System for the rendering of shared digital interfaces relative to each user's point of view

A head mounted device provides an immersive virtual or augmented reality experience for viewing data and enabling collaboration among multiple users. Rendering images in a virtual or augmented reality system may include capturing an image and spatial data with a body mounted camera and sensor array, receiving input indicating a first anchor surface, calculating parameters with respect to the body mounted camera and displaying a virtual object such that the virtual object appears anchored to the selected first anchor surface. Further rendering operations may include receiving a second input indicating a second anchor surface within the captured image that is different from the first anchor surface, calculating parameters with respect to the second anchor surface and displaying the virtual object such that the virtual object appears anchored to the selected second anchor surface and moved from the first anchor surface.

Flat box, tool, and method of dispensing drywall joint compound

Disclosed are flat boxes, tools, and methods for dispensing drywall joint compound, for example, into joints between sheets of drywall on a building interior surface or for finishing drywall. Various embodiments include a stopper or opening cover to block the opening to dispense the drywall joint compound, at least one guide that holds the opening cover substantially parallel to the back plate, holds the opening cover against the back plate, and allows the opening cover to slide along the back plate when moved by an operator of the flat box to block or unblock the opening to dispense the drywall joint compound, and a cover control mechanism that controls movement of the stopper or opening cover in relation to the back plate.

Bioengineered scaffolds for modulation of immune system and the uses thereof

The present invention provides compositions and methods that modulate the immune system in a subject.

Ct scan inflatable mattress

An inflatable mattress includes a top panel, a bottom panel, and a side panel coupled between a perimeter of the top panel and a perimeter of the bottom panel. The side panel defines a cutout sized and configured to receive a headrest therein. The top panel defines a fabric section extending over the cutout.

Reconfigurable circuit to emulate system critical paths

A circuit for monitoring and controlling a clock signal generated by a clock source in a microprocessor device may include a voltage divider network that provides a plurality of voltages, a selector device that receives the plurality of voltages and provides a scaled supply voltage and a scaled ground voltage from the plurality of voltages, and at least one delay element that receives the scaled supply voltage and the scaled ground voltage and generates a delayed pulse signal by applying a delay to each pulse of the clock signal. The delayed pulse signal may include a delay magnitude that is controllable by the scaled supply voltage and the scaled ground voltage, such that the delayed pulse signal is used to generate a frequency correction signal based on a variation to a supply voltage of the microprocessor. The frequency correction signal may then be applied to the clock source.

Extensibility of business logic shared across a business process orchestration engine, a rule engine, and a user interface

A method for codeless development of an application includes registering one or more actions in a registry. Each action is coded in a reusable block of code, each action having an action definition including an action type name, an input parameters map, and an output parameters map. The method further includes performing an action type name look up in the registry for an invoked action with an action service ensuring that a number of arguments included in the action definition matches a number of arguments specified by the action type, passing an input to and receiving a return value from the invoked action, updating the output parameters map included in the definition of the invoked action, and returning the updated output parameters map to an application in development for updating processing variables in the application.

Multi-Core Dynamic Frequency Control System

An approach is provided in which a multi-core processor's first core determines whether it controls a system frequency that drives a group of cores included in the multi-core processor. When the first core is not controlling the system frequency for the group of cores, the first core uses an internal voltage control module to provide control information to the first core's programmable voltage regulator and, in turn, independently control the first core's voltage level. When the first core is controlling the system frequency, the first core receives voltage control information from pervasive control to control the first core's voltage levels.

Colorimetric aerosol and gas detection for aerosol delivery device

The present disclosure relates to a colorimetric aerosol detection device for detecting target compounds in an aerosol generated from an aerosol delivery device. The colorimetric aerosol detection device includes a tubular housing with a first open end and a second open end such that a stream of vapor can pass through the tubular housing in a direction from the first end to the second end. The first open end is configured to engage a mouthpiece of the aerosol delivery device and the second open end is configured as a mouthpiece through which a user can draw a stream of vapor generated by the aerosol delivery device into the tubular housing by suction. A colorimetric indicator material is located inside the tubular housing configured to signal detection of a target compound in the vapor stream by a change in color visible to the user through a transparent or translucent portion of the tubular housing.

Methods and compositions for treating acute myeloid leukemia

The disclosure relates to compositions, methods, and kits for treating leukemia, specifically acute myeloid leukemia, in a subject, and for detecting chemoresistant acute myeloid leukemic cells.

Lateral transfer mattress and rotational positioning device

An inflatable transfer mattress includes a top panel, a bottom panel having a perimeter sealingly coupled to a perimeter of the top panel to define an internal volume therebetween, and a rotational positioning device coupled to the top panel. The internal volume is configured to receive an air flow therein. The rotational positioning device is positioned outside of the internal volume and includes at least one inflatable bladder configured to be inflated from a deflated state to an inflated state. The bladder portion is configured to rotate a patient to a predetermined angle with respect to the top panel in the inflated state.

Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs

Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly steroids, are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid; a solubilizer, preferably a vitamin E substance; and a surfactant. The synergistic effect between the hydrophobic drug and the vitamin E substance results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharmaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided.

Methods and assays relating to circulating tumor cells

The technology described herein relates to methods of detecting circulating tumor cells (CTCs), e.g. by detecting changes in the expression of certain CTC marker genes. Aberrant expression of CTC marker genes, e.g. changes in expression indicative of CTCs can also be targeted in order to treat cancer.

Systems and methods for percutaneous access and formation of arteriovenous fistulas

A device and method for creating an arteriovenous (AV) fistula includes a proximal base having a distal diagonal end surface and a distal tip connected to the proximal base and movable relative to the proximal base. The distal tip has a proximal diagonal end surface. A heating assembly, including an energized heating element, is disposed one of the distal diagonal end surface and the proximal diagonal end surface. A passive heating assembly is disposed on the mating diagonal end surface. The distal diagonal end surface and the proximal diagonal end surface are adapted to contact opposing sides of a tissue portion to create a fistula. The angle of the proximal diagonal end surface matches the angle of the distal diagonal end surface, so that the two surfaces match one another during deployment.

Data Analysis for an Implantable Restriction Device and a Data Logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

Gui With Trend Analysis for an Implantable Restriction Device and a Data Logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

Physiological parameter analysis for an implantable restriction device and a data logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

GUI for an implantable restriction device and a data logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

Preparation of polyamide block copolymers

This invention relates to the preparation of polyamide block copolymers by sequential monomer addition. More particularly, it relates to catalysts capable of copolymerizing not only cyclic amides, but other monomers such as cyclic esters and epoxides as well, using sequential addition so as to produce useful and novel block copolymers.

Compositions and methods for administering pneumococcal dna

Plasmid DNA encoding at least one pneumococcal antigen or epitope of interest and methods for making and using such a plasmid are disclosed and claimed. The epitope of interest can be PspA or a fragment thereof. Compositions containing the plasmid DNA are useful for administration to a host susceptible to pneumococcal infection for an in vivo response, such as a protective response, or for generating useful antibodies. The inventive plasmid can also be transfected into cells for generating antigens or epitopes of interest in vitro. The inventive plasmid can be prepared by isolating DNA (coding for: promoter, leader sequence, epitope of interest and terminator), and performing a three-way ligation. More particularly, administration of DNA encoding pneumococcal antigens or epitopes of interest and compositions therefor for eliciting and immunological response against S. pneumoniae, such as a protective response preventive of pneumococcal infection, are disclosed and claimed. Thus, pneumococcal vaccines or immunological compositions, and methods of making and using them, are disclosed and claimed.

Thermally-activated coupling arrangements and methods for attaching tools to ultrasonic surgical instruments

An ultrasonic surgical instrument that has a waveguide that protrudes distally from the handpiece and a surgical tool that is configured to be coupled to the waveguide upon application of thermal energy to the waveguide or the surgical tool.

high density polyethylene composition, method for producing a high density polyethylene composition, article, bottle cap closure, method for improving bottle cap closures, and method for producing an article

COMPOSIçAO DE POLIETILENO DE ALTA DENSIDADE, METODO PARA PRODUZIR UMA COMPOSIçAO DE POLIETILENO DE ALTA DENSIDADE, ARTIGO, FECHAMENTO DE TAMPA DE GARRAFA, MéTODO PARA MELHORAR FECHAMENTOS DE TAMPAS DE GARRAFAS, E MéTODO PARA PRODUZIR UM ARTIGO A presente invenção é uma composição de polietileno de alta densidade, método de preparar a mesma, artigos confeccionados a partir dela, e método para confeccionar tais artigos. A composição de polietileno de alta densidade da presente invenção inclui um primeiro componente e um segundo componente. O primeiro componente é um copolímero de etileno/alfa-olefina de alto peso molecular tendo uma densidade na faixa de 0,915 a 0,940 g/cm3, e um índice de fusão (I21,6)na faixa de 0,5 a 10 g/10 minutos. O segundo componente é um polímero de etileno de baixo peso molecular tendo uma densidade na faixa de 0,965 a 0,980 g/cm3, e um índice de fusão (i2)na faixa de 50 a 1500 g/10 minutos. A composição de polietileno de alta densidade tem um índice de fusão (i2)depelo menos 1, uma densidade na faixa de 0,950 a 0,960 g/cm3, e g' maior ou igual a 1. O método para produzir uma composição de polietileno de alta densidade inclui as seguintes etapas: (1) introduzir etileno, e um ou mais comonómeros de alfa-olefina num primeiro reator; (2) HIGH DENSITY POLYETHYLENE COMPOSITION, METHOD TO PRODUCE HIGH DENSITY POLYETHYLENE COMPOSITION, ARTICLE, BOTTLE CLOSURE CLOSURE, METHOD TO IMPROVE BOTTLE CLOSES, AND A PRODUCT OF A BODY PRODUCT high density, method of preparing same, articles made from it, and method for making such articles. The high density polyethylene composition of the present invention includes a first component and a second component. The first component is a high molecular weight ethylene / alpha-olefin copolymer having a density in the range of 0.915 to 0.940 g / cm3, and a melt index (I21.6) in the range of 0.5 to 10 g / 10. minutes The second component is a low molecular weight ethylene polymer having a density in the range of 0. ...

Physiological Parameter Analysis for an Implantable Restriction Device and a Data Logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

Implantable restriction system with release mechanism

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A release mechanism is provided for the tension element.

Implantable restriction system tension release mechanism

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A tension release mechanism is associated with the tension element.

Tissue interface for implantable restriction system

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. The elongated member has a compressible ventral surface and a substantially rigid dorsal periphery, wherein the elongated member includes a fluid bladder positioned along the ventral surface. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. Alternate embodiments are also disclosed.

Symmetrical drive system for an implantable restriction device

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A symmetrical drive system including a drive element associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct is further provided. In accordance with an alternate embodiment an apparatus for regulating the functioning of a patient's organ or duct including an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. The tension element is composed of a flexible first member and a flexible second member, wherein the flexible first member is movable relative to the flexible second member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct.

GUI for an Implantable Restriction Device and a Data Logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

Implantable restriction device with protective member

An implantable restriction device includes a belt and a balloon secured to the belt for engagement with tissue when the implantable restriction device is positioned about an organ. A protective member is associated with the balloon for positioning between the balloon and a tissue surface defining a band tissue interface.

Data analysis for an implantable restriction device and a data logger

A symmetrical drive system for an implantable restriction device

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A symmetrical drive system including a drive element associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct is further provided. In accordance with an alternate embodiment an apparatus for regulating the functioning of a patient's organ or duct including an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. The tension element is composed of a flexible first member and a flexible second member, wherein the flexible first member is movable relative to the flexible second member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct.

Tissue interface for implantable restriction system

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. The elongated member has a compressible ventral surface and a substantially rigid dorsal periphery, wherein the elongated member includes a fluid bladder positioned along the ventral surface. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. Alternate embodiments are also disclosed.

Implantable restriction system with release mechanism

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element (32) is disposed for movement within the elongated member. A drive element is associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A release mechanism (312) is provided for the tension element.

Implantable restriction system tension release mechanism

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A tension release mechanism is associated with the tension element.

Tissue interface for implantable restriction system

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. The elongated member has a compressible ventral surface and a substantially rigid dorsal periphery, wherein the elongated member includes a fluid bladder positioned along the ventral surface. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. Alternate embodiments are also disclosed.

Implantable restriction system tension release mechanism

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member (22) having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element (32) is disposed for movement within the elongated member. A drive element (576,578) is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A tension release mechanism (574) is associated with the tension element.

Implantable restriction system with release mechanism

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A release mechanism is provided for the tension element.

Symmetrical drive system for an implantable restriction device

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A symmetrical drive system including a drive element associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct is further provided. In accordance with an alternate embodiment an apparatus for regulating the functioning of a patient's organ or duct including an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. The tension element is composed of a flexible first member and a flexible second member, wherein the flexible first member is movable relative to the flexible second member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct.

Data analysis for an implantable restriction device and a data logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

GUI with trend analysis for an implantable restriction device and a data logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

Physiological parameter analysis for an implantable restriction device and a data logger

GUI with trend analysis for an implantable restriction device and a data logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

Physiological parameter analysis for an implantable restriction device and a data logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

Gui an implantable restriction device and a data logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

GUI for an implantable restriction device and a data logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

Gui an implantable restriction device and a data logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

GUI for an implantable restriction device and a data logger

An implantable restriction device can be configured to provide a restriction in a patient, for example as a function of the pressure of fluid. The implantable restriction device can include one or more sensors configured to sense a variety of parameters, such as pressure of the fluid within the implantable restriction device, pulse width, pulse amplitude, pulse count, pulse duration, or frequency, electrical characteristics, or other parameters. Data obtained by the one or more sensors (for example, the data representing pressure, pulse characteristics, and so on) may be communicated to a device located external to the patient, such as a data logger, using telemetry coils or other communicators. The data logger may store the data, and may communicate the data to a remote location via a network such as the Internet. A docking station may be provided to couple the data logger to a network and/or to recharge a cell in the data logger. The logged data may be analyzed and/or displayed using a variety of techniques to assess and/or track the condition of the restriction device or of the patient, to monitor patient physiology, or for other purposes.

Implantable restriction system tension release mechanism

An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member (22) having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element (32) is disposed for movement within the elongated member. A drive element (576,578) is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A tension release mechanism (574) is associated with the tension element.

Human anti-epidermal growth factor receptor single-chain antibodies

Human anti-epidermal growth factor receptor (EGFR) single-chain antibodies (scFvs) were isolated from a human IgM phage display library using purified epidermal growth factor receptor as antigen. Two isolates with different amino acid sequences were identified by ELISA as epidermal growth factor receptor-specific. the scFvs bind to the full length epidermal growth factor receptor and the truncated and/or mutated epidermal growth factor receptor on human cells. These anti-EGFR-scFvs are useful as therapeutic and/or diagnostic agents.

Low sparkle matte coats and methods of making

A matte coat having a first major surface, the matte coat comprising a first layer defining the first major face of the matte coat and comprising a polymeric matrix and a plurality of forming bodies entrained therein, wherein index of refraction of the forming bodies is similar to that of the polymeric matrix and the first major surface has a plurality of protuberances corresponding to forming bodies entrained within. Also, optical assemblies comprising such matte coats and methods for making such matte coats.

Low sparkle matte coats and methods of making

A matte coat having a first major surface, the matte coat comprising a first layer defining the first major face of the matte coat and comprising a polymeric matrix and a plurality of forming bodies entrained therein, wherein index of refraction of the forming bodies is similar to that of the polymeric matrix and the first major surface has a plurality of protuberances corresponding to forming bodies entrained within. Also, optical assemblies comprising such matte coats and methods for making such matte coats.

L AND MANUFACTURING METHOD THEREFOR

High-density polyethylene compositions, method of making the same, articles made therefrom, and method of making such articles

The instant invention is a high-density polyethylene composition, method of producing the same, articles made therefrom, and method of making such articles. The high- density polyethylene composition of the instant invention includes a first component, and a second component. The first component is a high molecular weight ethylene alpha-olefin copolymer having a density in the range of 0.915 to 0.940 g/cm3, and a melt index (I21.6) in the range of 0.5 to 10 g/10 minutes. The second component is a low molecular weight ethylene polymer having a density in the range of 0.965 to 0.980 g/cm3, and a melt index (I2) in the range of 50 to 1500 g/10 minutes. The high-density polyethylene composition has a melt index (I2) of at least 1, a density in the range of (I2) in the range of 0, 950 to 0,960g/cm3, and g' of equal or greater than 1. The method of producing a high-density polyethylene composition includes the following steps: (1) introducing ethylene, and one or more alpha-olefin comonomers into a first reactor; (2) (co)polymerizing the ethylene in the presence of one or more alpha-olefin comonomers in the first reactor thereby producing a first component, wherein the first component being a high molecular weight ethylene alpha-olefin copolymer having a density in the range of 0.915 to 0.940 g/cm3, and a melt index (I21.6) in the range of 0.5 to 10 g/10 minutes; (3) introducing the first component and additional ethylene into a second reactor; (4) polymerizing the additional ethylene in the second reactor thereby producing a second component, wherein the second component being a low molecular weight ethylene polymer having a density in the range of 0.965 to 0.980 g/cm3, and a melt index (I2) in the range of 50 to 1500 g/10 minutes; and (5) thereby producing the high-density polyethylene composition, wherein the high-density polyethylene composition having a melt index (I2) of at least 1, a density in the range of 0.950 to 0.960 g/cm3, and g' of equal or greater ...

MULTILAYER THERMOPLASTIC FILM WITH IMPROVED PUNCH RESISTANCE PERFORMANCE

La presente divulgación proporciona una película termoplástica multicapa, termorretrátil, estirada biaxialmente que incluye al menos una capa resistente a la perforación. La capa resistente a la perforación se forma con un plastómero a base de polietileno que tiene una densidad de 0,890 g/cm³ a 0,910 g/cm³ según se mide de acuerdo con ASTM D-792 y un índice de fusión (MI) según se mide a través de ASTM D-1238 a 190ºC/2,16 kg de 0,20 g/10 minutos a 1,5 g/10 minutos. El plastómero a base de polietileno tiene un logM₂₅% de un 25% superior de un cuadrante de GPC que tiene un valor de 5,1 a 5,7, una distribución de peso molecular intermedio (Mʷ/Mₙ) de 2,5 a 3, un valor de Mᶻ/Mʷ de 2 a 2,5, un valor de la constante de distribución de comonómeros de 60 a 400 y un solo pico de SCBD entre 40 - 85ºC con una fracción de masa de menos de 3% por encima de 85ºC según se determina por CEF y un valor de ZSVR de 1,0 a 5,5. La película termoplástica multicapa se estira biaxialmente a una temperatura de 60ºC a 120ºC con una relación de soplado de 2:1 a 10:1. The present disclosure provides a biaxially stretched, heat shrinkable, multilayer thermoplastic film that includes at least one puncture resistant layer. The puncture resistant layer is formed of a polyethylene-based plastomer having a density of 0.890 g / cm³ to 0.910 g / cm³ as measured in accordance with ASTM D-792 and a melt index (MI) as measured. through ASTM D-1238 at 190 ° C / 2.16 kg from 0.20 g / 10 minutes to 1.5 g / 10 minutes. The polyethylene-based plastomer has a logM₂₅% of the top 25% of a GPC quadrant having a value of 5.1 to 5.7, an intermediate molecular weight distribution (Mʷ / Mₙ) of 2.5 to 3 , a Mᶻ / Mʷ value of 2 to 2.5, a comonomer distribution constant value of 60 to 400, and a single SCBD peak between 40 - 85 ° C with a mass fraction of less than 3% above 85 ° C as determined by CEF and a ZSVR value of 1.0 to 5.5. The multilayer thermoplastic film is stretched biaxially at a temperature of 60 ° C to 120 ...

ethylene homopolymer or copolymer and free radical initiation polymerization process

homopolímero ou copolímero de etileno e processo de polimerização com iniciação via radicais livres. a presente invenção refere-se a um homopolímero ou copolímero de etileno caracterizado por ter ramificação de cadeia longa, e ter uma distribuição de peso molecular, mw/mn, e uma gpc-lalls cdf, que satisfaz a seguinte relação: y <242> 0,0663x - 0,015, na qual y= gpc- lalls cdf e x= mw/mn medido por gpc convencional, uma linha traçada de onde o cromatograma de ls cruza com peso molecular 350.000 e peso molecular 1.150.000 ter uma inclinação positiva, preferivelmente com um índice de fusão entre 0,15 e 2000 g/10 minutos. além disso, a invenção refere-se a um processo de polimerização com iniciação via radicais livres para a preparação de polímeros ou copolímeros de etileno compreendendo reagir etileno e opcionalmente um ou mais comonômeros numa pressão elevada, convenientemente entre 13.000 psig e 100.000 psig, e em temperaturas de reator de 115 °c a 400 °c, preferivelmente 125-400 °c, mais preferivelmente 140-350 °c, especialmente 165-320 °c, num sistema de reatores compreendendo pelo menos um reator tubular, e pelo menos um reator autoclave, sendo que a alimentação de monômeros nos reatores é dividida em múltiplas correntes de alimentação de monômeros, e sendo que pelo menos uma corrente de alimentação de monômeros no reator tubular consiste essencialmente de monâmero não reagido. ethylene homopolymer or copolymer and free radical initiation polymerization process. The present invention relates to an ethylene homopolymer or copolymer characterized in that it has long chain branching, and has a molecular weight distribution, mw / mn, and a gpc-lalls cdf, which have the following relationship: y <242> 0.0663x - 0.015, where y = gpc-lalls cdf ex = mw / mn measured by conventional gpc, a line drawn from where the ls chromatogram intersects with 350,000 molecular weight and 1,150,000 molecular weight have a positive slope, preferably with a melt index between ...

Process for producing low density polyethylene compositions and polymers produced therefrom

Compositions and methods for administering pneumococcal dna

Plasmid DNA encoding at least one pneumococcal antigen or epitope of interest and methods for making and using such a plasmid are disclosed and claimed. The epitope of interest can be PspA or a fragment thereof. Compositions containing the plasmid DNA are useful for administration to a host susceptible to pneumococcal infection for an in vivo response, such as a protective response, or for generating useful antibodies. The inventive plasmid can also be transfected into cells for generating antigens or epitopes of interest in vitro. The inventive plasmid can be prepared by isolating DNA (coding for: promoter, leader sequence, epitope of interest and terminator), and performing a three-way ligation. More particularly, administration of DNA encoding pneumococcal antigens or epitopes of interest and compositions therefor for eliciting and immunological response against S. pneumoniae, such as a protective response preventive of pneumococcal infection, are disclosed and claimed. Thus, pneumococcal vaccines or immunological compositions, and methods of making and using them, are disclosed and claimed.

Compositions and methods for administering pneumococcal dna

Plasmid DNA encoding at least one pneumococcal antigen or epitope of interest and methods for making and using such a plasmid are disclosed and claimed. The epitope of interest can be PspA or a fragment thereof. Compositions containing the plasmid DNA are useful for administration to a host susceptible to pneumococcal infection for an in vivo response, such as a protective response, or for generating useful antibodies. The inventive plasmid can also be transfected into cells for generating antigens or epitopes of interest in vitro. The inventive plasmid can be prepared by isolating DNA (coding for: promoter, leader sequence, epitope of interest and terminator), and performing a three-way ligation. More particularly, administration of DNA encoding pneumococcal antigens or epitopes of interest and compositions therefor for eliciting and immunological response against S. pneumoniae, such as a protective response preventive of pneumococcal infection, are disclosed and claimed. Thus, pneumococcal vaccines or immunological compositions, and methods of making and using them, are disclosed and claimed.

由聚合物配方所製備之薄膜層

ethylene polymer composition and molded article

COMPOSIçãO DE POLIMERO DE ETILENO E ARTIGO MOLDADO A invenção provê composições para aplicações de moldagema sopro e outras aplicações, em que tais composições compreendem um polímero de etileno de alta densidade e um polímero de etileno de alto peso molecular. Nessas composições, o polímero de etileno de alta densidade possui uma densidade maior que a densidade do polímero de etileno de alto peso molecular, e o polímero de etileno de alto peso molecular possui um peso molecular médio ponderal maior do que o peso molecular médio ponderal do polímero de etileno de alta densidade, e além disso, o polímero de etileno de alta densidade possui uma densidade de 0,94 91cm3 a 0,98 91cm^ 3^, e uma distribuição de peso molecular, Mw/Mn, maior que 8, e o polímero de etileno de alto peso molecular possui um peso molecular médio ponderal maior que 200.000 g/mol e uma relação de peso molecular, Mz/Mw, inferior a 5. ETHYLENE POLYMER COMPOSITION AND MOLDED ARTICLE The invention provides compositions for blow molding applications and other applications, wherein such compositions comprise a high density ethylene polymer and a high molecular weight ethylene polymer. In these compositions, the high density ethylene polymer has a density greater than the density of the high molecular weight ethylene polymer, and the high molecular weight ethylene polymer has a weight average molecular weight greater than the weight average molecular weight of high density ethylene polymer, and in addition, the high density ethylene polymer has a density of 0.94 91cm3 to 0.98 91cm ^ 3 ^, and a molecular weight distribution, Mw / Mn, greater than 8, and the high molecular weight ethylene polymer has a weight average molecular weight greater than 200,000 g / mol and a molecular weight ratio, Mz / Mw, less than 5.

Ethylene-based polymers with good processability for use in multilayer films

Una composición que comprende un polímero basado en etileno que comprende las siguientes propiedades: a) Distribución de Peso Molecular (MWD (conv)) de 3,0 a 7,0 medida según Cromatografía de Permeabilidad de Gel convencional (GPC); b) una Fracción de Detector de Área de infrarrojos (ADF IR) de 0,230 a 0,260 para un peso molecular <= 15.000 g/mol medido según GPC usando un detector de infrarrojos; c) un índice de fluidez (I2) de 4,0 a 6,5 g/10 min medido de acuerdo con ASTM D 1238-10, Condición 190 °C/2,16 kg, Procedimiento B. A composition comprising an ethylene-based polymer comprising the following properties: a) Molecular Weight Distribution (MWD(conv)) of 3.0 to 7.0 as measured by conventional Gel Permeability Chromatography (GPC); b) an infrared Area Detector Fraction (IR ADF) of 0.230 to 0.260 for a molecular weight <= 15,000 g/mol measured by GPC using an infrared detector; c) a Melt Flow Index (I2) of 4.0 to 6.5 g/10 min measured in accordance with ASTM D 1238-10, Condition 190 °C/2.16 kg, Procedure B.

A NON-WOVEN FABRIC THAT HAS ETHYLENE / a-OLEFIN POLYMER FIBERS

Una tela no tejida que comprende al menos una fibra que tiene un primer componente preparado a partir de al menos 75% en peso de una composición de interpolímero bimodal de etileno / a-olefina, en donde la composición de interpolímero de etileno / a-olefina se caracteriza por: una densidad en el rango de 0,930 a 0,965 g/cm³, un índice de fusión (I₂) en el rango de 10 a 60 g/10 minutos, en donde el I₂ se mide de acuerdo con ASTM D1238, 190ºC, 2,16 kg, una distribución de peso molecular, expresada como la relación del peso molecular promedio en peso con respecto al peso molecular promedio en número (Mʷ₍GPC₎/Mₙ₍GPC₎), según lo determinado por GPC, en el rango de 1,5 a 2,6, una tangente d a 1 radian/segundo de al menos 45, un pico de baja temperatura y un pico de alta temperatura en un perfil de elución mediante un procedimiento de distribución mejorada de composición de comonómero (ICCD), y un ancho completo a la mitad del máximo del pico de alta temperatura es menor de 6,0ºC. A nonwoven fabric comprising at least one fiber having a first component prepared from at least 75% by weight of a bimodal ethylene / α-olefin interpolymer composition, wherein the ethylene / α-olefin interpolymer composition It is characterized by: a density in the range of 0.930 to 0.965 g / cm³, a melt index (I₂) in the range of 10 to 60 g / 10 minutes, where the I₂ is measured according to ASTM D1238, 190ºC, 2.16 kg, a molecular weight distribution, expressed as the ratio of weight average molecular weight to number average molecular weight (Mʷ₍GPC₎ / Mₙ₍GPC₎), as determined by GPC, in the range 1.5 to 2.6, a 1 radian / second tangent of at least 45, a low temperature peak and a high temperature peak in an elution profile using an enhanced comonomer composition distribution (ICCD) procedure , and a full width at half the maximum of the high temperature peak is less than 6.0 ° C.

Release article and adhesive article comprising the release article

A release article comprising a substrate having a release material thereon, wherein the release material comprises a polymer comprising an olefin and an alkyl (meth)acrylate, wherein the polymer has (a) an alkyl (meth)acrylate content of about 20 to about 50 weight % based on a total weight of the release material and the alkyl (meth)acrylate has an alkyl group with a carbon number from 2 to 30 or (b) an alkyl (meth)acrylate content of about 25 to about 50 weight % based on the total weight of the release material and the alkyl (meth)acrylate has an alkyl group with a carbon number from 1 to 30, and an adhesive article incorporating the release article.

Compositions of polyesters and sepiolite-type clays

Compositions of thermoplastic polyesters and sepiolite-type clay in which the clay is dispersed in the polyester as often fibrous particles whose smallest dimension is less than 100 nm are made by polymerizing the polyester precursors in the presence of the clay. The compositions have good physical properties and can be melt molded into various articles. Many of these articles may be coated (painted) and are especially useful for appearance parts such as visible exterior automotive body parts.

HIGH DENSITY POLYETHYLENE COMPOSITIONS, METHOD FOR THE PRODUCTION THEREOF, ARTICLES MANUFACTURED THEREFROM AND METHOD FOR PRODUCING SUCH ITEMS

Methods for modulating protein function in cells using, intracellular antibody homologues

Methods and compositions for modulating protein function in a cell involving intracellular expression of an antibody homologue that binds to the protein within the cell are disclosed. In a preferred embodiment, an antibody homologue, such as a single chain Fv (sFv) fragment, is expressed within an intracellular compartment of a cell, such as the endoplasmic reticulum (ER), to inhibit cell surface expression of a membrane protein. Preferably, the cell is a malignant mammalian cell and the protein is a cell surface receptor oncoprotein, such as c-erbB2. Intracellular binding of the antibody homologue to the receptor oncoprotein inhibits its surface expression and, moreover, inhibits cell proliferation and cell survival. Isolated nucleic acid molecules encoding anti-c-erbB2 antibody homologues, as well as recombinant expression vectors and host cells incorporating these nucleic acid molecules, are also disclosed.

High-density polyethylene compositions, method of making the same, articles made therefrom, and method of making such articles

Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same

A substrate is coated with a polyvinylpyrollidone-polyurethane interpolymer. In the method, a polyisocyanate and a polyurethane in a solvent such as methyl ethyl ketone are applied to a substrate and the solvent evaporated. If the substrate is a polyurethane, only the polyisocyanate need be employed. Polyvinylpyrollidone in a solvent is then applied to the treated substrate and the solvent evaporated. The invention is applied, for example, to a tube such as a catheter, a condom and a peristaltic pump tube.

Coupling arrangements and methods for attaching tools to ultrasonic surgical instruments

An ultrasonic surgical instrument that has a waveguide that protrudes distally from the handpiece and a surgical tool that is configured to be coupled to the waveguide. The waveguide may have a distal end that is sized to be inserted into a cavity in a proximal end of the surgical tool and then selectively expanded to retain the distal end within the cavity to couple the surgical tool to the waveguide.

Coupling arrangements and methods for attaching tools to ultrasonic surgical instruments

An ultrasonic surgical instrument that has a waveguide that protrudes distally from the handpiece and a surgical tool that is configured to be coupled to the waveguide. The waveguide may have a distal end that is sized to be inserted into a cavity in a proximal end of the surgical tool and then selectively expanded to retain the distal end within the cavity to couple the surgical tool to the waveguide.

Coupling arrangements and methods for attaching tools to ultrasonic surgical instruments

An ultrasonic surgical instrument that has a waveguide that protrudes distally from the handpiece and a surgical tool that is configured to be coupled to the waveguide. The waveguide may have a distal end that is sized to be inserted into a cavity in a proximal end of the surgical tool and then selectively expanded to retain the distal end within the cavity to couple the surgical tool to the waveguide.

Coupling arrangements and methods for attaching tools to ultrasonic surgical instruments

An ultrasonic surgical instrument that has a waveguide that protrudes distally from the handpiece and a surgical tool that is configured to be coupled to the waveguide. The waveguide may have a distal end that is sized to be inserted into a cavity in a proximal end of the surgical tool and then selectively expanded to retain the distal end within the cavity to couple the surgical tool to the waveguide.

Dual wiper mascara package having residual chamber with bypass channel

A cosmetic product package, particularly a mascara package, including a dual wiper mechanism which virtually eliminates the messiness problems of typical mascara applicators. The dual wiper mechanism has a resilient inner wiper and a resilient outer wiper spaced apart from one another within a supporting structure forming a residual mascara chamber therebetween. The inner wiper has a relatively small opening which provides most of the doctoring of the bristles. The outer wiper has a larger opening which primarily doctors the stem. Mascara which collects in the residual chamber flows through conduits around the inner wiper back into the primary reservoir, or alternatively to a discard reservoir. A mechanism to doctor more mascara from the brush upon insertion than upon removal of the brush may also be provided.

Aerosol delivery device including a wirelessly-heated atomizer and related method

The present disclosure relates to an aerosol delivery device configured to wirelessly heat an atomizer. The aerosol delivery device may include a control body and a cartridge. The control body may include an induction transmitter. The cartridge may include an induction receiver and an aerosol precursor composition. When electrical current is directed to the induction transmitter, the induction receiver may be inductively heated. The heat produced by the induction receiver may form an aerosol from the aerosol precursor composition at the substrate. Related methods are also provided.

Noninvasive genetic immunization, expression products therefrom and uses thereof

Disclosed and claimed are methods of non-invasive genetic immunization in an animal and/or methods of inducing a systemic immune or therapeutic response in an animal, products therefrom and uses for the methods and products therefrom. The methods can include contacting skin of the animal with a vector in an amount effective to induce the systemic immune or therapeutic response in the animal. The vector can include and express an exogenous nucleic acid molecule encoding an epitope or gene product of interest. The systemic immune response can be to or from the epitope or gene product. The nucleic acid molecule can encode an epitope of interest and/or an antigen of interest and/or a nucleic acid molecule that stimulates and/or modulates an immunological response and/or stimulates and/or modulates expression, e.g., transcription and/or translation, such as transcription and/or translation of an endogenous and/or exogenous nucleic acid molecule; e.g., one or more of influenza hemagglutinin, influenza nuclear protein, tetanus toxin C-fragment, anthrax protective antigen, HIV gp 120, human carcinoembryonic antigen, and/or a therapeutic, an immunomodulatory gene, such as co-stimulatory gene and/or a cytokine gene. The immune response can be induced by the vector expressing the nucleic acid molecule in the animal's cells. The immune response can be against a pathogen or a neoplasm. A prophylactic vaccine or a therapeutic vaccine or an immunological composition can include the vector.

Conjugates for introducing nucleic acid into higher eucaryotic cells

Conjugates in which a virus is bound via an antibody to a substance having an affinity for nucleic acid, for transporting gene constructs into higher eucaryotic cells. Complexes of the conjugates and nucleic acid are internalized in the cell, whilst the virus as part of the complex brings about the internalization and the release of the contents of the endosomes, in which the complexes are located after entering the cell. Pharmaceutical preparations in which the nucleic acid is a therapeutically active gene construct, particularly for use in gene therapy.

Dual staple cartridge for surgical stapler

A surgical stapler includes and end effector configured to receive an upper staple cartridge and a lower staple cartridge. The lower staple cartridge includes staple drivers disposed at a non-perpendicular or oblique angle. The staple drivers may be oppositely angled relative to the perpendicular. The staple drivers may further be coupled to an actuation member that pivots the staple drivers to the perpendicular prior to stapling. The actuation members may be actuated by the firing bar and/or by a wedge sled. The upper staple cartridge may also include angled staple drivers that are pivotable to the perpendicular. The upper staple cartridge and/or the lower staple cartridge may also include staple forming pockets. Alternatively, one staple driver may be perpendicular and second staple driver may be at a non-perpendicular angle. The second staple driver may be actuated into an angled stamped recess.

Methods for modulating protein function in cells using intracellular antibody homologues

Methods and compositions for modulating protein function in a cell involving intracellular expression of an antibody homologue that binds to the protein within the cell are disclosed. In a preferred embodiment, an antibody homologue, such as a single chain Fv (sFv) fragment, is expressed within an intracellular compartment of a cell, such as the endoplasmic reticulum (ER), to inhibit cell surface expression of a membrane protein. Preferably, the cell is a malignant mammalian cell and the protein is a cell surface receptor oncoprotein, such as c-erbB2. Intracellular binding of the antibody homologue to the receptor oncoprotein inhibits its surface expression and, moreover, inhibits cell proliferation and cell survival. Isolated nucleic acid molecules encoding anti-c-erbB2 antibody homologues, as well as recombinant expression vectors and host cells incorporating these nucleic acid molecules, are also disclosed.

Pedicle screw system configured to receive a straight or a curved rod

Apparatus for densification of porous billets

A porous preform is densified by heating while emersed in a precursor liquid. Heating is achieved by passing a current through the preform or by an induction coil immersed in the liquid. Ways to control the densification process are also described.

Compartmentalized waiter tray

A compartmentalized waiter tray comprised of a light weight, hand carried device which functions in conjunction with a plurality of drink receptacles, or other glasses, removably retained within a plurality of compartments of an industry standard dishwashing rack to provide a quick and easy method for transporting the glasses without subsequent drink receptacle migration due to gravity and inertia and to position the drink receptacles for filling with ice or fluent drinking matter of both via automatic or semi-automatic methods; and the compartmentalized waiter tray is formed with a plurality of compartments extending above the upper surface of the tray in a pre-defined pattern to match the pre-defined pattern which the plurality of drink receptacles occupy within a plurality of compartments of the industry standard dishwashing rack; the plurality of compartments of the compartmentalized waiter tray further comprising an upper surface, internal partitions (which extend upward less than one quarter of the height of the drink receptacle and) align with the internal partitions of the industry standard dishwashing rack and are raised to a lower level than the perimeter partitions which (extend less than one half of the height of the drink receptacle and) surround the outside perimeter partitions of the industry standard dishwashing rack which align the plurality of drink receptacles with the plurality of compartments within the compartmentalized waiter tray, and a refuse bin defined by the upper surface, the raised bevelled edge, and the perimeter partitions to contain debris found within the drink receptacles after they have been used.

Non-aqueous poly(urethane-urea)

Disclosed herein is a poly(urethane-urea) which is prepared by reverse-addition of an isocyanate-terminated prepolymer to an organic medium containing an alcoholic solvent and a chain extender comprising at least two isocyanate-reactive active hydrogen groups consisting essentially of amino groups.

Method of selecting pluripotent hematopioetic progenitor cells

Methods of selecting a population of human cells containing quiescent pluripotent hematopoietic progenitor cells substantially free of mature, human myeloid and lymphoid cells, the quiescent pluripotent progenitor cells obtained by these methods, and methods of using the pluripotent progenitor cells are described.

Interleukin-6 inhibitor

An altered antibody comprising scFv and Fc. In the altered antibody, variable regions of L chain and H chain are expressed as a single strand as scFv. The altered antibody can be expressed as a polypeptide of single strand further containing an Fc region. The altered antibody is a vector of simple construction and realizes reemergence of a structure imitating natural IgG. The polynucleotide coding for this altered antibody can be utilized as a vector for genetic therapy that is used to attain in vivo expression of an antibody molecule useful as especially an IL-6 receptor inhibitor.

Dual staple cartridge for surgical stapler

A surgical stapler includes and end effector configured to receive an upper staple cartridge and a lower staple cartridge. The lower staple cartridge includes staple drivers disposed at a non-perpendicular or oblique angle. The staple drivers may be oppositely angled relative to the perpendicular. The staple drivers may further be coupled to an actuation member that pivots the staple drivers to the perpendicular prior to stapling. The actuation members may be actuated by the firing bar and/or by a wedge sled. The upper staple cartridge may also include angled staple drivers that are pivotable to the perpendicular. The upper staple cartridge and/or the lower staple cartridge may also include staple forming pockets. Alternatively, one staple driver may be perpendicular and second staple driver may be at a non-perpendicular angle. The second staple driver may be actuated into an angled stamped recess.

Protein tyrosine kinases named rse

The receptor protein tyrosine kinase (rPTK) designed Rse has been identified from human and murine cell tissues. DNA encoding Rse rPTK has been cloned from a cDNA library of a human liver carcinoma cell Line (i.e., Hep 3B) using PCR amplification. Provided herein is nucleic acid encoding Rse rPTK useful as a diagnostic and in the recombinant preparation of Rse rPTK. Rse rPTK is used in the preparation and purification of antibodies thereto and in diagnostic assays.

AIDS DETECTION ASSEMBLY, METHOD FOR DETERMINING AIDS RISKS AND THERAPEUTIC COMPOSITION AGAINST THE SAME

L'INVENTION CONCERNE UN ENSEMBLE OU TROUSSE DE REACTIFS POUR LA DETECTION DE L'EVENTUELLE TENDANCE D'INDIVIDUS IMMUNOPOSITIFS VIS-A-VIS DU VIRUS DE L'IMMUNODEFICIENCE HUMAINE HIV A AVOIR LE SIDA (SYNDROME IMMUNODEFICITAIRE ACQUIS), CARACTERISE EN CE QU'IL COMPREND : UNE SOLUTION DE TRANSCRIPTASE INVERSE DE L'HIV; UNE MATRICE APPROPRIEE D'ARN AMORCE; UN TRIPHOSPHATE DE NUCLEOSIDE, POUR LA SYNTHESE DE L'ADN; UN TEMOIN DE SERUM POSITIF, RENFERMANT UNE QUANTITE CONNUE D'ANTICORPS INHIBITEUR DE LA TRANSCRIPTASE INVERSE DE L'HIV; ET UN TEMOIN NEGATIF DE SERUM NE CONTENANT PAS D'ANTICORPS DE L'HIV. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LA DETERMINATION DES RISQUES DE SIDA POUR UN INDIVIDU HUMAIN, IMMUNOPOSITIF VIS-A-VIS DE L'HIV, CARACTERISE EN CE QUE L'ON DETECTE QUANTITATIVEMENT, DANS UN FLUIDE CORPOREL DE L'INDIVIDU, NOTAMMENT DANS SON SANG, LA PRESENCE D'UN ANTICORPS INHIBITEUR DE LA TRANSCRIPTASE INVERSE DE L'HIV. ELLE CONCERNE ENFIN UNE COMPOSITION THERAPEUTIQUE CONTRE LE SIDA, CARACTERISEE EN CE QUE SA MATIERE ACTIVE EST CONSTITUEE PAR DES ANTICORPS INHIBITEURS DE LA TRANSCRIPTASE INVERSE DE L'HIV. THE INVENTION CONCERNS A SET OR KIT OF REAGENTS FOR DETECTION OF THE POSSIBLE TREND OF IMMUNOPOSITIVE INDIVIDUALS TOWARDS THE HUMAN IMMUNODEFICIENCY VIRUS HIV TO HAVE AIDS (ACQUIRED IMMUNODEFICIARY SYNDROME), CHARACTERIZED IN THIS IT INCLUDES: A SOLUTION FOR REVERSE TRANSCRIPTASE OF HIV; AN APPROPRIATE PRIMERED RNA MATRIX; A NUCLEOSIDE TRIPHOSPHATE, FOR DNA SYNTHESIS; A POSITIVE SERUM INDICATOR, CONTAINING A KNOWN QUANTITY OF ANTIBODIES INHIBITOR OF HIV REVERSE TRANSCRIPTASE; AND A NEGATIVE SERUM INDICATOR NOT CONTAINING ANTIBODIES OF HIV. IT ALSO CONCERNS A PROCESS FOR DETERMINING THE RISKS OF AIDS FOR A HUMAN INDIVIDUAL, IMMUNOPOSITIVE TOWARDS HIV, CHARACTERIZED IN THAT IT IS DETECTED QUANTITATIVELY, IN A BODY FLUID OF THE INDIVIDUAL, ESPECIALLY IN HIS BLOOD, THE PRESENCE OF AN ANTIBODY INHIBITOR ...

Tractor hood

TRACTOR HOOD ABSTRACT OF THE DISCLOSURE In a tractor having a hood and a frame with a latch to establish a closed position of the hood on the frame, the present invention includes a frame track and a hood track secured to the frame and hood respectively, a pair of hood guides secured to the hood and movable in the frame track, a pair of frame guides secured to the frame and movable in the hood track and a mechanism for automatically rigidly connecting the hood to the frame in the closed position.

AIDS TREATMENT SET

L'ensemble selon l'invention pour le traitement d'une affection par le virus de l'immunodéficience humaine (HIV) est caractérisé par le fait qu'il comporte une formulation pharmaceutiquement acceptable d'un anticorps inhibant la transcriptase inverse et qui est obtenue à partir de la gamma globuline d'un patient connu pour produire des titres élevés de cet anticorps, soit sous la forme d'un anticorps monoclonal humain qui inhibe la transcriptase inverse de l'HIV. L'anticorps est destiné à être injecté, par voie intraveineuse ou musculaire, à un patient immunopositif à l'égard de l'HIV. The assembly according to the invention for the treatment of a condition with the human immunodeficiency virus (HIV) is characterized in that it comprises a pharmaceutically acceptable formulation of an antibody inhibiting reverse transcriptase and which is obtained from the gamma globulin of a patient known to produce high titers of this antibody, either in the form of a human monoclonal antibody which inhibits reverse transcriptase of HIV. The antibody is intended to be injected, intravenously or into the muscle, into a patient who is HIV positive.

Ve-ptp as regulator of ve-cadherin mediated processes or disorders

Implantable restriction device with protective member

An implantable restriction device ( 210 ) includes a belt and a balloon ( 220 ) secured to the belt for engagement with tissue when the implantable restriction device is positioned about an organ. A protective member ( 242 ) is associated with the balloon for positioning between the balloon and a tissue surface defining a band tissue interface.

AZEPINO [4, 5-B] INDOLES, A PHARMACEUTICAL COMPOSITION AND KITS THAT UNDERSTAND AND THEIR USE IN THE MODULATION OF A HISTAMINE RECEIVER.

Compuesto de azepino[4,5-b]indoles que se pueden usar para modular un receptor de histamina en un individuo. Se describen compuestos, incluyendo 1,2,3,4,5,6-tetrahidroazepino[4,5-b]indoles. También se provee composiciones farmacéuticas y kit que comprenden estos compuestos. Reivindicacion 1: Un compuesto de la formula (1) en donde R1 es H, hidroxilo, nitro, ciano, halo, alquilo C1-8 sustituido o no sustituido alquenilo C2-8 sustituido o no sustituido, alquinilo C2-8 sustituido o no sustituido, perhaloalquilo, acilo, aciloxi, carbonilalcoxi, heterociclilo sustituido o no sustituido, arilo sustituido no sustituido, heteroarilo sustituido o no sustituido, aralquilo sustituido o no sustituido, perhaloalcoxi C1-8, alcoxi, ariloxi, carboxilo, tiol, tioalquilo. amino sustituido o no sustituido, acilamino, aminoacilo, aminocarbonilamino, aminocarboniloxi, aminosulfonilo, sulfonilamino, sulfonilo, alquilsulfonilamino o carbonilalquilenalcoxi; cada R2a, R2b, R3a y R3b es, de modo independiente, H, hidroxilo, nitro, ciano, halo, alquilo C1-8 sustituido o no sustituido, alquenilo C2-8 sustituido o no sustituido, alquinilo C2-8 sustituido o no sustituido, perhaloalquilo, acilo, aciloxi, carbonilalcoxi, heterociclilo sustituido o no sustituido, arilo sustituido o no sustituido, heteroarilo sustituido o no sustituido, aralquilo sustituido o no sustituido, perhaloalcoxi C1-8, alcoxi, ariloxi, carboxiIo, tiol, tioalquilo, amino sustituido o no sustituido, acilamino, aminoacilo, aminocarbonilamino, aminocarboniloxi, aminosulfonilo, sulfonilamino, sulfonilo, alquilsulfonilamino o carbonilalquilenalcoxi o se toma junto con el carbono al que está unido y un R2 o R3 geminal para formar un resto de carbonilo; cada R10a, R10b, R11a y R11b es, de modo independiente, H, hidroxilo, nitro, ciano, halo, alquilo C1-8 sustituido o no sustituido, alquenilo C2-8 sustituido o no sustituido, alquinilo C2-8 sustituido o no sustituido, perhaloalquilo, acilo, aciloxi, carbonilalcoxi, heterociclilo ...

Tissue-specific self-inactivating gene therapy vector

The present invention provides a strategy that allows for selective switching off of both transgene and viral gene expression in tissues where such expression is undesirable. The present invention employs a vector containing a tissue specific promoter that drives expression of Cre recombinase gene in tissue where transgene expression is undesirable. As a result of Cre recombinase expression, the same or another vector that expresses the transgene in that tissue will be cut by the action of the Cre recombinase into several pieces due to LoxP sites that are strategically placed within the vector backbone. Consequently, unwanted transgene as well as viral gene expression are prevented.

Method, apparatus and user interface for determining an arterial input function used for calculating hemodynamic parameters

A graphical user interface and method allows a user to interactively select an arterial input function. An anatomical image and time-course data corresponding to a selected region of interest are displayed simultaneously. The time-course data is displayed as an array of graphs, annotated with best-fit curves and parameters derived from fitting the time-course data. The region displayed in the graphs may be updated by panning and zooming with a mouse in the image. Time-course data corresponding to a graph is selected for use in deriving an arterial input function. The arterial input function is used to calculate maps of hemodynamic parameters.

Silicon-containing polyols

Disclosed are essentially zinc-free, organic coating compositions based on silicon-containing polyols comprising reaction products of hydrophobic polyols, organosilicon-containing materials, and higher monohydric alcohols, R-OH. The organosilicon-containing material comprises an organosilicon-containing substance free of certain functional groups attached directly to carbon and essentially free of alkali metal ions. The organosilicon-containing substance has atoms bonded directly to Si all of which are selected from O, N, and/or Cl. The organosilicon-containing substance also has moieties directly bonded to Si which are displaceable by reaction with water and/or alcohol. The reaction product is not capable of being gelled when subjected to a specific gel test, has a content of hydroxyl groups from the hydrophobic polyol ranging from 0.4 to 10 milliequivalents per gram of reaction product, has a content of groups, --OR, from the higher monofunctional alcohol ranging from 0.1 to 7 milliequivalents per gram of reaction product, and a content of the moieties directly bonded to Si which are displaceable of less than 1 milliequivalent per gram of reaction product. The organic coating composition also contains a curing agent for for the silicon-containing polyol selected from the group consisting of an aminoplast, a phenoplast, an isocyanate, a blocked isocyanate, a semi-blocked isocyanate, a lower-alkoxy-containing silane, and a hydrolyzed lower- alkoxy-containing silane. The coating composition is essentially free of elemental zinc and cures to an essentially organic coating.

Single use air mattress

Composition and methods for creating syngeneic recombinant virus-producing cells

Replication-defective viruses and means for intracellular replication thereof are described which are useful for gene therapy. Human cells can be changed into recombinant replication-defective virus particle-producing cells by the simultaneous delivery to those cells of two different nucleic acids: the first being a replication-defective viral genome, the second being a nucleic acid that complements the viral sequences deleted from the first nucleic acid so as to result in the production of new infective virus. The first nucleic acid can be delivered by the replication-defective virus itself or, as a nucleic acid that is not part of the virus. In a preferred embodiment, the replication-defective virus includes elements to maintain the two nucleic acids in combination during transduction. Examples of preferred viral sources are adenoviruses, herpesvirus, retroviruses, and adeno-associated viruses. Nucleic acids useful for gene therapy include those that code for proteins used to identify cells infected with the recombinant virus, those that encode for proteins that function to kill cells containing the viral genome, or that encode for therapeutic proteins that will serve to treat a pathophysiologic condition within the body.

Nucleic acid aptamers conjugated to high molecular weight steric groups

The invention provides compositions and methods for making and using sterically enhanced antagonist aptamer conjugates that include a nucleic acid sequence having a specific affinity for a target molecule and a soluble, high molecular weight steric group that augments or facilitates the inhibition of binding to, or interaction with, the target molecule binding partner by the target molecule when bound to the aptamer conjugate. The present invention also provides methods and formulations for ocular delivery of a biologically active molecule by attaching a charged moiety to the biologically active molecule and delivering the biologically active molecule by iontophoresis. Iontophoresis of a biologically active molecule that is conjugated to a high molecular weight neutral moiety, in enhanced by substituting the high molecular weight neutral moiety with a charged molecule of comparable size.

Delivery of therapeutic biologicals from implantable tissue matrices

Normal cells, such as fibroblasts or other tissue or organ cell types, are genetically engineered to express biologically active, therapeutic agents, such as proteins that are normally produced in small amounts, for example, MIS, or other members of the TGF-beta family Herceptin™, interferons, and anti-angiogenic factors. These cells are seeded into a matrix for implantation into the patient to be treated. Cells may also be engineered to include a lethal gene, so that implanted cells can be destroyed once treatment is completed. Cells can be implanted in a variety of different matrices. In a preferred embodiment, these matrices are implantable and biodegradable over a period of time equal to or less than the expected period of treatment, when cells engraft to form a functional tissue producing the desired biologically active agent. Implantation may be ectopic or in some cases orthotopic. Representative cell types include tissue specific cells, progenitor cells, and stem cells. Matrices can be formed of synthetic or natural materials, by chemical coupling at the time of implantation, using standard techniques for formation of fibrous matrices from polymeric fibers, and using micromachining or microfabrication techniques. These devices and strategies are used as delivery systems via standard or minimally invasive implantation techniques for any number of parenterally deliverable recombinant proteins, particularly those that are difficult to produce in large amounts and/or active forms using conventional methods of purification, for the treatment of a variety of conditions.

Area divarication adhesive means

Spring coiling machine