09-02-2017 дата публикации
Номер: US20170037234A1
Автор:
Robert K. PRUD'HOMME,
Rodney D. PRIESTLEY,
Rui LIU,
Chris SOSA,
PRUD'HOMME ROBERT K,
PRIESTLEY RODNEY D,
LIU RUI,
SOSA CHRIS,
PRUD'HOMME Robert K.,
PRIESTLEY Rodney D.,
LIU Rui,
SOSA Chris
Polymer nanoparticles, including Janus nanoparticles, and methods of making them are described. 1. A method of forming a multi-faced polymer nanoparticle , comprisingdissolving a first polymer at a first concentration and a second polymer at a second concentration in a solvent to form a polymer solution,selecting a nonsolvent,selecting a mean nanoparticle diameter,selecting the first concentration and second concentration to achieve the selected moan nanoparticle diameter, andcontinuously mixing the polymer solution with the nonsolvent to flash precipitate the multi-faced polymer nanoparticle in a mixture of the solvent and the nonsolvent,wherein the first polymer is different from the second polymer and a first region, comprising the first polymer at a greater weight fraction than the second polymer, and', 'a second region, comprising the second polymer at a greater weight fraction than the first polymer,', 'the first region being in contact with the second region., 'wherein the multi-faced polymer nanoparticle comprises'}2. The method of claim 1 , wherein neither the polymer solution nor the nonsolvent comprise a stabilizer.3. The method of claim 1 , wherein the mixing of the polymer solution with the nonsolvent further comprises mixing with a collection solution.4. The method of claim 3 , wherein the collection solution comprises a stabilizer.5. The method of claim 4 , wherein the stabilizer is an amphiphilic surfactant molecule.6. The method of claim 4 , wherein the stabilizer is selected from the group consisting of sulfonated alkyl surfactants claim 4 , sodium dodecyl sulfate claim 4 , ethoxylated sulfonate surfactants claim 4 , cationic surfactants claim 4 , amine oxide surfactants claim 4 , zwitterionic surfactants claim 4 , amphoteric surfactants claim 4 , ethylene oxide surfactants based on alkyl ethers claim 4 , ethylene oxide surfactants based on nonylphenols claim 4 , surfactants based on sorbitan oleates claim 4 , glucose-based surfactants claim 4 , ...
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