20-09-2012 дата публикации
Номер: US20120237563A1
The subject invention pertains to controlled-release dosage forms of anabaseine compounds, such as 3-(2,4-dimethoxybenzylidene)-anabaseine (also known as DMXBA or GTS-21) or a pharmaceutically acceptable salt thereof, methods of use, and methods for producing controlled-release dosage forms. 1. A controlled-release dosage form , comprising a therapeutically effective amount of an anabaseine compound and a controlled-release agent.2. The controlled-release dosage form of claim 1 , wherein said controlled-release agent is a controlled-release matrix and wherein said anabaseine compound is incorporated into the controlled-release matrix.3. The controlled-release dosage form of claim 1 , wherein said controlled-release matrix comprises a polymer.4. The controlled-release dosage form of claim 3 , wherein said polymer is nonionic.5. The controlled-release dosage form of claim 3 , wherein said polymer is water-soluble.6. The controlled-release dosage form of claim 3 , wherein said polymer is a gel-forming polymer.7. The controlled-release dosage form of claim 3 , wherein said polymer hydrates in an aqueous environment claim 3 , forming a gelatinous (gel) layer on the outer surface of said dosage form claim 3 , which retards wetting and disintegration of the interior of said dosage form claim 3 , and wherein said gel layer swells or expands claim 3 , increasing in thickness claim 3 , as water penetrates into the dosage form and said anabaseine compound diffuses through said gel layer.8. The controlled-release dosage form of claim 1 , wherein said anabaseine compound is water-insoluble and is released from said dosage form primarily through erosion of said dosage form.9. The controlled-release dosage form of claim 7 , wherein said anabaseine compound is water-soluble and is released from said dosage form primarily through diffusion through said gel layer.10. The controlled-release dosage form of claim 3 , wherein said polymer is a cellulose polymer.11. The controlled-release ...
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