COMPOUND HAVING SELECTIVE EP2 AGONIST ACTIVITY

A compound represented by general formula (I) wherein all symbols are as defined in the specification, a salt or N-oxide of the compound, or a solvate or prodrug of the compound or the salt or N-oxide has a selective EP2 agonist activity and is highly safe, and is therefore useful as a drug, especially as a therapeutic agent for EP2 receptor-related diseases including immune diseases, allergic diseases, neuronal death, dysmenorrhea, premature birth, miscarriage, baldness, ocular diseases, erectile dysfunction, arthritis, lung injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, bone diseases, cartilage injury and others. 2. The compound according to claim 1 , wherein E represents —O— claim 1 , —S— claim 1 , or —NH—.3. The compound according to claim 1 , wherein ring 1 represents a 5-membered monocyclic aromatic heterocyclic ring.4. The compound according to claim 1 , wherein X represents —O— or —S—.6. The compound according to claim 5 , wherein ring 1-1 represents oxazole claim 5 , thiazole claim 5 , furan or thiophene.7. The compound according to claim 1 , wherein the compound is(1) 2-{(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[(3-methyl-4-nitrophenoxy)methyl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid,(2) 2-{(2R,4aR,5S,6R,7aS)-5-[(4-chloro-3-methylphenoxy)methyl]-6-hydroxyoctahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid,(3) 2-{(2R,4aR,5S,6R,7aS)-5-[(2,3-dihydro-1H-inden-5-yloxy)methyl]-6-hydroxyoctahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid,(4) 2-{(2R,4aR,5S,6R,7aS)-5-[(3,4-dimethylphenoxy)methyl]-6-hydroxyoctahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid,(5) 2-{(2R,4aR,5S,6R,7aS)-6-hydroxy-5-[(1H-indol-5-yloxy)methyl]octahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid,(6) 2-{(2R,4aR,5S,6R,7aS)-5-[(2,3-dihydro-1H-inden-4-yloxy)methyl]-6-hydroxyoctahydrocyclopenta[b]pyran-2-yl}-1,3-thiazole-4-carboxylic acid,(7) 2-{(2R,4aR,5S,6R,7aS)-5-[(bicyclo[4. ...

Bicyclic compound and use thereof for medical purposes

Provided is a compound which has strong and sustaining intraocular pressure lowering action and, further, has no fear of side effect on eyes. Since a compound represented by the formula (I): wherein definition of each group is as described in the specification, or a salt thereof, a solvate thereof, or a prodrug thereof has strong and sustaining intraocular pressure lowering action and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.

Compound having ep2 agonist activity

Provided is an EP2 agonist having excellent safety. A compound represented by general formula (I) (wherein all symbols are as defined in the description), a salt or N-oxide of the compound, or a solvate or prodrug of the compound or the salt or N-oxide has an EP2 agonist activity and is highly safe, and is therefore useful as a medicine, particularly a therapeutic agent for diseases associated with EP2 receptors, such as immune diseases, allergic diseases, neuronal death, dysmenorrhea, premature birth, miscarriage, baldness, ocular diseases, erectile dysfunction, arthritis, lung injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, bone diseases and cartilage injury.

Compound having EP2 agonist activity

Provided is an EP2 agonist having excellent safety. A compound represented by general formula (I) (wherein all symbols are as defined in the description), a salt or N-oxide of the compound, or a solvate or prodrug of the compound or the salt or N-oxide has an EP2 agonist activity and is highly safe, and is therefore useful as a medicine, particularly a therapeutic agent for diseases associated with EP2 receptors, such as immune diseases, allergic diseases, neuronal death, dysmenorrhea, premature birth, miscarriage, baldness, ocular diseases, erectile dysfunction, arthritis, lung injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, bone diseases and cartilage injury.

Compound exhibiting selective ep2 agonist activity

กรรมวิธีการผลิตแอล-ทริโอนีนโดยกระบวนการหมัก

การประดิษฐ์ที่เสนอนี้เกี่ยวข้องกับกรรมวิธีการผลิตสารแอล-ทรีโอนีนโดยกระบวนการหมัก โดยการเพาะเลี้ยงเชื้อจุลินทรีย์ ในอาหารเหลว เชื้อจุลินทรีย์ที่ใช้ในกรรมวิธีการผลิตอยู่ในยี นัส Brevibacterium เป็นสายพันธุ์ที่กลายพันธุ์ มีคุณสมบัติที่ ไม่ผลิตเอนไซม์ dihydrodipicolinate synthase หรือผลิตใน ปริมาณน้อย หรือ อาจจะมีความสามารถต้านทานต่อ อัลฟา-amino- เบต้า-hydroxyvaleric acid และไม่ผลิตเอนไซม์ dihydrodipico linate synthase หรือ ผลิตในปริมาณน้อย จุลินทรีย์ที่กลาย พันธุ์ดังกล่าวมีความสามารถผลิต และสะสมสารทรีโอนีนในอาหาร เลี้ยงเชื้อได้มากเพิ่มขึ้น

粘着性物質の投入装置およびその投入方法

(57)【要約】 【課題】 粘着性物質であっても付着させずに円滑に投 入できる粘着性物質の投入装置およびその投入方法を提 供すること。 【解決手段】 投入される粘着性物質である粘土Ｃの少 なくとも一部をクラッシャ１４で粉砕し、このクラッシ ャ１４で粉砕された粘着性の粒状体Ｃ1 をドライヤ１９ で乾燥し、このドライヤ１９で乾燥された粒状体Ｃ2 を 粘着性物質が投入されるホッパ１２の側壁に散布手段２ ０で散布する。これにより、乾燥した投入物質Ｃと同一 成分の乾燥した粒状体Ｃ2 を散布した上に粘着性物質Ｃ を投入することで付着させることなく滑動させることが でき、わずかな量を乾燥するだけで付着を防止でき、成 分の組成変化もなく後工程での使用に何等支障もない。

Compound having selective EP2 agonist activity

A compound represented by general formula (I) wherein all symbols are as defined in the specification, a salt or N-oxide of the compound, or a solvate or prodrug of the compound or the salt or N-oxide has a selective EP2 agonist activity and is highly safe, and is therefore useful as a drug, especially as a therapeutic agent for EP2 receptor-related diseases including immune diseases, allergic diseases, neuronal death, dysmenorrhea, premature birth, miscarriage, baldness, ocular diseases, erectile dysfunction, arthritis, lung injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, bone diseases, cartilage injury and others.