optionally, at least one growth factor is provided through excretion by transfected stromal cells, particularly heterologous cells. The stromal cells and hematopoietic cells may be maintained separately, and both the adherent and non-adherent cells harvested.

Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells

Methods, including culture media conditions, which provide for ex vivo human stem cell division and/or the optimization of human hematopoietic progenitor cell cultures and/or increasing the metabolism or GM-CSF secretion or IL-6 secretion of human stromal cells are disclosed. The methods rely on culturing human stem cells and/or human hematopoietic progenitor cells and/or human stromal cells in a liquid culture medium which is replaced, preferably perfused, either continuously or periodically, at a rate of 1 ml of medium per ml of culture per about 24 to about 48 hour period, and removing metabolic products and replenishing depleted nutrients while maintaining the culture under physiologically acceptable conditions. Optionally growth factors are added to the culture medium.

Systems and methods for mapping virtual radio instances into physical volumes of coherence in distributed antenna wireless systems

Systems and methods are described for mapping Virtual Radio Instances (VRIs) into physical volumes of coherence in a Multiple Antenna System (MAS) with Multi-User (MU) transmissions (“MU-MAS”). These mapping methods enable communications through simultaneous non-interfering data streams in the same frequency band between the MU-MAS and multiple users, within their own volume of coherence. As the users move, their VRIs follow their respective volumes of coherence via teleportation to adjacent MU-MAS networks, thereby eliminating the need for handoffs as in conventional cellular systems and unnecessary control data overhead. frequency band between the MU-MAS and multiple users, within their own volume of coherence. As the users move, their VRIs follow their respective volumes of coherence via teleportation to adjacent MU-MAS networks, thereby eliminating the need for handoffs as in conventional cellular systems and unnecessary control data overhead.

Cladding-pumped MOPA structure

A master oscillator and power amplifier configuration for a high power cladding- pumped laser structure, and a method of making same, is disclosed. The laser structure comprises a single mode core having at least one oscillator defined therein, and a first and second cladding layer for waveguiding and radiation retention. The core is doped with refractive-index modifying dopants, in addition to ionized rare earth elements. The refractive-index modifying dopants facilitate writing one or more spaced pairs of index gratings in the core, each pair defining an oscillator. Oscillator cavity length is determined by the desired mode spacing and is less than one-half of the single mode core length. The index gratings are formed via a ultraviolet light-induced refractive index change in the core, which index change varies periodically along the core. The periodic variation is created by projecting an interference pattern on the core.

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system

This system provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the system provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the system are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the system is also provided.

VIDEO DISPLAY SYSTEM

SELON L'INVENTION, LE SYSTEME COMPREND: -UNE PREMIERE MEMOIRE 35 POUR MEMORISER DES DONNEES REPRESENTANT UNE PLURALITE D'OBJETS DEVANT ETRE AFFICHES, LES DONNEES DE CHAQUE OBJET ETANT MEMORISEES DANS DES EMPLACEMENTS DE CETTE PREMIERE MEMOIRE ACCESSIBLES DE FACON CONTIGUE, ET CETTE PREMIERE MEMOIRE PERMETTANT DE MEMORISER UN NOMBRE VARIABLE DE BITS PAR PIXEL, DE SORTE QU'UN OBJET PUISSE ETRE MEMORISE SUR UN NOMBRE D'EMPLACEMENTS DIFFERENT DE CELUI DES AUTRES OBJETS; UNE SECONDE MEMOIRE POUR MEMORISER DES ATTRIBUTS DE CHACUN DES OBJETS; -UN PREMIER MOYEN DE COMMANDE 48 POUR RECEVOIR CES ATTRIBUTS EN PROVENANCE DE LA SECONDE MEMOIRE, DE MANIERE A CONTROLER L'ACCES DESDITES DONNEES DE LA PREMIERE MEMOIRE, CE PREMIER MOYEN DE COMMANDE ETANT RELIE A LA PREMIERE ET A LA SECONDE MEMOIRE; -UN TAMPON 50 POUR RECEVOIR LESDITES DONNEES DEPUIS LA PREMIERE MEMOIRE, CE TAMPON ETANT RELIE A LA PREMIERE MEMOIRE ET AU PREMIER MOYEN DE COMMANDE. ACCORDING TO THE INVENTION, THE SYSTEM INCLUDES: A FIRST MEMORY 35 FOR STORING DATA REPRESENTING A PLURALITY OF OBJECTS TO BE DISPLAYED, THE DATA OF EACH OBJECT BEING STORED IN LOCATIONS OF THIS FIRST MEMORY, AND CONTIGUALLY ACCESSIBLE. MEMORY ALLOWING TO STORE A VARIABLE NUMBER OF BITS PER PIXEL, SO THAT AN OBJECT CAN BE STORED IN A NUMBER OF LOCATIONS DIFFERENT FROM THAT OF THE OTHER OBJECTS; A SECOND MEMORY TO STORE ATTRIBUTES OF EACH OBJECT; A FIRST COMMAND MEANS 48 FOR RECEIVING THESE ATTRIBUTES FROM THE SECOND MEMORY, SO AS TO CONTROL THE ACCESS OF THE SAID DATA FROM THE FIRST MEMORY, THIS FIRST COMMAND MEANS BEING LINKED TO THE FIRST AND TO THE SECOND MEMORY; -A BUFFER 50 TO RECEIVE THE SAID DATA SINCE THE FIRST MEMORY, THIS BUFFER BEING CONNECTED TO THE FIRST MEMORY AND TO THE FIRST COMMAND MEANS.

Terminal modifications of polynucleotides

The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides comprising at least one terminal modification.

Inhibitors of nedd8-activating enzyme

Method and apparatus for minimizing redundant uplink allocation information

Wireless data concentrators for aircraft data networks

Embodiments described herein provide for a four-channel Wireless Data Concentrator (WDC) for a data network of an aircraft. One embodiment of a WDC includes a Printed Circuit Board (PCB), and a controller. The controller is electrically coupled to a top surface of the PCB and is proximate to a centerline of the PCB. The WDC further includes four Radio Frequency (RF) transceivers electrically coupled to the top surface of the PCB that are disposed orthogonally to each other around the controller. Each RF transceiver communicates with at least one wireless sensor that measures an environment of the aircraft. The WDC further includes four inverted-F PCB trace antennas fabricated along the top surface of the PCB. Each inverted-F PCB trace antenna is electrically coupled to one of the RF transceivers and is disposed orthogonally to each other around the controller.

Alternative nucleic acid molecules containing reduced uracil content and uses thereof

MOPA laser pumped through the coating

Fluorous triphase and other multiphase systems

A method of reacting a first compound to produce a second compound includes the step of contacting a first non-fluorous phase including the first compound with a first fluorous phase at a first phase interface. The first compound distributes between the first fluorous phase and the first non-fluorous phase. The method further includes the steps of contacting the first fluorous phase with a second non-fluorous phase at a second phase interface and including at least a third compound in the second non-fluorous phase that reacts with the first compound to produce the second compound. The second compound has a distribution coefficient less than the first compound. This method can, for example be used to separate the second compound from unreacted first compound wherein, for example, the first compound is of a fluorous nature and distributes more readily into (or transports more quickly through) the fluorous phase than does the second compound. In general, the fluorous phase serves as a barrier to prevent the two non-fluorous phases from mixing, but molecules that can migrate through the fluorous phase can pass from one side to the other.

Method and System for Implicit User Equipment Identification

1. Technical Result Increase in efficiency of data processing. 2. Essence A method for data related downlink signaling including selectively tailoring the UE ID to create a UE ID value, which is then added to a data field to create a data mask. This data mask is then further processed as the CRC field and transmitted with the data burst to provide CRC-related functions. An alternative embodiment discloses initializing a CRC generator with UE identification prior to CRC generation. This implicity includes the UE ID within the CRC without requiring additional overhead signaling. 3. Field of Application Radiocommunication system.

System and method for protecting certain types of multimedia data transmitted over a communication channel

Aseptic filter vent valve and port for integrity testing

The present disclosure relates to a filter capsule that supports direct integrity testing of an internal filter element. The filter capsule includes a filter housing having an inlet port, an outlet port, a passage running longitudinally between the inlet port and outlet port and holding a filter element, and an aseptic vent assembly. The filter housing also includes an integrity test assembly that can be used as a direct connection for integrity testing hardware, as opposed to upstream of the filter capsule. In one embodiment, the integrity test assembly comprises a body having a bore formed through its interior and a movable plunger within the bore. The plunger includes a handle to move the plunger between a closed position and an open position. Various seals between the plunger and the bore form a fluid tight seal between various portions of the plunger and the bore.

Method and apparatus for identifying and reporting non-operational enhanced uplink signaling channels

Multiple pumped fiber amplifiers for WDM communication systems with adjustment for the amplifier signal gain bandwidth

A WDM communication system utilizes a pump-mediated gain-shaped fiber amplifier having a predetermined nominal signal gain bandwidth and is pumped by a plurality of laser pump sources having different wavelength outputs with their outputs combined to provide a scaled power output of a weighted average of their wavelengths for launching into at least one end of the fiber amplifier. The weighted average of the output wavelengths of the individual sources is varied to produced a modified weighted average that broadens the predetermined nominal signal gain bandwidth. The wavelength weighted average of the combined pump sources may be modified by changing the operation of at least one of the pump laser sources, e.g., by changing the power level or the temperature level of one or more of the individual pump sources or by terminating the operation of one or of the individual pump sources. The amplifier may then be employed in a multiple channel DWDM communication system with broadened signal gain bandwidth permitting the expansion of the number of possible communication channels utilized with the amplifier.

Induction of apoptic or cytotoxic gene expression by adenoviral mediated gene codelivery

COMPOUNDS TO INHIBIT THE MYTHICAL PROGRESSION

La presente invencion se refiere a compuestos y metodos para el tratamiento del cancer. En particular, la invencion proporciona inhibidores potentes de la cinasa Aurora, composiciones farmaceuticas que comprenden los compuestos, y metodos de uso de los compuestos para el tratamiento del cancer.

Optical transmission systems including signal varying devices and methods

An optical system (10) including plural optical processing nodes (14) in optical communication via a plurality of signal varying devices (12). A first signal varying device including an optical fiber (30) configured to produce Raman scattering/gain in a signal wavelength range and a first signal variation profile. A first pump (12) with multiwavelengths output stimulates Raman scattering/gain within the signal wavelength range. A second signal varying device (12) having a second signal variation profile to produce a cumulative signal variation profile that differs from the first an d second signal variation profiles.

Polynucleotides encoding α-galactosidase A for the treatment of Fabry disease

The invention relates to mRNA therapy for the treatment of Fabry disease. mRNAs for use in the invention, when administered in vivo, encode human the α-galactosidase A (GLA), isoforms thereof, functional fragments thereof, and fusion proteins comprising GLA. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of GLA expression and/or activity in subjects. mRNA therapies of the invention further decrease levels of toxic metabolites associated with deficient GLA activity in subjects, namely Gb3 and lyso-Gb3.

System and method for distributed input distributed output wireless communications

A method is described comprising: transmitting a training signal from each antenna of a base station to each of a plurality of client devices, each of the client devices analyzing each training signal to generate channel characterization data, and transmitting the channel characterization data back to the base station; storing the channel characterization data for each of the plurality of client devices; receiving data to be transmitted to each of the client devices; and precoding the data using the channel characterization data associated with each respective client device to generate precoded data signals for each antenna of the base station; and transmitting the precoded data signals through each antenna of the base station to each respective client device.

Method and apparatus for minimizing redundant enhanced uplink allocation requests

【課題】ＷＴＲＵ（無線送受信ユニット）とノードＢとの間で発生する冗長なＥＵ（enhanced uplink:向上したアップリンク）割当てを最小にし、ＥＵ送信失敗の障害分離のための方法を提供する。 【解決手段】ＷＴＲＵ１０２は、ＵＬ ＥＵチャネル１１０を介して、割当て要求を送信する。Ｅ−ＤＣＨ割当てが予め定められた時間期間内に提供されなかった場合、ノードＢは、Ｅ−ＤＣＨ割当て情報を送信することなく、ＤＬ ＥＵシグナリングチャネル１１２を介してＷＴＲＵに確認メッセージを送信する。要求はノードＢにおける待ち行列に入れられ、時間期間が満了後まで又はリソースが利用可能となるまで、ＷＴＲＵは同じ要求を送信するのを止める。 【選択図】図１

Transport format combination selection in a wireless transmit/receive unit

本發明係有關一種使用於一用戶設備的方法與設備，根據至少該用戶設備之一最大傳送功率，決定可用於一專屬頻道的傳送格式組合。根據一剩餘功率，決定可用於一增強專屬頻道的增強上行的傳送格式組合，並且從該可用的傳送格式組合，為該增強專屬頻道選擇一增強上行的傳送格式組合以供該增強專屬頻道傳輸的裝置。

Process gas distribution system and method

A plurality of gas flow control units in cabinets are connected to distribute process gas, on demand, to a plurality of utilization locations known as "tool" locations in a semi-conductor manufacturing plant. Each gas flow control unit is connected to a single tool interface controller over a single communications cable. The status and operational characteristics of the individual units are communicated through the tool interface controller to a supervisory control computer by means of polling. Each flow control cabinet has its own data processor, and can be operated alone. Also, the supervisory computer can be used to operate each cabinet, as well as to monitor operations of the system. Gas demand and other signals are communicated from each tool locations to the control units through a single cable connected to the interface controller, thusreducing the original wiring cost. Changing the communications path to accompany a change of the tool to which a given conduit in one of the cabinets delivers its gas can be done quickly, in software, with a few keystrokes. Mechanical re-wiring is not needed.

Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture, methods for assaying the effect of substances on lineage-specific cell production, and cell compositions produced by these cultures

Methods, including culture media conditions, which provide for in vitro human stem cell division and/or the optimization of human hematopoietic progenitor cell cultures and/or increasing the metabolism or GM-CSF secretion or IL-6 secretion of human stromal cells and/or a method for assaying the effect of a substance or condition on a human hematopoietic cell population, and/or depleting the malignant cell or T-cell and B-cell content of a human hematopoietic cell population are disclosed. The methods rely on culturing human stem cells and/or human hematopoietic progenitor cells and/or human stromal cells in a liquid culture medium which is replaced, preferably perfused, either continuously or periodically, at a rate of 1 ml of medium per ml of culture per about 24 to about 48 hour period, and removing metabolic products and replenishing depleted nutrients while maintaining the culture under physiologically acceptable conditions. Optionally, growth factors are added to the culture medium. The disclosed culture conditions afford improved methods for bone marrow transplantation.

System and method for frequency offsetting of information communicated in mimo-based wireless networks

A communications system includes a multiple-input/multiple-output (MIMO) architecture for high capacity switched mesh networks. The MIMO architecture has a plurality of radio frequency chains. One of the plurality of radio frequency chains is configured to apply a first frequency offset to a base frequency of an output signal to generate a first transmitting fre-quency; and another of the plurality of radio frequency chains being configured to apply a second frequency offset to the base fre-quency to generate a second transmitting frequency. The system uses the carrier frequency offset to lock the clock of the master subsystem to the clock of the slave subsystem, thereby enabling bandwidth expansion to be employed on the MIMO data streams.

High rate production fiber placement system and method

A fiber placement system including a fiber placement station at a first location, the fiber placement station including a tool and a fiber placement assembly configured to construct a reinforcement layup on the tool, the first fiber placement assembly including a compaction roller rotatable about an axis of rotation, the compaction roller at least partially defining a nip, a thermoplastic composite ply extending through the nip and a heating unit positioned to heat the thermoplastic composite ply proximate the nip, and a consolidation station at a consolidation location, the consolidation location being different from the first location, the consolidation station including a consolidation tool and a consolidation system configured to consolidate a reinforcement layup assembly that includes the reinforcement layup.

Dual axis transducer

DUAL AXIS TRANSDUCER Abstract of the Disclosure A dual axis transducer assembly comprises a transducer (20), a yoke (24) which mounts the transducer for oscillating movement about a sub-stantially horizontal axis. A turntable (28) mounts the yoke and hence the transducer for oscillating motion about a vertial axis. Separate motors (10) and (12) supply motion to the transducer and control means (84), (86), (88) are employed to control the operation of the motors.