Detecting bcl-b expression in cancer and uses thereof

Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast cancer, prostate cancer, lung cancer, or gastric cancer.

Methods and Compounds Useful to Induce Apoptosis in Cancer Cells

The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.

Method for measuring luminescence at a luminescence detection workstation

A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents. Preferred embodiments of processing software integrated with the invention include elements for mechanical alignment, outlier shaving, edge detection and masking, manipulation of multiple integration times to expand the dynamic range, crosstalk correction, dark subtraction interpolation and drift correction, multi-component analysis applications specifically tailored for luminescence, and uniformity correction.

Tandem blade rotor disk

A tandem rotor disk apparatus may include a rotor disk body concentric about an axis. The tandem rotor disk apparatus may also include a first blade extending radially outward of the rotor disk body and a second blade extending radially outward of the rotor disk body. The first blade may be offset from the second blade in a direction parallel to the axis. The tandem rotor disk apparatus may be implemented in a gas turbine engine with no intervening stator vane stages disposed between the first blade and the second blade. The tandem rotor disk apparatus may include two separate rotor disk bodies.

Orthodontic Lip Advancer

A lip advancer is presented for preventing proclining or tipping forward of the lower incisors that causes relapse and gingival recession in retention with forward intermaxillary elastic traction that extends diagonally from posterior bracket hooks in the lower arch anchored to hooks on upper anchorage appliances. In one embodiment, the lip advancer is comprised of an invisible clear liner type plastic retainer for use with a dental arch, and a bumper extending labially from the retainer for pressing against the patient's lip causing the lip muscles to react pushing back with an opposite force thus preventing the anterior teeth from flaring labially. In another embodiment, for use with a plurality of brackets and an archwire, the lip advancer comprises an auxiliary archwire extending from and in contact with the brackets, and a bumper formed on the auxiliary archwire for applying pressure labially to a corresponding lip. 1. An orthodontic lip advancer for use with an orthodontic upper anchoring appliance having a first hook for attaching an inter-arch traction elastic thereon , the traction elastic extending diagonally to attach to at least one lower posterior orthodontic bracket having a second hook , wherein the traction elastic imparts a distal-to-mesial force on the lower arch causing labial flaring of the lower arch anterior teeth , the orthodontic lip advancer comprising:a liner-type plastic retainer sized and shaped for use with a lower dental arch; anda bumper extending labially from the retainer at an anterior portion thereof and having a thickness for pressing against the patient's lip thus stretching the lip labially causing the lip muscles to react pushing back with a lingual second force opposite the first force thus substantially preventing the anterior teeth from flaring labially.2. The orthodontic lip advancer of claim 1 , wherein the bumper comprises a plurality of portions each corresponding to an anterior tooth portion of the retainer.3. The ...

Microcurrent-stimulation-therapy apparatus and method

A system and method for applying stimulation therapy to a patient, the system including a first stimulation strip that includes a first elongated portion configured to be placed on the upper eyelid of the first eye of the patient and a second elongated portion configured to be placed on the lower eyelid of the first eye of the patient, wherein the first stimulation strip includes: a first plurality of individually controlled electrodes configured to deliver a microcurrent stimulation therapy to the patient, a first plurality of individually controlled light emitters configured to deliver light stimulation therapy to the patient, and a first plurality of individually controlled heat sources configured to deliver heat therapy to the patient; and a controller operatively coupled to the first stimulation strip and configured to control delivery of the microcurrent stimulation therapy, the light stimulation therapy, and the heat therapy.

Techniques for location-based alert of available applications

In one aspect, a first device includes at least one processor and storage accessible to the at least one processor. The storage may include instructions executable by the at least one processor to identify a location of a user device, access a data structure correlating locations to applications, identify at least a first application in the data structure using the location of the user device, and generate a message presentable on the user device alerting the user of the availability of the first application.

Displaying a user input modality

An aspect provides a method, including: determining, using at least one detector, a location of a hand of a user with respect to an information handling device; receiving, from at least one sensor, gaze tracking data associated with an eye of a user; determining, using a processor and based upon the gaze tracking data, a location within an application currently active on the information handling device of a gaze of the user; identifying, using a processor, a character type associated with the application and corresponding to the determined location; identifying a keyboard having a keyboard layout corresponding to the character type, wherein the identifying a keyboard includes identifying a keyboard layout allowing provision of the identified character type; and displaying, on a display device of the information handling device, at a location corresponding to the location of the hand of the user, the keyboard having the keyboard layout.

Removing colloidal cobalt from an aqueous composition

A method of removing colloidal cobalt from an aqueous composition comprising bringing the aqueous composition into contact with a vinyl aromatic resin, wherein the vinyl aromatic resin comprises benzyl alcohol groups, benzyl ether groups, and methylene bridge groups, wherein the vinyl aromatic resin has a chlorine content, by weight based on the weight of resin, of 10,000 ppm or less.

Static guide vane with internal hollow channels

A static guide vane for use in a fan section of a gas turbine engine includes an outer platform and an inner platform. The inner and outer platforms are connected by an airfoil. The airfoil have channels extending into a main body of the airfoil to reduce the weight of the vane. A cover closes off the channels with the cover providing a portion of the airfoil.

Thermally isolated rotor systems and methods

A rotor assembly of a gas-turbine engine may comprise a first rotor blade, a second rotor blade, a third rotor blade, a first platform sealing assembly and a second platform sealing assembly. The first platform sealing assembly may be disposed between a first platform of the first rotor blade and a second platform of the second rotor blade. The second platform sealing assembly may be disposed between the second platform and a third platform of the third rotor blade.

Catalysts for Low Temperature Oxidation

The invention provides a composite catalyst containing a first component and a second component. The first component contains nanosized gold particles. The second component contains nanosized platinum group metals. The composite catalyst is useful for catalyzing the oxidation of carbon monoxide, hydrocarbons, oxides of nitrogen, and other pollutants at low temperatures.

Upper bifi frame for a gas turbine engine and methods therefor

An upper bifi frame for preventing air leakage in a gas turbine engine including an engine casing and a fan case is provided. The upper bifi frame includes a forward fairing having a forward fairing midsection extending between the engine casing and the fan case. The forward fairing has a forward fairing first end including a flange configured to couple to the engine casing. The forward fairing has a forward fairing second end extending from the forward fairing midsection and configured to couple to the fan case. At least one aft seal is secured to the forward fairing and forms a seal therewith.

Treating vinyl aromatic resin

Provided is a method of treating a vinyl aromatic resin (I) comprising (a) bringing the vinyl aromatic resin (I) into contact with an alcohol, and maintaining the contact between the vinyl aromatic resin (I) and the alcohol for 10 minutes or more, and (b) bringing the vinyl aromatic resin into contact with a base. wherein the vinyl aromatic resin (I), prior to steps (a) and (b), has benzyl chloride groups, benzyl alcohol groups, and methylene bridge groups.

Overhead Door Storage System

One embodiment of the overhead storage system uses the tube of a conventional overhead door hinge to releasably attach a rack with conventional ways to hold storage items. Another embodiment of an overhead door storage system uses the conventional hardware of a conventional overhead door to mount a rack with hooks to hold garage storage items on an overhead door. Another embodiment of the overhead storage system uses a bracket to mount a rack with hooks to hold garage storage items using the conventional hardware of a conventional overhead door. Other embodiments are described and shown.

Elastomeric epoxy resin

Phosphoanhydrite process

ELECTRONIC MICROSCOPE AND SPECTROSCOPIC SYSTEM

Process for producing cross-linked monodispersed polymeric particles

Spherical monodispersed polymeric particles are prepared from vinyl monomers and crosslinking polymerizable polyvinyl monomers. More particularly, a novel process for producing spherical monodispersed gel particles that are about 1-6 mu m in size and contain at least about 0.5 to about 3 weight percent (based on polymerizable vinyl monomer/vinyl polymer) of a polymerizable polyvinyl monomer is disclosed. The process comprises the steps of combining an isoalkanol solvent, a polymerizable vinyl monomer and a crosslinking polymerizable polyvinyl monomer under timed and monitored conditions.

Methods of using chemiluminescent 1,2-dioxetanes

Processes are disclosed in which light of different wavelengths is simultaneously released from two or more enzymatically decomposable chemiluminescent 1,2-dioxetane compounds, said compounds being configured, by means of the inclusion of a different light emitting fluorophore in each of them, to each emit light of said different wavelengths, by decomposing each of said compounds by means of a different enzyme. Such processes can be used in multi-channel assays--immunoassays, chemical assays and nucleic acid probe assays--to detect the presence or determine the concentration of chemical or biological substances, and in multi-channel chemical/physical probe procedures for studying the microstructures of macromolecules.

Conversion of fluoroanhydrite to plaster

CONVERSION OF FLUOROANHYDRITE TO PLASTER Abstract of the Disclosure Gypsum plaster and gypsum wallboard products can be made from fluoroanhydrite by contacting the fluoroanhydrite with a reactive silica selected from the group consisting essen-tially of Portland cement; perlite; calcium, sodium or potas-sium silicates; pyrogenic colloidal silica and diatomaceous earth; and after gradual conversion of the fluoroanhydrite to substantially pure fluorogypsum, the purified gypsum is pro-cessed in customary fashion in the industrial manufacture of plaster products. The reactive silica may be added to the fluoroanhydrite during the gradual aging conversion in water to fluorogypsum; or it may be added during water calcination of the fluorogypsum to stucco; or to the gauging water during gypsum plaster or wallboard product formation from the fluorostucco.

Monocular portable communication and display system

A monocular head mounted display system in which a matrix display element is mounted within a housing that is positioned relative to one eye of the user to display information. The display is connected to a video or information source such that the user can view information or images shown on the display. The display can be mounted to a frame so that the user can move the display in and out of the user's filed of view without adjusting the supporting harness that holds the display on the user's head.

Process for treating biomass to derivatize polysaccharides contained therein to increase their accessibility to hydrolysis and subsequent fermentation

A process is described for producing fermentable sugars derivable from biomass that contains polysaccharide, such as cellulose, made increasingly accessible as a substrate for enzymatic degradation or other methods of depolymerization. These fermentable sugars are subsequently able to be fermented to produce various target chemicals, such as alcohols, aldehydes, ketones or acids.

Process for treating biomass to increase accessibility of polysaccharides contained therein to hydrolysis and subsequent fermentation, and polysaccharides with increased accessibility

In this invention, a process for producing fermentable sugars derivable from biomass that contains polysaccharide, such as cellulose, which has been made increasingly accessible as a substrate for enzymatic degradation or other methods of depolymerization. The process of the present invention increases accessibility of polysaccharides, typically present in biomass and produces polysaccharides with increased accessibility. The polysaccharides with increased accessibility may be subsequently saccharified to yield fermentable sugars. These fermentable sugars are subsequently able to be fermented to produce various target chemicals, such as alcohols, aldehydes, ketones or acids.

Process for treating biomass to derivatize polysaccharides contained therein to increase their accessibility to hydrolysis and subsequent fermentation

A process is described for producing fermentable sugars derivable from biomass that contains polysaccharide, such as cellulose, made increasingly accessible as a substrate for enzymatic degradation or other methods of depolymerization. These fermentable sugars are subsequently able to be fermented to produce various target chemicals, such as alcohols, aldehydes, ketones or acids.

Process for treating biomass to increase accessibility of polysaccarides contained therein to hydrolysis and subsequent fermentation, and polysaccharides with increased accessibility

In this invention, a process for producing fermentable sugars derivable from biomass that contains polysaccharide, such as cellulose, which has been made increasingly accessible as a substrate for enzymatic degradation or other methods of depolymerization. The process of the present invention increases accessibility of polysaccharides, typically present in biomass and produces polysaccharides with increased accessibility. The polysaccharides with increased accessibility may be subsequently saccharified to yield fermentable sugars. These fermentable sugars are subsequently able to be fermented to produce various target chemicals, such as alcohols, aldehydes, ketones or acids.

Process for increasing the dry strength of paper

Addition of a premixed aqueous mixture of anionic dry strength resin and cationic or amphoteric starch to a paper making pulp slurry yields paper with higher dry strength than paper that is the same except that the starch and dry strength resin are added separately.

Pyridine and pyrimidine carboxylate herbicides and methods of use thereof

Ink jet break-off length measurement apparatus and method

A jet break-off length measurement apparatus for a continuous liquid drop emission system is provided. The jet break-off length measurement apparatus comprises a liquid drop emitter containing a positively pressurized liquid in flow communication with at least one nozzle for emitting a continuous stream of liquid. Heater resistor apparatus is adapted to transfer pulses of thermal energy to the liquid in flow communication with the at least one nozzle sufficient to cause the break-off of the at least one continuous stream of liquid into a stream of drops of predetermined volumes. A sensing apparatus adapted to detect the stream of drops of predetermined volumes is provided. A control apparatus is adapted to determine a characteristic of the stream of drops of predetermined volumes that is related to the break-off length. Further apparatus is adapted to inductively charge at least one drop and to cause electric field deflection of charged drops. Jet stimulation apparatus comprising a plurality of transducers corresponding to the plurality of nozzles and adapted to transfer pulses of energy to the liquid sufficient to cause the break-off of the plurality of continuous streams of liquid into a plurality of streams of drops of predetermined volumes is also disclosed. Methods of measuring the jet break-off length using phase sensitive amplification circuitry are disclosed.

Continuous printhead contoured gas flow device

A continuous liquid printing system gas flow device includes a gas flow duct structure including a first wall and a second wall. The first wall and the second wall are positioned spaced apart and opposite each other to form an opening. The first wall is contoured such that a distance between the first wall and the second wall varies when viewed in a direction perpendicular to the opening.

Printhead including port after filter

A printhead includes a liquid source, a first substrate, a filter, and a liquid chamber. Portions of the first substrate define a nozzle adapted to emit liquid from the liquid source. The liquid chamber includes a port. The liquid chamber is in fluid communication with the nozzle and the filter and is positioned between the first substrate and the filter.

Printhead including reinforced liquid chamber

A printhead includes a liquid manifold. A filter is in fluid communication with the liquid manifold. A nozzle plate includes a length and an array of nozzles extending along the length of the nozzle plate. A liquid chamber is positioned between the nozzle plate and the filter. The liquid chamber is in fluid communication with the array of nozzles and the filter and includes a width that is substantially perpendicular to the length of the nozzle plate. The liquid chamber includes a structure that is spaced apart from the nozzle plate and spaced apart from the filter. The structure spans the width of the liquid chamber. A liquid source provides a liquid through the manifold, the filter, the liquid chamber under pressure sufficient to jet individual streams of the liquid from the array of nozzles.

Liquid chamber reinforcement in contact with filter

A printhead includes a liquid manifold. A filter is in fluid communication with the liquid manifold. A nozzle plate includes a length and an array of nozzles extending along the length of the nozzle plate. A liquid chamber is positioned between the nozzle plate and the filter. The liquid chamber is in fluid communication with the array of nozzles and the filter and includes a width that is substantially perpendicular to the length of the nozzle plate. The liquid chamber includes a structure that is spaced apart from the nozzle plate and in contact with the filter. The structure spans the width of the liquid chamber and includes a plurality of flow through channels. A liquid source provides a liquid through the manifold, the filter, the liquid chamber under pressure sufficient to jet individual streams of the liquid from the array of nozzles.

Ink jet break-off length measurement apparatus and method

A jet break-off length measurement apparatus for a continuous liquid drop emission system is provided. The jet break-off length measurement apparatus comprises a liquid drop emitter containing a positively pressurized liquid in flow communication with at least one nozzle for emitting a continuous stream of liquid. Heater resistor apparatus is adapted to transfer pulses of thermal energy to the liquid in flow communication with the at least one nozzle sufficient to cause the break-off of the at least one continuous stream of liquid into a stream of drops of predetermined volumes. A sensing apparatus adapted to detect the stream of drops of predetermined volumes is provided. A control apparatus is adapted to determine a characteristic of the stream of drops of predetermined volumes that is related to the break-off length. Further apparatus is adapted to inductively charge at least one drop and to cause electric field deflection of charged drops. Jet stimulation apparatus comprising a plurality of transducers corresponding to the plurality of nozzles and adapted to transfer pulses of energy to the liquid sufficient to cause the break-off of the plurality of continuous streams of liquid into a plurality of streams of drops of predetermined volumes is also disclosed. Methods of measuring the jet break-off length using phase sensitive amplification circuitry are disclosed.

Dust eliminator

End-tidal gas monitoring apparatus

A non-invasive monitoring apparatus for end-tidal gas concentrations, and a method of use thereof, is described for the detection of endogenous gas concentrations, including respiratory gases, in exhaled breath.

End-tidal gas monitoring apparatus

method for monitoring hydrogen sulfide in exhaled breath of a mammal, using an end-tidal gas monitoring apparatus, is disclosed. The method comprises the steps of: (a) determining a predetermined level of end tidal CO2 in exhaled breath collected from a mammal who has received parenteral administration of a sulfide-containing or sulfide-producing compound; (b) directing gas flow to a hydrogen sulfide sensor upon detection of the predetermined level of end tidal CO2; and (c) determining a level of the exhaled hydrogen sulfide in the exhaled breath. ation of a sulfide-containing or sulfide-producing compound; (b) directing gas flow to a hydrogen sulfide sensor upon detection of the predetermined level of end tidal CO2; and (c) determining a level of the exhaled hydrogen sulfide in the exhaled breath.

Thermoplastic polyarylate compositions having improved oxygen barrier properties

Aromatic thermoplastic polyarylates containing structural units derived from a bisphenol of cyclohexanone, preferably 1,1-bis(4-hydroxy-3-methylphenyl)cyclohexane, and an aromatic dicarboxylic acid or mixture of such acids, are provided which exhibit improved oxygen barrier properties.

Thermoplastic polyarylate compositions having improved oxygen barrier properties

RD-18,450 THERMOPLASTIC POLYARYLATE COMPOSITIONS HAVING IMPROVED OXYGEN BARRIER PROPERTIES Abstract of the Invention Aromatic thermoplastic polyarylates containing structural units derived from a bisphenol of cyclohexanone, preferably, 1,1-bis(4-hydroxy-3-methylphenyl)cyclohexane, and an aromatic dicarboxylic acid or mixture of such acids, are provided which exhibit improved oxygen barrier properties.

Linear motor for pumping

A linear actuator for pumping comprising a stator having an inner opening, a shaft having a plurality of permanent magnets spaced linearly in the axial direction, the shaft disposed in the stator opening and configured to reciprocate linearly in the axial direction relative to the stator, the stator comprising a first stator assembly having a plurality of pole sections spaced linearly in the axial direction and a plurality of coils disposed therebetween, a second stator assembly having a plurality of pole sections spaced linearly in the axial direction and a plurality of coils disposed therebetween, a bearing assembly positioned axially between the first stator assembly and the second stator assembly, and the bearing assembly having a width that is a function of the spacing of the plurality of pole sections of the first stator assembly and the second assembly and the spacing of the plurality of permanent magnets of the shaft.

Apoptosis modulator Bcl-B and methods for making and using same

A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human tissues. The Bcl-B protein modulates apoptosis. Bcl-B also binds Bcl-2, BCI-XL, and Bax but not Bak. Bcl-B displays a unique pattern of selectivity for binding and regulating the function of other members of the Bcl-2 family.

Methods for determining the prognosis for cancer patients using tucan

The invention provides methods for determining a prognosis for survival for a cancer patient. One method involves (a) measuring a level of a TUCAN in a neoplastic cell-containing sample from the cancer patient, and (b) comparing the level of TUCAN in the sample to a reference level of TUCAN, wherein a low level of TUCAN in the sample correlates with increased survival of the patient. Another method involves (a) measuring a level of TUCAN in a neoplastic cell-containing sample from the cancer patient, and (b) classifying the patient as belonging to either a first or second group of patients, wherein the first group of patients having low levels of TUCAN is classified as having an increased likelihood of survival compared to the second group of patients having high levels of TUCAN.

Cross-slide gesture to select and rearrange

Cross slide gestures for touch displays are described. In at least some embodiments, cross slide gestures can be used on content that pans or scrolls in one direction, to enable additional actions, such as content selection, drag and drop operations, and the like. In one or more embodiments, a cross slide gesture can be performed by dragging an item or object in a direction that is different from a scrolling direction. The different-direction drag can be mapped to additional actions or functionality. In one or more embodiments, one or more thresholds can be utilized, such as a distance threshold, in combination with the different-direction drag, to map to additional actions or functionality.

Card reader display system

The invention relates to a micro display system that utilizes a small high resolution active matrix liquid crystal display with an illumination system and a magnifying optical system to provide a hand held communication display device. The system can employ an LED illumination system and cellular communication or processor circuits within a compact housing to provide communication devices such as pagers, telephones, televisions, and hand held computer or card reader devices with a compact high resolution data and/or video display.

Systems, devices and methods for analysis

The subject disclosure presents, in some embodiments, is systems, devices and methods for multi-sample analyte analysis. In some such embodiments, a method is presented which includes labeling at least one target analyte in each of a plurality of individual samples with at least one unique label probe. The method further includes combining the plurality of individual samples into a mixture, and flowing the mixture within at least one fluidic channel/1 ane having arranged thereon or in fluid communication with at least one set of a plurality of spatially distinct capture zones. Embodiments of the present disclosure additionally relate to, among other things, systems, devices, and related methods for operating the same, to analyze and rapidly identify and quantify microbial pathogens in environmental, food, and clinical settings. Specifically, a rapid one-step FISH method where fixation, permeabilization and addition of fluorescent labeled probe all occur in one step on a ferrofluidic system.

Method of revivifying spent carbonaceous materials

Compressor rotor stack assembly for gas turbine engine

A compressor rotor assembly including a plurality of rotor disks axially spaced from each other, each rotor disk extending radially from an inner end to an outer end. Also included is a spacer extending axially from each rotor disk to engage an adjacent spacer extending from an adjacent rotor disk, the spacer and adjacent spacer disposed proximate the outer end of the respective rotor disks, the spacers forming an outer backbone of the compressor rotor assembly. Further included is an inner backbone of the compressor rotor assembly, the inner backbone comprising a plurality of backbone segments, each of the backbone segments extending axially from each rotor disk to engage an adjacent backbone segment extending from an adjacent rotor disk, the backbone segment and the adjacent backbone segment disposed proximate the inner end of the respective rotor disks.

Methods and compositions for derepression of iap-inhibited caspase

The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in Figures 5, 9, 10, 14B, and 21-24 wherein said agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The method consists of contacting an IAP-inhibited caspase with an effective amount of an agent to derepress an IAP-inhibited caspase, the agent having a core motif selected from the group consisting of a core peptide having a sequence set forth in any of Core peptides 4 through 39 and 42 through 55, and a core structure selected from the group consisting of TPI759, TPI882,TPI914 or TPI927. The methods of the invention also can be used for promoting apoptosis in a cell and for reducing the severity of a pathology characterized by reduced levels of apoptosis. Methods for identifying agents that derepress an IAP-inhibited caspase are also provided.

Systems and methods for intelligent gas source management and/or systems and methods for delivery of therapeutic gas and/or enhanced performance verification for therapeutic gas delivery

Therapy gas delivery systems that provide run-time-to-empty infomiation to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.

Improved method and apparatus for enamelling

Arranging tiles

This document describes techniques and apparatuses for arranging tiles. These techniques and apparatuses enable users to quickly and easily arrange tiles within an interface, such as an application-launching interface. In some cases, users may arrange tiles in an interface with as little as one continuous gesture.

Method and apparatus for molding and casting

SYSTEM FOR GENERATING LIGHT, IN PARTICULAR FOR PRODUCING A LASER LINE, WITH A GRADED BASE

Le système de génération de lumière (100) comprend :une base (104) comprenant une surface inférieure qui comprend une structure d'attachement non mécanique ; etun dispositif de génération de lumière (102) monté en rotation sur la base (104) autour d'un axe. The light generation system (100) comprises: a base (104) including a bottom surface that includes a non-mechanical attachment structure; anda light generating device (102) rotatably mounted on the base (104) about an axis.

LASER LINE GENERATING DEVICE WITH SWIVEL BASE

Un dispositif d'alignement à laser comprend un dispositif de génération de faisceau laser, une partie de monture supérieure (102), et une partie de monture inférieure (104). Le dispositif de génération de faisceau laser comprend un boîtier (12) et un générateur laser (10). La partie de monture supérieure (102) est disposée près d'un bas du boîtier, et la partie de monture inférieure (104) est fixée de façon pivotante et/ou rotative à la partie de monture supérieure (102).

Pyridine and pyrimidine carboxylate herbicides and methods of use thereof

Provided herein are pyridine and pyrimidine carboxylates and their derivatives, and compositions and methods of use thereof as herbicides.

Lignin nanoparticle dispersions and methods for producing and using the same

A mild, simple process of preparing lignin nanoparticle dispersions is disclosed. Additionally, compositions and methods of making lignin nanoparticlepolymer complexes comprising derivatized and/or non-derivatized lignin nanoparticle dispersions and water soluble and/or water dispersible polymers are disclosed. Further, methods of using at least one of the lignin nanoparticle dispersions, derivatized lignin nanoparticle dispersions, and/or the lignin nanoparticlepolymer complex to impart rinse-resistant properties, such as hydrophilic properties, to substrates, or function as tunable nanoparticle surfactants are disclosed.

Tapered ridge vent for the peak or ridge of a framed roof structure

A roof vent device formed from upper and lower outer surfaces sized to define a generally rectangular configuration having a linear axis. A tapered matrix is positioned between the outer surfaces, the taper being directed in a direction perpendicular to the axis to define a thin linear edge and a thick linear edge along the outer edges of the configuration that are parallel to the axis and tapered linear edges along the outer edges of the configuration that are perpendicular to the axis. The tapered matrix has a gap located proximate the middle of the tapered linear edges and extending generally over the linear axis of the outer surfaces. The gap defines an entrance for an air to vent air from beneath the roof ridge out the thick linear edge. The gap further provides a pivot point about which the configuration folds to conform to a roof pitch having a predetermined angle. In one embodiment the matrix is tapered from one outer edge to the gap and the remaining portion of the matrix is generally level. In the preferred embodiment, the taper extends from one linear edge to the other. In a preferred embodiment, a baffle extends out from the thick linear edge and is shaped to deflect outside air away from the thick linear edge without inhibiting air flow out of the linear edge from the air tunnel entrance.

Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses.

La invención se relaciona de manera general con polipéptidos multiespecíficos que tienen unión a CD3 restringida. En algunas modalidades, los componentes de los polipéptidos multiespecíficos se conectan por medio de un enlazante no escindible. También se proporcionan métodos para preparar y usar esos polipéptidos multiespecíficos en una variedad de indicaciones terapéuticas, de diagnóstico y profilácticas.

Multiplexed synchronization circuits for switching frequency synthesized signals

Multiplexers are used to generate synchronized slave clocks from a common master clock. A first multiplexer and a second multiplexer generate a first slave clock and a second slave clock, respectively, from the common master clock. A third multiplexer and a fourth multiplexer are configured as a divide-by-n circuit for providing a third slave clock that is a divided version of the second slave clock. A fifth multiplexer provides a matching delay to preserve the synchronization between the first slave clock and the other slave clocks. A sixth multiplexer is used to select between the second slave clock and the third slave clock in response to a select signal. A flip-flop may be used to provide the select signal and to guard against false selection of slave clocks.

Feeding device for rock drills

Virus scanner for journaling file system

A method is provided for detecting viruses. According to the method, data is stored in a journal area of memory before changes embodied in the data are written to virtual memory. At least a first portion of the data in the journal area of memory is scanned for viruses. In some embodiments, a second portion of data that immediately precedes and/or immediately follows data to which the first portion of the data pertains is scanned for viruses. Preferably, the virtual memory includes a persistent storage device. Also provided is a system that includes a processor, a memory that includes virtual memory and a journal storage area, and a virus scanner controlled by the processor. The virus scanner scans the journal storage area for viruses.

Rock drill

Compact high resolution light valve projector

The present invention relates to a light valve projector in which a small high resolution active matrix transmission display is used with a light source, coupling optics and a projection lens to provide a compact presentation system. A preferred embodiment of the system comprises a three light valve system with an arc lamp within a compact housing in which dichroic mirrors separate light from the source into three primary colors and directs the separated light through three active matrix displays manufactured by a thin film transfer process and having a small active area.

Drilling device

Adjusting speaker volume based on a future noise event

For adjusting speaker volume based on a future noise event, a method identifies, by a first electronic device, a future noise event. The method communicates the noise mitigation alert to a second electronic device. The method further adjusts, by the second electronic device, the speaker volume concurrent with the commencement of the future noise event.

Serpin fusion polypeptides and methods of use thereof.

Esta invención está relacionada moléculas, particularmente polipéptidos, más particularmente proteínas de fusión que incluyen un polipéptido de serpina o una secuencia de aminoácidos que se deriva de una serpina y un segundo polipéptido que comprende al menos uno de los siguientes: un polipéptido Fc o una secuencia de aminoácidos que se deriva de un polipéptido Fc; un polipéptido dirigido a citoquinas o una secuencia derivada de un polipéptido dirigido a citoquinas; un polipéptido que contiene un dominio WAP o una secuencia derivada de un polipéptido que contiene un dominio WAP; y un polipéptido de albúmina o una secuencia de aminoácidos que se deriva de un polipéptido de albúmina de suero; esta invención también esta relacionada a métodos para utilizar tales moléculas en una variedad de indicaciones terapéuticas y de diagnóstico, así como también métodos para producir tales moléculas.

Water-boiling containers

ABSTRACT An electrically-heated water boiling container (38) comprises an integral electric heater comprising a sheathed heating element (39) in good thermal contact with the underside of the bottom (40) of the container. A thermally sensitive electrical control (1, 2) including a switch-on-dry protector switch unit (2) makes direct electrical connection with cold leads (3) of the heating element (39) and includes thermally-sensitive switch means effective, in use, to interrupt the electrical supply to the heater and terminal pins adapted to be engaged by a female socket connector whereby electric connection of the heater to a mains supply can be made, said unit being mounted on a mounting plate (41) itself mounted on said container (38) in direct or indirect thermal contact with said heating element(39) whereby said plate conducts heat to said switch unit to cause said switch means to operate should the element overheat through being switched on dry or boiled dry.

Rock drill

Phosphoanhydrite process

A wet process for producing phosphoric acid and phosphoanhydrite by acidulation of phosphate rock with a phosphoric acid/sulfuric acid mixture containing a very high recycle content of small sized anhydrite seed crystals. A strong phosphoric acid is obtained having a concentration of at least about 35% P2O5. Further, the phosphoanhydrite may be readily converted to an industrially usable gypsum product.

Compensation for repeatable leakage errors

Portable drilling rig

Upper bifi frame for a gas turbine engine and methods therefor

An upper bifi frame for preventing air leakage in a gas turbine engine including an engine casing and a fan case is provided. The upper bifi frame includes a forward fairing having a forward fairing midsection extending between the engine casing and the fan case. The forward fairing has a forward fairing first end including a flange configured to couple to the engine casing. The forward fairing has a forward fairing second end extending from the forward fairing midsection and configured to couple to the fan case. At least one aft seal is secured to the forward fairing and forms a seal therewith. A wedge seal is coupled to the forward fairing and the at least one aft seal and is operative to prevent air leakage to a pylon that is secured to the engine casing.

Industrial shredding apparatus

The present invention comprises an industrial shredding apparatus which is usable in shredding many types of industrial waste, garbage, trash, and so forth. The shredding apparatus incorporates a pair of oppositely revolving shafts upon which are mounted respective sets of knives or cutting blades disposed such that the tips thereof form, compositely, helixlike configuration relative to each of the respective shafts. The blades are so arranged that they serve both in holding debris for cutting by adjacent blades, and, additionally, for cutting themselves in their own turn. The shredding mechanism is designed such that the cutting is done centrally of the apparatus, with associated structure being designed for urging debris falling thereon toward a central position relative to the apparatus. The device is ideally suited for shearing and/or cutting debris and allowing the same to pass through the shredder onto a transport conveyer, for example.

METHODS AND COMPOSITIONS FOR ANTAGONIZING ANTI-APOPTOTIC Bcl-2-FAMILY PROTEINS

The cytotoxic natural product gambogic acid (GA) competes for BH3 peptide binding sites on several anti-apoptotic members of the Bcl-2 family of proteins and neutralizes the ability of these proteins to suppress release of apoptogenic proteins from isolated mitochondria. Structure-function analysis of GA using analogs suggested a general correlation between BH3 competition and cytoxicity activity. Compositions and methods are provided for using GA and its derivatives for treating cancer and for discovering other compounds that are useful for treating cancer through their interaction with Bcl-2-family proteins.

Conversion of apoptotic proteins

Rock drilling apparatus

Low backlash-high-torque power transmission system and toothed belt used therein

A flexible power transmission belt having a plurality of teeth each of which has a pair of arcuate convex flank portions which in longitudinal cross-section closely approximate to an arc of a circle. Each tooth exhibits a height to width relationship within a predetermined range, and the arcuate flanks each have a pressure angle within a predetermined range. The belt is preferably used in combination with a toothed pulley whose teeth are substantially conjugate to the belt teeth and whose cavities between the teeth have a height to width relationship within another predetermined range and have concave flanks exhibiting a pressure angle in still another predetermined range, said belt tooth width being approximately 0.98 of the pulley cavity width so as to provide a high torque positive drive power transmission system having minimum backlash.

Lubricator

Thermal management system for a gas turbine engine

A gas turbine engine system for cooling engine components (290; 390) includes an engine core (70; 110; 210; 310), a core housing (112) containing the engine core (70; 110; 210; 310), an engine core driven fan (42) forward of the core housing (112), a nacelle (120; 220; 320) surrounding the fan (42) and the core housing (112), and a bypass duct (130; 230; 330) defined between an outer diameter (134; 234; 334) of the core housing (112) and an inner diameter (132; 232; 332) of the nacelle (120; 220; 320). A thermal management system having a coolant circuit includes at least one of a first heat exchanger (160; 260; 360) disposed on the inner diameter (132; 232; 332) of the nacelle (120; 220; 320) and a second heat exchanger (180; 280; 380) disposed on a leading edge of a bifurcation (BiFi) (170; 270; 370) spanning the bypass duct (130; 230; 330). The first heat exchanger (160; 260; 360) is in thermal communication with the second heat exchanger (180; 280; 380).

Method and system of billing for charging a vehicle battery leveraging a single connection action

A method and system provided for a single-action with which the customer places an order and receives goods by the single action of connecting an electrical vehicle (EV) to a charging station according to the business terms associated with this invention, the affiliated organizations that purchase or support the operation of the invention participate in a business “franchise” operation whereby all affiliated organizations increase their revenues as the volume of EV charging events increases.

Novel bag proteins and nucleic acid molecules encoding them

The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S. pombe (BAG-1A, BAG-1B) and the nucleic acid molecules that encode them.

Device and method for diffusing high concentration no with inhalation therapy gas

DEVICE AND METHOD FOR DIFFUSING HIGH CONCENTRATION NO WITH INHALATION THERAPY GAS At least one device for combining nitric oxide (NO) with other gases being administered to a patient for inhalation therapy is described. The device enables high concentration NO to be delivered into ventilator breathing circuits, via a diffusing device, without generating undesirably large amounts of NO2.

Multiple reporter gene assay

A method of measuring the activity of at least two reporter gene products in an aliquot of a sample extract is disclosed. The activities of a first and second reporter enzyme are quantified by measuring the light signal produced by degradation of a first substrate by the first reporter enzyme and the light signal produced by the degradation of a second substrate by a second reporter enzyme. Both quantifications are sequentially performed on the same aliquot of sample extract.

Tandem blade rotor disk

A tandem rotor disk apparatus may include a rotor disk body concentric about an axis. The tandem rotor disk apparatus may also include a first blade extending radially outward of the rotor disk body and a second blade extending radially outward of the rotor disk body. The first blade may be offset from the second blade in a direction parallel to the axis. The tandem rotor disk apparatus may be implemented in a gas turbine engine with no intervening stator vane stages disposed between the first blade and the second blade.

Lignin nanoparticle dispersions and methods for producing and using the same

A mild, simple process of preparing lignin nanoparticle dispersions is disclosed. Additionally, compositions and methods of making lignin nanoparticle—polymer complexes comprising derivatized and/or non-derivatized lignin nanoparticle dispersions and water soluble and/or water dispersible polymers are disclosed. Further, methods of using at least one of the lignin nanoparticle dispersions, derivatized lignin nanoparticle dispersions, and/or the lignin nanoparticle—polymer complex to impart rinse-resistant properties, such as hydrophilic properties, to substrates, or function as tunable nanoparticle surfactants are disclosed.

Shipping and installation for heating, ventilation, and air conditioning (HVAC)

A zone-control unit adapted for facile inclusion in a building's ductwork includes a mechanical terminal unit, inlet and outlet piping assemblies that are mechanically coupled together. The structure also includes at least one handle so the zone-control unit may be conveniently and safely handled both during shipping, and during installation into a HVAC system. Prior to installation into a HVAC system the fully-functional zone-control unit also includes a pair of caps respectively sealing the ends of the piping assemblies, and a pressure gauge for sensing pressurization of the piping assemblies and coil which the caps seal. Sealed in this way a pressure gauge permits testing to assure that the piping assemblies and coil are leak free, and readily assessing that zone-control units remain leak free until they are about to be installed into a building's HVAC system.

Method of making light emitting diode displays

Light emitting diodes (LEDs) and LED bars and LED arrays formed of semiconductive material, such as III-V, and particularly AlGaAs/CaAs material, are formed in very thin structures using organometallic vapor deposition (OMCVD). Semiconductor p-n junctions are formed as deposited using carbon as the p-type impurity dopant. Various lift-off methods are described which permit back side processing when the growth substrate is removed and also enable device registration for LED bars and arrays to be maintained.

Rock drill

Scouring pad and process for making same

A process and apparatus for impregnating a molten or viscous cleaning composition into a traveling, three dimensional, lofty, dense nonwoven web is disclosed. The composition is applied by an applicator manifold and is retained in the voids within the web. The velocity of the web and the flow of the cleaning composition are adjusted depending on the viscosity of the composition and the web density. Additionally, the viscosity of the composition can be controlled by altering its temperature or by altering the line pressure. The process eliminates the use of a doctor blade, spray system and application roll to meter the amount of cleaning composition into the web, and is suitable for the application of a molten or very viscous chemical compositions into a lofty, dense nonwoven web.

Ox40-binding polypeptides and their uses

Se proporcionan en este documento polipéptidos que contienen VHH que se unen a OX40. En algunas formas de realización, se proporcionan polipéptidos que contienen VHH que se unen a OX40 y lo agonizan. Se proporcionan además usos de los polipéptidos que contienen VHH.

Lignin nanoparticle dispersions and methods for producing and using the same

A mild, simple process of preparing lignin nanoparticle dispersions is disclosed. Additionally, compositions and methods of making lignin nanoparticlepolymer complexes comprising derivatized and/or non-derivatized lignin nanoparticle dispersions and water soluble and/or water dispersible polymers are disclosed. Further, methods of using at least one of the lignin nanoparticle dispersions, derivatized lignin nanoparticle dispersions, and/or the lignin nanoparticlepolymer complex to impart rinse-resistant properties, such as hydrophilic properties, to substrates, or function as tunable nanoparticle surfactants are disclosed.

Universal joint.

Metal body painting system and method

A method of manufacturing a body, preferrably an automotive vehicle body, to have a plurality of coating layers, starts with assembling the body out of parts made from pre-coated metal. A pretreatment step provides for paint adhesion and/or corrosion protection for cut edges, weld spots or metal finished areas. A powder paint base coat is then applied onto the pre-coated metal of the vehicle body. The pre-coat layer is one of the plurality of coating layers and the powder paint base coat is another one of the plurality of coating layers. In another embodiment, the powder paint base coat is applied in two steps, a first powder paint base coat and a color powder paint base coat. The first powder paint base coat is applied to a first portion of the vehicle body and the color powder paint base coat is applied to a second portion of the vehicle body. Unused first powder paint base coat and unused color powder paint base coat are both reclaimed, mixed, and the mixture used for at least some of the first powder paint base coat applied to the first portion of the vehicle body.

Keyed anesthetic vaporizer filling system

A system for facilitating the delivery of a liquid anesthetic agent from an anesthetic bottle (8) to an anesthetic vaporizer (10). The system includes a bottle adapter (10), an anesthetic bottle (8) and a filler arrangement positioned on the anesthetic vaporizer (9). The bottle adapter and filler arrangement each include a keyed configuration such that only the correct type of anesthetic agent can be emptied into the anesthetic vaporizer. The bottle adapter (10) includes an adapter valve assembly that engages a filler valve assembly contained within the filler. The dimensions and arrangement of the adapter valve assembly and the filler valve assembly ensure anesthetic agent is delivered to the anesthetic vaporizer only when the anesthetic agent can safely flow from the anesthetic bottle to the anesthetic vaporizer.

Coating with antifriction metal

The invention provides a method of, and apparatus for, producing a layer of antifriction metal on a metallic surface. The method involves using a die having a recess surrounded by a thin rim; the recess is filled with molten antifriction metal which is allowed to solidify, and thereafter the structure obtained is machined to remove unwanted parts of the die.

Embedded heat exchanger for heating, ventilatiion, and air conditioning (HVAC) systems and methods

A zone-control unit for use in a heating, ventilation, and air conditioning (HVAC) system, the zone-control unit includes a heat exchanger, an inlet piping assembly coupled with the heat exchanger for supplying fluid to the heat exchanger, an outlet piping assembly coupled with the heat exchanger for receiving fluid from the heat exchanger, a bracket that maintains the inlet piping assembly and the outlet piping assembly in positional relationship, and an ancillary component coupled with the heat exchanger.

Data processing and storage method and apparatus

Lamp globe fitting

Idle task monitor

A system and method are provided for determining processor usable idle time in a system employing a software instruction processor. The method establishes an idle task with a lowest processor priority for a processor executing application software instructions, and uses the processor to execute an idle task. The method ceases to execute the idle task in response to the processor executing application software instructions. The amount of periodic idle task execution is determined and stored in a tangible memory medium. For example, idle time amounts can be determined per a unit of time, i.e. a percentage per second. In one aspect, the method generates an idle task report. The report can be a periodic report expressing the duration of idle task execution per time period, or a course of execution report expressing idle task start times, idle task stop times, and durations between the corresponding start and stop times.

Bcl-2-associated proteins

The present invention provides nucleotide sequences encoding proteins and fragments thereof that bind to Bcl-2-related proteins. The invention also provides a Bcl-2-associated protein (BAP) such as the BAG-1, which is encoded by the Bcl-2-associated athanogene-1 and binds to Bcl-2. The invention also provides antibodies that specifically bind to a BAP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BAP such as BAG-1 or Raf-related protein with a Bcl-2-related protein and methods for detecting agents that induce dissociation of a bound complex formed by the association of a BAP and a Bcl-2-related protein. The invention further provides methods for modulating the activity of a Bcl-2-related protein in a cell by introducing into the cell a nucleic acid encoding a BAP or by introducing into the cell an antisense nucleotide sequence, which is complementary to a region of a gene encoding a BAP.