11-04-2019 дата публикации
Номер: US20190104738A1
Автор:
Arun NARINE,
Ashokkumar ADISECHAN,
Rupsha CHAUDHURI,
Gopal Krishna DATTA,
Sunderraman SAMBASIVAN,
Devendra VYAS,
NARINE ARUN,
ADISECHAN ASHOKKUMAR,
CHAUDHURI RUPSHA,
DATTA GOPAL KRISHNA,
SAMBASIVAN SUNDERRAMAN,
VYAS DEVENDRA,
NARINE, Arun,
ADISECHAN, Ashokkumar,
CHAUDHURI, Rupsha,
DATTA, Gopal Krishna,
SAMBASIVAN, Sunderraman,
VYAS, Devendra
Принадлежит:
The present invention relates to compounds of formula I, 115-. (canceled)17. The compound of formula (I) according to claim 16 , wherein P is N(R) and Q is C(R).18. The compound of formula (I) according to claim 16 , wherein P is C(R) and Q is N(R).20. The compound of formula (I-A) according to claim 19 , wherein{'sup': 'x', 'sub': 1', '3', '2', '3', '2', '3', '3', '6', '1', '3, 'Ris selected from C-Calkyl, C-Calkenyl, C-Calkynyl, C-Ccycloalkyl, and C-Chaloalkyl;'}{'sup': '1', 'sub': 1', '6', '1', '6', '1', '6', '1', '6, 'Ris selected from partially or completely halogenated, C-Calkyl, C-Csulfenyl, C-Csulfinyl, and C-Csulfonyl;'}{'sup': '2', 'sub': 3', '2', '5, 'Ris selected from H, CH, CH, n-propyl, isopropyl, cyclopropyl, allyl and propargyl;'}{'sup': '4', 'sub': 3', '2', '5, 'Ris selected from H, CH, CH, n-propyl, isopropyl, cyclopropyl, allyl and propargyl;'}{'sup': 'Ar', 'Ar is a phenyl or 5- or 6-membered heteroaryl substituted with R;'}{'sup': Ar', 'e', 'f, 'sub': 1', '6', '1', '6', '1', '6', '1', '6', 'm, 'Ris selected from halogen, C-Calkyl, C-Chaloalkyl, C-Calkoxy, C-Chaloalkoxy, S(═O)R, phenyl, phenoxy, phenylcarbonyl, phenylthio and benzyl, wherein the phenyl ring is unsubstituted or substituted by radicals R;'}{'sup': 'e', 'sub': 1', '3', '3', '6', '1', '3', '3', '6, 'Ris selected from C-Calkyl, C-Ccycloalkyl, C-Chaloalkyl, and C-Chalocycloalkyl;'}{'sup': 'f', 'sub': 3', '2', '5', '3', '2', '5', '3', '2', '5', '3', '2', '2', '3, 'Ris selected from Cl, F, Br, OCH, OCH, SCH, SCH, CN, CH, CH, n-propyl, isopropyl, cyclopropyl, allyl, propargyl, CF, CHF, and CFCF.'}21. The compound of formula (I-A) according to claim 19 , wherein{'sup': 'x', 'sub': 3', '2', '5, 'Ris CHor CH;'}{'sup': '1', 'sub': 3', '2', '3', '3', '2', '3', '3', '2', '3', '2', '3, 'Ris selected from CF, CFCF, CF(CF), SCF, OCF, OCHF, S(═O)CF, and S(═O)CF;'}{'sup': '2', 'sub': 3', '2', '5, 'Ris selected from H, CH, and CH;'}{'sup': '4', 'sub': 3', '2', '5, 'Ris selected from H, CH, and CH;'}{' ...
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