PROCEDURE FOR THE PROOF OF PICKELN BEFORE SPROUTING

Skin barrier preparation and method therefor

A method of selecting a skin barrier system suitable for infants and young children is disclosed.

Method for measuring skin hydration

The methods of this invention relate to means for measuring skin hydration. The methods of this invention 5 utilize at least two wavelengths filtered by at least two polarizers to create digital images of skin treated with personal care products. The methods are useful for demonstrating the efficacy of skin care products intended to increase skin hydration and/or protect the 10 skin from dehydration, even when such dehydration is not apparent to the naked eye. ------ -- --- ...

SKIN BARRIER PREPARATION AND METHOD THEREFOR

CA 03086684 2020-06-22 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111 1 11111111 111111 1 11 11111 1 111 11111 1 111 1 111 1111 1111 1 111 1 111 1111 11111111111 1 111111 Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2019/135129 Al 11 July 2019 (11.07.2019) WIPO I PCT (51) International Patent Classification: G16H 50/50 (2018.01) GO1N 33/50 (2006.01) Declarations under Rule ¨ as to applicant's enti4.17: tlement to apply for and be granted a (21) International Application Number: patent (Rule 4.17(ii)) PCT/IB2018/060130 ¨ as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) (22) International Filing Date: 14 December 2018 (14.12.2018) Published: with international search report (Art. 21(3)) (25) Filing Language: Engli ¨ sh ¨ in black and white; the international application as filed (26) Publication Language: English contained color or greyscale and is available for download from PATENTSCOPE (30) Priority Data: 62/613,8'78 05 January 2018 (05.01.2018) US (71) Applicant: JOHNSON & JOHNSON CONSUMER INC. [US/US]; 199 Grandview Road, Skillman, New Jer-sey 08558 (US). (72) Inventors: BENSACI, Jalil; Johnson & Johnson France, 1 Rue Camille Desmoulins, Issy-les Moulineaux, 2'7100 Val De Reuil (FR). ODDOS, Thierry; Johnson & John-son Sante Beaute France, Campus de Maigremont, 27100 Val De Reuil (FR). STAMATAS, Georgios N.; Johnson & Johnson France, 1 Rue Camille Desmoulins, 92130 Issy-les Moulineaux (FR). = (74) Agent: SHIRTZ, Joseph F. et al.; Johnson & Johnson, One Johnson & Johnson Plaza, New Brunswick, New Jer-sey 08933 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, ...

Method for demonstrating pre-emergent pimples

METHOD FOR MEASURING SKIN HYDRATION

The methods of this invention relate to means for measuring skin hydration. The methods of this invention utilize at least two wavelengths filtered by at least two polarizers to create digital images of skin treated with personal care products. The methods are useful for demonstrating the efficacy of skin care products intended to increase skin hydration and/or protect the skin from dehydration, even when such dehydration is not apparent to the naked eye.

MILD SURFACTANT PREPARATION AND METHOD THEREFOR

A method of selecting a surfactant system suitable for infants and young children is disclosed.

Method of assessing skin and overall health of an individual

METHOD FOR DEMONSTRATING PRE-EMERGENT PIMPLES

A method for demonstrating pre-emergent pimples is disclosed. The method includes providing a camera having a 25 mm macro lens and a linear polarizing filter including from 10 to 50 narrow band filters in the spectral range of 400-970 nm, and a light source having a linear polarizer oriented vertical to a polarization plane of the camera polarizer; taking a sequence of images of the face of a subject with the camera; creating an erythema map of the imaged area using oxy-hemoglobin values at each corresponding pixel; taking a visible-light image of the face of the subject; and comparing the images to see pre-emergent pimples. The method enables consumers to see pre-emergent pimples and treat them, which results in preventing the pimples from emerging or reducing the emergence of the pimples.

METHOD FOR DEMONSTRATING PRE-EMERGENT PIMPLES

Method for demonstrating pre-emergent pimples

A method for demonstrating pre-emergent pimples is disclosed. The method includes providing a camera having a 25 mm macro lens and a linear polarizing filter including from 10 to 50 narrow band filters in the spectral range of 400-970 nm, and a light source having a linear polarizer oriented vertical to a polarization plane of the camera polarizer; taking a sequence of images of the face of a subject with the camera; creating an erythema map of the imaged area using oxy-hemoglobin values at each corresponding pixel; taking a visible-light image of the face of the subject; and comparing the images to see pre-emergent pimples. The method enables consumers to see pre-emergent pimples and treat them, which results in preventing the pimples from emerging or reducing the emergence of the pimples.

Method of assessing skin and overall health of an individual

Method of assessing skin and overall health of an individual

The present invention relates to a method of determining skin health of an area of skin and overall health of an individual by exposing the area of skin to a first exposure 5 radiation to induce the area of skin to emit a first fluorescent emission, measuring the intensity of the first fluorescent emission, exposing the area of skin to a second exposure radiation to induce the area of skin to emit a second fluorescent emission, measuring the intensity of the second fluorescent emission, calculating a ratio of these intensities, and comparing the ratio to a control ratio. Figure 1 z z - 390 u 0 240 280 320 360 400 440 480 WAVELENGTH (nm) ...

Mild surfactant preparation and method therefor

A method of selecting a surfactant system suitable for infants and young children is disclosed.

Method for demonstrating pre-emergent pimples

A method for demonstrating pre-emergent pimples is disclosed. The method includes providing a camera having a 25 mm macro lens and a linear polarizing filter including from 10 to 50 narrow band filters in the spectral range of 400-970 nm, and a light source having a linear polarizer oriented vertical to a polarization plane of the camera polarizer; taking a sequence of images of the face of a subject with the camera; creating an erythema map of the imaged area using oxy-hemoglobin values at each corresponding pixel; taking a visible-light image of the face of the subject; and comparing the images to see pre-emergent pimples. The method enables consumers to see pre-emergent pimples and treat them, which results in preventing the pimples from emerging or reducing the emergence of the pimples.

Method of assessing skin and overall health of an individual

Method for measuring skin hydration

The methods of this invention relate to means for measuring skin hydration. The methods of this invention utilize at least two wavelengths filtered by at least two polarizers to create digital images of skin treated with personal care products. The methods are useful for demonstrating the efficacy of skin care products intended to increase skin hydration and/or protect the skin from dehydration, even when such dehydration is not apparent to the naked eye.

Methods and devices for evaluating skin

Provided are methods and devices for evaluating skin by introducing a fluid comprising water to the skin; measuring at least one skin barrier property that correlates to the water content of the skin over time, the measuring step comprising taking at least one measurement of the skin barrier property in the time frame starting from completion of the introducing step up to about 60 seconds after such introducing step and optionally taking a plurality of skin barrier property measurements after about 60 seconds after completion of the introducing step; and comparing the skin water content measurements of the measuring step with at least one Comparative Data Set to determine the relative infant-like barrier properties of the skin.

Mild surfactant preparation and method therefor

A method of selecting a surfactant system suitable for infants and young children is disclosed.

METHOD FOR MEASURING SKIN HYDRATION

The methods of this invention relate to means for measuring skin hydration. The methods of this invention utilize at least two wavelengths filtered by at least two polarizers to create digital images of skin treated with personal care products. The methods are useful for demonstrating the efficacy of skin care products intended to increase skin hydration and/or protect the skin from dehydration, even when such dehydration is not apparent to the naked eye.

MILD SURFACTANT PREPARATION AND METHOD THEREFOR

A method of selecting a surfactant system suitable for infants and young children is disclosed. 1. A method of evaluating a potential impact of a surfactant system on infant skin , comprising:a) topically applying said surfactant system to adult skin;b) topically applying a marker to said surfactant system treated adult skin;c) measuring penetration of said marker into said surfactant system treated adult skin;d) using a computational model of adult skin penetration to visualize penetration of the marker by optimizing penetration parameters so that the model of adult skin penetration profiles match the experimental data;e) transferring the optimized penetration parameters to a computational model of infant skin; andf) determining the penetration of the marker in the computational model of infant skin.2. The method of claim 1 , wherein the marker is caffeine.3. The method of claim 1 , wherein the EPISIM platform is employed as the computational model of adult skin penetration.4. A surfactant system selected by the method of .5. The method of claim 1 , wherein the computational model of adult skin penetration is an agent-based model. This application claims priority of the benefits of the filing of U.S. Provisional Application Ser. No. 62/613,878, filed Jan. 5, 2018, the contents of which are hereby incorporated by reference herein in their entirety.The present invention relates to the development of mild surfactant systems, particularly for infants or young children, while assessing the level of skin irritation through analyses of adult skin tests. The invention allows one to evaluate the irritation level of a surfactant system with objective data while avoiding the need to test on young children or infants.Skin cleansers contain surfactants, which may compromise the integrity of skin barrier to the penetration of external aggressors, resulting in skin irritation. Assessing cleanser mildness on skin is typically done by clinical evaluation and measurement of ...

SKIN BARRIER PREPARATION AND METHOD THEREFOR

A method of selecting a skin barrier system suitable for infants and young children is disclosed. 1. An method of evaluating a potential impact of a barrier system on infant skin , comprising:a) topically applying said barrier system to adult skin;b) topically applying a marker to said barrier system treated adult skin;c) measuring penetration said marker into said barrier system treated adult skin;d) using a computational model of adult skin penetration to visualize penetration of the marker by optimizing penetration parameters so that the model of adult skin penetration profiles match the experimental data;e) transferring the optimized penetration parameters to a computational model of infant skin; andf) determining the penetration of the marker in the computational model of infant skin.2. The method of claim 1 , wherein the marker is caffeine.3. The method of claim 1 , wherein EPISIM is employed as the computational model of adult skin penetration.4. A barrier system selected by the method of .5. The method of claim 1 , wherein the computational model of adult skin penetration is an agent-based model. This application claims priority of the benefits of the filing of U.S. Provisional Application Ser. No. 62/613,878, filed Jan. 5, 2018, the contents of which are hereby incorporated by reference herein in their entirety.The present invention relates to the development of skin barrier systems, particularly for infants or young children, while assessing the level of skin protection through analyses of adult skin tests. The invention allows one to evaluate the protection level of a skin barrier system with objective data while avoiding the need to test on young children or infants.Skin cleansers contain surfactants, which may compromise the integrity of skin barrier to the penetration of external aggressors, resulting in skin irritation. Assessing cleanser mildness on skin is typically done by clinical evaluation and measurement of alterations in trans epidermal water ...

Method of assessing skin and overall health of an individual

The present invention relates to a method of determining skin health of an area of skin and overall health of an individual by exposing the area of skin to a first exposure radiation to induce the area of skin to emit a first fluorescent emission, measuring the intensity of the first fluorescent emission, exposing the area of skin to a second exposure radiation to induce the area of skin to emit a second fluorescent emission, measuring the intensity of the second fluorescent emission, calculating a ratio of these intensities, and comparing the ratio to a control ratio.

SKIN BARRIER PREPARATION AND METHOD THEREFOR

A method of selecting a skin barrier system suitable for infants and young children is disclosed. 1. An method of evaluating an ability of a skin barrier system to protect infant skin from external irritants , comprising:a) topically applying said barrier system to adult skin;b) topically applying an external irritant to said barrier system treated adult skin;c) observing the production of inflammatory molecules in said barrier system treated adult skin;d) using a computational model of adult skin inflammation to visualize an effect of the external irritant by optimizing inflammation parameters so that the model of adult skin inflammation profiles match the experimental data;e) transferring the optimized inflammation parameters to a computational model of infant skin; andf) determining the impact of theirritant in the computational model of infant skin.2. The method of claim 1 , wherein irritant is selected from paraffin and petrolatum.3. The method of claim 1 , wherein EPISIM is employed as the computational model of adult skin inflammation.4. A barrier system selected by the method of .5. The method of claim 1 , wherein the computational model of adult skin inflammation is an agent-based model. The present invention relates to the development of skin barrier systems, particularly for infants or young children, while assessing the level of skin protection through analyses of adult skin tests. The invention allows one to evaluate the protection level of a skin barrier system with objective data while avoiding the need to test on young children or infants.Skin cleansers contain surfactants, which may compromise the integrity of skin barrier to the penetration of external aggressors, resulting in skin irritation. Assessing cleanser mildness on skin is typically done by clinical evaluation and measurement of alterations in trans epidermal water loss (TEWL) following exaggerated patch test or exaggerated wash test protocols. These methods are partly subjective and often ...

METHOD OF ASSESSING INDIVIDUAL SKIN AND OVERALL HEALTH

PROBLEM TO BE SOLVED: To provide a method for determining skin health in an area of skin and the overall health of an individual. SOLUTION: This method comprises a process for exposing the area of skin to a first exposure radiation to induce the area of skin to emit a first fluorescent emission, a process for measuring the intensity of the first fluorescent emission, a process for exposing the area of skin to a second exposure radiation to induce the area of skin to emit a second fluorescent emission, a process for measuring the intensity of the second fluorescent emission, a process for calculating a ratio of these intensities, and a process for comparing the ratio to a control ratio. COPYRIGHT: (C)2005,JPO&NCIPI ...

METHOD FOR DEMONSTRATING PRE-EMERGENT PIMPLES

A method for demonstrating pre-emergent pimples is disclosed. The method includes providing a camera having a 25 mm macro lens and a linear polarizing filter including from 10 to 50 narrow band filters in the spectral range of 400-970 nm, and a light source having a linear polarizer oriented vertical to a polarization plane of the camera polarizer; taking a sequence of images of the face of a subject with the camera; creating an erythema map of the imaged area using oxy-hemoglobin values at each corresponding pixel; taking a visible-light image of the face of the subject; and comparing the images to see pre-emergent pimples. The method enables consumers to see pre-emergent pimples and treat them, which results in preventing the pimples from emerging or reducing the emergence of the pimples.

USE OF BIOMARKERS TO EVALUATE THE EFFICACY OF A COMPOSITION IN REDUCING THE EFFECTS OF CANCER THERAPEUTICS ON SKIN

A method to evaluate the potential of cancer therapeutics to produce skin related side effects is disclosed. The method, which involves use of biological markers, can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin. 1. An in vitro method of evaluating the efficacy of a composition in reducing the effects of a cancer therapeutic on skin , comprising:{'claim-text': ['wherein said model comprises a cancer therapeutic at an amount effective to simulate chronic drug exposure;', 'wherein said model functionally reproduces barrier compromise due to treatment with said cancer therapeutic; and', 'wherein said barrier compromise is determined by measuring a resulting biological process.'], '#text': 'employing an in vitro or ex vivo epidermal tridimensional model exhibiting differentiating keratinocytes in a reconstituted stratum corneum;'}2. The method of claim 1 , wherein the biological process is phosphorylation status of one or more proteins.3. The method of claim 2 , wherein said protein phosphorylation is up-regulated.4. The method of claim 2 , wherein said protein phosphorylation is down-regulated.5. The method of claim 1 , wherein the biological process is gene expression.6. The method of claim 5 , wherein said gene expression is up-regulated.7. The method of claim 5 , wherein said gene expression is down-regulated.8. Use of the model of to test a composition to determine if said composition can prevent the effect said cancer therapeutic has on skin barrier structure and function. This application claims priority of the benefit of the filing of U.S. Provisional Application Ser. No. 62/950,624, filed Dec. 19, 2019, the contents of which are hereby incorporated by reference herein in their entirety.The invention relates to methods to evaluate the potential of cancer therapeutics to produce skin related side effects. The present invention also relates to methods for evaluating the efficacy of a composition in ...

MICROBIOME AND METOBOLOME CLUSTERS TO EVALUATE SKIN HEALTH

A method for evaluating skin health is disclosed. The method can be used to select skin treatment regimens, ingredients and compositions. 1. A method of evaluating skin health , comprising:observing microbiome and metabolome clusters on a surface area of said skin; andassessing said skin health based on the make-up of said microbiome and metabolome clusters.2. The method of :{'i': 'Cutibacterium', 'wherein an abundance of sp. in said microbiome is an indication of a ceramide- and lipid-rich, relatively dryer and more basic environment.'}3. The method of :{'i': 'Staphylococcus', 'wherein an abundance of sp. in said microbiome is an indication of a lysine- and sugar-rich, more hydrated and acidic environment.'}4. The method of claim 1 ,{'i': 'Streptococcus', 'wherein an abundance of sp. in said microbiome is independent of the presence of any particular metabolomic profile.'}5. Use of the method of to deduce treatment benefits on skin traits claim 1 , including but not limited to skin moisturization and skin barrier function. This application claims priority to U.S. provisional patent application No. 63/110,445 the entire contents of which are incorporated by reference hereinThe present invention relates to methods for evaluating skin health. The methods may be employed to select skin treatments. The present invention also relates to methods for identifying regimens, ingredients and compositions that can improve the health of skin. It also relates to the use of such regimens, ingredients and compositions to formulate skin care products.Skin is the body's first line of defense against infections and environmental stressors. It acts as a major physical and immunological protective barrier, but also plays a critical role in temperature regulation, water holding, vitamin D production, and sensing. Its outermost surface consists of a lipid- and protein-laden cornified layer dotted with hair follicles and eccrine glands that secrete lipids, antimicrobial peptides (AMPs), ...

Method for Evaluating the Efficacy of a Composition in Reducing the Effects of Cancer Therapeutics on Skin

An epidermal tridimensional model exhibiting differentiating keratinocytes in a reconstituted stratum corneum model is disclosed. The model, which contains a cancer therapeutic at an amount effective to simulate chronic drug exposure, can be used to evaluate the potential of cancer therapeutics to produce skin related side effects. The method can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin. 1. An in vitro or ex vivo epidermal tridimensional model exhibiting differentiating keratinocytes in a reconstituted stratum corneum; wherein said model comprises a cancer therapeutic at an amount effective to simulate chronic drug exposure; and wherein said model functionally reproduces barrier compromise due to treatment with said cancer therapeutic.2. The model of claim 1 , wherein said model is a reconstructed human epidermal (RHE) model.3. The model of claim 1 , wherein skin barrier function is assessed by measuring trans-epidermal water loss (TEWL) rates on said model.4. Use of the model of to test a cancer therapeutic to determine if said cancer therapeutic produces skin related side effects.5. Use of the model of to test a composition to determine if said composition can prevent the effect said cancer therapeutic has on skin barrier structure and function.6. A method for evaluating the in vitro efficacy of a composition in reducing the effects of a cancer therapeutic on skin claim 1 , comprising using the model of . This application claims priority of the benefit of the filing of U.S. Provisional Application Ser. No. 62/950,624, filed Dec. 19, 2019, the contents of which are hereby incorporated by reference herein in their entirety.The invention relates to methods to evaluate the potential of cancer therapeutics to produce skin related side effects. The present invention also relates to methods for evaluating the efficacy of a composition in reducing the effects of cancer therapeutics on skin.Oncology ...

Method of assessing skin and overall health of an individual

The present invention relates to a method of determining skin health of an area of skin and overall health of an individual by exposing the area of skin to a first exposure radiation to induce the area of skin to emit a first fluorescent emission, measuring the intensity of the first fluorescent emission, exposing the area of skin to a second exposure radiation to induce the area of skin to emit a second fluorescent emission, measuring the intensity of the second fluorescent emission, calculating a ratio of these intensities, and comparing the ratio to a control ratio.

Skin barrier preparation and method therefor

A method of selecting a skin barrier system suitable for infants and young children is disclosed.

Method of assessing skin and overall health of an individual

The present invention relates to a method of determining skin health of an area of skin and overall health of an individual by exposing the area of skin to a first exposure radiation to induce the area of skin to emit a first fluorescent emission, measuring the intensity of the first fluorescent emission, exposing the area of skin to a second exposure radiation to induce the area of skin to emit a second fluorescent emission, measuring the intensity of the second fluorescent emission, calculating a ratio of these intensities, and comparing the ratio to a control ratio.

preparation of mild surfactant and method for it

A presente invenção refere-se a um método de seleção de um sistema tensoativo adequado para bebês e crianças pequenas. The present invention relates to a method of selecting a surfactant system suitable for babies and young children.

Method of assessing skin and overall health of an individual

The present invention relates to a method of determining skin health of an area of skin and overall health of an individual by exposing the area of skin to a first exposure radiation to induce the area of skin to emit a first fluorescent emission, measuring the intensity of the first fluorescent emission, exposing the area of skin to a second exposure radiation to induce the area of skin to emit a second fluorescent emission, measuring the intensity of the second fluorescent emission, calculating a ratio of these intensities, and comparing the ratio to a control ratio.

Biomarkers predictive of atopic dermatitis

A method to predict a propensity of an individual to develop atopic dermatitis is disclosed. The method, which involves use of biological markers, can also be used to evaluate the efficacy of a composition to treat atopic dermatitis. The markers include hBD1, IL1RA, IL36g and S100A8/9, various skin microbe species and total amino acid content.

MILD SURFACTANT PREPARATION AND METHOD FOR THE SAME

A presente invenção refere-se a um método de seleção de um sistema tensoativo adequado para bebês e crianças pequenas. The present invention relates to a method of selecting a surfactant system suitable for infants and young children.

Analysis and Characterization of Epithelial Tissue Structure

Methods for non-invasive or minimally invasive assessment of epithelial tissue structure are disclosed. Digital imaging and processing are used to identify cell locations. More specifically, an automated algorithm that may be used to identify epithelial tissue structure, and/or to specify the coordinates/locations of cells in the epithelial tissue structure, through non-invasive or minimally invasive imaging, and use of this information to extract values of epithelial structure related parameters are disclosed.

Use of microbiome and metobolome clusters to evaluate skin health

A method for evaluating skin health is disclosed. The method can be used to|select skin treatment regimens, ingredients and compositions.

Mild surfactant preparation and method therefor

A method of selecting a surfactant system suitable for infants and young children is disclosed.

Uso de biomarcadores para evaluar la eficacia de una composición en la reducción de los efectos de la terapéutica contra el cáncer en la piel.

Se describe un método para evaluar el potencial de la terapéutica contra el cáncer para producir efectos secundarios relacionados con la piel. El método, que implica el uso de marcadores biológicos, también puede usarse para evaluar la eficacia de una composición para reducir los efectos de la terapéutica contra el cáncer en la piel.

Analysis and characterization of epithelial tissue structure

Methods for non-invasive or minimally invasive assessment of epithelial tissue structure are disclosed. Digital imaging and processing are used to identify cell locations. More specifically, an automated algorithm that may be used to identify epithelial tissue structure, and/or to specify the coordinates/locations of cells in the epithelial tissue structure, through non-invasive or minimally invasive imaging, and use of this information to extract values of epithelial structure related parameters are disclosed.

Window of opportunity skin treatment regimen and composition for preventing the onset of or treating atopic dermatitis

A window of opportunity skin treatment regimen and composition for preventing the onset of or treating atopic dermatitis is disclosed.

Verfahren für den nachweis von pickeln vor dem spriessen

Use of microbiome and metobolome clusters to evaluate skin health

A method for evaluating skin health is disclosed. The method can be used to|select skin treatment regimens, ingredients and compositions.

Use of microbiome and metobolome clusters to evaluate skin health

A method for evaluating skin health is disclosed. The method can be used to|select skin treatment regimens, ingredients and compositions.

Biomarkers predictive of atopic dermatitis in infants and their use to facilitate prevention and/or treatment of atopic dermatitis

A method to predict a propensity of an infant to develop atopic dermatitis. The method includes observing the expression of S100A8/A9 on a skin area of an infant; comparing the expression to determined standard, wherein the determined standard is ascertained by measuring a level of the biomarker in a subject or pool of subjects who have demonstrated an absence of atopic dermatitis; and determining the propensity of an infant to develop atopic dermatitis, wherein an increase in the expression as compared to the determined standard indicates propensity of the infant to develop atopic dermatitis.

Analysis and characterization of epithelial tissue structure

Methods for non-invasive or minimally invasive assessment of epithelial tissue structure are disclosed. Digital imaging and processing are used to identify cell locations. More specifically, an automated algorithm that may be used to identify epithelial tissue structure, and/or to specify the coordinates/locations of cells in the epithelial tissue structure, through non-invasive or minimally invasive imaging, and use of this information to extract values of epithelial structure related parameters are disclosed.

Uso de grupos de microbioma y metoboloma para evaluar la salud de la piel.

Se describe un método para evaluar la salud de la piel. El método puede usarse para seleccionar regímenes, ingredientes y composiciones de tratamiento de la piel.

Método para evaluar la eficacia de una composición en la reducción de los efectos de la terapéutica contra el cáncer en la piel.

Se describe un modelo tridimensional epidérmico que exhibe queratinocitos de diferenciación en un modelo de estrato córneo reconstituido. El modelo, que contiene una terapéutica contra el cáncer en una cantidad efectiva para simular la exposición crónica al fármaco, puede usarse para evaluar el potencial de la terapéutica contra el cáncer para producir efectos secundarios relacionados con la piel. El método también puede usarse para evaluar la eficacia de una composición para reducir los efectos de la terapéutica contra el cáncer en la piel.

Method for evaluating the efficacy of a composition in reducing the effects of cancer therapeutics on skin

An epidermal tridimensional model exhibiting differentiating keratinocytes in a reconstituted stratum corneum model is disclosed. The model, which contains a cancer therapeutic at an amount effective to simulate chronic drug exposure, can be used to evaluate the potential of cancer therapeutics to produce skin related side effects. The method can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin.

Método para avaliação da eficácia de uma composição na redução do efeitos da terapêutica para câncer sobre a pele

MÉTODO PARA AVALIAÇÃO DA EFICÁCIA DE UMA COMPOSIÇÃO NA REDUÇÃO DO EFEITOS DA TERAPÊUTICA PARA CÂNCER SOBRE A PELE. É revelado um modelo tridimensional epidérmico que apresenta queratinócitos de diferenciação em um modelo de estrato córneo reconstituído. O modelo, que contém um agente terapêutico para câncer em uma quantidade eficaz para simular a exposição crônica ao fármaco, pode ser usado para avaliar o potencial da terapêutica para câncer para produzir efeitos colaterais relacionados à pele. O método pode também ser usado para avaliar a eficácia de uma composição na redução dos efeitos da terapêutica para câncer sobre a pele.

Method for evlauating the efficacy of composition in reducing the effects of cancer therapeutics on skin

An epidermal tridimensional model exhibiting differentiating keratinocytes in a reconstituted stratum corneum model is disclosed. The model, which contains a cancer therapeutic at an amount effective to simulate chronic drug exposure, can be used to evaluate the potential of cancer therapeutics to produce skin related side effects. The method can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin.

Method for evlauating the efficacy of composition in reducing the effects of cancer therapeutics on skin

An epidermal tridimensional model exhibiting differentiating keratinocytes in a reconstituted stratum corneum model is disclosed. The model, which contains a cancer therapeutic at an amount effective to simulate chronic drug exposure, can be used to evaluate the potential of cancer therapeutics to produce skin related side effects. The method can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin.

Method for evlauating the efficacy of composition in reducing the effects of cancer therapeutics on skin

An epidermal tridimensional model exhibiting differentiating keratinocytes in a reconstituted stratum corneum model is disclosed. The model, which contains a cancer therapeutic at an amount effective to simulate chronic drug exposure, can be used to evaluate the potential of cancer therapeutics to produce skin related side effects. The method can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin.

Skin barrier preparation and method therefor

A method of selecting a skin barrier system suitable for infants and young children is disclosed.

Use of biomarkers to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin

A method to evaluate the potential of cancer therapeutics to produce skin related side effects is disclosed. The method, which involves use of biological markers, can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin.

Uso de biomarcadores para avaliar a eficácia de uma composição na redução dos efeitos de agentes terapêuticos contra câncer sobre a pele

USO DE BIOMARCADORES PARA AVALIAR A EFICÁCIA DE UMA COMPOSIÇÃO NA REDUÇÃO DOS EFEITOS DE AGENTES TERAPÊUTICOS CONTRA CÂNCER SOBRE A PELE. É revelado um método para avaliar o potencial de agentes terapêuticos contra câncer de produzir efeitos colaterais relacionados à pele. O método, que envolve o uso de marcadores biológicos, também pode ser usado para avaliar a eficácia de uma composição na redução dos efeitos de agentes terapêuticos contra câncer na pele.

Use of biomarkers to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin

A method to evaluate the potential of cancer therapeutics to produce skin related side effects is disclosed. The method, which involves use of biological markers, can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin.

Use of biomarkers to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin

A method to evaluate the potential of cancer therapeutics to produce skin related side effects is disclosed. The method, which involves use of biological markers, can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin.

Use of biomarkers to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin

A method to evaluate the potential of cancer therapeutics to produce skin related side effects is disclosed. The method, which involves use of biological markers, can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin.

Biomarkers Predictive of Atopic Dermatitis

A method to predict a propensity of an individual to develop atopic dermatitis is disclosed. The method, which involves use of biological markers, can also be used to evaluate the efficacy of a composition to treat atopic dermatitis.

Analisis y caracterizacion de la estructura de tejido epitelial.

Se describen métodos para la evaluación no invasiva o mínimamente invasiva de la estructura de tejido epitelial. Se usan imagenología y procesamiento digital para identificar ubicaciones celulares. Más específicamente, se describen un algoritmo automatizado que puede usarse para identificar estructura de tejido epitelial y/o para especificar las coordenadas/ubicaciones de células en la estructura de tejido epitelial, a través de imagenología no invasiva o mínimamente invasiva, y uso de esta información para extraer valores de parámetros relacionados con la estructura epitelial.

Cutibacterium acnes biomimetic, prebiotic, probiotic and postbiotic compositions for treatment of skin conditions

Biomimetic, prebiotic, probiotic and postbiotic compositions and methods of use thereof are disclosed. The biomimetic, prebiotic, probiotic and postbiotic compositions may include bacteria of the genera Cutibacterium acnes (C. acnes), its culture and/or components thereof; and/or a substance that induces the growth or activity of C. acnes. The biomimetic, prebiotic, probiotic and postbiotic compositions may be used in preventing, improving and/or treating such conditions such as atopic dermatitis.

Systems and Methods for Automatic Cell Identification Using Images of Human Epithelial Tissue Structure

Systems and methods for improving the image quality of images of epithelial tissue structures are disclosed. The systems include training a first cycle-GAN model and a second cycle-GAN model simultaneously, where the first cycle-GAN model is trained to remove noise from an image and the second cycle-GAN model is trained to learn the structure of the image. Additional systems and methods include deploying the trained cycle-GAN model to identify an unknown image segment and/or generate a protocol for following the identified skin care treatment recommendation for an identified image segment.

Cutibacterium Acnes Biomimetic, Prebiotic, Probiotic and Postbiotic Compositions for Treatment of Skin Conditions

Biomimetic, prebiotic, probiotic and postbiotic compositions and methods of use thereof are disclosed. The biomimetic, prebiotic, probiotic and postbiotic compositions may include bacteria of the genera Cutibacterium acnes (C. acnes), its culture and/or components thereof; and/or a substance that induces the growth or activity of C. acnes. The biomimetic, prebiotic, probiotic and postbiotic compositions may be used in preventing, improving and/or treating such conditions such as atopic dermatitis.

Analysis and characterization of epithelial tissue structure

Methods for non-invasive or minimally invasive assessment of epithelial tissue structure are disclosed. Digital imaging and processing are used to identify cell locations. More specifically, an automated algorithm that may be used to identify epithelial tissue structure, and/or to specify the coordinates/locations of cells in the epithelial tissue structure, through non-invasive or minimally invasive imaging, and use of this information to extract values of epithelial structure related parameters are disclosed.

Mild surfactant preparation and method therefor

A method of selecting a surfactant system suitable for infants and young children is disclosed.

Biomarkers predictive of atopic dermatitis

A method to predict a propensity of an individual to develop atopic dermatitis is disclosed. The method, which involves use of biological markers, can also be used to evaluate the efficacy of a composition to treat atopic dermatitis. The markers include hBD1, IL1RA, IL36g and S100A8/9, various skin microbe species and total amino acid content.

Systems and methods for automatic cell identification using images of human epithelial tissue structure

Systems and methods for improving the image quality of images of epithelial tissue structures are disclosed. The systems include training a first cycle-GAN model and a second cycle-GAN model simultaneously, where the first cycle-GAN model is trained to remove noise from an image and the second cycle-GAN model is trained to learn the structure of the image. Additional systems and methods include deploying the trained cycle-GAN model to identify an unknown image segment and/or generate a protocol for following the identified skin care treatment recommendation for an identified image segment.

Use of microbiome and metobolome clusters to evaluate skin health

A method for evaluating skin health is disclosed. The method can be used to|select skin treatment regimens, ingredients and compositions.