26-12-2013 дата публикации
Номер: US20130345675A1
The present application relates to high flow rate isolated regional treatment of cancer and proliferative disorders and conditions. For example, provided are methods, systems and devices for treating a cancer in a region of a subject using high flow rate isolated infusion. 1. A method for treating a cancer in a region of a subject , comprising:a. percutaneuosly introducing a catheter into the vasculature of the subject;b. advancing the catheter to or in proximity to the region; andc. infusing fluid through the catheter and into the region, wherein the fluid comprises at least one therapeutic agent effective for treating the cancer, and wherein the fluid is infused into the region at a rate of 150 cc/min or higher.2. The method of claim 1 , wherein the catheter is introduced and advanced through an artery of the subject.3. The method of further comprising reducing or eliminating escape of the infused fluid from the region.4. The method of claim 3 , further comprising applying a tourniquet proximal to the location where fluid is infused into the region from the catheter.5. The method of claim 4 , further comprising reducing flow of infused fluid through one or more collateral vessels in the region.6. The method of claim 1 , wherein the therapeutic agent is an anti-cancer agent.7. The method of claim 1 , wherein the catheter is greater than 6 french in size.8. The method of claim 7 , wherein the catheter is 7 claim 7 , 8 claim 7 , 9 claim 7 , 10 claim 7 , 11 or 12 french in size or is any size in-between 7 and 12 french.9. The method of claim 1 , wherein the fluid is infused into the region at a rate of between 150 cc/min and 600 cc/min.10. The method of claim 9 , wherein the fluid is infused into the region at 150 cc/min claim 9 , 160 cc/min claim 9 , 170 cc/min claim 9 , 180 cc/min claim 9 , 190 cc/min claim 9 , 200 cc/min claim 9 , 210 cc/min claim 9 , 220 cc/min claim 9 , 230 cc/min claim 9 , 240 cc/min claim 9 , 250 cc/min claim 9 , 260 cc/min claim 9 , 270 cc/min ...
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