08-03-2018 дата публикации
Номер: US20180064649A1
A platform drug delivery system and a method of improving the delivery of low solubility pharmaceuticals utilizing crystal engineering and Theanine dissolution resulting in enhanced bioactivity, dissolution rate, and solid state stability. 1. A cocrystal composition comprising:a quantity of a theanine enantiomer; and{'sub': 2', '3', '4', '1A', '2A', '2B', '2C', '2B, 'a quantity of a drug from a class selected from the group consisting of nucleoside analog reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, non-purine selective xanthine oxidase inhibitors, leukotriene receptor antagonists, beta-adrenergic agonists/alpha-adrenergic agonists, antihypertensive agents, loop diuretics, thiazide diuretics, atypical antipsychotic/partial dopamine agonists, non-steroidal anti-inflammatory drugs, corticosteroids, antihistamines, antineoplastic agents, antibacterial agents, antibiotics, antiviral agents, antifungal agents, antiprotozoan agents, immediate dopamine precursor agent, catechol-o-methyltransferase inhibitors, ergoline dopamine agonists, ergot derivative/dopamine D, D, D, 5-HT, 5-HT, 5-HT, 5-HT, αreceptor agonists, antiparkinsonian agents, direct-acting skeletal muscle relaxants, noncompetitive N-methyl D-aspartate receptor antagonists, zinc salts of gluconic acid, serotonin-1b and serotonin-1d receptor agonists/antimigraine agents, cytomegalovirus nucleoside analog DNA polymerase inhibitors and guanosine analogue antiviral agents.'}2. The composition of claim 1 , wherein the antihistamine is selected from the group consisting of ethanolamine and histamine Hreceptor antagonists.3. The composition of claim 1 , wherein the antineoplastic agent is selected from the group consisting of protein tyrosine kinase inhibitors claim 1 , antileukemic drugs claim 1 , topoisomerase 1 inhibitors claim 1 , and anthracycline topoisomerase inhibitors.4. The composition of claim 1 , wherein the antibiotics are selected from the group consisting of ...
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