INSTALLATION OF TRANSPORT OF PARTS, IN PARTICULAR OF WORKPIECES

Konverter zum Oberwindfrischen mit Sauerstoff

PROTECTIVE BACK CONTACT LAYER FOR SOLAR CELLS

The present disclosure is directed toward a thin film photovoltaic cell including a support substrate; a contact layer disposed adjacent a first side of the substrate; a p-type semiconductor layer disposed on the first side of the substrate; an n-type semiconductor layer disposed on the first side of the substrate; and a protective back side layer structure disposed adjacent a second side of the substrate, wherein the protective back side layer structure may include a corrosion resistant material. In some embodiments, the back side layer includes at least a first layer and a second layer. Additionally and/or alternatively, the back side layer may include a molybdenum alloy, wherein the molybdenum alloy may include an alloy partner selected from the group consisting of Ti, Zr, Hf, V, Nb, Ta, Al, and Si. 1. A thin film photovoltaic cell , comprising:a support substrate having a first side and a second side,a contact layer disposed on the first side of the substrate,an absorber layer disposed on the first side of the substrate,a buffer layer disposed on the first side of the substrate, anda protective back side layer on the second side of the substrate, wherein the protective back side layer structure includes a corrosion resistant material.2. The thin film photovoltaic cell of claim 1 , wherein the back side layer includes at least a first layer and a second layer.3. The thin film photovoltaic cell of claim 2 , wherein the first layer includes chromium.4. The thin film photovoltaic cell of claim 3 , wherein the first layer including chromium is disposed directly adjacent the second side of the substrate.5. The thin film photovoltaic cell of claim 2 , wherein the second layer comprises the same material included in the contact layer on the first side of the substrate.6. The thin film photovoltaic cell of claim 1 , wherein the substrate has molybdenum deposited on the first side and the second side of the substrate.7. The thin film photovoltaic cell of claim 1 , wherein ...

Buffer layer deposition for thin-film solar cells

Improved methods and apparatus for forming thin-film buffer layers of chalcogenide on a substrate web. Solutions containing the reactants for the buffer layer or layers may be dispensed separately to the substrate web, rather than being mixed prior to their application. The web and/or the dispensed solutions may be heated by a plurality of heating elements.

METHODS OF INTEGRATING MULTIPLE MANAGEMENT DOMAINS

An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a users control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers. 1. A computer-implemented method of integrating data indicative of multiple sensed conditions received from multiple management domains , comprising:receiving, at a computer first data from a first management domain comprising an arrangement of mutually related systems, the first data being indicative of at least one sensed condition in at least one of said mutually related systems, wherein the first data is communicated according to a communications protocol and formatted according to an application interface, and wherein the mutually related systems include a plurality of networked devices each of which communicates to another of the devices;receiving, at the computer second data from a second management domain comprising an arrangement of mutually related systems, the second data being indicative of at least one sensed condition in at least one of the mutually related systems of the second management domain, wherein the second data is communicated according to the same communications protocol as the first data and formatted according to the same application interface as the first data, and wherein the mutually related systems include a plurality of networked devices each of which communicates to another ...

BARRIER AND PLANARIZATION LAYER FOR THIN-FILM PHOTOVOLTAIC CELL

Thin film photovoltaic cells and methods of manufacturing such cells that include one or more diffusion barrier layers configured to provide a relatively smooth growth surface for subsequent deposition of a p-type semiconductor layer. Diffusion barrier layers according to the present teachings may be amorphous, microcrystalline or nanocrystalline layers of materials including molybdenum, conductive oxides, conductive nitrides, conductive carbides, or mixtures thereof. In some cases a diffusion barrier layer may be configured to have surface roughness less than a predetermined threshold value. 1. A thin-film photovoltaic cell , comprising:an electrically conductive substrate;a first diffusion barrier layer disposed above the substrate;a p-type semiconductor layer disposed above the first diffusion barrier layer;an n-type semiconductor layer disposed above the p-type semiconductor layer;a front electrode layer disposed above the n-type semiconductor layer; anda collection grid disposed above the front electrode layer;wherein the first diffusion barrier layer is an amorphous layer including a material selected from the group consisting of molybdenum, conductive nitrides, conductive oxides, conductive carbides, and mixtures thereof.2. The thin-film photovoltaic cell of claim 1 , wherein the first diffusion barrier layer includes a material selected from the group consisting of aluminum doped zinc oxide (AZO) claim 1 , tin oxide (SnO) claim 1 , indium tin oxide (ITO) claim 1 , zinc tin oxide (SnZnO) and titanium nitride (TiN).3. The thin-film photovoltaic cell of claim 1 , wherein the first diffusion barrier layer is an amorphous layer of molybdenum.4. The thin-film photovoltaic cell of claim 1 , wherein the first diffusion barrier layer is a microcrystalline layer.5. The thin-film photovoltaic cell of claim 1 , wherein the first diffusion barrier layer is a nanocrystalline layer.6. The thin-film photovoltaic cell of claim 1 , wherein the first diffusion barrier layer is ...

Spring-loaded drive with active feedback in dc circuit

A motor control of a motor has a DC circuit with a back-up capacitor and a switching device that can connect a motor to the back-up capacitor. A spring device applies a restoring force to the rotor of the motor when deflected from an idle position. When the DC Circuit feeds energy into the back-up capacitor from a power supply network, a control device activates switching elements of the switching device to adjust an actual deflection of the rotor to a required deflection. When the rotor is deflected from the idle position and the back-up capacitor receives no energy from the power supply network, the control device, supplied with energy by the back-up capacitor, sets the required deflection to the idle position and activates the switching elements such that the motor, upon being restored by the spring device, feeds energy into the back-up capacitor via the switching elements.

METHOD AND DEVICE FOR DRIVING BRUSHLESS DIRECT-CURRENT MOTOR DURING DISPLACEMENT OF ACTUATING ELEMENT

During displacement of an actuating element to a target position, a brushless direct-current motor is driven by a driving commutation pattern derived from rotor position signals. After the target position is reached the brushless direct-current motor is transferred to a holding mode in which it is driven by a commutation pattern providing a required holding torque. In the holding mode the holding current necessary for providing the required holding torque is minimized by an iterative holding current reduction method to a holding current value guaranteeing the required holding torque. 1. A method for driving a brushless direct-current motor during the displacement of an actuating element , comprising:driving the brushless direct-current motor during the displacement of the actuating element to a target position by a driving commutation pattern derived from rotor position signals; andtransitioning the driving the brushless direct-current motor after the target position is reached s to a holding mode in which the driving is by a commutation pattern providing a required holding torque, using a holding current necessary to provide the required holding torque that is minimized by an iterative holding current reduction method to the holding current value guaranteeing the required holding torque.2. The method as claimed in claim 1 , wherein the rotor position signals are provided by Hall-effect sensors.3. The method as claimed in claim 2 , wherein a valve or throttle is displaced by the brushless direct-current motor.4. The method as claimed in claim 3 , wherein when a small required holding torque is present the holding current value is reduced to 0 A.5. The method as claimed in claim 3 , wherein the iterative holding current reduction method is aborted after a predefined number of cycles and the holding current value then present is used as the minimized holding current value.6. A device for driving a brushless direct-current motor during the displacement of an actuating ...

2,4-diamino-pyrimidines as aurora inhibitors

The present invention encompasses compounds of general formula (1) wherein R 1 to R 3 are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

SOLUTION CONTAINMENT DURING BUFFER LAYER DEPOSITION

Improved methods and apparatus for forming thin-film layers of chalcogenide on a substrate web. Solutions containing the reactants for the chalcogenide layer may be contained substantially to the front surface of the web, controlling the boundaries of the reaction and avoiding undesired deposition of chalcogenide upon the back side of the web. 1. A method of depositing a thin film chalcogenide buffer layer onto a flexible substrate , comprising:transporting a web of thin film substrate material through a deposition region by sliding the web over a support surface disposed within the deposition region;dispensing onto a top surface of the web a metal-containing solution containing a metal chosen from the group consisting of copper, silver, gold, zinc, cadmium, mercury, lead, boron, aluminum, gallium, indium and thallium, and a chalcogen-containing solution containing a chalcogen chosen from the group consisting of oxygen, sulfur, selenium and tellurium;lifting transverse edge portions of the web relative to a central portion of the web to contain at least a portion of the metal-containing solution and at least a portion of the chalcogen-containing solution substantially upon the top surface of the web; andholding the central portion of the web substantially flat with a plurality of magnets disposed in fixed positions under the central portion of the web.2. The method of claim 1 , wherein the transverse edge portions of the web are lifted by passing the web over a plurality of angled cylinders.3. The method of claim 2 , wherein the angled cylinders are configured to rotate with movement of the web.4. The method of claim 2 , wherein the angled cylinders are constructed from a low friction material claim 2 , and are configured to maintain a fixed rotational position as the web moves.5. The method of claim 1 , wherein the support surface includes a plurality of grooves configured to reduce the area of contact between the support surface and the web.6. The method of claim ...

METHODS OF INTEGRATING MULTIPLE MANAGEMENT DOMAINS

An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a user's control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers. 1. A computer-implemented method of integrating data indicative of multiple sensed conditions received from multiple management domains , comprising:receiving, at a computer first data from a first management domain comprising an arrangement of mutually related systems, the first data being indicative of at least one sensed condition in at least one of the mutually related systems, wherein the first data is communicated according to a communications protocol and formatted according to an application interface, and wherein the mutually related systems include a plurality of networked devices each of which communicates to another of the devices;receiving, at the computer second data from a second management domain comprising an arrangement of mutually related systems, the second data being indicative of at least one sensed condition in at least one of the mutually related systems of the second management domain, wherein the second data is communicated according to the communications protocol and formatted according to the application interface, wherein the mutually related systems include a plurality of networked devices each of which communicates to another of the devices in the second system;storing the ...

MOUNTING STRUCTURES FOR PHOTOVOLTAIC CELLS

Mounting systems for PV modules and assemblies of modules, including apparatus and methods of use. The disclosed systems generally involve mounting a flexible photovoltaic module in a slight arch, bending it with a large radius around one axis of the module. 1. A photovoltaic assembly , comprising: a body portion having a bottom surface configured to be attached to an underlying structure and a side support surface configured to support a lateral part of the photovoltaic module, and', 'a module retention portion configured to receive an edge portion of a photovoltaic module; and, 'first and second photovoltaic mounting structures, each includinga flexible photovoltaic module disposed between the mounting structures with a first edge of the module positioned within the module retention portion of the first mounting structure and a second edge of the module positioned within the module retention portion of the second mounting structure;wherein the first and second mounting structures are disposed a distance apart less than a distance between the first and second edges of the module, thereby causing the module to curve between the mounting structures.2. The assembly of claim 1 , wherein the module retention portion of each mounting structure is a groove of substantially constant width formed between the body portion and an overlap portion of each respective mounting structure.3. The assembly of claim 1 , wherein the module retention portion of each mounting structure is a gap that narrows toward its proximal end.4. The assembly of claim 1 , wherein the module retention portion of each mounting structure includes a pinch point that fixes the position of the module as the module passes through the pinch point.5. The assembly of claim 1 , wherein the module retention portion of each mounting structure is a narrowing gap terminating in a distal pinch point.6. The assembly of claim 1 , wherein the mounting structures are two-part structures with the module retention portion ...

ELECTRODE CUTTING INSTRUMENT

Systems and methods related to cutting electrodes (e.g. lithium metal) and electrode precursors are generally provided. The electrodes or electrode precursors may involve, for example, a lithium metal electrode or a lithium composite electrode, e.g., for use in an electrochemical cell or battery. 1. A system for cutting a lithium metal layer , comprising:an asymmetric blade, the asymmetric blade comprising a tip, a first edge, and a second edge, as shown in a cross-section of the blade;a first interleaf layer;a second interleaf layer, wherein the lithium metal layer is positioned between the first interleaf layer and the second interleaf layer; anda substrate positioned adjacent to the second interleaf layer.2. An electrode precursor , comprising:a first interleaf layer;a second interleaf layer;a lithium metal layer having a cross-section; andan optional protective layer adjacent the lithium metal layer,wherein the first and second interleaf layers are in conformal contact with the lithium metal layer and/or the optional protective layer, and wherein the first interleaf layer and the second interleaf layer surround a perimeter of the cross-section of the lithium metal layer and optional protective layer.3. A method for cutting lithium metal , the method comprising:positioning a layer of the lithium metal between a first interleaf layer and a second interleaf layer,cutting the lithium metal with a blade to form a cut lithium metal piece having a cross-section, wherein the cutting step does not cut through the first interleaf layer, andadhering the lithium metal to the first interleaf layer and/or the second interleaf layer such that the first interleaf layer and second interleaf layer surrounds a perimeter of the cross-section of the cut lithium metal piece.4. (canceled)5. The system of claim 1 , wherein the asymmetric blade has a longitudinal axis perpendicular to the substrate claim 1 , the longitudinal axis passing through the tip of the blade as shown in the ...

LOW POROSITY ELECTRODES AND RELATED METHODS

Electrodes and methods of preparing electrodes with a porous electroactive region are generally described herein. 1. An electrode , comprising: a lithium intercalation compound, and', 'an electronically conductive material;, 'a porous electroactive region, the porous electroactive region comprisingwherein the porous electroactive region has a porosity of less than or equal to 16%.2. An electrochemical cell , comprising: a lithium intercalation compound, and', 'an electronically conductive material;', 'wherein the porous electroactive region has a porosity of less than or equal to 16%;, 'a first electrode comprising a porous electroactive region, the porous electroactive region comprisinga second electrode; andan electrolyte in electrochemical communication with the first electrode and the second electrode.3. The electrode of claim 1 , wherein the porous electroactive region has an average cross-sectional pore diameter of less than or equal to 200 nanometers.4. An electrode claim 1 , comprising: a lithium intercalation compound, and', 'an electronically conductive material;, 'a porous electroactive region, the porous electroactive region comprisingwherein the porous electroactive region has an average cross-sectional pore diameter of less than or equal to 200 nanometers.5. An electrochemical cell claim 1 , comprising: a lithium intercalation compound, and', 'an electronically conductive material;', 'wherein the porous electroactive region has an average cross-sectional pore diameter of less than or equal to 200 nanometers;, 'a first electrode comprising a porous electroactive region, the porous electroactive region comprisinga second electrode; andan electrolyte in electrochemical communication with the first electrode and the second electrode.6. The electrode of claim 4 , wherein the porous electroactive region has a porosity of less than or equal to 16%.7. The electrochemical cell of claim 2 , wherein the electrolyte comprises a liquid electrolyte.8. The electrode ...

CROSS-FLOW FILTRATION SYSTEM FOR VITICULTURE

A cross-flow filtration system for filtering a suspension, such as but not limited to a viniculture suspension, may include a plurality of hollow fibre modules for retaining a retentate of the suspension. A circulation pump may be fluidically connected to the hollow fibre modules for facilitating a mechanical flow of the suspension. A flow distributor may distribute the suspension to the hollow fibre modules. A flow collector may collect the suspension of the hollow fibre modules. The flow distributor and the flow collector may be fluidically connected to the circulation pump and the hollow fibre modules. The hollow fibre modules may be arranged coaxially to each other about a longitudinal axis of the cross-flow filtration system. 1. A cross-flow filtration system for filtering a suspension , comprising:a plurality of cylindrical-shaped hollow fibre modules for retaining a retentate of a suspension,a circulation pump fluidically connected to the plurality of hollow fibre modules for facilitating a mechanical flow of the suspension,a flow distributor for distributing the suspension to the plurality of hollow fibre modules, anda flow collector for collecting the suspension from the plurality of hollow fibre modules,wherein the flow distributor and the flow collector are fluidically connected to the circulation pump and the plurality of hollow fibre modules and are arranged substantially centrally on a longitudinal axis, andwherein the plurality of hollow fibre modules are arranged coaxially to each other about the longitudinal axis.2. The cross-flow filtration system according to claim 1 , wherein the flow distributor includes a body of rotation having a point and a peripheral lateral surface claim 1 , arranged in such manner that the flow distributor distributes the suspension substantially evenly to the plurality of hollow fibre modules when the circulation pump directs the flow at the point.3. The cross-flow filtration system according to claim 2 , wherein the ...

HETEROBICYCLIC N-AMINOPHENYL-AMIDES AS INHIBITORS OF HISTONE DEACETYLASE

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula (I) or any one of Compounds 100-175) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment. 2. The compound of claim 1 , wherein Ris selected from:6,7-dihydrothiazolo[5,4-c]pyridin-2-yl,4,5,6,7-tetrahydrothiazolo[4,5-c]pyridin-2-yl,4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl,2-oxa-8-azaspiro[4.5]decan-8-yl,1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl,2,8-diazaspiro[4.5]decan-8-yl,2,8-diazaspiro[4.5]decan-2-yl,hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl,5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-2-yl,5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl,2-oxa-7-azaspiro[3.5]nonan-7-yl,5,7-dihydro-6H-pyrrolo[3,4-b]pyrazin-6-yl,octahydro-5H-pyrrolo[3,4-c]pyridin-5-yl,5-oxa-2-azaspiro[3.5]nonan-2-yl,5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl,8-oxa-2-azaspiro[4.5]decan-2-yl,7-oxa-2-azaspiro[3.5]nonan-2-yl,2,7-diazaspiro[3.5]nonan-2-yl,2,7-diazaspiro[3.5]nonan-7-yl,2,7-diazaspiro[4.4]nonan-2-yloctahydro-2H-pyrrolo[3,4-c]pyridin-2-yl,3,8-diazabicyclo[3.2.1]octan-3-yl,3,8-diazabicyclo[3.2.1]octan-8-yl,3,8-diazabicyclo[3.2.1]octan-8-yl,2,5-diazabicyclo[2.2.1]heptan-2-yl,8-oxa-3-azabicyclo[3.2.1]octan-3-yl,5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-yl,6,7-dihydro-4H-pyrano[4,3-d]thiazol-2-yl,5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl,2-oxa-6-azaspiro[3.4]octan-6-yl,2-oxa-6-azaspiro[3.3]heptan-6-yl, and{'sup': '1', '2,6-diazaspiro[3.4]octan-6-yl, wherein Ris optionally substituted with up to 4 independently selected substituents.'}6. The compound of claim 5 , wherein Ris selected from para-substituted phenyl claim 5 , pyridinyl claim 5 , furanyl ...

HETERO-HALO INHIBITORS OF HISTONE DEACETYLASE

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment. 2. (canceled)3. The compound of claim 1 , wherein n is 0.4. (canceled)5. (canceled)7. The compound of claim 3 , wherein Ris selected from 5 claim 3 ,7-dihydro-6H-pyrrolo[3 claim 3 ,4-b]pyrazin-6-yl claim 3 , pyrrolidin-1-yl claim 3 , 1 claim 3 ,3-dihydro-2H-pyrrolo[3 claim 3 ,4-c]pyridin-2-yl claim 3 , 6 claim 3 ,7-dihydro-5H-pyrrolo[3 claim 3 ,4-b]pyridin-6-yl claim 3 , tetrahydro-2H-pyran-4-yl claim 3 , hexahydrocyclopenta[c]pyrrol-2(1H)-yl claim 3 , 7-oxa-2-azaspiro[3.5]nonan-2-yl claim 3 , isoindolin-2-yl claim 3 , 4 claim 3 ,5 claim 3 ,6 claim 3 ,7-tetrahydrothiazolo[4 claim 3 ,5-c]pyridin-2-yl claim 3 , 2-oxa-7-azaspiro[3.5]nonan-7-yl claim 3 , 2-oxa-6-azaspiro[3.3]heptan-6-yl claim 3 , and 2-oxa-6-azaspiro[3.4]octan-6-yl claim 3 , wherein Ris optionally substituted with up to 3 independently selected substituents.8. The compound of claim 7 , wherein Ris selected from 5 claim 7 ,7-dihydro-6H-pyrrolo[3 claim 7 ,4-b]pyrazin-6-yl claim 7 , pyrrolidin-1-yl claim 7 , 1 claim 7 ,3-dihydro-2H-pyrrolo[3 claim 7 ,4-c]pyridin-2-yl claim 7 , 6 claim 7 ,7-dihydro-5H-pyrrolo[3 claim 7 ,4-b]pyridin-6-yl claim 7 , tetrahydro-2H-pyran-4-yl claim 7 , hexahydrocyclopenta[c]pyrrol-2(1H)-yl claim 7 , 7-oxa-2-azaspiro[3.5]nonan-2-yl claim 7 , isoindolin-2-yl claim 7 , 4 claim 7 ,6-difluoroisoindolin-2-yl claim 7 , 4 claim 7 ,7-difluoroisoindolin-2-yl claim 7 , 4-fluoroisoindolin-2-yl claim 7 , 5-fluoroisoindolin-2- ...

INHIBITORS OF HISTONE DEACETYLASE

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula (I), (II), (IIa), (III), (IV), (V), or (VI)) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment. 2. The compound of claim 1 , wherein:{'sup': '1', 'Ris hydrogen;'}{'sup': '2', 'Ris selected from hydrogen, fluoro, chloro, methyl, methoxy, amino, methylcarbonylamino, methylcarbonyl-N-methylamino, dimethylamino, t-butoxycarbonylamino, 2-oxopyrrolidin-1-yl, trifluoromethylcarbonylamino, isopropylcarbonylamino, and phenylcarbonylamino; and'}{'sup': '3', 'Ris selected from hydrogen, fluoro, chloro and methyl, or'}{'sup': 2', '3, 'Rand Rare taken together to form 1H-benzo[d]imidazol-5-yl'}3. The compound of claim 1 , wherein X is C(O).4. The compound of claim 1 , wherein Y is S.5. The compound of claim 1 , wherein Ris selected from hydrogen claim 1 , C-Calkyl claim 1 , C-Calkenyl claim 1 , C-Ccycloalkyl claim 1 , and phenyl.6. The compound of claim 5 , wherein Ris selected from hydrogen claim 5 , methyl claim 5 , ethyl claim 5 , isopropyl claim 5 , 1-propenyl claim 5 , cyclopropyl claim 5 , cyclopentyl and phenyl.7. The compound of claim 1 , wherein Ris selected from hydrogen claim 1 , hydroxy claim 1 , methyl and ethyl.8. The compound of claim 1 , wherein Z is N.9. The compound of claim 1 , wherein ring A is phenyl or cyclopentyl.1114-. (canceled)1627-. (canceled)2963-. (canceled) This application claims benefit of U.S. Provisional Application No. 62/017,688, filed Jun. 26, 2014, which is incorporated by reference in its entirety.Inhibitors of histone deacetylases (HDAC) have been shown to modulate transcription and to ...

HETERO-HALO INHIBITORS OF HISTONE DEACETYLASE

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment. 133-. (canceled) This application is a continuation of U.S. application Ser. No. 16/726,990, filed Dec. 26, 2019, which is a continuation of U.S. application Ser. No. 15/741,657, filed Jan. 3, 2018, which is a § 371 national stage filing of International Application No. PCT/US2016/040957, filed Jul. 5, 2016, which claims the benefit of U.S. Provisional Application No. 62/188,857, filed Jul. 6, 2015, the entire contents of each of which are incorporated herein by reference.This invention was made with government support under Small Business Innovation Research (SBIR) grant 1R43AG048651-01A1 awarded by the National Institute of Health (NIH). The government has certain rights in the invention.Inhibitors of histone deacetylases (HDAC) have been shown to modulate transcription and to induce cell growth arrest, differentiation and apoptosis. HDAC inhibitors also enhance the cytotoxic effects of therapeutic agents used in cancer treatment, including radiation and chemotherapeutic drugs. Marks, P., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T., Kelly, W. K. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer, 1, 194-202, (2001); and Marks, P. A., Richon, V. M., Miller, T., Kelly, W. K. Histone deacetylase inhibitors. Adv Cancer Res, 91, 137-168, (2004). Moreover, recent evidence indicates that transcriptional dysregulation may contribute to the molecular pathogenesis of certain ...

FEEDBACK FOR BUFFER LAYER DEPOSITION

Improved methods and apparatus for forming thin film layers of chalcogenide on a substrate web. According to the present teachings, a feedback control system may be employed to measure one or more properties of the web and/or the chalcogenide layer, and to adjust one or more parameters of the system or buffer layer deposition method in response to the measurement. 1. A method of depositing a thin film chalcogenide buffer layer onto a flexible substrate , comprising:transporting a web of thin film substrate material through a deposition region by passing the web over a transport mechanism disposed within the deposition region;dispensing onto a top surface of the web a metal-containing solution containing a metal chosen from the group consisting of copper, silver, gold, zinc, cadmium, mercury, lead, boron, aluminum, gallium, indium and thallium, and a chalcogen-containing solution containing a chalcogen chosen from the group consisting of oxygen, sulfur, selenium and tellurium;lifting transverse edge portions of the web relative to a central portion of the web to contain at least a portion of the metal-containing solution and at least a portion of the chalcogen-containing solution substantially upon the top surface of the web; andholding the central portion of the web substantially flat;wherein holding the central portion of the web substantially flat includes holding the web in contact with the transport mechanism at discrete positions within the deposition region by passing the web underneath a plurality of wheels, each wheel disposed directly above a portion of the transport mechanism and between the central portion and one of the lifted transverse edge portions of the web, and configured to hold the web in contact with that portion of the transport mechanism.2. The method of claim 1 , wherein the transport mechanism is configured to transport the web out of physical contact with a web heating mechanism.3. The method of claim 1 , wherein the transport mechanism has ...

HETERO-HALO INHIBITORS OF HISTONE DEACETYLASE

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment. 133-. (canceled) This application claims the benefit of U.S. Provisional Application No. 62/188,857, filed Jul. 6, 2015, the entire contents of which are incorporated herein by reference.Inhibitors of histone deacetylases (HDAC) have been shown to modulate transcription and to induce cell growth arrest, differentiation and apoptosis. HDAC inhibitors also enhance the cytotoxic effects of therapeutic agents used in cancer treatment, including radiation and chemotherapeutic drugs. Marks, P., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T., Kelly, W. K. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer, 1, 194-202, (2001); and Marks, P. A., Richon, V. M., Miller, T., Kelly, W. K. Histone deacetylase inhibitors. Adv Cancer Res, 91, 137-168, (2004). Moreover, recent evidence indicates that transcriptional dysregulation may contribute to the molecular pathogenesis of certain neurodegenerative disorders, such as Huntington's disease, spinal muscular atrophy, amyotropic lateral sclerosis, and ischemia. Langley, B., Gensert, J. M., Beal, M. F., Ratan, R. R. Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents. Curr Drug Targets CNS Neurol Disord, 4, 41-50, (2005). A recent review has summarized the evidence that aberrant histone acetyltransferase (HAT) and histone deacetylases ( ...

Flexible building-integrated photovoltaic structure

Improved BIPV materials configured to meet various long-term requirements including, among others, a high degree of water resistance, physical durability, electrical durability, and an ability to withstand variations in temperature and other environmental conditions. In some embodiments, the disclosed BIPV materials include modules wherein two or more layers of the module are configured to be joined together during lamination to protect edge portions of the top sheet and/or back sheet of the module, such as in the vicinity of any multi-layer vapor barrier structure(s) of the module.

HIGH SPEED MULTI-AXIS MACHINE TOOL

An apparatus and method are provided for three dimensional planing of a workpiece. The apparatus includes a base, a displaceable machine table supported on that base, a displaceable spindle supported on the base adjacent the machine table, a cutting tool held in a chuck carried on the spindle and a control module. The control module includes a controller and a plurality of actuators to provide precise displacement of the machine table, spindle, cutting tool and the workpiece for planing surface features into the workpiece. 1. An apparatus comprising:a base;a displaceable machine table supported on the base;a displaceable spindle supported on the base adjacent the machine table, said spindle including a chuck;a cutting tool held in said chuck on said spindle; anda control module including a controller adapted to control an X-axis actuator, a Y-axis actuator and a Z-axis actuator whereby precise relative movement of said displaceable machine table and said displaceable spindle is provided for three dimensional planing of a workpiece held on said machine table.2. The apparatus of wherein said X-axis actuator is held on said base and adapted to displace said displaceable machine table in an X-axis direction.3. The apparatus of claim 2 , wherein said Y-axis actuator is held on said base and adapted to displace said displaceable machine table in a Y-axis direction.4. The apparatus of claim 3 , wherein said Z-axis actuator is held on said base and adapted to displace said displaceable spindle in a Z-axis direction toward or away from said displaceable machine table.5. The apparatus of claim 4 , wherein said control module further includes a spindle actuator adapted to index claim 4 , rotate and align the cutting tool held in the chuck for proper engagement and clearance with the workpiece held on the displaceable machine table.6. The apparatus of claim 5 , wherein said control module further includes a workpiece actuator parallel to one of the X-axis and the Y-axis of the ...

METHODS OF INTEGRATING MULTIPLE MANAGEMENT DOMAINS

An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a users control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers. 1. A computer-implemented method of integrating data indicative of multiple sensed conditions received from multiple management domains , comprising:receiving, at a computer first data from a first management domain comprising an arrangement of mutually related systems, the first data being indicative of at least one sensed condition in at least one of said mutually related systems, wherein the first data is communicated according to a communications protocol and formatted according to an application interface, and wherein the mutually related systems include a plurality of networked devices each of which communicates to another of the devices;receiving, at the computer second data from a second management domain comprising an arrangement of mutually related systems, the second data being indicative of at least one sensed condition in at least one of the mutually related systems of the second management domain, wherein the second data is communicated according to the same communications protocol as the first data and formatted according to the same application interface as the first data, and wherein the mutually related systems include a plurality of networked devices each of which communicates to another ...

BUFFER LAYER DEPOSITION FOR THIN-FILM SOLAR CELLS

Improved methods and apparatus for forming thin-film buffer layers of chalcogenide on a substrate web. Solutions containing the reactants for the buffer layer or layers may be dispensed separately to the substrate web, rather than being mixed prior to their application. The web and/or the dispensed solutions may be heated by a plurality of heating elements. 1. A method of producing a flexible thin film photovoltaic material comprising:depositing a p-type absorber layer on a continuous length of flexible substrate;conveying continuously the flexible substrate through a deposition path; and dispensing onto the p-type absorber layer, at a first longitudinal position along the path, a first solution containing zinc, and', 'dispensing onto the p-type absorber layer, at a second a longitudinal position along the path, a second solution containing a chalcogen selected from the group including oxygen, sulfur, and selenium;, 'forming an n-type layer on the p-type absorber layer bywherein the second position is located beyond the first position by a sufficient distance to allow time for an ion exchange reaction between zinc in the first solution and the p-type absorber layer, in a region between the first position and the second position.2. The method of claim 1 , wherein the first solution includes zinc sulfate.3. The method of claim 1 , wherein the second solution includes thiourea.4. The method of claim 1 , further comprising heating the first solution to a temperature greater than the temperature of the moving web prior to application of the first solution to the web.5. The method of claim 4 , wherein heating the first solution includes heating the first solution to a temperature in the range of 55-70 degrees Celsius.6. The method of claim 1 , wherein the second position is disposed beyond the first position in the longitudinal direction.7. The method of claim 1 , further comprising dispensing onto the web claim 1 , at a third longitudinal position disposed beyond the ...

TESTBED DEVICE FOR USE IN PREDICTIVE MODELLING OF MANUFACTURING PROCESSES

A testbed device includes high performance actuators, a video microscopy system and a plurality of high resolution, throughput sensors adapted or configured for collecting data that may be used in predictive modelling of machine processes. 1. A testbed device , comprising:a base;a displaceable machine table supported on the base;a sample holder supported on the displaceable machine table;a displaceable spindle supported on the base;a video microscopy system, including a camera, a microscope and a light source;a plurality of sensors adapted to measure force, vibration and thermal emission; anda control module including a controller, an X-actuator, a Y-actuator and a Z-actuator wherein the controller is adapted to (a) control the X-actuator, the Y-actuator and the Z-actuator, (b) receive data from the plurality of sensors and (c) receive data images from the video microscopy system.2. The testbed device of claim 1 , further including a tool holder carried on the displaceable spindle claim 1 , the tool holder being adapted to hold a cutting or burnishing tool.3. The testbed device of claim 2 , wherein the plurality of sensors include a tool acoustic emission sensor integrated into the tool holder.4. The testbed device of claim 3 , wherein the plurality of sensors include a sample acoustic emission sensor integrated into the sample holder.5. The testbed device of claim 4 , wherein the plurality of sensors include a tangential force load cell integrated into the tool holder.6. The testbed device of claim 5 , wherein the plurality of sensors include at least one vertical force load cell integrated into the displaceable machine table.7. The testbed device of claim 6 , further including a carbon fiber rod assembly integrated into the tool holder claim 6 , a first laser interferometer targeting a first target element at a first end of the carbon fiber rod along a first line and a second laser interferometer targeting a second target element at a second end of the carbon ...

Establishing document relevance by semantic network density

A computer implemented method, data processing system, and computer program product for establishing document relevance by semantic network density. When a search query is received, one or more semantic networks are identified which contain nodes matching one or more terms in the search query. An edge density is determined for each node matching a term in the search query. A relevancy score is then calculated for each of the one or more semantic networks based on the edge densities of the nodes matching a term in the search query. Based on the relevancy score, the relevancy to the search query of a document associated with the one or more semantic networks may then be determined.

Pyrimidine derivatives

The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0R a to R e are defined as in claim 1 , which are suitable for the treatment of illnesses characterised by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.

PIRIMIDINE DERIVATIVES, MEDICATIONS CONTAINING THESE COMPOUNDS, THEIR EMPLOYMENT AND PROCEDURE FOR PREPARATION

La presente invención se refiere a pirimidinas trisustituidas de la fórmula (I), en donde Ra a Re están definidas como en la reivindicación 1, las cuales son adecuadas para el tratamiento de enfermedades que están caracterizadas por una proliferación celular excesiva o anormal, a su empleo para la preparación de un medicamento con las propiedades precedentemente mencionadas, y a un procedimiento para su preparación. The present invention relates to trisubstituted pyrimidines of the formula (I), wherein Ra to Re are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, at their use for the preparation of a medicament with the aforementioned properties, and a procedure for its preparation.

Pyrimidine derivatives

The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0R a to R e are defined as in claim 1 , which are suitable for the treatment of illnesses characterized by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.

Patent DE3335057C2

Patent DE3324108C2

Scraper chain conveyor trough section

The trough section is for a scraper-chain conveyor, particularly as used in mines, and comprises a bottom between lateral profiled sections. The latter each comprise a top flange extending towards the middle, a bottom flange, and an intermediate web accommodating the bottom between itself and the corresponding flange on the opposite profiled section. The bottom flange is formed by a profiled bar guiding the scraper bars in the top and bottom runs.The bottom profiled bar (5) is of U-section and has a top flange (9) parallel to the bottom one and forming a support for a top profiled bar (6,7), also of U-section. An external connecting bar (22) is fixed to the bottom one, forming a lateral support for the top one, and protrudes above the top flange.(9)

COMPOUNDS DERIVED FROM PIRIMIDINE AND PHARMACEUTICAL COMPOSITION BASED ON THEM

La presente comprende compuestos de la formula general (1) en donde X es N o CH; y R1 es cicloalquilo C3-10, sustituido con R3 y eventualmente con uno o varios R4; y R2 es un radical seleccionado del grupo compuesto por H, halogeno, -CN, -NO2, alquilo C1-4, haloalquilo C1-4, cicloalquilo C3-10, cicloalquilalquilo C4-16 y aril-alquilo C7-16; y R3 es un radical apropiado seleccionado del grupo compuesto por -C(O)Rc, -C(O)ORc, -C(O)NRcRc, -S(O)2Rc, -N(Rf)S(O)2Rc, -N(Rf)C(O)Rc, -N(Rf)C(O)ORc, y -N(Rf)C(O)NRcRc; y R4 es un radical seleccionado del grupo compuesto por Ra, Rb y Ra sustituido con uno o varios Rc y/o Rb iguales o diferentes; y cada Ra está seleccionado, de modo independiente entre sí, del grupo compuesto por alquilo C1-6, cicloalquilo C3-10, cicloalquilalquilo C4-16, arilo C6-10, arilalquilo C7-16, heteroalquilo de 2-6 miembros, heterocicloalquilo de 3-8 miembros, heterocicloalquilalquilo de 4-14 miembros, heteroarilo de 5-12 miembros y heteroarilalquilo de 6-18 miembros; y cada Rb es un radical apropiado y está seleccionado, de modo independiente entre sí, del grupo compuesto por =O, -ORc, haloalquiloxi C1-3, -OCF3, =S, -SRc, =NRc, =NORc, -NRcRc, halogeno, -CF3, -CN, -NC, -OCN, -SCN, -NO2, -S(O)Rc, - S(O)2Rc, -S(O)2ORc, -S(O)NRcRc, -S(O)2NRcRc, -OS(O)Rc, -OS(O)2Rc, -OS(O)2ORc, -OS(O)2NRcRc, -C(O)Rc, -C(O)ORc, -C(O)NRcRc, -CN(Rf)NRcRc, -CN(OH)Rc, -CN(OH)NRcRc, -OC(O)Rc, -OC(O)ORc, -OC(O)NRcRc, -OCN(Rf)NRcRc, -N(Rf)C(O)Rc, -N(Rf)C(S)Rc, - N(Rf)S(O)2Rc, -N(Rf)C(O)ORc, -N(Rf)C(O)NRcRc, -[N(Rf)C(O)]2Rc, -N[C(O)]2Rc, -N[C(O)]2ORc, -[N(Rf)C(O)]2ORc y -N(Rf)CN(Rf)NRcRc; y cada Rc es, de modo independiente entre sí, hidrogeno o un radical eventualmente sustituido con uno o varios Rd y/o Re iguales o diferentes seleccionado del grupo compuesto por alquilo C1-6, cicloalquilo C3-10, cicloalquilalquilo C4-11, arilo C6-10, arilalquilo C7-16, heteroalquilo de 2-6 miembros, heterocicloalquilo de 3-8 miembros, heterocicloalquilalquilo de 4-14 miembros, heteroarilo de 5-12 ...

New compounds

The present invention encompassescompounds of general formula (1) wherein R1 to R4 , X and n are defined as in claim 1, which are suitable for the treatment of ailments characterised byexcessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

GUTTER SECTION FOR A SQUEEGEE CONVEYOR, TO BE USED IN PARTICULAR IN MINING OPERATIONS

LA BARRE PROFILEE INFERIEURE 5 EST, DE PREFERENCE, PROFILEE DE FACON A POUVOIR GUIDER A VOLONTE LES RACLETTES DES CONVOYEURS A RACLETTES A CHAINES CENTRALES COURANTS OU LES RACLETTES USUELLES RELIEES A DES CHAINES EXTERIEURES. POUR LES BARRES PROFILEES SUPERIEURES 6, ON PEUT, DANS CE CAS, UTILISER DES PROFILS DIFFERENTS, SELON QUE LE TRONCON DE GOUTTIERE EST UTILISE AVEC DES CONVOYEURS A RACLETTES A CHAINES CENTRALES OU A CHAINE EXTERIEURE DOUBLE. DE FACON APPROPRIEE, DES BARRES DE RACCORDEMENT 22 OU DE SUPPORT DE REHAUSSE SONT RELIEES D'UN SEUL TENANT AUX BARRES PROFILEES INFERIEURES 5; ELLES PEUVENT COMPORTER PLUSIEURS RANGEES DE DECOUPURES POUR FIXER PAR VISSAGE DES COMPOSANTS ADDITIONNELS. THE LOWER PROFILED BAR 5 IS PREFERABLY PROFILED IN A WAY TO BE ABLE TO GUIDE AT WILL THE SQUEEGEE CONVEYORS WITH CURRENT CENTRAL CHAIN RACLETS OR THE USUAL SQUEEGEES CONNECTED TO EXTERNAL CHAINS. FOR THE TOP 6 PROFILED BARS, IN THIS CASE, DIFFERENT PROFILES CAN BE USED, DEPENDING ON WHETHER THE GUTTER TRUNK IS USED WITH CENTRAL CHAIN OR DOUBLE EXTERIOR CHAIN SQUEEGEE CONVEYORS. APPROPRIATELY, CONNECTION BARS 22 OR EXTENSION SUPPORT BARS ARE CONNECTED ONLY TO THE LOWER PROFILE BARS 5; THEY MAY HAVE SEVERAL ROWS OF CUT-OUTS TO FIX ADDITIONAL COMPONENTS BY SCREWING.

SIDE SHEET FOR SQUEEGEE CONVEYOR

GUTTER SECTION FOR SQUEEGEE CHAIN CONVEYOR

BUCKET MECHANISM FOR THE ADVANCE OF A SLAUGHTER, ESPECIALLY FOR A DRUM HARVESTER

CORRIDOR SECTION FOR SQUEEGEE CONVEYOR WITH INTERCHANGEABLE TRANSPORT TRUCK

SELON L'INVENTION, L'AUGE DE TRANSPORT INTERCHANGEABLE 2 EST RELIEE A L'INFRASTRUCTURE 1 DU COULOIR DU TRANSPORTEUR FORMANT LE PARCOURS DE RETOUR DU CONVOYEUR A CHAINE A RACLETTES PAR DES BOULONS DE FIXATION VERTICAUX 18 ET DES PIECES DE VERROUILLAGE 19, QUI SONT DISPOSES DANS DES EVIDEMENTS DES LISIERES DE RACCORDEMENT VERTICALES (PLAQUES LATERALES 5) DE L'INFRASTRUCTURE 1. LES PIECES DE VERROUILLAGE 19 SONT CONSTITUEES PAR DES ELEMENTS DE VERROUILLAGE AMOVIBLES POUVANT ETRE RETIRES DES PROFILES LATERAUX 8 DE L'AUGE DE TRANSPORT 5, CES ELEMENTS PENETRANT AVANTAGEUSEMENT PAR DES SAILLIES OU GRIFFES 23 DANS DES OUVERTURES OU GORGES DE VERROUILLAGE 24 DES PROFILES LATERAUX 8 DE L'AUGE DE TRANSPORT2. DE PREFERENCE, DES PIECES DE SUPPORT 15 SONT SOUDEES SUR LES PROFILES LATERAUX 8 DE L'AUGE DE TRANSPORT 2 DANS LA PARTIE INFERIEURE DES EVIDEMENTS 14 DES PROFILES, PIECES AU MOYEN DESQUELLES L'AUGE DE TRANSPORT 2 S'APPUIE SUR DES SURFACES DE SUPPORT DES LISIERES DE RACCORDEMENT 5. ACCORDING TO THE INVENTION, THE INTERCHANGEABLE TRANSPORT TRUCK 2 IS CONNECTED TO THE CARRIER CORRIDOR INFRASTRUCTURE 1 FORMING THE RETURN PATH OF THE SQUEEGEE CHAIN CONVEYOR BY VERTICAL FIXING BOLTS 18 AND LOCKING PARTS 19, WHICH ARE VERTICAL CONNECTION SLIDES (SIDE PLATES 5) OF THE INFRASTRUCTURE 1. THE LOCKING PARTS 19 ARE CONSISTED BY REMOVABLE LOCKING ELEMENTS THAT CAN BE REMOVED FROM THE SIDE PROFILES 8 OF THESE TRANSPORT TRUCKS 5. ENHANCING ADVANTAGEOUSLY THROUGH PROJECTIONS OR CLAWS 23 IN LOCKING OPENINGS OR GROOVES 24 OF THE SIDE PROFILES 8 OF THE TRANSPORT TRUCK 2. PREFERENCE, SUPPORT PARTS 15 ARE WELDED ON THE SIDE PROFILES 8 OF THE TRANSPORT TRUCK 2 IN THE LOWER PART OF THE RECESSES 14 OF THE PROFILES, PIECES BY MEANS OF WHICH THE TRANSPORT TRUCK 2 LIES ON THE SUPPORT SURFACES CONNECTION SLIDES 5.

Roof water outlet

Channel section for conveyor with scraper chains

SI LE TRONCON DE GOUTTIERE COMPREND UNE AUGE DE COMPARTIMENT INFERIEUR ET UNE AUGE DE TRANSPORT 2 POUVANT ETRE SEPAREE ET REMPLACEE, L'AUGE DE TRANSPORT EST RELIEE A L'AUGE DE COMPARTIMENT INFERIEUR PAR DES PIECES DE RACCORDEMENT 13 QUI SONT FIXEES EXTERIEUREMENT AUX BARRES PROFILEES DE L'AUGE DE TRANSPORT ET S'APPUIENT SUR DES BUTEES QUI SONT SOUDEES DANS DES CREUX 17 OUVERTS VERS LE HAUT DES BARRES DE RACCORDEMENT DE L'AUGE DE COMPARTIMENT INFERIEUR. ON REALISE ALORS L'ASSEMBLAGE, DE FACON APPROPRIEE, AU MOYEN DE VIS DE FIXATION VERTICALE 19. ON PREVOIT, EN OUTRE, UN ASSEMBLAGE DE TRONCONS DE GOUTTIERE DANS LEQUEL UNE ATTACHE CONNUE EN SOI EST INSEREE DE L'INTERIEUR DU TRONCON DANS UNE POCHE POUR ATTACHE, FORMEE DANS DES PIECES DE RACCORDEMENT QUI SONT FIXEES DANS DES CREUX SE TROUVANT AUX EXTREMITES DES BARRES DE RACCORDEMENT DES BARRES PROFILEES DE L'AUGE DE COMPARTIMENT INFERIEUR.

AUTOMATIC APPARATUS AND METHOD FOR IMPLEMENTING THE SAME

Appareil automatique (12, 14) telle que commande programmable à mémoire comprenant une unité de commande (20) qui effectue des actions de transmission et/ ou de réception de données d'unités périphériques (30) pendant le temps de fonctionnement de l'appareil automatique (12, 14), caractérisé en ce que l'appareil automatique (12, 14) comporte un module (32) pour la saisie du temps de fonctionnement et/ ou des actions de l'appareil automatique (12, 14), et le module (32) est couplé à une unité d'exploitation (38, 46) pour calculer un coût d'utilisation à la charge de l'utilisateur de l'appareil automatique (12, 14). Automatic apparatus (12, 14) such as a memory programmable controller comprising a control unit (20) which performs data transmission and / or reception actions of peripheral units (30) during the operating time of the apparatus automatic device (12, 14), characterized in that the automatic device (12, 14) comprises a module (32) for recording the operating time and / or actions of the automatic device (12, 14), and the module (32) is coupled to an operating unit (38, 46) to calculate a cost of use to be borne by the user of the automatic device (12, 14).

CORRIDOR SECTION FOR SQUEEGEE CONVEYOR WITH INTERCHANGEABLE TRANSPORT TRUCK

KNIFE ARRANGEMENT, PARTICULARLY FOR COAL PLANER

POUR RETENIR LE COIN DE FORME COURBE A L'ETAT COINCE QUAND IL S'AGIT D'UN AGENCEMENT DE COUTEAU, IL EST PREVU, SELON L'INVENTION, UN DISPOSITIF D'ARRET DISPOSE DANS L'INTERSTICE EN COIN DE FORME COURBE 16, QUI EST MUNI D'UN ORGANE D'ARRET DEFORMABLE SOUS L'EFFET DE COINCEMENT DU COIN DE FORME COURBE 16, QUI MAINTIENT LE COIN PAR FROTTEMENT ETOU CONCORDANCE DE FORMES. L'ORGANE D'ARRET EST CONSTITUE DE PREFERENCE PAR UN CORPS EN MATIERE PLASTIQUE VISCOELASTIQUE QUI COOPERE AVEC UNE DENTURE D'ARRET 19. TO RETAIN THE CURVED CORNER IN THE STUCK STATE WHEN IT IS A KNIFE ARRANGEMENT, ACCORDING TO THE INVENTION, A STOP DEVICE IS PROVIDED IN THE INTERSTICE IN A CURVED CORNER 16, WHICH IS EQUIPPED WITH A STOPPER DEFORMABLE UNDER THE WINGING EFFECT OF THE CORNER OF CURVED SHAPE 16, WHICH MAINTAIN THE CORNER BY FRICTION AND OR CONCORDANCE OF SHAPES. THE STOPPING ORGAN IS PREFERABLY CONSISTED BY A BODY IN VISCOELASTIC PLASTIC MATERIAL WHICH COOPERATES WITH A STOP TOOTH 19.

METHOD FOR ADJUSTING THE WORKFLOW OF PARTS IN A PRODUCTION SYSTEM

Procédé pour régler un flux de pièces dans un système de production (10) concernant les pièces (16) avec des agents de pièce (18), des machines (12) pour usiner les pièces (16) et des agents de machine (14), des moyens de transport (20, 22, 24, 26, 28) pour transporter les pièces (16) entre les machines (12), et des agents de transport (30). Pour obtenir un système de production flexible qui tolère au moins des défaillances partielles de composants du système, au moins une machine (12) est attribuée avec une certaine adresse de machine (Mn) à chaque agent de transport (30) qui a pour mission de transporter la pièce (16) vers l'adresse de destination (Mz) et qui commande le moyen de transport (20) de manière autonome, pour transporter la pièce (16) vers l'adresse de machine de destination (Mz) par une certaine sortie cible (A1-A4). A method of controlling a workpiece flow in a production system (10) relating to the workpieces (16) with workpiece agents (18), machines (12) for machining the parts (16) and machine agents (14) , transport means (20, 22, 24, 26, 28) for transporting the parts (16) between the machines (12), and transport agents (30). To achieve a flexible production system that tolerates at least partial failures of system components, at least one machine (12) is assigned with a certain machine address (Mn) to each transport agent (30) who is responsible for transport the workpiece (16) to the destination address (Mz) and which controls the transport means (20) autonomously, to transport the workpiece (16) to the destination machine address (Mz) by a certain target output (A1-A4).

2,4-DI(aminopheyl) pyrimidines AS PKL inhibitors

Hetero-halo inhibitors of histone deacetylase

Solution containment during buffer layer deposition

Improved methods and apparatus for forming thin-film layers of chalcogenide on a substrate web. Solutions containing the reactants for the chalcogenide layer may be contained substantially to the front surface of the web, controlling the boundaries of the reaction and avoiding undesired deposition of chalcogenide upon the back side of the web.

Transportation system for transporting objects

The invention relates to a transportation system ( 10 ) for transporting objects (WSx), in particular workpieces, including a plurality of parallel or substantially parallel transportation paths ( 12, 14, 16 ) and a device ( 18 ) for shifting the objects (WSx) between at least two adjacent transportation paths ( 12, 14, 16 ). In order to reduce both the space required for the transportation path and the time consumption for displacing the workpieces between the transportation paths, it is proposed that the transportation paths ( 12, 14, 16 ) are disposed one above the other in different planes, and that the workpieces (WSx) on being shifted are moved on a path ( 30 ) that defines a plane extending perpendicular or substantially perpendicular to the transportation paths ( 12, 14, 16 ).

Process and mechanism for the production of electric heaters.

Scraper-chain conveyor channel section

DRIVE STICK ARRANGEMENT FOR THE FEED OF A WINNING MACHINE, IN PARTICULAR A ROLLING MOLDING MACHINE

Method and device for the production of coatings, in particular of metal.

Buffer layer deposition for thin-film solar cells

Improved methods and apparatus for forming thin-film buffer layers of chalcogenide on a substrate web. Solutions containing the reactants for the buffer layer or layers may be dispensed separately to the substrate web, rather than being mixed prior to their application. The web and/or the dispensed solutions may be heated by a plurality of heating elements.

Channel sections of scraper-chain conveyors

A conveyor channel section or pan is composed of upper and lower components each having U-shaped rolled side walls with inwardly-directed flanges and floor plates. Additional side plates fixed to the exteriors of the side walls of the lower component project upwardly alongside the side walls of the upper component. Recesses in the side plates mate with fittings on the side walls of the upper component and upstanding nuts and bolts secure the fittings in the recesses. The end regions of the pan can be provided with inclined deep pockets formed within welded-in shaped joining pieces which receive toggle-like coupling pieces used to connact adjacent pans together.

Chain assembly arresting apparatus for double outer scraper chain conveyors

The invention relates to a chain assembly arresting apparatus 1 for double outer scraper chain conveyors, having holding bodies 17 which laterally engage in a positive-locking manner around the chain assemblies 2 and can be fixed on the lateral profile sections 4 of a special channel length 3. The object of the invention is further to develop such a chain assembly arresting apparatus to the effect that a positive-locking arresting of the chain assemblies 2 in the lower strand 18 is possible. According to the invention, the special channel length 3 is provided with a closable bottom plate opening 15 and the holding bodies 17 are designed in such a manner that they reach through the bottom plate opening 15 and arrest the chain assemblies 2 of the lower strand 18, which are guided in the side profile 4, in a positive-locking manner (Figure 5). <IMAGE>

Scraper chain conveyor

Developer cartridge including sealing gasket

A developer cartridge for containing a developer and for delivering the developer to a developer hopper of an electro-photographic machine. A developer containment portion includes a first portion having an at least partially closed volume configured to contain the developer and a second portion adjacent the first portion and having an opening configured to deliver the developer to the developer hopper. A sealing gasket is disposed adjacent the second portion of the developer containment portion and surrounds at least a portion of a circumference of the opening. A first cover is disposed adjacent the second portion of the developer containment portion and is positionable between an open position for delivery of the developer and a closed position for preventing delivery of the developer. The sealing gasket contacts the first cover to prevent undesired leakage of the developer therebetween.

Process and device for the production of electrical heating elements by means of the metal spraying process

Device for covering the joint between two construction parts

1. Device for covering the joint between two construction parts, especially a roof covering or a r of edge bordering, with a center strip (1) made of rubber-elastic material (synthetic rubber) and two sheet metal edge strips (3) to be connected with parts of the construction located on both sides of the joint, as well as with a sheet metal covering (9) provided above the center strip (1) the sheet metal covering being vulcanized onto the synthetic rubber strip (1) along the upper side and the central area thereof, characterized in that the sheet metal covering (9) is vulcanized continuously along the entire length of the device with a width (5) that is substantially narrower than the area between the inner edges (3b) of the sheet metal edge strips (3).

Transportable crusher unit

The invention relates to a crusher unit that can be transported directly on roadways, the crusher being mounted on an elongated, rigid frame which is supported by several travel mechanisms or support trestles which rest directly on the ground underneath. The frame has several hydraulic jacks which are adjustable in height and lift the travel mechanisms or support trestles from the ground when the jacks are extended. In order to reduce the height of this crusher unit during transportation, the invention proposes that the travel mechanisms or support trestles be removed for transportation. This is achieved by means of quick-release fastening mechanisms and by arranging and dimensioning the jacks such that there is sufficient room under the frame to drive a transport vehicle which can be used on roadways.

Preloaded iol injector

A preloaded intraocular lens injection device (10) includes a retainer (40) for releasably holding an IOL (30) in an unstressed state. The retainer and IOL are removably attached to an injector body (12) and are sealed in the same package for delivery to a surgeon. In an alternate embodiment, the retainer and IOL are coupled together and sealed in one package and the injector body is sealed in a separate package with the surgeon attaching the retainer to the injector body at the time of surgery. To deliver the IOL through the injector body, the retainer is removed from the injector body causing the IOL to release from the retainer and become located in an unstressed state in the injector body. A compressor is moved to the closed position to compress the IOL, the injector tip (18a) is inserted through a small incision in an eye and a plunger (20) is advanced to push the IOL through and out the injector body tip and into an eye.

ANGLE CONNECTION FOR OVERCLOSES

Dihydropteridinones, method for the production thereof, and use thereof as a medicament

The invention relates to novel dihydropteridinones of general formula (I), wherein the radicals R<SUP>1</SUP> to R<SUP>5</SUP>, R<SUP>a</SUP> to R<SUP>c</SUP>, W, Q<SUB>1</SUB>, and Q<SUB>2</SUB> have the meanings indicated in the claims and the description, the isomers thereof, and the use thereof for producing a medicament that is used for the treatment of diseases characterized by excessive or anomalous cell proliferation.

Advanced tool for straightening pivots

Flexible building-integrated photovoltaic structure

Verbesserte BIPV-Materialien, die zur Erfüllung verschiedener Langzeit-Anforderungen ausgelegt sind, die, unter anderem, ein hohes Maß an Wasserfestigkeit, physikalischer Dauerhaltbarkeit, elektrischer Dauerhaltbarkeit und einer Fähigkeit zum Standhalten von Veränderungen einer Temperatur und anderen Umweltbedingungen umfassen. In einigen Ausführungsbeispielen umfassen die offenbarten BIPV-Materialien Module, wobei zwei oder mehr Schichten der Module zur Verbinden miteinander während einer Laminierung ausgelegt sind, um Randbereiche der Oberseitenplatte und/oder Unterseitenplatte des Moduls, wie z. B. in der Nähe einer (von) Dampfsperrenstruktur(en), zu schützen. Improved BIPV materials designed to meet various long-term requirements, including, but not limited to, high levels of water resistance, physical durability, electrical durability, and ability to withstand changes in temperature and other environmental conditions. In some embodiments, the disclosed BIPV materials include modules wherein two or more layers of the modules are configured to bond together during lamination to provide edge regions of the top and / or bottom side panels of the module, such as, for example. B. in the vicinity of a (of) vapor barrier structure (s) to protect.

Sprocket wheel

A sprocket wheel has a plurality of equi-spaced circumferential teeth, and a plurality of pockets positioned between the teeth. A central circumferential groove in the sprocket wheel divides each of the teeth into two parts. Each of the pockets is shaped to engage with a link of a drive chain, each of the pockets being formed partially by flanks provided on each of the two parts of each of the pair of adjacent teeth defining that pocket. The flanks constitute chain link bearing faces, and each of the flanks has at least three separate bearing surfaces.

Heating for buffer layer deposition

Improved methods and apparatus for forming thin film buffer layers of chalcogenide on a substrate web through the chemical combination of a metal and chalcogen in solution form. The web and/or the solutions may be heated by one or a plurality of heating elements that may be disposed out of physical contact with the web, allowing enhanced control over the reaction speed through fine temperature control. One or more properties of the chalcogenide layer may be measured, and the temperature of the system may be adjusted in response.

Thiazolyl-dihydro-indazoles

The present invention encompasses compounds of the general formula (1) in which R 1 to R 3 are defined as in claim 1 , which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.

Pyrimidine derivatives, pharmaceutical agent containing said compounds, use and method for making same

The invention concerns tri-substituted pyrimidines of formula (I), wherein Ra to Re are such as defined in the description, said compounds being used for treating diseases characterized by excessive or abnormal cell proliferation. The invention also concerns the use of said compounds for making a pharmaceutical agent exhibiting said properties, as well as methods for making said compounds.

Lance head for puddling lance

LANCE HEAD FOR PUDDLING LANCE Abstract The specification discloses a lance head for puddling lances having a plurality of expansion nozzles diverging from the longitudinal axis towards the bath surface, a cooling medium supply duct and a cooling medium return duct, the ducts being arranged parallel to the longitudinal axis, and flow conducting means between the ducts for cooling the lance head and for altering the direction of flow of the cooling medium. The flow conducting means comprises a flow deflector member on a pipe delimiting the supply and return ducts and extending in a direction towards the longitudinal axis, the flow deflector member being spaced from the bottom of the lance head and being concave, in the radial vicinity of the cross-sectionally narrowing expansion nozzles, at its side facing towards the bottom plate. The lance heads of this invention have been found to have considerably longer life than the conventional lance heads.

β-PHENYLALANINE DERIVATIVES AS INTEGRIN ANTAGONISTS

The present invention relates to compounds of general formula (1), wherein R4 is -SO¿2?R?4', -COOR4', -COR4', -CONR4'¿2 or -CSNR4'2; R4' is hydrogen, a substituted or unsubstituted alkyl or cycloalkyl residue, a substituted or unsubstituted aryl residue or a saturated or unsaturated, optionally substituted heterocyclic residue; R4' is a substituted or unsubstituted alkyl or cycloalkyl residue, a substituted or unsubstituted aryl residue or a saturated or unsaturated, optionally substituted heterocyclic residue; L is a sulphonamide, amide, ether, ester, keto, urea, thioether, sulphoxide or sulphone unit optionally extended by one or two methylene groups; and X is N, O or S; and their physiologically acceptable salts and stereoisomers. The present invention furthermore relates to a process for the preparation of the compounds of formula (1), a pharmaceutical composition containing at least one of these compounds, and the use of compounds of formula (1) for the production of a pharmaceutical composition having integrin-antagonistic action and in particular for the inhibition of angiogenesis and/or for the therapy and prophylaxis of cancer, osteolytic diseases such as osteoporosis, arteriosclerosis, restenosis and ophthalmic disorders.

Air spring system for a two-axle motor vehicle

Die Erfindung betrifft ein Luftfedersystem für ein zweiachsiges Kraftfahrzeug mit einer Druckluftquelle sowie den einzelnen Fahrzeugrädern zugeordneten Steuerventilen, über welche die jeweiligen Fahrzeugrad-Luftfedern wahlweise mit einer mit der Druckluftquelle verbundenen Druckluft-Versorgungsleitung verbindbar sind, wobei für die Luftfedern der Fahrzeug-Vorderachse sowie für diejenigen der Fahrzeug-Hinterachse eigene Druckluft-Leitungszweige vorgesehen sind, die sich zumindest abschnittsweise in ihrem Strömungsquerschnitt unterscheiden, und wobei der Leitungszweig einer der beiden Achsen derart ausgebildet ist, daß sich dessen Strömungsquerschnitt bei Druckluft-Zufuhr in die zugeordneten Luftfedern zumindest abschnittsweise vom Strömungsquerschnitt bei Druckluft-Abfuhr aus den zugeordneten Luftfedern unterscheidet. Bevorzugt besteht derjenige Leitungszweig, dessen Strömungsquerschnitt sich bei Druckluft-Zufuhr von demjenigen bei Druckluft-Abfuhr unterscheidet, aus parallel zueinander geschalteten Teilzweigen mit zumindest abschnittsweise unterschiedlichen Strömungsquerschnitten, wobei zumindest in einem der Teilzweige ein geeignet angeordnetes, diesen Teilzweig nur in einer Strömungsrichtung freigebendes Rückschlagventil vorgesehen ist. The invention relates to an air spring system for a two-axle motor vehicle with a compressed air source and control valves assigned to the individual vehicle wheels, via which the respective vehicle wheel air springs can be optionally connected to a compressed air supply line connected to the compressed air source, the air springs for the vehicle front axle and for those the vehicle rear axle is provided with its own compressed air line branches, which differ at least in sections in terms of their flow cross section, and the line branch of one of the two axes is designed such that its flow cross section, when compressed air is fed into the associated air springs, at least in sections from the flow cross section in the case of ...

Method and device for operating a brushless direct-current motor when adjusting a positioning element

Collaborative automation system and method for the control thereof

The invention relates to a collaborative automation system (PS), comprising devices providing divided production and control services (D) such as transport and processing machines (M) with associated device agents (ST-AG, MA-AG), products with associated product agents (WP-AG), and a coordination unit (CO) providing a communication platform (SKP); the invention further relates to a method for the control of such a system. In order to obtain a dynamic detection and calling of processes in a loosely coupled production structure and infrastructure, the invention provides for devices (ST, MA, WP) providing the production and control services to be associated with a DPWS-based web service (ST-WS; MA-WS), wherein device functions are implemented into the DPWS-based web service as device service and agent functions. The communication platform (SKP) is designed as a uniform, DPWS-oriented SOA platform. The devices (ST, MA, WP) providing production and control services communicate via an integrated DPWS-based web service (ST-WS; MA-WS) and via a single communication platform (SKP), wherein device functions are implemented as device services (ST-WS; MA-WS) and agent functions describing device agents (ST-AG; MA-AG; WP-AG) as agent services in the DPWS-based web service. The communication platform is used as a uniform, DPWS-oriented SOA platform.

2,4-di(aminophenyl)pyrimidine derivatives as plk inhibitors

Pyrimidines as PLK inhibitors

The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

KNIFE ARRANGEMENT, PARTICULARLY FOR COAL PLANER

computer-implemented method for integrating multiple management domains

MÉTODOS PARA INTEGRAR MÚLTIPLOS DOMÍNIOS DE GERENCIAMENTO. Uma estratégia de solução integrada que integra múltiplos domínios em conjunto de forma transparente e padronizado para aumentar o controle do usuário sobre instalações e equipamentos. Esta abordagem integrada pode levar a uma redução do consumo de energia, o uso de energia mais eficiente, maior segurança, saúde e segurança de uma instalação e seus ocupantes, produção otimizada em ambiente industriais, e associada e outras vantagens econômicas. informação precisa e confiável sobre uma instalação ou equipamento é essencial para tomar decisões informadas em tempo. Automação aprimorada fornece um meio confiável de coleta e montagem de uma variedade de dados operacionais e arquivamento dos dados em um banco de dados central para avaliação, relatórios, previsões, e negociação com os comerciantes de recursos. METHODS FOR INTEGRATING MULTIPLE MANAGEMENT AREAS. An integrated solution strategy that integrates multiple domains together in a transparent and standardized way to increase user control over facilities and equipment. This integrated approach can lead to a reduction in energy consumption, more efficient energy use, greater safety, health and safety for a facility and its occupants, optimized production in industrial environments, and associated and other economic advantages. Accurate and reliable information about a facility or equipment is essential for making informed decisions in time. Enhanced automation provides a reliable means of collecting and assembling a variety of operational data and archiving the data in a central database for assessment, reporting, forecasting, and negotiation with resource traders.

Compounds

The present invention encompasses compounds of general formula (1) wherein R 1 to R 4 , X and n are defined as in claim 1 , which are suitable for the treatment of ailments characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Lantern-gear arrangement for the advance of a mining machine, in particular a shearer machine

The invention relates to a lantern-gear arrangement for the advance of a mining machine, in particular a shearer machine, running on a face conveyor. The lantern gear consists of individual rack sections which are connected to the trough pans of the face conveyor in such a way as to be movable in the longitudinal direction, which trough pans can be angled relative to one another. According to the invention, the rack sections are arranged with clearance of motion between guide strips which are firmly connected to the supporting strips and on which the mining machine is guided with its sliding skids. Here, the rack sections are secured between the parallel guide strips to the supporting strips with clearance of motion, preferably by means of vertical coupling pins which pass through openings in the supporting strips. In this arrangement, the rack sections are removed from the high guide forces of the mining machine.

Cover strip for expansion joint - has edge areas on both sides covered with inextensible material

The covering strip is for an expansion joint in a building. This covering strip is made from an elastic material such as synthetic rubber. The strip has a middle portion (1) which covers the area of the joint and two edge areas (3). These edge areas are covered with an inextensible material which is impregnated with a sealing or adhesive medium. One side of the strip has its edges covered with this inextensible material. In this addition to the patent both sides have their edges covered with this inextensible material (5). USE - Covering strips for expansion joints.

Conveyor unit for transporting objects such as work pieces

The unit (10) encompasses several parallel transport tracks (12,14,16) as well as a device (18) for transferring the objects (WSx) between two neighboring tracks. The tracks are located above one another in different vertical planes and the objects are moved to a transfer track (30) in order to move them, where the track runs in a direction normal to the direction of the main transport tracks.

Alpha-carbolines as cdk-1 inhibitors

The present invention embraces compounds of the general formula (I) in which R2 to R5 and X are as defined in Claim 1, these compounds being suitable for treating diseases characterized by excessive or abnormal cell proliferation, and also embraces their use for producing a medicinal product having the aforementioned properties.

2, 4 -diamino pyrimidines as cell cycle kinase inhibitors

The present invention relates to compounds of the general formula (1) in which R1, R2, R4, Rg, X, m, n and p are as defined in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and to the use thereof for the manufacture of a medicament having the aforementioned properties.

Ethernet connectors

A modular ethernet-connector includes a jack ( 70 ) as part of a device ( 62 ) such as industrial automation device with embedded Ethernet connectivity ( 66 ), and a corresponding plug, the plug ( 94 ) being part of a WLAN-stick ( 82 ) which includes an embedded Ethernet-WLAN-Bridge ( 84 ).

Patent DE3230382C2

Preparation for the prevention and / or treatment and / or prevention of the spread of respiratory diseases.

Die vorliegende Erfindung betrifft eine Zubereitung zur Prävention und/oder Behandlung und/oder Verhinderung der Weiterverbreitung von Atemwegserkrankungen, welche durch Viren induziert werden und von bakteriellen Infektionen begleitet sein können, welche dadurch gekennzeichnet ist, dass diese Zubereitung als aktive Komponente einen Extrakt aus wenigstens einer Echinacea-Art oder deren Subspecies enthält, und dass diese Zubereitung entweder in einer solchen Form vorliegt, welche zur Inhalation und/oder für die pulmonale und/oder nasale und/oder buccale und/oder okulare und/oder parenterale, insbesondere die intravenöse oder subkutane, Verabreichung geeignet ist, oder in einer solchen Form vorliegt, welche die Viren am Eindringen in den menschlichen und/oder tierischen Körper hindert, mit der Massgabe, dass die nasale Verabreichung dieser Zubereitung in der Form von Nasentropfen, Nasensprays, Dosierungssprays und Nasensalben zur Behandlung von Virusinfektionen des Nasen-Rachen-Raumes ausgenommen ist. The present invention relates to a preparation for the prevention and / or treatment and / or prevention of the spread of respiratory diseases which are induced by viruses and may be accompanied by bacterial infections, which is characterized in that this preparation contains as active component an extract of at least one Echinacea species or their subspecies, and that this preparation is either in such a form, which for inhalation and / or for the pulmonary and / or nasal and / or buccal and / or ocular and / or parenteral, in particular the intravenous or subcutaneous , Administration, or in such form which prevents the viruses from entering the human and / or animal body, with the proviso that the nasal administration of this preparation is in the form of nasal drops, nasal sprays, dosage sprays and nasal ointments for treatment of nasopharyngeal virus infections excepted.

Photovoltaic submodule

Cross-flow filter for wine

2,4-di(aminophenyl)pyrimidine derivatives as plk inhibitors

The invention relates to compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1, and R3 are defined as indicated in claim 1. Said compounds are used for the treatment of diseases characterized by excessive or anomalous cell proliferation. Also disclosed is the use of the inventive compounds for producing a medicament having said properties.

Oxyhydrogen torch

Automation device with control program and method for programming thereof

The invention relates to an automation device (12, 16, 18) with an execution mechanism (26) for control programs (28, 30, 32) and also a web-services stack (38) for communication with other automation devices (12, 16, 18) and/or automation software, and also to a method for programming thereof. For programming and configuration of the control program, the invention provides that the automation device (12, 16, 18) has an integrated, web-based programming interface (42). The method comprises the following steps: Set up of a connection between the web browser (22) and a web-based programming interface (42) integrated in the automation device (12, 16,18), display of a programmer/configuration application in the web browser (22), generation of at least one control program (28, 30, 32) by use of a programming language, configuration of a web service (40) for access to the at least one control program (28, 30, 32).

Pyrimidine derivates, medicaments comprising them, their use and process of their preparation

Die vorliegende Erfindung betrifft trisubstituierte Pyrimidine der Formel (I) worin R a bis R e wie im Anspruch 1 definiert sind, welche zur Behandlung von Krankheiten, die durch exzessive oder anomale Zellproliferation charakterisiert sind, geeignet sind, deren Verwendung zur Herstellung eines Arzneimittels mit den vorstehend erwähnten Eigenschaften, und Verfahren zu ihrer Herstellung.

2,4-di (aminophenyl) pyrimidines AS PLK inhibitors.

Hetero-halo inhibitors of histone deacetylase

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.

Intelligent machine vision system for in-process tool wear monitoring

An intelligent machine vision system for in-process monitoring of wear of a cutting tool includes a machine vision camera, a microscope, and a light source adapted for lighting the cutting tool to allow collection of cutting tool images with the machine vision camera. A CDC cutting machine for in-process monitoring of a cutting tool incorporates this machine camera vision system. Further, a method of in-process monitoring of a machine cutting tool includes the steps of displacing a spindle of the machine cutting tool to position the machine cutting tool held in the spindle for monitoring with a machine vision camera and collecting at least one image of a first cutting edge of the cutting tool.

Improved raf inhibitors

The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Conjugates of integrin receptor antagonists and a cytostatic agent having specifically cleavable linking units

The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to .alpha.~v.beta.~3 integrin antagonists via preferred linking units which can be selectively cleaved by enzymes such as metallo matrixproteases (MMPs), i.e. by enzymes which can especially be foun d in tumor tissue. The preferred linking units guarantee the serum stability o f the conjugate of cytostatic and .alpha.~v.beta.~3 integrin antagonist and, a t the same time, the desired intracellular action within tumour cells as a result of its specific enzymatic or hydrolytic cleavability with release of the cytostatic. Formulae (II, III, IV).

Methods of integrating multiple management domains

An integrated solution strategy that integrates multiple domains together in a seamless and standardized way for increasing a users control over facilities and equipment. This integrated approach can lead to a reduction of energy usage, more efficient energy usage, increased safety, health, and security of a facility and its occupants, optimized production in industrial settings, and associated and other economic advantages. Accurate, reliable information about a facility or equipment is essential to making timely, informed decisions. Enhanced automation provides a reliable means of collecting and assembling a variety of operating data and archiving that data into a central database for evaluation, reporting, forecasting, and negotiation with resource marketers.