18-07-2013 дата публикации
Номер: US20130184460A1
The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder: 2. The compound or the pharmaceutically acceptable salt thereof according to claim 1 , wherein{'sup': '2', 'sub': i-6', '3-6', '3-6, 'Ris a Calkyl group optionally substituted by 1 to 3 substituents selected from Group 1 of substituents, or represents a Ccycloalkyl group, a haloCcycloalkyl group, or the group of the formula [II]'}{'sub': '1-3', 'A is a single bond or a Calkylene group,'}{'sup': 5', '6', '7', '8, 'R, R, Rand Rare each a hydrogen atom,'}G is an oxygen atom,{'sup': '1', 'Aris a phenylene group, a pyridine-diyl group, a pyrimidine-diyl group, an isoxazole-diyl group, an oxadiazole-diyl group, a thiazole-diyl group, or a pyrazole-diyl group, provided that the phenylene group, the pyridine-diyl group, the pyrimidine-diyl group, the isoxazole-diyl group, the oxadiazole-diyl group, the thiazole-diyl group, or the pyrazole-diyl group may be substituted by 1 to 3 halogen atoms, and'}{'sup': '2', 'Aris a phenyl group, a naphthyl group, a pyridyl group, a pyrimidyl group, a pyrazyl group, a pyrazolyl group, a thiazolyl group, an imidazolyl group, an isoxazolyl group, a thienyl group, a triazolyl group, an indolyl group, a benzofuryl group, a quinolyl group, an isoquinolyl group, a pyridonyl group, an imidazopyridyl group, or the group of the formula [III], provided that the phenyl group, the naphthyl group, the pyridyl group, the pyrimidyl group, the pyrazyl group, the pyrazolyl group, the ...
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