PREIMPREGNATE SETTING INCLUDING/UNDERSTANDING A COVERED POLYMERIC METAL SHEET HAS OPEN STRUCTURE

Un pré-imprégné durcissable comprenant une couche de fibres conductrices structurelles et une résine thermodurcissable et comprenant une feuille polymère revêtue de métal à structure ouverte.

PROCESS Of ELECTROLYSIS

Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

A salt-free emulsion for the treatment of dry eye and other ocular conditions is disclosed which contains castor oil and does not contain olive oil which prolongs TBUT and provides superior comfort.

Card Guide And Cap Antenna Retention System

Embodiments of the present invention relate to a structure and method for providing better antenna element retention in the any environment. The structure may comprise at least two card guides attached to a base. Each card guide may have at least one antenna slot, and individual antenna elements may be guided into position by an antenna slot of two different card guides. The individual antenna elements may have their freedom of motion restricted in the direction of their insertion by caps attached to the card guides. The individual antenna elements may have their freedom of motion restricted in a direction transverse to their direction of insertion by retention members attached to the card guides. By allowing for the “top-down” assembly of individual antenna elements in a modular fashion, embodiments of the present invention may facilitate easier repair of antenna element arrays, than prior art array assemblies.

Benzothiazole and related compounds

Disclosed are compounds that promote spinogenesis, are capable of reducing the neural toxicity of beta-amyloid peptides, and/or reduce the symptoms of traumatic brain injury in a patient.

Soft-Tissue Treatment With Negative Pressure

An apparatus for promoting circulation through a subcutaneous lymph vascular network may comprise a first manifold layer, a second manifold layer coupled to the first manifold layer, and a cover layer coupled to the second manifold layer. The first manifold may have a first stiffness, and the second manifold may have a second stiffness greater than the first stiffness. In some embodiments, the apparatus may additionally have a fluid interface configured to fluidly couple at least one of the first manifold layer and the second manifold layer to a fluid conductor through the cover layer. The fluid conductor may be coupled to or configured to be coupled to a source of negative pressure.

Compositions for the treatment of dry eye

The present invention relates to ophthalmic compositions and methods useful to treat dry eye, or to diagnose, cure, mitigate, treat, or prevent dry eye syndrome in man or other animals.

Light emission reducing compounds for electronic devices

A light-absorbing, neutral density filter for an electronic device display. More specifically, a light-absorbing, neutral density filter applied as a shield, protective film, or protective coating layer for an electronic device display that blocks ultraviolet light, high energy visible light, and at least a portion of blue light. The neutral density filter comprises a polymer substrate and an absorbing agent.

Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3)pyridazine-3-carboxamide

The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

Apparatus and method for quantum processing

The present disclosure provides a quantum processor realised in a semiconductor material and method to operate the quantum processor to implement error corrected quantum computation. The quantum processor comprises a plurality of qubit elements disposed in a two-dimensional matrix arrangement. The qubits are implemented using the nuclear or electron spin of phosphorus donor atoms. Further, the processor comprises a control structure with a plurality of control members, each arranged to control a plurality of qubits disposed along a line or a column of the matrix. The control structure is controllable to perform topological quantum error corrected computation.

Reduced-pressure dressings employing tissue-fixation elements

A reduced-pressure system for treating a tissue site on a patient includes a distribution manifold that adheres to a tissue site to allow retention without external support. The distribution manifold includes a porous member and a tissue-fixation element. The tissue-fixation element maintains the porous member substantially adjacent to the tissue site while a sealing member is applied. In one instance, the tissue-fixation element is a soluble adhesive that partially covers either the tissue-facing side of the porous member or a tissue-facing side of a fluid-permeable substrate layer that is on the tissue-facing side of the porous member. Other systems, distributions manifolds, and methods are presented.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Replaceable Dressing And Method For Viewing A Tissue Site

Provided are systems, dressings, and methods suitable for treating a tissue site, such as an incision or linear wound. The systems, dressings, and methods relate to a dressing assembly that may include a dressing bolster, sealing members that cover the tissue site and contain the dressing bolster, and a dressing attachment device. The dressing assembly also includes a base layer comprising a sealing member and a base attachment device for releasably coupling the base layer to the epidermis, wherein the dressing attachment device that may releasably coupled to the sealing member base layer. The dressing assembly may also include sealing ring that may be adapted to provide a fluid seal around the tissue site, and to absorb fluids from the tissue site. Other systems, apparatuses, and methods are disclosed.

Light emission reducing compounds for electronic devices

Double-notch filters for electronic devices are provided that filter light from both the blue spectrum as well as the red spectrum in narrow wavelength bands, or “notches.” A double-notch filter can, using input light from a conventional LED-backlit LCD display, output light that can be measured as substantially satisfying criteria for a D65 white point. In some examples, a double-notch filter can output light that can be measured as nearly satisfying criteria for a D65 white point, to within +/− 500 Kelvin. In some examples, a double-notch filter can output light that can be measured as nearly satisfying criteria for a D65 white point, to within +/− 1000 Kelvin.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Reduced-Pressure Dressings, Systems, And Methods For Use With Linear Wounds

Systems, methods, and dressings for treating a linear wound, such as an incision, on a patient are presented. The systems, dressings, and methods include a sealing ring that helps form a fluid seal around the linear wound. In one instance, a sealing material is extruded around the linear wound to help form a seal. In another instance, a sealing ring is coupled to a lower portion of a dressing bolster to form a seal. Other systems, methods, and apparatuses are disclosed.

Negative-pressure treatment with area stabilization

An apparatus for applying negative pressure to a tissue site proximate a patient's foot may include a tissue interface, a sole, a toe box, a cover, and an interface. The tissue interface may be configured to be circumferentially disposed around the tissue site. The sole may be configured to support the tissue interface. The toe box may be coupled to the sole. The cover may be configured to be coupled to the leg and to the sole to cover the tissue interface. The cover and the sole may form a chamber containing the tissue interface and may seal the tissue interface within the chamber. The interface may be configured to fluidly couple the tissue interface to a source of negative pressure, which can be delivered to the tissue interface for distribution to the tissue site.

Reduced-pressure dressings employing tissue-fixation elements

A reduced-pressure system for treating a tissue site on a patient includes a distribution manifold that adheres to a tissue site to allow retention without external support. The distribution manifold includes a porous member and a tissue-fixation element. The tissue-fixation element maintains the porous member substantially adjacent to the tissue site while a sealing member is applied. In one instance, the tissue-fixation element is a soluble adhesive that partially covers either the tissue-facing side of the porous member or a tissue-facing side of a fluid-permeable substrate layer that is on the tissue-facing side of the porous member. Other systems, distributions manifolds, and methods are presented.

K-mer based strain typing

At least one of the disclosed embodiments describes a computer system that enables efficient strain typing by comparing strain k-mer profiles to generate a strain typing relationship mapping. The system may include one or more processors, and one or more hardware storage devices with stored computer-executable instructions. The instructions may cause the computer system to receive a set of nucleotide sequence data. The nucleotide sequence data may include a plurality of nucleotide sequence data structures each corresponding to a separate microbial strain to be analyzed. For each nucleotide sequence data structure, a k-mer profile may be generated. K-mer profiles may be compared to determine a similarity score between the k-mer profiles, which may indicate a relationship mapping of the respective microbial strains corresponding to the k-mer profiles.

Dunnage conversion machine, method and dunnage product

Fuel injection nozzle

A polymer composition having reduced block and increased slip

Dressing interface with moisture controlling feature and sealing function

Provided are systems, dressings, and methods suitable for treating a tissue site, such as an incision or linear wound. The systems, dressings, and methods relate to a dressing assembly that may include a dressing bolster and a sealing ring. The sealing ring may be adapted to provide a fluid seal around the tissue site, and to absorb fluids from the tissue site. In some embodiments, the sealing ring may be extruded around the tissue site. In other embodiments, the sealing ring may be coupled to the dressing bolster. Other systems, apparatuses, and methods are disclosed.

Negative-pressure dressing with preferental lateral contraction

Some embodiments of a manifold pad may be configured to distribute reduced pressure relative to a tissue site and to provide a lateral contractive force relative to the tissue site. In some embodiments, the manifold pad may comprise a foam having a cell-structure forming ovoidal or ellipsoidal pores. In some embodiments, the manifold pad may be configured to preferentially contract radially or laterally upon application of negative pressure. For example, the manifold pad may be configured to be more resistant to collapse of the thickness of the manifold pad than to collapse radially or laterally. Other apparatus, dressings, systems, and methods are disclosed.

Biobased deicing/anti-icing fluids

A nontoxic deicing/anti-icing fluid includes a biobased freezing point depressant, a surfactant, an antioxidant, and water. The fluid has an LD 50 greater than about 10,000 mg/L. Another deicing/anti-icing fluid includes a biobased freezing point depressant, a vinylpyrrolidone polymer having a molecular weight between about 10,000 and about 700,000, and water. Another deicing/anti-icing fluid includes a biobased freezing point depressant, a nonionic surfactant selected from the polyoxyalkylene ethers, an antioxidant, and water. Another deicing/anti-icing fluid includes a biobased freezing point depressant, a surfactant, a food grade material that functions as an antioxidant, and water. A further deicing/anti-icing fluid includes a biobased freezing point depressant, a material that functions as both a buffer and a freezing point depressant, and water.

Deicing/anti-icing fluids

A nontoxic deicing/anti-icing fluid includes a freezing point depressant selected from short chain polyols having 3 to 5 carbons atoms, and mixtures thereof, a wetting agent, an antioxidant/preservative, and water. The fluid has an LD 50 greater than about 10,000 mg/L. Another deicing/anti-icing fluid includes the freezing point depressant, a vinylpyrrolidone polymer having a molecular weight between about 10,000 and about 700,000, and water. A runway deicing fluid includes glycerol, a buffer, an antioxidant/preservative, and water. Another deicing/anti-icing fluid includes a freezing point depressant having hydrophobic character, a wetting agent comprising an organophosphorus compound capable of producing an organic wettable surface, and water.

Light emission reducing compounds for electronic devices

Double-notch filters for electronic devices are provided that filter light from both the blue spectrum as well as the red spectrum in narrow wavelength bands, or “notches.” A double-notch filter can, using input light from a conventional LED-backlit LCD display, output light that can be measured as substantially satisfying criteria for a D65 white point. In some examples, a double-notch filter can output light that can be measured as nearly satisfying criteria for a D65 white point, to within +/− 500 Kelvin. In some examples, a double-notch filter can output light that can be measured as nearly satisfying criteria for a D65 white point, to within +/− 1000 Kelvin.

Light emission reducing compounds for electronic devices

A light-absorbing, neutral density filter for an electronic device display. More specifically, a light-absorbing, neutral density filter applied as a shield, protective film, or protective coating layer for an electronic device display that blocks ultraviolet light, high energy visible light, and at least a portion of blue light. The neutral density filter comprises a polymer substrate and an absorbing agent.

Negative-pressure treatment with area stabilization

An apparatus for applying negative pressure to a tissue site of a patient may include a tissue interface, a cover, an aperture in the cover, and a sealing member. The tissue interface may have an anatomical shape configured to cover the tissue site. The cover may be configured to cover the tissue interface. The aperture in the cover may be fluidly coupled to the tissue interface. The sealing member may be configured to seal the cover to the patient, wherein the cover and the sealing member are configured to cooperate to form a sealed chamber containing the tissue interface. The tissue interface may be coupled to a source of negative pressure, which can be delivered to the tissue interface for distribution to the tissue site. The source of negative pressure may be coupled to the cover of the apparatus.

Negative-pressure treatment with area stabilization

An apparatus for applying negative pressure to a tissue site proximate a patient's foot may include a tissue interface, a sole, a toe box, a cover, and an interface. The tissue interface may be configured to be circumferentially disposed around the tissue site. The sole may be configured to support the tissue interface. The toe box may be coupled to the sole. The cover may be configured to be coupled to the leg and to the sole to cover the tissue interface. The cover and the sole may form a chamber containing the tissue interface and may seal the tissue interface within the chamber. The interface may be configured to fluidly couple the tissue interface to a source of negative pressure, which can be delivered to the tissue interface for distribution to the tissue site.

Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Provided herein are low salt ophthalmic pharmaceutical composition and methods of use thereof, for example, in the treatment of dry eye syndrome.

Compositions for the treatment of dry eye

The present invention relates to ophthalmic compositions and methods useful to treat dry eye, or to diagnose, cure, mitigate, treat, or prevent dry eye syndrome in man or other animals.

Efficient lipid delivery to human tear film using a salt-sensitive emulsion system

Provided herein are low salt ophthalmic pharmaceutical composition and methods of use thereof, for example, in the treatment of dry eye syndrome.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and eye treatment methods

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/ort he adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions and methods to treat the eyes

Una composición oftálmica que comprende: un componente vehicular acuoso; un componente de tonicidad que comprende eritritol y carnitina; y un componente polianiónico que comprende carboximetil celulosa; mediante lo cual la osmolalidad de la composición está en el intervalo supra-tónico de 300-1.000 mOsmoles/kg. An ophthalmic composition comprising: an aqueous vehicular component; a tonicity component comprising erythritol and carnitine; and a polyanionic component comprising carboxymethyl cellulose; whereby the osmolality of the composition is in the supra-tonic range of 300-1,000 mOsmoles / kg.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Opthalmic compositions and methods for treating eyes

C.\RPonblDCC\GRSW3H7989_I DOC8/06/2012 OPHTHALMIC COMPOSITIONS AND METHODS FOR TREATING EYES Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions useful for improving visual acuity

The present invention provides a method of improving the visual acuity of a person in need thereof which comprises topically administering to said person, in an effective amount, an ophthalmic composition comprising an aqueous carrier component; and an effective amount of a tonicity component comprising a material selected from a combination of compatible solute agents, wherein said combination of compatible solute agents comprises two polyol components and one amino acid component and wherein said polyol components are erythritol and glycerol and said amino acid component is carnitine.

Compositions for the treatment of dry eye

The present invention relates to ophthalmic compositions and methods useful to treat dry eye, or to diagnose, cure, mitigate, treat, or prevent dry eye syndrome in man or other animals.

Ophthalmic compositions useful for improving visual acuity

The present invention provides a method of improving the visual acuity of a person in need thereof which comprises topically administering to said person, in an effective amount, an ophthalmic composition comprising an aqueous carrier component; and an effective amount of a tonicity component comprising a material selected from a combination of compatible solute agents, wherein said combination of compatible solute agents comprises two polyol components and one amino acid component and wherein said polyol components are erythritol and glycerol and said amino acid component is carnitine.

Compositions for the treatment of dry eye

The present invention relates to ophthalmic compositions and methods useful to treat dry eye, or to diagnose, cure, mitigate, treat, or prevent dry eye syndrome in man or other animals.

Compositions for the treatment of dry eye

The present invention relates to ophthalmic compositions and methods useful to treat dry eye, or to diagnose, cure, mitigate, treat, or prevent dry eye syndrome in man or other animals.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

topical ophthalmic compositions for treating dry eye and their uses

A presente invenção refere-se a composições oftálmicas incluindo componentes solutos compatíveis e/ou componentes polianiônicos que são utilizáveis no tratamento dos olhos, por exemplo, para aliviar a síndrome de olhos secos, para proteger os olhos contra insulto hipertônico e/ou efeitos adversos de espécies catiônicas nas superfícies oculares dos olhos e/ou para facilitar a recuperação de cirurgia no olho. The present invention relates to ophthalmic compositions including compatible solute components and / or polyanionic components that are usable in the treatment of the eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and / or adverse effects of cationic species on the ocular surfaces of the eyes and / or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Opthalmic compositions and methods for treating eyes

OPHTHALMIC COMPOSITIONS AND METHODS FOR TREATING EYES Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and eye treatment methods

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions and methods for treating eyes

Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/ort he adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.

Ophthalmic compositions and methods to treat the eyes

Una composición oftálmica que comprende: un componente vehicular acuoso; y un componente de tonicidad que comprende un material seleccionado de: componentes de eritritol y mezclas de los mismos componentes de xilitol y mezclas de los mismos; o componentes de carnitina y mezclas de los mismos. An ophthalmic composition comprising: an aqueous vehicular component; and a tonicity component comprising a material selected from: erythritol components and mixtures of the same xylitol components and mixtures thereof; or carnitine components and mixtures thereof.

Ophthalmic compositions and methods for treating eyes

Artificial tears comprising sodium hyaluronate and carboxymethylcellulose

Embodiments described herein relate to formulations for and methods of use for eye drop formulations comprising carboxymethyl cellulose (CMC) and hyaluronic acid (HA) with an improved distribution on the cornea during blinking.

Cell culture method for mesenchymal stem cells

The present disclosure relates to methods, cell culture medium and compositions that promote cell proliferation during fetal bovine serum free cell culture.

Cell culture method for mesenchymal stem cells

The present disclosure relates to methods, cell culture medium and compositions that promote cell proliferation during fetal bovine serum free cell culture.

Gas turbine engine casing

A composite casing for a gas turbine engine comprises an inner wall which may be an integrally formed drum or a plurality of separate rings, and which is overwound with carbon fibers in a cross-weave and resin bonded to the inner wall. Honeycomb material is used to increase the outside diameter of the inner wall to provide continuous surface over which to wind the fibers.

Feedstock composition and method of using same for powder metallurgy forming of reactive metals

A feedstock composition and a method of forming metal articles using powder metallurgy techniques comprise mixing metal or metal compounds powders and a novel aromatic binder system. The composition of the novel feedstock comprises an aromatic binder system and a metal powder. The aromatic binder system comprises an aromatic species and can further comprise lubricants, surfactants, and polymers as additives. The metal powder comprises elemental metals, metal compounds, and metal alloys, particularly for highly-­reactive metals. The method of forming metal articles comprises the steps of providing and mixing the metal powder and the aromatic binder system to produce a novel feedstock. The method further comprises processing the novel feedstock into a metal article using a powder metallurgy forming technique such as metal injection moulding. Metal articles formed using the present invention have an increase in carbon and oxygen contents each less than or equal to 0.2 wt% relative to the metal powder used to fabricate the article.

Feedstock composition and method of using same for powder metallurgy forming a reactive metals

A feedstock composition and a method of forming metal articles using powder metallurgy techniques comprise mixing metal powders and a novel aromatic binder system. The composition of the novel feedstock comprises an aromatic binder system and a metal powder. The aromatic binder system comprises an aromatic species and can further comprise lubricants, surfactants, and polymers as additives. The metal powder comprises elemental metals, metal compounds, and metal alloys, particularly for highly-reactive metals. The method of forming metal articles comprises the steps of providing and mixing the metal powder and the aromatic binder system to produce a novel feedstock. The method further comprises processing the novel feedstock into a metal article using a powder metallurgy forming technique. Metal articles formed using the present invention have an increase in carbon and oxygen contents each less than or equal to 0.2 wt % relative to the metal powder used to fabricate the article.

2D-coil collision sensor system

A collision sensing system for a vehicle ( 10 ) includes a two-dimensional coil sensor ( 14 ) that is attached to a vehicle structure ( 19 ) A controller ( 20 ) is in communication with the two-dimensional coil sensor ( 14 ) and detects a collision event in response to movement of the vehicle structure ( 19 ) relative to a conductive member ( 98 ) of the vehicle ( 10 ). A collision detection and safety countermeasure system ( 12 ) for a vehicle ( 10 ) includes a coil sensor ( 14 ) that is adhered to a vehicle structure ( 19 ). A controller ( 20 ) is in communication with the coil sensor ( 14 ) and generates a countermeasure signal in response to movement by the vehicle structure ( 19 ) relative to a conductive member ( 98 ) of the vehicle ( 10 ).

System and method for collecting exudates

A reduced pressure treatment system includes a porous pad positioned at a tissue site and a canister having a collection chamber, an inlet, and an outlet. The inlet is fluidly connected to the porous pad. A reduced pressure source is fluidly connected to the outlet of the canister to such that fluid from the tissue site may be drawn into the collection chamber. A hydrophobic filter is positioned adjacent the outlet to prevent liquid from exiting the collection chamber through the outlet. A baffle is positioned within the canister to create a tortuous path between the inlet and the outlet to prevent premature blocking of the hydrophobic filter.

Substitued 4-amino-1h-imidazo[4,5-c]quinoline compounds and improved methods for their preparation

Improved methods and intermediates thereof for preparing substituted 4-amino-1H-imidazo[4,5-c]quinoline compounds are described. These compounds are useful as NLRP3 modulators.

Turbine rotor emergency braking device

The device prevents overspeeding of the turbine rotor of a gas turbine drive, in case of breakage of the shaft which connects the turbine rotor to the compressor rotor. The device includes a segmented guide wheel (28), downstream of a turbine rotor stage (14), which is fixed on its outer circumference against axial displacement in the down-stream direction. The guide wheel is retained on its inner circumference by a stationary retainer frame (42). The frame includes an element (44), which frees the inner ends of the guide wheel segments, when during a shaft fracture, the turbine rotor axially impacts on the retainer frame. This causes the segments to tip into the path of the rotor blades, which it obstructs to brake the rotor.

Machine and method for pharmaceutical and pharmaceutical-like product assembly

A method and apparatus for assembling a plurality of independently formed solid components is provided thereby forming a single delivery vehicle for a pharmaceutical or pharmaceutical-like product. The solid components can be held and fed to the apparatus via a plurality of magazines. Pusher rods and the like can be used for positioning each of the solid components. Where the components are connected via a bonding liquid, a sprayer is provided and compression pins or the like press the components with the bonding liquid together to form the final product. A rivet or other connection structure can also be used and driven through holes in each of the solid components to form the final product.

methods of diagnosis and treatment of dry eye syndrome and compositions for treating a human eye

  A presente invenção refere-se a composições oculares para o tratamento do olho seco, a métodos de fabricação dessas composições e a conjuntos compreendendo uma pluralidade de diferentes composições oculares, cada uma tendo uma composição definida. Em exemplos preferidos, a invenção refere-se a composições compreendendo pelo menos um óleo natural, em que um primeiro elemento do conjunto de composições é eficaz no tratamento do olho seco em um primeiro paciente com um conjunto particular de sintomas, e um segundo elemento do conjunto de composições é eficaz no tratamento do olho seco em um segundo paciente com um conjunto diferente de sintomas. A invenção também se refere a métodos de fabricação e ao uso das composições, e a composições de cuidados da pele para uso em torno dos olhos, como as pálpebras superior e inferior, com um lubrificante, composição de base não irritante compreendendo pelo menos um óleo natural.   The present invention relates to ocular compositions for the treatment of dry eye, to methods of making such compositions and to assemblies comprising a plurality of different ocular compositions, each having a defined composition. In preferred examples, the invention relates to compositions comprising at least one natural oil, wherein a first element of the set of compositions is effective in treating dry eye in a first patient with a particular set of symptoms, and a second element of the set of compositions is effective in treating dry eye in a second patient with a different set of symptoms. The invention also relates to manufacturing methods and the use of the compositions, and to skin care compositions for use around the eyes, such as the upper and lower eyelids, with a lubricant, non-irritating base composition comprising at least one oil Natural.

Deicing/anti-icing fluids

A runway deicing fluid comprising: glycerol; a buffer; an antioxidant/preservative; and water.

Biobased deicing/anti-icing fluids

A nontoxic deicing/anti-icing fluid includes a biobased freezing point depressant, a surfactant, an antioxidant, and water. The fluid has an LD50 greater an about 10,000 mg/L. Another deicing/anti-icing fluid includes a biobased freezing point depressant, a vinylpyrrolidone polymer having a molecular weight between about 10,000 and about 700,000, and water. Another deicing/anti-icing fluid includes a biobased freezing point depressant, a nonionic surfactant selected from the polyoxyalkylene ethers, an antioxidant, and water. Another deicing/anti-icing fluid includes a biobased freezing point depressant, a surfactant, a food grade material that functions as an antioxidant, and water. A further deicing/anti-icing fluid includes a biobased freezing point depressant, a material that functions as both a buffer and a freezing point depressant, and water.

High temperature switch apparatus

Methods of diagnosing and treating dry eye syndrome and compositions for treating a human eye

In preferred the invention is directed to ocular compositions for the treatment of dry eye, methods for making such compositions, and suites comprising a plurality of different ocular compositions each having a defined composition. In preferred examples, the invention is directed to compositions comprising at least one natural oil, wherein a first member of the suite of compositions is effective in treating dry in in a first patient having a particular set of symptoms and a different second member of the suite of compositions is effective in treating dry in in a second patient having a different set of symptoms. The invention is also directed to methods of making and using the compositions, and to skin care compositions for use around the eye, such as the upper and lower eyelids having a lubricating, non-irritating base composition comprising at least one natural oil.

Epidermal harvester with integrated mechanical stretching mechanism

A device for generating skin grafts is disclosed, which includes a harvester having a distal end for placement on or in proximity of a portion of a subject's skin, where the harvester includes an orifice plate coupled to the distal end and having one or more openings. The device further includes a lid that is configured for attachment to the harvester to form a chamber and is configured for coupling to a vacuum source for generating a negative pressure in said chamber, thereby raising at least one blister through said at least one opening of the orifice plate. A skin-stretching mechanism is coupled to the harvester for stretching said skin portion so as to facilitate formation of said at least one blister. The harvester further includes a cutter integrated therein for cutting the blister. In some embodiments, the skin-stretching mechanism is coupled to the distal end of the harvester.

Potency assay

The present invention relates to a method for determining the biological activity or therapeutic efficacy of cultured mesenchymal lineage precursor cells or stem cells the based on their released TGF-9 levels in culture. The present invention also relates to isolated populations of mesenchymal lineage precursor cells or stem cells selected based on the level of TGF-9 levels released by such cells in culture. The present invention further relates to treatment of a subject suffering from a degenerative disc disease by administering such selected cell populations.

Machine and Method for Pharmaceutical and Pharmaceutical-Like Product Assembly

A method and apparatus for assembling a plurality of independently formed solid components is provided thereby forming a single delivery vehicle for a pharmaceutical or pharmaceutical-like product. The solid components can be held and fed to the apparatus via a plurality of magazines. Pusher rods and the like can be used for positioning each of the solid components. Where the components are connected via a bonding liquid, a sprayer is provided and compression pins or the like press the components with the bonding liquid together to form the final product. A rivet or other connection structure can also be used and driven through holes in each of the solid components to form the final product.

Improved stem cell composition

The disclosure provides stem cells which express high levels of Angeopoetin-1 (Ang1) and methods for their production. Such stem cells may be used in a range of therapeutic applications.

Detection of microorganisms

A method and kit for detecting micro-organisms in a mass or liquid or on a surface. The method is conducted by obtaining a sample and within a sterile chamber of limited volumetric capacity placing the sample in contact with a composition adapted to detect micro-organisms. The sterile chamber may contain a filter for isolating any micro-organisms present in the sample. Sterile sampling instruments, a delineating instrument and means for typing the micro-organisms may also be provided.

Dunnage conversion machine, method and dunnage product

A dunnage conversion machine is characterized by a forming assembly which causes lateral edge portions of a substantially continuous sheet stock material to crumple and to fold upon themselves, leaving an unfolded central portion between the laterally spaced apart folded portions. The layers of sheet stock material in the folded portions are fixed by a feeding/fixing assembly having two pairs of laterally spaced feed assemblies to form a dunnage product which does not come apart as it is manipulated. A severing assembly severs discrete dunnage products from the continuous strip of dunnage.

Detection of haematopoietic stem cells and progeny and uses thereof

The present invention relates to a method of identifying a haematopoietic stem cell (HSC) or progeny thereof comprising the steps of: obtaining a cell sample including HSC or progeny thereof; detecting the presence of at least one carbohydrate sequence having a sequence of at least one disaccharide repeat of glucuronic acid and N-acetylglucosamine or an equivalent thereof; and identifying a HSC or progeny thereof having the sequence or equivalent thereof. The invention also relates to methods of enriching cell populations for HSC or progeny thereof, for isolating HSC or progeny thereof and cell preparations obtained using the methods of their invention and their uses.

Composite materials and method of making

A method for forming improved composite materials using a thermosetting polyester urethane hybrid resin, a closed cavity mold having an internal heat transfer mechanism used in this method, and the composite materials formed by this method having a hybrid of a carbon fiber layer and a fiberglass layer.

Motor vehicle electrically heated windshield and backlight system

A system is described for electrically heating a motor vehicle windshield and backlight. The system includes a windshield having at least two conductive surfaces and a backlight having at least one conductive surface. Each of the conductive surfaces is provided with a pair of bus bars spaced from one another to permit flow of electrical charge therebetween via the conductive surfaces. This generates heat in the windshield and backlight for defogging and defrosting purposes. The system includes a three phase alternator having the conductive surfaces of the windshield and backlight connected thereto to provide substantially balanced loading of the alternator phases. The alternator may have a field winding supplied by a dc source of electrical energy located in the motor vehicle. A switch connected in series with the field winding may be provided to energize the system. Over-temperature protection for the alternator may be achieved by the provision of a thermostat also connected in series with the alternator field winding.

One piece diaphragm

Illustrative embodiments of diaphragm assemblies for diaphragm pumps and methods for manufacturing such diaphragm assemblies are disclosed. In at least one illustrative embodiment, a diaphragm pump may include an inflexible central core and a flexible diaphragm body surrounding the inflexible central core. The inflexible central core may include a reinforced thermoplastic and the flexible diaphragm body may include a thermoplastic elastomer. The flexible diaphragm body is bonded directly to the inflexible central core. The diaphragm assembly may include a mounting bolt having a head end and a threaded end. The inflexible central core surrounds the head end of the mounting bolt and the threaded end of the mounting bolt extends outside of the inflexible central core. The inflexible central core may include multiple raised features that cooperate to define cavities in the inflexible central core. The flexible diaphragm body fills the cavities of the inflexible central core.

Artificial tears comprising sodium hyaluronate and carboxymethylcellulose

Embodiments described herein relate to formulations for and methods of use for eye drop formulations comprising carboxymethyl cellulose (CMC) and hyaluronic acid (HA) with an improved distribution on the cornea during blinking.

Soft-tissue treatment with negative pressure

An apparatus for promoting circulation through a subcutaneous lymph vascular network may comprise a first manifold layer, a second manifold layer coupled to the first manifold layer, and a cover layer coupled to the second manifold layer. The first manifold may have a first stiffness, and the second manifold may have a second stiffness greater than the first stiffness. In some embodiments, the apparatus may additionally have a fluid interface configured to fluidly couple at least one of the first manifold layer and the second manifold layer to a fluid conductor through the cover layer. The fluid conductor may be coupled to or configured to be coupled to a source of negative pressure.

A quantum processor

Light emission modification

A display device is disclosed that includes a backlight comprising light-emitting diodes. The disclosed display device includes a liquid crystal panel configured to control transmission of light from the backlight to a viewer. The display device also includes one or more optical films that incorporate one or more light conversion materials.

Biobased deicing/anti-icing fluids

A nontoxic deicing/anti-icing fluid includes a biobased freezing point depressant, a surfactant, an antioxidant, and water. The fluid has an LD50 greater than about 10,000 mg/L. Another deicing/anti-icing fluid includes a biobased freezing point depressant, a vinylpyrrolidone polymer having a molecular weight between about 10,000 and about 700,000, and water. Another deicing/anti-icing fluid includes a biobased freezing point depressant, a nonionic surfactant selected from the polyoxyalkylene ethers, an antioxidant, and water. Another deicing/anti-icing fluid includes a biobased freezing point depressant, a surfactant, a food grade material that functions as an antioxidant, and water. A further deicing/anti-icing fluid includes a biobased freezing point depressant, a material that functions as both a buffer and a freezing point depressant, and water.

Treatment of immune disorders

Expansion of hematopoietic stem cells

The present disclosure relates to methods and compositions for expansion of human hematopoietic stem cells. The present disclosure also relates to methods of treatment involving the use of the expanded HSCs.

Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3)pyridazine-3-carboxamide

The invention relates to an improved process for synthesizing 6-(cyciopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula:Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

One piece diaphragm

Illustrative embodiments of diaphragm assemblies for diaphragm pumps and methods for manufacturing such diaphragm assemblies are disclosed. In at least one illustrative embodiment, a diaphragm pump may include an inflexible central core and a flexible diaphragm body surrounding the inflexible central core. The inflexible central core may include a reinforced thermoplastic and the flexible diaphragm body may include a thermoplastic elastomer. The flexible diaphragm body is bonded directly to the inflexible central core. The diaphragm assembly may include a mounting bolt having a head end and a threaded end. The inflexible central core surrounds the head end of the mounting bolt and the threaded end of the mounting bolt extends outside of the inflexible central core. The inflexible central core may include multiple raised features that cooperate to define cavities in the inflexible central core. The flexible diaphragm body fills the cavities of the inflexible central core.