Minimally invasive implantable neurostimulation system

An implantable medical device (IMD) has a housing enclosing an electronic circuit. The housing includes a first housing portion, a second housing portion and a joint coupling the first housing portion to the second housing portion. A polymer enclosure member surrounds the joint and circumscribes the housing in various embodiments. Other embodiments of an IMD housing are disclosed.

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

An implantable medical device (IMD) has a housing enclosing an electronic circuit. The housing includes a first housing portion, a second housing portion and a joint coupling the first housing portion to the second housing portion. A polymer seal is positioned in the joint in various embodiments. Other embodiments of an IMD housing are disclosed. 1. An implantable medical device , comprising:an electronic circuit;a housing enclosing the electronic circuit and comprising a first housing portion, a second housing portion and a joint coupling the first housing portion to the second housing portion; anda polymer seal positioned in the joint.2. The device of claim 1 , further comprising a polymer enclosure member claim 1 , wherein the polymer enclosure member comprises a protruding structure to facilitate fixation of the medical device.3. The device of claim 1 , further comprising an electrode along an outer surface of one of the first and the second housing portions.4. The device of claim 1 , further comprising:a conductive coil for receiving inductively coupled energy positioned around an exterior surface of the first housing portion and electrically coupled to the electronic circuit; anda polymer enclosure member surrounding the coil.5. The device of claim 4 , further comprising a mandrel positioned around the first housing portion exterior surface claim 4 , the coil positioned around the mandrel.6. The device of claim 1 , further comprising:a conductive coil for receiving inductively coupled energy positioned around an exterior surface of the first housing portion and electrically coupled to the electronic circuit;a polymer enclosure comprising a first polymer enclosure member surrounding the joint and a second polymer enclosure member surrounding the first polymer enclosure member and the coil.7. The device of claim 6 , further comprising a mandrel extending around an exterior surface of the first housing portion claim 6 , the coil positioned around the mandrel.8. ...

INJECTION MOLDED FERRULE FOR COFIRED FEEDTHROUGHS

Feedthrough assemblies and methods of manufacturing feedthrough assemblies are provided. Methods include molding a ferrule comprising titanium using metal injection molding and positioning the ferrule about at least a portion of an insulator, the insulator comprising alumina. Methods also include overmolding a ferrule about at least a portion of an insulator using metal injection molding, the ferrule comprising titanium and the insulator comprising alumina. Sintering densifies the ferrule and provides a hermetic seal between the ferrule and insulator. The insulator may be fired or unfired prior to sintering of the ferrule. 1. A method of manufacturing a feedthrough assembly comprising:overmolding a ferrule about at least a portion of an insulator using metal injection molding, the ferrule comprising titanium and the insulator comprising a high temperature cofired ceramic alumina (HTCC) or a member selected from the group consisting of alumina, toughened alumina, sapphire, silicon nitride, silicon carbide, zirconia, zircon, and combinations thereof; andsintering to densify the ferrule and provide a hermetic seal between the ferrule and insulator.2. The method of claim 1 , wherein the insulator is a fired insulator or an unfired insulator.3. The method of claim 1 , wherein the insulator and ferrule are co-sintered in a single step.4. The method of claim 1 , wherein a metallization layer comprising a refractory metal is positioned between at least a portion of the ferrule and insulator.5. The method of claim 1 , wherein the metal injection molding comprises:injecting a mixture of titanium particles and binding material into a mold for the ferrule to form a green part, wherein the insulator is positioned within at least part of the mold so that the green part is formed about at least a portion of the insulator;removing the green part from the mold; anddebinding the green part to form a brown part.6. The method of claim 5 , wherein the insulator forms part of the ...

BATTERY ENCASEMENT

An encasement for an electrochemical cell and method of making such encasement is discloses. The design of the encasement results in an encasement having an area of high stress located away from the weld zone area of the encasement, where the cover and the case are welded together. 1. A method comprising:forming a case for an electrochemical cell, the case including a case outer surface having a diameter, a case inner surface having a diameter less than the diameter of the case outer surface, a closed end, and an open end, the open end of the case having a lip and a ledge, the lip having a height and a width, the width of the lip extending from the case inner surface to a point between the diameter of the inner and outer case surfaces, the ledge having a surface extending from the lip to the case outer surface; andforming a cover for attaching to the open end of the case, the cover including a cover outer diameter, a groove extending inwardly from a bottom surface of the cover, a flange having a bottom surface and the flange having a width extending from the outer surface of the cover to the outer surface of the groove, the groove having a substantially rectangular section, the rectangular section having an opening for receiving the lip of the case and the bottom surface of the flange formed to abut the surface of the ledge.2. The method of further comprising mating the cover to the case by mating the lip of the case with the groove of the cover and the bottom surface of the flange with the surface of the ledge.3. The method of further comprising applying heat to an area encompassing the mated surfaces of the flange and the ledge to weld the cover and case together.4. The method of wherein the case contains any one of or any combination of an anode claim 1 , a cathode claim 1 , a separator claim 1 , and an electrolyte.5. The method of wherein heat is applied by means of a laser.6. An apparatus comprising:a case for an electrochemical cell, the case including a case ...

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

An implantable medical device (IMD) has a housing enclosing an electronic circuit. The housing includes a first housing portion, a second housing portion and a joint coupling the first housing portion to the second housing portion. A polymer enclosure member surrounds the joint and circumscribes the housing in various embodiments. Other embodiments of an IMD housing are disclosed. 1. An implantable medical device , comprising:an electronic circuit;a housing enclosing the electronic circuit and comprising a first housing portion, a second housing portion and a joint coupling the first housing portion to the second housing portion; anda polymer enclosure member surrounding the joint.2. The device of claim 1 , wherein the polymer enclosure member comprises a protruding structure to facilitate fixation of the medical device.3. The device of claim 1 , further comprising an electrode along an outer surface of one of the first and the second housing portions.4. The device of claim 1 , further comprising:a conductive coil for receiving inductively coupled energy positioned around an exterior surface of the first housing portion and electrically coupled to the electronic circuit; andthe polymer enclosure member surrounding the coil.5. The device of claim 4 , further comprising a mandrel positioned around the first housing portion exterior surface claim 4 , the coil positioned around the mandrel.6. The device of claim 1 , further comprising:a conductive coil for receiving inductively coupled energy positioned around an exterior surface of the first housing portion and electrically coupled to the electronic circuit;the polymer enclosure comprising a first polymer enclosure member surrounding the joint and a second polymer enclosure member surrounding the first polymer enclosure and the coil.7. The device of claim 6 , further comprising a mandrel extending around an exterior surface of the first housing portion claim 6 , the coil positioned around the mandrel.8. The device of ...

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

An implantable medical device (IMD) has a housing enclosing an electronic circuit. The housing includes a first housing portion, a second housing portion and a joint coupling the first housing portion to the second housing portion. A polymer seal is positioned in the joint in various embodiments. Other embodiments of an IMD housing are disclosed. 120-. (canceled)21. An implantable medical device configured to be implanted proximate a tibial nerve of a patient , the implantable medical device comprising:a housing;a lead including a proximal portion for connecting to the housing, and a distal portion, the lead further including an electrode;a pulse generating circuit enclosed in the housing for delivering electrical stimulation pulses via the electrode to the nerve,wherein the housing is configured to be implanted proximate the fascia layer superficial to the tibial nerve, and the lead is configured to be implanted such that at least a portion of the lead is beneath the fascia layer.22. The implantable medical device of claim 21 , wherein the lead includes a distal paddle portion claim 21 , and wherein the lead is configured to be implanted such that at least a portion of the distal paddle portion is beneath the fascia layer.23. The implantable medical device of claim 21 , wherein the lead includes a distal paddle portion claim 21 , and the electrode is positioned on the distal paddle portion.24. The implantable medical device of claim 23 , further comprising a plurality of electrodes on the distal paddle portion of the lead.25. The implantable medical device of claim 21 , wherein the lead is non-removably coupled to the housing claim 21 , such that the implantable medical device is provided as a single manufactured assembly.26. The implantable medical device of claim 21 , wherein the lead is removably coupleable with the housing.27. The implantable medical device of claim 21 , further comprising at least one fixation member coupled to the housing claim 21 , the at ...

Implantable device with optical lead

An implantable active medical device system includes an active medical device and a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light. The distal end portion includes a solid state light source disposed within a light transmissive ring element. The light transmissive ring element forms an exterior segment of the distal end portion. The light transmissive ring element defines at least a portion of a hermetic cavity.

IMPLANTABLE DEVICE WITH OPTICAL LEAD CONNECTOR

An implantable active medical device includes a housing defining a hermetic cavity, a lead connector receptacle extending into the implantable active medical device, and a solid state light source disposed within the hermetic cavity and optically coupled to the lead connector receptacle. 1. An implantable active medical device comprising:a housing defining a hermetic cavity;a lead connector receptacle extending into the implantable active medical device;a solid state light source disposed within the hermetic cavity and optically coupled to the lead connector receptacle.2. The implantable active medical device according to claim 1 , wherein the lead connector receptacle extends into the hermetic cavity.3. The implantable active medical device according to wherein the lead connector receptacle extends into a header element disposed on the hermetic cavity and an optical feedthrough between the header and the hermetic cavity optically couples the solid state light source to the lead connector receptacle.4. The implantable active medical device according to wherein the lead connector receptacle comprises an electrical contact configured to mate with an electrical contact element on a lead connector engaged in the lead connector receptacle.5. The implantable active medical device according to wherein the solid state light source is optically coupled to an optical feedthrough forming a portion of the lead connector receptacle.6. The implantable active medical device according to wherein the optical feedthrough defines a closed end surface of the lead connector receptacle.7. The implantable active medical device according to wherein the lead connector receptacle extends between a first open end and the optical feed through closed end and an electrical contact claim 6 , configured to mate with an electrical contact element on a lead connector engaged in the lead connector receptacle claim 6 , forms a portion of the lead connector receptacle between the first open end and the ...

IMPLANTABLE DEVICE WITH OPTICAL LEAD

An implantable active medical device system includes an active medical device and a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light. The distal end portion includes a solid state light source disposed within a light transmissive ring element. The light transmissive ring element forms an exterior segment of the distal end portion. The light transmissive ring element defines at least a portion of a hermetic cavity. 1. An implantable active medical device system comprising:an active medical device; 'a solid state light source disposed within a light transmissive ring element, the light transmissive ring element forming an exterior segment of the distal end portion, the light transmissive ring element defining at least a portion of a hermetic cavity.', 'a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light, the distal end portion comprising2. The implantable active medical device system according to claim 1 , wherein the light transmissive ring element is hermetically bonded to an electrode ring element and the electrode ring element forming an exterior segment of the distal end portion.3. The implantable active medical device system according to wherein the hermetic cavity is further defined by an end cap hermetically bonded to the electrode ring element or light transmissive ring element.4. The implantable active medical device system according to wherein the hermetic cavity is further defined by an end cap hermetically bonded to the light transmissive ring element.5. The implantable active medical device system according to wherein the lead distal end portion further comprises a plurality of solid state light sources and a plurality of light transmissive ring elements claim 1 , wherein each light transmissive ring element surrounds one of the solid state light sources forming a ...

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes. 120-. (canceled)21. A minimally invasive implantable tibial nerve stimulation device , comprising:an enclosure constructed of at least one of a biocompatible titanium or stainless steel,the enclosure formed as a single tube having a circular cross-section with an overall length of less than about thirty millimeters and a total volume of less than about one cubic centimeter to enable minimally invasive implantation of the enclosure within a body of a patient;a power supply; a pulse generating circuit;', 'a control unit; and', 'memory, the memory including memory-readable instructions that when executed by the control unit cause the pulse generating circuit of the minimally invasive implantable tibial nerve stimulation device to deliver a nerve stimulation therapy to the tibial nerve of the patient,, 'device electronics within the enclosure includingwherein operation of the minimally invasive implantable tibial nerve stimulation device is selectively adjustable via an external magnetic field; and the telemetry module configured to enable communication with at least one external programming device,', 'wherein communication with the device electronics is confirmable; and, 'a telemetry module within the enclosure,'}an insulative outer coating at least partially surrounding the hermetically sealed enclosure and configured to protect the enclosure and to reduce patient discomfort; and a proximal end configured to be connected to an electrically insulated, sealed header located on one end of the enclosure, and', 'a distal end ...

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes. 120-. (canceled)21. An implantable medical device , comprising:a hermetically sealed housing constructed of at least one of a biocompatible titanium or stainless steel andformed as an elongated tube having a circular cross-sectionwith an overall length of less than about thirty millimeters to enable minimally invasive implantation of the housing within a body of a patient;a pulse generating circuit at least partially housed within the hermetically sealed housing;an insulated lead tethered to one end of the hermetically sealed housing by way of an electrically insulated, sealed feedthrough, the insulated lead including:two or more spaced apart electrodes in electrical communication with the pulse generating circuit, the two or more spaced apart electrodes carried near a distal end of the insulated lead and constructed of at least one of a conductive platinum or platinum iridium material,the two or more spaced apart electrodes are configured to be positioned such that at least one electrode is in proximity to a tibial nerve of a patient for the delivery of a neurostimulation therapy to the tibial nerve of the patient as a treatment for symptoms related to an overactive bladder, anda protective, resilient polymer enclosure at least partially surrounding the hermetically sealed housing.22. The implantable medical device of claim 21 , wherein the hermetically sealed housing has a total volume of about one cubic centimeter.23. The implantable medical device of claim 21 , wherein the hermetically sealed housing has a total ...

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes. 120-. (canceled)21. A low profile implantable medical device configured to lay generally flat beneath skin , muscle or other tissue of a patient for delivering neurostimulation therapy to an acupuncture point for treatment of a symptom associated with the acupuncture point , the implantable medical device comprising:a sealed housing formed of a biocompatible metal, the biocompatible metal comprising at least one of a titanium, stainless steel or an alloy thereof,the sealed housing including:a top face;a bottom face; anda continuous sidewall;wherein each of the top face and the bottom face has a linear dimension of less than approximately twenty-seven millimeters in length,wherein the top face and the bottom face are circumscribed by the continuous sidewall defining an internal cavity,wherein the continuous sidewall extends substantially perpendicular to the top face and is rounded to provide a smooth continuous surface without sharp corners or edges, andwherein the sealed housing generally has a flat profile for positioning between tissue layers of a patient;electronic circuitry positioned within the internal cavity of the sealed housing, the electronic circuitry comprising:a pulse generator,a memory, anda controller configured to cause the pulse generator to deliver a therapy output according to a specified stimulation regimen stored in the memory;two or more electrodes electrically coupled to the pulse generator and located on an exterior surface of the sealed housing, the two or more electrodes comprising:a cathode ...

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

A medical device system for delivering a neuromodulation therapy includes a delivery tool for deploying an implantable medical device at a neuromodulation therapy site. The implantable medical device includes a housing, an electronic circuit within the housing, and an electrical lead comprising a lead body extending between a proximal end coupled to the housing and a distal end extending away from the housing and at least one electrode carried by the lead body. The delivery tool includes a first cavity for receiving the housing and a second cavity for receiving the lead. The first cavity and the second cavity are in direct communication for receiving and deploying the housing and the lead coupled to the housing concomitantly as a single unit. 117-. (canceled)18. A system for providing a tibial nerve stimulation therapy to a patient , the system comprising: a first end;', 'a second end;', circuitry for creating an electrical pulse suitable for stimulating a nerve;', 'a control unit;', 'a telemetry module; and', 'an antenna associated with the telemetry module, the antenna and telemetry module configured to enable communication with at least one external device,', 'wherein the electronic circuitry is located at the first end of the implantable tibial nerve stimulation device; and, 'electronic circuitry for controlling operation of the implantable tibial nerve stimulation device, the electronic circuitry including, 'a plurality of electrodes located at the second end of the implantable tibial nerve stimulation device, the plurality of electrodes in communication with the circuitry for creating an electrical pulse and configured for delivering the tibial nerve stimulation therapy to the patient,', 'wherein the implantable tibial nerve stimulation device is configured to be implanted in a region of a medial malleolus of the patient, and', 'wherein the implantable tibial nerve stimulation device is configured to deliver the tibial nerve stimulation therapy to a tibial ...

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes. 120-. (canceled)21. A low profile implantable medical device configured to lay generally flat beneath skin , muscle or other tissue of a patient for delivering neurostimulation therapy to an acupuncture point for treatment of a symptom associated with the acupuncture point , the implantable medical device comprising: a top face;', 'a bottom face; and', 'a continuous sidewall;, 'a hermetically sealed housing formed of a biocompatible metal, the biocompatible metal comprising at least one of a titanium, stainless steel or an alloy thereof, the hermetically sealed housing includingwherein each of the top face and the bottom face has a linear dimension of less than approximately twenty-seven millimeters in length,wherein the top face and the bottom face are circumscribed by the continuous sidewall defining an internal cavity,wherein the continuous sidewall extends substantially perpendicular to the top face and is rounded to provide a smooth continuous surface without sharp corners or edges, andwherein the hermetically sealed housing generally has a flat profile for positioning between tissue layers of a patient;electronic circuitry positioned within the internal cavity of the hermetically sealed housing, electronic circuitry comprising:a pulse generator,a memory, anda controller configured to cause the pulse generator to deliver a therapy output according to a specified stimulation regimen stored in the memory; the stimulating cathode comprising: an insulator; and an electrically conductive electrode extending through the ...

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

An implantable medical device (IMD) has a housing enclosing an electronic circuit. The housing includes a first housing portion, a second housing portion and a joint coupling the first housing portion to the second housing portion. A polymer seal is positioned in the joint in various embodiments. Other embodiments of an IMD housing are disclosed. 120-. (canceled)21. An implantable neural stimulation device for providing patient monitoring and/or delivering electrical stimulation therapy to a targeted neural site , the implantable neural stimulation device comprising:a housing comprising: a top face; and', 'a sidewall extending substantially perpendicular to and circumscribing the top face, the sidewall being rounded to provide a smooth continuous surface without sharp corners or edges; and, 'a first housing portion, comprising a bottom face; and', 'a flange circumscribing the bottom face and providing a flat surface sealable to the first housing portion to define a sealed internal cavity within the housing;', 'wherein the housing generally has a shape and profile adapted for implantation at a particular implant site, and', 'wherein at least one side of at least one of the first housing portion or the second housing portion is formed from a ceramic material;, 'a second housing portion, comprisingelectronic circuitry mounted on an inner surface of the ceramic material and positioned within the internal cavity of the housing, the electronic circuitry comprising:a coil configured to at least one of receive inductively transmitted power to power the electronic circuitry or enable telemetry communications,a telemetry module configured to establish a bidirectional wireless telemetry link between the electronic circuitry and at least one external device via radiofrequency telemetry,a pulse generator, andat least one feedthrough extending through a layer of the ceramic material along an external surface of the housing;at least one electrode electrically coupled to the ...

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

A medical device system for delivering a neuromodulation therapy includes a delivery tool for deploying an implantable medical device at a neuromodulation therapy site. The implantable medical device includes a housing, an electronic circuit within the housing, and an electrical lead comprising a lead body extending between a proximal end coupled to the housing and a distal end extending away from the housing and at least one electrode carried by the lead body. The delivery tool includes a first cavity for receiving the housing and a second cavity for receiving the lead. The first cavity and the second cavity are in direct communication for receiving and deploying the housing and the lead coupled to the housing concomitantly as a single unit. 117-. (canceled)18. A system for providing a tibial nerve stimulation therapy to a patient , the system comprising: a first end;', 'a second end;', a control unit;', 'circuitry for creating an electrical pulse suitable for stimulating a nerve as part of the tibial nerve stimulation therapy;', 'a power receiving element;', 'a power regulator coupled to the power receiving element; and, 'electronic circuitry for controlling operation of the implantable tibial nerve stimulation device, the electronic circuitry including, 'a plurality of electrodes coupled to the circuitry for creating an electrical pulse, and configured for delivering the tibial nerve stimulation therapy to the patient,, 'an implantable tibial nerve stimulation device for treatment of one or more symptoms associated with an overactive bladder, the implantable tibial nerve stimulation device comprisingwherein the implantable tibial nerve stimulation device is configured to be implanted in a region of a medial malleolus of the patient, andwherein the implantable tibial nerve stimulation device is further configured to deliver the tibial nerve stimulation therapy to a tibial nerve of the patient; and a power supply;', 'a controller;', 'a power transfer control module ...

MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM

A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes. 120-. (canceled)21. A minimally invasive implantable tibial nerve stimulation device having a reduced power requirement duty cycle , comprising:a hermetically sealed enclosure configured to house a pulse generating circuit,the hermetically sealed enclosure constructed of at least one of a biocompatible titanium or stainless steel and formed as an elongated tube having a circular cross-section with an overall length of less than about thirty millimeters to enable minimally invasive implantation of the hermetically sealed enclosure at an implant site within a body of a patient; the lead including two or more spaced apart electrodes in electrical communication with the pulse generating circuit carried near a distal end of the lead,', 'the lead configured to be positioned such that at least one of the two or more spaced apart electrodes is in proximity to a tibial nerve of a patient for the delivery of a neurostimulation therapy to the tibial nerve of the patient as a treatment for symptoms related to an overactive bladder;, 'a lead tethered to one end of the hermetically sealed enclosure by way of an electrically insulated, sealed header,'}an insulative outer coating at least partially surrounding the hermetically sealed housing configured to protect the enclosure and to reduce patient discomfort; andone or more fixation elements operably coupled to the insulative outer coating, the one or more fixation elements formed as a tab defining an aperture through which at least one of a suture or fixation device can be threaded to ...

Tissue engineered vascular grafts

The disclosure relates to systems and methods for tissue engineered grafts. The systems and methods can be used to make tissue engineered vascular grafts. The systems and methods use bioink deposited on a material having specified properties and matured under specified conditions to create the tissue engineered grafts having biomechanical properties tailored to a particular tissue.

TISSUE ENGINEERED SYNTHETIC SUPPORT STRUCTURE

Systems and methods for tissue engineered synthetic support structures, such as grafts and patches are provided. The systems and methods can be used to make tissue engineered planar sheathes or meshes that can be fashioned into substantially planar or non-planar 3D tissue/organ structures adaptable to structure and organs within a human or mammalian body. The systems and methods can use bioink deposited on a material having specified properties and matured under specified conditions to create the tissue engineered planar sheathes or meshes having biomechanical and biological properties tailored to a particular tissue. 1. A method for forming a tissue engineered substantially planar sheet , comprising the steps of:positioning a substantially planar mesh having a plurality of stabilization anchors, onto a substrate and filling a void space in the substantially planar mesh fully or partially with a bioink to form the substantially planar sheet; andmaturing the substantially planar sheet in a bioreactor.2. The method of claim 1 , wherein the stabilization anchor is a hook claim 1 , loop claim 1 , or latch.3. The method of claim 1 , wherein the bioink is placed on the substantially planar mesh by 3D printing claim 1 , dip casting claim 1 , or slot casting.4. The method of claim 1 , wherein the substantially planar mesh is placed on a substrate and a controllable moving syringe dispensing system deposits the bioink.5. The method of claim 1 , where the substantially planar mesh is a weave claim 1 , knit claim 1 , braid claim 1 , non-woven textile claim 1 , or laser cut metal.6. The method of claim 1 , wherein the substantially planar mesh is constructed from a fast-degrading polymer.7. The method of claim 1 , wherein the substantially planar mesh comprises one or more antibiotics or antibiotic agents.8. The method of claim 7 , wherein the antibiotic is minocycline and rifampin and the substantially planar sheet delivers the antibiotic into local tissue for at least 1 day ...

Ceramic components for brazed feedthroughs used in implantable medical devices

A feedthrough assembly, as well as a method of forming a feedthrough assembly, including a metallic ferrule, and a biocompatible, non-conductive, high-temperature, co-fired insulator engaged with the metallic ferrule at an interface between the ferrule and the insulator. The insulator includes a first surface at the interface and a second surface internal to the insulator. At least one conductive member may be disposed at the second surface, wherein at least the first surface of the insulator is devoid of surface cracks greater than 30 μm. The first surface of the insulator may also be devoid of a surface roughness greater than 0.5 μm.

Implantable device with optical lead connector

An implantable active medical device includes a housing defining a hermetic cavity, a lead connector receptacle extending into the implantable active medical device, and a solid state light source disposed within the hermetic cavity and optically coupled to the lead connector receptacle.

Minimally invasive implantable neurostimulation system

A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Minimally invasive implantable neurostimulation system

A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Minimally invasive implantable neurostimulation system

A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Sensor-guided robotic surgery

A surgical robotic system includes a robotic arm having a surgical instrument. The surgical robotic system also includes a surgeon console including a pair of hand controllers for controlling the robotic arm and the surgical instrument. The system further includes a sensor, which may be 3D printed, disposed on tissue and configured to measure at least one parameter pertaining to the tissue. The system additionally includes a controller configured to receive sensor data from the sensor, the sensor data including the at least one parameter and control at least one of the robotic arm or the surgical instrument based on the sensor data.

Tissue engineered synthetic support structure

Systems and methods for tissue engineered synthetic support structures, such as grafts and patches are provided. The systems and methods can be used to make tissue engineered planar sheathes or meshes that can be fashioned into substantially planar or non-planar 3D tissue/organ structures adaptable to structure and organs within a human or mammalian body. The systems and methods can use bioink deposited on a material having specified properties and matured under specified conditions to create the tissue engineered planar sheathes or meshes having biomechanical and biological properties tailored to a particular tissue.

Implantabel device with optical lead

An implantable active medical device system includes an active medical device and a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light. The distal end portion includes a solid state light source disposed within a light transmissive ring element. The light transmissive ring element forms an exterior segment of the distal end portion. The light transmissive ring element defines at least a portion of a hermetic cavity.

Optical member

Optical member

The present invention is directed to an implantable medical device. The implantable medical device includes an optical member formed through diffusion bonding. In one embodiment, the optical member includes a window coupled to a ferrule through a joint that does not include gold.