LASER WELDING STATION

OR A HOT AIR OVEN WITH AIR CIRCULATION.

INSTALLATION OF WELDING THE LASER

L'invention concerne un dispositif pour assembler des pièces (8) par rayonnement laser, selon lequel au moins deux éléments sont assemblés le long d'une ligne de jointure prédéfinie au moyen d'un cordon de jointure, avec un porte-pièce (5) mobile le long d'une voie de guidage (3',6), avec des moyens pour produire un rayon laser et avec une tête laser (13) disposée à poste fixe, avec une position de jointure où les éléments sont joints par des moyens de jointure et avec une position de soudage avec des serre-flans (10) pouvant être appliqués sur la surface de la pièce, sachant que le porte-pièce (5) peut être déplacé entre la position de jointure et la position de soudage. Selon l'invention, afin de traiter des pièces (8) de différentes dimensions, il est prévu au moins deux moyens de jointure différents et deux serre-flans différents (10), qui sont adaptés aux dimensions respectives de la pièce et qui peuvent être automatiquement utilisés au choix en fonction des besoins.

FURNACE HAS HOT AIR OR HAS CIRCULATION Of AIR.

Le four à air chaud ou à circulation d'air est doté d'un espace de cuisson présentant une porte de four côté avant avec plusieurs niveaux de support d'article à cuire, une chambre de soufflerie (4) séparée de l'espace de cuisson par une plaque de conduction d'air (2) et contenant une soufflerie, laquelle plaque de conduction d'air (2) présente une ouverture d'aspiration centrale, plusieurs ouvertures de sortie d'air débouchant dans l'espace de cuisson et une ouverture (10) pour un canal (5) non ventilé, traversant la chambre de soufflerie (4) ventilée par la soufflerie jusqu'à la limitation (1) côté arrière de l'espace de cuisson, en tant que composant séparé, lequel canal est guidé vers l'arrière de la plaque de conduction d'air (10) et une barrière d'écoulement d'aération étant prévue dans la zone entre le canal (5) et l'ouverture (10) de la plaque de conduction d'air (2), par exemple sous la forme d'un élément d'étanchéité (12) élastique et résistant à la chaleur.

Hydroforming die assembly and method for pinch-free tube forming

DEVICE HAVING A PAIR OF ELECTRODES AND AT LEAST ONE PARTICLE HAS SPIN STATE TRANSITION TO THE CONTACT ELECTRODES, METHOD FOR PRODUCTION THEREOF AND DIFFERENT USES OF THE DEVICE.

L'invention concerne un dispositif (100) comprenant : - au moins deux électrodes (20, 21), chaque électrode comportant au moins un matériau ferromagnétique susceptible de présenter une couche de couverture en matériau non-ferromagnétique d'épaisseur inférieure à 40nm, les extrémités (201, 211) de ces électrodes (20, 21) étant disposées face à face de sorte que la distance (DF) entre les matériaux ferromagnétiques (200, 210) des électrodes est comprise entre 1nm et 1 micron ; - un moyen pour appliquer un champ magnétique externe (H0) afin de magnétiser lesdites électrodes (20, 21) ; - au moins une particule à transition d'état électronique de spin au contact des deux électrodes, l'état électronique de spin de ladite au moins une particule étant commandable par un stimulus, par exemple un stimulus de température et ladite au moins une particule étant par ailleurs dépourvue de matériau ferromagnétique. L'invention concerne également un procédé de fabrication d'un tel dispositif et différentes ...

METHOD FOR PRODUCING CELL OF A TURBOMACHINE DISK

N-(protegido- n-(3-metoxi-5-metilpirazon-2-il)-2-(4-[1,3,4-oxadiazol-2-il]fenil)piridino-3-sulfonamida y su proceso de preparacion.

Proceso para preparar n-(3-metoxi-5-metilpirazin-2-il)-2-(4-[1,3,4-oxadiazol-2-il]fenil)piridino-3-sulfonamida combinando el ácido [4-(1,3,4-oxadiazol-2-il)fenil]borónico con n-(3-metoxi-5-metilpirazin-2-il)-2-(cloro)piridino-3-sulfonamida.

Cyclic oxosilane

Verfahren zur kontinuierlichen Herstellung von Epichlorhydrin

用于探测窗玻璃上的湿润的传感器装置

... 提出一种用于探测窗玻璃(13)上的湿润、特别是凝结物和沾污的传感器装置，具有至少一个发射器(14)和至少一个用于从发射器(14)发射出的发射光(17)的接收器(15)，其中，发射器(14)和接收器(15)安置在一个假想梯形的四个顶点上。由此减小了传感器的外形尺寸，改善了传感器敏感面积(19)与基面(18)的比例关系，并且形成一个连贯的敏感面积，其中，还具有用于一个自动光量控制装置的接收元件的空间。 ...

环状硅氮烷

... 本发明涉及具有化学通式II的环状硅氮烷：∴R是二价的、Si-C及Si-N键合的、选择性地被氰基或卤素取代的C#-[3]-C#-[15]-烃基，其中一个或多个彼此不相邻的亚甲基单元可由-O-、-CO-、-COO-、-OCO-、-OCOO-、-S-或-NR#+[X]-基代替，而且其中一个或多个彼此不相邻的次甲基单元可由-N＝、-N＝N-或-P＝基代替，其中该环内硅原子与氮原子之间有至少3个及至多6个原子，R#+[X]是氢或选择性地被卤素取代的C#-[1]-C#-[10]-烃基，及：R#+[2]是氢原子或单价的、选择性地被氰基或卤素取代的、Si-C键合的C#-[1]-C#-[20]-烃基或C#-[1]-C#-[20]-烃氧基，在上述每个基团内一个或多个彼此不相邻的亚甲基单元可由-O-、-CO-、-COO-、-OCO-、-OCOO-、-S-或-NR#+[X]-基代替，而且其中一个或多个彼此不相邻的次甲基单元可由-N＝、-N＝N-或-P＝基代替。 ...

Booster steering device with hydraulic booster

Method and device for detecting a thickening in a running thread

Forced ignition IC engine with multiple cylinders

Nonodorous ethylene homopolymers and copolymers having good mechanical properties

Sensing device for detecting wetness on a glass pane

Mezcla herbicida que contiene picolinafeno y por lo menos un compuesto herbicida seleccionado entre acidos quinolincarboxilicos, quinclorac o el quinmerac; agente herbicida que contiene la mezcla; procedimiento para preparar dicho agente herbicida. (divisional 523-04)

Mezcla herbicida que contiene picolinafeno (i) y por lo menos un compuesto herbicida seleccionado entre ácidos quinolin carboxílicos, quinchlorac o el quinmerac; agente herbicida que contiene la mezcla; procedimiento para preparar dicho agente herbicida.

Device for detecting a thickening in a running thread

Hacking machine

The utility model provides a hacking machine, which comprises a frame, first horizontal running gear, vertical lift mechanism and manipulator, first horizontal running gear sets up in the frame, first horizontal running gear can drive vertical lift mechanism for frame horizontal migration, vertical lift mechanism can drive the manipulator and carry out vertical reciprocating, vertical lift mechanism includes a perpendicular roof beam, below erecting the roof beam is equipped with the horizontal running gear of second, the horizontal running gear of second can drive the manipulator for erecting roof beam horizontal migration, and the manipulator is mutually perpendicular for the horizontal migration direction of frame with vertical lift mechanism for the horizontal migration direction of erecting the roof beam. Simple structure is compact, and the installation space that equipment needs is little, and manipulator motion scope is big, and production efficiency is high, and the maintenance ...

Method and Composition for Treating Migraines

A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner. 1. A method of treating symptoms associated with migraine comprising:administering to a subject in need of treatment for migraine symptoms a dry powder pharmaceutical composition comprising an effective amount of a serotonin receptor agonist and a diketopiperazine or a salt thereof.2. The method of claim 1 , wherein the dry powder pharmaceutical composition is administered by inhalation.3. The method of claim 1 , wherein said diketopiperazine is 2 claim 1 ,5-diketo-3 claim 1 ,6-di(4-X-aminobutyl)piperazine; wherein X is selected from the group consisting of succinyl claim 1 , glutaryl claim 1 , maleyl claim 1 , and fumaryl; or a pharmaceutically acceptable salt thereof.4. The method of claim 1 , wherein the dry powder pharmaceutical composition is manufactured as a unit dose for oral inhalation.5. The method of claim 4 , wherein said inhalable dry powder pharmaceutical composition further comprises a pharmaceutically acceptable carrier or excipient.6. The method of claim 4 , wherein the dry powder formulation is administered to said patient by pulmonary inhalation using a breath powered claim 4 , dry powder inhalation system.7. The method of claim 1 , wherein the serotonin receptor agonist is for treating moderate to severe head pain associated with the migraine.8. The method of claim 1 , wherein the serotonin receptor agonist is a triptan.9. The method of claim 8 , wherein the triptan is selected from the group consisting of sumatriptan claim 8 , almotriptan claim 8 , eletriptan claim 8 , frovatriptan claim 8 , naratriptan claim 8 , rizatriptan claim 8 , ...

Management of breakthrough bleeding in extended hormonal contraceptive regimens

The present invention relates to a flexible extended use regimen for a hormonal contraceptive useful to manage bleeding problems associated with fixed extended use of hormonal contraceptives and to a pharmaceutical package containing the respective hormonal contraceptive.

METHOD FOR OPERATING A NETWORK AND A NETWORK

For allowing a reliable communication between the wireless part and the core network part via the fixed line network a method for operating a network, especially for policy control within the network, is provided, wherein the network includes a mobile network and a fixed line network, wherein the mobile network includes a wireless part and a core network part and wherein the mobile network and the fixed line network cooperate for providing communication between the wireless part and the core network part via the fixed line network. The method is characterized in that information regarding the wireless part will be provided via the mobile network to the fixed line network for controlling the communication within the fixed line network. Further, a corresponding network, preferably for carrying out the above mentioned method is disclosed.

System and method of generating a route across an electronic map

A computerised method of generating a route 1000 from an origin position F 1 to a destination position 706 across an electronic map 700 comprising a plurality of vectors representing segments of a navigable route in the area covered by the electronic map 700, the method comprising: (1) obtaining delay data indicating delays on vectors within the area covered by the electronic map 700; (2) calculating a first portion 1002 of a route from origin position toward the destination position 706 using a first routing method up to a predetermined threshold 1006 from the origin position F 1, such that the first routing method uses the delay data so that the first portion 1002 of the route takes into account delays; and (3) calculating a second portion 1004 of the route beyond the predetermined threshold 1006 to the destination position 706 using a second routing method to further calculate the route to the destination position 1006.

Delivery of Active Agents

A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site. 1. A method of administering a labile active agent to a patient in need thereof comprising:administering by inhalation a pharmaceutical composition comprising the labile active agent associated with a diketopiperazine microparticle wherein the active agent is subject to degradation in a patient as a result of exposure to peripheral tissue, vascular venous tissue, or liver metabolism, and wherein the effectiveness of said active agent is reduced by said degradation prior to reaching the agent's site of action.2. The method of claim 1 , wherein said diketopiperazine is 2 claim 1 ,5-diketo-3 claim 1 ,6-di(4-X-aminobutyl)piperazine; wherein X is selected from the group consisting of succinyl claim 1 , glutaryl claim 1 , maleyl claim 1 , and fumaryl; or a pharmaceutically acceptable salt thereof.3. The method of claim 1 , wherein the pharmaceutical composition is a dry powder formulation.4. The method of claim 3 , wherein said dry powder formulation further comprises a pharmaceutically acceptable carrier or excipient.5. The method of claim 3 , wherein the dry powder formulation is administered using a dry powder inhalation system.6. The method of claim 1 , wherein the active agent is a protein claim 1 , a peptide claim 1 , or an analog thereof.7. The method of claim 1 , wherein the active agent is an endocrine hormone or an analog thereof.8. The method of ...

Coupling for a multi-part dental implant system

The invention relates to an abutment for use in a dental implant system, wherein the abutment is provided with a guiding and lock means for associating the abutment to a dental implant, the guiding and lock means including: a first conically tapered section; a second substantially non-tapered section arranged apically adjacent to the first section, the second section being provided with an anti-rotational means; and a third substantially circular cylindrical section arranged apically adjacent to the second section, such that to provide axial guiding to the abutment upon the insertion thereof into a dental implant. Further, the invention relates to a dental implant formed in a similar manner.

METHOD AND BASE STATION FOR SUPPORTING A CONNECTION BETWEEN A COMMUNICATION DEVICE AND A DESTINATION DEVICE IN A TARGET NETWORK

A method for supporting a connection between a communication device and a destination device in a target network over intermediate network nodes, in particular in the context of Internet Protocol based communication, wherein data between the communication device and the destination device is transmitted via a tunnel established between the communication device or a base station connected to the communication device, as a first tunnel endpoint and a gateway in the target network as a second tunnel endpoint. One or more dummy packets are sent via the tunnel from the first tunnel endpoint towards the second tunnel endpoint, information is encoded in the packet headers of the one or more dummy packets, and at least one of the intermediate network nodes, upon receiving the one or more dummy packets, performs the steps of detecting and/or decoding the encoded information and performing a predefined action dependent on the encoded information. 1. Method for supporting a connection between a communication device and a destination device in a target network over intermediate network nodes , in particular in the context of Internet Protocol (IP) based communication ,wherein data between said communication device and said destination device is transmitted via a tunnel,wherein said tunnel is established between said communication device or a base station, to which said communication device is connected, as a first tunnel endpoint and a gateway in said target network as a second tunnel endpoint, characterized in that one or more dummy packets are sent via said tunnel from said first tunnel endpoint towards said second tunnel endpoint,wherein information is encoded in the packet headers of said one or more dummy packets, andwherein at least one of said intermediate network nodes, upon receiving said one or more dummy packets, performs the steps of detecting and/or decoding said encoded information and performing a predefined action dependent on said encoded information.2. Method ...

METHOD AND SYSTEM FOR CONNECTING A USER EQUIPMENT TO A NETWORK DEVICE VIA A MOBILE COMMUNICATION NETWORK

A method for connecting a user equipment to a network device via a mobile communication network wherein the equipment includes at least a deregistered and a registered state, the deregistered state including at least a normal and an attempting-to-attach substate, for defining a connectivity state of the equipment to the mobile communication network, the equipment being connectable to the mobile communication network and the network device being connected to the mobile communication network includes: 116234571123457123457623457. A method for connecting a user equipment () to a network device () via a mobile communication network ( , , , , ) , wherein the user equipment () comprises at least a deregistered state (B) and a registered state (C) , wherein the deregistered state (B) comprises at least two substates , a normal and an attempting-to-attach substate , for defining a connectivity state of the user equipment () to the mobile communication network ( , , , , ) , and wherein the user equipment () is connectable to the mobile communication network ( , , , , ) and wherein the network device () is connected to the mobile communication network ( , , , , )comprising the steps of{'b': '1', 'a) Paging of the user equipment () by a paging signal using a, preferably unique, user equipment identifier,'}{'b': '1', 'b) Switching to the attempting-to-attach substate of the deregistered state (B) of the user equipment () when receiving a paging signal,'}{'b': 1', '2', '3', '4', '5', '7, 'c) Attaching the user equipment () to the mobile communication network (, , , , ), and'}{'b': '1', 'd) Switching to the registered state (C) of the user equipment () depending on a result of the attachment according to step c)'}characterized in that{'b': 1', '1', '1', '1', '4', '2', '3', '4', '5', '7', '1', '1', '1', '1', '7', '2', '3', '4', '5', '7', '6, 'the user equipment () is formed such to provide a passive state (B) as connectivity state, wherein the user equipment () in the passive ...

HEART ASSISTANCE DEVICE

A heart assistance device for the pulsatile delivery of blood. A first and a second pump chamber are provided, and also a pump. Both pump chambers each have a fluid chamber and a blood-carrying chamber. By means of the pump, each fluid chamber can be filled with a fluid or emptied thereof in such a way that an expansion or contraction of the fluid chamber takes place. During the expansion of the fluid chamber of one pump chamber, a compression of the blood-carrying chamber of the same blood chamber takes place. 1. A heart assistance device for the pulsatile delivery of blood , comprisinga first and a second pump chamber, anda pump,each of the pump chambers comprising a fluid chamber and a blood-carrying chamber, and each fluid chamber being adapted to be filled with or emptied of a fluid by means of the pump such that an expansion or contraction of the fluid chamber occurs,the blood-carrying chamber of the same pump chamber is compressed upon the expansion of the fluid chamber of said respective pump chamber,whereinthe pump is designed as a roller cell pump or a vane pump.2. The heart assistance device of claim 1 , wherein the pump operates in a reversing mode.3. The heart assistance device of claim 1 , wherein the pump is operated in one direction claim 1 , the heart assistance device comprising valves for redirecting the fluid flow.4. The heart assistance device of claim 1 , wherein the heart assistance device comprises two roller cell or vane pumps claim 1 , each being connected with said respective fluid chamber and alternately delivering in opposed directions claim 1 , the quantity of fluid delivered into the fluid chambers being adjustable through the rotational speed of the first or the second roller cell or vane pump.5. The heart assistance device of claim 1 , comprising a housing claim 1 , wherein the two pump chambers and the pump are arranged in the housing and the pump is arranged between the pump chambers.6. The heart assistance device of claim 1 , ...

Herbicide triazolylpyridine ketones

Triazolylpyridine ketones expressed by the following formula (1) and use thereof as herbicides.

TYRE

Winter tyre includes a tread band on which a plurality of grooves, blocks and sipes of complex shape are provided, wherein the complex shape of the sipe is defined by a first protuberance having a vertex at a first depth from the tread surface. The vertex is connected to a sipe reference plane via a first connecting surface facing toward a radially outer side of the sipe and a second connecting surface facing toward a radially inner side of the sipe, the first connecting surface being inclined with respect to the plane of reference at an angle of between about 50° and about 90°, and the second connecting surface being inclined with respect to the plane of reference at an angle of between about 0° and about 50°. 132-. (canceled)33. A tyre comprising a tread band on which a plurality of grooves is provided; at least one block defined by said plurality of grooves; at least one sipe of complex shape provided on said at least one block defining a first and a second block portions separated from each other by said sipe , as well as a first and a second surfaces , respectively , on said first and second block portions , facing each other in a region of said sipe of complex shape , each of said first and second surfaces extending along a plane of reference incident to a tread surface radially external to said tread band , a longitudinal direction , substantially parallel with said tread surface , and a transverse direction substantially perpendicular to said longitudinal direction , being defined in said plane of reference , wherein on at least one of said first and second surfaces at least one first protuberance is provided , a projection of which in said transverse direction is at least partially superimposed on the projection in said transverse direction of the other of said first and second surfaces , and a vertex of which is positioned at a first depth from said tread surface measured in said transverse direction , said vertex being connected to said plane of reference ...

COATING FORMULATION FOR THE INTERIOR SURFACES OF CANS

The invention relates to a water-based can inner coating comprising a copolymer or a copolymer mixture of at least one aliphatic and acyclic alkene with at least one α,β-unsaturated carboxylic acid in water-dispersed form, wherein the acid number of the copolymer or of the copolymer mixture is at least 20 mg KOH/g, but not more than 200 mg KOH/g, and at least one water-dispersed or water-soluble curing agent. Inventive can inner coatings are characterized in that due to the good crosslinking of the copolymer or of the copolymer mixture with the curing agent, the cured film on the inner surfaces of metal cans possesses excellent properties in regard to hardness, abrasion resistance and resistance towards hot liquids. 1. A water-based can inner coating comprising , in addition to water ,a) a copolymer or a copolymer mixture of at least one aliphatic and acyclic alkene with at least one α,β-unsaturated carboxylic acid in water-dispersed form, wherein the acid number of the copolymer or of the copolymer mixture is at least 20 mg KOH/g, but not more than 200 mg KOH/g, andb) at least one water-dispersed or water-soluble curing agent selected from an aminoplast, a carbodiimide and combinations thereof.2. The water-based can inner coating according to claim 1 , wherein the acid groups of the copolymer or of the copolymer mixture in water-dispersed form are at least partially neutralized.3. The water-based can inner coating according to claim 2 , comprising a neutralization agent for neutralizing the acid groups of the copolymer or of the copolymer mixture in water-dispersed form claim 2 , said neutralization agent being selected from the group consisting of ammonia claim 2 , amines claim 2 , metallic Al claim 2 , metallic Zn claim 2 , water-soluble oxides of Li claim 2 , Na claim 2 , K claim 2 , Mg claim 2 , Ca claim 2 , Fe(II) claim 2 , Sn(II) claim 2 , water-soluble hydroxides of Li claim 2 , Na claim 2 , K claim 2 , Mg claim 2 , Ca claim 2 , Fe(II) claim 2 , Sn(II) and ...

Regenerative hydraulic shock-absorber for vehicle suspension

The shock-absorber comprises: a cylinder containing a hydraulic working fluid; a piston slidably arranged in the cylinder so as to split the cylinder into two variable-volume working chambers, namely a first working chamber, or extension chamber, and a second working chamber, or compression chamber; an auxiliary conduit in fluid communication on one side with the first working chamber and on the other with the second working chamber; a train of permanent magnets slidably arranged in the auxiliary conduit so as to reciprocally move along the auxiliary conduit, dragged by the working fluid flowing between the first and second working chambers through the auxiliary conduit as a result of the reciprocating motion of the piston in the cylinder; and electric energy generating device for generating electric energy by exploiting the movement of the train of permanent magnets along the auxiliary conduit.

Wearable robotic device for moving a user

A robotic device (100) for the movement of a user, said robotic device (100) comprising an interface frame (105) arranged to connect the robotic device (100) to a lower limbs or to a prosthesis of lower limbs, said interface frame (105) being integral to an axis x, a lower portion (110) integral to an axis y, a resilient element (140) having a first end (141) connected to the interface frame (105) and a second end (142) connected to the lower portion (110), said resilient element (140) being arranged to deform as a function of an angular variation θ between the axis x and the axis y, a switching device (120) comprising a first element (121), connected to the interface frame (105), and a second element (122), connected to the lower portion (110), said first and second element (121,122) arranged to carry out a relative movement s as a function of the angular variation θ between the axis x and the axis y. In particular, the robotic device (100) is configured in such a way that when the relative movement s is less than a predetermined threshold value s* and the angular variation θ increases, the robotic device (100) is in a first configuration and the resilient element (140) deforms storing elastic energy, said switching device (120) being configured in such a way that in the first configuration the relative movement s can take place only in one direction of motion, and that when the relative movements is equal to the predetermined threshold value s*, the robotic device (100) passes in a second configuration and the resilient element (140) releases elastic energy creating an angular moment Mel arranged to oppose the increasing of the angular variation θ.

Wearable active robot for body joints in series

The present concerns a wearable underactuated active robot with a couple of robotic joint adapted to correspond with to a couple of body joints in line on a limb of an user.

AUTHENTICATION DEVICE, NETWORK DEVICE, COMMUNICATION SYSTEM, AUTHENTICATION METHOD, AND NON-TRANSITORY COMPUTER READABLE MEDIUM

Provided is an authentication device capable of generating a master key suited to a UE in a 5GS. The authentication device () includes a communication unit () configured to, in registration processing of user equipment (UE), acquire UE key derivation function (KDF) capabilities indicating a pseudo random function supported by the UE, a selection unit () configured to select a pseudo random function used for generation of a master key related to the UE by use of the UE KDF capabilities, and a key generation unit () configured to generate a master key related to the UE by use of the selected pseudo random function. 1. An authentication device comprising:at least one memory storing instructions, andat least one processor configured to execute the instructions to;in registration processing of user equipment (UE), acquire UE key derivation function (KDF) capabilities indicating a pseudo random function supported by the UE;select a pseudo random function used for generation of a master key related to the UE by use of the UE KDF capabilities; andgenerate a master key related to the UE by use of the selected pseudo random function.2. The authentication device according to claim 1 , whereinthe at least one processor is further configured to execute the instructions to generate second authentication information by use of the master key, andsend the second authentication information to a network device.3. The authentication device according to claim 2 , wherein the second authentication information includes a session key used for communication with the UE connected to a non-3rd Generation Partnership Project (3GPP) access network or a 3GPP access network.4. The authentication device according to claim 1 , wherein the at least one processor is further configured to execute the instructions to generate the master key by use of first authentication information generated in a subscriber information management device and the selected pseudo random function.5. The authentication ...

DEDICATED CORE NETWORKS (DCN) SELECTION

The invention provides for a method of selecting a Dedicated Core Network (DCN) based on assisting indication by mobile terminals, and including the step of configuring the RAN Nodes of the mobile network with the DCN Types of the serving EPC Nodes so that the RAN Nodes can map the DCN selection assisting information from the connecting mobile terminals with the right dedicated EPC Node. This allows for the RAN Node to connect the mobile terminals with EPC Node of the mobile terminal's dedication at initial attach and then keep the mobile terminals on the same DCN. Thus, a re-routing of mobile terminals NAS message from one EPC Node to another EPC node is avoided. The invention also allows for a flexible and dynamic change of the EPC Nodes dedication based on operator's configuration and policy. Additionally, the invention allows for DCN access restriction control by broadcasting of the supported DCN Types by the RAN Node. 117-. (canceled)18. A radio access network node comprising:a first receiver configured to receive, from a core network node coupled to the radio access network node, a message for configuring with at least one network slice supported by the core network node, wherein the message includes first information for the at least one network slice;a second receiver configured to receive, from a mobile terminal which receives second information indicating the at least one network slice from the core network node, a Radio Resource Control (RRC) setup complete message including third information indicating a first network slice from among the at least one network slice;a memory storing instructions; andat least one processor configured to process the instructions to select a core network node specific for the first network slice based on the third information indicating the first network slice.19. A communication method in a radio access network node , comprising:receiving, from a core network node connected coupled to the radio access network node, a ...

COMMUNICATION TERMINAL, NETWORK DEVICE, COMMUNICATION METHOD, AND NON-TRANSITORY COMPUTER READABLE MEDIUM

A communication terminal () according to the present disclosure includes: a control unit () configured to, in a case of a movement from a communication area formed by the 5GS to a communication area formed by the EPS or a movement from a communication area formed by the EPS to a communication area formed by the 5GS, determine whether or not a communication system forming a communication area at a movement destination can satisfy requirements of services; and a communication unit () configured to, when it is determined that the communication system forming the communication area at the movement destination can satisfy the requirements of the services, send a connection request message to the communication system forming the communication area at the movement destination. 1. A communication terminal comprising:at least one memory; andat least one processor, comprising hardware, configured to:store a security context of the communication terminal, andderive, using the security context of the communication terminal, a security key to be used in a second communication system having a second network device in a case of a handover procedure from a first communication system having a first network device to the second communication system after the first network device checking whether access rights and security capabilities of the communication terminal are valid.2. The communication terminal according to claim 1 , whereinthe at least one processor is further configured to derive, using the derived security key, Non-Access Stratum (NAS) keys for integrity protection and encryption of a NAS message transmitted between the second network device and the communication terminal.3. The communication terminal according to claim 1 , whereinthe first communication system is a 5 generation system (5GS) and the second communication system is an evolved packet system (EPS), orthe first communication system is the EPS and the second communication system is the 5GS.46-. (canceled)7. A ...

METHOD OF INBOUND ROAMER DETECTION FOR NETWORKS SUPPORTING SERVICE DOMAIN CENTRALIZATION IN IMS

Embodiments of this disclosure enable the I-CSCF and S-CSCF to detect inbound roaming UEs to network supporting Service Domain Centralization in IMS, so that the S-CSCF is able to select the appropriate database entity and can understand the CS authentication vector. 18-. (canceled)9. An Interrogating Call Session Control Function (I-CSCF) entity , comprising:a receiver configured to receive a register message with an Internet Protocol (IP) Multimedia Private Identity (IMPI) of a User Equipment (UE) from a Mobile Switching Centre (MSC) server enhanced for Service Domain Centralization in IP Multimedia Subsystem (IMS) (SeDoC); and detect the UE is an inbound roaming UE, based on a comparison of a Mobile Network Code (MNC) and Mobile Country Code (MCC) included in the IMPI, and', 'query an IMS Centralized Services (ICS) Interworking Function (ICS-IWF) entity whether an operator network indicated by the MNC and MCC has an IMS roaming agreement, wherein, 'at least one processor configured to process to a further receiver configured to receive an address of a Serving Call Session Control Function (S-CSCF) entity which handles a Circuit Switched (CS) authentication procedure in a case that there is no IMS roaming agreement or a Service Level Agreement in place with a network including the I-CSCF entity; and', 'a transmitter configured to forward the register message with an indication that the register message is for inbound roaming UE, towards the S-CSCF entity., 'the I-CSCF entity further includes10. An Internet Protocol (IP) Multimedia Subsystem (IMS) Centralized Services (ICS) interworking Function (ICS-IWF) entity , comprising:a receiver configured to receive from an Interrogating Call Session Control Function (I-CSCF) entity, a query whether an operator network indicated by a MNC and MCC included in an IP Multimedia Private Identity (IMPI) with a registration message received by the I-CSCF entity has an IMS roaming agreement; and select a Serving Call Session ...

Suction Jet Pump

A suction jet pump has a fuel line, a propulsion jet nozzle, an intake region, a mixing tube and a diffuser. The propulsion jet nozzle and the mixing tube are oriented rectilinearly with respect to one another. As viewed in the direction of flow, the diffuser has a course which differs from the course of the mixing tube. 110.-. (canceled)11. A suction jet pump comprising:a propellant line;a propulsion jet nozzle fluidically downstream of the propellant line;a suction region;a mixing pipe arranged fluidically downstream of the suction region and orientated in a linear manner with respect to the propulsion jet nozzle; anda diffuser, wherein the diffuser, when viewed in a flow direction, has a path that deviates from a path of the mixing pipe.12. The suction jet pump as claimed in claim 11 , wherein the diffuser has a curved path.13. The suction jet pump as claimed in claim 11 , wherein a redirection element is arranged between the mixing pipe and the diffuser.14. The suction jet pump as claimed in claim 13 , wherein the redirection element has a redirection of less than 180° with respect to the path of the mixing pipe.15. The suction jet pump as claimed in claim 13 , wherein the redirection element has a redirection of 180° with respect to the path of the mixing pipe.16. The suction jet pump as claimed in claim 14 , wherein the redirection element is a separate component configured to connect the mixing pipe to the diffuser.17. The suction jet pump as claimed in claim 14 , wherein the redirection element is integrally formed with one of the mixing pipe and the diffuser.18. The suction jet pump as claimed in claim 14 , wherein the diffuser has a linear path.19. The suction jet pump as claimed in claim 14 , wherein the diffuser has a curved path.20. The suction jet pump as claimed in claim 11 , wherein the diffuser surrounds the mixing pipe in a coaxial manner.21. The suction jet pump as claimed in claim 15 , wherein the redirection element is a separate component ...

PRESSURE CONTROL BY PHASE CURRENT AND INITIAL ADJUSTMENT AT CAR LINE

A closed loop control system for a fuel pump based on characteristics of speed, pressure, and current. The pressure generated by the pump system is increased at the point in time when the pump system is working against a dead head system (i.e., coasting) to a level that a calibration valve is opened to a determined working point. By measuring the characteristic phase current as a function of the speed, the characteristic is able to be compared, with the pre-calibrated value of the hardware to perform an error compensation algorithm. The error compensation is overlaid with the standard pressure characteristic as a function of speed and phase current, and uses the pre-calibrated opening pressure value (i.e., the inflection point) of the calibration valve and/or in addition the change of the speed to the initial (first calibration), or to a sliding average therefrom. 1. An apparatus , comprising: a motor;', 'a device for generating a pumping action to transfer fluid, the device connected to and powered by the motor; and', 'a valve in fluid communication with the device;', 'wherein the device transfers the fluid at a selected pressure, and the selected pressure is based on the measured current applied to the motor, and the valve opens when the device pumps the fluid at a predetermined pressure, providing a calibration function., 'a pump system having a closed loop function, including2. The apparatus of claim 1 , further comprising:an inlet conduit in fluid communication with the motor, such that the fluid is transferred from the inlet conduit to the device as the motor powers the device;an outlet conduit in fluid communication with the device, such that the fluid flowing into the outlet conduit is pressurized by the device, and the pressure of the fluid in the outlet conduit is controlled by the device; anda secondary conduit in fluid communication with the outlet conduit;wherein the portion of the fluid in the secondary conduit is at substantially the same pressure as ...

DIKETOPIPERAZINE SALTS FOR DRUG DELIVERY AND RELATED METHODS

Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization. 2. The method of claim 1 , wherein said step for removing said solvent comprises distillation.3. The method of claim 1 , wherein said step for removing said solvent comprises evaporation.4. The method of claim 1 , wherein said step for removing said solvent comprises spray drying.5. The method of claim 1 , wherein said step for removing said solvent comprises lyophilization.6. The method of claim 1 , wherein Rand Rare independently selected from 4-succinyl-aminobutyl claim 1 , 4-glutaryl-aminobutyl claim 1 , 4-maleyl-aminobutyl claim 1 , 4-fumaryl-aminobutyl claim 1 , 4-citraconyl-aminobutyl claim 1 , 4-malonyl-aminobutyl claim 1 , 4-oxalyl-aminobutyl.7. The method of claim 1 , wherein said at least one cation is selected from the group consisting of sodium claim 1 , potassium claim 1 , calcium claim 1 , magnesium claim 1 , lithium claim 1 , triethylamine claim 1 , butylamine claim 1 , diethanolamine claim 1 , and triethanolamine.8. The method of claim 1 , wherein said at least one cation is sodium.9. The method of claim 1 , wherein said biologically active agent is selected from the group consisting of hormones claim 1 , anticoagulants claim 1 , immunomodulating agents claim 1 , cytotoxic agents claim 1 , antibiotics claim 1 , antivirals claim 1 , antisense claim 1 , anti-inflammatories claim 1 , vasoactive agents claim 1 , neuroactive agents claim 1 , cannabinoids claim 1 , antigens claim 1 , antibodies and active fragments and analogues thereof.10. The method of further comprising ...

APPARATUS, SYSTEM AND METHOD FOR MOBILE COMMUNICATION

In order for making MTC more efficient and/or secure, a base station forming a communication system connects a UE to a core network. A node serves as an entering point to the core network for a service provider, and transmits traffic between the service provider and the UE. The node establishes, as a connection to the base station, a first connection for directly transceiving messages between the node and the base station. Alternatively, the node establishes a second connection for transparently transceiving the messages through a different node that is placed within the core network and has established a different secure connection to the base station. 1. A first node in a mobile communication system including a UE (User Equipment) , a second node , and a server that is connected to the first node , the first node comprising:a processor; andmemory having stored thereon a set of instructions executable by the processor, wherein execution of the instructions by the processor causes the first node to:establish a connection between the first node and the second node by receiving, from the second node, a first message including information related to small dada so that the UE performs a mobile originated data transmission to the server,determine whether the first node releases the connection between the first node and the second node, andin response to determining whether the first node releases the connection between the first node and the second node, send a second message to the second node.2. The first node of claim 1 , wherein in roaming case claim 1 ,the first node is located in HPLMN (Home PLMN (Public Land Mobile Network)),a third node is located in VPLMN (Visited PLMN (Public Land Mobile Network)) for inter-connection with the first node, andthe third node connects to the second node.3. The first node of claim 1 , wherein the first node comprises an MTC-IWF (Machine-Type-Communication Inter-Working Function).4. The first node of claim 1 , wherein the second ...

VOICE SESSION HANDOVER

Apparatuses, methods, and systems are disclosed for voice session handover. One method () includes receiving () a handover message including first information indicating a voice handover request to handover a voice session from a first network to a second network. The method () includes determining () a first network function configured to facilitate communication with the second network. The method () includes transmitting () a relocation request message to the first network function, wherein the relocation request message includes second information related to the voice handover request. The method () includes receiving () a relocation response message from the first network function, wherein the relocation response message indicates completion of a voice handover. The method () includes transmitting () third information related to the voice handover to a third network function, wherein the third network function suspends non-guaranteed bit rate data flows. 1. A method comprising:receiving a handover message comprising first information indicating a voice handover request to handover a voice session from a first network to a second network;determining a first network function configured to facilitate communication with the second network;transmitting, to the first network function, a relocation request comprising second information related to the voice handover request; andreceiving, from the first network function, a relocation response indicating completion of a voice handover, wherein the first network comprises a different mobile network technology than the second network.2. (canceled)3. (canceled)4. An apparatus comprising:a receiver that receives a handover message comprising first information indicating a voice handover request to handover a voice session from a first network to a second network;a processor that determines a first network function configured to facilitate communication with the second network; anda transmitter that transmits, to the first ...

A METHOD AND A NETWORK STRUCTURE FOR PROVIDING DEVICE CONNECTIVITY TO A RADIO ACCESS NETWORK

A method for providing device connectivity to a radio access network, wherein at least two devices are connectable or connected to the radio access network and wherein the at least two devices are members of a group of devices within a wireless local network, the members of the group of devices having the capability to establish a direct connection with other members of the group of devices, includes providing connection information used for a connection between a first device of the at least two devices and the radio access network to a second device of the at least two devices. The connection information enables the second device to connect to the radio access network. 1. A method for providing device connectivity to a radio access network , wherein at least two devices are connectable or connected to the radio access network and wherein the at least two devices are members of a group of devices within a wireless local network , direct connection being establishable between the devices , the method comprising:providing, for a second device of the at least two devices, connection information useable for a connection between a first device of the at least two devices and the radio access network, so that the second device is enabled to connect to the radio access network based on the connection information.2. The method according to claim 1 , wherein the connection information comprises at least one of a connection parameter claim 1 , bearer parameter claim 1 , or a radio bearer parameter.3. The method according to claim 1 , wherein providing the connection information to the second device is performed based on at least one of finishing a data transmission from the first device to the radio access network or vice versa or a data transmission pause of a predetermined length.4. The method according to claim 1 , wherein the connection information is one or more of moved or transmitted from the first device to the second device or activated within the second device.5. ...

PRESSURE CONTROL BY PHASE CURRENT AND INITIAL ADJUSTMENT AT CAR LINE

A closed loop control system for a fuel pump based on characteristics of speed, pressure, and current. The pressure generated by the pump system is increased at the point in time when the pump system is working against a dead head system (i.e., coasting) to a level that a calibration valve is opened to a determined working point. By measuring the characteristic phase current as a function of the speed, the characteristic is able to be compared, with the pre-calibrated value of the hardware to perform an error compensation algorithm. The error compensation is overlaid with the standard pressure characteristic as a function of speed and phase current, and uses the pre-calibrated opening pressure value (i.e., the inflection point) of the calibration valve and/or in addition the change of the speed to the initial (first calibration), or to a sliding average therefrom. 1. An apparatus , comprising: a motor;', 'a device for generating a pumping action to transfer fluid, the device connected to and powered by the motor; and', 'a valve in fluid communication with the device;', 'wherein the device transfers the fluid at a selected pressure, and the selected pressure is based on the measured current applied to the motor, and the valve opens when the device pumps the fluid at a predetermined pressure, providing a calibration function., 'a pump system having a closed loop function, including2. The apparatus of claim 1 , further comprising:an inlet conduit in fluid communication with the motor, such that the fluid is transferred from the inlet conduit to the device as the motor powers the device;an outlet conduit in fluid communication with the device, such that the fluid flowing into the outlet conduit is pressurized by the device, and the pressure of the fluid in the outlet conduit is controlled by the device; anda secondary conduit in fluid communication with the outlet conduit;wherein the portion of the fluid in the secondary conduit is at substantially the same pressure as ...

SECURITY PROTECTION FOR USER PLANE TRAFFIC

Apparatuses, methods, and systems are disclosed for selective security protection of user plane traffic. One apparatus includes a transceiver that sends a UE security capability to a mobile communication network and receives an indication of data protection policy. The apparatus includes a processor that applies a security protection to a subset of user plane traffic with the mobile communication network according to the data protection policy. In such embodiments, a portion of the user plane traffic is communicated without the security protection. 1. An apparatus comprising: sends a UE security capability to a mobile communication network; and', 'receives an indication of data protection policy; and, 'a transceiver thata processor that applies a security protection to a subset of user plane traffic with the mobile communication network according to the data protection policy,wherein a portion of the user plane traffic is communicated without the security protection.2. The apparatus of claim 1 , wherein sending the UE security capability comprises transmitting the UE security capability in a registration request message.3. The apparatus of claim 1 , wherein the UE security capability indicates a UE Integrity Protection Maximum Data Rate for a data protection policy.4. The apparatus of claim 1 , wherein the data protection policy indicates one of: a sequence number range of packets to which security protection is to be applied claim 1 , a number of packets to which security protection is to be applied and a time period for which security protection is to be applied.5. The apparatus of claim 4 , wherein applying the security protection to the subset of user plane traffic comprises periodically applying the security protection at an interval indicated by the data protection policy.6. The apparatus of claim 1 , wherein applying the security protection to the subset of user plane traffic comprises applying asymmetric integrity protection to user plane traffic in either ...

USER EQUIPMENT, SYSTEM AND COMMUNICATION METHOD FOR MANAGING OVERLOAD IN THE CONTEXT OF CONTROL PLANE CELLULAR INTERNET OF THINGS EVOLVED PACKET SYSTEM OPTIMISATION

This disclosure provides a User Equipment (UE) (), including a receiver () and a controller (). The receiver () is configured to receive a control plane data back-off timer included in a Service Accept message from a network. The controller () is configured to consider a current data transfer via a control plane as successful based on the Service Accept message and not to initiate data transfer via Control Plane Cellular Internet of Things (CIoT) Evolved Packet System (EPS) Optimization while the control plane data back-off timer is running. 130-. (canceled)31. A UE (User Equipment) , comprising:a memory storing instructions; and receive a control plane data back-off timer included in a Service Accept message from a network, and', 'consider a current data transfer via a control plane as successful based on the Service Accept message and not to initiate data transfer via Control Plane CIoT (Cellular Internet of Things) EPS (Evolved Packet System) Optimization while the control plane data back-off timer is running., 'at least one processor configured to process the instructions to32. The UE according to claim 31 , wherein the at least one processor is further configured to process the instructions to:receive the control plane data back-off timer included in a Service Reject message from the network, andconsider the current data transfer via the control plane as unsuccessful based on the Service Reject message including a congestion cause and not to initiate data transfer via the Control Plane CIoT EPS Optimization while the control plane data back-off timer is running.33. The UE according to claim 31 , wherein the at least one processor is further configured to process the instructions to initiate user data transmission via the Control Plane CIoT EPS Optimization for at least one of high priority access claim 31 , emergency services and mobile terminated services while the control plane data back-off timer is running.34. The UE according to claim 31 , wherein the at ...

SECURITY CAPABILITIES IN AN ENCRYPTION KEY REQUEST

Apparatuses, methods, and systems are disclosed for security capabilities in an encryption key request. One method includes transmitting an encryption key request comprising security capabilities of a user equipment, wherein the encryption key request is for an application layer key. The method includes, in response to transmitting the encryption key request, receiving an encryption key response comprising a group encryption key. 1. A method comprising:transmitting an encryption key request as part of a non-access stratum request comprising security capabilities of a user equipment, wherein the encryption key request is for an application layer key; andin response to transmitting the encryption key request as part of a non-access stratum response, receiving an encryption key response comprising a group encryption key.2. The method of claim 1 , wherein the encryption key request is transmitted from the user equipment to an application management function device or a policy control function device.3. The method of claim 1 , wherein the encryption key response is received by the user equipment from an application management function device or a policy control function device.4. The method of claim 1 , wherein the encryption key request is transmitted from an application management function device or a policy control function device to a unified data device or a key management server.5. The method of claim 1 , wherein the encryption key response is received by an application management function device or a policy control function device from a unified data device or a key management server.6. The method of claim 1 , wherein the encryption key request is transmitted from a unified data device to a key management server.7. The method of claim 1 , wherein the encryption key response is received by a unified data device from a key management server.8. The method of claim 1 , wherein the encryption key response comprises a key identifier or an expiration time.9. An apparatus ...

Geostationary floating platform

A system is demonstrated for heave neutralisation of semisubmersible platforms that can be built into any conceivable configuration of such platforms. That the system is also conceivably active and predicatively can be controlled can be concluded by analysing the appended calculation models. As an example FIG. 18 , column E, is mentioned, wherein the water volume increments in the rise canister are 37 cubic metres for each half metre of wave height, so that, with reference to column A, from H=10.5 m to H=12 m is 4×37 148 cubic metres more than 150 tonnes—simultaneously with the air pressure, shown in column K, increasing from 123.86 to 131.05 kPa, a difference of just 6.19 kPa (0.0619 bar or 61.9 millibars). Large ballast volumes can be moved out and in of the system at small pressure changes and short response time.

INDICATING RADIO CAPABILITY CHANGES IN AN INACTIVE STATE

Apparatuses, methods, and systems are disclosed for indicating radio capability changes in an inactive state. One method includes detecting a trigger to change radio capabilities of a UE in an inactive state; transmitting a first message comprising information indicating to change the radio capabilities of the UE, wherein the first message comprises a first access stratum message; receiving a second message, wherein the second message comprises information corresponding to an action, and the second message comprises a second access stratum message; receiving a third message comprising information requesting the radio capabilities of the UE; transmitting a fourth message comprising the radio capabilities of the UE; and receiving a fifth message comprising information for configuring a radio resource control of the UE and activating data radio bearers of the UE, wherein the fifth message is determined based on the radio capabilities of the UE. 1. A method comprising:detecting a trigger to change radio capabilities of a user equipment in an inactive state;transmitting a first message comprising information indicating to change the radio capabilities of the user equipment, wherein the first message comprises a first access stratum message;receiving a second message in response to transmitting the first message, wherein the second message comprises information corresponding to an action, and the second message comprises a second access stratum message;receiving a third message comprising information requesting the radio capabilities of the user equipment;transmitting a fourth message comprising the radio capabilities of the user equipment; andreceiving a fifth message comprising information for configuring a radio resource control of the user equipment and activating data radio bearers of the user equipment, wherein the fifth message is determined based on the radio capabilities of the user equipment.2. The method of claim 1 , wherein the first message comprises a radio ...

ANTIBODY DIRECTED AGAINST S. AUREUS CLUMPING FACTOR A (ClfA)

The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating a Staphylococcus aureus infection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds to S. aureus alpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.

METHOD AND APPARATUS FOR ATTACH PROCEDURE WITH SECURITY KEY EXCHANGE FOR RESTRICTED SERVICES FOR UNAUTHENTICATED USER EQUIPMENT

A method and apparatus provide for security for restricted local operator services. At least one of a restricted local operator services indication and security capabilities associated with the restricted local operator services can be sent. A non-access stratum key exchange request including a symmetric root key can be received. The symmetric root key can be encrypted with a public key. The non-access stratum key exchange request can be acknowledged. A non-access stratum security key can be derived with the symmetric root key. Radio interface keys for user plane and radio resource control can be derived with the symmetric root key. 1. A method , comprising:sending at least one of a restricted local operator services indication and security capabilities associated with the restricted local operator services;receiving a non-access stratum key exchange request including a symmetric root key, the symmetric root key being encrypted with a public key;{'sub': ';', 'acknowledging the non-access stratum key exchange request'}deriving a non-access stratum security key with the symmetric root key; andderiving radio interface keys for user plane and radio resource control with the symmetric root key.2. The method according to claim 1 , wherein the method is implemented by a user equipment.3. The method according to claim 1 , wherein the public key is a first public key claim 1 , the method further comprising:receiving a broadcast system information message, the broadcast system information including the first public key; andsending a non-access stratum request message including at least one of the security capabilities associated with restricted local operator services and a second public key.4. The method according to claim 3 , further comprising encrypting the second public key with the first public key.5. The method according to claim 1 , wherein the public key is a first public key claim 1 , the method further comprising:receiving the first public key in a first non-access ...

METHOD AND APPARATUS FOR DISCOVERY AND ACCESS OF RESTRICTED LOCAL SERVICES FOR UNAUTHENTICATED UES

A determination can be made as to whether a mobile equipment has valid credentials for accessing an available public land mobile network. Availability of restricted operator services access support can be detected. A cell of a public land mobile network that supports restricted operator services access can be selected as a serving cell if restricted operator services access support is available and the mobile equipment does not have valid credentials for accessing the available public land mobile network. An attach procedure can be performed for restricted operator services using the public land mobile network of the selected cell as a selected public land mobile network. 1. A method comprising:determining, at a mobile equipment, whether the mobile equipment has valid credentials for accessing an available public land mobile network;detecting restricted operator services access support is available;selecting a cell of a public land mobile network that supports restricted operator services access as a serving cell if restricted operator services access support is available and the mobile equipment does not have valid credentials for accessing the available public land mobile network; andperforming an attach procedure for restricted operator services using the public land mobile network of the selected cell as a selected public land mobile network.2. The method according to claim 1 , further comprising receiving a broadcasted system information message including a restricted operator services access indication from a network entity of the public land mobile network claim 1 , the restricted operator services access indication indicating the public land mobile network supports restricted operator services access claim 1 ,wherein detecting restricted operator services access support is available comprises detecting restricted operator services access support on the public land mobile network is available based on the broadcasted system information message including the ...

METHOD AND APPARATUS FOR SHORT CODE DIALING FOR RESTRICTED SERVICES FOR UNAUTHENTICATED USER EQUIPMENT

A method and apparatus provide for attachment for restricted local operator services for an apparatus, such as a user equipment. An attach procedure for the restricted local operator services for the apparatus can be performed. A proxy call session control function address for the restricted local operator services can be received during the attach procedure. A session initiation protocol register request message can be generated. The session initiation protocol register request message can include an indication for the restricted local operator services and can include an internet protocol multimedia public user identification based on an identification of the apparatus. The session initiation protocol register request message to the proxy call session control function address can be sent, the session initiation protocol register request message can include the indication for the restricted local operator services. 1. A method , comprising:performing an attach procedure for restricted local operator services for an apparatus;receiving during the attach procedure a proxy call session control function address for the restricted local operator services;generating session initiation protocol register request message, the session initiation protocol register request message including an indication for the restricted local operator services and including an internet protocol multimedia public user identification based on an identification of the apparatus;sending the session initiation protocol register request message to the proxy call session control function address; andreceiving a response message indicating the apparatus is registered with the restricted local operator services of an internet protocol multimedia core network subsystem.2. The method according to claim 1 , further comprising sending a session initiation protocol invite request message to a network entity based on an acceptance of the session initiation protocol register request message.3. The method ...

NETWORK SLICE AUTHENTICATION

Apparatuses, methods, and systems are disclosed for network slice authentication. One apparatus includes a processor that provides an application layer and a non-access stratum (“NAS”) layer and a transceiver for communicating with a mobile communication network. The processor receives, at an application at the application layer, network slice authentication information for a subscribed service and stores the network slice authentication information at an application module. The processor associates the network slice authentication information with single network slice selection assistance information (“S-NSSAI”) and registers the application with the NAS layer, said registration pointing to the associated S-NSSAI. Additionally, the transceiver that exchanges, via the NAS layer, authentication messages with an authentication, authorization, and accounting (“AAA”) server for network slice authentication information. 1. An apparatus comprising: receives, at an application at the application layer, network slice authentication information for a subscribed service;', 'stores the network slice authentication information at an application module;', 'associates the network slice authentication information with single network slice selection assistance information (“S-NSSAI”); and', 'registers the application with the NAS layer, said registration pointing to the associated S-NSSAI; and, 'a processor that provides an application layer and a non-access stratum (“NAS”) layer, wherein the processor furthera transceiver that exchanges, via the NAS layer, authentication messages with an authentication, authorization, and accounting (“AAA”) server for network slice authentication information.2. The apparatus of claim 1 , wherein the network slice authentication information includes one or more of: an indication whether authentication is required claim 1 , a user ID claim 1 , a service ID claim 1 , a service description claim 1 , an AAA server ID claim 1 , and security credentials. ...

TRANSPORT LAYER PROTOCOL FOR SIP MESSAGE

Apparatuses, methods, and systems are disclosed for selecting a transport layer protocol for SIP messaging. One apparatus includes a processor and a transceiver that receives a SIP message from a remote unit, the SIP message comprising a first request to initiate a session for an IMS MMTEL. The processor determines that the SIP message is communicated using TCP as a transport layer protocol and forwards the first request to a network entity, wherein the first request is sent using UDP as the transport layer protocol. 1. An apparatus comprising:a transceiver that receives a session initiation protocol (“SIP”) message from a remote unit, the SIP message comprising a first request to initiate a session for an Internet Protocol Multimedia Subsystem (“IMS”) Multimedia Telephony Communication Service (“MMTEL”); anda processor that:determines that the SIP message is communicated using transmission control protocol (“TCP”) as a transport layer protocol; andforwards the first request to a network entity, wherein the first request is sent using user datagram protocol (“UDP”) as the transport layer protocol.2. The apparatus of claim 1 , wherein the processor identifies the network entity in response to the SIP message and determines a transport protocol for communication with the network entity claim 1 , wherein the first request is forwarded using UDP in response to the determination.3. The apparatus of claim 2 , wherein the determination is made based on one or more of: the identity of the network entity claim 2 , a transport protocol type used to communicate the SIP message claim 2 , a message type of the SIP message claim 2 , and a transport protocol preference from the remote unit.4. The apparatus of claim 1 , wherein the transceiver receives a transport protocol preference from the remote unit claim 1 , wherein the transport protocol preference indicates TCP as the protocol for reception of SIP messages transmitted to the remote unit.5. The apparatus of claim 4 , wherein ...

APPARATUS, SYSTEM AND METHOD FOR MOBILE COMMUNICATION

In order for making MTC more efficient and/or secure, a base station forming a communication system connects a UE to a core network. A node serves as an entering point to the core network for a service provider, and transmits traffic between the service provider and the UE. The node establishes, as a connection to the base station, a first connection for directly transceiving messages between the node and the base station. Alternatively, the node establishes a second connection for transparently transceiving the messages through a different node that is placed within the core network and has established a different secure connection to the base station. 1. A mobile communication system , comprising:a UE (User Equipment) that attaches to an MME (Mobility Management Entity) or an SGSN (Serving GPRS Support Node); anda first node that establishes a secure connection, receives data from the UE via the MME or the SGSN using the secure connection, determines a release of the secure connection, and sends a release connection message to the MME or the SGSN,wherein the MME or the SGSN deletes information on the data.2. A first node in a mobile communication , comprising:a controller configured to establish a secure connection;a receiver configured to receive data from a UE (User Equipment), which attaches to an MME (Mobility Management Entity) or an SGSN (Serving GPRS Support Node), via the MME or the SGSN using the secure connection; anda sender configured to determine a release of the secure connection and send a release connection message to the MME or the SGSN,wherein the MME or the SGSN deletes information on the data.3. A UE (User Equipment) in a mobile communication , comprising:a controller to attach to an MME (Mobility Management Entity) or an SGSN (Serving GPRS Support Node); anda sender configured to send data to a first node, which establishes a secure connection, via the MME or the SGSN using the secure connection,wherein the first node determines a release of ...

METHOD, USER EQUIPMENT, MASTER EVOLVED NODE B AND COMMUNICATION SYSTEM FOR DUAL CONNECTIVITY

A method for dual connectivity (DC) performed by a user equipment (UE), wherein said the UE is in connected mode and is connected to a master evolved node B (MeNB) and connectable to a secondary evolved node B (SeNB), includes informing a communication system entity about regarding DC support of said the UE, and when the UE supports DC, receiving a connection reconfiguration message to change or split bearers from the MeNB to the SeNB. 1. A method for dual connectivity , ‘DC’ , performed by a user equipment , ‘UE’ , wherein said UE is in connected mode and is connected to a master evolved node B , ‘MeNB’ , and connectable to a secondary evolved node B , ‘SeNB’ ,the method comprising:informing a communication system entity about DC support of said UE, andwhen the UE supports DC, receiving a connection reconfiguration message to change or split bearers from the MeNB to the SeNB.2. The method according to claim 1 , wherein said connection reconfiguration message comprises a new radio resource configuration for DC with the SeNB.3. The method according to claim 1 , wherein said communication system entity is either the MeNB or a mobility management entity claim 1 , ‘MME’.4. A method for dual connectivity claim 1 , ‘DC’ claim 1 , performed by a master evolved node B claim 1 , ‘MeNB’ claim 1 , in a communication system including a user equipment claim 1 , ‘UE’ claim 1 , wherein said UE is in connected mode and is connected to said MeNB and connectable to a secondary evolved node B claim 1 , ‘SeNB’ claim 1 ,the method comprising:receiving information about DC support of said UE; andproviding, to said UE, a connection reconfiguration message to change or split bearers from the MeNB to the SeNB, when said UE supports DC.5. The method according to claim 4 , wherein said MeNB decides to configure said UE for DC.6. The method according to claim 5 , wherein said decision is based on properties of current bearers of said UE.7. The method according to claim 4 , wherein said ...

A method for characterizing melanocytic lesions

The present disclosure pertains to the identification of novel biomarkers for the characterization of melanocytic lesions as can be found in skin diseases such as melanomas and psoriasis. In particular, the present invention is directed to a method for characterizing melanocytic lesions and their use in an automated or semi-automated device for the diagnosis and/or monitoring of benign, pre-malignant, and malignant melanocytic lesions, as further defined in the claims.

APPARATUS, SYSTEM AND METHOD FOR MOBILE COMMUNICATION

In order for making MTC more efficient and/or secure, a base station forming a communication system connects a UE to a core network. A node serves as an entering point to the core network for a service provider, and transmits traffic between the service provider and the UE. The node establishes, as a connection to the base station, a first connection for directly transceiving messages between the node and the base station. Alternatively, the node establishes a second connection for transparently transceiving the messages through a different node that is placed within the core network and has established a different secure connection to the base station. 1. A mobile communication system , comprising:a UE (User Equipment) that attaches to an MME (Mobility Management Entity) or an SGSN (Serving GPRS Support Node); anda first node that establishes a secure connection, sends data to the UE via the MME or the SGSN using the secure connection, determines a release of the secure connection, and sends a release connection message to the MME or the SGSN,wherein the MME or the SGSN deletes information on the data.2. A first node in a mobile communication system , comprising:a controller configured to establish a secure connection; anda sender configured to send data to a UE (User Equipment), which attaches to an MME (Mobility Management Entity) or an SGSN (Serving GPRS Support Node), via the MME or the SGSN using the secure connection, determine a release of the secure connection, and send a release connection message to the MME or the SGSN,wherein the MME or the SGSN deletes information on the data.3. A UE (User Equipment) in a mobile communication system , comprising:a controller to attach to an MME (Mobility Management Entity) or an SGSN (Serving GPRS Support Node); anda receiver configured to receive data from a first node, which establishes a secure connection, via the MME or the SGSN using the secure connection,wherein the first node determines a release of the secure ...

COMMUNICATION SYSTEM

A communication system is disclosed in which a base station receives, from a communication device, NAS signalling for establishing a connection via the base station. The base station forwards the NAS signalling to a default MME for setting up the connection to the default MME. The default MME sends, responsive to the base station forwarding the NAS said signalling, a message identifying an MME group to which the NAS signalling should be rerouted. The base station selects an MME based an the message identifying the MME group, and forwards the NAS signalling to the selected MME, and includes information indicating that the NAS signalling shall not be rerouted. 119-. (canceled)20. A communication method of a radio access network node in a wireless communication system , the communication method comprising:receiving, from a communication device, a first message for establishing a communication connection;sending the first message to a first core network node;receiving, from the first core network node, a second message including information identifying a group of at least one core network node;selecting a second core network node based on the second message; andsending a third message including the first message to the second core network node, andwherein the third message includes information indicating that the first message shall not be rerouted.21. The communication method according to claim 20 , wherein the group comprises a dedicated core network of at least one core network node claim 20 , the dedicated core network corresponding to a type of the communication device that sends the first message.22. The communication method according to claim 20 , wherein the selecting the second core network node is performed based on at least one of:a Mobility Management Entity (MME) group identifier (MMEGI);a network resource identifier (NRI);a Serving General packet radio service Support Node (SGSN) group identifier; anda globally unique temporary identifier (GUTI), included ...

System and method for executing straight tracking control of a work vehicle

A method for executing straight tracking control may include receiving an input command(s) associated with controlling the operation of a first-side drive system and/or a second-side drive system of a hydrostatic transmission of a work vehicle to drive the vehicle along a straight path. The method may also include receiving first and second speed signals associated with the output speeds of the drive systems, and modifying the first speed signal or the second speed signal based on a speed scaling factor to generate a corrected speed signal. In addition, the method may include determining an adjusted control command for controlling the operation of the hydrostatic transmission as a function of the input command(s) and a control output determined based on the corrected speed signal. Further, the method may include controlling the operation of the hydrostatic transmission based at least in part on the adjusted control command.

COMMUNICATION SYSTEM

A communication system is disclosed in which a home subscriber server, ‘HSS’, of a communication network, receives, from a service capability exposure function, ‘SCEF’, at least one communication pattern parameter set together with an associated validity time, stores the at least one communication pattern parameter set, and when the validity time for a communication pattern parameter set stored in the HSS expires, autonomously deletes the associated communication pattern parameter set. 1. A home subscriber server , ‘HSS’ , for a communication network , the HSS comprising:a receiver circuit configured to receive, from a service capability exposure function, ‘SCEF’, at least one communication pattern parameter set together with an associated validity time wherein the validity time indicates when the communication pattern parameter set expires; anda processor configured:to store the at least one communication pattern parameter set; andwhen the validity time for a communication pattern parameter set stored in the HSS expires, to autonomously delete the associated communication pattern parameter set.2. The home subscriber server of further comprising a transmitter circuit configured to provide claim 1 , to a mobility management entity claim 1 , ‘MME’ claim 1 , at least one set of parameters associated with the communication pattern together with an associated validity time.3. The home subscriber server of wherein the transmitter circuit provides the at least one set of parameters associated with the communication pattern in subscription protocol information.4. The home subscriber server of wherein the at least one communication pattern parameter set received claim 1 , together with an associated validity time claim 1 , from the SCEF claim 1 , is received together with an SCEF Reference ID.5. A mobility management entity claim 1 , ‘MME’ for a communication network claim 1 , the MME comprising:a receiver circuit configured to receive, from a home subscriber server, ‘HSS’, ...

INDICATING A NETWORK FOR A REMOTE UNIT

Apparatuses, methods, and systems are disclosed for indicating a network for a remote unit. One method includes transmitting a first message including a first registration request from a remote unit. The method includes receiving a second message including a first indication of a network to which the remote unit belongs. The second message is received in response to transmitting the first message. The method includes transmitting a third message including a second registration request from the remote unit. The second registration request includes a second indication of the network to which the remote unit belongs, and the second indication is based on the first indication. 1. A method of a radio access network node of a network , the method comprising:transmitting information indicating whether the network supports an access procedure for providing a user equipment with credentials;in response to transmitting information indicating that the network supports the access procedure, receiving a request message from the user equipment for initiation of the access procedure; andinitiating the access procedure.2. The method of claim 1 , wherein the information is broadcasted.3. The method of claim 1 , wherein the information is broadcasted in a system information block or a master information block.4. The method of claim 1 , wherein the information is used in the user equipment for a network selection procedure.5. The method of claim 1 , wherein the access procedure comprises a network selection procedure and a registration procedure.6. The method of claim 5 , wherein the registration procedure comprises a restricted registration procedure for an internet of things user equipment.7. The method of claim 1 , wherein the access procedure comprises an onboarding procedure.8. An apparatus comprising a radio access network node of a network claim 1 , the apparatus further comprising:a transmitter that transmits information indicating whether the network supports an access ...

FAST-ACTING PLANT-BASED MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS

Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.

INTEGRITY PROTECTION FOR A PACKET DATA UNIT

Apparatuses, methods, and systems are disclosed for integrity protection for a packet data unit. One method includes determining a first portion of a packet data unit, wherein the packet data unit includes the first portion and a second portion. The method includes applying an integrity protection function to the first portion of the packet data unit to result in an integrity protection indicator without applying the integrity protection function to the second portion of the packet data unit. The method includes transmitting the packet data unit with the integrity protection indicator. 1. A method comprising:determining a first portion of a packet data unit, wherein the packet data unit comprises the first portion and a second portion;applying an integrity protection function to the first portion of the packet data unit to result in an integrity protection indicator without applying the integrity protection function to the second portion of the packet data unit; andtransmitting the packet data unit with the integrity protection indicator.2. The method of claim 1 , further comprising receiving information indicating a length of the portion of the packet data unit.3. The method of claim 2 , wherein the information indicating the length is received as part of a packet data convergence protocol configuration via a radio resource control message.4. The method of claim 2 , wherein the length of the portion of the packet data unit is determined based on a user equipment capability corresponding to integrity protection.5. The method of claim 1 , further comprising receiving information indicating a location of the portion of the packet data unit within the packet data unit.6. The method of claim 5 , wherein the information indicating the location comprises an offset.7. The method of claim 1 , further comprising transmitting information indicating a length of the portion of the packet data unit.8. The method of claim 7 , further comprising transmitting information indicating ...

Fuel-Conveying System For Use In A Vehicle

A fuel-conveying system includes: a primary fuel pump, configured to supply fuel to an internal combustion engine of a vehicle, at a fuel pressure; a suction jet pump configured to convey fuel from a first region of a fuel tank of the vehicle to a second region of the fuel tank, the at least one suction jet pump having a nozzle; and a secondary fuel pump, decoupled from the primary fuel pump and configured to: supply, as required, the suction jet pump with a fuel jet, and set, independently of the primary fuel pump, a pressure of the fuel jet before the nozzle of the suction jet pump. 114-. (canceled)15444ab. A fuel-conveying system for use in a vehicle having an internal combustion engine and a fuel tank () having a first region () and a second region () , the fuel-conveying system comprising:{'b': '10', 'at least one primary fuel pump (), configured to supply fuel to the internal combustion engine, at a fuel pressure;'}{'b': 14', '16', '4', '4', '4', '4', '14', '16', '15', '17, 'i': a', 'b, 'at least one suction jet pump (, ) configured to convey the fuel from the first region () of the fuel tank () to the second region () of the fuel tank (), the at least one suction jet pump (, ) having a nozzle (, ); and'}{'b': 12', '10, 'claim-text': [{'b': 14', '16, 'supply, as required, the at least one suction jet pump (, ) with a fuel jet, and'}, {'b': 10', '15', '17', '14', '16, 'set, independently of the at least one primary fuel pump (), a pressure of the fuel jet before the nozzle (, ) of the at least one suction jet pump (, ).'}], 'at least one secondary fuel pump (), decoupled from the at least one primary fuel pump () and configured to16122812101210. The system as claimed in claim 15 , further comprising claim 15 , downstream of the at least one secondary fuel pump () claim 15 , a check valve () configured to decouple a hydraulic conveying circuit of the at least one secondary fuel pump () from a conveying path of the at least one primary fuel pump () and via which ...

RAPID AND CONTROLLED DELIVERY OF COMPOSITIONS WITH RESTORED ENTOURAGE EFFECTS

Fast-acting oral formulations with restored entourage effects are described. The formulations include beneficial combinations of plant-derived molecules to provide restored entourage effects, and one or more carriers. The carriers can include N-acylated fatty amino acids, absorption enhancers, and/or various other beneficial carriers. The fast-acting oral formulations can create administration benefits. 1. A fast-acting oral formulation comprising:(i) a cannabinoid comprising THC and/or CBD,(ii) an entourage-restoring molecule, and(iii) N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC), wherein the cannabinoid and the entourage-restoring molecule are at a ratio of 1000:1, 500:1, 200:1, 100:1, 50:1, 20:0, 10:1, 1:1, 0.2:1, or 0.1:1, andwherein the cannabinoid and the SNAC are at a ratio of between 1:1 and 100:1.2. The fast-acting oral formulation of comprising THC and CBD.3. The fast-acting oral formulation of wherein the ratio of THC:CBD is between 0.01:1 and 100:1.4. The fast-acting oral formulation of wherein the entourage-restoring molecule is selected from: an additional cannabinoid claim 1 , a terpene claim 1 , a flavonoid claim 1 , and an aroma- and flavor-conferring volatile.5. The fast-acting oral formulation of wherein the additional cannabinoid is selected from: Δ8-tetrahydrocannabinol (Δ8-THC) claim 4 , Δ11-tetrahydrocannabinol (Δ11-THC) claim 4 , cannabigerol (CBG) claim 4 , cannabichromene (CBC) claim 4 , cannabinol (CBN) claim 4 , cannabinodiol (CBDL) claim 4 , cannabicyclol (CBL) claim 4 , cannabivarin (CBV) claim 4 , tetrahydrocannabivarin (THCV) claim 4 , cannabidivarin (CBDV) claim 4 , cannabichromevarin (CBCV) claim 4 , cannabigerovarin (CBGV) claim 4 , cannabigerol monomethyl ether (CBGM) claim 4 , cannabinerolic acid claim 4 , cannabidiolic acid (CBDA) claim 4 , Cannabinol propyl variant (CBNV) claim 4 , cannabitriol (CBO) claim 4 , tetrahydrocannabinolic acid (THCA) claim 4 , and tetrahydrocannabivarinic acid (THCVA).6. The fast-acting oral ...

METHOD FOR MANAGING OVERLOAD IN A MOBILE COMMUNICATION NETWORK

A mobile communication network (MCN) and method for managing (overload in) an MCN having a radio access network and core network connected to the radio access network, wherein a plurality of user devices in form of non-MTC user devices like mobile phones and MTC user devices is connected to base station(s) of the radio access network, includes: a) detecting a presence of a network overload in the MCN, b) generating an overload report according to the detected network overload comprising one or more resource identifiers of the resources of the MCN on which the overload was detected, e) identifying (WI) user device(s) (UD) and/or application(s) affected by the network overload (OL) based on the overload report, and d) informing one or more serving entities serving the resolved UD for temporarily suppressing communication requests, preferably in form of devices triggers (DT), for the resolved UD, preferably MTC UD. 1. A method for managing overload in a mobile communication network including a radio access network and a core network connected to the radio access network , wherein a plurality of non-MTC user devices and/or MTC user devices is connected to one or more base stations of the radio access network , the method comprising:a) detecting a presence of a network overload in the mobile communication network;b) generating an overload report according to the detected network overload having one or more resource identifiers of the resources of the mobile communication network on which the network overload was detected;c) identifying one or more user devices and/or applications affected by the network overload based on the overload report; andd) informing one or more serving entities serving resolved user devices for temporarily suppressing communication requests.2. The method of claim 1 , further comprising:storing suppressed communication requests until network overload is resolved.3. The method of claim 1 , further comprising:generating one or more rules for an ...

KEY DERIVATION METHOD, COMMUNICATION SYSTEM, COMMUNICATION TERMINAL, AND COMMUNICATION DEVICE

An object is to provide a key generation method capable of maintaining a high security level in each of sliced networks when network slicing is applied to a core network. A key generation method according to this disclosure specifies network slice identification information indicating a network slice system that provides a service to be used by a communication terminal () among a plurality of network slice systems included in a core network () and, using the network slice identification information, generates a service key to be used for security processing in the network slice system indicated by the network slice identification information. 1. (canceled)2. A key derivation method in a communication terminal that communicates with a core network , the key derivation method comprising:deriving a key for each of a plurality of network slices included in the core network.3. The key derivation method according to claim 1 , further comprising:deriving a common key common to the plurality of network slices.4. The key derivation method according to claim 3 , wherein both the key for each of the plurality of network slices and the common key are derived from one master key.5. The key derivation method according to claim 3 , wherein the common key is for a control plane.6. The key derivation method according to claim 3 , wherein a key for integrity assurance processing and a key for encryption processing are derived from the common key.7. The key derivation method according to claim 2 , wherein the key for each of the plurality of network slices is for a user plane.8. The key derivation method according to claim 2 , wherein a key for integrity assurance processing and a key for encryption processing are derived from the key for each of the plurality of network slices.9. A communication system comprising:a core network including a plurality of network slices; anda communication device,wherein the communication device derives a key for each of the plurality of network slices. ...

Diketopiperazine salts for drug delivery and related methods

Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization. 2. The method of claim 1 , wherein said PDE5 inhibitor is selected from the group consisting of sildenafil citrate claim 1 , vardenafil hydrochloride and tadalafil.3. The method of claim 1 , wherein said PDE5 inhibitor is tadalafil.4. The method of claim 1 , wherein said cation is selected from the group consisting of sodium claim 1 , potassium claim 1 , calcium claim 1 , lithium claim 1 , triethylamine claim 1 , butylamine claim 1 , diethanolamine and triethanolamine.5. The method of claim 1 , wherein said cation is sodium.6. The method of claim 1 , wherein the dry powder is formed by the removal of a solvent from a solution containing the PDE5 inhibitor claim 1 , the pharmaceutically acceptable salt of the heterocyclic compound claim 1 , and the cation.7. The method of claim 6 , wherein the removal of the solvent is achieved by spray drying.8. The method of claim 6 , wherein the removal of the solvent is achieved by evaporation.9. The method of claim 6 , wherein the removal of the solvent is achieved by lyophilization.10. The method of claim 6 , wherein the dry powder is prepared by a method that includes micronizing a solid to form microparticles of the dry powder.11. The method of claim 10 , wherein the microparticles of the dry powder are suitable for pulmonary delivery.12. The method of claim 10 , wherein the microparticles of the dry powder have a rugosity of less than 2.13. The method of claim 10 , wherein at least 50% of the microparticles have a diameter less than 5 μm.14. ...

Eyewear with parametric audio unit

Eyewear for outputting audio information to the wearer include an eyewear temple, which has at least one loudspeaker. The eyewear temple is configured for placement on an ear of the wearer and spaced apart from an ear opening of the wearer's ear so that the sound waves generated by the loudspeaker are transmitted over the surroundings to the spaced ear opening. The loudspeaker is an ultrasonic loudspeaker. The eyewear has a parametric audio unit that includes the ultrasonic loudspeaker and configured to generate an audible sound beam directed at the ear.

FAST-ACTING PLANT-BASED MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS

Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits. 1. A fast-acting plant-based composition formulated for oral delivery comprising (i) THC and/or CBD and (ii) N-[8-(2-hydroxybenzoyl) amino] caprylate.2. A fast-acting plant-based composition formulated for oral delivery comprising (i) vegetable matter with an aqueous solubility of less than 0.1 mg/ml and (ii) N-[8-(2-hydroxybenzoyl) amino] caprylate.3. A plant-based composition comprising vegetable matter and an N-acylated fatty amino acid or a salt thereof.4. A plant-based composition comprising a botanical product and an N-acylated fatty amino acid or a salt thereof.5Calophyllum brasiliense, Calophyllum caledonicum, Calophyllum inophyllum, Calophyllum soulattri, Uncaria tomentosa, Thymus vulgaris, Matricaria recutita, Salix alba, Calendula officinalis, Usnea barbata, Ligusticum porteriiosha, Gaultheria procumbens, Camellia sinensis, Vaccinium myrtillus, Melissa officinalis, Allium sativum, Camellia sinensis, Krameria triandra, Punica granatum, Viburnum plicatum, Nicotiana tabacum, Duboisia hopwoodii, Asclepias syriaca, Curcuma longa, Cannabis sativa, Cannabis indica, Cannabis ruderalisAcer. A plant-based composition of wherein the vegetable matter is derived from -and/or spp claim 3 , or an extract thereof.6cannabis.. A plant-based composition of wherein the vegetable matter is derived from7Cannabis sativa, Cannabis ruderalisCannabis indica.. A plant-based composition of wherein the vegetable matter is derived from claim 3 , or8cannabis. A plant-based composition of comprising a extract.9. A plant-based composition of comprising cannabinoids.10. A plant-based composition of comprising Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) claim 3 , cannabigerol ...

Method and device for metering the additive for regenerating a diesel particulate filter

A method for metering an additive for a regeneration process of a particle filter activated in the exhaust gas system of an internal combustion engine, in particular of a diesel engine, the quantity of the additive to be metered in being calculated from the soot production of the internal combustion engine.

Microlens Having a Carrier-Free Optical Interference Filter

An apparatus and a method for producing the apparatus are described, wherein the apparatus includes a substrate with a photodetector and a dielectric arranged on the substrate. Further, the apparatus includes a microlens arranged on a first side of the dielectric. The microlens is configured to steer incident radiation onto the photodetector. Moreover, the apparatus includes a carrier-free optical interference filter. The microlens is arranged between the photodetector and the interference filter, and the interference filter has a plane surface on a side facing away from the photodetector. 1. An apparatus , comprisinga substrate with a photodetector and a dielectric that is arranged on the substrate;a microlens arranged on a first side of the dielectric facing away from the substrate and configured to steer incident radiation onto the photodetector; anda carrier-free optical interference filter,wherein the microlens is arranged between the photodetector and the interference filter,wherein the interference filter has a plane surface on a side facing away from the dielectric.2. The apparatus of claim 1 , wherein at least the plane surface of the interference filter is arranged parallel to the first side of the dielectric.3. The apparatus of claim 1 , wherein the microlens has a plane microlens surface on a side facing away from the photodetector claim 1 , and wherein the interference filter is in direct contact with at least the plane of the microlens surface.4. The apparatus of claim 3 , wherein the microlens is structured into the first side of the dielectric claim 3 , wherein the plane microlens surface is coplanar with the first side of the dielectric claim 3 , and wherein the interference filter is in direct contact with both the plane microlens surface and the first side of the dielectric.5. The apparatus of claim 3 , wherein the plane microlens surface is spaced apart from the first side of the dielectric claim 3 , and wherein at least portions of the ...

METHODS AND APPARATUSES FOR FACILITATING P-CSCF RESTORATION WHEN A P-CSCF FAILURE HAS OCCURRED

A method of facilitating P-CSCF restoration when a P-CSCF failure has occurred is disclosure. The method comprises a Proxy Call Session Control Function, ‘P-CSCF’ receiving a Session Initiation Protocol, ‘SIP’, message when said P-CSCF has been selected as an alternative P-CSCF to a failed P-CSCF and providing, to an associated Policy and Charging Rules Function, ‘PCRF’, a message comprising an indication that P-CSCF restoration is required. 113-. (canceled)14. A method , performed by a user equipment (UE) in a communication system , of facilitating Proxy Call Session Control Function (P-CSCF) restoration when a P-CSCF failure has occurred , the method comprising:releasing, as part of a network node initiated procedure, a current Internet Protocol (IP) Multimedia Subsystem (IMS) connection,wherein the releasing is initiated based on a P-CSCF restoration indication which is sent from a node for controlling policy to the third network node; andsending a Session Initiation Protocol (SIP) message for IMS registration for the UE, to a Serving Call Session Control Function (S-CSCF) after the P-CSCF restoration indication is sent.15. A method of a Serving Call Session Control Function (S-CSCF) for a restoration procedure of a Proxy Call Session Control Function (P-CSCF) , comprising:receiving a terminating Session Initiation Protocol (SIP) message;detecting a P-CSCF failure on a P-CSCF;causing a node for controlling policy to send a P-CSCF restoration indication to a network node; andreceiving another SIP message for Internet Protocol (IP) Multimedia Subsystem (IMS) registration for a User Equipment (UE) from the UE after sending the P-CSCF restoration indication to the network node,wherein release of a current IMS Packet Data Network (PDN) connection in the UE, as part of the network node initiated procedure is initiated based on the P-CSCF restoration indication.16. A method , performed in a communication system including a Proxy Call Session Control Function (P-CSCF) , ...

Dry powder inhaler

A dry powder inhaler (10) having a chamber (26) divided into first and second blister compartments (28, 30) for storing unused and used portions (34, 36) of a blister strip (12) is provided. A moveable dividing wall (32) separates the first and second blister compartments. One or more arcuate supporting surfaces (38, 40, 42) are disposed in either the first and/or the second blister compartments and these surfaces support the used or unused blister strip during successive actuations of the inhaler. Use of the arcuate supporting surfaces facilities compact coils of unused and used portions of blister strip, thereby reducing the size of the chamber required for the inhaler.

Apparatus for managing the energy supplied to a low-voltage system of a motor vehicle that comprises an energy-recovery stage, and corresponding method

An apparatus and a method for managing the energy supplied to a low-voltage system of a vehicle. The low-voltage system includes a battery, which supplies the first voltage on a low-voltage bus. A system for charging the battery includes an alternator for supplying a charging voltage to the battery, and motor-vehicle loads supplied by the battery and/or by the alternator. A high-voltage system operates at a second voltage higher than said first voltage. The high-voltage system includes the vehicle energy-recovery stage. The second voltage is supplied through an intermediate energy-storage system and a DC-DC converter. A control module that carries out energy-management operations at least by the alternator. The second voltage of the DC-DC converter is regulated via a control procedure of a hysteretic type.

Light emitting diode and method of forming a light emitting diode

A method of forming a Light Emitting Diode (LED) precursor comprising: forming a first semiconducting layer comprising a Group III-nitride on a substrate, selectively removing a portion of the first semiconducting layer to form a mesa structure, and forming a monolithic LED structure. According to the method, the first semiconducting layer has a growth surface on an opposite side of the first semiconducting layer to the substrate. According to the method, the first semiconducting layer is selectively removed to form the mesa structure such that the growth surface of the first semiconducting layer comprises a mesa surface and a bulk semiconducting surface. Further, the monolithic LED structure is formed on the growth surface of the first semiconducting layer such that the monolithic LED structure covers the mesa surface and the bulk semiconducting surface, the monolithic LED structure comprising a plurality of layers, each layer comprising a Group III-nitride, including a second semiconducting layer, an active layer provided on the second semiconducting layer, the active layer configured to generate light, and a p-type semiconducting layer provided on the active layer. A potential barrier is provided between a first portion of the p-type semiconducting layer covering the mesa surface and a second portion of the p-type semiconducting layer covering the bulk semiconducting surface. The potential barrier surrounds the first portion of the p-type semiconducting layer covering the mesa surface.

HANDLING TIMER-BASED RESIZING EVENTS BASED ON ACTIVITY DETECTION

Computer-implemented methods, media, and systems implemented to handling timer-based resizing events based on activity detection can trigger a start of a resize timer. The resize timer can periodically provide a notification to check for resize activity in a user interface displayed on a display device. In response to the notification, an absence of the resize activity can be determined after a threshold inactivity time period has expired from the start of the resize timer. In response, a stop of the resize timer can be triggered. After triggering the stop, a first resize activity associated with a first timestamp can be detected in the user interface. A restart of the resize timer from the first timestamp can be triggered to periodically provide the notification to check for resize activity in the user interface. Subsequent continuation or stopping of the resize timer can be based on further presence or absence of resize activity. 1. A method performed by data processing apparatus , the method comprising:triggering a start of a resize timer configured to periodically provide a notification to check for resize activity in a user interface displayed on a display device;in response to the notification, determining an absence of the resize activity in the user interface after a threshold inactivity time period has expired from the start of the resize timer;triggering a stop of the resize timer in response to determining the absence of the resize activity in the user interface after the threshold inactivity time period has expired;detecting a resize activity in the user interface after triggering the stop of the resize timer; andtriggering a restart of the resize timer to periodically provide the notification to check for resize activity in the user interface.2. The method of claim 1 , wherein the detected resize activity is associated with a first timestamp at which the resize activity was detected claim 1 , the method further comprising:in response to the notification ...

Apparatus for moving metal products and corresponding movement method

A movement apparatus for a metal product, which includes a first guide device and a second guide device configured to guide the movement of the metal product in a direction of feed. The apparatus includes at least one electro-magnetic inductor located between said first guide device and said second guide device.

PAIGE CONTROL FOR ENTERPRISE MOBILE APPLICATIONS

The disclosure generally describes computer-implemented methods, software, and systems for generating and using platform-independent code. A computer-implemented method includes: identifying a user interface library that includes abstractions of user interface elements, each abstraction being platform-independent and associated with platform-specific code including user interface code unique to different platforms; receiving application code at design time that includes an abstraction of a user interface element; and storing the application code for use on a client device. At subsequent execution time, the application code is configured to: determine platform-specific information of the client device; execute platform-specific lines of code appropriate for the client device; and present the user interface element in a user interface of the client device in a way that is appropriate for the client device. 1. A computer-implemented method comprising:identifying a user interface library that includes abstractions of user interface elements, each abstraction being platform-independent and associated with platform-specific code including user interface code unique to different platforms;receiving application code at design time that includes an abstraction of a user interface element; and determine platform-specific information of the client device;', 'execute platform-specific lines of code appropriate for the client device; and', 'present the user interface element in a user interface of the client device in a way that is appropriate for the client device., 'storing the application code for use on a client device, wherein, at subsequent execution time, the application code is configured to2. The method of claim 1 , wherein the abstraction is a page control.3. The method of claim 2 , wherein the page control includes at least a header claim 2 , a body claim 2 , and a footer.4. The method of claim 1 , wherein the platform-specific information includes an operating system ...

METHODS AND COMPOSITIONS FOR TREATING PAIN

Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy. 1. An inhalable analgesic composition comprising microparticles of a diketopiperazine and a peptide comprising less than 20 amino acids; wherein said composition is effective at relieving pain.2. The inhalable analgesic composition of claim 1 , wherein the peptide comprises at least three amino acids independently selected from arginine claim 1 , phenylalanine claim 1 , leucine claim 1 , isoleucine claim 1 , norleucine claim 1 , tyrosine claim 1 , serine claim 1 , proline claim 1 , and tryptophan.3. The inhalable analgesic composition of claim 2 , wherein the peptide is an opioid receptor agonist.4. The inhalable analgesic composition of claim 2 , wherein the peptide is an amino acid sequence of from three to eight amino acids in length.5. The inhalable analgesic composition of claim 4 , wherein the peptide is a four amino acid sequence and the composition is for pulmonary administration.6. The inhalable analgesic composition of claim 4 , wherein the peptide comprises: Trp-(D)Pro-Ser-Phe-NH(SEQ ID NO: 3) claim 4 , Trp-(D)Ser-Ser-Phe-NH(SEQ ID NO: 4) claim 4 , Dmt-D-Arg-Phe-Lys-NH(SEQ ID NO: 5) claim 4 , Ac-His-(D)Phe-Arg-(D)Trp-Gly-NH(SEQ ID NO: 6) claim 4 , or Ac-Nle-Gln-His-(D)Phe-Arg-(D)Trp-Gly-NH(SEQ ID NO:7).7. The inhalable analgesic composition of claim 1 , wherein the peptide binds to a μ opioid receptor claim 1 , a δ opioid receptor claim 1 , or a κ opioid receptor claim 1 , or combinations of receptors thereof claim 1 , of cells in the central or ...

Diketopiperazine salts for drug delivery and related methods

Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization. 1. A microparticulate system for drug delivery comprising a composition comprising: microparticles of a pharmaceutically acceptable anion of a diketopiperazine compound comprising a carboxylate group , a divalent cation , and a biologically active agent.2. The microparticulate system of wherein said biologically active agent is a hormone claim 1 , an anticoagulant claim 1 , an immunomodulating agent claim 1 , a cytotoxic agent claim 1 , an antibiotic claim 1 , an antiviral claim 1 , an antisense claim 1 , an antigen claim 1 , an antibody or an active fragment or an analog thereof.3. The microparticulate system of wherein said biologically active agent is insulin claim 1 , a cannabinoid claim 1 , heparin claim 1 , calcitonin claim 1 , felbamate claim 1 , parathyroid hormone or a fragment thereof claim 1 , growth hormone claim 1 , erythropoietin claim 1 , glucagon-like peptide-1 claim 1 , somatotrophin-releasing hormone claim 1 , follicle stimulating hormone claim 1 , cromolyn claim 1 , adiponectin claim 1 , RNAse claim 1 , ghrelin claim 1 , zidovudine claim 1 , didanosine claim 1 , tetrahydrocannabinol claim 1 , atropine claim 1 , granulocyte colony stimulating factor claim 1 , lamotrigine claim 1 , chorionic gonadotropin releasing factor claim 1 , luteinizing releasing hormone claim 1 , β-galactosidase claim 1 , or Argatroban.4. The microparticulate system of wherein said biologically active agent is insulin.5. The microparticulate system of wherein said biologically active agent is ...

METHOD OF ENABLING SLICE SECURITY SEPARATION

A mobile network system comprises a security device and a network device. The security device stores slice security requirements which are different for each slice ID (identification). The slice ID indicates a network slice in a core network. The network device transmits, to the security device, a Slice Security Request including the slice ID. The network device receives, from the security device, a Slice Security Response including the slice security requirements related to the slice ID. The network device selects, based on the slice security requirements, a security algorithm for the network slice. 1. A security device used in a mobile network comprising:a memory to store slice security requirements which are different for each slice ID, the slice ID indicating a network slice in a core network; anda transmitter to transmit the slice security requirements to a network device used in the mobile network in response to a request for selecting a security algorithm for the network slice.2. A network device used in the mobile network comprising:a transmitter to transmit, to a security device used in the mobile network, a Slice Security Request including a slice ID which indicates a network slice in a core network;a receiver to receive, from the security device, a Slice Security Response including slice security requirements related to the slice ID; anda controller to select, based on the slice security requirements, a security algorithm for the network slice.3. The network device according to claim 2 , further comprising: a processor to create an Authentication Vector based on the slice security requirements.4. A mobile network system comprising:a security device; anda network device; whereinthe security device is configured to store slice security requirements which are different for each slice ID, the slice ID indicating a network slice in a core network, andthe network device is configured to transmit, to the security device, a Slice Security Request including the ...

LOAD CONTROL FROM CONTROL PLANE CIoT EPS OPTIMISATION

A core network node supporting Control Plane CIoT (Celluar Internet of Things) EPS (Evolved Packet System) Optimization includes a transmitter configured to transmit to a radio access network node an information indicating overload from data transfer via the Control Plane CIoT EPS Optimization. A radio access network node includes a receiver configured to receive, from a core network node, an information indicating overload from data transfer via Control Plane CIoT (Celluar Internet of Things) EPS (Evolved Packet System) Optimization. 1. A core network node supporting Control Plane CIoT (Celluar Internet of Things) EPS (Evolved Packet System) Optimization , comprising:a transmitter configured to transmit to a radio access network node an information indicating overload from data transfer via a Control Plane.2. The core network node according to claim 1 , whereinthe transmitter is further configured to transmit an Overload Start Message with the information indicating the overload from the data transfer via the Control Plane.3. The core network node according to claim 2 , further comprising:a memory storing a instructions; and 'request the radio access network node to not accept a RRC (Radio Resource Control) connection request for the data transfer via the Control Plane to the core network node.', 'at least one processor configured to process the instructions to4. The core network node according to claim 3 , whereinthe at least one processor is further configured to process the instructions to request the radio access network node to reject the RRC connection request for the data transfer via the Control Plane.5. The core network node according to claim 3 , whereinthe at least one processor is further configured to process the instructions to request the radio access network node to reroute the RRC connection request for the data transfer via the Control Plane to another core network node.6. A radio access network node claim 3 , comprising:a receiver configured to ...

HEAT-STABLE DRY POWDER PHARMACEUTICAL COMPOSITIONS AND METHODS

Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution. 1. A dry powder pharmaceutical formulation comprising a peptide , a protein , or a derivative or analog of said peptide or protein; a citrate or tartrate , a cationic salt , an amino acid , and/or a pharmaceutically acceptable carrier or excipient.2. The dry powder pharmaceutical formulation of claim 1 , wherein the peptide claim 1 , protein claim 1 , derivative claim 1 , or analog thereof is oxytocin claim 1 , an oxytocin derivative or an oxytocin analog.3. The dry powder pharmaceutical formulation of claim 1 , wherein the citrate is sodium citrate claim 1 , or zinc citrate.4. The dry powder pharmaceutical formulation of claim 1 , wherein the cationic salt is a divalent cation salt which is zinc chloride claim 1 , zinc citrate claim 1 , zinc acetate claim 1 , magnesium chloride or calcium chloride.5. The dry powder pharmaceutical formulation of claim 1 , wherein the pharmaceutically acceptable carrier or excipient is a sugar selected from mannose claim 1 , mannitol claim 1 , trehalose claim 1 , or sorbitol.6. The dry powder pharmaceutical formulation of claim 1 , wherein the pharmaceutically acceptable carrier or excipient is polyvinylpyrrolidone claim 1 , polyethylene glycol claim 1 , or a diketopiperazine.7. The dry powder pharmaceutical formulation of claim 6 , wherein the diketopiperazine is fumaryl diketopiperazine or succinyl diketopiperazine.8. The dry powder pharmaceutical formulation of claim 1 , wherein the citrate salt is in an amount ranging from 100 to 20 equivalents per mole of the oxytocin claim 1 , ...

Reagent for mass spectrometry

The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

DETERMINING A TIME TO PERFORM AN UPDATE

Apparatuses, methods, and systems are disclosed for determining a time to perform an update. One method () includes transmitting () first information indicating an initial value. The method () includes transmitting () second information indicating an update interval corresponding to the initial value. The method () includes updating () an identifier at a time determined based on the initial value and the update interval. 1. A method comprising:transmitting first information indicating an initial value;transmitting second information indicating an update interval corresponding to the initial value; andupdating an identifier at a time determined based on the initial value and the update interval.2. The method of claim 1 , wherein the identifier is updated using a function determined based on the initial value and the update value.3. The method of claim 1 , wherein the initial value comprises an initial counter value claim 1 , an initial time value claim 1 , or a random value.4. The method of claim 1 , wherein the update interval comprises a pattern for altering the initial value to determine an updated value.5. The method of claim 1 , wherein the update interval comprises an update time period claim 1 , and the identifier is updated each time the update time period elapses.6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. A method comprising:receiving first information indicating an initial value;receiving second information indicating an update interval corresponding to the initial value; andupdating an identifier at a time determined based on the initial value and the update interval.12. The method of claim 11 , wherein the identifier is updated using a function determined based on the initial value and the update value.13. The method of claim 11 , wherein the initial value comprises an initial counter value claim 11 , an initial time value claim 11 , or a random value.14. The method of claim 11 , wherein the update interval comprises a pattern ...

METHOD AND SYSTEM FOR SUPPORTING TRANSPORT OF DATA PACKETS IN A NETWORK

A method for supporting transport of data packets in a network, wherein the data packets are transmitted from a source node to a destination node by employing a tunnel from a first tunnel endpoint to a second tunnel endpoint, wherein a tunnel header is added to the data packets at the first tunnel endpoint, wherein the data packets are transmitted between the tunnel endpoints via a network domain that includes one or more intermediate nodes functioning as transport network, and wherein the intermediate nodes forward the data packets, is characterized in that the tunnel is provided in the form of a virtual tunnel by removing the tunnel header from the data packets where the data packets enter the network domain and adding back the tunnel header to the data packets where the data packets exit the network domain. A corresponding system for supporting transport of data packets is disclosed. 1. Method for supporting transport of data packets in a network , in particular service and/or user aware transport of data packets ,wherein said data packets are transmitted from a source node to a destination node by employing a tunnel from a first tunnel endpoint (A) to a second tunnel endpoint (B),wherein a tunnel header is added to said data packets at said first tunnel endpoint (A),wherein said data packets are transmitted between said tunnel endpoints via a network domain that includes one or more intermediate nodes functioning as transport network, andwherein said intermediate nodes forward said data packets, charactarized in that said tunnel is provided in the form of a virtual tunnel byremoving said tunnel header from said data packets where said data packets enter said network domain andadding back said tunnel header to said data packets where said data packets exit said network domain.2. Method according to claim 1 , wherein said tunnel endpoints include an access node claim 1 , an eNodeB claim 1 , a Serving GW claim 1 , a PDN GW claim 1 , a SGSN claim 1 , a GGSN and/or a ...

ESTABLISHING A CONNECTION WITH A DUAL REGISTERED DEVICE

Apparatuses, methods, and systems are disclosed for establishing a connection with a dual registered device. One method includes receiving a first request to establish an internet protocol multimedia subsystem session with a first device, wherein the first device is dual registered to: a first network access supporting 5G core network connectivity; and a second network access supporting evolved packet core network connectivity and circuit switched network connectivity, wherein the first device has connectivity to an internet protocol multimedia subsystem via either the first network access or the second network access. The method includes determining first information corresponding to a network access connectivity selected from the first network access and the second network access through which the first device has internet protocol connectivity with the internet protocol multimedia subsystem. The method includes transmitting a second request to a first network function to retrieve second information. 1. A method comprising: a first network access supporting 5G core network connectivity; and', 'a second network access supporting evolved packet core network connectivity and circuit switched network connectivity, wherein the first device has connectivity to an internet protocol multimedia subsystem via either the first network access or the second network access;, 'receiving a first request to establish an internet protocol multimedia subsystem session with a first device, wherein the first device is dual registered todetermining first information corresponding to a network access connectivity selected from the first network access and the second network access through which the first device has internet protocol connectivity with the internet protocol multimedia subsystem; andtransmitting a second request to a first network function to retrieve second information corresponding to voice support over packet switched connectivity over the internet protocol multimedia ...

DETERMINING A NETWORK SYSTEM ISSUE

Apparatuses, methods, and systems are disclosed for determining a network system issue. One method () includes a first network device determining () a system issue corresponding to at least one second network device. The first network device is an analytics entity in a cellular network and the at least one second network device is a managed entity in the cellular network, and the system issue comprises a software issue, a hardware issue, a compatibility issue, an issue with an interaction between a plurality of second network devices comprising the at least one second network device, an issue with an interaction between the at least one second network device and another device, or some combination thereof. The analytics entity comprises an entity that analyzes one or more devices to determine descriptive analytics, predictive analytics, and/or prescriptive analytics. The method () includes providing () a notification indicating the system issue. 1. A method comprising:determining, at a first network device, a system issue corresponding to at least one second network device, wherein the first network device is an analytics entity in a cellular network and the at least one second network device is a managed entity in the cellular network, and the system issue comprises a software issue, a hardware issue, a compatibility issue, an issue with an interaction between a plurality of second network devices comprising the at least one second network device, an issue with an interaction between the at least one second network device and another device, or some combination thereof, and wherein the analytics entity comprises an entity that analyzes one or more devices to determine descriptive analytics, predictive analytics, prescriptive analytics, or some combination thereof; andproviding a notification indicating the system issue.2. The method of claim 1 , wherein determining the system issue comprises determining the system issue based on performance of the at least one ...

METHOD FOR USER PLANE CONNECTION ACTIVATION OR DEACTIVATION PER SESSION

This disclosure provides a User Equipment (UE), including: a transmitter configured to transmit at least one Protocol Data Unit (PDU) session identifier (ID), each of which indicates a PDU session that the UE needs to use in a Non Access Stratum (NAS) Service Request message to a Mobility Management Function (MMF) via an access network (AN) node when the UE has user data to send. 111-. (canceled)12. A controlling method in User Equipment (UE) , comprising:transmitting, in a Non Access Stratum (NAS) Service Request message, information indicating at least one Protocol Data Unit (PDU) session identifier (ID), each PDU session ID indicating one of multiple PDU sessions that the UE uses, to a network node for mobility management via an Access Network (AN) node when the UE has user data to send,wherein the information indicating the at least one PDU session ID indicates at least one session to be activated.13. The controlling method according to claim 12 , further comprising:receiving a message for Radio Resource Control (RRC) connection reconfiguration for one of the multiple PDU sessions from the AN node, after the UE transmits the information indicating the at least one PDU session ID.14. The controlling method according to claim 13 , further comprising:releasing a resouce for at least one PDU session among established multiple PDU sessions based on the message.15. A controlling method in a Session Management Function (SMF) node claim 13 , comprising:transmitting an inactivity timer value for specifying a period to a User Plane Function (UPF) node; anddetermining that a Protocol Data Unit (PDU) session among multiple PDU sessions established in User Equipment (UE) is deactivated in a case where the UPF node determines that the PDU session has no data transfer based on the inactivity timer value.16. The controlling method according to claim 15 , further comprising:transmitting a request for release of a resource related to the determined PDU session, to a network node ...

Delivery of Active Agents

A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site. 1. A method of administering a labile active agent to a patient comprising:administering to said patient in need thereof an effective amount of a pharmaceutical composition comprising a diketopiperazine and one or more active agents by pulmonary inhalation;wherein the one or more active agents is sensitive to enzymatic deactivation or degradation when in contact with local peripheral and vascular tissue, and said pharmaceutical composition provides avoidance of enzymatic deactivation or degradation of the one or more active agents.2. The method of claim 1 , wherein said diketopiperazine is 2 claim 1 ,5-diketo-3 claim 1 ,6-di(4-X-aminobutyl)piperazine; wherein X is selected from the group consisting of succinyl claim 1 , glutaryl claim 1 , maleyl claim 1 , and fumaryl; or a pharmaceutically acceptable salt thereof.3. The method of claim 1 , wherein the pharmaceutical composition is a dry powder formulation.4. The method of claim 3 , wherein said dry powder formulation further comprises a pharmaceutically acceptable carrier or excipient.5. The method of claim 3 , wherein the dry powder formulation is administered using a dry powder inhalation system.6. The method of claim 1 , wherein the at least one of the one or more active agents is a vasoactive agent.7. The method of claim 6 , wherein the vasoactive agent is a prostaglandin.8. The method of claim 7 , ...

ACCESSING A DENIED NETWORK RESOURCE

Apparatuses, methods, and systems are disclosed for accessing a denied network resource. One apparatus includes a processor and a transceiver that receives a first message indicating that access to a network resource in a mobile communication network is denied due to authorization specific for the network resource. Here, the network resource is identified by at least one of: a network slice identifier and a data network name (“DNN”). The processor monitors for a condition to be met prior to initiating a new request for establishing an access to the denied network resource and initiates signaling towards the network to establish an access to the denied network resource in response to the condition being met. 1. A method comprising:receiving at a UE a first message indicating that access to a network resource in a mobile communication network is denied due to authorization specific for the network resource, wherein the network resource is identified by at least one of: a network slice identifier and a data network name (“DNN”);monitoring for a condition to be met prior to initiating a new request for establishing an access to the denied network resource; andinitiating signaling towards the network to establish an access to the denied network resource in response to the condition being met.2. The method of claim 1 , wherein the first message includes a cause value indicating a reason for the denial of access to the network resource claim 1 , wherein the cause value indicates that access to a network resource in a mobile communication network is denied due to one of: failed authentication of the UE claim 1 , revoked authorization claim 1 , and incomplete authentication.3. The method of claim 1 , wherein the first message further indicates the condition to be met before initiating signaling to establish access to the network resource for which access is denied.4. The method of claim 1 , wherein the first message further includes an empty list of allowed network resources ...

Bi-Specific Therapeutic Proteins for Tissue Repair

Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue.

DIKETOPIPERAZINE SALTS FOR DRUG DELIVERY AND RELATED METHODS

Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization. 2. The dry powder of claim 1 , wherein said PDE5 inhibitor is selected from the group consisting of sildenafil citrate claim 1 , vardenafil hydrochloride and tadalafil.3. The dry powder of claim 1 , wherein said PDE5 inhibitor is tadalafil.4. The dry powder of claim 1 , wherein the heterocyclic compound comprises a diketopiperazine.5. The dry powder of claim 1 , wherein said cation is selected from the group consisting of sodium claim 1 , potassium claim 1 , calcium claim 1 , lithium claim 1 , triethylamine claim 1 , butylamine claim 1 , diethanolamine and triethanolamine.6. The dry powder of claim 1 , wherein said cation is sodium.7. The dry powder of claim 1 , wherein the dry powder is formed by the removal of a solvent from a solution containing the PDE5 inhibitor claim 1 , the pharmaceutically acceptable salt of the heterocyclic compound claim 1 , and the cation.8. The dry powder of claim 7 , wherein the removal of the solvent is achieved by spray drying.9. The dry powder of claim 7 , wherein the removal of the solvent is achieved by evaporation.10. The dry powder of claim 7 , wherein the removal of the solvent is achieved by lyophilization.11. The dry powder of claim 1 , wherein the dry powder is prepared by a method that includes micronizing a solid to form particles of the dry powder.12. The dry powder of claim 11 , wherein the particles of the dry powder are suitable for pulmonary delivery.13. The dry powder of claim 11 , wherein the particles of the dry powder have a rugosity ...

KEY REFRESH FOR SMALL-DATA TRAFFIC

Apparatuses, methods, and systems are disclosed for key refresh triggering. One apparatus includes a transceiver and a processor that starts a counter corresponding to a UE having a small-data traffic pattern. In response to the transceiver receiving small-data traffic associated with the UE, the processor determines if a security key is valid based on a value of the counter. If the value of the counter indicates the security key is invalid, then the processor triggers a key refresh procedure. The processor relays the small-data traffic in response to the UE having a valid security key. 1starting a counter corresponding to a remote unit having a small-data traffic pattern;receiving small-data traffic associated with the remote unit;determining if a security key is valid based on a value of the counter;triggering a key refresh procedure if the value of the counter indicates the security key is invalid; andrelaying the small-data traffic in response to the remote unit having a valid security key.. A method of a network function comprising: This application is a continuation of patent application Ser. No. 16/746,471 entitled “KEY REFRESH FOR SMALL-DATA TRAFFIC” filed on Jan. 17, 2020 which claims priority to U.S. Provisional Patent Application No. 62/794,476 entitled “Key Refresh Triggering for IoT Devices” and filed on Jan. 18, 2019 for Andreas Kunz, Genadi Velev, Joachim Loehr, Prateek Basu Mallick, Ravi Kuchibhotla, and Alexander Golitschek Edler von Elbwart, which application is incorporated herein by reference.The subject matter disclosed herein relates generally to wireless communications and more particularly relates to security key refresh triggering for small-data traffic (e.g., among IoT devices).The following abbreviations are herewith defined, at least some of which are referred to within the following description: Third Generation Partnership Project (“3GPP”), Fifth Generation Core Network (“5CG”), Fifth Generation System (“5GS”), Absolute Radio Frequency ...

COMMUNICATION TERMINAL, NETWORK DEVICE, COMMUNICATION METHOD, AND NON-TRANSITORY COMPUTER READABLE MEDIUM

A communication terminal () according to the present disclosure includes: a control unit () configured to, in a case of a movement from a communication area formed by the 5GS to a communication area formed by the EPS or a movement from a communication area formed by the EPS to a communication area formed by the 5GS, determine whether or not a communication system forming a communication area at a movement destination can satisfy requirements of services; and a communication unit () configured to, when it is determined that the communication system forming the communication area at the movement destination can satisfy the requirements of the services, send a connection request message to the communication system forming the communication area at the movement destination. 1. A communication terminal comprising:at least one processor comprising hardware; andat least one memory operatively coupled with the at least one processor, whereinthe at least one processor is configured to:obtain a security context of the communication terminal, andderive, using information included in the security context of the communication terminal, at least one security key to be used in a second communication network having a second network device operating as a mobility management entity (MME) during a handover procedure to handover the communication terminal from a first communication network having a first network device operating as an access and mobility management function (AMF) to the second communication network,wherein the security context is obtained after the first network device checks access rights and security capabilities of the communication terminal during the handover procedure, andwherein the first communication network comprises a 5th generation system (5GS) network and the second communication network comprises an evolved packet system (EPS) network.2. The communication terminal according to claim 1 , wherein the at least one security key is a Non-Access Stratum (NAS) ...

REPORTING MONITORED PARAMETER INFORMATION

Apparatuses, methods, and systems are disclosed for reporting monitored parameter information. One method includes receiving an indication to monitor parameters in an idle mode. The method includes monitoring the parameters in the idle mode. The method includes transmitting a request to a first base station. The method includes, in response to not receiving a correct response from the first base station: performing a cell reselection resulting in selection of a second base station; and transmitting a failure report to the second base station. The failure report includes information corresponding to the parameters monitored in the idle mode. 1receiving an indication to monitor parameters in an idle mode;monitoring the parameters in the idle mode;transmitting a request to a first base station; and performing a cell reselection resulting in selection of a second base station; and', 'transmitting a failure report to the second base station, wherein the failure report comprises information corresponding to the parameters monitored in the idle mode., 'in response to not receiving a correct response from the first base station. A method comprising: This application is a continuation of patent application Ser. No. 16/010,912 entitled “REPORTING MONITORED PARAMETER INFORMATION” filed on Jun. 18, 2018, which claims priority to U.S. patent application Ser. No. 62/521,266 entitled “REPORTING OF ROGUE BASE STATION DETECTION” and filed on Jun. 16, 2017 for Andreas Kunz which is incorporated herein by reference in its entirety.The subject matter disclosed herein relates generally to wireless communications and more particularly relates to reporting monitored parameter information.The following abbreviations are herewith defined, at least some of which are referred to within the following description: Third Generation Partnership Project (“3GPP”), Fifth Generation (“5G”), Authentication Authorization and Accounting (“AAA”), Positive-Acknowledgment (“ACK”), Acknowledged Mode (“AM”), ...

METHOD FOR USER PLANE CONNECTION ACTIVATION OR DEACTIVATION PER SESSION

This disclosure provides a User Equipment (UE), including: a transmitter configured to transmit at least one Protocol Data Unit (PDU) session identifier (ID), each of which indicates a PDU session that the UE needs to use in a Non Access Stratum (NAS) Service Request message to a Mobility Management Function (MMF) via an access network (AN) node when the UE has user data to send. 1. A controlling method in User Equipment (UE) , comprising:transmitting, in a Non Access Stratum (NAS) Service Request message, information indicating at least one Protocol Data Unit (PDU) session identifier (ID), each of the at least one PDU session ID indicating a PDU session by which pending uplink user data is to be sent to a network node for mobility management via an Access Network (AN) node,wherein the information indicating the at least one PDU session ID indicates at least one PDU session to be activated, the at least one PDU session being identified by the at least one PDU session ID.2. The controlling method according to claim 1 , further comprising:receiving a message for Radio Resource Control (RRC) connection reconfiguration for a PDU session indicated by one of the at least one PDU session ID from the AN node, after the UE transmits the information indicating the at least one PDU session ID.3. The controlling method according to claim 2 , further comprising:releasing a resource for the at least one PDU session based on the received message.4. A controlling method in a Session Management Function (SMF) node in a core network claim 2 , comprising:transmitting an inactivity timer value for specifying a period to a User Plane Function (UPF) node in the core network; anddetermining that a Protocol Data Unit (PDU) session established in User Equipment (UE) is deactivated based on a determination by the UPF node that the PDU session has no data transfer based on the inactivity timer value.5. The controlling method according to claim 4 , further comprising:transmitting a request for ...

METHOD AND APPARATUS FOR SHORT CODE DIALING FOR RESTRICTED SERVICES FOR UNAUTHENTICATED USER EQUIPMENT

A method and apparatus provide for attachment for restricted local operator services for an apparatus, such as a user equipment. An attach procedure for the restricted local operator services for the apparatus can be performed. A proxy call session control function address for the restricted local operator services can be received during the attach procedure. A session initiation protocol register request message can be generated. The session initiation protocol register request message can include an indication for the restricted local operator services and can include an internet protocol multimedia public user identification based on an identification of the apparatus. The session initiation protocol register request message to the proxy call session control function address can be sent, the session initiation protocol register request message can include the indication for the restricted local operator services. 1performing an attach procedure for restricted local operator services for an apparatus;receiving during the attach procedure a proxy call session control function address for the restricted local operator services;generating session initiation protocol register request message, the session initiation protocol register request message including an indication for the restricted local operator services and including an internet protocol multimedia public user identification based on an identification of the apparatus;sending the session initiation protocol register request message to the proxy call session control function address; andreceiving a response message indicating the apparatus is registered with the restricted local operator services of an internet protocol multimedia core network subsystem.. A method, comprising: The present disclosure is directed to a method and apparatus for signaling on a wireless network. More particularly, the present disclosure is directed to a method and apparatus for short code dialing for restricted services for ...

Locationing device for a machining point on a workpiece

A device for determining a location on an elongated workpiece, characterized in that the device comprises:a frame movable in a first direction, preferably in a longitudinal direction of the workpiece, positioning means to position the frame in relation to the sides of the workpiece, movable means movable in a second direction, preferably in a transverse direction with respect to the frame, a measuring point, the movement in first direction and second direction used to move measuring point in said directions, measuring equipment for determining the location of the measuring point in transverse and longitudinal respect to the workpiece.

COMMUNICATION SYSTEM

A communication entity includes a Proxy Call Session Control Function (P-CSCF). The P-CSCF includes a transceiver and a controller. The transceiver is operable to receive a register request from a user equipment (UE) in a visited public land mobile network (VPLMN). The controller is operable to: retrieve a network identifier (PLMN ID) for the VPLMN by requesting the PLMN ID where the UE is currently located from a Policy Control Rule Function (PCRF); access a database to obtain a list of local emergency numbers for the VPLMN; and include the retrieved PLMN ID in the register request before forwarding the register request to a Call Session Control Function (CSCF). 1: A communication entity , comprising: a transceiver operable to receive a register request from a user equipment (UE) in a visited public land mobile network (VPLMN); and', retrieve a network identifier (PLMN ID) for the VPLMN by requesting the PLMN ID where the UE is currently located from a Policy Control Rule Function (PCRF);', 'access a database to obtain a list of local emergency numbers for the VPLMN; and', 'include the retrieved PLMN ID in the register request before forwarding the register request to a Call Session Control Function., 'a controller operable to], 'a Proxy Call Session Control Function, (P-CSCF), the P-CSCF comprising2: The communication entity according to claim 1 , wherein the transceiver is further operable to receive an invite for establishing a non-UE detectable emergency call from the UE claim 1 , in the VPLMN claim 1 , and wherein the controller is further operable to use the obtained local emergency numbers for detection that a call is the non-UE detectable emergency call.3. (canceled)4: The communication entity according to claim 1 , wherein the controller is further operable to store the PLMN ID.5: The communication entity according to claim 1 , wherein the controller is further operable to include the PLMN ID in a further register request message and to control the ...

GAS DENSIMETER

A gas densimeter for monitoring a pressure or density of a gas in a gas chamber with a housing having a first housing chamber and a measuring chamber, a first coupling, via which the measuring chamber can be connected to the gas chamber, at least one reference bellows, which is connected directly or indirectly in particular to a transmission element, and at least one transmitting and/or monitoring unit, which is or can be operatively connected directly or indirectly to the transmission element. In this regard, the measuring chamber has a gas-permeable connection to the gas chamber via the first coupling and the reference bellows forms a reference chamber filled with a constant amount of a reference gas. A surface section covering the reference chamber is provided or reachable at least partially within the first housing chamber or measuring chamber as a measuring surface for the gas from the gas chamber. 1. A gas densimeter for monitoring a pressure or density of a gas in a gas chamber , the gas densimeter comprising:a housing having a first housing chamber and a measuring chamber;a first coupling, via which the measuring chamber is connectable to the gas chamber, the measuring chamber having a gas-permeable connection to the gas chamber via the first coupling;at least one reference bellows that is connected directly or indirectly to a transmission element, the reference bellows forming a reference chamber filled with a constant amount of a reference gas;at least one transmitting and/or monitoring unit that is operatively connected directly or indirectly to the transmission element; anda surface section covering the reference chamber or reachable at least partially within the first housing chamber or measuring chamber as a measuring surface for the gas from the gas chamber.2. The gas densimeter according to claim 1 , wherein the surface section covering the reference bellows has an effective measuring surface which is smaller by 2% to 80% claim 1 , by 5% to 50% claim ...

METHODS AND COMPOSITIONS FOR TREATING PAIN

Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy. 128.-. (canceled)29. A method of reducing side effects in an opioid-dependent patient comprising reducing the opioid dosage amount while administering to the patient a composition comprising an inhalable , analgesic composition comprising:microparticles of a diketopiperazine; anda peptide comprising less than 20 amino acids;wherein said composition is effective at relieving pain, and wherein the peptide is an opioid receptor agonist30. The method of claim 29 , wherein the peptide comprises at least three amino acids independently selected from arginine claim 29 , phenylalanine claim 29 , leucine claim 29 , isoleucine claim 29 , norleucine claim 29 , tyrosine claim 29 , serine claim 29 , proline claim 29 , and tryptophan.31. The method of claim 30 , wherein the peptide is an amino acid sequence of from three to eight amino acids in length.32. The method of claim 31 , wherein the peptide is a four amino acid sequence and the composition is for pulmonary administration33. The method of claim 31 , wherein the peptide comprises: (D)Phe-(D)Phe-(D)Ile-(D)Arg-NH(SEQ ID NO: 1) claim 31 , (D)Phe-(D)Phe-(D)Nle-(D)Arg-NH(SEQ ID NO: 2) claim 31 , Trp-(D)Pro-Ser-Phe-NH(SEQ ID NO: 3) claim 31 , Trp-(D)Ser-Ser-Phe-NH(SEQ ID NO: 4); Dmt-D-Arg-Phe-Lys-NH(SEQ ID NO: 5) claim 31 , Ac-His-(D)Phe-Arg-(D)Trp-Gly-NH(SEQ ID NO: 6) claim 31 , and Ac-Nle-Gln-His-(D)Phe-Arg-(D)Trp-Gly-NH(SEQ ID NO:7)34. The method of claim 29 , wherein the composition comprises a dry powder claim 29 , ...

FAST-ACTING PLANT-BASED MEDICINAL COMPOUNDS AND NUTRITIONAL SUPPLEMENTS

Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits. 1. A fast-acting plant-based composition formulated for oral delivery comprising (i) THC and/or CBD and (ii) N-[8-(2-hydroxybenzoyl) amino] caprylate.2. A fast-acting plant-based composition formulated for oral delivery comprising (i) vegetable matter with an aqueous solubility of less than 0.1 mg/ml and (ii) N-[8-(2-hydroxybenzoyl) amino]caprylate.3. A plant-based composition comprising vegetable matter and an N-acylated fatty amino acid or a salt thereof.4. A plant-based composition comprising a botanical product and an N-acylated fatty amino acid or a salt thereof.5Calophyllum brasiliense, Calophyllum caledonicurn, Calophyllum inophyllum, Calophyllum soulattri, Uncaria tomentosa, Thymus vulgaris, Matricaria recutita, Salix alba, Calendula officinalis, Usnea barbata, Ligusticum porteriiosha, Gaultheria procumbens, Camellia sinensis, Vaccinium myrtillus, Melissa officinalis, Allium sativum, Camellia sinensis, Krameria triandra, Punica granatum, Viburnum plicatum, Nicotiana tabacum, Duboisia hopwoodii, Asclepias syriaca, Curcuma longa, Cannabis sativa, Cannabis indica, Cannabis ruderalisAcer. A plant-based composition of wherein the vegetable matter is derived from -and/or spp claim 3 , or an extract thereof.6Cannabis.. A plant-based composition of wherein the vegetable matter is derived from7Cannabis sativa, Cannabis ruderalisCannabis indica.. A plant-based composition of wherein the vegetable matter is derived from claim 3 , or8Cannabis. A plant-based composition of comprising a extract.9. A plant-based composition of comprising cannabinoids.10. A plant-based composition of comprising Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) claim 3 , cannabigerol ...

METHODS AND COMPOSITIONS FOR TREATING PAIN

Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy. 1. An inhalable , analgesic composition comprising microparticles of a diketopiperazine and a peptide comprising less than 20 amino acids; wherein said composition is effective at relieving pain.2. The inhalable analgesic composition of claim 1 , wherein the peptide comprises at least three amino acids independently selected from arginine claim 1 , phenylalanine claim 1 , leucine claim 1 , isoleucine claim 1 , norleucine claim 1 , tyrosine claim 1 , serine claim 1 , proline claim 1 , and tryptophan.3. The inhalable analgesic composition of claim 2 , wherein the peptide is an opioid receptor agonist.4. The inhalable analgesic composition of claim 2 , wherein the peptide is an amino acid sequence of from three to eight amino acids in length.5. The inhalable analgesic composition of claim 4 , wherein the peptide is a four amino acid sequence and the composition is for pulmonary administration.6. The inhalable analgesic composition of claim 4 , wherein the peptide comprises: (D)Phe-(D)Phe-(D)Ile-(D)Arg-NH(SEQ ID NO: 1) claim 4 , (D)Phe-(D)Phe-(D)Nle-(D)Arg-NH(SEQ ID NO: 2) claim 4 , Trp-(D)Pro-Ser-Phe-NH(SEQ ID NO: 3) claim 4 , Trp-(D)Ser-Ser-Phe-NH(SEQ ID NO: 4) claim 4 , Dmt-D-Arg-Phe-Lys-NH(SEQ ID NO: 5) claim 4 , Ac-His-(D)Phe-Arg-(D)Trp-Gly-NH(SEQ ID NO: 6) claim 4 , or Ac-Nle-Gln-His-(D)Phe-Arg-(D)Trp-Gly-NH(SEQ ID NO:7).7. The inhalable analgesic composition of claim 1 , wherein the peptide binds to a μ opioid receptor claim 1 , a δ opioid receptor claim ...

HEAT-STABLE DRY POWDER PHARMACEUTICAL COMPOSITIONS AND METHODS

Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution. 1. A dry powder pharmaceutical formulation comprising a peptide , a protein , or a derivative or analog of said peptide or protein; a citrate or tartrate , a cationic salt , an amino acid , and/or a pharmaceutically acceptable carrier or excipient.2. The dry powder pharmaceutical formulation of claim 1 , wherein the peptide claim 1 , protein claim 1 , derivative claim 1 , or analog thereof is oxytocin claim 1 , an oxytocin derivative or an oxytocin analog.3. The dry powder pharmaceutical formulation of claim 1 , wherein the citrate is sodium citrate claim 1 , or zinc citrate.4. The dry powder pharmaceutical formulation of claim 1 , wherein the cationic salt is a divalent cation salt which is zinc chloride claim 1 , zinc citrate claim 1 , zinc acetate claim 1 , magnesium chloride or calcium chloride.5. The dry powder pharmaceutical formulation of claim 1 , wherein the pharmaceutically acceptable carrier or excipient is a sugar selected from mannose claim 1 , mannitol claim 1 , trehalose claim 1 , or sorbitol.6. The dry powder pharmaceutical formulation of claim 1 , wherein the pharmaceutically acceptable carrier or excipient is polyvinylpyrrolidone claim 1 , polyethylene glycol claim 1 , or a diketopiperazine.7. The dry powder pharmaceutical formulation of claim 6 , wherein the diketopiperazine is fumaryl diketopiperazine or succinyl diketopiperazine.8. The dry powder pharmaceutical formulation of claim 1 , wherein the citrate salt is in an amount ranging from 100 to 20 equivalents per mole of the oxytocin claim 1 , ...

HEAT-STABLE DRY POWDER PHARMACEUTICAL COMPOSITIONS AND METHODS

Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution. 1. A dry powder pharmaceutical formulation comprising a peptide , a protein , or a derivative or analog of said peptide or protein; a citrate or tartrate , a cationic salt , an amino acid , and/or a pharmaceutically acceptable carrier or excipient.2. The dry powder pharmaceutical formulation of claim 1 , wherein the peptide claim 1 , protein claim 1 , derivative claim 1 , or analog thereof is oxytocin claim 1 , an oxytocin derivative or an oxytocin analog.3. The dry powder pharmaceutical formulation of claim 1 , wherein the citrate is sodium citrate claim 1 , or zinc citrate.4. The dry powder pharmaceutical formulation of claim 1 , wherein the cationic salt is a divalent cation salt which is zinc chloride claim 1 , zinc citrate claim 1 , zinc acetate claim 1 , magnesium chloride or calcium chloride.5. The dry powder pharmaceutical formulation of claim 1 , wherein the pharmaceutically acceptable carrier or excipient is a sugar selected from mannose claim 1 , mannitol claim 1 , trehalose claim 1 , or sorbitol.6. The dry powder pharmaceutical formulation of claim 1 , wherein the pharmaceutically acceptable carrier or excipient is polyvinylpyrrolidone claim 1 , polyethylene glycol claim 1 , or a diketopiperazine.7. The dry powder pharmaceutical formulation of claim 6 , wherein the diketopiperazine is fumaryl diketopiperazine or succinyl diketopiperazine.8. The dry powder pharmaceutical formulation of claim 1 , wherein the citrate salt is in an amount ranging from 100 to 20 equivalents per mole of the oxytocin claim 1 , ...

METHOD AND COMPOSITION FOR TREATING MIGRAINES

A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner. 1. A method of treating symptoms associated with migraine comprising:administering to a subject in need of treatment for migraine symptoms a dry powder pharmaceutical composition comprising an effective amount of a serotonin receptor agonist and a diketopiperazine or a salt thereof.2. The method of claim 1 , wherein the dry powder pharmaceutical composition is administered by inhalation.3. The method of claim 1 , wherein said diketopiperazine is 2 claim 1 ,5-diketo-3 claim 1 ,6-di(4-X-aminobutyl)piperazine; wherein X is selected from the group consisting of succinyl claim 1 , glutaryl claim 1 , maleyl claim 1 , and fumaryl; or a pharmaceutically acceptable salt thereof.4. The method of claim 1 , wherein the dry powder pharmaceutical composition is manufactured as a unit dose for oral inhalation.5. The method of claim 4 , wherein said inhalable dry powder pharmaceutical composition further comprises a pharmaceutically acceptable carrier or excipient.6. The method of claim 4 , wherein the dry powder formulation is administered to said subject by pulmonary inhalation using a breath powered claim 4 , dry powder inhalation system.7. The method of claim 1 , wherein the serotonin receptor agonist is for treating moderate to severe head pain associated with the migraine.8. The method of claim 1 , wherein the serotonin receptor agonist is a triptan.9. The method of claim 8 , wherein the triptan is selected from the group consisting of sumatriptan claim 8 , almotriptan claim 8 , eletriptan claim 8 , frovatriptan claim 8 , naratriptan claim 8 , rizatriptan claim 8 , ...

METHOD AND COMPOSITION FOR TREATING MIGRAINES

A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner. 1. A dry powder pharmaceutical composition comprising an effective amount of a prostaglandin or an analog thereof , and a diketopiperazine or a salt thereof.2. The dry powder pharmaceutical composition of claim 1 , wherein the dry powder pharmaceutical composition is administered by inhalation.3. The dry powder pharmaceutical composition of claim 1 , wherein said diketopiperazine comprises 3 claim 1 ,6-di(4-X-aminobutyl)-2 claim 1 ,5-diketopiperazine; wherein X is at least one of succinyl claim 1 , glutaryl claim 1 , maleyl claim 1 , or fumaryl; or a pharmaceutically acceptable salt thereof.4. The dry powder pharmaceutical composition of claim 1 , wherein the dry powder pharmaceutical composition is manufactured as an inhalable unit dose.5. The dry powder pharmaceutical composition of claim 4 , wherein said inhalable unit dose further comprises a pharmaceutically acceptable carrier or excipient.6. The dry powder pharmaceutical composition of claim 5 , wherein said inhalable unit dose is administered to said subject by pulmonary inhalation using a breath powered claim 5 , dry powder inhalation system.7. The dry powder pharmaceutical composition of claim 1 , wherein said prostaglandin is for treating moderate to severe pain.8. The dry powder pharmaceutical composition of claim 7 , wherein said prostaglandin comprises PG-I2 or an analog thereof.9. The dry powder pharmaceutical composition of claim 1 , wherein the dry powder pharmaceutical composition further comprises an aliphatic amino acid.10. The dry powder pharmaceutical composition of claim 9 , wherein ...

Herbicide/safener compositions containing n-(tetrazol-5-yl) aryl carboxylic acid amides and n-(triazol-5-yl) aryl carboxylic acid amides

Herbicide-safener compositions are described, comprising active herbicidal ingredients from the group of the N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides and safeners. These herbicide-safener compositions are particularly suitable for use against harmful plants in crops of useful plants.

System, computer-aided method and computer program product for generating structural parameters of a complex apparatus

A computer-aided method, based on at least one specification parameter, construction parameters are generated by a complex device by a trained neural network is provided. The neural network is trained based on reference data and operating data, wherein a non-insignificant part of the data is used for training from the iteration steps of the specialist. The reference data characterizes a plurality of complex devices which have been constructed or produced in the past and their respective at least one specification parameter and construction parameters thereof. The operating data characterizes the plurality of complex devices and their respective operating parameters which correspond to the respective construction parameters.

Diketopiperazine salts for drug delivery and related methods

Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization. 2. The method of claim 1 , wherein said step for removing said solvent comprises distillation.3. The method of claim 1 , wherein said step for removing said solvent comprises evaporation.4. The method of claim 1 , wherein said step for removing said solvent comprises spray drying.5. The method of claim 1 , wherein said step for removing said solvent comprises lyophilization.6. The method of claim 1 , wherein Rand Rare independently selected from 4-succinyl-am inobutyl claim 1 , 4-glutaryl-aminobutyl claim 1 , 4-maleyl-aminobutyl claim 1 , 4-fumaryl-aminobutyl claim 1 , 4-citraconyl-aminobutyl claim 1 , 4-malonyl-aminobutyl claim 1 , 4-oxalyl-aminobutyl.7. The method of claim 1 , wherein said at least one cation is selected from the group consisting of sodium claim 1 , potassium claim 1 , calcium claim 1 , magnesium claim 1 , lithium claim 1 , triethylamine claim 1 , butylamine claim 1 , diethanolamine claim 1 , and triethanolamine.8. The method of claim 1 , wherein said at least one cation is sodium.9. The method of claim 1 , wherein said biologically active agent is selected from the group consisting of hormones claim 1 , anticoagulants claim 1 , immunomodulating agents claim 1 , cytotoxic agents claim 1 , antibiotics claim 1 , antivirals claim 1 , antisense claim 1 , anti-inflammatories claim 1 , vasoactive agents claim 1 , neuroactive agents claim 1 , cannabinoids claim 1 , antigens claim 1 , antibodies and active fragments and analogues thereof.10. The method of further comprising ...

APPARATUS FOR DUAL CONNECTIVITY

Upon requesting an MME () to handover a UE () to a Target MeNB (_), a Source MeNB (_) sends, to the Target MeNB (_) through the MME (), information on one or more SeNBs that are candidates available for dual connectivity under control of the Target MeNB (_). The Target MeNB (_) configures a Target SeNB (_) that is selected based on the information to provide the dual connectivity. Alternatively, the Source MeNB (_) sends, to the Target MeNB (_), information on a Source SeNB (_) that has been used by the Source MeNB (_) for the dual connectivity. In this case, the Target MeNB (_) skips RRC configuration for the Source SeNB (_) upon the control. 1. A UE (User Equipment) comprising:a receiver configured to receive, from an MME (Mobility Management Entity) through an MeNB (Master eNB (evolved Node B)) to which the UE currently attaches for dual connectivity, a command to handover the UE to a different MeNB; anda processor configured to derive, by use of parameters included in the command, a security key that is used for securely communicating for the dual connectivity with an SeNB (Secondary eNB) under control of the different MeNB.2. The UE according to claim 1 , wherein the parameters include a counter and a KSI (Key Set Identifier).3. The UE according to claim 1 , wherein the receiver receives claim 1 , as the command claim 1 , an RRC (Radio Resource Control): Handover Command message.4. An MeNB that controls an SeNB to provide dual connectivity for a UE claim 1 , the MeNB comprising:a transmitter configured to send to an MME, upon requesting the MME to handover the UE to a different MeNB, first information on one or more SeNBs that are candidates available for the dual connectivity under control of the different MeNB.5. (canceled)6. The MeNB according to claim 4 ,wherein the transmitter forwards, from the MME to the UE, parameters necessary for the UE to derive a security key being used for securely communicating with an SeNB under control of the different MeNB.7. ...

KEY REFRESH FOR SMALL-DATA TRAFFIC

Apparatuses, methods, and systems are disclosed for key refresh triggering. One apparatus includes a transceiver and a processor that starts a counter corresponding to a UE having a small-data traffic pattern. In response to the transceiver receiving small-data traffic associated with the UE, the processor determines if a security key is valid based on a value of the counter. If the value of the counter indicates the security key is invalid, then the processor triggers a key refresh procedure. The processor relays the small-data traffic in response to the UE having a valid security key. 1. A method of a network function comprising:starting a counter corresponding to a remote unit having a small-data traffic pattern;receiving small-data traffic associated with the remote unit;determining if a security key is valid based on a value of the counter;triggering a key refresh procedure if the value of the counter indicates the security key is invalid; andrelaying the small-data traffic in response to the remote unit having a valid security key.2. The method of claim 1 , wherein receiving the small-data traffic comprises receiving a non-access stratum (“NAS”) message from the remote unit claim 1 , wherein the NAS message contains the small-data traffic.3. The method of claim 1 , wherein receiving the small-data traffic comprises receiving the small-data traffic from a session management function.4. The method of claim 1 , wherein the security key is a non-access stratum (“NAS”) key claim 1 , wherein triggering the key refresh procedure comprises one of: initiating a NAS security mode command (“SMC”) procedure and initiating a NAS key refresh procedure.5. The method of claim 1 , wherein the security key protects an air-interface between the remote unit and a base unit.6. The method of claim 1 , wherein the counter tracks an amount of time elapsed since the security key was issued.7. The method of claim 1 , wherein the counter tracks at least one of: a number of uplink ...

DEDICATED CORE NETWORKS (DCN) SELECTION

The invention provides for a method of selecting a Dedicated Core Network (DCN) based on assisting indication by mobile terminals, and including the step of configuring the RAN Nodes of the mobile network with the DCN Types of the serving EPC Nodes so that the RAN Nodes can map the DCN selection assisting information from the connecting mobile terminals with the right dedicated EPC Node. This allows for the RAN Node to connect the mobile terminals with EPC Node of the mobile terminal's dedication at initial attach and then keep the mobile terminals on the same DCN. Thus, a re-routing of mobile terminals NAS message from one EPC Node to another EPC node is avoided. The invention also allows for a flexible and dynamic change of the EPC Nodes dedication based on operator's configuration and policy. Additionally, the invention allows for DCN access restriction control by broadcasting of the supported DCN Types by the RAN Node. 1. A radio access network node comprising:a receiver configured to receive on a S1 interface from a core network node connected to the radio access network node a configuration update message of the core network node for configuring with at least one dedicated core network supported by the core network node;a memory storing instructions; andat least one processor configured to process the instructions to select one dedicated core network from the at least one dedicated core network.2. The radio access network node according to claim 1 , whereinthe configuration update message includes a list of types of the at least one dedicated core network, andthe at least one processor is further configured to process the instructions to select one core network node corresponding to the one dedicated core network, based on the list.3. The radio access network node according to claim 1 , further comprising:a further receiver configured to receive from a mobile terminal information for indicating a dedicated core network at registration to a new location in a ...

Operating head for an industrial truck

An operating head for an industrial truck comprises a support extending along a longitudinal axis and comprising opposing carrier sections. One or more gripping sections are positioned opposite each of the opposing carrier sections, wherein the opposing carrier sections and gripping sections at least partially define a handle opening. The operating head further comprises at least one operating element positioned on at least one of the opposing carrier sections. The at least one operating element comprises a cylindrical body extending along a cylindrical body axis and defining a bulge extending radially from the cylindrical body along a bulge axis. The bulge extends towards the one or more gripping sections when the at least one operating element is in a rest position and the at least one operating element is pivotable about the cylindrical body axis by exerting a force against the bulge.