NAVAL PLATFORM INCLUDING MEANS NET-SHAPED ANTI-TORPEDO

Cette plateforme navale (1) du type comportant des moyens de lancement de moyens en forme de filet anti-torpille de protection de la plateforme contre une arme sous-marine (4), est caractérisée en ce qu'elle comporte sur au moins l'un de ses bordés, à l'arrière de celle-ci, au moins un conteneur de réception des moyens (3) en forme de filet largables à l'arrière de la plateforme.

SAFETY DEVICE ANTI-CHUTE

PACKING SEALS FOR DRYING, IN PARTICULAR FREEZE-DRYING, AND PROCEEDED OF DRYING, IN PARTICULAR OF FREEZE-DRYING, USING SUCH A PACKING

PROCESS OF TOTAL TREATMENT OF NATURAL GAS ON A SITE OF STORAGE

TOUCH INTERFACE HAS SUPPORT SHELL, SHELL TOUCH AND MECHANICAL STRAIN SENSORS

PROCESS AND NONINVASIVE DEVICE OF FOCUSING Of ACOUSTIC WAVES

FASTENING OF SHEETS FOR ROOFS

MECHANICAL VACUUM CLEANER OF SMOKE RETRACTABLE BY SIDE RELEASE

HINGED BASE PLATE IMMERGEE AND PLATFORM COMPRISING IT

PASSIVE DEVICE Of INCREASE IN the EFFECTIVENESS OF TRANSMISSION OF SYSTEMESRADIOFREQUENCE

SYSTEM Of ANCHORING FOR SURGES ACETABULAIRE

CONTROL METHOD OF A VEHICLE POWER PLANT DURING A TRAVERSAL GAME ENGINE

RECEPTION ANTENNA MORCELEE

PROCESS FOR THE PURIFICATION OF A WET GAS CONTAINING VOC BY ADSORPTION USING A REGENERATION PHASE BY MICROWAVE HEATING

REPELLENT AND/OR INSECTICIDE METHOD

REMOVABLE SUPPORT FOR MATERIAL OF MEASUREMENT.

DEVICE TO RECEIVE the PROJECTION Of IMAGE ON a SUPPORT WHICH SWIVELS has 360°

STRUCTURE OF TRANSPORT, INSTALLATION AND DISMANTLING OF the ELEMENTS Of UNEPLATE-FORME PETROLIERE FIXED AND PROCEEDED OF IMPLEMENTATION Of SUCH a STRUCTURE.

COMFORT ELECTRONIC PRESENTING A MOBILE SCREEN

PROCESS AND DEVICE OF TRANSFORMATION Of THERMOPLASTIC COMPOSITE a MATERIAL FABRIC SHEET

ELECTRONIC DEVICE OF CONVERSION OF ELECTRICAL ENERGY

CONTROL METHOD OF A VEHICLE POWER PLANT DURING A TRAVERSAL GAME ENGINE

BOOKSTAND

PROCESS OF PURIFICATION Of a NATURAL GAS BY ADSORPTION OF the MERCAPTANS.

DEVICE OF TRANSFER Of a FLUID ON a SHIP, SHIP, TOGETHER WITH TRANSFER AND PROCESS ASSOCIATES

FOOD CONTINUES LOW TENSION FOR ELECTRONIC DEVICES OF COMMUNICATION

La présente invention concerne un système (100) d'alimentation en basse tension continue d'au moins un dispositif (3 ; 6) électronique de communication dans un système de communication à courant porteur en ligne comportant en outre un coupleur à courant porteur en ligne comprenant un condensateur (10) de couplage relié électriquement à une ligne moyenne tension (8) d'un réseau électrique de distribution. Selon l'invention, le système (100) comprend des moyens (15) de génération d'une première valeur de basse tension continue à partir d'une conversion courant-tension du courant de fuite relatif audit condensateur (10) de couplage, ladite première valeur de basse tension continue étant apte à servir d'alimentation à au moins un composant (13) électronique actif dudit au moins un dispositif (3 ; 6) électronique de communication.

DYNAMIC METHOD OF PARTIAL OR TOTAL REMOVAL OF ORGANIC WASTE COMPOUNDS IN BEVERAGES, PARTICULARLY IN WINE

La présente invention concerne un procédé d'élimination de composés polyhalogénés toxiques ou indésirables dans des boissons, ledit procédé comportant une étape de mise en contact de la boisson avec un adsorbant contenant un matériau polymérique. Selon l'invention, l'étape de mise en contact consiste à faire circuler la boisson dans une colonne contenant ledit adsorbant.

NAVAL PLATFORM INCLUDING MEANS NET-SHAPED ANTI-TORPEDO

FOLDING HOOD FOR MOTOR VEHICLE

DETECTOR OF COMPOSE HAS RISK

MEDICAL APPARATUS FOR THE EXTRACORPORAL TREATMENT OF BLOOD OR PLASMA AND MANUFACTORING PROCESSES OF THIS APPARATUS

MACHINING SYSTEM FOR A MOTOR VEHICLE.

Un marchepied (10) repliable comprend : - un bâti (1) fixe par rapport au cadre (27) de porte, - un dispositif support (2) supportant une plaque d'appui (20), monté à pivotement par rapport au bâti fixe, de manière à pouvoir être incliné puis relevé autour d'un axe de rotation (4) du marchepied, la plaque d'appui (20) étant montée pour coulisser en translation par rapport au dispositif support (2), -un système de liaison (22) reliant le bâti fixe (1) et le dispositif support (2), configuré pour faire successivement avancer puis reculer la plaque (20) par rapport au dispositif support (2), conjointement à l'inclinaison de la plaque. La plaque d'appui (20) est montée pour coulisser en translation par rapport au dispositif support.

Dry natural gas liquefying method for transporting liquefied gas via seaway, involves bringing cooled gas phase into contact with adsorbent solid to obtain purified gas phase, and cooling and liquefying purified gas phase by heat exchange

L'invention concerne un procédé de liquéfaction d'un gaz naturel dans lequel, (a) on met en contact le gaz naturel avec une solution aqueuse enrichie en solvant pour obtenir une phase gazeuse enrichie en solvant et une phase aqueuse appauvrie en solvant, (b) on refroidit et on condense partiellement par échange de chaleur ladite phase gazeuse enrichie en solvant pour produire une phase gazeuse refroidie et des condensats, (c) on sépare la phase gazeuse refroidie desdits condensats, (d) on met en contact ladite phase gazeuse refroidie avec au moins un solide adsorbant pour obtenir une phase gazeuse purifiée, ledit solide adsorbant au moins l'un des composés suivants : l'eau, ledit solvant et des hydrocarbures lourds, (e) on refroidit et on liquéfie par échange de chaleur ladite phase gazeuse purifiée obtenue à l'étape (d). L'invention s'applique au traitement du gaz naturel et au traitement des gaz naturel dits secs.

INTEGRATED CIRCUIT CARRIED OUT BY ONESELF INCLUDING/UNDERSTANDING ADJACENT CELLS OF VARIOUS TYPES

METHOD FOR CONTROLLING THE OPERATION OF AN ELECTRONIC COMPONENT, AN ELECTRONIC DEVICE AND CORRESPONDING ONBOARD ELECTRONIC CALCULATOR

DEVICE AND PROCESS OF DETECTION AND PREVENTION Of INTRUSION IN a Data-processing network

PROCESS AND TRANSPORTABLE DEVICE Of EXPLORATION AND UNDERWATER INTERVENTION INTEND FOR RECOVERY VALUABLE ARTICLES ABYSSES BY Great depth.

DISPENSING DEVICE AND SET OF SUCH DELIVERY DEVICES

PREDICTIVE METHOD FOR CONTROLLING THE OPERATION OF ELECTRONIC EQUIPMENT, ELECTRONIC EQUIPMENT AND CONTROL DEVICE

A METHOD OF DEFINING A CURVE OF LOADS OPTIMIZED FOR CRANE, METHOD AND TESTING DEVICE FOR TESTING THE DISCHARGE CUTTING PROCESSES FROM THE CURVE CHARGE OPTIMIZED

SOFT SOLID COSMETIC COMPOSITION COMPRISING ANIONIC SURFACTANTS AND NON-POLYMERIC CONDITIONING AGENTS, AND COSMETIC TREATMENT METHOD

STRUCTURE OF CASE AND VEHICLE INCLUDING/UNDERSTANDING SUCH A STRUCTURE OF CASE

METHODS OF REMOVING AND RECOVERING TANTALUM PRESENT IN AN ACIDIC AQUEOUS PHASE BY MEANS OF AN IONIC LIQUID, AND USE OF SUCH IONIC LIQUID FOR EXTRACTING THE TANTALUM OF AN ACIDIC AQUEOUS PHASE

RAILWAY BRAKING SYSTEM FOR A POWER SAW

EQUIPMENT TO FILL the CIRCUMFERENCE Of an OPENING SPARES IN a WALL TO ALLOW the PASSAGE Of a CONDUIT

NONVOLATILE MEMORY PROGRAMMABLE RESISTANCE

OBSERVATION INSTRUMENT BEING INCORPORATED ON A SPACECRAFT AND SPACECRAFT EQUIPPED WITH SUCH AN INSTRUMENT

METHOD OF EQUALIZATION FOR A COMMUNICATION CHANNEL SPARSITY AND DEVICE THEREFOR

Arrangement for fixing anemometric probe on opening of structural panel of aircraft, has support element comprising set of holes, flange comprising dimensions and form to surround tap opening, where flange is attached to panel

L'invention concerne un agencement pour la fixation d'un dispositif de mesure (10) sur une ouverture d'un panneau structural (2) d'aéronef présentant une surface extérieure. Selon l'invention, cet agencement comprend: - une paroi d'obturation (1) destinée à être reçue dans ladite ouverture en ayant sa surface externe affleurant avec ladite surface extérieure, cette paroi d'obturation (1) comportant au moins un premier orifice (4) de prise de pression, - ladite paroi d'obturation (1) comportant également des seconds orifices destinés à recevoir des premiers organes de fixation (5) pour l'assemblage de ladite paroi (1) sur un élément de support (6), lesdits organes de fixation (5) ayant une extrémité destinée à être affleurant avec la surface extérieure dudit panneau structural (2), - ledit élément de support (6) comportant des trous pour le passage de la tige de seconds organes de fixation (13) en vue de son assemblage avec une collerette structurale (14), - ladite collerette structurale ...

SYSTEM FOR VISUALIZING DATA OF AN ELECTRIC METER.

L'invention porte sur un système 1,11 pour rendre compréhensibles et accessibles des données d'un compteur électrique 2 à un abonné possédant une box Internet 3, comprenant une interface 1, branchée à une sortie TIC 12 du compteur et un logiciel 11, implémenté dans la box, l'interface comprenant des moyens pour communiquer avec la box. Un tel système est particulièrement avantageux, puisqu'il permet d'informer et d'impliquer un abonné sur sa facture (abonnement et consommation) et sur les possibilités de la maîtriser et de la réduire, sans que cet abonné ait à installer un boîtier ou un dongle, du côté de sa box Internet, ou installer une box additionnelle.

ANTENNA HIGH FREQUENCY

L'invention concerne une antenne inductive formée d'au moins deux paires de tronçons (32, 34) géométriquement bout à bout et comportant chacun un premier (322, 342) et un second (324, 344) éléments conducteurs parallèles et isolés l'un de l'autre, chaque paire comportant à chaque extrémité une unique borne de raccordement électrique de son premier élément conducteur à celui de la paire voisine, dans laquelle lesdites paires sont : d'un premier type (3) dans lequel les éléments conducteurs sont interrompus approximativement en leur milieu pour définir les deux tronçons, le premier, respectivement second, élément conducteur d'un tronçon étant connecté au second, respectivement premier, élément conducteur de l'autre tronçon de la paire ; ou d'un second type dans lequel le premier élément conducteur est interrompu approximativement en son milieu pour définir les deux tronçons, le second élément conducteur n'étant pas interrompu.

Mechanical device i.e. squirrel cage shaped heliocentripeted wheel turbine, for e.g. pumping drinking water, has divergent cylindro-rectangular drains bent backward to support control surfaces to create wind vane effect

Dispositif de captage mécanique de l'énergie cinétique du vent moyen à fort accéléré par canalisations à tube de venturi munies d'une turbine panémone à double roues héliocentripètes carénées par des volutes, tournant sur un axe commun horizontal perpendiculaire au sens du vent qui l'oriente par des gouvernes à effet girouette. Une canalisation convergente rectangulaire capte selon la section, face au vent un volume d'air défini pour l'accélérer et le distribuer dans les volutes des roues-turbine afin qu'il cède son énergie cinétique à vitesse circonférencielle et circonvolutive à travers toutes les aubes pour échapper latéralement dans les coudes cylindriques de détente. Deux canalisations divergentes à sortie rectangulaires atténuent les turbulences et favorisent la dépression d'air au contact du vent ayant contourné la cellule du dispositif. Des gouvernes fixées sur l'arrière des canalisations divergentes assurent la prise au vent instantané sur un ou deux axes de liberté situés sur ...

BEARING GUIDE HEAD

Guide d'appui tête, agencé pour guider une tige d'appui tête de véhicule, le guide d'appui tête comprenant : - des moyens de guidage agencés pour guider la tige d'appui tête, - une interface de fixation, agencée pour être fixée sur une armature (50) de dossier de véhicule, caractérisé en ce que le guide comprend un portion de liaison (30) agencée entre les moyens de guidage et l'interface de fixation, pour déporter les moyens de guidage de l'interface de fixation.

METHOD FOR PRODUCING RED PHOSPHOR ACTIVE INORGANIC BY EU2+

L'invention concerne un procédé de fabrication d'un luminophore rouge inorganique activé par Eu2+ où le luminophore présente un spectre d'émission qui peut être résolu en une première courbe d'émission gaussienne et une seconde courbe d'émission gaussienne; où la première courbe d'émission gaussienne a un pic de première courbe d'émission gaussienne, P1; où le pic de première courbe d'émission gaussienne, P1, a une hauteur de pic 1, HP1, une longueur d'onde de pic du pic 1, PλP1, et une aire de pic 1, AP1; où la seconde courbe d'émission gaussienne a un pic de seconde courbe d'émission gaussienne, P2; où le pic de seconde courbe d'émission gaussienne, P2, a une hauteur de pic 2, HP2, une longueur d'onde de pic du pic 2, PλP2, une largeur à mi-hauteur de pic 2, FWHMP2, et une aire de pic 2, AP2; où PλP1 < PλP2; et où la largeur à mi-hauteur de pic 2, FWHMP2, est minimisée.

NEW ARCHITECTURE OF COMPENSATOR OF the HARMONIC AND POWER-FACTORS FOR Distribution network Of ENERGY

METHOD OF DEACTIVATING A FUNCTION FOR APPROVAL REMEDY FOR A DRIVE OF A VEHICLE

FORAGE LADDER FOR A MOTOR VEHICLE

MANUFACTORING PROCESS AND INSTALLATION OF FILLING Of a FUSE

METHOD FOR LIQUEFYING NATURAL GAS SEC.

METHOD OF MANAGING A SET OF COMMUNICATING OBJECTS ALLOWING THE PROPAGATION OF A SIGNAL, IN PARTICULAR A DESIRED WAKE-UP, BETWEEN SAID OBJECTS

METHOD OF PREPARATION OF LIPIDIC NANOPARTICULES

METHOD FOR THE PRODUCTION OF TOOLS FOR HOLDING CARTRIDGE AND SUCH THAT THE CAP ON THE BODY OF A VEHICLE DURING THE PAINTING

HARBOUR STRUCTURE AT SEA

METHOD FOR MANAGING A TORQUE MOTOR UPON A HARD DECELERATION INJECTION AND CORRESPONDING VEHICLE

IN-BOXES AND DEVICE FOR CREATING A SLOPE FOR A FLEXIBLE SEALED POUCH CONTAINED IN A RIGID CONTAINER OF A BAG-IN-BOX

NEW DERIVATIVES OF 5-THIOXYLOPYRANOSE

DEVICE HAS USE OENOLOGICAL MAKING IT POSSIBLE TO GIVE INDICATIONS ON LAQUALITE OF THE WINES AND THEIR APTITUDE FOR AGEING

PROCESS OF RECOVERY OF THE METALS CONTAINED IN ELECTRONIC WASTE

TOGETHER OF MEMBRANE MODULES Of ULTRAFILTRATION OR MICROFILTRATION, MODULATES MEMBRANE, CONSTRUCTION AND PROCEEDED OF MAINTENANCE CORRESPONDENTS

SUPPORTED BY CARBON NANOTUBES AND BY THE GRAPHENE SHEETS, AND METHOD FOR PREPARING SAME

La présente invention concerne un catalyseur de formule M1(NTC/Gr) supporté par des nanotubes de carbone et par du graphène. Elle concerne également le procédé de préparation de ce catalyseur, comprenant les étapes suivantes : a) préparation de particules M1/NTC d'un métal de transition M1 et supportées par des nanotubes de carbone NTC, par réduction thermique d'un sel d'un métal de transition M1 en présence de nanotubes de carbone ; b) préparation de particules M1/Gr d'un métal de transition M1 et supportées par du graphène Gr, par réduction thermique d'un sel d'un métal de transition M1 en présence de graphène ; c) mélange des particules M1/NTC issues de l'étape a) avec les particules M1/Gr issues de l'étape b) ; d) obtention d'un catalyseur supporté par des nanotubes de carbone et par du graphène de formule M1(NTC/Gr). L'invention concerne en outre l'utilisation du catalyseur de formule M1(NTC/Gr) dans une pile à combustible à membrane échangeuse de protons ou dans un électrolyseur à ...

LID FOR the CLOSING Of a POT OF PREPARATION OF YOGHOURT OR SOFT WHITE CHEESE.

[...] DUNNAGE FOR CHAIR

METHOD FOR GRAFTING A CARBON SUBSTRATE, AND THE USE OF THE SUBSTRATE IN A FUEL CELL

La présente invention concerne un procédé de greffage d'un substrat en carbone comprenant les étapes suivantes : a)préparation d'une solution contenant au moins un sel de diazonium de formule (I) dans laquelle : ○ au moins deux des groupements R1, R2, R3, R4 et R5 sont différents d'un atome d'hydrogène ; ○ au moins deux des groupements R1, R2, R3, R4 et R5 sont des groupements hydrophobes ou des groupements hydrophiles ou un groupement hydrophobe et un groupement hydrophile ; b) mise en contact d'un substrat en carbone avec cette solution de sel de diazonium ; c) greffage du substrat en carbone par réduction du sel de diazonium ; d) obtention d'un substrat en carbone greffé avec le groupement aromatique de formule (C6R1R2R3R4R5).

PROCEEDED OF PREPARATION Of a STRUCTURE CHEMICAL PRESENTING a PARTITION OF PHASES, READY TO GENERATE a SPECIFIC SPECTRUM OF FLUORESCENCE AND ITS APPLICATIONS

Résumé : L'invention a pour objet un procédé de préparation d'une structure chimique assemblée ou un mélange de telles structures, cette structure présentant une partition de phases, notamment de nature hydrophobe et hydrophile, comme une particule composite/ synthétique ou un liposome, et étant apte à générer un spectre de fluorescence original. L'invention a également pour objet lesdites structures assemblées et leur mélange ainsi que les compositions ou kit les comprenant. L'invention concerne aussi l'utilisation de ces structures assemblées et leur mélange, notamment pour l'imagerie médicale in vivo ou pour diagnostic in vitro de pathologie, mais également pour le marquage d'un échantillon, d'un objet ou d'une composition liquide ou pour leur authentification. L'invention comprend également les objets ou liquides marqués par les structures assemblées, leur mélange ou par les compositions selon l'invention.

BUFFER THREADED DOUBLE AND SINGLE GRADUATED LENGTH AND DIAMETER THREADED METER

L'invention concerne un dispositif permettant de réaliser le contrôle avec précision et simplement de la longueur filetée d'un trou taraudé ainsi que son diamètre. Il est constitué d'un manche moleté ou hexagonal (1) d'une partie filetée n'entre pas (2) et d'un embout filetée (3) se trouvant au bout d'un manche rallongé gradué au laser (4) le zéro est situé sur le sommet du premier filet (5). L'utilisateur contrôle la conformité de la longueur filetée et le diamètre du trou taraudé en vissant le dispositif côté entre (3) complétement dans le trou taraudé et lit directement la valeur mesurée sur le manche rallongé gradué au laser (4). Le dispositif selon l'invention est particulièrement destiné au contrôle des pièces dans les services qualité ainsi que pour réaliser le contrôle des pièces en cours de fabrication chez les usineurs.

Pharmaceutical and/or cosmetic and/or veterinary products distributing device, has tank formed of vibrating rear plate with inclined zone so that pharmaceutical and/or cosmetic and/or veterinary products move forward toward supplying units

Dispositif de distribution de produits pharmaceutiques et/ou cosmétiques et/ou vétérinaire comportant un réservoir et des moyens d'acheminement, caractérisé en ce qu'il est formé d'une plaque arrière vibrante avec une zone montante dans le sens d'acheminement des produits, formant le fond du réservoir et d'une plaque avant permettant de guider lesdits produits où est ménagé une pluralité de canaux d'acheminement, chaque canal étant apte à recevoir à l'intérieur une pluralité de produits empilés. Plus précisément, lesdits canaux prennent naissance dans la plaque arrière et sont ouverts sur le dessus jusqu'au sommet de la zone montante. A la fin de la zone montante, les canaux se prolongent avec un couvercle jusqu'au bord inférieur de la plaque avant.

METHOD OF MANUFACTURING SEMICONDUCTOR ON INSULATOR

La présente invention concerne un procédé qui est adapté pour produire une structure de semi-conducteur sur isolant, telle qu'une structure de Ge(Si) sur isolant ou une structure de Ge sur isolant. Selon le procédé, une structure multicouche comprenant des paires de couches alternées, comprenant une couche de silicium et une couche de germanium facultativement avec du silicium est déposée sur un substrat en silicium comprenant une couche tampon de germanium. La structure multicouche est complétée par une couche de passivation de silicium. Un plan de clivage est formé dans la structure multicouche, et la structure multicouche est liée à un substrat de manipulation comprenant une couche diélectrique. La structure multicouche est clivée le long du plan de clivage de manière à préparer une structure de semi-conducteur sur isolant comprenant un substrat de manipulation de semi-conducteur , une couche diélectrique, une couche de passivation de silicium, et au moins une partie des paires de couches ...

LIMP OF ARRANGEMENT Of INSTRUMENTS Of ENDODONTICS AND PROCESS OF IMPLEMENTATION

L'invention a pour objet une boîte (1) de rangement d'instruments d'endodontie, caractérisée en ce qu'elle comprend : - au moins un ensemble plan de logements (4) d'instruments, - au moins une ouverture (6) destinée au nettoyage des instruments et à l'évacuation de déchets, et - une pluralité d'éléments frangibles (7) destinés au comptage du nombre d'utilisation des instruments.

Surveillance beacon for detection of intrusion in e.g. site, has support structures drawn up to form protective cage, where support structures are folded back around base so as to give off mast and head in usage position

L'invention a pour objet une balise de surveillance qui comporte une base d'assise au sol (4) sur laquelle est rapporté un mât à déploiement télescopique (6) et une tête de détection et d'identification d'intrusion (8) montée à une extrémité de ce mât. La balise comporte en outre des structures support de panneaux solaires (10) qui sont montées pivotantes sur la base d'assise au sol. La balise est adaptée à prendre une position de transport, dans laquelle les structures support de panneaux sont dressées pour former une cage protectrice de la balise, ou une position d'utilisation, dans laquelle les structures support de panneaux sont rabattues à plat autour de la base de manière à dégager le mât et la tête de détection associée.

Purification of wet gaseous effluent containing volatile organic compound by performing adsorption step by passing gaseous effluent in adsorption column/adsorber, and performing first regeneration phase by heating first adsorbent bed

La présente invention décrit un procédé de purification d'un gaz humide chargé en composés organiques volatils (COV) comprenant une phase de régénération des lits d'adsorption faisant appel à une chauffage par micro-ondes.

Rear hatch for motor vehicle, has interior lateral branch widening visible width via rear window and slantedly directed towards exterior to rear window at longitudinal median plane of vehicle

Un hayon pour un véhicule automobile comporte un cadre, qui est formé par des montants latéraux (10) et avec lequel est assemblée une lunette arrière, et une largeur de visibilité à travers la lunette arrière est limitée entre les montants latéraux (10), qui sont constitués chacun par un profilé en forme de U . Les bords latéraux de la lunette arrière (20) sont reliés à des branches d'appui (18, 19) en saillie sur les montants en forme de U. Il est prévu sur le profilé formant le montant une branche intérieure (15), qui agrandit la largeur de visibilité à travers la lunette arrière (20) et qui s'étend en oblique vers l'extérieur par rapport au côté extérieur du véhicule et est dirigée avec son extrémité vers la lunette arrière.

THE RUNNING GEAR OF A MOTOR VEHICLE.

La présente invention concerne un train de roulement (1) pour un véhicule (2) automobile destiné à rouler suivant une direction longitudinale (X) sur une chaussée (3), le train de roulement (1) comprenant au moins une pièce (4) à protéger d'un obstacle extérieur (5), le train de roulement (1) étant caractérisé en ce qu'il comprend un déflecteur (6) pour protéger ladite pièce (4) de toute collision avec l'obstacle extérieur (5), ledit déflecteur (6) présentant : une base (7) formant interface de solidarisation pour sa solidarisation audit train de roulement (1) ; et au moins une surface de protection (8) formant bouclier par rapport à la pièce (4) à protéger, ladite surface de protection (8) étant orientée vers une direction longitudinale (X) et vers la chaussée (3).

METHOD OF PREPARING A SUPPORTED CATALYST BY CARBONACEOUS MATERIAL MODIFIED WITH POLYBENZIMIDAZOLE

La présente invention concerne un procédé de préparation d'un catalyseur supporté comprenant au moins les étapes successives suivantes : a) traitement thermique d'un matériau carboné (C), à une température comprise entre 1400°C et 2300°C, le matériau carboné (C) étant choisi dans le groupe comprenant les nanotubes de carbone, le graphène, et les noirs de carbone, b) obtention d'un matériau carboné traité thermiquement (Ct), c) modification du matériau carboné Ct par mise en contact avec au moins un polybenzimidazole (PBI), d) obtention d'un matériau carboné modifié (Ct-PBI), e) dépôt de particules métalliques (M) sur le matériau carboné modifié (Ct-PBI), f) obtention d'un catalyseur supporté (M/Ct-PBI).

ENERGY STORAGE, INJECTED INTO AN ELECTRICAL NETWORK

L'installation (10) de stockage d'énergie comporte un dispositif (12) de fourniture d'énergie mécanique, un réservoir (32) de stockage d'un fluide sous pression, une pompe (16), actionnable par le dispositif de fourniture d'énergie mécanique (12), un générateur d'énergie (36), propre à convertir l'énergie du fluide sous pression en énergie électrique, ledit générateur d'énergie (36) étant propre à être connecté à un réseau électrique l'alimenter en énergie électrique, et un circuit (28) de circulation de fluide, reliant d'une part la pompe (16) au réservoir de stockage (32), de manière à y injecter du fluide lorsqu'elle est actionnée, et reliant d'autre part le réservoir de stockage (32) au générateur d'énergie (36). Le circuit de circulation (28) comprend au moins une vanne agencée entre le réservoir de stockage (32) et le générateur d'énergie (36), ladite vanne étant manœuvrable entre une position ouverte autorisant l'alimentation du générateur d'énergie électrique (36) en fluide sous ...

METHOD OF ESTIMATING [...] TRAVELED BY A USER

Procédé d'estimation du dénivelé franchi par un utilisateur, ledit procédé utilisant un capteur de pression et un capteur de température, le capteur de pression étant adapté pour être maintenu sensiblement solidaire de l'utilisateur, le procédé comprenant au moins : a) une opération d'échantillonnage périodique des valeurs brutes de pression, relevant la pression brute courante à une première fréquence d'échantillonnage (F1), les valeurs brutes étant stockées sous forme de pression ou d'altitude correspondante dans un premier buffer (B1), b)- une opération de filtrage basée sur les valeurs brutes stockées dans le premier buffer (B1) pour déterminer des valeurs filtrées, c) - un calcul de variance, opéré sur au moins une partie des valeurs filtrées, en vue de déterminer une condition de prise en compte des dénivelés correspondant aux différences de pression ou altitude constatées.

Repositionable self-adhesive closed-cell solid-foam insulation material

La présente invention concerne un matériau multicouche autocollant, léger pour construction qui produit une isolation thermique ou acoustique comprenant une couche de revêtement, une couche de liaison de revêtement comprenant un film adhésif, au moins une couche de mousse solide et une couche de face adhésive. La couche de masse solide (2) comprend une mousse solide de gaz piégé dans des cellules thermoplastiques (3) et la couche de face adhésive (5) comporte une face adhésive autocollante. Une couche de revêtement (1) présente une réflexion thermique ou d'autres propriétés et la couche de face adhésive (5) est protégée par un film antiadhésif (6) avant installation. Le matériau est installé par découpe aux dimensions requises avant de retirer le film antiadhésif (6) et collage du matériau au moyen d'une légère pression pour appliquer la couche de face adhésive (5) sur la région devant être isolée.

SUPPORT AND TOOL STORAGE METHOD FOR GRIPPING A SHEET

L'invention concerne un support (1) de dépose et de rangement d'outil (16) à longeron, telle une main de préhension de tôle. Le support (1) comprend une face supérieure de rangement (14) avec une direction principale longitudinale (15), et deux poutres longitudinales (1a, 1b) qui forment la face supérieure de rangement (14). Les poutres longitudinales (1a, 1b) reçoivent un longeron (18) d'outil (16) le long de cette direction longitudinale (15). Le support (1) comprend en outre un système d'indexage (6) pour détecter le dépôt ou la reprise de l'outil (1), et un capot de protection (8) pour recouvrir l'outil. L'invention propose également un procédé de rangement et de reprise d'outil. Le support offre donc une face de rangement standardisée s'adaptant à différentes géométries de mains de préhension de tôle sur les chaînes de fabrication de véhicules automobiles.

COMPOSE ANTIFONGIQUES, COMPOSITIONS CONTAINING THESE COMPOSE AND THEIR USES

L'invention fournit de nouveaux composés antifongiques de formule (I) telle que définie dans la présente description. L'invention fournit aussi des compositions pharmaceutiques antifongique pour l'utilisation en médecine humaine ou vétérinaire, qui comprennent un composé de formule (I). L'invention est aussi relative à un composé de formule (I) tel que défini dans la présente description, pour son utilisation en tant que médicament. L'invention a également trait à l'utilisation d'un composé de formule (I) pour la fabrication d'une composition pharmaceutique antifongique humaine ou vétérinaire.

DEVICE FOR ADJUSTING THE POSITION OF THE PAD SUPPORT SHOE IN A SKI BINDING SYSTEM

La présente invention se rapporte à un dispositif de réglage de la position verticale du patin d'appui (P) de chaussure dans un système de fixation de ski comprenant, notamment, une butée avant pourvue d'une embase (E) et d'un corps (C), ledit dispositif comprenant un élément (1) de support du patin (P) et une cale (2), caractérisé en ce que ledit élément de support (1) est mobile en pivotement et comporte au moins une rampe (11) coopérant par contact avec un poussoir (21) formant levier actionné par ladite cale (2) qui est susceptible de se déplacer en translation longitudinale sous l'action d'un organe de manœuvre (3).

COMPOSITION INCLUDING/UNDERSTANDING SURFACE-ACTIVE NONIONIC, an OXIDE CONDENSATION POLYMER Of PROPYLENE ETHYLENE AND OXIDE AND an ALCOHOL AND PROCESS OF CLEANING OF the HAIR

La présente invention a pour objet une composition comprenant - (i) au moins 20% en poids par rapport au poids total de la composition d'au moins un monoalcool en C2-C4, - (ii) au moins un polycondensat d'oxyde d'éthylène et d'oxyde de propylène. - (iii) au moins un agent tensioactif non ionique différent des polycondensats (ii). Elle a également pour objet l'utilisation de cette composition pour le nettoyage des cheveux, et un procédé nettoyage de ces derniers utilisant cette composition.

REMOVABLE ELECTRONIC SYSTEM TRIGGERING DEPLOYMENT OF INFLATABLE VEST SECURITY

La présente invention concerne un système de déclenchement (1) du déploiement d'un gilet gonflable de sécurité étant remarquable en ce qu'il comporte un carter (2) agencé pour être solidaire dudit gilet gonflable de sécurité et muni d'un premier évidement (21) apte à recevoir, de façon réversible, un boîtier (3) comprenant au moins une carte électronique, des moyens de connexion et un accumulateur d'énergie, ledit premier évidement (21) étant muni en partie supérieure d'un logement (22) au fond duquel sont disposés les moyens de connexion du carter (2) et dans lequel vient s'insérer au moins la partie supérieure (31) du boitier (3) pour permettre sa connexion de manière étanche avec ledit carter (2).

YEAST STRAINS CO-EXPRESSING EXOGENOUS GLUCOAMYLASES, THEIR PRODUCTION AND THEIR USE FOR PRODUCING BIOETHANOL

La présente demande a pour objet des souches de levure de Saccharomyces cerevisiae améliorées, caractérisée en ce qu'elles co-expriment un gène codant une glucoamylase d'origine fongique et un gène codant la glucoamylase de Saccharomyces cerevisiae var. diastaticus. La présente invention concerne également une méthode d'obtention de ces souches de levure, ladite méthode comprenant les étapes suivantes : a) modification génétique d'une levure de Saccharomyces cerevisiae de manière à la faire co-exprimer un gène codant une glucoamylase d'origine fongique et un gène codant la glucoamylase d'Saccharomyces cerevisiae var. diastaticus; b) mise en culture et fermentation de la souche obtenue à l'étape a) sur un milieu dextrine ; c) sélection des souches présentant une cinétique de fermentation au moins égale ou supérieure à la souche déposée le 9 Juillet 2015 en vertu du traité de Budapest à la CNCM sous le numéro I-4999 dans les mêmes conditions. Les souches de levure selon l'invention trouvent ...

FLOATING DUMBBELL CHANGEABLE FOR PRACTISING WATER ACTIVITIES

La présente invention concerne un haltère pour la pratique d'exercices aquatiques, caractérisé en ce qu'il est modifiable dans sa constitution pour être adapté particulièrement à l'état physique de son utilisateur et prendre des configurations différentes au cours des programmes d'exercices physiques et sportifs en milieu aquatique. Les « masse active » qui équipent les extrémités de l'« axe de préhension » sont de formes, dimensions et conception adaptées et compatibles pour nécessiter des efforts variés et divers lors de la pénétration dans l'eau. Elles sont verrouillées en position sur l'« axe de préhension » ou sur les « axes d'extrémité » dudit « axe de préhension » par divers moyens mécaniques et peuvent prendre plusieurs positions autour dudit axe. L'haltère de l'invention se compose principalement d'un «axe de préhension» (100) sur lequel est installé en force un « manchon d'axe » (300), aux extrémités duquel sont placées une pluralité de « masse active » (200) immobilisées en position ...

TELESCOPIC MAST ASSEMBLY AND METHOD OF MAKING SAME HAS AUTOMATIC UNFOLDING AND FOLDING COMPRISING SUCH A CLEAR FILMS

Ce mât télescopique comprend un premier tronçon de mât (10) et un deuxième tronçon de mât (20) coulissants. Les premier et deuxième tronçons de mât ont des sections polygonales à au moins huit faces. Les premier et deuxième tronçons de mât comprennent au moins deux organes d'appui primaires et au moins deux organes d'appui secondaires situés respectivement dans deux régions séparées par un plan de fibre neutre (P31). Les organes d'appui primaires et secondaires transmettent des efforts de torsion. Les formes polygonales des sections transversales des premier et deuxième tronçons de mât sont configurées pour que : les deux organes d'appui primaires transmettent deux forces primaires (F11) résultant de la flexion et concourant en un point d'intersection primaire (P11), les deux organes d'appui secondaires transmettent deux forces secondaires (F21) résultant de la flexion et concourant en un point d'intersection secondaire (P21) distant du point d'intersection primaire (P11).

TELESCOPIC MAST ASSEMBLY AND METHOD OF MAKING SAME HAS AUTOMATIC UNFOLDING AND FOLDING COMPRISING SUCH A CLEAR FILMS

ELECTRONIC CONTROL MODULE AND METHOD FOR TESTING THE FUNCTIONING AND SECURITY OF AT LEAST RADIANT TUBE BURNER

Module de contrôle d'au moins un brûleur à tube radiant, le brûleur comprenant une vanne d'alimentation en combustible, une vanne d'alimentation en comburant et un conduit évacuation des fumées de combustion, le module de contrôle comprenant : . un moyen de mesure de la qualité de la combustion installé dans le conduit d'évacuation des fumées de combustion dudit au moins un brûleur, . un organe de mesure de débit de combustible, un organe de mesure de débit de comburant, . un moyen de pilotage dudit au moins un brûleur, agissant sur les pourcentages d'ouverture des vannes d'alimentation en comburant et combustible dudit au moins brûleur pour adapter le rapport débit de comburant/débit de combustible en fonction de l'information délivrée par le moyen de contrôle de la qualité de la combustion.

PROCESS AND DEVICE OF RECOVERY OF the OIL Of a TANK LAY OUT ON MARINE UNFOND, IN PARTICULAR Of a WRECK

CORRECTOR, DEVICE AND PROCESS FOR the ORDERING OF the ELECTROMAGNETIC COUPLE Of an ASYNCHRONOUS MACHINE

CORRECTOR, DEVICE AND PROCESS FOR the ORDERING OF the ELECTROMAGNETIC COUPLE Of an ASYNCHRONOUS MACHINE

CORRECTOR, DEVICE AND PROCESS FOR the ORDERING OF the ELECTROMAGNETIC COUPLE Of an ASYNCHRONOUS MACHINE

OprF/I AGENTS AND USE THEREOF IN HOSPITALIZED AND OTHER PATIENTS

The present invention relates to a new use of a vaccine comprising a fusion protein that comprises the outer membrane protein I (OprI or OMPI) which is fused with its amino terminal end to the carboxy-terminal end of a carboxy-terminal portion of the outer membrane protein F (OprF or OMPF), as well as to a new use of a monoclonal or polyclonal antibody against this fusion protein or a pharmaceutical composition thereof. 1. A method of reducing mortality in a subject , comprising administering to said subject a therapeutically effective amount of an OprF/I agent , wherein said subject is selected from the group consisting of:i) a hospitalized patient or a subject who is at risk of being hospitalized;ii) an ICU patient or a subject who is at risk of being admitted to ICU;iii) a ventilated ICU patient or a subject who is at of risk being ventilated;iv) a burn victim patient; andv) a cystic fibrosis patient.2. The method of claim 1 , comprising co-administration of a therapeutically effective amount of an OprF/I agent and a second drug substance claim 1 , wherein said second drug substance is an antimicrobial or antifungal drug.3. The method of claim 1 , wherein the OprF/I agent is administered twice to the subject at an amount of 100 mcg.4. The method of claim 1 , wherein the OprF/I agent is administered to the subject at least 2 weeks before admission to the hospital.5. The method of claim 1 , wherein the OprF/I agent comprises a polypeptide selected from the group consisting of polypeptides with SEQ ID NOs: 1 to 13.6. The method of claim 1 , wherein the OprF/I agent comprises a polypeptide a polypeptide of SEQ ID NO: 1.7. The method of claim 1 , wherein the OprF/I agent comprises a protein complex claim 1 , wherein the protein complex is a trimer of OprF/I fusion proteins of SEQ ID NO: 1 or functional active variants thereof having at least 85% identity to the amino acid sequence of SEQ ID NO: 1.8. The method of claim 1 , wherein at least 80% of the OprF/I agent ...

ALUMINUM COMPOUNDS FOR USE IN THERAPEUTICS AND VACCINES

The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition. 1. A method for preparing an aqueous composition comprising aluminum , a reactive compound and a protein said method comprisingpreparing or selecting an aluminum salt that is able to provide an aqueous composition having less than 350 ppb heavy metal based on the weight of the aqueous composition andcombining said aluminum salt, said reactive compound, said protein and water to produce said aqueous composition.2. A method according to claim 1 , further comprising buffering said aqueous composition at a pH of between 6.5 and 8.5.3. A method according to claim 1 , further comprising packaging aliquots of said aqueous composition having less than 350 ppb heavy metal based on the weight of the aqueous composition in separate air-tight storage containers.4. (canceled)5. An aqueous composition comprising a protein and an aluminum salt claim 1 , said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.6. An aqueous composition according to claim 5 , which has been stored at temperatures higher than 20° C. for at least 1 month.7. An aqueous composition according to claim 5 , wherein said heavy metal is selected from Cu claim 5 , Ni claim 5 , W claim 5 , Co claim 5 , Os claim 5 , Ru claim 5 , Cd claim 5 , Ag claim 5 , Fe claim 5 , V claim 5 , Cr claim 5 , Pb claim 5 , Rb and Mo.8. An aqueous composition according to claim 5 , wherein said heavy metal is selected from Cu claim 5 , Ni claim 5 , W claim 5 , Co claim 5 , Os claim 5 , Ru claim 5 , Cd claim 5 , Ag claim 5 , Fe and V.9. An aqueous ...

METHOD OF PRODUCING PHARMACEUTICAL COMPOSITIONS COMPRISING IMMUNOGENIC CHIKUNGUNYA VIRUS CHIKV-DELTA5NP3

The present invention relates to a process for producing an immunogenic live attenuated Chikungunya virus, as well as pharmaceutical compositions comprising the same. 1. A pharmaceutical composition comprising:(i) CHIKV-Δ5nsP3 particles expressing an E2 structural protein as defined by the amino acid sequence of SEQ ID NO: 2;(ii) CHIKV-Δ5nsP3 particles expressing an E2 structural protein having a mutation E168K in the amino acid sequence of SEQ ID NO: 2; and(iii) optionally a pharmaceutically acceptable excipient,wherein 1-50% of the CHIKV-Δ5nsP3 particles present in the composition express the E2 structural protein having the E168K mutation.2. The pharmaceutical composition according to claim 1 , wherein said composition induces neutralizing antibodies against CHIKV-Δ5nsP3 in a mouse immunized with said pharmaceutical composition resulting in a serum comprising said neutralizing antibodies claim 1 , and wherein said serum neutralizes Chikungunya virus (CHIKV) infection of Vero cells at least 50% in an in vitro neutralization assay at a 1:80 serum dilution.3. The pharmaceutical composition according to claim 1 , wherein the composition induces neutralizing antibodies against CHIKV-Δ5nsP3 in a mouse immunized with said pharmaceutical composition resulting in a serum comprising said neutralizing antibodies claim 1 , and wherein said serum neutralizes Chikungunya virus (CHIKV) infection of Vero cells at least 80% in an in vitro neutralization assay at a 1:80 serum dilution.4. The pharmaceutical composition according to claim 1 , wherein the composition induces neutralizing antibodies against CHIKV-Δ5nsP3 in a mouse immunized with said pharmaceutical composition resulting in a serum comprising said neutralizing antibodies claim 1 , and wherein said serum neutralizes Chikungunya virus (CHIKV) infection of Vero cells at least 90% in an in vitro neutralization assay at a 1:80 serum dilution.5. The pharmaceutical composition according to claim 1 , wherein the composition ...

COMPUTERIZED DEVICE AND METHOD FOR PROCESSING IMAGE DATA

A computerized device () for processing image data (OCT, RID) is proposed. The computerized device () comprises a receiving unit () which is configured to receive optical coherence tomography data (OCT) of a of a tissue, in particular of a retina, a providing unit () which is configured to provide a convolutional neural network (CNN) for processing the optical coherence tomography data (OCT), and a processing unit () which is configured to process the received optical coherence tomography data (OCT) using the convolutional neural network (CNN) for identifying at least one certain object (IRC, SRF) in the tissue. 1. A computerized device for processing image data , the computerized device comprising:a receiving unit which is configured to receive optical coherence tomography data of a tissue, in particular of a retina,a providing unit which is configured to provide a convolutional neural network for processing the optical coherence tomography data, anda processing unit which is configured to process the received optical coherence tomography data using the convolutional neural network for identifying at least one certain object in the tissue.2. The computerized device of claim 1 ,wherein the processing unit is configured to localize the certain object in the optical coherence tomography data.3. The computerized device of claim 1 ,wherein the processing unit is configured to quantify a volume of the certain object in the optical coherence tomography data.4. The computerized device of one of claim 1 ,wherein the processing unit is configured to process the received optical coherence tomography data using the convolutional neural network for identifying intraretinal cystoid fluid and subretinal fluid in the received optical coherence tomography data.5. The computerized device of claim 4 ,wherein the processing unit is configured to segment and to classify the intraretinal cystoid fluid and the subretinal fluid in the received optical coherence tomography data.6. The ...

ZIKA VIRUS PURIFICATION

Described herein are processes for purifying infectious Zika virus particles and uses of protamine in such processes. 120.-. (canceled)21. A process for purifying infectious Zika virus particles , wherein said process comprises the steps of:(i) providing a crude harvest (a) comprising infectious Zika virus particles, non-infectious Zika virus particles, and impurities, wherein the impurities are generated from growing Zika virus particles on a cell substrate;(ii) contacting said crude harvest (a) with an agent comprising protamine to obtain a Zika virus preparation (b) comprising infectious Zika virus particles, wherein said agent facilitates separation of infectious Zika virus particles from non-infectious Zika virus particles; and(iii) further purifying said Zika virus preparation (b) by sucrose density gradient centrifugation;to obtain a final Zika virus preparation (c) comprising infectious Zika virus particles, less than 100 ng/mL residual host cell DNA, less than 1 μg/mL residual host cell protein, and less than 1 μg/mL residual aggregates of Zika virus particles.22. The process according to claim 21 , wherein said agent comprising protamine also facilitates the separation of infectious Zika virus particles from host cell proteins and/or low molecular weight materials.23. The process according to claim 21 , wherein the final Zika virus preparation (c) comprises less than 10 ng/mL residual host cell DNA claim 21 , less than 100 ng/mL residual host cell protein claim 21 , and less than 100 ng/mL residual aggregates of Zika virus particles.24. The process according to claim 21 , wherein said crude harvest (a) is subjected to a concentration step prior to step (ii) claim 21 , wherein said concentration step comprises ultra/diafiltration using a hollow-fiber membrane having a pore size equal to or greater than 100 kDa.25. The process according to claim 21 , wherein said agent comprising protamine comprises a protamine salt.26. The process according to claim 25 , ...

MUTANT FRAGMENTS OF OSPA AND METHODS AND USES RELATING THERETO

The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a infection and a method of immunizing a subject. 148.-. (canceled)49Borrelia. A polypeptide comprising a mutant fragment of outer surface protein A (OspA) , wherein said mutant OspA fragment is defined by SEQ ID NO: 218 , or a functional variant thereof.50. The polypeptide according to claim 49 , wherein said functional variant has at least 95% sequence identity to the wild-type OspA fragment.51. The polypeptide according to claim 49 , wherein said polypeptide comprises a heterodimer selected from the group consisting of Lip-S5D1-S6D1 (SEQ ID NO: 190) claim 49 , Lip-S6D1-S5D1 (SEQ ID NO: 196) claim 49 , S5D1-S6D4 (SEQ ID NO: 202) and S6D4-S5D1 (SEQ ID NO: 207).52. The polypeptide according to claim 49 , wherein said polypeptide consists of a heterodimer selected from the group consisting of Lip-S5D1-S6D1 (SEQ ID NO: 190) claim 49 , Lip-S6D1-S5D1 (SEQ ID NO: 196) claim 49 , S5D1-S6D4 (SEQ ID NO: 202) and S6D4-S5D1 (SEQ ID NO: 207).53. A nucleic acid molecule encoding the polypeptide according to .54. A pharmaceutical composition comprising the polypeptide according to and optionally a pharmaceutically acceptable carrier or excipient.55. The pharmaceutical composition according to claim 54 , wherein said excipient is L-methionine and/or aluminium hydroxide.56. A pharmaceutical composition comprising the nucleic acid molecule according to and optionally a pharmaceutically acceptable carrier or excipient.57. A pharmaceutical composition comprising Lip-S5D1-S6D1 (SEQ ID NO: 190) and/or Lip-S1D1-S2D1 (SEQ ID NO: 186) and claim 53 , optionally claim 53 , a pharmaceutically acceptable carrier or excipient.58. The ...

METHOD FOR INCREASING ADHESION STRENGTH BETWEEN A METAL AND AN ORGANIC MATERIAL

The present invention relates to a method for increasing adhesion strength between a surface of a metal, a metal alloy or a metal oxide and a surface of an organic material comprising as a main step contacting of at least one section of said metal, metal alloy or metal oxide with a specific azole silane compound, a specific azole silane oligomer, or a mixture comprising said compound and/or said oligomer. Furthermore, the present invention relates to a use of said specific azole silane compound, said specific azole silane oligomer, or said mixture in a method for increasing adhesion strength between a surface of a metal, a metal alloy or a metal oxide and a surface of an organic material. 2. The method according to claim 1 , wherein an aqueous solution of the azole silane compound of formula (I) and/or the azole silane oligomer is used in step (ii).3. The method according to claim 2 , wherein the aqueous solution further comprises one or more than one water miscible organic solvent.4. The method according to claim 3 , wherein the one or more than one water miscible organic solvent comprises a water-miscible organic solvent selected from the group consisting of C1 to C4 alcohols claim 3 , glycol ethers claim 3 , and mixtures thereof.5. The method according to claim 2 , wherein the total amount of the azole silane compounds and the azole silane oligomers together is 5 wt.-% or less claim 2 , based on the total weight of the aqueous solution.6. The method according to claim 2 , wherein the aqueous solution has a pH in the range from 4.8 to 8.6.7. The method according to additionally comprising the following step before conducting step (ii):(i-a) contacting the at least one section of said metal, metal alloy or metal oxide with an etch-cleaning solution.8. The method according to additionally comprising the following step before conducting step (ii):(i-b) contacting the at least one section of said metal, metal alloy or metal oxide with a etch-cleaning solution.9. The ...

ALUMINUM COMPOUNDS FOR USE IN THERAPEUTICS AND VACCINES

The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition. 1. A method for preparing an aqueous composition comprising aluminium , a reactive compound and a protein antigen , said method comprisingselecting an aluminium-salt that is able to provide an aqueous composition having less than 1.25 ppb Cu based on the weight of the aqueous composition andcombining said aluminium salt, said reactive compound, said protein antigen and water to produce said aqueous composition.2. A method according to claim 1 , further comprising buffering said aqueous composition at a pH of between 6.5 and 8.5.3. A method according to claim 1 , further comprising packaging aliquots of said aqueous composition in separate air-tight storage containers.4. A method for preparing a clinical grade aluminium-salt precipitate for incorporation into a medicament and/or vaccine claim 1 , said method comprising preparing an aqueous solution of aluminium ions and precipitating said aluminium-ions from said solution claim 1 , and determining the level of a heavy metal in the solution and/or the aluminium-salt precipitate claim 1 , wherein the precipitate is selected that is able to provide an aqueous composition comprising less than 1.25 ppb Cu based on the weight of the aqueous composition.526.-. (canceled)27. A method according to claim 1 , wherein the reactive compound is selected from the group consisting of a redox active compound claim 1 , a radical building compound claim 1 , a stabilizing compound and a combination of any thereof.28. A method according to claim 1 , wherein the protein antigen is a protein of the Japanese ...

ASEPTIC PURIFICATION PROCESS FOR VIRUSES

Described herein are processes for the purification of viruses and compositions thereof. 1. A process of purification of virus particles comprising the steps of:(a) providing a liquid medium comprising virus particles, wherein the virus particles are greater than about 100 nm in diameter;(b) contacting the virus particles with a solid-phase matrix comprising a ligand-activated core and an inactive shell comprising pores, wherein the molecular weight cut off of the pores excludes the virus particles from entering the ligand-activated core, and wherein a molecule smaller than the molecular weight cut off of the pores can enter the ligand-activated core; and 'wherein the process is performed aseptically.', '(c) separating the solid-phase matrix from the virus particles by filtration to produce a final virus preparation;'}2. The process of claim 1 , wherein the liquid medium comprising the virus particles is subjected to one or more pre-purification step(s) prior to step (b).3. The process of claim 1 , wherein the virus particles are about 200 nm claim 1 , 300 nm claim 1 , 400 nm claim 1 , 500 nm or more in diameter.4. The process of claim 1 , wherein the molecule entering the core of the solid-phase matrix has a molecular weight less than 700 kDa.5. (canceled)6. The process of claim 1 , wherein the ligand of the ligand-activated core of the solid-phase matrix is octylamine.7. (canceled)8. (canceled)9. The process of claim 1 , wherein the relative reduction of impurity of the final virus preparation relative to the liquid medium comprising the plurality of the viruses or virus particles is in a range from 60 to 95%.10. (canceled)11. The process of claim 2 , wherein the pre-purification step comprises(a) digesting host cell genomic DNA in the liquid medium comprising the plurality of the viruses or virus particles by enzymatic treatment; and/or(b) ultra/diafiltration of the liquid medium comprising the plurality of the viruses or virus particles using a hollow fiber ...

ZIKA VIRUS VACCINE

Described herein are Zika virus vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof. 117-. (canceled)18. A Zika virus immunogenic composition comprising a Zika virus having an RNA genome corresponding to the DNA sequence provided by SEQ ID NO: 72 , or a sequence with at least 95% sequence identity to the sequence provided by SEQ ID NO: 72.19. The Zika virus immunogenic composition according to claim 18 , wherein the Zika virus has an RNA genome corresponding to a DNA sequence with at least 96% claim 18 , 97% claim 18 , 98% claim 18 , or at least 99% sequence identity to the sequence provided by SEQ ID NO: 72.20. The Zika virus immunogenic composition according to claim 18 , wherein the immunogenic composition is capable of stimulating a neutralizing antibody titer greater than 15 in at least 70% of vaccinated subjects claim 18 , wherein the neutralizing antibody titer is determined using a microneutralization assay (MN).21. The Zika virus immunogenic composition according to claim 20 , wherein said MNis greater than 20 claim 20 , 25 claim 20 , 30 claim 20 , 35 claim 20 , 40 claim 20 , or 45.22. The Zika virus immunogenic composition according to claim 18 , wherein the immunogenic composition is capable of stimulating a neutralizing antibody titer greater than 15 in at least 75% claim 18 , 80% claim 18 , 90% claim 18 , 95% claim 18 , 96% claim 18 , 97% claim 18 , 98% claim 18 , or at least 99% of vaccinated subjects.23. The Zika virus immunogenic composition according to claim 18 , wherein the immunogenic composition contains protamine sulphate (PS) or fragments or break-down products of PS at amounts below 1 μg/mL and wherein the immunogenic composition is able to confer seroprotection on at least 70% of subjects that are administered the immunogenic composition.24. The Zika virus immunogenic composition according to claim 23 , wherein the immunogenic composition contains protamine sulphate (PS) or fragments ...

Computerized Device and Method for Processing Image Data

A computerized device for processing image data is proposed. The computerized device comprises a receiving unit a receiving unit which is configured to receive optical coherence tomography data of a tissue of a patient, in particular of a retina, a providing unit which is configured to provide a prediction model for processing the optical coherence tomography data, and a processing unit which is configured to process the received optical coherence tomography data using the prediction model for providing at least one prediction parameter for predicting prospective objects of the tissue and/or prospective features allocated to the tissue. 1. A computerized device for processing image data , the computerized device comprising:a receiving unit which is configured to receive optical coherence tomography data of a tissue of a patient, in particular of a retina,a providing unit which is configured to provide a prediction model for processing the optical coherence tomography data, anda processing unit which is configured to process the received optical coherence tomography data using the prediction model for providing at least one prediction parameter for predicting prospective objects of the tissue and/or prospective features allocated to the tissue.2. The computerized device of claim 1 ,wherein the receiving unit is configured to receive a plurality of different optical coherence tomography data of one patient at different times and/or a plurality of different optical coherence tomography data of different patients.3. The computerized device of claim 2 ,wherein the providing unit is configured to normalize all the received optical coherence tomography data by transforming all the received optical coherence tomography data into a joint reference coordinate system.4. The computerized device of claim 1 ,wherein the objects include at least one of an intraretinal fluid, intraretinal cystoid fluid, a subretinal fluid, a druse, a pseudodruse, a retinal layer, a choroidal layer, ...

COMPRESSOR WHEEL

A compressor wheel for an internal combustion engine may include a plurality of blades which in a circumferential direction of the wheel are spaced from one another. The plurality of blades may respectively include an inflow edge which during operation are subject to an inflow of a compressible fluid substantially axially to the wheel axis. The plurality of blades may include a surface layer of locally distinct materials to adapt to locally distinct loads during operation. 1. A compressor wheel for an internal combustion engine , comprising: a plurality of blades which in a circumferential direction of the wheel are spaced from one another , the plurality of blades respectively including an inflow edge which during operation are subjected to an inflow of a compressible fluid substantially axially to the wheel axis , wherein the plurality of blades include a surface layer of locally distinct materials adapt to locally distinct loads during operation.2. The compressor wheel according to claim 1 , wherein the blades respectively include at least one of an anti-corrosively coated surface and a region on the inflow edge provided with an armour.3. The compressor wheel according to claim 1 , wherein at least one blade on the inflow edge includes a first region having at least one of a first surface material and a first coating claim 1 , and a second region arranged adjacently in an axial direction of the wheel having at least one of a second surface material and a second coating.4. The compressor wheel according to claim 3 , wherein at least one of the first surface material is formed via a plasma electrolytic oxidation (PEO) layer and the second surface material is formed via an anodised layer.5. A compressor wheel according to claim 3 , wherein the first surface material in the axial direction of the compressor wheel extends over a length having a dimension of which is approximately 10 to 40% of an axial blade length.6634. The compressor wheel according to claim 1 , ...

CHIKUNGUNYA VACCINE FORMULATIONS

The present invention is related to novel liquid and lyophilized formulations of Chikungunya virus useful as vaccines and methods for their preparation. 1. A liquid frozen or lyophilized live chikungunya vaccine formulation comprising: a) an effective amount of at least one strain of live chikungunya virus; b) about 1 to 50% (w/v) sugar; c) about 1 mM to about 20 mM phosphate; d) about 1 mM to about 50 mM of at least one carboxylate buffering agent; e) optionally about 1 mM to about 10 mM MgCl; f) optionally about 0.1% to about 5% (w/v) D-sorbitol; g) optionally about 1 mM to 20 mM L-methionine; and h) optionally about 0.001% to about 0.1% (w/v) human serum albumin.2. The formulation of claim 1 , wherein the human serum albumin is a recombinant human serum albumin (rHSA).3. The formulation according to any preceding claims wherein said at least one carboxylate buffering agent is selected from the group consisting of succinate claim 1 , citrate claim 1 , fumarate claim 1 , tartarate claim 1 , maleate and lactate.4. The formulation according to any preceding claims wherein said sugar is selected from the group consisting of sucrose claim 1 , mannitol claim 1 , lactose claim 1 , sorbitol claim 1 , dextrose claim 1 , fucose and trehalose claim 1 , preferably sucrose or trehalose claim 1 , most preferably sucrose.5. The formulation according to any preceding claims wherein the concentration of sugar is between about 1 to about 10%; the concentration of phosphate is between about 1 to about 10 mM; and said at least one carboxylic acid is citrate or succinate at a concentration between about 10 to about 30 mM.6. The formulation according to any preceding claims further comprising: k) at least one diluent selected from the group consisting of tissue culture medium claim 1 , saline and water to volume.7. The formulation according to any preceding claims wherein the pH is between about pH 5.0 to about pH 8.0 claim 1 , preferably between pH 7.0 and pH 7.5 claim 1 , most ...

Inactivation process for viruses

Described herein are methods for inactivation of viruses with high yield and recovery, and compositions produced by such methods.

TURBINE HOUSING FOR AN EXHAUST GAS TURBOCHARGER

A turbine housing for an exhaust gas turbocharger may include a wastegate valve that may have at least two apertures. A first aperture may be configured to receive a wastegate shaft and a second aperture may be configured as an inlet to a bypass channel. An insert may include a valve seat for the wastegate valve and a bearing bush for mounting the wastegate shaft. The valve seat may be mounted by a matching valve disc. The valve seat may cover the second aperture and the bearing bush may cover the first aperture in an installed state of the insert. 120.-. (canceled)21. A turbine housing for an exhaust gas turbocharger , comprising:a wastegate valve including at least two apertures, a first aperture configured to receive a wastegate shaft and a second aperture configured as an inlet to a bypass channel;an insert including a valve seat for the wastegate valve and a bearing bush for mounting the wastegate shaft, wherein the valve seat is mounted by a matching valve disc;wherein the valve seat covers the second aperture and the bearing bush covers the first aperture in an installed state of the insert.22. The turbine housing according to claim 21 , wherein at least one of the turbine housing is composed of at least two sheet metal parts and the turbine housing is composed of an aluminum casting.23. The turbine housing according to claim 22 , wherein the insert includes at least one of a greater wall thickness and a greater strength than the at least two sheet metal parts.24. The turbine housing according to claim 21 , wherein the insert is configured as a shaped sheet metal part.25. The turbine housing according to claim 24 , wherein the insert is connected to the turbine housing via being at least one of screwed claim 24 , soldered claim 24 , welded and adhered.26. The turbine housing according to claim 21 , wherein the insert is configured as a shaped metal angle having a first leg on one end and a second leg on another end claim 21 , wherein the valve seat is ...

IC31 NANOPARTICLES

The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKLKLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)and wherein the peptide and the oligodeoxynucleotide are present as sterile-filterable nanoparticles in the composition, thereby forming a suspension, characterized in that the mean particle size of the solid particles is less than 1 μm. 115.-. (canceled)16. A method of producing a pharmaceutical composition in an aqueous mixture form , wherein the pharmaceutical composition comprises a peptide with the amino acid sequence KLKLKLK (SEQ ID NO:1) and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)(SEQ ID NO:2) wherein the peptide and the oligodeoxynucleotide are present as stable complexes , characterized in thatthe peptide is present at a concentration of at least 100 nmol/mL and the oligodeoxynucleotide is present at a concentration of at least 4 nmol/mL,the molar ratio of the peptide to the oligodeoxynucleotide is between 20:1 and 50:1,the mean particle size of the stable complexes comprising the peptide and the oligodeoxynucleotide is less than 1 μm,the sodium ion concentration is from 0 to 25 mM,{'sup': '2+', 'the composition optionally comprises Ca ions, phosphate ions, citrate ions or acetate ions at a concentration of less than 1 mM each,'}optionally, the composition comprises a buffer system or a combination of buffer systems, with a pH of 5.5-9.5,optionally, the composition has a viscosity of less than 15 cP, andoptionally, the composition is sterile.17. The method according to claim 16 , wherein the optional buffer system comprises a Tris claim 16 , a Histidine claim 16 , a carbonate claim 16 , a bicarbonate claim 16 , a 2-(N-morpholino) ethanesulfonic acid (MES) or a 3-(N-morpholino) propanesulfonic acid (MOPS) buffer system.18. The method according to claim 16 , wherein the buffer system comprises 1-50 mM Tris claim 16 , pH 6-9 claim 16 , 5 mM MES claim ...

VIRUS PURIFICATION

Described herein are improved purification methods for virus vaccines and compositions. Also described are Zika, Chikungunya, dengue and yellow fever vaccines and methods of producing and administering said vaccines to subjects in need thereof. 137.-. (canceled)38. A method for removal of protamine from purified infectious Chikungunya virus particles , comprisingsubjecting the purified Chikungunya virus particles to sucrose gradient centrifugation comprising a sucrose gradient, wherein the sucrose gradient comprises a Chikungunya virus comprising fraction in a 10%+/−1% (w/w) sucrose solution and three further layers of sucrose solutions with different densities, wherein the three further layers of sucrose solutions comprise a first sucrose solution with 15%+/−1% (w/w) sucrose, a second sucrose solution with 35% +/−1% (w/w) sucrose, and a third sucrose solution with 50%+/−1% (w/w) sucrose.39. A method for purification of infectious Chikungunya virus particles , comprising the steps ofi) providing a crude harvest (a) comprising virus particles and impurities, wherein the impurities are generated from growing said virus particles on a cell substrate;ii) reducing impurities from said crude harvest (a) by precipitation with an agent comprising protamine to obtain a virus preparation (b);iii) further purifying said virus preparation (b) by sucrose density gradient centrifugation to obtain a Chikungunya virus preparation (c), wherein the sucrose gradient is provided such that the protamine can be completely or almost completely separated from the virus fraction; and wherein the protamine concentration is reduced by this step to the extent that the protamine concentration in the final drug substance is below 1 μg/ml, and wherein said sucrose gradient comprises a Chikungunya virus comprising fraction in a 10%+/−1% (w/w) sucrose solution and three further layers of sucrose solutions with different densities, wherein the three further layers of sucrose solutions comprise a ...

MUTANT FRAGMENTS OF OspA AND METHODS AND USES RELATING THERETO

The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a infection and a method of immunizing a subject. 117-. (canceled)18. A method for producing a polypeptide comprising a mutant fragment of an outer surface protein A (OspA) , characterized by the following steps:a) introducing a vector encoding the polypeptide into a host cell,b) growing the host cell under conditions allowing for expression of said polypeptide,c) homogenizing said host cell, andd) subjecting the host cell homogenate to purification steps.1948-. (canceled)49. The method according to claim 18 , wherein the polypeptide comprises a polypeptide selected from the group of amino acid sequences of SEQ ID NO: 185 to 208; or any functional variant of said amino acid sequences claim 18 , wherein said functional variant has a sequence identity of at least 80% to any of the sequences of SEQ ID NO: 185 to 208.50. The method according to claim 18 , wherein the polypeptide comprises a heterodimer selected from the group consisting of Lip-S1D4-S2D4 (SEQ ID NO: 185) claim 18 , Lip-S1D1-S2D1 (SEQ ID NO: 186) claim 18 , Lip-S3D4-S4D4 (SEQ ID NO: 187) claim 18 , Lip-S3D1-S4D1 (SEQ ID NO: 188) claim 18 , Lip-S5D4-S6D4 (SEQ ID NO: 189) claim 18 , Lip-S5D1-S6D1 (SEQ ID NO: 190) claim 18 , Lip-S2D4-S1D4 (SEQ ID NO: 191) claim 18 , Lip-S2D1-S1D1 (SEQ ID NO: 192) claim 18 , Lip-S4D4-S3D4 (SEQ ID NO: 193) claim 18 , Lip-S4D1-S3D1 (SEQ ID NO: 194) claim 18 , Lip-S6D4-S5D4 (SEQ ID NO: 195) claim 18 , Lip-S6D1-S5D1 (SEQ ID NO: 196) claim 18 , Lip-S1D4-S2D1 (SEQ ID NO: 197) claim 18 , Lip-S1D1-S2D4 (SEQ ID NO: 198) claim 18 , S3D4-S4D1 (SEQ ID NO: 199) claim 18 , S3D1-S4D4 (SEQ ID NO: 200) claim 18 , S5D4-S6D1 (SEQ ID NO: 201) claim ...

AZOLE SILANE COMPOUND

The present invention relates to a specific azole silane compound, an oligomer thereof, a mixture comprising said compound and/or said oligomer, as well as a respective storage and working solution. Furthermore, the present invention relates to a synthesis method for said specific azole silane compound, and the use of said working solution as a surface treatment solution. 2. The compound of claim 1 , wherein X denotes NH claim 1 , NH(NH) claim 1 , SH claim 1 , SCH claim 1 , or OCH.3. The compound of claim 1 , wherein in U n is an integer in the range from 1 to 8.6. The oligomer according to claim 5 , wherein the oligomer is selected from the group consisting of an azole silane dimer claim 5 , an azole silane trimer claim 5 , and an azole silane tetramer.10. The storage solution according to claim 9 , wherein in the solution the total amount of all azole silane compounds and all azole silane oligomers together is in the range from 0.5 wt.-% to 15 wt.-% claim 9 , based on the total weight of the alkaline storage solution.12. The alkaline storage solution according to claim 9 , wherein the one or more than one water miscible organic solvent comprises a water-miscible organic solvent selected from the group consisting of C1 to C4 alcohols claim 9 , glycol ethers claim 9 , and mixtures thereof.14. The method of claim 13 , wherein the total molar ratio of the compound of formula (III) to the compound of formula (IV) is in the range from 1:0.85 to 1:1.3.15. A method of preparing a surface comprising a metal claim 11 , an organic material claim 11 , or both a metal and an organic material claim 11 , comprising applying to the surface the aqueous working solution according to .16. The alkaline storage solution according to claim 10 , wherein the one or more than one water miscible organic solvent comprises a water-miscible organic solvent selected from the group consisting of C1 to C4 alcohols claim 10 , glycol ethers claim 10 , and mixtures thereof.17. The aqueous working ...

MUTANT FRAGMENTS OF OSPA AND METHODS AND USES RELATING THERETO

The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a infection and a method of immunizing a subject. 148.-. (canceled)49Borrelia. A polypeptide comprising a mutant fragment of a outer surface protein A (OspA) , wherein said mutant OspA fragment comprises SEQ ID NO: 216 , or a variant thereof , wherein said variant has at least 95% sequence identity to a wild-type serotype 1 OspA fragment defined by amino acid residues 126-273 of SEQ ID NO: 20 , and wherein said variant differs from said wild-type serotype 1 OspA fragment at least by the addition of at least one disulfide bond.50. The polypeptide according to claim 49 , wherein said polypeptide comprises a heterodimer selected from the group consisting of Lip-S1D1-S2D1 (SEQ ID NO: 186) claim 49 , Lip-S2D1-S1D1 (SEQ ID NO: 192) claim 49 , Lip-S1D1-S2D4 (SEQ ID NO: 198) claim 49 , and Lip-S2D4-S1D1 (SEQ ID NO: 203).51. The polypeptide according to claim 49 , wherein said polypeptide consists of a heterodimer selected from the group consisting of Lip-S1D1-S2D1 (SEQ ID NO: 186) claim 49 , Lip-S2D1-S1D1 (SEQ ID NO: 192) claim 49 , Lip-S1D1-S2D4 (SEQ ID NO: 198) claim 49 , and Lip-S2D4-S1D1 (SEQ ID NO: 203).52. A pharmaceutical composition comprising the polypeptide according to .53. The pharmaceutical composition of claim 52 , further comprising a pharmaceutically acceptable carrier or excipient.54. The pharmaceutical composition according to claim 53 , wherein said excipient is L-methionine and/or aluminium hydroxide.55. A pharmaceutical composition comprising Lip-S1D1-S2D1 (SEQ ID NO: 186) and Lip-S5D1-S6D1 (SEQ ID NO: 190).56. The pharmaceutical composition of claim 55 , further comprising a pharmaceutically acceptable ...

PROCESS SUPPORT SYSTEM AND METHOD

A process support system may include a processor for providing a sequence of subprocesses of a process, each being assigned an indication about a desired state, an actuator for providing information, which is presented to a user, about the subprocesses that are to be performed in accordance with the indication, a sensor for detecting a state brought about by the user, the state being linked to the subprocess, a comparator for comparing the detected state with the desired state of the respective subprocess. For the case the subprocess was not performed correctly, the processor provides a correction subprocess, and, for the case the subprocess was performed correctly, the processor provides a subprocess which succeeds the subprocess. The processor assigns to the correction subprocess an indication about a desired correction state, and the comparator compares the detected state with the desired correction state of the respective correction subprocess. 1. A process support system for processing an object , the process support system comprising:a processor, designed for providing a predefined sequence of subprocesses of a process for processing an object, wherein the sequence of subprocesses of the process is stored, wherein each subprocess is assigned an indication about at least one desired action or at least one desired state as result of the respective subprocess;at least one actuator for providing information, which is presented to a user, about the individual subprocesses of the process that are to be performed in accordance with the indication provided by the processor;at least one sensor for detecting an action carried out by the user and/or a state on account of the action carried out by the user, wherein the action and/or the state are/is linked to the subprocess which is respectively to be performed and concerning which the information was provided by means of the at least one actuator; anda comparator, designed for comparing the detected action or the ...

NOVEL ADHESION PROMOTING AGENTS FOR METALLIZATION OF SUBSTRATE SURFACES

A method is provided for metallization of substrates providing a high adhesion of the deposited metal to the substrate material and thereby forming a durable bond. The method applies novel adhesion promoting agents comprising nanometer-sized particles prior to metallization. The particles have at least one attachment group bearing a functional chemical group suitable for binding to the substrate. 1. Method for plating a metal onto a substrate comprising the steps ofi. contacting the substrate with a solution containing nanometer-sized particles having at least one attachment group bearing a functional chemical group suitable for binding to the substrate, and forming a layer of said nanometer-sized particles bound to at least a portion of a surface of the substrate; and thereafterii. metal plating the substrate by applying a wet-chemical plating method,and wherein the layer of said nanometer-sized particles remain between the substrate surface and the plated metal, {'br': None, '-B-L-FG\u2003\u2003(I),'}, 'wherein the at least one attachment group has the general Formula (I)'}wherein B is a binding group, L is a linking group and FG is the functional chemical group, andwherein the binding group B represents{'sup': 1', '2', '1', '2, 'a. —Si(RR)—, wherein Rand Rindependently of each other represent alkoxy groups having from 1 to 12 carbon atoms, alkyl groups having from 1 to 12 carbon atoms, halogen atoms and a bond to oxygen atoms originating from the nanometer-sized particle and/or further attachment groups; or'}{'sub': 2', '2', '2, 'sup': 3', '3, 'b. —CH—R—, —CO—NH—, —CO—O—, unsubstituted or substituted aryl, wherein Rrepresents —CHOH—CH—O—, —CHOH—CH—; a linear unsubstituted or substituted hydrocarbon group having from 1 to 5 carbon atoms.'}2. (canceled)3. (canceled)4. Method according to wherein the linking group L represents a linear claim 1 , unsubstituted or substituted hydrocarbon group having from 1 to 20 carbon atoms; a cyclic claim 1 , unsubstituted or ...

LEAKAGE MONITORING SYSTEM FOR SPACE-ENCLOSING OBJECTS AND COUPLING REGIONS LOCATED THERE BETWEEN

A leakage monitoring system is provided for space-enclosing objects, such as pipes, hoses or containers having an exterior wall. The leakage monitoring system includes at least one electrically conductive element that acts as a leakage sensor and is mounted on the exterior wall or integrated therein. In order to make simple and reliable monitoring of imminent or already occurring leakages possible, even for extensive wall regions, and specifically in as universal a manner as possible for different types of media, the electrically conductive element is a component of a measuring bridge which contains a device for evaluating the bridge voltage and which is powered by a voltage source has an operating voltage containing both AC voltage components and DC voltage components. 1. A leakage monitoring system for a space-enclosing object having an exterior wall , the leakage monitoring system comprising:a measuring bridge having at least one electrically conductive element acting as a leakage sensor mounted on the exterior wall or integrated therein;a voltage source outputting an operating voltage containing both AC voltage components and DC voltage components for powering said measuring bridge; anda device for evaluating a bridge voltage, said evaluation device configured to measure both a change in amplitude and a change in signal shape.2. The leakage monitoring system according to claim 1 , further comprising means for switching between at least two different base frequencies.3. The leakage monitoring system according to claim 1 , wherein said evaluation device has an electronic processing device for evaluating the bridge voltage.4. The leakage monitoring system according to claim 1 , wherein said evaluation device contains an alarm signalling device and a diagnostic device connected to said alarm signalling device.5. The leakage monitoring system according to claim 1 , wherein the exterior wall is made claim 1 , at least predominantly claim 1 , of a plastic material.6. ...

ALUMINUM COMPOUNDS FOR USE IN THERAPEUTICS AND VACCINES

The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition. 13.-. (canceled)4. A method for preparing a clinical grade aluminum salt precipitate for incorporation into a medicament and/or vaccine , said method comprisingpreparing an aqueous solution of aluminum ions and precipitating said aluminum-ions from said solution to form an aluminum salt precipitate, anddetermining the level of copper (Cu) in the solution and/or the aluminum salt precipitate, wherein the precipitate is selected that is able to provide an aqueous composition comprising less than 3 ppb Cu based on the weight of the aqueous composition.526.-. (canceled)27. The method of claim 4 , wherein the precipitate is selected that is able to provide an aqueous composition comprising less than 2.5 ppb Cu based on the weight of the aqueous composition.28. The method of claim 27 , wherein the precipitate is selected that is able to provide an aqueous composition comprising less than 1.25 ppb Cu based on the weight of the aqueous composition.28. The method of claim 27 , further comprising determining the level of iron (Fe) in the solution and/or the aluminum salt precipitate claim 27 , wherein the precipitate is selected that is able to provide an aqueous composition comprising between 5 ppb and 250 ppb Fe based on the weight of the aqueous composition.29. The method of claim 27 , further comprising determining the level of nickel (Ni) in the solution and/or the aluminum salt precipitate claim 27 , wherein the precipitate is selected that is able to provide an aqueous composition comprising less than 40 ppb Ni based on the weight of the ...

ALUMINUM COMPOUNDS FOR USE IN THERAPEUTICS AND VACCINES

The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition. 1. An aqueous composition comprising a protein and an aluminum-salt , said composition comprising less than 1.25 ppb Cu based on the weight of the aqueous composition , and wherein said protein is protein within formaldehyde inactivated virus particles.2. An aqueous composition according to claim 1 , which has been stored at temperatures higher than 20° C. for at least 1 month.3. An aqueous composition according to claim 1 , comprising less than 350 ppb heavy metal claim 1 , wherein said heavy metal is selected from Ni claim 1 , W claim 1 , Co claim 1 , Os claim 1 , Ru claim 1 , Cd claim 1 , Ag claim 1 , Fe claim 1 , V claim 1 , Cr claim 1 , Pb claim 1 , Rb and Mo.4. An aqueous composition according to claim 1 , comprising less than 350 ppb heavy metal claim 1 , wherein said heavy metal is selected from Ni claim 1 , W claim 1 , Co claim 1 , Os claim 1 , Ru claim 1 , Cd claim 1 , Ag claim 1 , Fe claim 1 , V.5. An aqueous composition according to claim 1 , comprising less than 350 ppb heavy metal claim 1 , wherein said heavy metal is selected from Ni.6. An aqueous composition according to claim 1 , comprising less than 350 ppb heavy metal claim 1 , wherein said heavy metal is present in ionic form.7. An aqueous composition according to claim 1 , wherein the aluminum-salt is aluminum hydroxide (Al(OH)3) or aluminum phosphate (AlPO4).8. An aqueous composition according to claim 1 , wherein the aluminum-salt is aluminum hydroxide (Al(OH)3).9. An aqueous composition according to claim 1 , further comprising a reactive compound selected from the ...

SECURITY ELEMENT FOR AN OBJECT SURFACE

A security element for an object surface separated by a vertical distance, in particular an object height, from a floor area, includes a longitudinally extending flat support body including a first and second flat side. The first flat side is designed to be placed on the object surface. A presence detector and an evaluation unit are mounted on the second flat side, and the support body is made of a flexible material. The presence detector includes a detection region spatially extending around the presence detector away from the first flat side. The detection region is formed by a near-field region, and the evaluation unit includes an electrical energy storage device. The presence detector forms a measuring unit including an electrical characteristic variable. The presence detector also includes at least two electrically conductive electrodes, the electrodes being formed substantially along the entire longitudinal extent of the support body. 112254. A security element () for an object surface () , which object surface () is at a distance from a floor surface () , due to a vertical distance , in particular an object height () or depth , comprising{'b': 6', '7', '8, 'an elongated support body () in the shape of a flat profile, having a first () and a second () flat side,'}{'b': 6', '7', '2, 'wherein the support body () is configured with the first flat side () to be placed on the object surface (),'}{'b': 9', '10', '8, 'and wherein a presence sensor () and an evaluation unit () are disposed on the second flat side (),'}{'b': 9', '27', '27', '8', '7', '9', '6, 'and wherein the presence sensor () has a detection region (), which detection region () extends, proceeding from the second flat side (), in the spatial direction of the direction facing away from the first flat side (), around the presence sensor (), and wherein the support body () is formed from a flexible material, wherein'}{'b': '27', 'the detection region () is formed by a near region, in particular by a ...

NOVEL OPRF/I FUSION PROTEINS, THEIR PREPARATION AND USE

The present invention relates to a novel trimeric OprF/I fusion protein comprising a portion of the outer membrane protein F which is fused with its carboxy terminal end to a portion of the amino terminal end of the out membrane protein I, wherein said portion of the outer membrane protein F comprises the amino acids 190-342 of SEQ ID NO: 1 and wherein said portion of the outer membrane protein I comprises the amino acids 21-83 of SEQ ID NO: 2, and further to a novel Opr F/I fusion protein which contains a disulphide bond pattern, preferably selected from the group consisting of (a) Cys18-Cys27-bond, (b) Cys18-Cys27-bond and Cys33-Cys47-bond, and (c) Cys18-Cys47 and Cys27-Cys33-bond, and to immunogenic variants thereof having at least 85% identity to the amino acid sequence of SEQ ID NO: 3. The present invention also relates to a novel method for producing said OprF/I fusion proteins and to their use for the preparation of a pharmaceutical composition and for the preparation of antibodies or antibody derivatives which specifically bind said novel OprF/I fusion proteins. 112.-. (canceled)13. An antibody or antibody derivative which specifically binds a protein complex comprising three OprF/I fusion proteins of SEQ ID NO: 4 or an immunogenic variant thereof having at least 85% identity to the amino acid sequence of SEQ ID NO: 4.14. An antibody or antibody derivative which selectively binds a protein complex comprising three OprF/I fusion proteins of SEQ ID NO: 4 or an immunogenic variant thereof having at least 85% identity to the amino acid sequence of SEQ ID NO: 4.15. A pharmaceutical composition comprising the antibody or antibody derivative according to and one or more pharmaceutically acceptable excipients.16. A pharmaceutical composition comprising the antibody or antibody derivative according to and one or more pharmaceutically acceptable excipients.17. The antibody or antibody derivative of claim 13 , wherein the OprF/I fusion proteins are selected from the ...

ASEPTIC PURIFICATION PROCESS FOR VIRUSES

Described herein are processes for the purification of viruses and compositions thereof. 1. A process of purification of virus particles wherein the virus particles belong to the Coronaviridae virus family , comprising the steps of:(a) providing a liquid medium comprising said virus particles, wherein the virus particles are greater than about 100 nm in diameter;(b) contacting the virus particles with a solid-phase matrix comprising a ligand-activated core and an inactive shell comprising pores, having a molecular weight cut off that excludes the virus particles from entering the ligand-activated core, and wherein a molecule smaller than the molecular weight cut off of the pores can enter the ligand-activated core; and(c) separating the solid-phase matrix from the virus particles to produce a final virus preparation;wherein the solid-phase matrix is added to the liquid medium comprising the virus particles at a final concentration between 2.5% (v/v) and 30% (v/v); and wherein each step of the process is performed aseptically.2. The process of claim 1 , wherein the liquid medium comprising the virus particles is subjected to one or more pre-purification step(s) prior to step (b).3. The process of claim 1 , wherein the virus particles are about 200 nm claim 1 , 300 nm claim 1 , 400 nm claim 1 , 500 nm or more in diameter.4. The process of claim 1 , wherein the molecule entering the core of the solid-phase matrix has a molecular weight less than 700 kDa.5. (canceled)6. The process of claim 1 , wherein the ligand of the ligand-activated core of the solid-phase matrix is octylamine.7. (canceled)8. (canceled)9. The process of claim 1 , wherein the relative reduction of impurity of the final virus preparation relative to the liquid medium comprising the plurality of the viruses or virus particles is in a range from 60 to 95%.10. (canceled)11. The process of claim 2 , wherein the pre-purification step comprises(i) digesting host cell genomic DNA in the liquid medium ...

ZIKA VIRUS PURIFICATION

Described herein are processes for purifying infectious Zika virus particles and uses of protamine in such processes. 1. Use of protamine , preferably a protamine salt , to separate infectious Zika virus particles from non-infectious Zika virus particles.2. The use according to claim 1 , wherein the protamine salt also facilitates the separation of infectious Zika virus particles from host cell proteins and/or low molecular weight materials.3. A process of purification of infectious Zika virus particles claim 1 , comprising the steps of:a) providing a crude harvest (a) comprising Zika virus particles and impurities, wherein the impurities are generated from growing said Zika virus particles on a cell substrate;b) reducing impurities from said crude harvest (a) by precipitation with an agent comprising protamine, preferably a protamine salt, more preferably a protamine sulphate, even more preferably a recombinant protamine sulphate, to obtain a Zika virus preparation (b), wherein the enrichment of infectious Zika virus particles in the Zika virus preparation (b) relative to total Zika virus products in the crude harvest (a) is in the range of at least 50% to 95%, preferably at least 80%.4. A process of purification of infectious Zika virus particles claim 1 , comprising the steps of:a) providing a crude harvest (a) comprising Zika virus particles and impurities, wherein the impurities are generated from growing said Zika virus particles on a cell substrate;b) reducing impurities from said crude harvest (a) by precipitation with an agent comprising protamine, preferably a protamine salt, more preferably a protamine sulphate, even more preferably a recombinant protamine sulphate, to obtain a Zika virus preparation (b);c) further purifying said Zika virus preparation (b) by one or more size exclusion methods such as (i) a sucrose density gradient centrifugation, (ii) a solid-phase matrix packed in a column comprising a ligand-activated core and an inactive shell ...

Virus purification

Described herein are processes for purifying infectious virus particles and uses of protamine in such processes.

VIRUS PURIFICATION

Described herein are improved purification methods for virus vaccines and compositions. Also described are Zika, Chikungunya, dengue and yellow fever vaccines and methods of producing and administering said vaccines to subjects in need thereof. 1. Use of an optimized sucrose gradient centrifugation for removal of protamine sulphate from purified infectious virus particles.2. The use according to claim 1 , wherein said optimized sucrose gradient centrifugation comprises a virus comprising fraction in a 10%+/−1% (w/w) sucrose solution and three further layers of sucrose solutions with different densities claim 1 , i.e. a first sucrose solution with 15%+/−1% (w/w) sucrose claim 1 , a second sucrose solution with 35%+/−1% (w/w) sucrose claim 1 , and a third sucrose solution with a 50%+/−1% (w/w) sucrose.3. A process of purification of infectious virus particles claim 1 , comprising the steps of:a) providing a crude harvest (a) comprising virus particles and impurities, wherein the impurities are generated from growing said virus particles on a cell substrate;b) reducing impurities from the crude harvest (a) by precipitation with an agent comprising protamine, preferably a protamine salt, more preferably a protamine sulphate, even more preferably a recombinant protamine sulphate, to obtain a virus preparation (b);c) further purifying the virus preparation (b) by an optimized sucrose density gradient centrifugation, wherein the optimized sucrose gradient is provided such that the protamine can be completely or almost completely separated from the virus fraction; andwherein the protamine concentration is reduced by this step to the extent that the protamine concentration in the final drug substance is below 1 μg/ml, preferably below 0.5 μg/mL, more preferably below 0.1 μg/mL, most preferably below 0.05 μg/mL.4. The process of claim 3 , wherein said optimized sucrose density gradient centrifugation comprises a virus comprising fraction in a 10%+/−1% (w/w) sucrose solution ...

ALUMINUM COMPOUNDS FOR USE IN THERAPEUTICS AND VACCINES

The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminium content. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition. 126.-. (canceled)27. An aqueous pharmaceutical composition or vaccine , comprising a protein and an aluminum salt , and wherein said aqueous pharmaceutical composition comprises less than 3 ppb heavy metal copper (Cu) based on the weight of the composition.28. The aqueous pharmaceutical composition or vaccine according to claim 27 , comprising less than 2.5 ppb heavy metal Cu based on the weight of the composition.29. The aqueous pharmaceutical composition or vaccine according to claim 27 , comprising less than 1.25 ppb heavy metal Cu based on the weight of the composition (p. 7 claim 27 , ln. 23).30. The aqueous pharmaceutical composition or vaccine according to claim 27 , comprising less than 350 ppb heavy metal based on the weight of the composition claim 27 , wherein said heavy metal is selected from the group consisting of nickel (Ni) claim 27 , tungsten (W) claim 27 , cobalt (Co) claim 27 , osmium (Os) claim 27 , ruthenium (Ru) claim 27 , cadmium (Cd) claim 27 , silver (Ag) claim 27 , iron (Fe) claim 27 , vanadium (V) claim 27 , chromium (Cr) claim 27 , lead (Pb) claim 27 , rubidium (Rb) claim 27 , and molybdenum (Mo).31. The aqueous pharmaceutical composition or vaccine according to claim 27 , comprising less than 40 ppb nickel (Ni) based on the weight of the aqueous composition.32. The aqueous pharmaceutical composition or vaccine according to claim 27 , comprising between 5 ppb and 250 ppb iron (Fe) based on the weight of the aqueous composition.33. The aqueous pharmaceutical composition or vaccine according to claim 30 , wherein ...

VIRUS PURIFICATION

Described herein are processes for purifying infectious virus particles and uses of protamine in such processes. 122.-. (canceled)23. A method for separating infectious Chikungunya virus particles from non-infectious Chikungunya virus particles comprising precipitating the non-infectious virus particles with protamine.24. The method according to claim 23 , wherein said protamine precipitation also facilitates the separation of infectious Chikungunya virus particles from host cell proteins and/or low molecular weight materials.25. A method for purifying infectious Chikungunya virus particles claim 23 , comprising the steps ofi) providing a crude harvest (a) comprising infectious Chikungunya virus particles, non-infectious Chikungunya virus particles, and impurities, wherein the impurities are generated from growing said virus particles on a cell substrate;ii) contacting said crude harvest (a) with an agent comprising protamine to obtain a Chikungunya virus preparation (b) comprising infectious Chikungunya virus particles, wherein the enrichment of infectious Chikungunya virus particles in the virus preparation (b) relative to total Chikungunya virus particles in the crude harvest (a) is in the range of at least 50% to 95%.26. The method according to claim 25 , wherein said Chikungunya virus preparation (b) is further purified by one or more size exclusion methods selected fromi) sucrose density gradient centrifugation,ii) a solid-phase matrix packed in a column comprising a ligand-activated core and an inactive shell comprising pores, wherein the pores comprise a molecular weight cut-off that excludes the virus particles from entering the ligand-activated core, and wherein a molecule smaller than the molecular weight cut-off of the pores can enter the ligand-activated core, andiii) size exclusion chromatography;to obtain a final Chikungunya virus preparation (c) comprising the infectious Chikungunya virus particles, less than 100 ng/mL residual host cell DNA, less ...

ZIKA VIRUS VACCINE

Described herein are Zika virus vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof. 117.-. (canceled)18. A Zika virus vaccine comprising a Zika virus having an RNA genome corresponding to the DNA sequence provided by SEQ ID NO: 72 or a variant nucleic acid having at least 80% identity to SEQ ID NO: 72 , wherein said Zika virus vaccine is capable of stimulating a neutralizing antibody titer greater than 15 in at least 70% of vaccinated subjects , wherein the neutralizing antibody titer is determined using a microneutralization assay (MN).19. The Zika virus vaccine according to claim 18 , wherein said MNis greater than 20 claim 18 , 25 claim 18 , 30 claim 18 , 35 claim 18 , 40 claim 18 , 45 claim 18 , preferably greater than 50 claim 18 , 55 claim 18 , 60 claim 18 , 65 claim 18 , 70 claim 18 , 75 claim 18 , 80 claim 18 , 85 claim 18 , most preferably greater than or equal to 90.20. The Zika virus vaccine according to claim 18 , wherein the Zika virus vaccine is capable of stimulating a MNtiter greater than 15 in at least 75% claim 18 , 80% claim 18 , 90% claim 18 , 95% claim 18 , 96% claim 18 , 97% claim 18 , 98% claim 18 , or at least 99% of vaccinated subjects claim 18 , preferably in at least 80% of subjects.21. The Zika virus vaccine according to claim 18 , wherein the Zika virus comprises an E protein having an amino acid sequence provided by any one of SEQ ID NOs: 14-69 claim 18 , or a variant amino acid sequence that is at least 95% identical to any one of SEQ ID NOs: 14-69 and able to pack a virulent Zika virus.22. The Zika virus vaccine according to claim 18 , wherein the Zika virus is inactivated by chemical inactivation claim 18 , thermal inactivation claim 18 , pH inactivation claim 18 , or UV inactivation.23. The Zika virus vaccine according to claim 22 , wherein the chemical inactivation comprises contacting the Zika virus with a chemical inactivation agent for longer than is required to ...

Thin Aluminum Pigments Having A Narrow Thickness Distribution, Method For Producing Same, And Use Of Aluminum Pigments

The invention relates to aluminum pigments which are at least partially coated with lubricant, wherein the aluminum pigments have a relative breadth of thickness distribution Δh of from 30% to less than 70%, as determined by a scanning electron microscope thickness count and as calculated on the basis of the corresponding cumulative breakthrough curve of the relative frequencies of occurrence, according to the formula Δh=100×(h−h)/h, and an X-ray diffractogram, measured on pigments in substantially plane-parallel orientation, having one or two main peaks which do not correspond to the [111] reflexes. 1. Platelet-like aluminum pigments having a narrow thickness distribution and at least partially coated with lubricant , wherein the pigments have{'sub': '50', 'a) a mean thickness hof from 15 nm to 75 nm as determined by a scanning electron microscope thickness count,'}{'sub': 90', '10', '50, 'b) a relative breadth of thickness distribution Δh of from 30% to less than 70%, as determined by a scanning electron microscope thickness count and as calculated on the basis of the corresponding cumulative breakthrough curve of the relative frequencies of occurrence, according to the formula Δh=100×(h−h)/h, and'}c) an X-ray diffractogram, measured on pigments in substantially plane-parallel orientation, having one or two main peaks which do not correspond to the [111] reflexes.2. The platelet-type aluminum pigments according to claim 1 , wherein said aluminum pigments are produced by grinding processes.3. The platelet-type aluminum pigments according to wherein said aluminum pigments exhibit a relative breadth of said thickness distributions Δh of from 35% to 65%.4. The platelet-type aluminum pigments as defined in claim 1 , wherein the aluminum pigments have a form factor d/hof from 200 to 1500.5. The platelet-type aluminum pigments as defined in claim 1 , wherein the X-ray diffractogram has one or two peaks of maximum intensity assignable to at least one of the [200] and [220 ...

Thin coating aluminum pigments, method for the production thereof, and use of said aluminum pigments

The invention relates to aluminum pigments which are at least partly coated with lubricant. Said aluminum pigments have a) a water spreading coefficient ranging between 40,000 and 130,000 cm2/g, b) an average thickness h of less than 100 to 30 nm, said average thickness h being calculated from the water spreading coefficient and by counting the thickness from the h50 value of the cumulative passage distribution by means of scanning electron microscopy, c) a relative range of the thickness distribution Δh of 70 to 140 percent, which is determined by counting the thickness by means of scanning electron microscopy and is calculated according to formula (I) based on the corresponding cumulative passage graph of the relative frequencies, d) a form factor d50/h of more than 200, e) a peak-to-valley value of 0.30 to 0.9, said peak-to-valley value being calculated from the specific surface that is measured according to the BET method and the spreading coefficient in accordance with formula BET value/2 x spreading coefficient. The invention further relates to a method for producing said aluminum pigments and uses thereof.

Thin opaque aluminum pigments, process for producing the same and use of the aluminum pigments

Die Erfindung betrifft Aluminiumpigmente, welche wenigstens teilweise mit Schmiermittel belegt sind, wobei die Aluminiumpigmente DOLLAR A a) einen Wasser-Spreitwert zwischen 40000 bis 130000 cm·2·/g, DOLLAR A b) eine aus dem Wasser-Spreitwert sowie eine über Dickenauszählung mit Rasterelektronenmikroskopie aus dem h¶50¶-Wert der Summendurchgangsverteilung errechnete mittlere Dicke h von unter 100 bis 30 nm, DOLLAR A c) eine über Dickenauszählung mit Rasterelektronenmikroskopie ermittelte relative Breite der Dickenverteilung DELTAh, welche anhand der entsprechenden Summendurchgangskurve der relativen Häufigkeiten nach der Formel DOLLAR F1 berechnet wird, von 70% bis 140%, DOLLAR A d) einen Formfaktor d¶50¶/h von über 200, DOLLAR A e) einen Rauwert, der sich aus der spezifischen Oberfläche, welche nach der BET-Methode gemessen wird, und dem Spreitwert nach Maßgabe der folgenden Formel BET-Wert/2 È Spreitwert berechnet wird, von 0,30 bis 0,9 DOLLAR A aufweisen. DOLLAR A Die Erfindung betrifft des weiteren ein Verfahren zur Herstellung der Aluminiumpigmente als auch Verwendungen derselben. The invention relates to aluminum pigments which are at least partially coated with lubricants, the aluminum pigments DOLLAR A a) having a water spread value between 40,000 to 130,000 cm 2. / G, DOLLAR A b) one from the water spread value and one with a thickness count Scanning electron microscopy from the h¶50¶ value of the total passage distribution calculated average thickness h of less than 100 to 30 nm, DOLLAR A c) a relative width of the thickness distribution DELTAh determined by means of thickness counting with scanning electron microscopy, which is based on the corresponding total passage curve of the relative frequencies according to the formula DOLLAR F1 is calculated from 70% to 140%, DOLLAR A d) a form factor d¶50¶ / h of more than 200, DOLLAR A e) a roughness value which results from the specific surface area, which is measured according to the BET method, and the spread ...

Lubrication

Compressor and / or turbine wheel for a secondary air conveyor

Bekannte Verdichterräder bzw. Turbinenräder für eine Sekundärluftfördereinrichtung sind in nicht bedeckter Bauweise ausgeführt, bei der ihre Schaufeln in ein Gehäuse eingebracht sind und zwischen den Schaufeln und dem Gehäuse stets ein Radialspalt vorliegt, der zu Verlusten führt. DOLLAR A Es wird vorgeschlagen, das Verdichterrad (53) und/oder das Turbinenrad (52) als Radialverdichter bzw. Radialturbine auszuführen, wobei die Flügelräder (71) von einem Raddeckel (72) überdeckt sind. DOLLAR A Das erfindungsgemäße Verdichterrad bzw. Turbinenrad ist für eine Sekundärluftfördereinrichtung für Brennkraftmaschinen vorgesehen. Known compressor wheels or turbine wheels for a secondary air conveyor are designed in uncovered construction, in which their blades are inserted into a housing and between the blades and the housing is always a radial gap, which leads to losses. DOLLAR A It is proposed to perform the compressor wheel (53) and / or the turbine wheel (52) as a radial compressor or radial turbine, wherein the impellers (71) of a wheel cover (72) are covered. DOLLAR A The compressor according to the invention or turbine wheel is provided for a secondary air conveyor for internal combustion engines.

Secondary air delivery device for an internal combustion engine

The invention relates to a secondary air delivery device, comprising a secondary air charger (14) with a compressor (15) and a turbine (16). According to said invention, the turbine (16) is driven by means of the partial vacuum, prevailing in an intake duct (5) of the internal combustion engine, and, in turn, drives the compressor (15) which delivers secondary air into an exhaust area (12) of the internal combustion engine, whereby the air, required by the compressor (15) and the turbine (16), is supplied through a common air filter (45). Said secondary air delivery device is provided for internal combustion engines, wherein secondary air is supplied to the exhaust area, in particular, during the engine start phase.

Spin generator for spin impinged inflow of compressor impeller of loading device, particularly exhaust gas turbocharger for internal combustion engine, has multiple guide blades arranged in flow channel in periphery direction

The spin generator (4) has multiple guide blades (9) arranged in a flow channel (8) in periphery direction in distributed manner. The guide blades have an in-flow sided rigid blade section (15) and an out-flow sided elastically deformable blade section (16). The rigid blade section is connected firmly with a wall limiting the flowing channel laterally. The flexible blade section is mounted at the assigned rigid blade section, and is coupled with an adjusting unit for installing the downstream flow angle.

Thin aluminum pigments with narrow thickness distribution, procedure for preparing them and use of aluminum pigments

Pigmentos de aluminio en forma de escamas con distribución de espesor estrecha, que están revestidos al menosparcialmente con lubricante, caracterizados por que presentana) un espesor promedio h50 determinado mediante recuento de espesor con microscopía electrónica debarrido de 15 a 75 nm,b) una anchura relativa de la distribución de espesor Δhdeterminada mediante recuento de espesor conmicroscopía electrónica de barrido, que se calcula por medio de la correspondiente curva de pasoacumulado de las frecuencias relativas según la fórmula Δh >= 100x(h90-h10)/h50, del 30% a menos del 70% yc) un difractograma de rayos X que se midió en pigmentos en configuración esencialmente planoparalela,con uno o dos picos principales que no corresponden a los reflejos [111].

Mixture of thin iron and aluminium effect pigments, process for preparation thereof and use thereof

The invention relates to a mixture of metallic effect pigments, the mixture comprising iron-containing metallic effect pigments and aluminium effect pigments, the iron-containing metallic effect pigments, for a thickness distribution determined via thickness counting by scanning electron microscopy (SEM) and represented as cumulative frequency distribution, having an h Fe,50 value from a range from 10 to 200 nm. The invention further relates to a process for preparing the mixture and to use thereof.

Thin, platelet-shaped iron pigments, process for their preparation and use thereof

Mixture of thin iron and aluminum effect pigments, process for their preparation and their use

Die Erfindung betrifft eine Mischung von Metalleffektpigmenten, wobei die Mischung eisenhaltige Metalleffektpigmente und Aluminiumeffektpigmente umfasst, wobei die eisenhaltigen Metalleffektpigmente bei einer über Dickenauszählung mit Rasterelektronenmikroskopie (REM) ermittelten Dickenverteilung in der Darstellung als Summenhäufigkeitsverteilung einen hFe,50-Wert aus einem Bereich von 10 bis 200 nm aufweisen. Die Erfindung betrifft ferner ein Verfahren zur Herstellung der Mischung und deren Verwendung.

Thin, platy iron pigments, method for their manufacture and use

Thin coating aluminum pigments, method for the production thereof, and use of said aluminum pigments

Plate like aluminium pigments for use in e.g. printing inks, are partially coated with lubricant where average thickness is determined by thickness counting with scanning electron microscopy

The plate-like aluminum pigments are partially coated with lubricant where average thickness is determined by thickness counting with scanning electron microscopy. Relative width of the thickness distribution is determined by thickness counting on the basis the corresponding cumulative curve of the relative frequencies from 30% to less than 70% and X-ray diffractogram which is measured on pigments plane paraller arrangement , with one or two main peaks that are not [111]-reflexes. The aluminum pigments are manufactured through grinding process. The thickness distribution delta is calculated by the formula delta h=100*(h 90-h 10)/h 50. An independent claim is also included for a method for the production of plate-like aluminum pigments which involves grinding the aluminum chips of different particle size distribution using a grinding mill in the presence of solvents and lubricants.

Mixture of thin iron and aluminium effect pigments, process for preparation thereof and use thereof

compressor

Das erfindungsgemäße Verdichterrad besitzt einen Grundkörper aus Aluminium bzw. Leichtmetall und antikorrosiv beschichtete Oberflächen an den Schaufeln, wobei insbesondere eine lokal unterschiedliche Beschichtung entsprechend lokal unterschiedlichen Beanspruchungen vorgesehen ist. The compressor according to the invention has a base made of aluminum or light metal and anticorrosive coated surfaces on the blades, in particular, a locally different coating is provided according to locally different stresses.

Turbine with a turbine wheel for an exhaust gas turbocharger of an internal combustion engine and exhaust gas turbocharger for an internal combustion engine

The invention relates to a turbine with a turbine wheel for an exhaust gas turbocharger of an internal combustion engine, which comprises a hub, provided with turbine wheel blades and auxiliary blades, whereby said auxiliary blades are arranged on the hub in exhaust channels, delimited by two turbine wheel blades. According to said invention, the dimensions of the auxiliary blades (20) are fixed, whereby the ratio between a throughput parameter of the turbine wheel blades (6) and a throughput parameter of the auxiliary blades (20) is higher than 15. Said invention is mainly provided for exhaust gas turbochargers in the automotive industry.

Thin coating aluminum pigments, method for the production thereof, and use of said aluminum pigments

The invention relates to aluminum pigments which are at least partly coated with lubricant. Said aluminum pigments have a) a water spreading coefficient ranging between 40,000 and 130,000 cm2/g, b) an average thickness h of less than 100 to 30 nm, said average thickness h being calculated from the water spreading coefficient and by counting the thickness from the h50 value of the cumulative passage distribution by means of scanning electron microscopy, c) a relative range of the thickness distribution Δh of 70 to 140 percent, which is determined by counting the thickness by means of scanning electron microscopy and is calculated according to formula (I) based on the corresponding cumulative passage graph of the relative frequencies, d) a form factor d50/h of more than 200, e) a peak-to-valley value of 0.30 to 0.9, said peak-to-valley value being calculated from the specific surface that is measured according to the BET method and the spreading coefficient in accordance with formula BET value/2 x spreading coefficient. The invention further relates to a method for producing said aluminum pigments and uses thereof.

Thin coating aluminum pigments, method for the production thereof, and use of said aluminum pigments

THIN CEILING ALUMINUM PIGMENTS, METHOD FOR THE PRODUCTION THEREOF AND THE USE OF ALUMINUM PIGMENTS

Thin covering aluminum pigments, method for the production thereof, and use of said aluminum pigments

The invention relates to aluminum pigments which are at least partly coated with lubricant. Said aluminum pigments have a) a water spreading coefficient ranging between 40,000 and 130,000 cm2/g, b) an average thickness h of less than 100 to 30 nm, said average thickness h being calculated from the water spreading coefficient and by counting the thickness from the h50 value of the cumulative passage distribution by means of scanning electron microscopy, c) a relative range of the thickness distribution .DELTA.h of 70 to 140 percent, which is determined by counting the thickness by means of scanning electron microscopy and is calculated according to formula (I) based on the corresponding cumulative passage graph of the relative frequencies, d) a form factor d50/h of more than 200, e) a peak-to-valley value of 0.30 to 0.9, said peak-to-valley value being calculated from the specific surface that is measured according to the BET method and the spreading coefficient in accordance with formula BET value/2 x spreading coefficient. The invention further relates to a method for producing said aluminum pigments and uses thereof.

Thin Covering Aluminum Pigments, Process For The Production Thereof, And Use Of Said Aluminum Pigments

The invention relates to aluminum pigments which are at least partially coated with lubricants, wherein said aluminum pigment have a) a water coverage between 40,000 and 130,000 cm 2 /g, b) a mean thickness h of less than 100 to 30 nm, as calculated from the water coverage as well as the h 50 value determined from the cumulative breakthrough curve of a scanning electron microscope thickness count, c) as determined by a scanning electron microscope thickness count, a relative width of the distribution of thicknesses Δh between 70% and 140%, which is calculated on the basis of the corresponding cumulative breakthrough curve of the relative frequencies according to the formula Δ ⁢   ⁢ h = 100 × h 90 - h 10 h 50 , , d) an aspect ratio d 50 /h of more than 200, e) a roughness value of from 0.30 to 0.9, calculated from the specific surface area, as determined by the BET test method, and the water coverage according to the following formula BET value/2×water coverage. The invention also relates to a process for the manufacture of said aluminum pigments and to the use thereof.

ALUMINUM PIGMENTS OF THIN COVERING, PROCESS FOR THE PRODUCTION OF THEMSELVES, AND USE OF ALUMINUM PIGMENTS.

THIN COVERED ALUMINUM PIGMENTS, METHOD FOR THE SAME PRODUCTION AND USE OF ALUMINUM PIGMENTS.

Pigmentos de aluminio, que están cubiertos al menos parcialmente con lubricante, caracterizados por que los pigmentos de aluminio presentan a) un valor de dispersión con agua entre 40.000 y 130.000 cm2/g, b) un grosor medio h inferior a de 100 a 30 nm calculado a partir del valor de dispersión con agua así como por recuento de grosores con microscopía electrónica de barrido del valor h50 de la distribución continua de suma, c) una anchura relativa determinada por recuento de grosores con microscopía electrónica de barrido de la distribución de grosores Δh, que se calcula mediante la curva continua de suma correspondiente de las frecuencias relativas de acuerdo con la fórmula **(Ver fórmula)** del 70% al 140%, d) un factor de forma d50/h superior a 200, donde el valor d50 se corresponde al 50% de la curva de distribución de suma continua de la extensión longitudinal d, medida y evaluada en forma de una distribución de volumen de bolas equivalentes. e) un valor de rugosidad, que se calcula a partir de la superficie específica, que se mide de acuerdo con el método BET, y el valor de dispersión de acuerdo con la siguiente fórmula Valor BET/(2 x valor de dispersión), de 0,30 a 0,9. Aluminum pigments, which are at least partially covered with lubricant, characterized in that the aluminum pigments have a) a water dispersion value between 40,000 and 130,000 cm2 / g, b) an average thickness h less than 100 to 30 nm calculated from the water dispersion value as well as by thickness counting with scanning electron microscopy of the value h50 of the continuous sum distribution, c) a relative width determined by thickness counting with scanning electron microscopy of the thickness distribution Δh, which is calculated using the corresponding continuous sum curve of the relative frequencies according to formula ** (See formula) ** from 70% to 140%, d) a d50 / h form factor greater than 200, where The value d50 corresponds to 50% of the continuous sum distribution curve of the ...

Thin coating aluminum pigments, method for the production thereof, and use of said aluminum pigments

Aluminium shot for thin, plate-shaped effect pigments, method for the production thereof, and use of same

The invention relates to an aluminium shot for thin, plate-shaped effect pigments with a narrow relative width of the thickness distribution. The shot according to the invention is characterised by a grain bond of d10 = between 0.15 and 3.0 μm and d50 = between 0.8 and 5.0 μm and d90 = between 2.0 and 8.0 μm. The invention also relates to a method for producing the aluminium shot according to the invention, and to the use of the aluminium shot according to the invention as a laser marking means or a laser weldability means for plastic materials. The invention further relates to the use of the aluminium fine shot for producing ultra-thin aluminium pigments by means of wet grinding.

Thin aluminium pigments having a narrow thickness distribution, method for producing same, and use of aluminium pigments

The invention relates to aluminium pigments which are at least partially coated with lubricant. The aluminium pigments have a relative width of the thickness distribution Δh - determined by thickness counting using scanning electron microscopy - calculated on the basis of the corresponding cumulative curve of the relative frequencies according to formula Δh = 100*(h90 - h10)/h50, of between 30% and less than 70 %, and an X-ray diffractogram which has been measured on pigments in an essentially plane-parallel arrangement, with one or two main peaks which do not correspond to the [111]-reflexes. The invention also relates to a method for producing the aluminium pigments and to the uses thereof, and to nail varnishes and printing inks containing the aluminium pigments according to the invention.

Aluminium shot for thin, plate-shaped effect pigments, method for the production thereof, and use of same

The invention relates to an aluminium shot for thin, plate-shaped effect pigments with a narrow relative width of the thickness distribution. The shot according to the invention is characterised by a grain bond of d10 = between 0.15 and 3.0 μm and d50 = between 0.8 and 5.0 μm and d90 = between 2.0 and 8.0 μm. The invention also relates to a method for producing the aluminium shot according to the invention, and to the use of the aluminium shot according to the invention as a laser marking means or a laser weldability means for plastic materials. The invention further relates to the use of the aluminium fine shot for producing ultra-thin aluminium pigments by means of wet grinding.

Thin aluminum pigments having a narrow thickness distribution, method for producing same, and use of aluminum pigments

The invention relates to aluminum pigments which are at least partially coated with lubricant, wherein the aluminum pigments have a relative breadth of thickness distribution Δh of from 30% to less than 70%, as determined by a scanning electron microscope thickness count and as calculated on the basis of the corresponding cumulative breakthrough curve of the relative frequencies of occurrence, according to the formula Δh=100×(h 90 −h 10 )/h 50 , and an X-ray diffractogram, measured on pigments in substantially plane-parallel orientation, having one or two main peaks which do not correspond to the [111] reflexes. The invention further relates to a method for the production of said aluminum pigments and to uses thereof and also to nail varnishes and printing inks containing said aluminum pigments of the invention.

Thin coating aluminum pigments, method for the production thereof, and use of said aluminum pigments

Thin coating aluminum pigments, method for the production thereof, and use of said aluminum pigments

The invention relates to aluminum pigments which are at least partly coated with lubricant. Said aluminum pigments have a) a water spreading coefficient ranging between 40,000 and 130,000 cm2/g, b) an average thickness h of less than 100 to 30 nm, said average thickness h being calculated from the water spreading coefficient and by counting the thickness from the h50 value of the cumulative passage distribution by means of scanning electron microscopy, c) a relative range of the thickness distribution Δh of 70 to 140 percent, which is determined by counting the thickness by means of scanning electron microscopy and is calculated according to formula (I) based on the corresponding cumulative passage graph of the relative frequencies, d) a form factor d50/h of more than 200, e) a peak-to-valley value of 0.30 to 0.9, said peak-to-valley value being calculated from the specific surface that is measured according to the BET method and the spreading coefficient in accordance with formula BET value/2 x spreading coefficient. The invention further relates to a method for producing said aluminum pigments and uses thereof.

Thin coating aluminum pigments, method for the production thereof, and use of said aluminum pigments

The invention relates to aluminum pigments which are at least partially coated with lubricants, wherein said aluminum pigment have a) a water coverage between 40,000 and 130,000 cm<SUP>2</SUP>/g, b) a mean thickness h of less than 100 to 30 nm, as calculated from the water coverage as well as the h<SUB>50 </SUB>value determined from the cumulative breakthrough curve of a scanning electron microscope thickness count, c) as determined by a scanning electron microscope thickness count, a relative width of the distribution of thicknesses Deltah between 70% and 140%, which is calculated on the basis of the corresponding cumulative breakthrough curve of the relative frequencies according to the formula <maths id="MATH-US-00001" num="1"> <MATH OVERFLOW="SCROLL"> <MROW> <MROW> <MROW> <MI>Delta</MI> <MO>⁢</MO> <MSTYLE> <MTEXT> </MTEXT> </MSTYLE> <MO>⁢</MO> <MI>h</MI> </MROW> <MO>=</MO> <MROW> <MN>100</MN> <MO>x</MO> <MFRAC> <MROW> <MSUB> <MI>h</MI> <MN>90</MN> </MSUB> <MO>-</MO> <MSUB> <MI>h</MI> <MN>10</MN> </MSUB> </MROW> <MSUB> <MI>h</MI> <MN>50</MN> </MSUB> </MFRAC> </MROW> </MROW> <MO>,</MO> <MO>,</MO> </MROW> </MATH> </MATHS> d) an aspect ratio d<SUB>50</SUB>/h of more than 200, e) a roughness value of from 0.30 to 0.9, calculated from the specific surface area, as determined by the BET test method, and the water coverage according to the following formula BET value/2xwater coverage. The invention also relates to a process for the manufacture of said aluminum pigments and to the use thereof.

Thin aluminium pigments having a narrow thickness distribution, method for producing same, and use of aluminium pigments

The invention relates to aluminium pigments which are at least partially coated with lubricant. The aluminium pigments have a relative width of the thickness distribution Δh - determined by thickness counting using scanning electron microscopy - calculated on the basis of the corresponding cumulative curve of the relative frequencies according to formula Δh = 100*(h90 - h10)/h50, of between 30% and less than 70 %, and an X-ray diffractogram which has been measured on pigments in an essentially plane-parallel arrangement, with one or two main peaks which do not correspond to the [111]-reflexes. The invention also relates to a method for producing the aluminium pigments and to the uses thereof, and to nail varnishes and printing inks containing the aluminium pigments according to the invention.

A process for the production of substituted carboxylic acids

Alkenyl-substituted carboxylic acids are prepared by reacting a mono-olefine with a compound having a double bond between two carbon atoms conjugated with one or more carbonyloxy groups (i.e. an a , b -unsaturated carboxylic acid or an anhydride or ester thereof) to obtain an alkenyl-substituted carboxylic acid, anhydride or ester; reacting this with an aqueous solution of an inorganic base, separating the aqueous layer containing the salt of the substituted carboxylic acid, acidifying in the presence of a water-insoluble organic solvent (which may be added with or immediately after the acid), and recovering the substituted acid from the solvent layer, e.g. by removal of the solvent. Specified olefines are ethylene, propylene, butylene-1, amylene-1, hexylene-1, octene-1, decene-1, dodecene-1, tetradecene-1, octadecene-1, cosene-1 tetracosene-1, hexacosene-1, the corresponding internally unsaturated olefines, styrene, methyl styrene, and mixtures of olefines, e.g. C14-18 and C18-24 olefine mixtures. Specified unsaturated carbonyloxy compounds are acrylic, crotonic, 1-methylacrylic, angelic, tiglic, 2-hexenoic, 2-heptenoic and other 2-ethylenically unsaturated aliphatic acids and the corresponding esters; maleic, fumaric, ethylidene malonic, propylidene malonic, isopropylidene malonic and butylidene malonic acids and their esters and anhydrides, especially maleic anhydride; cinnamic acid, 4-phenylbut-2-enoic acid, and aralkyl unsaturated dibasic carboxylic acids and their esters and anhydrides. The addition reaction is preferably conducted at at least 100 DEG C. Specified inorganic bases are alkali metal hydroxides. Specified water-insoluble organic solvents are benzene, toluene, isopropyl ether and halogenated hydrocarbons; preferably 20-40% by volume is used, based on the volume of the organic acid salt solution. Suitable acids for acidification are HCl, H2SO4 and HNO3. Examples react maleic anhydride with C18-24 cracked wax olefines. The products of the process are ...

A method of manufacturing a starting device for a three-phase electric motor, and a starting device

When manufacturing a starting device for a three-phase electric motor, especially a soft starter, in at least one embodiment an arc quenching system is at least partly removed from a commercially available contactor that so becomes to a modified contactor. In at least one embodiment, a modified contactor is used as a contactor in the starting device.

ISOLATED EXHAUST MANIFOLD BY AN AIR SLOT FOR AN INTERNAL COMBUSTION ENGINE

ISOLATED EXHAUST MANIFOLD BY AN AIR SLOT FOR AN INTERNAL COMBUSTION ENGINE

Oprf/i agents and their use in hospitalized and other patients

The present invention relates to a new use of a vaccine comprising a fusion protein that comprises the Pseudomonas aeruginosa outer membrane protein I (OprI or OMPI) which is fused with its amino terminal end to the carboxy-terminal end of a carboxy-terminal portion of the Pseudomonas aeruginosa outer membrane protein F (OprF or OMPF), as well as to a new use of a monoclonal or polyclonal antibody against this fusion protein or a pharmaceutical composition thereof.

Vacuum contactor with movable guide element

A vacuum contactor includes a stationary contact and a moving contact, which can be moved in order to produce a current-carrying connection. In order to guide the moving contact during its movement in the enclosure, at least one guide element, which can be moved in a groove, is provided on the moving contact.

Military motor vehicle for team transport

Ein militärisches Kraftfahrzeug zum Mannschaftstransport mit einem Fahrgestell (1), auf dem hintereinander eine Fahrkabine (2) und ein nach oben offener, mit einer Plane abdeckbarer Transportaufbau (3) zur Aufnahme einer Mannschaft angeordnet sind. An der Oberseite des Transportaufbaus (3) ist eine Überroll-Schutzeinrichtung angeordnet mit zwei jeweils über einer Seitenwand des Transportaufbaus (3) angeordneten, sich in Längsrichtung erstreckenden Überrollbügeln (8.1), wobei die Enden jedes Überrollbügels (8.1) lösbar mit dem Transportaufbau (3) verriegelt sind und die beiden Überrollbügel durch quer zur Längsrichtung verlaufende Versteifungselemente miteinander verbunden sind. Von den Versteifungselementen kann mindestens eines als fest mit den Überrollbügeln verbundene Querstrebe ausgebildet sein. Ein weiteres Versteifungselement kann als über Drehgelenke (10.1) mit den Überrollbügeln (8.1) verbundene Querstrebe ausgebildet sein, das fest mit Schwingen (11.1) verbunden ist, welche um horizontal angeordnete Schwenkachsen (12) schwenkbar sind. Die Schwingen können in Rückenlehnen der Sitze oder Sitzbänke (6, 7) integriert sein. Nach Lösen von Verriegelungsvorrichtungen (8.11, 8.12) können die Überrollbügel (8.1) durch Nachhintenschwenken abgesenkt werden, so dass sich die Gesamthöhe des Kraftfahrzeugs verringert und somit die Verladung in einen Hubschrauber ermöglicht wird. A military motor vehicle for team transport with a chassis (1) on which a driving cabin (2) and a transport structure (3) which is open at the top and can be covered with a tarpaulin are arranged one behind the other to accommodate a team. On the top of the transport structure (3) there is a rollover protection device with two roll bars (8.1), each extending over a side wall of the transport structure (3) and extending in the longitudinal direction, the ends of each roll bar (8.1) being detachably attached to the transport structure (3 ) are locked and the two roll bars are connected to each ...

Lubrication

Low application torque, tamper evident plastic closure and container system with enhanced visual tamper evidency

A container for use with a closure is provided, and includes a receptacle, a neck extending therefrom, a closure-engaging thread segment arranged on the neck of the container to engage the closure thread segment arranged on the closure, and a plurality of spaced apart protrusions protruding radially toward the closure from the neck of the container, the plurality of spaced apart protrusions forming a protrusion pattern that has a composite orientation that is helically opposite that of the closure-engaging thread segment to engage and to separate the frangible tamper-evident band portion from the closure when the closure is rotated off of the neck. With this structure, the closure and container system provides an improved anti-backoff, tamper evident closure and container system that reduces torque used to initially apply the closure to the container and improves reliably by reducing stress on the component parts, while desirably preventing backoff from occurring.

Computerized device and method for processing image data

A computerized device (100) for processing image data (OCT, RID) is proposed. The computerized device (100) comprises a receiving unit (110) which is configured to receive optical coherence tomography data (OCT) of a of a tissue, in particular of a retina, a providing unit (120) which is configured to provide a convolutional neural network (CNN) for processing the optical coherence tomography data (OCT), and a processing unit (130) which is configured to process the received optical coherence tomography data (OCT) using the convolutional neural network (CNN) for identifying at least one certain object (IRC, SRF) in the tissue.

Switching device with integrated main current path tap

Vacuum contactor with sliding guide element

Device for locating and distinguishing objects at sensor areas

Vorrichtung zum Erfassen von Eigenschaften wenigstens eines Objekts wobei durch erste Elektrodenmittel (1) wenigstens ein Sensorgebiet (27) aufgespannt ist, durch wenigstens zwei zweite Elektrodenmittel (2,3,21,22) wenigstens zwei Aufenthaltsgebiete (5,6) aufgespannt sind, Messeinrichtung (32) für Impedanzen zwischen Elektrodenmitteln (1,2,3,21,22) (und Masse) sowie eine Auswerteeinheit (12), die dazu eingerichtet ist, anhand der Impedanzmesswerte Eigenschaften von Objekten (8) zu erfassen, enthalten sind. Beispielhafte Anwendungen stellen Sportarten dar, in denen die Aufenthaltsgebiete (5,6) Spielfeldhälften, Objekte (8) Spieler und das Sensorgebiete (27) die Grenzfläche zwischen den beiden Spielfeldhälften darstellen. Device for detecting properties of at least one object wherein at least one sensor region (27) is spanned by first electrode means (1), at least two residence regions (5, 6) are spanned by at least two second electrode means (2, 3, 21, 22), measuring device (32) for impedances between electrode means (1,2,3,21,22) (and ground) as well as an evaluation unit (12) which is adapted to detect properties of objects (8) on the basis of the impedance measured values. Exemplary applications are sports in which the location areas (5, 6), game field halves, objects (8) players, and the sensor areas (27) represent the interface between the two game field halves.

Method for operating at least two laser devices, and display device

The invention relates to a method for operating at least two laser devices, in particular for producing a display, in which the at least two laser devices produce a sequence of light spots, in particular of different brightness. In a first step, a first of the sequence of light spots is produced by at least one of the at least two laser devices during a first period of time, and a voltage drop across the at least one of the at least two laser devices is registered within the first period of time. Then, a target brightness for a second of the sequence of light spots is determined for at least one of the at least two laser devices. Subsequently, a supply current and/or an activation time are/is determined during a second period of time for producing the target brightness for the at least one of the at least two laser devices, with the voltage drop registered within the first period of time being taken into account, and are/is used to control at least one of the at least two laser devices during the second period of time.

Brake-valve device

Tracked vehicle with a drive unit

The invention relates to a tracked vehicle (10) comprising tracks (38) which are driven, a drive unit (28, 28) for each driven track (38), containing a drive wheel (52) which engages in said track (38), an electric motor (18, 20), a drive train (30, 32) which is connected before the drive wheel (52), and a shaft (34, 36) which driveably interconnects the electric motor (18, 20) and the drive train (30, 32). The inventive tracked vehicle also comprises a vehicle pan (12) which supports each drive unit (26, 28) on a wall (40, 42). The invention is characterized in that vibration damping means (44) are interconnected between the wall (40, 42) and the drive unit (26, 28) so that the drive unit (26, 28) is vibrationally isolated from the wall (40, 42) of the vehicle pan (12).

Armor component for a vehicle

Panzerungsbauteil für ein Fahrzeug, welches Wandbereiche (7, 8) unterschiedlicher Wandstärke und einen dreidimensionalen Formverlauf aufweist, dadurch gekennzeichnet, dass das Panzerungsbauteil als einteiliges Gussbauteil und als Stirnwand (1) ausgebildet ist, wobei die Stirnwand (1) eine Mehrzahl von Durchbrüchen (6) für jeweilige Funktionsbauteile aufweist, wobei im Bereich dieser Durchbrüche (6) dreidimensionale Formverläufe der Stirnwand (1) vorliegen, die von einem ebenen Verlauf abweichen. Armor component for a vehicle, which has wall regions (7, 8) of different wall thicknesses and a three-dimensional shape, characterized in that the armor component is designed as a one-piece cast component and as an end wall (1), the end wall (1) having a plurality of openings (6 ) for respective functional components, wherein in the region of these openings (6) there are three-dimensional shapes of the end wall (1) that deviate from a flat shape.

Turbocharger rotor

Die vorliegende Erfindung betrifft einen Rotor (1) für eine Ladeeinrichtung, insbesondere für einen Abgasturbolader, mit einer ein Turbinenrad (2) und ein Verdichterrad tragenden Welle (3). Erfindungswesentlich ist dabei, dass zur Anbindung insbesondere des Turbinenrades (2) an die Welle (3) zumindest zwischen diesem und der Welle (3) wenigstens ein poröses metallisches oder keramisches Zwischenstück (4) vorgesehen ist, das über einen Infiltrationsprozess mit dem Turbinenrad (2) und/oder der Welle (3) verbunden ist.

Chain track

A chain link of a chain track is penetrated at its joints to adjacent chain links by bolts, for example connector bolts or hinge bolts. The chain links are connected in a positive and frictional manner. The chain link may be made of elastomeric material in which flexible, high tensile filaments are embedded. The filaments may be wound back and forth between the two joining locations and loop around the cross-sectional surfaces of the bolts (connector bolts or hinge bolts) located at the joining locations, in alternating directions. A chain track assembled from individual chain link elements may have individual chain link elements including a shear field support of one or more layers of readily bending steel foil, surrounded on both sides by elastomeric material. The layer or layers of steel foils are clamped at the two joint locations of adjacent chain link elements between a transverse web and a clamping bar, with the chain links connected to one another by threaded fasteners. The shear field support is tensioned between the transverse web and the clamping bar and a space filled with an elastomeric material is provided between the side which faces away from the transverse web of the clamping bar and the shear field support for achieving a greater loading and a longer serviceable life of the endless chain track.

Anti-backoff, low application torque, tamper evident plastic closure and container system with enhanced visual tamper evidency

A container (320,500,600,800) for use with a closure (320,310) is provided, and includes a receptacle, a neck (340,510,610) extending therefrom, a closure-engaging thread segment (350,520,620,820) arranged on the neck of the container to engage the closure thread segment (400) arranged on the closure, and a plurality of spaced apart protrusions (360,530,630,830) protruding radially toward the closure from the neck of the container, the plurality of spaced apart protrusions forming a protrusion pattern that has a composite orientation (370,550,650,850) that is helically opposite that of the closure-engaging thread segment to engage and to separate the frangible tamper-evident band portion (380) from the closure when the closure is rotated off of the neck. With this structure, the closure and container system provides an improved anti-backoff, tamper evident closure and container system that reduces torque used to initially apply the closure to the container and improves reliably by reducing stress on the component parts, while desirably preventing backoff from occurring.

Keyboard to tape data input preparation unit

A data input preparation machine having keyboard means for use in entering data into buffer storage and processing such data to and from magnetic tape. The buffer storage includes a plurality of positions, each of which positions has storage means for both program and data information. Automatic verification means provide automatic verification of program entries at machine speeds, and memory and field backspace keys permit automatic backspacing to the previously keyed character of the most significant position of a field. The most significant position entries in the program section of buffer storage are also used for the LOF sequences for individual characters in such field, the transport being from the more significant positions of the field to the less significant positions of the field. Alphanumeric display means provide display of characters in a pattern identical to the character pattern on the keyboard; individual members for identifying the selected positions in memory, and alphanumeric program field identifiers all of which materially reduce operator time in the data processing operation. Novel register and memory arrangements using a reduced amount of equipment minimize the cycle process time for both program and data entry.

Method for reconstituting a recombinant protein to its biologically active form

In a method for reconstituting a recombinant protein from a denatured state to its active form, a feed solution containing the recombinant protein in its denatured and/or in biologically inactive intermediate forms is subjected to a chromatographic separation process, in which the protein is reconstituted under conditions that promote refolding of the protein and the intermediate forms are separated from the refolded protein. The denatured form and/or the inactive intermediate forms of the protein are separated from the refolded protein in a continuous or quasi-continuous manner and optionally recycled to the feed solution.

Lightweight valve

A lightweight valve ( 1 ) for internal combustion engines is provided, which comprises a valve stem ( 3 ), a hollow valve cone ( 7 ) and a valve disk ( 9 ) closing the valve cone ( 7 ). In this connection, the valve stem ( 3 ) is provided with a hollow space ( 5 ) at its end facing the valve disk ( 9 ). The lightweight valve ( 1 ) is characterized by at least one force transmission element ( 19 ) which is provided on the valve disk ( 9 ) and extends through the hollow valve cone ( 7 ) into the stem hollow space ( 5 ).

Computerized device and method for processing image data

A computerized device (100) for processing image data (OCT, RID) is proposed. The computerized device (100) comprises a receiving unit (110) which is configured to receive optical coherence tomography data (OCT) of a of a tissue, in particular of a retina, a providing unit (120) which is configured to provide a convolutional neural network (CNN) for processing the optical coherence tomography data (OCT), and a processing unit (130) which is configured to process the received optical coherence tomography data (OCT) using the convolutional neural network (CNN) for identifying at least one certain object (IRC, SRF) in the tissue.

Chain track

ABSTRACT OF THE DISCLOSURE A chain track assembled from individual chain link elements with individual-chain link elements made up of a shear field support of one or more layers of readily bending steel foil, surrounded on both sides by an elastomeric material. The layer or layers, respectively, of steel foils are clamped at the two joint locations of adjacent chain link elements, between a transverse web and a clamping bar, with the chain links connected to one another by threaded fasteners. The shear field support is tensioned between the transverse web and the clamping bar and a space filled with an elastomeric material is provided between the side which faces away from the transverse web of the clamping bar and the shear field support for achieving a greater loading and a longer serviceable life of the endless chain track.

Armored infantry fighting vehicle

Vehículo blindado de combate de infantería con un casco (1) portado por un mecanismo de rodadura de cadenas (2) y una estación de armas (3-4) dispuesta sobre el techo del casco del vehículo, estando el recinto interior del casco (1) del vehículo dividido en tres zonas, a saber, una zona delantera (1.1) en la que están ubicados el dispositivo de accionamiento (5) y el puesto de conductor (6), una zona trasera (1.2) en la que están ubicados los puestos (7) para la tripulación, y una zona central (1.3) que, según el equipamiento del vehículo, puede ser utilizada para fines variables, especialmente para alojar una plataforma de torreta (3.1) y/o al menos un puesto (8.1, 8.2, 8.11, 8.12) para sirvientes de la estación de armas y/o un recinto de estiba para munición y dispositivos (10.1, 10.2, 10.3) de alimentación de munición, caracterizado porque el vehículo general está constituido por módulos individuales, a saber, un módulo de base que contiene el casco (1) del vehículo, un módulo de mecanismo de rodadura de cadenas (2) y otros módulos (3, 3', 3'', 9.1-9.6) que hacen posible la construcción de variantes de equipamiento diferentes con un peso diferente, sobre y/o en el mismo casco (1) del vehículo pueden fijarse módulos de protección diferentes (9.1-9.5) del blindaje y el módulo de mecanismo de rodadura de cadenas (2) puede fijarse al casco (1) del vehículo en forma desacoplable y puede fijarse al módulo de mecanismo de rodadura de cadenas un módulo (9.3) de protección contra minas. Armored infantry fighting vehicle with a helmet (1) carried by a chain rolling mechanism (2) and a weapons station (3-4) arranged on the roof of the vehicle's hull, the interior of the helmet being (1) ) of the vehicle divided into three zones, namely a front zone (1.1) in which the drive device (5) and the driver's position (6) are located, a rear zone (1.2) in which the positions (7) for the crew, and a central area (1.3) which, depending on the equipment of the ...

Procedure for checking the functioning of unmanned armed missiles

Verfahren zur Überprüfung der Funktionsfähigkeit von unbemannten, bewaffneten Flugkörpern mittels einer Missionssimulation, – wobei der Flugkörper (1) eine Vielzahl von elektronischen Komponenten aufweist, – wobei der Flugkörper (1) Kommunikationsschnittstellen (16', 18) zur Kommunikation von zumindest einem Teil der Komponenten mit außerhalb des Flugkörpers vorgesehenen Einrichtungen aufweist, – wobei zumindest einige der Komponenten Sensoren und/oder Aktuatoren aufweisen, – wobei der Flugkörper während der Überprüfung von außen mit Energie, Daten und Kühlmittel versorgt wird, – wobei die Überprüfung zumindest – die Funktionsfähigkeit der Sensoren und Aktuatoren des Flugkörpers und – die Kommunikation des Flugkörpers (1) über seine Kommunikationsschnittstellen (16', 18) umfasst, – dass während der Überprüfung festgestellte Fehler kategorisiert werden in: – sporadisch auftretende Fehler, – nicht-fatale Fehler und – fatale Fehler, – wobei beim Auftreten eines fatalen Fehlers einer Komponente ein Abbruch der Überprüfung erfolgt und eine Fehlermeldung sowie... Method for checking the functioning of unmanned, armed missiles by means of a mission simulation, - wherein the missile (1) has a plurality of electronic components, Wherein the missile (1) has communication interfaces (16 ', 18) for communicating at least a part of the components with devices provided outside the missile, Wherein at least some of the components comprise sensors and / or actuators, - the missile is supplied with energy, data and coolant during the external inspection, - the review at least - The functionality of the sensors and actuators of the missile and Comprising the communication of the missile (1) via its communication interfaces (16 ', 18), - that errors found during the verification are categorized in: - sporadic errors, - non-fatal errors and - fatal mistakes, - If a fatal error of a component occurs, the check is aborted and an error message appears and ...

Oprf/i agents and their use in hospitalized and other patients

The present invention relates to a new use of a vaccine comprising a fusion protein that comprises the Pseudomonas aeruginosa outer membrane protein I (OprI or OMPI) which is fused with its amino terminal end to the carboxy-terminal end of a carboxy-terminal portion of the Pseudomonas aeruginosa outer membrane protein F (OprF or OMPF), as well as to a new use of a monoclonal or polyclonal antibody against this fusion protein or a pharmaceutical composition thereof.

Exhaust gas turbocharger for an internal combustion engine

Die Erfindung betrifft einen Abgasturbolader für einen Verbrennungsmotor. Aufgabe der Erfindung ist es, einen Abgasturbolader zu entwickeln, der kostengünstig aufgebaut ist und der eine verbesserte Funktionalität zeigt. Die Erfindung besteht darin, dass bei einem Abgasturbolader für einen Verbrennungsmotor, mit einem im Abgasstrom des Motors angeordneten Turbinenrad aus einer warmfesten Leichtmetalllegierung, mit einem im Ansaugluftstrom des Motors angeordneten Verdichterrad, mit einer Welle aus Stahl, wobei das Verdichterrad auf der Welle sitzt und das Turbinenrad durch Schweißen mit der Welle verbunden ist, und mit einer Lagerung für die Welle, am Turbinenrad (1) eine dem Wellendurchmesser (5) angepasste Nabe (4) ausgebildet ist, wobei die Verbindungsstelle (3) zwischen der Nabe (4) des Turbinenrades (1) und der Welle (2) in der Umgebung der Lagerung (6, 7, 14, 15) angeordnet ist. The invention relates to an exhaust gas turbocharger for an internal combustion engine. The object of the invention is to develop an exhaust gas turbocharger, which is constructed inexpensively and which shows improved functionality. The invention consists in that, in an exhaust gas turbocharger for an internal combustion engine, with a arranged in the exhaust stream of the engine turbine made of a heat-resistant alloy, with a arranged in the intake air flow of the engine compressor, with a shaft made of steel, wherein the compressor sits on the shaft and the Turbine is connected by welding to the shaft, and with a bearing for the shaft on the turbine wheel (1) a shaft diameter (5) adapted hub (4) is formed, wherein the connection point (3) between the hub (4) of the turbine wheel (1) and the shaft (2) in the vicinity of the storage (6, 7, 14, 15) is arranged.

Aluminium compounds for use in therapeutics and vaccines

The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein. The invention further relates to aqueous compositions comprising a protein and an aluminium-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.

Virus purification

Described herein are processes for purifying infectious virus particles and uses of protamine in such processes.

Method for reconstituting a recombinant protein to its biologically active form

In a method for reconstituting a recombinant protein from a denatured state to its active form, a feed solution containing the recombinant protein in its denatured and/or biologically inactive intermediate forms is subjected to a chromatographic separation process, in which the protein is reconstituted under conditions that promote refolding of the protein and the intermediate forms are separated from the refolded protein. The denatured form and/or the inactive intermediate forms of the protein are separated from the refolded protein in a continuous or quasi-continuous manner and optionally recycled to the feed solution.

Aluminium shot for thin, plate-shaped effect pigments, method for the production thereof, and use of same

The invention relates to an aluminium shot for thin, plate-shaped effect pigments with a narrow relative width of the thickness distribution. The shot according to the invention is characterised by a grain bond of d10 = between 0.15 and 3.0 μm and d50 = between 0.8 and 5.0 μm and d90 = between 2.0 and 8.0 μm. The invention also relates to a method for producing the aluminium shot according to the invention, and to the use of the aluminium shot according to the invention as a laser marking means or a laser weldability means for plastic materials. The invention further relates to the use of the aluminium fine shot for producing ultra-thin aluminium pigments by means of wet grinding.