Substituted dihydroquinazolines

The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

Substituted 2-phenyl-3(2h)-pyridazinones

The invention relates to substituted 2-Phenyl-3(2H)-Pyridazinones, to a method for the production thereof, and to their use as medicaments for the prophylaxis and/or treatment of diseases in humans and/or animals.

Substituted dihydroquinazolines

The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

Thiazolyl amides and their use as antiviral drugs

The invention relates to the novel compounds of formula (I), to a method for producing the same and to their use as drugs, especially as antiviral drugs.

Phenyl-substituted 1,4-dihydropyridines

Novel phenyl-substituted 1,4-dihydropyridines, prepared by reacting halogenophenyl-aldehydes with β-ketoesters, if appropriate with isolation of the ylidene compounds and enamines. The substances can be employed as active compounds in medicaments, in particular in cerebrally active compositions.

SUBSTITUTED QUINOLONES III

The invention relates to substituted quinolones and to methods for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.

Phenyl-substituted 1,4-dihydropyridines

Novel phenyl-substituted 1,4-dihydropyridines, prepared by reacting halogenophenyl-aldehydes with beta-ketoesters, if appropriate with isolation of the ylidene compounds and enamines. The substances can be employed as active compounds in medicaments, in particular in cerebrally active compositions.

2-(3-Phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses

The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.

New highly selective process for the preparation of enantiomerically pure phenyl-substituted 1,4-dihydropyridine-3,5-dicarboxylic acid derivatives

2-chloro-3-cyano-benzaldehyde

Benzisothiazolyl-substituted aminomethylchromans

Novel, Acyclically Substituted Furopyrimidine Derivatives and Use Thereof

The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

Method for inhibiting the replication of herpes viruses

The invention relates to a method for inhibiting the replication of herpesviruses, to methods for identifying compounds which inhibit the replication of herpesviruses using this method, to compounds having activity against herpesviruses, to methods for their preparation and to their use for producing medicaments for the treatment of herpes infections.

Substituted arylsulfonamides as antiviral agents

The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.

Substituted pyrazolamides and their use

The present invention relates to novel substituted pyrazolamides, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of retroviral diseases, in humans and/or animals.

Substituted quinolones II

The invention relates to substituted quinolones of formula (I) and to methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.

Repinotan kit

The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration of repinotan or its metabolites in body fluids, and also new pharmaceutical compositions containing repinotan or a physiologically acceptable salt of repinotan, and processes for their preparation.

Substituted dihydroquinazolines

The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

Substituted dihydroquinazolines

The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

SUBSTITUTED AMINOFURANONES AND THEIR USE

The present invention relates to novel substituted aminofurans, to methods for their preparation, to their use in the treatment and/or prophylaxis of diseases as well as their use in the manufacture of medical products for the treatment and/or prophylaxis of diseases, in particular retroviral disorders, in humans and/or animals.

POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF

The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders. 112-. (canceled)14. The pharmaceutical composition of claim 13 , whereinn represents the number 1 or 2,{'sup': '1', 'Rrepresents hydrogen or methyl,'}{'sup': '2', 'Rrepresents linear PEG 40 kDa endcapped with a methoxy-group.'}15. The pharmaceutical composition of claim 13 , whereinn represents the number 1 or 2,{'sup': '1', 'Rrepresents hydrogen,'}{'sup': '2', 'Rrepresents linear PEG 40 kDa endcapped with a methoxy-group.'}16. The pharmaceutical composition of claim 13 , wherein the pharmaceutical form for administration by inhalation is selected from the group consisting of a powder inhaler claim 13 , a nebulizer claim 13 , a solution or a spray.17. The pharmaceutical composition of claim 13 , further comprising an active ingredient selected from the group consisting of ACE inhibitors claim 13 , angiotensin receptor antagonists claim 13 , beta-2 receptor agonists claim 13 , phosphodiesterase inhibitors claim 13 , glucocorticoid receptor agonists claim 13 , diuretics claim 13 , or recombinant angiotensin converting enzyme-2 and acetylsalicylic acid (aspirin).18. The pharmaceutical composition of claim 17 , wherein the active ingredient is selected from an ACE inhibitor selected from the group consisting of enalapril claim 17 , quinapril claim 17 , captopril claim 17 , lisinopril claim 17 , ramipril claim 17 , delapril claim 17 , fosinopril claim 17 , perindopril claim 17 , cilazapril claim 17 , imidapril claim 17 , benazepril claim 17 , moexipril claim 17 , spirapril and trandopril claim 17 , an angiotensin receptor antagonist claim 17 , selected from the group consisting of losartan claim 17 , candesartan claim 17 ...

Benzisothiazolyl-substituted aminomethyl chromanes for treating diseases of the central nervous system

The present invention relates to chromans, to processes for their preparation and to their use in medicaments, in particular as agents for treating disorders of the central nervous system.

Acyclically substituted furopyrimidine derivatives and use thereof

The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

SUBSTITUTED ARYLSULFONAMIDES AS ANTIVIRAL AGENTS

The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.

Novel, Cyclically Substituted Furopyrimidine Derivatives and Use Thereof

The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

Substituted quinolones

The invention relates to substituted quinolones and to processes for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.

2-(3-phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses

The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.

Polyethylene glycol based prodrug of adrenomedullin and use thereof

The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.

Phenyl-substituted 1,4-dihydropyridines

Novel phenyl-substituted 1,4-dihydropyridines, prepared by reacting halogenophenyl-aldehydes with beta-ketoesters, if appropriate with isolation of the ylidene compounds and enamines. The substances can be employed as active compounds in medicaments, in particular in cerebrally active compositions.

Bis-(quinolyl)-diamines

The present invention relates to bis-(quinolyl)-diamines of the general formula (I):in which the indicated substituents are as defined in the description.The invention also provides a process for the preparation of the compounds of the formula (I), their use for the preparation of drugs, and drugs containing said compounds.

Substituted quinolones III

The invention relates to substituted quinolones and to methods for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.

Substituted quinolones II

The invention relates to substituted quinolones of formula (I) and to methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.

Benzisothiazolyl-substituted aminomethyl chromanes for treating diseases of the central nervous system

The present invention relates to chromans, to processes for their preparation and to their use in medicaments, in particular as agents for treating disorders of the central nervous system.

Tyrosine based linkers for the releasable connection of peptides

The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.

Polyethylene glycol based prodrug of adrenomedullin and use thereof

The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.

Cyclically substituted furopyrimidine derivatives and use thereof

The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

Repinotan kit

The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration of repinotan or its metabolites in body fluids, and also new pharmaceutical compositions containing repinotan or a physiologically acceptable salt of repinotan, and processes for their preparation.

Repinotan kit

The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration of repinotan or its metabolites in body fluids, and also new pharmaceutical compositions containing repinotan or a physiologically acceptable salt of repinotan, and processes for their preparation.

Use of 5-substituted pyridine and hexahydroquinoline-3 carboxylic acid derivatives for treating diseases of the central nervous system

The invention relates to the use of 5-substituted pyridine- and hexahydroquinoline-3-carboxylic acid derivatives, some of which are known, for the production of medicaments, in particular for the treatment of cerebral disorders.

Substituted 2-phenyl-3(2h)-pyridazinones

The invention relates to substituted 2-phenyl-3(2h)-pyridazinones, to a method for the production thereof, and to their use as medicaments used in the prophylaxis and/or treatment of diseases in humans and/or animals.

PYRAZOLE DERIVATIVES FOR CONTROLLING ARTHROPODS

The present invention relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects and arachnids. 2. The compound according to claim 1 , wherein{'sub': 1', '4', '2', '4', '1', '4', '3', '6', '1', '4, 'L is linear C-Calkanediyl or C-Calkenediyl, each of which may be substituted with one or more groups independently selected from halogen, C-Calkyl and C-Ccycloalkyl, wherein two C-C-alkyl substituents may form a ring together with the carbon atom to which they are bonded; or'}{'sub': 2', 'n', '2', 'm, 'a moiety (CH)—X—(CH)wherein'}n and m are independently 0, 1 or 2 and{'sup': 1', '2', '3, 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'X is selected from a group X, X, Xor X4 as defined in ; and'}{'sup': 1', '2, 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'Y is selected from a group (T) or (T) as defined in ;'}And/or a salt thereof.3. The compound according to claim 1 , wherein{'sub': 1', '4', '2', '4', '1', '4', '3', '6', '1', '4, 'L is linear C-Calkanediyl or C-Calkenediyl, each of which may be substituted with one or more groups independently selected from halogen, C-Calkyl and C-Ccycloalkyl, wherein two C-C-alkyl substituents may form a ring together with the carbon atom to which they are bonded; or'}{'sub': 2', 'n', '2', 'm, 'a moiety (CH)—X—(CH)wherein'}n and m are independently 0, 1 or 2 and{'sup': 1', '2, 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'X is selected from a group Xor Xas defined in ; and'}{'sup': 1', '2, 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'Y is selected from a group (T) or (T) as defined in ;'}And/or a salt thereof.7. The compound according to claim 1 , wherein{'sub': 2', '4', '2', '4', '1', '4, 'L is linear C-Calkanediyl or C-Calkenediyl, each of which may be substituted with one or more groups independently selected from halogen and C-Calkyl;'}And/or a salt thereof.8. The compound according to claim 1 , ...

POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF

The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders. 2. The compound of claim 1 , whereinn represents the number 1 or 2,{'sup': '1', 'Rrepresents hydrogen or methyl,'}{'sup': '2', 'Rrepresents linear PEG 40 kDa endcapped with a methoxy-group.'}3. The compound of claim 1 , wherein thatn represents the number 1 or 2,{'sup': '1', 'Rrepresents hydrogen,'}{'sup': '2', 'Rrepresents linear PEG 40 kDa endcapped with a methoxy-group.'}5. (canceled)6. (canceled)7. A method of treatment and/or prevention of a cardiovascular claim 1 , edematous and/or inflammatory disorders comprising administering to a human or animal an active amount of a compound of .8. A pharmaceutical composition comprising a compound as claimed in in combination with an inert nontoxic pharmaceutically suitable excipient.9. The pharmaceutical composition of claim 8 , further comprising a further active ingredient.10. A method of treatment and/or prevention of a cardiovascular claim 8 , edematous and/or inflammatory disorders comprising administering to a human or animal an active amount of a pharmaceutical composition of .11. The method of claim 10 , wherein the cardiovascular claim 10 , edematous and/or inflammatory disorder is selected from the group consisting of heart failure claim 10 , coronary heart disease claim 10 , ischemic and/or hemorrhagic stroke claim 10 , hypertension claim 10 , pulmonary hypertension claim 10 , peripheral arterial occlusive disease claim 10 , pre-eclampsia claim 10 , chronic obstructive pulmonary disease claim 10 , asthma claim 10 , acute and/or chronic pulmonary edema claim 10 , allergic alveolitis and/or pneumonitis due to inhaled organic dust and particles of fungal claim ...

POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF

The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders. 112-. (canceled)14. The compound of whereinn represents 1 or 2; and{'sup': '1', 'Ris hydrogen or methyl.'} The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.The 52 amino acid peptide hormone adrenomedullin (ADM) is produced in adrenal gland, lung, kidney, heart muscle and other organs. The plasma levels of ADM are in the lower picomolar range. ADM is a member of the calcitonin gene-related peptide (CGRP) family of peptides and as such binds to a heterodimeric G-protein coupled receptor that consists of CRLR and RAMP 2 or 3 (Calcitonin-receptor-like receptor and receptor activity modifying protein 2 or 3). Activation of the ADM receptor leads to intracellular elevation of adenosine 3′,5′-cyclic monophosphate (cAMP) in the receptor-bearing cells. ADM receptors are present on different cell types in almost all organs including endothelial cells. ADM is thought to be metabolized by neutral endopeptidase and is predominantly cleared in the lung where ADM-receptors are highly expressed [for review see Gibbons C., Dackor R., Dunworth W., Fritz-Six K., Caron K. M., 21(4), 783-796 (2007)].Experimental data from the literature suggest that ADM is involved in a variety of functional roles that include, among others, blood pressure regulation, bronchodilatation, renal function, hormone secretion, cell growth, differentiation, ...

SUBSTITUTED BIPIPERIDINYL DERIVATIVES

The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies. 2. The compound of the formula (I) according to in which{'img': {'@id': 'CUSTOM-CHARACTER-00014', '@he': '2.46mm', '@wi': '4.57mm', '@file': 'US20160318866A1-20161103-P00001.TIF', '@alt': 'custom-character', '@img-content': 'character', '@img-format': 'tif'}, 'represents a single bond,'}{'sup': 1', '6', '7', '8', '9', '10, 'sub': 3', '4', '3, 'claim-text': [{'sub': 1', '3, 'where oxetanyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of 3-hydroxy and 3-C-C-alkyl,'}, 'and', 'where', {'sup': '6', 'Ris selected from the group consisting of hydrogen, methyl and ethyl,'}, {'sup': '7', 'Ris selected from the group consisting of hydrogen, methyl and ethyl,'}, 'or', {'sup': 6', '7, 'Rand Rtogether with the carbon atom to which they are attached form a cyclopropyl ring or cyclobutyl ring,'}, {'sup': 8', '13', '14, 'sub': 1', '3', '1', '3', '1', '3', '1', '3', '2, 'claim-text': [{'sub': 1', '2', '2, 'where phenoxy and pyrazolyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of C-C-alkyl and C1-C-alkoxy,'}, {'sub': 1', '2, 'where oxetanyl may be substituted by 1 or 2 substituents independently of ...

Substituted pyrazolamides and their use

Die vorliegende Erfindung betrifft neue substituierte Pyrazolamide, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere von retroviralen Erkrankungen, bei Menschen und/oder Tieren. The present invention relates to novel substituted pyrazolamides, processes for their preparation, their use for the treatment and / or prophylaxis of diseases and their use for the preparation of medicaments for the treatment and / or prophylaxis of diseases, in particular of retroviral diseases, in humans and / or animals ,

Amino-methyl substituted 2,3-Dihydropyrano (2,3-b) pyridines, process for their preparation and their use in medicines

Aminomethyl-substituierte 2,3-Dihydropyrano[2,3-b]pyridine können durch Alkylierung von entsprechenden Aminen hergestellt werden. Die neuen Aminomethylsubstituierten Dihydropyrano[2,3-b]pyridine können als Wirkstoffe in Arzneimitteln, insbesondere zur Behandlung von Erkrankungen des Zentralnervensystems eingesetzt werden. Aminomethyl-substituted 2,3-dihydropyrano [2,3-b] pyridines can be prepared by alkylating corresponding amines. The new aminomethyl-substituted dihydropyrano [2,3-b] pyridines can be used as active ingredients in medicinal products, in particular for the treatment of diseases of the central nervous system.

substituted quinolones

Quinolonas substituídas. O presente invento se refere a quinolonas substituidas e a métodos para a sua preparação, bem como ao seu uso para a produção de medicamentos para o tratamento e/ou a profilaxia de doenças, especialmente para uso como agentes antivirais, particularmente contra citomegalovírus. Substituted quinolones. The present invention relates to substituted quinolones and methods for their preparation, as well as their use for the manufacture of medicaments for the treatment and / or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegalovirus.

Substituted dihydroquinazolines

The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

Phenyl-substituted 1,4-dihydropyridines

The invention provides compositions, uses and commercial packages for the treatment of a dementia or depression. The compounds of the invention have the general formula: (see formula I) wherein: R1 and R3 are identical or different and represent: (i) straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by straight-chain or branched alkoxy having up to 6 carbon atoms or hydroxyl, or (ii) cycloalkyl having 3 to 7 carbon atoms; and R2 represents the radical: (see formula II) wherein: R4 and R5 are identical or different and represent a halogen atom, cyano, ethinyl, trifluoromethoxy, methyl, methylthio, trifluoromethyl, straight-chain or branched alkoxy having up to 4 carbon atoms or a hydrogen atom, with the proviso that R4 and R5 are not a hydrogen atom simultaneously; or a physiologically acceptable salt thereof.

Azaheterocyclylmethyl-chromans as agents for the treatment of diseases of the central nervous system

Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyanophenyl)-1,4-dyhydro- 2,6-dimethylpyridine-3,5-dicarboxylate, method for its preparation and application in medicamentous forms containing it and intermediate compounds for its preparation

The invention relates to a new compoundrac-isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyanophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate, to its pureenantiomers, to a method for their preparation and application asmedicaments suitable for the treatment of cerebral and neuronaldiseases, as well as to a new intermediate compound for theirpreparation.8 claims

Thiochromenones used to combat painful conditions and neurodegenerative diseases

The invention relates to thiochromenones, to methods for the production thereof, and to the use of the same for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of painful conditions and/or neurodegenerative diseases.

Substituted quinolones iii

Die Erfindung betrifft substituierte Chinolone und Verfahren zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere zur Verwendung als antivirale Mittel, insbesondere gegen Cytomegaloviren.

Cyklohezandienderivat

2-aminomethyl-chromans

2-Aminomethyl-chromans A b s t r a c t Aminomethyl-chromans are obtained by alkylation of correspondingly substituted amines or by reductive amination of correspondingly substituted aldehydes. The aminomethyl-chromans can be used as active compounds in medicaments, in particular for the treatment of diseases of the central nervous system. Le A 28 659 -US

Substituted imidazo pyrimidine ep3 antagonists

The invention relates to substituted imidazo pyrimidine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders. These compounds are EP3 antagonists.

Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyano-phenyl) 1,4-dihydro-2,6-dimethyl-piridine-3,5-dicarboxylate

DIHYDROQUINAZOLINS REPLACED WITH ANTIVIRAL PROPERTIES

1.- Compuesto de fórmula en la que Ar representa arilo, puediendo estar el arilo sustituido con 1 a 3 sustituyentes, seleccionándose los sustituyentes independientemente entre sí del grupo compuesto por alquilo, alcoxi, formilo, carboxilo, alquilcarbonilo, alcoxicarbonilo, trifluorometilo, halógeno, ciano, hidroxi, amino, alquilamino, aminocarbonilo y nitro, pudiendo estar el alquilo sustituido con 1 a 3 sustituyentes, seleccionándose los sustituyentes independientemente entre sí del grupo compuesto por halógeno, amino, alquilamino, hidroxi y arilo, o dos de los sustituyentes del arilo, junto con los átomos de carbono a los que están unidos, forman un 1,3-dioxolano, un anillo de ciclopentano o un anillo de ciclohexano, y un tercer sustituyente eventualmente presente se selecciona independientemente de los grupos citados, R1 representa hidrógeno, amino, alquilo, alcoxi, alquilamino, alquiltio, ciano, halógeno, nitro o trifluorometilo, R2 representa hidrógeno, alquilo, alcoxi, alquiltio, ciano, halógeno, nitro o trifluorometilo, R3 representa amino, alquilo, alcoxi, alquilamino, alquiltio, ciano, halógeno, nitro, trifluorometilo, alquilsulfonilo o alquilaminosulfonilo o uno de los restos R1, R2 y R3 representa hidrógeno, alquilo, alcoxi, ciano, halógeno, nitro o trifluorometilo y los otros dos, junto con los átomos de carbono a los que están unidos, forman un 1,3-dioxolano, un anillo de ciclopentano o un anillo de ciclohexano, R4 representa hidrógeno o alquilo, R5 representa hidrógeno o alquilo o los restos R4 y R5 en el anillo de piperazina están unidos a átomos de carbono exactamente opuestos y forman un puente metileno sustituido eventualmente con 1 a 2 grupos metilo, R6 representa alquilo, alcoxi, alquiltio, formilo, carboxilo, aminocarbonilo, alquilcarbonilo, alcoxicarbonilo, trifluorometilo, halógeno, ciano, hidroxi o nitro, R7 representa hidrógeno, alquilo, alcoxi, alquiltio, formilo, carboxilo, alquilcarbonilo, alcoxicarbonilo, trifluorometilo, halógeno, ciano ...

Secondary 1,3-thiazole-5-yl sulfonamide derivatives and their use as antiviral agents

Substituted dihydrochinazolines having antiviral properties

Pyrrolidine compounds and process of preparing

This invention relates to benzolididene compounds of the formula ##STR1## in which R 2 represents the radical ##STR2## in which R 4 and R 5 are identical or different and denote halogen, cyano, ethinyl, trifluoromethoxy, methylthio, nitro, trifluoromethyl or straight-chain or branched alkyl, alkenyl, alkinyl or alkoxy having up to 4 carbon atoms, and one of the substituents optionally represents hydrogen, or a salt thereof.

Specific monoclonal and polyclonal antibodies to repinotan and its ring-open form

Die Erfindung betrifft monoklonale und polyklonale Antikörper, die Repinotan und dessen ringoffene Form spezifisch erkennen, deren Herstellung und Verwendung zur Bestimmung von Repinotan und dessen ringoffene Form in Körperflüssigkeiten sowie die diese Antikörper produzierenden Hybridomazellen.

Isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1, 4-dihydro-2,6-dimethyl-pyridine-3,5-dica rboxylate

The present invention relates to the new compound rac-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)1,4 -dihydro-2,6-dimethylpyridine-3,5-dicarboxylate and its pure enantiomers, processes for their preparation and their use as medicaments, in particular for the treatment of cerebral and neuronal disorders, and a new intermediate for their preparation.

Novel, acyclically substitued furopyrimidine derivatives and use thereof

The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

Method for inhibiting replication of herpes viruses

Die Erfindung betrifft eine Methode zur Inhibition der Replikation von Herpesviren, Verfahren zum Identifizieren von Verbindungen, welche die Replikation von Herpesviren mit dieser Methode inhibieren, Verbindungen mit Aktivität gegen Herpesviren, Verfahren zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung von Herpes-Infektionen. The invention relates to a method for inhibiting the replication of herpes viruses, a method for identifying compounds which inhibit the replication of herpes viruses with this method, compounds with activity against herpes viruses, methods for their preparation and their use for the preparation of medicaments for the treatment of herpes viruses. infections.

TRIAZASPIRODECANON-METILCROMANOS, PROCEDURE FOR ITS MANUFACTURE AND MEDICINAL PRODUCT CONTAINING THEM.

Novel azaheterocyclylmethyl-chromans

Azaheterocyclylmethylchromans are prepared by reaction of appropriate methylchromans with appropriate azaheterocycles, optionally with subsequent variation of the substituents. The azaheterocyclymethylchromans can be employed as active compounds in medicaments, in particular for the treatment of disorders of the central nervous system.

Application of 1,4-dihydropyridino-3,5-dicarboxylic esters as drugs as well as novel active substances and drugs

Cyclohexadiene derivatives

Polyethylene glycol based prodrug of adrenomedullin and use thereof

Provided is a polyethylene glycol (PEG) based prodrug of adrenomedullin of formula (I), where the variables are as defined in the specification. An exemplified prodrug is O-{ [(3S)-3-Amino-4-({ (2R)-1-amino-3-[(2,5-dioxo-1-{ 3-oxo-3-[(2-{ w-methoxy-poly-oxyethylen[40kDa]} ethyl)amino]propyl} pyrrolidin-3-yl)sulfanyl]-1-oxopropan-2-yl} amino )-4-oxobutyl] carbamoyl} -L-tyrosyl-adrenomedullin(2-52). Further provided are processes for its preparation and its use in the treatment of cardiovascular, edematous and/or inflammatory disorders.

Substituted n-benzyl-n-phenylbenzenesulphonamides for treating viral infections

The invention relates to substituted N-benzyl-N-phenylbenzene-sulphonamides and methods for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against hepatitis C viruses.

Polyethylene glycol based prodrug of adrenomedullin and use thereof

The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.

Benzisothiazolyl-substituted aminomethylchromans

The benzisothiazolyl-substituted aminomethylchromans are prepared either by substituting the corresponding unsubstituted aminomethylchromans on the amine nitrogen or reacting the corresponding benzisothiazolylalkylamines with appropriate activated methylchromans or reacting the amine nitrogen of aminomethylchroman first with an appropriately substituted alkine and then hydrogenating. The benzisothiazolyl-substituted aminomethylchromans can be used as active compounds in medicaments, in particular in medicaments for the treatment of disorders of the central nervous system.

Use of n-substituted phenothiazines

The invention concerns the use of N-substituted phenothiazines for producing drugs for treating cerebral disorders. The invention also concerns novel active substances prepared by reacting phenothiazine with the appropriate acids, esters or amides or by reacting phenothiazine carboxylic acid halides with amines. The active substances are in particular suitable for treating dementia, depression and learning and memory disorders caused by old age.

Piperidylmethyl substituted chroman derivatives as agents for the treatment of diseases of the central nervous system

New highly selective process for the preparation of enantiomerically pure phenyl-substituted 1,4- dihydropyridine-3, 5-dicarboxylic acid derivatives

4-Phenyl-3-substituted 1,4-dihydropyridine esters with cerebral activity

4-Phenyl 3-substituted 1,4-dihydropyridine esters are prepared by reacting benzaldehydes with keto esters and enamines, where appropriate with isolation of ylidene intermediates, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols. The 4-phenyl 3-substituted 1,4-dihydropyridine esters can be used as active ingredients in pharmaceuticals for the treatment of the central nervous system, in particular as cerebral therapeutic agents.

Substituted quinolones iii

The invention relates to substituted quinolines, to a method for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially as antiviral agents, especially for controlling cytomegaloviruses.

Process for producing intermediates of phenyl-substituted 1,4-dihydro-pyridine-3,5-dicarboxylic acid derivatives and the intermediate compounds

Substituted aminofuranones and their use

Die vorliegende Erfindung betrifft neue substituierte Aminofuranone, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere von retroviralen Erkrankungen, bei Menschen und/oder Tieren. The present invention relates to novel substituted aminofuranones, processes for their preparation, their use for the treatment and / or prophylaxis of diseases and their use for the preparation of medicaments for the treatment and / or prophylaxis of diseases, in particular retroviral diseases, in humans and / or animals ,

Substituted dihydrochinazolines having antiviral properties

aminobenzimidazoles

Die Erfindung betrifft substituierte Aminobenzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere von Erkrankungen, die durch Retroviren hervorgerufen werden. The invention relates to substituted Aminobenzimidazole, process for their preparation and their use for the treatment and / or prophylaxis of diseases and their use for the preparation of medicaments for the treatment and / or prophylaxis of diseases, in particular diseases caused by retroviruses.

2,3-Cyclically condensed 1,4-dihydropyridines, process for their preparation and their use as medicaments

Substituted derivatives of 4-phenyl 6-amino nicotinic acid, method of obtaining them and therapeutic agents containing such derivatives

Substituted dihydroquinazolines

THE INVENTION RELATES TO SUBSTITUTED DIHYDROQUINAZOLINES AND TO PROCESSES FOR THEIR PREPARATION AND ALSO TO THEIR USE FOR PREPARING MEDICAMENTS FOR THE TREATMENT AND/OR PROPHYLAXIS OF DISEASES, IN PARTICULAR FOR USE AS ANTIVIRAL AGENTS, IN PARTICULAR AGAINST CYTOMEGALO VIRUSES.

Isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1, 4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate

New substituted acyclic furopyrimidine derivatives and their use for the treatment of cardiovascular diseases

Compuesto de la fórmula (I) **Fórmula** en la que A representa O, S o N-R5, en la que R5 significa hidrógeno, alquilo C1-C6, cicloalquilo C3-C7 o cicloalquenilo C4-C7, L representa alcano C1-C7-diilo o alqueno C2-C7-diilo, que pueden estar sustituidos una o dos veces con flúor,o representa un grupo de fórmula *-L1-Q-L2, en la que * significa el punto de unión con el grupo CHR3, L1 significa alcano C1-C5-diilo, que puede estar sustituido con alquilo C1-C4 o alcoxi C1-C4 , L2 significa un enlace o alcano C1-C3-diilo, que puede estar sustituido una o dos veces con flúor,y Q significa O o N-R6, en la que R6 representa hidrógeno, alquilo C1-C6 o cicloalquilo C3-C7, Compound of the formula (I) ** Formula ** in which A represents O, S or N-R5, in which R5 means hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl or C4-C7 cycloalkenyl, L represents alkane C1-C7-diyl or C2-C7-diyl alkene, which may be substituted once or twice with fluorine, or represents a group of formula * -L1-Q-L2, where * means the point of attachment to the group CHR3, L1 means C1-C5-diyl alkane, which may be substituted with C1-C4 alkyl or C1-C4 alkoxy, L2 means a C1-C3-diyl bond or alkane, which may be substituted once or twice with fluorine, and Q means O or N-R6, wherein R6 represents hydrogen, C1-C6 alkyl or C3-C7 cycloalkyl,

SUBSTITUTED DIHYDROQUINAZOLINS

La invención se refiere a dihidroquinazolinas sustituidas y a procedimientos para su preparación así como a su uso para la preparación de medicamentos para el tratamiento y/o la profilaxis de enfermedades, especialmente para el uso como agente antiviral, especialmente contra citomegalovirus.

Substituted arylsulfonamides as antiviral agents

The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses. (see formula I)

Phenylsubstituted 1,4-dihydropyridines, method of their production, their using and medicines which containing these matters

Phenyl-substituted 1,4-dihydropyridines prepared by reacting halophenylaldehydes with beta -keto esters, where appropriate with isolation of the ylidene compounds and enamines. The substances can be used as active ingredients in pharmaceuticals, in particular in compositions with cerebral activity.

Substituted dihydrochinazolines having antiviral properties

TRIAZASPIRODEKANON-METYLKROMANER

SUBSTITUTED ARILSULPHONAMIDS

Arilsulfonamidas, proceso para su preparacion y su utilizacion para la produccion de medicamentos para el tratamiento y/o la profilaxis de enfermedades, especialmente para su utilizacion como agentes antivirales, particularmente contra los citomegalovirus. Reivindicacion 1: Compuesto caracterizado porque responde a la formula (1) donde A representa un grupo de formulas (2) donde * es el sitio de union con el átomo de carbono del anillo piridinilo y es el sitio de union con el átomo de carbono del anillo fenilo, R1 representa hidrogeno, amino o metilcarbonilamino, R2 representa hidrogeno o halogeno, R3 representa hidrogeno, halogeno o ciano, R4 representa hidrogeno, halogeno o ciano, R5 representa hidrogeno, o halogeno, R6 representa hidrogeno, o halogeno, R7 hidrogeno, halogeno o alquilo C1-3, R8 representa hidrogeno, halogeno o alquilo C1-3, o una de sus sales, sus solvatos o los solvatos de sus sales. Arylsulfonamides, process for its preparation and its use for the production of medicines for the treatment and / or prophylaxis of diseases, especially for its use as antiviral agents, particularly against cytomegalovirus. Claim 1: Compound characterized in that it responds to formula (1) wherein A represents a group of formulas (2) where * is the site of union with the carbon atom of the pyridinyl ring and is the site of union with the carbon atom of the Phenyl ring, R1 represents hydrogen, amino or methylcarbonylamino, R2 represents hydrogen or halogen, R3 represents hydrogen, halogen or cyano, R4 represents hydrogen, halogen or cyano, R5 represents hydrogen, or halogen, R6 represents hydrogen, or halogen, R7 hydrogen, halogen or C1-3 alkyl, R8 represents hydrogen, halogen or C1-3 alkyl, or one of its salts, its solvates or the solvates of its salts.

Thiochromenones used to combat painful conditions and neurodegenerative diseases

The invention relates to thiochromenones, to methods for the production thereof, and to the use of the same for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of painful conditions and/or neurodegenerative diseases.

Use of 5-substituted pyridine and hexahydroquinoline-3 carboxylic acid derivatives for treating diseases of the central nervous system

Partially known 5-substituted pyridine and hexahydroquinoline-3 carboxylic acid derivatives are used to prepare medicaments used in particular for treating diseases of the central nervous system.

Thiochromenones used to combat painful conditions and neurodegenerative diseases

The invention relates to thiochromenones, to methods for the production thereof, and to the use of the same for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of painful conditions and/or neurodegenerative diseases.

Novel, acyclically substitued furopyrimidine derivatives and use thereof

The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

2-chloro-3-cyano-benzaldehyde and process for it's preparation

A találmány új vegyületre, a 2-klór-3-ciano-benzaldehidre vonatkozik.A találmány kiterjed a fenti vegyület előállítására oly módon, hogy 2-klór-3-ciano-toluolt katalizátor jelenlétében inert oldószerbenmegfelelő benzál-bromiddá alakítanak, és ezt oldószerben ezüstsójelenlétében aldehiddé alakítják. A találmány szerinti vegyületkiindulási anyagként alkalmazható az izopropil-(2-metoxi-etil)-4-(2-klór-3-ciano-- fenil)-1,4-dihidro-2,6-dimetil-piridin-3,5-dikarboxilátelőállításához. ŕ

Substituted 1,4- dihydropyridine derivative, preparation process, intermediate for the synthesis thereof and composition containing the same

The present invention relates to a substituted 1,4-dihydropyridine derivative, to the process of preparing the same, to an intermediate used in the synthesis thereof and to a composition containing the same, said compound being used as medicine for the treatment of cerebral and neuronal disorders. The invention relates particularly to isopropyl 2-methoxyethyl-4- (2- chloro-3- cyano- phenyl) - 1,4- dihydro- 2,6- dimethylpyridin-3,5 - dicarboxylate, in the form of a racemic or enantiomers mixture, which can be prepared by different ways of synthesis which involve the use of 2-chloro - 3- cyano- benzaldehyde derivativee.

Dihydroquinazolines substituted with antiviral properties

HIGH SELECTIVE METHOD FOR THE PREPARATION OF DERIVATIVES OF PHENYLATED, 3,4-DIHYDROPYRIDINE ACID, 3,4-DIHYDROPYRIDINE-3-DICARBOXYL ACID

Phenyl substituted 1,4-dihydropyridines

Use of substituted 4-phenyl-6-amino-nicotinic acid derivatives as medicaments

Isopropyl-(2-methoxyethyl)-4-(2-chloro-3-cyanophenyl)-1,4- dihydro-2,6-dimethylpyridine-3,5-dicarboxylate, its preparation method, pharmaceutical preparation, use and 2-chloro-3-cyano-benzaldehyde as intermediate

Je opísaný rac-izopropyl-(2-metoxyetyl)-4-(2-chlór-3-kyano- fenyl)-1,4-dihydro-2,6-dimetylpyridín-3,5-di-karboxylát vzorca (I) a jeho čisté enantioméry, spôsob jeho výroby, farmaceutický prostriedok s jeho obsahom a jeho použitie na výrobu liečiva na potláčanie cerebrálnych a neuronálnych ochorení, ako i medziprodukt na výrobu tejto zlúčeniny, ktorým je 2-chlór-3-kyano-benzaldehyd vzorca (II).ŕ Disclosed is rac-isopropyl (2-methoxyethyl) -4- (2-chloro-3-cyanophenyl) -1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate of formula (I) and its pure enantiomers, a process for its preparation, a pharmaceutical composition comprising it, and its use for the manufacture of a medicament for controlling cerebral and neuronal diseases, as well as an intermediate for the manufacture of this compound, which is 2-chloro-3-cyanobenzaldehyde of formula (II). à

2,2'-bridged bis-2,4-diaminoquinazolines

The present invention relates to 2,2'-bridged bis-2,4-diaminoquinazolines of the general formula (I): ##STR1## in which the indicated substituents are as defined in the description. The invention also provides processes for the preparation of the compounds of the formula (I), their use for the preparation of drugs, and drugs containing said compounds.

REPINOTAN COFFEE MUG

tyrosine-based linkers for reversible peptide binding

resumo da patente de invenção para: "ligadores à base de tirosina para a ligação reversível de peptídeos". a invenção diz respeito a novos ligadores à base de tirosina que permitem a ligação reversível de peptídeos ou de proteínas a outras entidades moleculares, v.g., polietileno-glicol, a processos para a sua preparação e a sua utilização para a preparação de medicamentos para o tratamento e/ou para a profilaxia de doenças.

Isopropyl- (2-methoxyethyl) -4- (2-chloro-3-cyanophenyl) -1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

SUBSTITUTED DIHYDROCHINAZOLINES WITH ANTIVIRAL PROPERTIES

Polyethylene glycol based prodrug of adrenomedullin and use thereof

The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.

2,3-bridged 1,4-dihydropyridines, and their use as medicaments

The present invention relates to new 2,3-bridged 1,4-dihydropyridines of the general formula (I), in which R, R1, R2, D and E have the meaning given in the description, processes for their preparation and their use as medicaments, preferably for treatment of the central nervous system.

Biphenyl substituted spirotetronic acids and their use for the treatment of retroviral diseases

The present invention relates to novel substituted spirotetronic acids (I) in which R1 and R2, together with the carbon atom to which they are bonded, form a group of the formula (1), (2), (3) or (4), where * is the carbon atom to which R1 and R2 are bonded, to processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular of retroviral disorders, in people and/or animals.

2-aminomethyl-chromans effective in the treatment of psychoses and depression

Diseases characterized by disturbances of the serotoninergic system, psychoses and depression are treated by administration of an aminomethyl-chroman of the formula ##STR1##

Dioxo-thiopyrano-pyridine carboxylic acid derivatives and their use as medicaments

PIPERIDYLMETHYL-SUBSTITUTED CHROMANDER DERIVATIVES

Novel azaheterocyclylmethyl-chromans.

Use of bisquinoline compounds in the treatment of cerebral disorders

The present invention relates to the use of bisquinolines of the general formula ##STR1## in which the substituents mentioned have the meanings given in the description. The invention furthermore relates to new bisquinolines of the general formula (I), to a process for the preparation of the known and the new bisquinolines, to the use of the new bisquinolines as medicaments, to their use for the preparation of medicaments, and to medicaments comprising them.

2-Chloro-3-cyanobenzaldehyde and method ta

2-aminomethyl-chromans

Dioxo-thiopyrano-pyridine carboxylic acid derivatives and their use as medicaments

Dioxo-thiopyrano-pyridine carboxylic acid derivatives of formula (I) are produced by reacting corresponding aldehydes with aminocrotonic acid ester and tetrahydrothiopyrane-3-one-1,1 dioxyde and oxidising the products thus obtained. The substances of the invention can be used as active agents in medicaments. They are selective modulators of the calcium-dependent potassium channels of high conductivity.

SUBSTITUTED 2-PHENYL-3 (2H) -PYRIDAZINONE

Phenyl-substituted 1,4-dihydropyridines

【課題】新規なフェニル−置換１，４−ジヒドロピリジン類を提供する。 【解決手段】一般式 ［式中、Ｒ １ 及びＲ ３ は直鎖状もしくは分枝鎖状のアルキル等を示し、Ｒ ２ は１置換又は２置換のフェニル基を示す］のフェニル−置換１，４−ジヒドロピリジン類及びそれらの塩、ならびにそれらの製造法。 【選択図】なし

4-heterocyclophenyl-substituted dihydropyridines

4-Heterocyclophenyl-substituted dihydropyridines A b s t r a c t 4-Heterocyclophenyl-substituted dihydropyridines are prepared either by reacting suitable aldehydes with amino esters and .beta.-keto esters, or preparing the heterocyclic substituents of the 4-phenyl by cyclization of corresponding amidines or hydrazides, or esterifying dihydropyridinecarboxylic acids, which are already substituted by heterocyclic radicals, with corresponding alcohols. The 4-heterocyclophenyl-substituted dihydropyridines can be employed in medicaments, in particular for treatment of diseases of the central nervous system.

Benzisothiazolyl-substituted aminomethyl chromanes

Substituted dihydroquinazolines with antiviral properties

Substituted dihydroquinazolines

The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

Biphenyl substituted spirotetronic acids and their use for the treatment of retroviral disorders

The present invention relates to novel substituted spirotetronic acids (I) in which R<SUP>1</SUP> and R<SUP>2</SUP>, together with the carbon atom to which they are bonded, form a group of the formula (1), (2), (3) or (4), where * is the carbon atom to which R<SUP>1</SUP> and R<SUP>2</SUP> are bonded, to processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular of retroviral disorders, in people and/or animals.

2,3-cyclicly condensed 1,4-dihydropyridines, process for preparing the same, drugs containing the same and their use

2,3-Fused 1,4-dihydropyridine-5-carboxylic acid derivs. of formula (I) and their salts are new: R = 6-10C aryl or pyridyl, opt. substd. by 1-5 of CN, halogen, CF3 and 1-6C alkylthio; R1 = H or 1-8C alkyl; R2 = 1-6C alkyl or 3-6C cycloalkyl; D+E = -CO-(CH2)3-, -CO-CH2-CMe2-CH2-, -CO-O-CH2- or -CH2-O-CO-.

Cyclohexadiene derivatives

Use of acyclically substituted furopyrimidine derivatives for treating pulmonary arterial hypertonia

The invention relates to the use of acyclically substituted furopyrimidine derivatives of formula (I) for the treatment and/or prophylaxis of pulmonary arterial hypertonia and other forms of pulmonary hypertonia and to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of pulmonary arterial hypertonia and other forms of pulmonary hypertonia.

Substituted quinolones

Pyrazole derivatives for controlling arthropods

The present invention relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects and arachnids.

2,3-dihydro-pyrano(2,3-b)pyridine derivatives substituted with amino-methyl group, method for producing them and pharmaceutical preparatives containing said compounds