01-07-2021 дата публикации
Номер: US20210196808A1
The present disclosure relates to an immunogenic agent comprising Dna J heat shock protein family (Hsp40) member B7 or an immunogenic fragment thereof; a DNA vaccine comprising a nucleic acid encoding said protein or at least one immunogenic fragment thereof; a pharmaceutical composition or vector or DNA vaccine for use in the treatment of cancer; and a method of treating cancer comprising the use of said immunogenic agent or pharmaceutical composition or vector or DNA vaccine. 1. An immunogenic agent for use as a cancer vaccine comprising or consisting of DnaJ heat shock protein family (Hsp40) member B7 (termed DNAJB7) or at least one immunogenic fragment thereof.2. The immunogenic agent wherein DNAJB7 is human DNAJB7.3. The immunogenic agent according to wherein DNAJB7 is represented by the amino acid sequence set forth in SEQ ID NO: 31 or a sequence having at least 85% claim 2 , 86% claim 2 , 87% claim 2 , 88% claim 2 , 89% claim 2 , 90% claim 2 , 91% claim 2 , 92% claim 2 , 93% claim 2 , 94% claim 2 , 95% claim 2 , 96% claim 2 , 97% claim 2 , 98% or 99% identity therewith.4. The immunogenic agent according to claim 1 , wherein said at least one fragment is 5-30 amino acids in length.7. A vector or DNA vaccine comprising a nucleic acid molecule encoding a DnaJ heat shock protein family (Hsp40) member B7 (termed DNAJB7) claim 1 , or at least one immunogenic fragment thereof claim 1 , according to .8. The vector or DNA vaccine according to wherein said nucleic acid molecule is part of claim 7 , or provided in claim 7 , an expression vector adapted to express said DNAJB7 claim 7 , or at least one of said fragments thereof.9. The vector or DNA vaccine according to wherein said adaptation includes the provision of at least one transcription control sequences which mediate(s) said expression.10. The vector or DNA vaccine according to wherein the at least one transcription control sequence(s) is/are cell/tissue specific and adapted for inducible or constitutive ...
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