Verfahren zum Ermitteln der relativen Lage eines Gaslecks

Verfahren zum Ermitteln der relativen Lage eines Gaslecks in Bezug auf einen Schnüffellecksucher (10), derein Handstück (44) mit einer Schnüffelsonde mit einem Prüfgaseinlass (12),einen an dem Handstück entfernt von dem Prüfgaseinlass (12) angeordneten Referenzgaseinlass (14),einen Gasanalysator (16) undein Schaltventil (20) aufweist,wobei das Schaltventil (20) zum abwechselnden Verbinden des Prüfgaseinlasses (12) mit dem Gasanalysator (16) und des Referenzgaseinlasses (14) mit dem Gasanalysator (16) in gasleitender Weise ausgebildet ist, sodass entweder das durch den Prüfgaseinlass (12) angesaugte Gas oder das durch den Referenzgaseinlass (14) angesaugte Gas von dem Gasanalysator (16) analysiert wird, mit den Schritten:a) Zuführen von durch den Prüfgaseinlass (12) angesaugtem Gas zu dem Gasanalysator (16),b) Bestimmen der Testgaskonzentration in dem dem Gasanalysator (16) zugeführten Gas,c) Umschalten des Schaltventils (20),d) Zuführen von durch den Referenzgaseinlass (14) angesaugtem ...

Verfahren und Vorrichtung zum automatischen Erstellen einer ausführbaren Sicherheitsfunktion für ein Gerät

Verfahren zum automatischen Erstellen einer ausführbaren Sicherheitsfunktion für ein Gerät, mit:Erfassen (101) von digitalen Parametern, welche eine bestimmte Sicherheitsfunktion spezifizieren;Bestimmen (103) eines ersten Prüfwertes auf der Basis der digitalen Parameter;automatischem Zuordnen (105) einer Anzahl von digitalen Funktionsbausteinen aus einer Mehrzahl von vordefinierten digitalen Funktionsbausteinen zu den erfassten digitalen Parametern, um einen Sicherheitsfunktionsquellcode der bestimmten Sicherheitsfunktion zu erhalten;Kompilieren (107) des Sicherheitsfunktionsquellcodes, um die ausführbare Sicherheitsfunktion zu erhalten;Bestimmen (108) eines zweiten Prüfwertes auf der Basis der ausführbaren Sicherheitsfunktion; undAusgeben (113) der ausführbaren Sicherheitsfunktion falls der erste Prüfwert und das zweite Prüfwert ein Überprüfungskriterium erfüllen.

Lötfreie Verbindung zu Hochfrequenzlitze

Eine elektrische Kontaktbaugruppe 10 ist offenbart, die eine geflochtene Hochfrequenzlitze 14 und einen elektrischer Kontakt 12 aufweist. Der elektrische Kontakt 12 hat einen Kontaktabschnitt 16 und einen Hochfrequenzlitzen-Terminierungsabschnitt 18. Der Kontaktabschnitt16 ist ausgestaltet eine elektrische Verbindung mit einem Gegenkontakt herzustellen. Der Hochfrequenzlitzen-Terminierungsabschnitt 18 weist Einkerbungen 28 auf, welche die geflochtene Hochfrequenzlitze 14 erfassen. Der Hochfrequenzlitzen-Terminierungsabschnitt 14 hat eine Länge, die es dem Hochfrequenzlitzen-Terminierungsabschnitt 14 erlaubt, eine elektrische Verbindung mit jedem Einzelkabel 50 der Hochfrequenzlitze herzustellen.

Endhörner für eine Stromabnehmeranordnung

Eine Stromabnehmeranordnung ist konfiguriert, um elektrische Leistung von einer Oberleitung zu einer Maschine zu übertragen. Die Stromabnehmeranordnung weist einen Stromabnehmerträger auf, der entfernbar mit der Maschine verbunden ist, eine Gelenkanordnung, eine Stromabnehmerschiene und eine Karbon- bzw. Kohlenbürste. Der Stromabnehmerträger weist ein erstes Verbindungselement und ein zweites Verbindungselement auf, welches scharnierartig mit dem ersten Verbindungselement verbunden ist. Das erste Verbindungselement ist mit dem Stromabnehmerträger verbunden. Die Stromabnehmerschiene wird von dem zweiten Verbindungselement der Gelenkanordnung getragen. Die Kohlenbürste wird von der Stromabnehmerschiene entlang einer Längsachse der Stromabnehmerschiene getragen. Die Stromabnehmeranordnung weist weiter ein Endhorn mit einem Brückenteil auf, der mit der Kohlenbürste verbunden ist. Der Brückenteil ist konfiguriert, um die Oberleitung zwischen dem Endhorn und der Kohlenbürste zu transferieren.

System, Verfahren und Vorrichtung zum Verwalten der Nachbehandlungstemperatur

Offenbart werden ein System und Verfahren zum Steuern der Temperatur eines Nachbehandlungssystems, wobei das Verfahren das Interpretieren einer Nachbehandlungsangabetemperatur, das Bestimmen, dass ein Motorkraftstoffversorgungsbedarf null ist, und das Ausrücken des Motors aus einem Getriebe beinhaltet, in Reaktion darauf, dass die Nachbehandlungsangabetemperatur unter einen ersten Schwellenwert fällt, und in Reaktion darauf, dass der Motorkraftstoffversorgungsbedarf null ist, wobei der Motor und das Getriebe einen Teil eines Fahrzeugantriebsstrangs bilden. Alternativ kann das Verfahren das Interpretieren einer Nachbehandlungsangabetemperatur, das Bestimmen, dass ein Motorkraftstoffversorgungsbedarf null ist, und das Durchführen eines Vorgangs mit reduziertem Luftdurchsatz durch den Motor beinhalten, in Reaktion darauf, dass die Nachbehandlungsangabetemperatur unter einen ersten Schwellenwert sinkt, und in Reaktion darauf, dass der Motorkraftstoffversorgungsbedarf null ist.

Method for reducing e.g. hydrocarbon emissions from diesel engine of light duty vehicle during low exhaust gas temperature operation, involves treating released emissions with oxidation catalyst and nitrogen oxide reduction catalyst

The method involves storing hydrocarbon and nitrogen oxide emissions from an internal combustion engine (20) during a low exhaust gas temperature operation in an exhaust gas flowpath (18) upstream of a nitrogen oxide reduction catalyst (16). The stored hydrocarbon and nitrogen oxide emissions are released into the exhaust gas flowpath when the exhaust temperature increases toward effective operating temperature, which is equal to 200 degree Celsius. The released hydrocarbon and nitrogen emissions are treated with an oxidation catalyst and the nitrogen oxide reduction catalyst. The oxidation catalyst is a hydrocarbon storage device catalyst. The nitrogen oxide reduction catalyst is a selective catalytic reduction catalyst. An independent claim is also included for a system for reducing nitrogen oxide and hydrocarbon emissions from an internal combustion engine during a low exhaust gas temperature operation.

Verfahren zur Bestimmung des Wasserstoffanteils in einer Wasserstoff/Erdgasmischung

Die Erfindung betrifft ein Verfahren und einen Sensor zur Bestimmung des Wasserstoffanteils in einer Wasserstoff/Erdgasmischung (102).Dabei ist zunächst eine Bestimmung des Anteils von zumindest einem Erdgasbestandteil mittels zumindest einer IR-Absorptionsmessung (V3) vorgesehen. Nachfolgend wird der Wasserstoffanteil aus dem mindestens einen bestimmten Anteil berechnet (V4).

Sensor zur Erfassung mindestens einer Eigenschaft eines Messgases in einem Messgasraum

Es wird ein Sensor (10) zur Erfassung mindestens einer Eigenschaft eines Messgases in einem Messgasraum, insbesondere zur Erfassung eines Anteils einer Gaskomponente in dem Messgas oder einer Temperatur des Messgases, vorgeschlagen. Der Sensor (10) umfasst ein Sensorelement (20), ein Gehäuse (12) und eine Schutzhülse (42). Das Gehäuse (12) ist zumindest teilweise von der Schutzhülse (42) umgeben und weist eine Längsbohrung (16) auf, in der das Sensorelement (20) angeordnet ist. Der Sensor (10) weist weiterhin einen Kontakthalter (44) und eine Federklammer (46) auf. Der Kontakthalter (44) ist zum Halten des Sensorelements (20) ausgebildet. Die Federklammer (46) ist zum Fixieren des Kontakthalters (44) ausgebildet. Die Federklammer (46) ist zwischen dem Gehäuse (12) und der Schutzhülse (42) derart elastisch verformt angeordnet, dass die Federklammer (46) eine erste Vorspannkraft auf den Kontakthalter (44) ausübt.

Sensor zur Erfassung mindestens einer Eigenschaft eines Messgases in einem Messgasraum

Es wird ein Sensor (10) zur Erfassung mindestens einer Eigenschaft eines Messgases in einem Messgasraum, insbesondere zur Erfassung eines Anteils einer Gaskomponente in dem Messgas oder einer Temperatur des Messgases, vorgeschlagen. Der Sensor (10) umfasst ein Sensorelement (20) und ein Gehäuse (12), wobei das Gehäuse (12) eine Längsbohrung (16) aufweist, in der das Sensorelement (20) angeordnet ist, wobei der Sensor (10) weiterhin einen Kontakthalter (28) und ein Stützelement (30) aufweist, wobei der Kontakthalter (28) derart ausgebildet ist, dass der Kontakthalter (28) von dem Sensorelement (20) in eine vorbestimmte Endposition in dem Gehäuse (12) geführt ist, wobei das Stützelement (30) zum Fixieren des Kontakthalters (28) in der Endposition ausgebildet ist, wobei das Stützelement (30) zum Lagern an einem Kabelbaum (32) ausgebildet ist, wobei das Stützelement (30) und der Kontakthalter (28) miteinander kardanisch verbunden sind.

Automatisierung einer oberleitungsbetriebenen Maschine durch Aufzeichnung und Wiedergabe

Ein System und Verfahren zum automatischen Leiten bzw. Führen eines Geländelastwagens mit einem Stromabnehmer entlang einer Route mit wenigstens einem Abschnitt mit Oberleitungsbetrieb werden beschrieben. Während der Geländelastwagen von einem menschlichen Bediener entlang der Route betrieben wird, werden seine Position und der Zustand des Stromabnehmers an jeder Position aufgezeichnet, um eine aufgezeichnete Sequenz zu erzeugen. Die aufgezeichnete Sequenz wird abgerufen und der Geländelastwagen wird automatisch gesteuert, um sequenziell jede Position und jeden Stromabnehmerzustand an der assoziierten Position abzugleichen.

Einspritz- und Mischsystem für Reduktionsmittel

Ein Einspritz- und Mischsystem (10) für gasförmiges Reduktionsmittel wird hierin beschrieben. Das System weist einen Injektor (20) zum Einspritzen eines gasförmigen Reduktionsmittels in einen Abgasstrom und einen Mischer (30), der an einer Oberfläche (84, 86) des Injektors befestigt ist, auf. Der Injektor weist eine Vielzahl von Öffnungen (28) auf, durch die das gasförmige Reduktionsmittel in einen Abgasstrom eingespritzt wird. Der Mischer weist eine Vielzahl von Fluidumleitungselementen (32) auf.

Verfahren zur Herstellung von Brennstoffen

Es wird ein Verfahren zur Herstellung von Brennstoffen vorgeschlagen, dass sich dadurch auszeichnet, dass auf sich autonom auf dem Meer beweglichen Schwimmkörpern unter Zuhilfenahme natürlicher Energiequellen zunächst eine Elektrolyse des Meerwasser vorgenommen wird, der dabei entstehende Wasserstoff physikalisch oder chemisch gebunden wird, um ihn selbst als Brennstoff zu nutzen oder ihn mittels an sich bekannter chemischer Methoden zu Brennstoffen weiter zu verarbeiten ...

Automatische Stromabnehmersteuerung für ein Minenlastwagenleistungssystem

Das Steuern eines Leistungssystems in einem Minenlastwagen weist auf, Daten, welche eine erwartete Änderung der Eignung des Minenlastwagens für einen Oberleitungsbetrieb anzeigen, zu empfangen und einen Steuerbefehl an einen Betätigungsmechanismus für einen Stromabnehmer ansprechend auf die Daten und vor dem Auftreten der erwarteten Eignungsänderung auszugeben. Ein Minenlastwagen und ein Leistungssystem werden weiter vorgesehen, wobei ein Stromabnehmer mit einem elektrischen Kontaktelement zwischen einer ersten Konfiguration in Kontakt mit einer oben liegenden Oberleitung und einer Ruhekonfiguration eingestellt wird, und zwar ansprechend auf Daten, welche die erwartete Eignungsänderung anzeigen.

Gassensor zur Bestimmung einer physikalischen Eigenschaft eines Messgases

Gassensor zur Bestimmung einer physikalischen Eigenschaft eines Messgases, insbesondere der Temperatur des Messgases oder der Konzentration eine Gaskomponente des Messgases, mit einem Gehäuse (10), mit einem im Gehäuse (10) festgelegten Sensorelement (11), das mittels einer das Sensorelement (11) umschließenden, zwischen einem unteren und oberen Keramikformteil (13, 14) axial verpressten Dichtung (12) an der Gehäuseinnenwand (101) radial abgestützt ist, mit einem messgasseitigen Endabschnitt (111) aus dem Gehäuse (10) vorsteht und auf einem davon abgekehrten, anschlussseitigen Endabschnitt (112) mindestens eine Kontaktfläche (15, 16) trägt, und mit einer auf den anschlussseitigen Endabschnitt (112) aufgesetzten Kontaktierungsbaugruppe (17), die eine elektrische Verbindung der mindestens einen Kontaktfläche (15, 16) zu einem Leiter (18, 19) einer vom Sensorelement (11) wegführenden Anschlussleitung (20) herstellt, wobei der anschlussseitige Endabschnitt (112) des Sensorelements (11) mit ...

Systeme und Verfahren zum Steuern einer Reduktionsmittelzufuhr in einen Abgasstrom

Es werden Verfahren und Systeme offenbart zum Ermitteln einer Zufuhrrate zur unmittelbaren Einleitung eines Reduktionsmittelgases in einen Abgasstrom, um ein NOx-Emissionsziel zu erreichen und zum Steuern einer Reduktionsmitteleinleitungseinrichtung, um das Reduktionsmittelgas mit der ermittelten Zufuhrrate in den Abgasstrom eintreten zu lassen.

Verfahren zur Reinigung von marinem Kollagen

Verfahren zur Reinigung von marinem Kollagen, umfassend die Schritte: Einstellen des Feuchtigkeitsgehalts eines in einem sauren Medium ausgefällten Kollagenpräzipitats auf 95 bis 70 Gew.-%, Suspendieren des Kollagens in einer wässrigen H2O2-Lösung Solubilisieren des Kollagens durch Einstellen des pH der Kollagensuspension auf einen Wert von zwischen 11 bis 13; Ausfällen des Kollagens mit einem organischen, mit Wasser mischbaren Lösungsmittel, Abfiltrieren des Kollagens, Einstellen des Feuchtigkeitsgehalts des ausgefällten Kollagens auf 95 bis 70 Gew.-%, Resuspendieren des Kollagens in einer wässrigen H2O2-Lösung, und Einstellen des pH der resultierenden Kollagenlösung auf einen Wert von zwischen 5 bis 7.

Verfahren und Vorrichtung zum automatischen Erstellen einer ausführbaren Sicherheitsfunktion für ein Gerät

Die Erfindung betriff ein Verfahren zum automatischen Erstellen einer ausführbaren Sicherheitsfunktion für ein Gerät, mit Erfassen (101) von digitalen Parametern, welche eine bestimmte Sicherheitsfunktion spezifizieren, Bestimmen (103) eines ersten Prüfwertes auf der Basis der digitalen Parameter, automatischem Zuordnen (105) einer Anzahl von digitalen Funktionsbausteinen aus einer Mehrzahl von vordefinierten digitalen Funktionsbausteinen zu den erfassten digitalen Parametern, um einen Sicherheitsfunktionsquellcode der bestimmten Sicherheitsfunktion zu erhalten, Kompilieren (107) des Sicherheitsfunktionsquellcodes, um die ausführbare Sicherheitsfunktion zu erhalten, Bestimmen (108) eines zweiten Prüfwertes auf der Basis der ausführbaren Sicherheitsfunktion, und Ausgeben (113) der ausführbaren Sicherheitsfunktion falls der erste Prüfwert und der zweite Prüfwert ein Überprüfungskriterium erfüllen.

Abgasnachbehandlungs-Vorrichtung für eine Brennkraftmaschine

Automatische Oberleitungsführung

Ein System und Verfahren zum Führen eines geländegängigen Lastkraftwagens entlang eines Fahrwegs bezüglich eines Oberleitungsdrahts bestimmen eine Position des geländegängigen Lastkraftwagens auf dem Fahrweg durch Erfassen von zwei oder mehr Gegenständen am Fahrwegrand und nutzen die bestimmte Position des geländegängigen Lastkraftwagens und eine bekannte Position des Oberleitungsdrahts bezogen auf die zwei oder mehr Gegenstände am Fahrwegrand zum automatischen Bestimmen einer relativen Position des geländegängigen Lastkraftwagens unter dem Oberleitungsdraht. Auf der Basis der relativen Position des geländegängigen Lastkraftwagens unter dem Oberleitungsdraht wird der geländegängige Lastkraftwagen automatisch gelenkt, so dass die Position des geländegängigen Lastkraftwagens bezogen auf den Oberleitungsdraht z. B. zum Aufrechterhalten eines Flusses von elektrischer Energie von dem Oberleitungsdraht zu dem geländegängigen Lastkraftwagen verändert wird.

Systeme und Verfahren zur Minderung von NOx- und HC-Emissionen

Es werden Systeme und Verfahren zum Management von Niedrigtemperatur-NOx- und Niedrigtemperatur-HC-Emissionen bereitgestellt, wie etwa während eines Kaltstarts eines Verbrennungsmotors. Die Systeme und Verfahren umfassen das Speichern von NOx- und HC-Emissionen bei niedrigen Temperaturen und das passive Freisetzen und Behandeln dieser Emissionen bei einer Zunahme der Temperatur des Abgassystems.

Verfahren für einen fehlersicheren Betrieb eines netzwerksfähigen Steuerungssystems

Die Erfindung betrifft ein Verfahren für einen fehlersicheren Betrieb eines netzwerkfähigen Steuerungssystems, wobei das Steuerungssystem umfasst: mindestens eine Steuerung (1), mindestens eine Eingangsbaugruppe (30), die zwei oder mehr Signaleingänge (30A) aufweist, mindestens einen an die Eingangsbaugruppe (30) angeschlossenen Sensor (S, S1), der mit einem ersten Signaleingang (30A) der Eingangsbaugruppe (30) verbunden ist, wobei die Eingangsbaugruppe (30) über ein Kommunikationsnetzwerk (2) an die Steuerung (1) angeschlossen ist, wobei die Eingangsbaugruppe (30) der Aufbereitung und/oder Wandlung der Sensorsignale für eine Datenübertragung über das Kommunikationsnetzwerk (2) an die Steuerung (1) dient. Das Verfahren ist dadurch gekennzeichnet, dass mindestens eine Ausgangsbaugruppe (4) verwendet wird, die über das Kommunikationsnetzwerk (2) an die Steuerung (1) angeschlossen ist und mindestens einen Signalausgang (4A) aufweist, der mindestens eine Signalausgang (4A) der Ausgangsbaugruppe ...

Laser vibration sensor, system and method

A laser vibration sensor, system and method of vibration sensing employ a nanostructured resonance interactor. The sensor includes a resonator cavity of a laser and the nanostructured resonance interactor. The resonator cavity has a resonance deterministic of a characteristic of an output signal of the laser. The nanostructured resonance interactor modulates the resonance of the resonator cavity in response to a vibration. A change in the output signal characteristic induced by a resonance modulation is representative of the vibration. The system further includes an output signal detector. The method includes modulating a resonance characteristic of the resonator cavity using a nanostructure that responds to the vibration being sensed.

Active twist hollow beam system

A system for actively controlling the span-wise rotational twist of a hollow beam along its longitudinal axis, including a hollow beam structure having a leading edge and a trailing edge region, the beam being split along its length, an actuator arranged between split surfaces of the beam, the actuator adapted to move the split surfaces in a longitudinal direction relative to each other, inducing a twist in the beam. The hollow beam is affixed to an external structure at one or both ends, with only the zero warping displacement points of the beam being attached to the external structure, material or device. In one embodiment, the actuator is a plurality of solid blocks with high thermal expansion coefficients arranged between frames of the split surfaces of the beam, with alternating blocks being heated by resistance heaters to cause expansion in the spanwise longitudinal direction.

Method and apparatus for demagnetizing generator components prior to electromagnetic core imperfection testing or el-cid testing

A method and apparatus for determining and for reducing magnetism in a generator stator core ( 20 ). The method includes extending one or more conductors ( 38 ) proximate the core, applying a polarity-reversing excitation voltage to the one or more conductors, and reducing an amplitude of the voltage over time, wherein the voltage causes current to flow in the conductors, the current generating a magnetic field that demagnetizes the core. The method and apparatus are useful for determining hot spots in the core.

System and method for quality assurance of a biosensor test strip

The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.

Shipping Cap For Fire Protection Sprinkler

A shipping cap for a sprinkler includes a main body having a hollow annular wall portion having a closed upper end. A first pair of side legs extend laterally and axially from a first side of the cylindrical wall portion and a second pair of side legs extend laterally from a second side of the cylindrical wall portion. A first side curtain extends from one of the first pair of side legs and one of the second pair of side legs and a second side curtain extends from the other of the first pair of side legs and the other of the second pair of side legs.

NOVEL METHOD OF COMBINED MOLECULAR CLAMPING AND ALLELE SPECIFIC qPCR TECHNOLOGY FOR KRAS G12C MUTATION DETECTION

The invention provides a method for detecting KRAS mutations at one or more of codons, said method comprising the steps of: (a) extracting DNA from a biological sample; (b) assaying the DNA via PCR for KRAS mutations at one or more of codons with at least one set of oligonucleotides, wherein the at least one set of oligonucleotides comprises an allele specific forward primer, a reverse primer, a probe and a xenonucleic acid clamp to block amplification of wild type DNA. The xenonucleic acid clamps have aza-aza, thio-aza and oxy-aza chemical functionality. 1. A method of detecting KRAS mutations at one or more of codons; said method comprising: (a) providing a biological sample; (b) isolating DNA from said biological sample; said DNA including said KRAS mutations; (c) providing a first primer primer probe which is allele specific and a second primer probe; wherein said first and second primer probes are targeted to said KRAS mutations and wherein said primer probes allow formation of a PCR process product; (d) providing a target specific xenonucleic acid clamp oligomer probe specific for a wildtype polynucleotide sequence; so that during the qPCR process only mutant templates are amplified; (e) admixing the primer probes and the xenonucleic acid clamping probe with the target nucleic acid sample; (f) performing a PCR amplification process in a reaction solution under hybridization conditions thereby generating multiple amplicons; and (g) detecting said amplicons.2. The method of claim 1 , wherein the biological sample is obtained from a human or animal subject diagnosed with cancer.3. The method of claim 1 , wherein the biological sample is selected from the group consisting of formalin-fixed paraffin embedded (FFPE) tissue claim 1 , fresh frozen tumor specific tissue claim 1 , circulating tumor cells claim 1 , circulating cell-associated DNA from plasma claim 1 , and circulating non-cell associated DNA from plasma.4. The method of claim 1 , wherein the biological ...

Vehicular adaptive headlighting system

A vehicular adaptive driving beam headlighting system includes a camera disposed at and viewing forwardly through a windshield of a vehicle. A control includes an image processor that processes image data captured by the camera at night to detect headlights present in a field of view of the camera of an oncoming vehicle that is approaching the equipped vehicle along a traffic lane to the left of a traffic lane of a road that the equipped vehicle is travelling along. A left-side headlamp is disposed at a left-side front portion of the equipped vehicle and a right-side headlamp is disposed at a right-side front portion of the equipped vehicle. Responsive to detection of headlights of an oncoming vehicle, the left-side headlamp beam of light is adjusted to reduce glaring a driver of the oncoming vehicle.

SPECIFIC SYNTHETIC CHIMERIC XENONUCLEIC ACID GUIDE RNA; s(XNA-gRNA) FOR ENHANCING CRISPR MEDIATED GENOME EDITING EFFICIENCY

The invention provides specific synthetic chimeric xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing crispr mediated genome editing efficiency. The invention also provides methods and compositions for inducing CRISPR/Cas-based gene editing/regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using single guide RNAs (sgRNAs) that have been chemically modified with xeno nucleic acids which enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a sgRNA that has been chemically modified with xeno nucleic acids to correct a mutation in a target gene associated with the genetic disease. 1. RNA modified with a linker and a xenonucleic acid wherein said xenonucleic acid has functionality selected from the group consisting of azide , oxaaza and aza.2. The modified RNA of claim 1 , wherein said RNA is sgRNA.3. The modified RNA of claim 1 , wherein said RNA is crRNA.4. The modified RNA of claim 1 , wherein said RNA is tracrRNA.5. The modified RNA of claim 1 , having the formula:6. The modified RNA of claim 1 , wherein said RNA is chimeric.7. A method for inducing gene regulation of a target nucleic acid in a primary cell claim 1 , the method comprising: introducing into the primary cell:(a) a xenonucleic acid modified single guide RNA (sgRNA) comprising a first nucleotide sequence that is complementary to the target nucleic acid and a second nucleotide sequence that interacts with a CRISPR-associated protein (Cas) polypeptide, wherein one or more of the nucleotides in the first nucleotide sequence and/or the second nucleotide sequence are nucleotides which have been chemically modified with xenonucleic acids; and(b) a Cas polypeptide, an mRNA encoding a ...

Driver assistance system for vehicle

A driver assistance system for a vehicle includes a camera that, when disposed at the vehicle, views through a windshield of the vehicle. The camera is disposed at a windshield electronics module attached at the windshield of the vehicle. The camera captures image data of a scene forward of the vehicle. A control includes an image processor that processes captured image data. The control, responsive to the image processor processing captured image data, detects an object of interest external to the vehicle. The control utilizes a blockage detection algorithm and, responsive to the image processor processing captured image data, is operable to detect at least a partial blocking condition at the camera.

Dual function transducer

A dual function transducer assembly comprising: a magnet motor assembly comprising a first magnet plate and a second magnet plate arranged in parallel to one another along a first axis; a sound output assembly coupled to the magnet motor assembly, the sound output assembly comprising a piston and a voice coil, and wherein the voice coil is arranged to cause a vibration of the piston in a direction parallel to the first axis; and a shaker assembly coupled to the magnet motor assembly, the shaker assembly comprising a first shaker coil and a second shaker coil arranged to cause a vibration of the magnet assembly in a direction parallel to a second axis that is perpendicular to the first axis.

Ventilation mask

A nasal ventilation mask having one or more attachment ports located adjacent to and overlying an upper lip of a patient when worn.

Centrifugal separator

A centrifugal separator, such as a spin dryer that separates water from wet clothing includes a stationary chamber. A perforated basket is arranged to spin within the stationary chamber. A DC or AC motor is arranged below the bottom floor fastened to a mechanical floor. A driveshaft can be connected to the motor output shaft via a flexible coupling and passes through the bottom floor and is connected to the basket. A brake disc is operatively fixed to the output shaft, and a brake caliper is fixed to the mechanical floor to stop the brake disc. A balance ring, having an annular chamber holding a balance fluid, is mounted to an outside of the basket. The centrifugal separator can include a cycle controller that can ramp up or down the basket speed and reverse spinning direction of the basket.

Improved driveline for powersports vehicle

A Powersports vehicle is disclosed which includes a frame, ground engaging members supporting the frame, comprising at least two front wheel, and a power source for driving the front wheels. A front drive is coupled to the power source and to the front wheels, the front drive being coupled to the frame through isolation mounts to reduce vibration of the front drive through the frame.

DNA MUTATION DETECTION EMPLOYING ENRICHMENT OF MUTANT POLYNUCLEOTIDE SEQUENCES AND MINIMALLY INVASIVE SAMPLING

The invention relates to a method for enriching a target polynucleotide sequence containing a genetic variation said method comprising: (a) providing two primers targeted to said target polynucleotide sequence; (b) providing a target specific xenonucleic acid clamp oligomer specific for a wildtype polynucleotide sequence; (c) generating multiple amplicons using PCR under specific temperature cycling conditions; and (d) detecting said amplicons. 1. A method for enriching a target polynucleotide sequence containing a genetic variation said method comprising:(a) providing two primers targeted to said target polynucleotide sequence;(b) providing a target specific xenonucleic acid clamp oligomer specific for a wildtype polynucleotide sequence;(c) generating multiple amplicons using PCR under specific temperature cycling conditions; and(d) detecting said amplicons.2. The method of claim 1 , wherein said detection employs oligonucleotide probes specific for hybridization of variant polynucleotide amplicon sequences.3. The method of claim 1 , wherein the variant target sequence is in a gene selected from the group consisting of: KRAS claim 1 , BRAF claim 1 , EGFR claim 1 , TP53 claim 1 , JAK2 claim 1 , NPM1 claim 1 , and PCA3.4. A method for enriching multiple target polynucleotide sequences containing a genetic variation said method comprising:(a) providing a library of amplifying primers targeted to said multiple target polynucleotide sequence;(b) providing a library of target specific xenonucleic acid clamp oligomer specific for multiple wildtype polynucleotide sequences;(c) generating multiple amplicons using PCR under specific temperature cycling conditions; and(d) detecting said amplicons.5. The method of claim 3 , wherein said detection employs oligonucleotide probes specific for hybridization of variant polynucleotide amplicon sequences.6. A method for conducting a minimally invasive biopsy in a mammalian subject suspected of a having a neoplastic disease claim 3 , ...

Process and apparatus for quenching a reactor effluent stream

A process and apparatus cool and remove catalyst from a hot vaporous reactor effluent stream by feeding the hot vaporous reactor effluent stream comprising catalyst and a first quench liquid stream to a first quench chamber. The hot vaporous reactor effluent stream is directly contacted with the first quench liquid stream to cool the hot reactor effluent stream and wash catalyst therefrom into the first quench liquid stream. The first quench liquid stream and the vaporous reactor effluent stream are passed together through a bed while disengaging catalyst from the vaporous reactor effluent stream and transferring catalyst into the first quench liquid stream.

Object detection system

An object detection system for a vehicle includes a camera vision module and a Lidar module. The camera vision module includes an imaging device viewing to the exterior of the vehicle and operable to capture image data representative of a scene exterior and forward of the vehicle. The Lidar module includes a Lidar device that, with the Lidar module mounted at a front exterior portion of the vehicle, scans a region forward of the vehicle that overlaps with the field of view of the imaging device. Based at least in part on processing of captured image data by an image processor using vision processing algorithms and based at least in part on distance data provided by the Lidar device, 3-dimensional information relative to the vehicle of an object present exterior of the vehicle is algorithmically constructed.

SPECIFIC SYNTHETIC CHIMERIC XENONUCLEIC ACID GUIDE RNA; s(XNA-gRNA) FOR ENHANCING CRISPR MEDIATED GENOME EDITING EFFICIENCY

The invention provides xenonucleic acids and synthetic chimeric xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing crispr mediated genome editing efficiency. The invention also provides methods and compositions for inducing CRISPR/Cas-based gene editing/regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using single guide RNAs (sgRNAs) that have been chemically modified with xeno nucleic acids which enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a sgRNA that has been chemically modified with xeno nucleic acids to correct a mutation in a target gene associated with the genetic disease.

DNA MUTATION DETECTION EMPLOYING ENRICHMENT OF MUTANT POLYNUCLEOTIDE SEQUENCES AND MINIMALLY INVASIVE SAMPLING

The invention relates to a method for enriching a target polynucleotide sequence containing a genetic variation said method comprising: (a) providing two primers targeted to said target polynucleotide sequence; (b) providing a target specific xenonucleic acid clamp oligomer specific for a wildtype polynucleotide sequence; (c) generating multiple amplicons using PCR under specific temperature cycling conditions; and (d) detecting said amplicons. We introduce a novel molecule, Xenonucleic Acid (XNA) for the NGS library preparation. XNA is able to selectively suppress amplification of DNA with wild type alleles and amplify DNA containing mutant alleles. Mutants with low allelic frequency will be easily detectable without deep sequencing after enrichment by adding XNA in multiplex PCR. The 17 actionable mutants related to lung or colorectal cancer diseases at different variant allelic frequency (VAF)% were investigated. Clinical sensitivity is significantly improved with XNA in various types of samples.

System and method for integrating three dimensional video and galvanic vestibular stimulation

A method for providing galvanic vestibular stimulation corresponding to accelerations in scenes of a video. Embodiments include (1) receiving a three dimensional video signal including three dimensional video angular velocity information, (2) receiving a three dimensional head orientation signal including three dimensional head angular velocity information, (3) calculating resultant three dimensional angular velocity information based on the video angular velocity information and the head angular velocity information, (4) calculating three dimensional acceleration information based on the resultant three dimensional angular velocity information, and (5) generating three dimensional galvanic vestibular stimulation signals corresponding to the resultant three dimensional angular acceleration information, wherein the three dimensional stimulation signals will stimulate three dimensional acceleration sensations corresponding to accelerations on the user viewing the displayed scenes.

Dual-controller system for a sensorless brushless motor control

A power tool is provided including a brushless motor having a stator defining a plurality of phases and a rotor. A power unit is provided including power switches operable to deliver power to the motor. A primary controller is interfaced with the power unit to output drive signals to drive the phases of the motor over a series of sectors of the rotor rotation. The primary controller measures a back-electromotive force voltage of the motor and transitions motor commutation from the present sector to the next sector based in relation to the back-EMF voltage. A second controller is provided to receive at least one of the drive signals, calculate a speed and/or direction of rotation of the motor from the drive signals, and take corrective action to cut off supply of power to the motor if it detects an overspeed condition or incorrect direction of rotation.

Vehicular driver assistance system with construction zone recognition

A vehicular driver assistance system includes a camera that views through the windshield of the vehicle and a control device having an image processor that processes captured image data. Responsive to processing of captured image data by the image processor, the system adjusts a light beam emitted by a headlamp of the vehicle. The control device, responsive at least in part to image data processing by the image processor, determines when the vehicle is at a construction zone. Responsive to determination that the vehicle is at a construction zone, image processing of image data captured by the camera is adjusted to discriminate construction zone signs from taillights of leading vehicles. Responsive to determination of the vehicle exiting the construction zone, the control device adjusts the light beam emitted by the headlamp of the vehicle responsive to determination of headlamps of approaching vehicles and taillights of leading vehicles.

Integrated catalytic cracking and steam pyrolysis process for olefins

Integration of gas oil and light olefin catalytic cracking zones with a pyrolytic cracking zone to maximize efficient production of petrochemicals is disclosed. Integration of the units in parallel allows production of an overall product stream with maximum ethylene and/or propylene by routing various feedstreams and recycle streams to the appropriate cracking zone(s), e.g. ethane/propane to the steam pyrolysis zone and C 4 C 6 olefins to the light olefin cracking zone. This integration enhances the value of the material balances produced by the integrated units.

Process for the polymerization of olefins

Solution polymerization process

Disclosed herein is a system for solution polymerization comprising a reactor system that is operative to receive an anti-solvent, a monomer, and a solvent, and to react the monomer to form a polymer; where the anti-solvent is not a solvent for the polymer and is operative to reduce the lower critical solution temperature; a plurality of devolatilization vessels located downstream of the reactor system, where each devolatilization vessel operates at a lower pressure than the preceding devolatilization vessel and wherein the plurality of devolatilization vessels receives a polymer solution from the reactor system; and a liquid-liquid separator that is operative to receive a polymer solution from the reactor system and to facilitate a separation between the polymer and volatiles by reducing the pressure and temperature of the polymer solution in the liquid-liquid separator.

Solution polymerization process

Disclosed herein too is a method comprising charging to a reactor system a feed stream comprising a catalyst, a monomer and a solvent; reacting the monomer to form a polymer; where the polymer is contained in a single phase polymer solution; transporting the polymer solution to a pre-heater to increase the temperature of the polymer solution; charging the polymer solution to a liquid-liquid separator; reducing a pressure of the polymer solution in the liquid-liquid separator and separating a polymer-rich phase from a solvent-rich phase in the liquid-liquid separator; transporting the polymer-rich phase to a plurality of devolatilization vessels located downstream of the liquid-liquid separator, where each devolatilization vessel operates at a lower pressure than the preceding devolatilization vessel; and separating the polymer from volatiles present in the polymer rich phase.

Silicone polymer network compositions

A silicone composition containing a polyethersiloxane block copolymer network and a fluid within the network is useful as a component of various personal care compositions.

Polyether siloxane copolymer network compositions

A composition comprising the reaction products of M a M H b M E c D d D H e D E f T g T H h T E i Q j where M=R 1 R 2 R 3 SiO 1/2 ; M H =R 4 R 5 HSiO 1/2 ; M E =R 6 R 7 R E SiO 1/2 ; D=R 8 R 9 SiO 2/2 ; D H =R 10 HSiO 2/2 ; D E =R 11 R E SiO 2/2 ; T=R 12 SiO 3/2 ; T H =HSiO 3/2 ; T E =R E SiO 3/2 ; and Q=SiO 4/2 ; where R 1 , R 2 , R 3 , R 8 , R 9 and R 12 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms; R 4 , R 5 and R 10 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or hydrogen; R 6 , R 7 , R 11 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or R E ; each R E is independently a monovalent hydrocarbon radical containing one or more oxirane moieties having from one to sixty carbon atoms; the stoichiometric subscripts a, b, c, d, e, f, g, h, i, and j are either zero or positive subject to the following limitations: a+b+c>1; b+e+h>1; c+f+i>1; b+e+h>c+f+i; and when d+e+f+g+h+i+j=0, a+b+c=2. In a preferred embodiment the reaction product of the present invention is a polyether siloxane copolymer network. In another preferred embodiment embodiment the reaction product of the present invention is a polyether siloxane copolymer network swollen with a volatile low molecular weight silicon containing compound. These compositions are useful for a variety of personal care compositions.

Cosmetic compositions using polyether siloxane copolymer network compositions

A composition comprising the reaction products of M a M H b M E c D d D H e D E f T g T H h T E i Q j where M=R 1 R 2 R 3 SiO 1/2 ; M H =R 4 R 5 HSiO 1/2 ; M E=R 6 R 7 R E SiO 1/2 ; D=R 8 R 9 SiO 2/2 ; D H =R 10 HSiO 2/2 ; D E =R 11 R E SiO 2/2 ; T=R 12 SiO 3/2 ; T H =HSiO 3/2 ; T E =R E SiO 3/2 ; and Q=SiO 4/2 ; where R 1 , R 2 , R 3 , R 8 , R 9 and R 12 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms; R 4 , R 5 and R 10 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or hydrogen; R 6 , R 7 , R 11 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or R E ; each R E is independently a monovalent hydrocarbon radical containing one or more oxirane moieties having from one to sixty carbon atoms; the stoichiometric subscripts a, b, c, d, e, f, g, h, i, and j are either zero or positive subject to the following limitations: a+b+c>1; b+e+h>1; c+f+i>1; b+e+h>c+f+i; and when d+e+f+g+h+i+j=0, a+b+c=2. In a preferred embodiment the reaction product of the present invention is a polyether siloxane copolymer network. In another preferred embodiment embodiment the reaction product of the present invention is a polyether siloxane copolymer network swollen with a volatile low molecular weight silicon containing compound. These compositions are useful for a variety of personal care compositions.

Process for making cosmetic compositions using polyether siloxane copolymer network compositions

A method of making a cosmetic composition comprising the reaction products of M a M H b M E c D d D H e D E f T g T H h T E i Q j where M=R 1 R 2 R 3 SiO 1/2 ; M H =R 4 R 5 HSiO 1/2 ; M E =R 6 R 7 R E SiO 1/2 ; D=R 8 R 9 SiO 2/2 ; D H =R 10 HSiO 2/2 ; D E =R 11 R E SiO 2/2 ; T=R 12 SiO 3/2 ; T H =HSiO 3/2 ; T E =R E SiO 3/2 ; and Q=SiO 4/2 ; where R 1 , R 2 , R 3 , R 8 , R 9 and R 12 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms; R 4 , R 5 and R 10 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or hydrogen; R 6 , R 7 , R 11 are independently monovalent hydrocarbon radicals having from one to sixty carbon atoms or R E ; each R E is independently a monovalent hydrocarbon radical containing one or more oxirane moieties having from one to sixty carbon atoms; the stoichiometric subscripts a, b, c, d, e, f, g, h, i, and j are either zero or positive subject to the following limitations: a+b+c>1; b+e+h>1; c+f+i>1; b+e+h>c+f+i; and when d+e+f+g+h+i+j=0, a+b+c=2. In a preferred embodiment the reaction product of the present invention is a polyether siloxane copolymer network. In another preferred embodiment embodiment the reaction product of the present invention is a polyether siloxane copolymer network swollen with a volatile low molecular weight silicon containing compound. These compositions are useful for a variety of personal care compositions.

Glucose transport inhibitors and methods of use

Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.

Enhanced vision system and method for an aircraft

An aircraft optical display system for implementing an enhanced vision system based on weather conditions is described. The display system includes a plurality of imaging sensors configured to receive imaging input data and generate image data, where each imaging sensor is associated with one or more weather conditions. The system further includes a weather conditions input device configured to receive current weather condition information and a weather dependent imaging system configured to receive the current weather conditions information and to select one or more of the plurality of imaging sensors to provide imaging input data in accordance with the current weather conditions information.

Compact, passively athermalized optical assembly

An optical assembly comprises a light beam source, a collimating lens, and a passive thermally-compensated structure. Concentric rings of dissimilar material are supported by a baseplate and arranged to support a flexure plate at a predetermined distance above the baseplate. The collimating lens is mounted on the flexure plate. A difference in the thermal coefficient of expansion of the rings is chosen so that the flexure plate moves to compensate for thermal shifts in system focal length, while maintaining radial and angular alignment of the lens relative to the laser diode source, so as to provide controlled axial movement of the collimating lens.

Heterocyclic compounds and methods of use thereof

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Heterocyclic compounds and methods of use thereof

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Heterocyclic compounds and methods of use thereof

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Heterocyclic compounds and use thereof as modulators of type III receptor tyrosine kinases

Provided herein are heterocyclic compounds for treatment of CSFIR, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists

UV curable non-toxic epoxysilicone release coating compositions

There is provided a curable substantially uniform mixture of an epoxysilicone, a polyarylonium salt and a compatibilizer in the form a mixture of a long chain alkyl substituted phenol and an alkane diol. The curable mixture is convertable to a non-toxic, tack free adherent release coating for pressure sensitive adhesives.

Composite compositions

A curable resin composition for composites and electrical laminates including (I) at least one thermoset resin composition; (II) at least one hardener; and (III) at least one reinforcing material; wherein the composite or electrical laminate has a balance of properties including a combination of (a) a Tg of at least about 150°C; and (b) a water uptake of less than about 2.5 wt%.

System and method for manipulating a catheter for delivering a substance to a body cavity

A system and method for adjusting a catheter to create a medicated atmosphere in an organ, or body cavity is disclosed. The system comprises a catheter, such as an aerosolization catheter, that can be manipulated during use and an introduction device for the introduction and manipulation, by rotational and/or axial positioning, of the aerosolization catheter. The method includes inserting the catheter into a body cavity via an introducer apparatus and adjusting an angle or orientation of the exit end of the catheter so that a substance provided to the catheter will be controllably applied to the body cavity at desired locations.

Method of making a homogeneous mixture of polyolefin and liquid organic acid

A method of making a homogeneous mixture comprising a liquid hydrocarbylsulfonic acid and a polyolefin, the method comprising multiple stages of adding, mixing, and monitoring of temperature of the ingredients. The method enables making embodiments of the homogeneous mixture having more than 3 weight percent of the liquid hydrocarbylsulfonic acid incorporated into the polyolefin and prevents fouling of the mixer device.

Integrated light olefin separation/cracking process

Systems and methods for producing a hydrocarbon are provided. The method can include separating a hydrocarbon comprising olefins and paraffins to produce an olefin-rich hydrocarbon comprising about 70 wt % or more olefins and a paraffin-rich hydrocarbon comprising about 70 wt % or more paraffins. The method can also include cracking at least a portion of the olefin-rich hydrocarbon in the presence of one or more catalysts at conditions sufficient to produce a cracked product comprising about 20 wt % or more C 2 -C 3 olefins.

A technique for substantially eliminating temperature induced measurement errors from a corious meter

Process for the preparation of an aluminium alkyl growth product and its use in the oligomerisation of olefins

A process for the preparation of an aluminum alkyl chain growth product by the chain growth reaction of an α-olefin on an aluminum alkyl, optionally followed by displacement and recovery of the oligomeric alpha-olefin employing as a catalyst for the chain growth reaction a compositon comprising a Group 6 metal trisazacycloalkane complex and an activating cocatalyst.

Paintable material

A sealant material and articles incorporating the same. The sealant material includes up to about 80% of an epoxy resin; up to about 40% of an epoxy/elastomer hybrid; up to about 40% of a rheology modifier; up to about 5% of a blowing agent; up to about 7% of a curing agent; and about 40 to about 60% of a filler.

Two component (epoxy/amine) structural foam-in-place material

The present invention relates to methods, materials, and products for forming a foamed product, comprising the steps of combining an epoxy-based component with an amine-based component. The epoxy component is cross-linked through a polymerization reaction catalyzed by the amine formulation. In this regard, a reactive mixture or exothermic reaction is created between the epoxy component and the amine component when combined. The heat generated by the exothermic reaction softens a thermoplastic shell of a blowing agent formulated within the epoxy component thereby enabling a solvent core within the thermoplastic shell of the blowing agent to expand from the heat generated by the exothermic reaction.

Two-component (epoxy/amine) structural foam-in-place material

The present invention relates to methods, materials, and products for forming a foamed product, comprising the steps of combining an epoxy-based component with an amine-based component. The epoxy component is cross-linked through a polymerization reaction catalyzed by the amine formulation. In this regard, a reactive mixture or exothermic reaction is created between the epoxy component and the amine component when combined. The heat generated by the exothermic reaction softens a thermoplastic shell of a blowing agent formulated within the epoxy component thereby enabling a solvent core within the thermoplastic shell of the blowing agent to expand from the heat generated by the exothermic reaction.

Structural hot melt material and methods

The present invention relates to a material, method, and application for reinforcement of structural members, especially joints such as a hem flange joint of an automobile. The method and material of the present invention comprises of combining, in parts by weight: less than about twenty percent (<20%) ethylene copolymer, less than about forty percent (<40%) epoxy, less than about thirty percent (<45%) epoxy-based resin, less than about two percent (<2%) blowing agent and from about one percent (1%) to about five percent (5%) curing agent (and optionally add any of the following components: less than about two percent (<2%) curing agent accelerator, from about twenty-five percent (25%) to fifty-five percent (55%) filler, and less than about one percent (<1%) of coloring agent). The application of the present invention comprises of: (1) providing a structural member having two substrates forming a space to be joined; (2) placing the material of the present invention in proximity of the space to be joined; (3) exposing the material to a heat source causing it to flow, fill, and cure in the defined area or space to be joined.

Activatable material

An activatable (e.g., heat expandable) material and articles incorporating the same is disclosed. The material includes an epoxy resin; an epoxy/elastomer hybrid or reaction product; a blowing agent; a curing agent; and optionally, a filler. In preferred embodiments, the material includes aramid fiber, nanoclay or both.

Tacky base material with powder thereon

A synthetic material comprises a base material providing at least one tacky surface that is tacky at a temperature of less than about 80° C.; and a powder layered upon the base material which has a substantially non-tacky surface at a temperature of up to about 40° C. and exhibits adhesiveness at a temperature of greater than 120° C. The powder includes one or more correspondence components such as an epoxy resin which is either i) substantially identical to a component of the base material, or ii) the monomer or oligomer configuration of the correspondence component is substantially identical to a component of the base material but may have a greater molecular weight or longer polymer chain structure, or iii) is insubstatantially different from a component of the base material (e.g. has the same characteristics and a similar structure but a higher molecular weight).

Synthetic material and methods of forming and applying same

A synthetic material and articles incorporating the same are disclosed. The synthetic material includes a base material, which is at least partially tacky. Preferably, a powder is dispensed upon the base material for providing a substantially non-tacky surface to the synthetic material.

Process for preparing a coupled polymer, composition, article and use thereof

"PROCESSO PARA PREPARAR UM POLìMERO ACOPLADO,COMPOSIçãO, ARTIGO E USO DO MESMO". A invenção incluium processo para preparar um polímero acoplado compreendendoaquecer uma mistura contendo: 1) pelo menos uma poliolefinacompreendendo etileno e pelo menos um comonómero que éselecionado de alfa-olefinas tendo pelo menos 3 átomos decarbono, dienos e 2) uma quantidade acopladora de pelo menosuma poli(sulfonil azida). A poliolefina é o produto da polimerizaçãode etileno e pelo menos uma outra alfa-olefina na presença de umúnico catalisador local (metal de transição como Va ou Cr,metaloceno, ou geometria restringida).

Impact modification of polyesters via reactive extrusion with polyacrylated epoxidized high oleic soybean oil

The present application relates to a thermoplastic graft copolymer including one or more thermoplastic polymers of formula (I): and a branched chain thermoplastic polymer of formula (II): where R1, R2, R3, R4, R4', AETAG, a, b, c, d, and e are as described herein. Also disclosed is the process for preparing the thermoplastic copolymer and its uses.

Polymerization and isolation of low viscosity polymers using pastillation technology

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel proteins are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Polynucleotides and the proteins encoded thereby are disclosed.

SECRETED EXPRESSED SEQUENCE TAGS (sESTs)

Secreted expressed sequence tags (sESTs) isolated from a variety of human tissue sources are provided.

SECRETED EXPRESSED SEQUENCE TAGS (sESTs)

Secreted expressed sequence tags (sESTs) isolated from a variety of human tissue sources are provided.

SECRETED EXPRESSED SEQUENCE TAGS (sESTs)

Secreted expressed sequence tags (sESTs) isolated from a variety of human tissue sources are provided.

Secreted proteins and polynucleotides encoding them

Polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

Novel polynucleotides and the proteins encoded thereby are disclosed.

Vehicular imaging system in an automatic headlamp control system

A vehicular imaging system includes a forward facing photosensor array and a control responsive to the photosensor array. The control processes an image data set indicative of captured images, and the control processes a reduced image data set of the image data set to determine whether an object of interest is within a target zone of the captured image. The reduced image data set is representative of a portion of the captured images as captured by a particular grouping of the photosensor elements. The control adjusts the reduced image data set so as to be representative of a portion of the captured images as captured by a different particular grouping of the photosensor elements, and adjusts the reduced image data set in response to a determination of a change in a focus of expansion of the captured images.

Imaging system for vehicle

A vehicular imaging system includes an imaging device that captures image data and a control for processing captured image data. The control may utilize edge detection in processing captured image data. Responsive at least in part to processing of captured image data by the control, the control determines objects of interest present in the field of view of the imaging device. The objects of interest determined to be present in the field of view of the imaging device include at least one of (i) vehicles present exterior of the vehicle, (ii) headlights of vehicles present exterior of the vehicle, (iii) a bicycle that is present exterior of the vehicle and (iv) a bicycle rider that is present exterior of the vehicle. Responsive at least in part to processing of captured image data by the control, a driver of the vehicle is alerted to a hazardous condition.

Imaging system for vehicle

An imaging system for a vehicle includes an imaging array sensor and a control. The imaging array sensor has a plurality of photo-sensing pixels and is positioned at a vehicle equipped with the imaging system and has a field of view exteriorly of the equipped vehicle. The imaging array sensor is operable to capture image data, and the control processes the captured image data. The control, responsive to the processing of the captured image data, may distinguish an object present in the field of view of the imaging array sensor from a shadow present in the field of view of the imaging array sensor. The control, responsive at least in part to the processing of the captured image data, determines an object of interest present in the field of view of the imaging array sensor.

Imaging system for vehicle

An imaging system for a vehicle includes an imaging array sensor and a control. The image array sensor comprises a plurality of photo-sensing pixels and is positioned at the vehicle with a field of view exterior of the vehicle. The imaging array sensor is operable to capture an image exterior of the vehicle. The control may process the captured images and may determine that the imaging array sensor is not aligned within a desired tolerance when the imaging array sensor is positioned at the vehicle. The control, responsive to a determination of a misalignment of the imaging array sensor at the vehicle, may adjust at least one of the captured images or an image data set and the image processing to at least partially compensate for the determined misalignment of the imaging array sensor.

Imaging system for vehicle

An imaging system for a vehicle includes an imaging array sensor and a control. The imaging array sensor is disposed at least partially within an exterior rearview mirror assembly that is attached at a side of a vehicle. The field of view of the imaging array sensor encompasses at least one of a rearward field of view, a sideward field of view and a forward field of view. The control may utilize edge detection in processing captured image data. Responsive at least in part to processing of captured image data by the control, the control determines an object of interest present in the field of view of the imaging array sensor. A portion of the equipped vehicle is present in the field of view of the imaging array sensor and the control may be operable to determine that the portion of the equipped vehicle is not an object of interest.

Imaging system for vehicle

An imaging system for a vehicle includes an imaging array sensor and a control. The imaging array sensor comprises a plurality of photo-sensing pixels and is disposed at an exterior rearview mirror assembly at a side of the vehicle with a field of view exterior of the vehicle. The imaging array sensor is operable to capture an image exterior of the vehicle. The control may process the captured images and may determine that the imaging array sensor is misaligned when the imaging array sensor is disposed at the exterior rearview mirror assembly at the side of the vehicle. The control, responsive to a determination of misalignment of the imaging array sensor, may at least partially compensate for the determined misalignment of the imaging array sensor.

Imaging system for vehicle

A vehicular imaging system includes an imaging device that is part of an exterior rearview mirror assembly and having a field of view rearward and/or sideward of the vehicle. A control processes captured image data utilizing edge detection. Responsive at least in part to the processing, the control determines objects of interest present in the field of view of the imaging device. Objects of interest determined to be present in the field of view include (i) a vehicle that is rearward and/or sideward of the vehicle, (ii) a headlight of a vehicle that is rearward and/or sideward of the vehicle, (iii) a bicycle that is rearward and/or sideward of the vehicle, and/or (iv) a bicycle rider that is rearward and/or sideward of the vehicle. Responsive at least in part to the processing of captured image data, a driver of the vehicle is alerted to a hazardous condition.

Object detection system for vehicle

An imaging system for a vehicle includes an imaging array sensor and a control. The image array sensor comprises a plurality of photo-sensing pixels and is positioned at the vehicle with a field of view exterior of the vehicle. The imaging array sensor is operable to capture an image exterior of the vehicle. The control may process the captured images and may determine that the imaging array sensor is not aligned within a desired tolerance when the imaging array sensor is positioned at the vehicle. The control, responsive to a determination of a misalignment of the imaging array sensor at the vehicle, may adjust at least one of the captured images or an image data set and the image processing to at least partially compensate for the determined misalignment of the imaging array sensor.

Object detection system for vehicle

An imaging system for a vehicle includes an imaging array sensor and a control. The image array sensor comprises a plurality of photo-sensing pixels and is positioned at the vehicle with a field of view exteriorly of the vehicle. The imaging array sensor is operable to capture an image of a scene occurring exteriorly of the vehicle. The captured image comprises an image data set representative of the exterior scene. The control algorithmically processes the image data set to a reduced image data set of the image data set. The control processes the reduced image data set to extract information from the reduced image data set. The control selects the reduced image data set based on a steering angle of the vehicle.

Imaging system for vehicle

A vehicular imaging system includes a camera with an imaging sensor. A red-pass spectral filter is disposed at each pixel of a first set of photosensing pixels, a blue-pass spectral filter is disposed at each pixel of a second set of photosensing pixels, a green-pass spectral filter is disposed at each pixel of a third set of photosensing pixels, and each pixel of a fourth set of photosensing pixels senses at least near infrared radiation. A near infrared illumination source is operable to emit non-visible near infrared illumination to enhance nighttime viewing by the camera. Outputs of the pixels of the first, second and third sets of photosensing pixels are processed for at least one of (i) a lane departure warning system and (ii) an object detection system. Output of the photosensing pixels of the fourth set of photosensing pixels is processed for a night vision system.

Imaging system for vehicle

A vehicular imaging system includes a camera with an imaging sensor. A first spectral filter is disposed at each pixel of a first set of photosensing pixels, a second spectral filter is disposed at each pixel of a second set of photosensing pixels, and each pixel of a third set of photosensing pixels senses at least near infrared radiation. Image data provided to the image processor includes output of the first set of photosensing pixels, output of the second set of photosensing pixels and output of the third set of photosensing pixels. The outputs of the photosensing pixels of the first and second sets of photosensing pixels are processed for a color camera function of the vehicle. The output of the photosensing pixels of the third set of photosensing pixels is processed for a night vision function of the vehicle.

Imaging system for vehicle

An imaging system suitable for use in a vehicle includes an imaging sensor having a two-dimensional array of photosensing pixels that includes at least one sub-array having a first photosensing pixel, a second photosensing pixel, a third photosensing pixel and a fourth photosensing pixel. Spectral filtering is disposed at the photosensing pixels whereby the first photosensing pixel primarily senses red visible light, the second photosensing primarily senses blue visible light, the third photosensing primarily senses green visible light and the fourth photosensing primarily senses infrared radiation. The imaging sensor is disposed at a vehicle and has a field of view external of the vehicle. An image processor is operable for processing image data captured by the imaging sensor. The image data includes outputs of the first, second, third and fourth photosensing pixels. The processing of image data by the image processor may include de-mosaicing that reduces infrared color wash-out.

Vehicular control system with temperature input

A vehicular control system includes a camera, a controller having a processor that processes captured image data, and an exterior temperature sensor. Responsive, at least in part, to a temperature input from the temperature sensor, the controller switches processing of captured image data between (a) a normal processing mode and (b) a cold weather processing mode. Responsive to the temperature input being indicative of the exterior temperature being below a first threshold temperature, the controller processes captured image data in the cold weather processing mode to enhance blockage detection of frost or snow or ice at the camera. When the controller is operating in the cold weather processing mode, the controller switches processing of captured image data to the normal processing mode responsive to the temperature input being indicative of the exterior temperature being above a second threshold temperature that is greater than the first threshold temperature.

Driver assistance system for vehicle

A driver assistance system for a vehicle includes a camera that, when disposed at the vehicle, views through a windshield of the vehicle. The camera is disposed at a windshield electronics module attached at the windshield of the vehicle. The camera captures image data of a scene forward of the vehicle. A control includes an image processor that processes captured image data. The control, responsive to the image processor processing captured image data, detects an object of interest external to the vehicle. The control utilizes a blockage detection algorithm and, responsive to the image processor processing captured image data, is operable to detect at least a partial blocking condition at the camera.

Driver assistance system for vehicle

A driver assistance system for a vehicle includes an imaging device disposed at an exterior portion of a vehicle. With the imaging device disposed at the exterior portion of the vehicle, the imaging device has a field of view at least one of rearward of the vehicle and sideward of the vehicle. A control utilizes edge detection in processing image data captured by the imaging device. Responsive at least in part to processing of captured image data by the control, the control determines that an object is present in the field of view of the imaging device. The control is operable to determine that the imaging device is misaligned. The control, responsive to a determination of misalignment of the imaging array sensor, is operable to at least partially compensate for the determined misalignment of the imaging device.

Driver assistance system for vehicle

A driver assistance system for a vehicle includes an imaging device disposed at least partially within an exterior rearview mirror assembly of the vehicle. With the exterior rearview mirror assembly attached at a side of the vehicle, the imaging device has a field of view forward of the mirror assembly, rearward of the mirror assembly and sideward of the mirror assembly. A control processes image data captured by the imaging device and is operable to determine that the imaging device is misaligned when the imaging device is disposed at least partially within the exterior rearview mirror assembly at the side of the equipped vehicle. The control, responsive to a determination of misalignment of the imaging device, is operable to at least partially compensate for misalignment of the imaging device by at least one of (i) adjusting processing of captured image data and (ii) adjusting the captured image data.

Driver assistance system for vehicle

A driver assistance system for a vehicle includes first and second cameras and a rear backup camera. A control processes image data captured by the first camera and determines that the first camera is misaligned when the first camera is disposed at the left side of the vehicle. The control, responsive to a determination of misalignment of the first camera, is operable to algorithmically at least partially compensate for misalignment of the first camera. At least in part responsive to processing of captured image data, a composite image is displayed that provides a view that approximates a view from a single virtual camera. Image data captured at least by the first camera is processed using an edge detection algorithm to detect edges of objects exterior of the vehicle. Responsive at least in part to processing of captured image data, an object of interest exterior of the vehicle is determined.